IL78281A - Process for amplifying nucleic acid sequences - Google Patents

Process for amplifying nucleic acid sequences

Info

Publication number
IL78281A
IL78281A IL78281A IL7828186A IL78281A IL 78281 A IL78281 A IL 78281A IL 78281 A IL78281 A IL 78281A IL 7828186 A IL7828186 A IL 7828186A IL 78281 A IL78281 A IL 78281A
Authority
IL
Israel
Prior art keywords
nucleic acid
primer
sequence
product
treating
Prior art date
Application number
IL78281A
Other languages
English (en)
Other versions
IL78281A0 (en
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27109640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL78281(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of IL78281A0 publication Critical patent/IL78281A0/xx
Publication of IL78281A publication Critical patent/IL78281A/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00495Means for heating or cooling the reaction vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Lubricants (AREA)
IL78281A 1985-03-28 1986-03-27 Process for amplifying nucleic acid sequences IL78281A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71697585A 1985-03-28 1985-03-28
US06/791,308 US4683202A (en) 1985-03-28 1985-10-25 Process for amplifying nucleic acid sequences

Publications (2)

Publication Number Publication Date
IL78281A0 IL78281A0 (en) 1986-07-31
IL78281A true IL78281A (en) 1991-06-10

Family

ID=27109640

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78281A IL78281A (en) 1985-03-28 1986-03-27 Process for amplifying nucleic acid sequences

Country Status (15)

Country Link
US (1) US4683202A (fr)
EP (5) EP0201184B2 (fr)
JP (1) JP2622327B2 (fr)
KR (2) KR900008742B1 (fr)
AT (2) ATE83505T1 (fr)
AU (1) AU586233B2 (fr)
CA (1) CA1237685A (fr)
DE (5) DE3687287T3 (fr)
DK (1) DK171160B1 (fr)
ES (1) ES8706822A1 (fr)
HK (2) HK84094A (fr)
IE (3) IE62098B1 (fr)
IL (1) IL78281A (fr)
NZ (1) NZ215605A (fr)
SG (1) SG111193G (fr)

Families Citing this family (7247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
CA1278755C (fr) * 1985-03-15 1991-01-08 William J. Knowles Marquage d'oligonucleotides
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US5386022A (en) * 1985-03-28 1995-01-31 Hoffman-La Roche Inc. Primes and probes for the amplification and detection of aids associated nucleic acids
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US5656493A (en) * 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US6197563B1 (en) 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US5333675C1 (en) * 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5635389A (en) * 1985-05-02 1997-06-03 Institut Pasteur Antibodies which recognize and bind human villin
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US6872817B1 (en) 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US7115709B1 (en) 1986-01-16 2006-10-03 The Regents Of The University Of California Methods of staining target chromosomal DNA employing high complexity nucleic acid probes
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA1339653C (fr) * 1986-02-25 1998-02-03 Larry J. Johnson Appareil servant a l'amplification automatisee de sequences nucleotidiques et d'essais au moyen de cycle de chauffage et de refroidissement
US6194561B1 (en) * 1986-03-13 2001-02-27 Roche Molecular Systems, Inc. Characterization and detection of sequences associated with autoimmune diseases
US5310893A (en) * 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US5604099A (en) * 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
CA1284931C (fr) * 1986-03-13 1991-06-18 Henry A. Erlich Procede de detection de variations specifiques de nucleotides et de polymorphismes genetiques dans les acides nucleiques
GB8606719D0 (en) 1986-03-19 1986-04-23 Lister Preventive Med Genetic probes
US5218099A (en) * 1986-04-01 1993-06-08 The United States Of America As Represented By The Department Of Health And Human Services Post-transfusion, non-A, non-B hepatitis virus polynucleotides
US5356774A (en) * 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US5215914A (en) * 1986-06-18 1993-06-01 American Registry Of Pathology Adherent and invasive mycoplasma
US7223842B1 (en) 1986-08-11 2007-05-29 Massachusetts Eye And Ear Infirmary Detection of proteins whose absence is associated with a neoplasm
US5853988A (en) * 1986-08-11 1998-12-29 Massachusetts Eye And Ear Infirmary Diagnosis of retinoblastoma
US7384735B1 (en) 1986-08-11 2008-06-10 Massachusetts Eye And Ear Infirmary Retinoblastoma nucleic acids
US5795762A (en) * 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
AU632857C (en) * 1986-08-22 2003-10-09 F. Hoffmann-La Roche Ag Purified thermostable enzyme
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5310652A (en) * 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5407800A (en) * 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
US5352600A (en) * 1986-08-22 1994-10-04 Hoffmann-La Roche Inc. Purified thermostable enzyme
US6127155A (en) * 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5618711A (en) * 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5466591A (en) * 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5306493A (en) * 1986-10-03 1994-04-26 Miles Inc. FeLV-infected feline cell line
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5079351A (en) * 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5268268A (en) * 1986-11-26 1993-12-07 Hoffmann-La Roche Inc. Detection of HTLVI and HTLVII viruses by hybridization
AU619170B2 (en) * 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
US5145776A (en) * 1987-01-14 1992-09-08 President & Fellows Of Harvard College Method of using T7 DNA polymerase to mutagenize and fill-in DNA
US4921794A (en) * 1987-01-14 1990-05-01 President And Fellows Of Harvard College T7 DNA polymerase
US4994372A (en) * 1987-01-14 1991-02-19 President And Fellows Of Harvard College DNA sequencing
US5266466A (en) * 1987-01-14 1993-11-30 President And Fellows Of Harvard College Method of using T7 DNA polymerase to label the 3' end of a DNA molecule
US4942130A (en) * 1987-01-14 1990-07-17 President & Fellows Of Harvard College T7 DNA polymerase
US4946786A (en) * 1987-01-14 1990-08-07 President And Fellows Of Harvard College T7 DNA polymerase
KR880010128A (ko) * 1987-02-12 1988-10-07 나카사와 다로 단쇄 dna의 조제방법
ATE121794T1 (de) 1987-02-26 1995-05-15 Univ Sydney Verfahren zum nachweis des karzinogenen menschlichen papillomavirus.
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) * 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
EP0290144A1 (fr) * 1987-05-05 1988-11-09 City of Hope Méthode de détection de résistance naissante à des agents thérapeutiques chez des malades cancéreux
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
DE3721400A1 (de) * 1987-06-29 1989-01-12 Viktor Dr Dr Med Balazs Verfahren zur untersuchung einer azellularen biologischen fluessigkeit auf zellulare onkogen-dna bzw. deren fragmente
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US5273879A (en) * 1987-07-23 1993-12-28 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US6090591A (en) * 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
IE72468B1 (en) * 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
DE3726934A1 (de) * 1987-08-13 1989-02-23 Merck Patent Gmbh Verfahren zum nachweis von nukleinsaeure-sequenzen
US5212080A (en) * 1987-10-05 1993-05-18 Washington University Method of DNA sequencing using DNA transposon Tn5seql
US5137829A (en) * 1987-10-05 1992-08-11 Washington University DNA transposon TN5SEQ1
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
EP0358737A4 (en) * 1988-01-28 1992-04-08 Mayo Foundation For Medical Education And Research Genomic amplification with direct sequencing
US6027913A (en) * 1988-01-28 2000-02-22 Sommer; Steven S. Nucleic acid amplification with direct sequencing
JP2650159B2 (ja) * 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
CA1340807C (fr) * 1988-02-24 1999-11-02 Lawrence T. Malek Procede d'amplification d'une sequence d'acide nucleique
IE61148B1 (en) * 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
US5024934A (en) * 1988-03-14 1991-06-18 The Board Of Regents, The University Of Texas System Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification
CA1338526C (fr) * 1988-03-18 1996-08-20 Charles Thomas Caskey Detection de mutations par amorcage competitif d'oligonucletides
WO1989009284A1 (fr) * 1988-03-24 1989-10-05 University Of Iowa Research Foundation Systemes d'hybridation catalytiques servant a detecter des sequences d'acide nucleique, fondes sur l'activite de ces sequences en tant que cofacteurs dans des reactions catalytiques ou une sonde d'acide nucleique complementaire marquee est soumise a une operation de clivage
US5614620A (en) * 1988-03-30 1997-03-25 Arch Development Corporation DNA binding proteins including androgen receptor
US4999290A (en) * 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
CA1341584C (fr) * 1988-04-06 2008-11-18 Bruce Wallace Methode d'amplification at de detection de sequences d'acides nucleiques
JPH03504199A (ja) * 1988-05-10 1991-09-19 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー 迅速な核酸検出法
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
AU3748489A (en) * 1988-06-17 1990-01-12 Genelabs Incorporated Enterically transmitted non-a/non-b hepatitis viral agent
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US4962020A (en) * 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5498523A (en) * 1988-07-12 1996-03-12 President And Fellows Of Harvard College DNA sequencing with pyrophosphatase
AU3974989A (en) * 1988-07-26 1990-02-19 Genelabs Incorporated Sequence-specific amplification techniques
EP0426756A4 (en) * 1988-07-26 1991-11-21 Genelabs Incorporated Rna and dna amplification techniques
WO1990001563A1 (fr) * 1988-08-01 1990-02-22 Cimino George D Identification de sequences d'acide nucleique specifiques d'alleles par hybridation au moyen de sondes d'oligonucleotides reticulables
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5523205A (en) * 1988-08-02 1996-06-04 Institut Pasteur DNA probes specific for hemolytic listeria
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5057410A (en) * 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5324664A (en) * 1988-08-08 1994-06-28 The Upjohn Company Herpes virus thymidien kinase-encoding DNA
JP3439472B2 (ja) * 1988-08-08 2003-08-25 ファルマシア・アンド・アップジョン・カンパニー ヘルペスウイルスチミジンキナーゼをコード付けするdnaの単離方法
US5760203A (en) * 1988-08-10 1998-06-02 Chiron Corporation Gap gene sequences
US5763573A (en) * 1988-08-10 1998-06-09 Chiron Corporation GTPase activating protein fragments
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5858652A (en) * 1988-08-30 1999-01-12 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
FR2636075B1 (fr) * 1988-09-07 1991-11-15 Biotechnologie Ste Europ Procede de detection des bacteries, levures, parasites et autres eucaryotes, notamment dans les produits alimentaires
CA1339991C (fr) * 1988-09-08 1998-08-11 The Trustees Of Columbia University Systeme d'amplification/detection a base d'arn susceptible de replication
US5447839A (en) * 1988-09-09 1995-09-05 Hoffmann-La Roche Inc. Detection of human papillomavirus by the polymerase chain reaction
US5132215A (en) * 1988-09-15 1992-07-21 Eastman Kodak Company Method of making double-stranded dna sequences
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5091310A (en) * 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5142033A (en) * 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5066584A (en) * 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
WO1990003445A1 (fr) * 1988-09-30 1990-04-05 The Salk Institute For Biological Studies Systemes d'amplification/detection d'acides nucleiques cibles
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5389512A (en) * 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US6641999B1 (en) 1988-10-19 2003-11-04 The Dow Chemical Company Probing method for identifying antibodies specific for selected antigens
US5296351A (en) * 1988-10-20 1994-03-22 Alexander A. Morley Method for diagnosis of monoclonality in leukaemia and lymphoma
US5077192A (en) * 1988-10-25 1991-12-31 The General Hospital Corporation Method of detecting antigenic, nucleic acid-containing macromolecular entities
FR2638464B1 (fr) * 1988-10-28 1992-01-03 Pasteur Institut Fragments d'acide nucleique specifiques du gene de la villine humaine, leur utilisation aux fins de diagnostic
ATE102631T1 (de) * 1988-11-11 1994-03-15 Medical Res Council Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
US5880260A (en) 1988-11-18 1999-03-09 Oregon Health Sciences University Dopamine receptors and genes
CA2001110A1 (fr) * 1988-11-18 1990-05-18 Zvi G. Loewy Composes et procede pour amplifier et detecter les sequences d'acide nucleique
US5759820A (en) * 1988-11-21 1998-06-02 Dynal As Process for producing cDNA
US5489507A (en) * 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
EP0446305B1 (fr) * 1988-12-05 1996-05-08 The Salk Institute For Biological Studies Systemes d'amplification/detection d'acides nucleiques
US5631129A (en) * 1988-12-05 1997-05-20 The Salk Institute For Biological Studies Target nucleic acid amplification/detection systems and methods for the use thereof
HU216105B (hu) * 1988-12-16 1999-04-28 Akzo Nobel N.V. Amplifikációs eljárás önfenntartó szekvenciareplikációs rendszerrel
FR2641792A1 (fr) * 1988-12-28 1990-07-20 Pasteur Institut Sequences de nucleotides codant pour la calmoduline chez l'homme et leurs applications biologiques
US4983511A (en) * 1989-01-09 1991-01-08 Olin Corporation Method and kit for detecting live microorganisms in chlorine- or bromine-treated water
ES2093633T3 (es) * 1989-01-19 1997-01-01 Behringwerke Ag Amplificacion de acidos nucleicos utilizando un unico cebador.
WO1990008821A1 (fr) * 1989-01-31 1990-08-09 University Of Miami Micro-dissection et amplification de l'adn chromosomique
US5514550A (en) * 1989-02-03 1996-05-07 Johnson & Johnson Clinical Diagnostics, Inc. Nucleic acid test article and its use to detect a predetermined nucleic acid
GB8902689D0 (en) * 1989-02-07 1989-03-30 Ici Plc Assay method
CA2046919A1 (fr) * 1989-02-14 1990-08-15 Mark P. Pasek Paires d'amorces oligonucleotidiques pour l'amplification d'un gene de sequence inconnue
US5380645A (en) * 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5001050A (en) * 1989-03-24 1991-03-19 Consejo Superior Investigaciones Cientificas PHφ29 DNA polymerase
CA2012983A1 (fr) * 1989-03-27 1990-09-27 Sydney Brenner Procede pour la detection de l'acide nucleique par amplification binaire
US5075212A (en) * 1989-03-27 1991-12-24 University Of Patents, Inc. Methods of detecting picornaviruses in biological fluids and tissues
CA2012984A1 (fr) * 1989-03-27 1990-09-27 Frank W. Hobbs Jr. Procede pour la detection rapide de l'acide nucleique par incorporation d'un groupe marqueur dans l'acide nucleique detecte par amplification de la cible, et ensuite par capture par affinite
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5284760A (en) * 1989-04-03 1994-02-08 Feinstone Stephen M Techniques for producing site-directed mutagenesis of cloned DNA
AU638246B2 (en) * 1989-04-12 1993-06-24 President And Fellows Of Harvard College Improved primer extension reactions
FR2645877B1 (fr) * 1989-04-12 1991-07-05 Pasteur Institut Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes
CA2013317A1 (fr) * 1989-04-17 1990-10-17 Fred T. Oakes Trousse de diagnostic, amorce et son utilisation pour la replication ou la detection d'acides nucleiques
US5334499A (en) * 1989-04-17 1994-08-02 Eastman Kodak Company Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5582979A (en) * 1989-04-21 1996-12-10 Marshfield Clinic Length polymorphisms in (dC-dA)n.(dG-dT)n sequences and method of using the same
US5075217A (en) * 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5106727A (en) * 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
CA2016518A1 (fr) * 1989-05-11 1990-11-11 Peter Baram Systeme de diagnostic a base d'acide nucleique pour la detection de pneumocystis carinii dans les produits sanguins
US6291158B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
GR1002158B (en) * 1989-05-16 1996-02-23 Stratagene Inc Method for tapping the immunological repertoire
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
GR1002149B (en) * 1989-05-16 1996-02-20 Scripps Clinic Res Method for producing polymers having a preselected activity
US6291160B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
JP2656996B2 (ja) * 1989-05-18 1997-09-24 カイロン コーポレイション Nanbvの診断用薬
JP3082942B2 (ja) * 1989-05-22 2000-09-04 エフ・ホフマンーラ ロシュ アーゲー 核酸による物質の標識及び追跡方法
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5035996A (en) * 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5279938A (en) * 1989-06-05 1994-01-18 The United States Of America As Represented By The Department Of Health And Human Services Sensitive diagnostic test for lyme disease
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
JPH04506599A (ja) * 1989-06-12 1992-11-19 セーイーエス ビオ アンテルナショナル 特定の核酸配列を検出する方法及びその応用
US5055393A (en) * 1989-06-13 1991-10-08 Salk Institute Biotechnology/Industrial Associates, Inc. Prenatal sex determination of bovine cells using male-specific oligonucleotides
US5045449A (en) * 1989-06-14 1991-09-03 Thomas Jefferson University Methods of detecting a genetic predisposition for vascular aneurysms
EP0406937A3 (en) * 1989-06-30 1992-01-22 Eastman Kodak Company In vitro gene synthesis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
CA2020958C (fr) * 1989-07-11 2005-01-11 Daniel L. Kacian Methodes d'amplification de sequences d'acide nucleique
EP0731175A3 (fr) * 1989-07-11 2004-05-26 Gen-Probe Incorporated Sondes oligonucléotidiques pour d'acide nucléique de VIH
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5045450A (en) * 1989-07-13 1991-09-03 Massachusetts Institute Of Technology Determination of a mutational spectrum
DE69032778T2 (de) * 1989-07-18 1999-07-29 Shimadzu Corp Verfahren zur Untersuchung von durch Mikroorganismen verursachten Lebensmittelvergiftungen und Reagens dafür
US5219739A (en) * 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
US5124041A (en) * 1989-07-28 1992-06-23 Applied Biosystems, Inc. Biomolecule sample immobilization
US6803499B1 (en) 1989-08-09 2004-10-12 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5550318A (en) * 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5023171A (en) * 1989-08-10 1991-06-11 Mayo Foundation For Medical Education And Research Method for gene splicing by overlap extension using the polymerase chain reaction
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US20040197775A1 (en) * 1989-08-25 2004-10-07 Genetype A.G. Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5213961A (en) * 1989-08-31 1993-05-25 Brigham And Women's Hospital Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
DE69026716T2 (de) * 1989-09-06 1996-11-14 Pasteur Institut Nukleinsäurefragmente von einem genom eines geeigneten mykobakteriums, ihre verwendung zur diagnose von mykobakterieninfektionen sowie diese fragmente enthaltende plasmide
GB8920097D0 (en) * 1989-09-06 1989-10-18 Ici Plc Amplification processes
US5438126A (en) * 1989-09-11 1995-08-01 Arch Development Corporation Human thyroid hormone receptor DNA
US5196305A (en) * 1989-09-12 1993-03-23 Eastman Kodak Company Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end
CA2065287C (fr) 1989-09-15 1999-12-21 Tatsuo Miyamura Isolats hvc nouveaux
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5232829A (en) * 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
WO1991005058A1 (fr) * 1989-10-05 1991-04-18 Glenn Kawasaki Synthese et isolation sans cellule de nouveaux genes et de nouveaux polypeptides
EP0448688A4 (en) * 1989-10-16 1993-07-28 Amgen Inc. N-acetylmuramidase m1
US5599696A (en) * 1989-10-17 1997-02-04 California Institute Of Technology Method of preparing nucleic acids having an undefined nucleotide sequence amplification
US5503721A (en) 1991-07-18 1996-04-02 Hri Research, Inc. Method for photoactivation
US5532145A (en) * 1989-10-26 1996-07-02 Steritech, Inc. Methods for treatment of enzyme preparations
US5532146A (en) * 1989-10-26 1996-07-02 Hri Research, Inc. Method for rendering ligase-based amplification products unamplifiable
US5139940A (en) * 1989-10-26 1992-08-18 Isaacs Stephen T Activation compounds and methods of synthesis of activation compounds
US6007984A (en) * 1989-11-01 1999-12-28 Zeneca Limited Detection of DNA/RNA by fluorescence polarization
US5863717A (en) * 1989-11-03 1999-01-26 Abbott Laboratories Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences
WO1991007506A1 (fr) * 1989-11-08 1991-05-30 The United States Of America, Represented By The Secretary, United States Department Of Commerce Procede de synthese de molecules d'adn bicatenaire
JP3310281B2 (ja) * 1989-11-08 2002-08-05 ベイラー カレッジ オブ メディシン ノーワーク及び関連のウィルスを検出し同定するための方法と試薬
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
DE4001154A1 (de) * 1990-01-17 1991-07-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von modifizierten nukleinsaeuren
CA2033718A1 (fr) * 1990-01-19 1991-07-20 Ronald M. Atlas Procede de detection d'agents pathogenes microbiens dans l'eau et indicateurs de contamination par des matieres fecales humaines dans des echantillons d'eau et trousses de detection connexes
US5484956A (en) * 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6025545A (en) * 1990-01-22 2000-02-15 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US6329574B1 (en) * 1990-01-22 2001-12-11 Dekalb Genetics Corporation High lysine fertile transgenic corn plants
US6777589B1 (en) 1990-01-22 2004-08-17 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
CA2074355C (fr) * 1990-01-22 2008-10-28 Ronald C. Lundquist Plants de mais transgeniques fertiles
AU7224591A (en) * 1990-01-24 1991-08-21 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A rapid and sensitive test for detecting hepatitis a virus
KR950013953B1 (ko) * 1990-01-26 1995-11-18 애보트 래보라토리즈 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법
US6013431A (en) * 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
ATE188509T1 (de) * 1990-02-16 2000-01-15 Hoffmann La Roche Verbesserungen in der spezifität und zweckmässigkeit der polymerase-kettenreaktion
US5049490A (en) * 1990-02-20 1991-09-17 Eastman Kodak Co. Quantitative determination of a DNA polymerase and a test kit useful in same
JPH0632639B2 (ja) 1990-02-26 1994-05-02 アメリカ合衆国 Dna配列を即時に蛍光検出する方法
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
EP0519016A1 (fr) * 1990-03-07 1992-12-23 F.Hoffmann-La Roche & Co. Aktiengesellschaft Methode de diagnostic de la maladie de lyme
US5126239A (en) * 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
US20030219446A1 (en) * 1990-03-26 2003-11-27 Bristol-Myers Squibb Company Ligand for CD28 receptor on B cells and methods
US7070776B1 (en) 1990-03-26 2006-07-04 Bristol-Myers Squibb Company Methods for blocking binding of CD28 receptor to B7
US5580756A (en) * 1990-03-26 1996-12-03 Bristol-Myers Squibb Co. B7Ig fusion protein
WO1991015599A1 (fr) * 1990-04-05 1991-10-17 Amrad Corporation Limited Procede de detection de l'adn
WO1991015516A2 (fr) * 1990-04-06 1991-10-17 Genelabs Incorporated Epitopes du virus de l'hepatite c
US5198337A (en) * 1990-04-13 1993-03-30 State Of Oregon Assay for gene deletion of GST-1 in human samples based on the polymerase chain reaction
US5352778A (en) * 1990-04-26 1994-10-04 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5500363A (en) * 1990-04-26 1996-03-19 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5756334A (en) * 1990-04-26 1998-05-26 New England Biolabs, Inc. Thermostable DNA polymerase from 9°N-7 and methods for producing the same
US5322785A (en) * 1990-04-26 1994-06-21 New England Biolabs, Inc. Purified thermostable DNA polymerase obtainable from thermococcus litoralis
US5407813A (en) * 1990-05-01 1995-04-18 Gold Biotechnology Preparation of nucleic acid deletion fragments
DK0528882T3 (da) 1990-05-03 2008-01-14 Cornell Res Foundation Inc DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5387505A (en) * 1990-05-04 1995-02-07 Eastman Kodak Company Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
KR100245284B1 (ko) * 1990-05-07 2000-03-02 이노우에 노리유끼 이중 d-루프 형성의 진단학적 응용
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5310649A (en) * 1990-05-22 1994-05-10 Texas A & M University System Method for detecting species and biovars of Brucella
US5348857A (en) * 1990-05-22 1994-09-20 Texas A & M University Probes and method for identifying species and biovars of brucella
US7294712B2 (en) * 1990-06-04 2007-11-13 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) * 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US5296349A (en) * 1990-06-14 1994-03-22 Emory University Molecular genetic test for myoclonic epilepsy
US5844108A (en) * 1990-06-22 1998-12-01 Roche Molecular Systems, Inc. Primers targeted to NAT2 gene for detection of poor metabolizers of drugs
ES2103756T3 (es) * 1990-06-22 1997-10-01 Hoffmann La Roche Deteccion de metabolizadores ineficaces de farmacos.
US5187084A (en) * 1990-06-22 1993-02-16 The Dow Chemical Company Automatic air temperature cycler and method of use in polymerose chain reaction
US6503707B1 (en) 1990-06-27 2003-01-07 The Blood Center Research Foundation, Inc. Method for genetic typing
US5545526A (en) * 1990-06-27 1996-08-13 Blood Center Research Foundation, Inc., The Method for HLA Typing
US5702885A (en) * 1990-06-27 1997-12-30 The Blood Center Research Foundation, Inc. Method for HLA typing
FR2663949A1 (fr) 1990-06-29 1992-01-03 Genset Sa Perfectionnements a un procede d'amplification enzymatique in vitro.
DE4021458C1 (fr) * 1990-07-05 1991-08-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
US5134063A (en) * 1990-07-06 1992-07-28 Biolog, Inc. Methods for detection, identification and specification of listerias
US5556747A (en) * 1990-07-09 1996-09-17 E. R. Squibb & Sons, Inc. Method for site-directed mutagenesis
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis
ES2128323T3 (es) * 1990-07-24 1999-05-16 Hoffmann La Roche Reduccion de la amplificacion no-especifica durante la amplificacion in vitro del acido nucleico empleando bases de acido nucleico modificadas.
JP3269641B2 (ja) * 1990-07-26 2002-03-25 寳酒造株式会社 カンジダ属酵母遺伝子
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6395966B1 (en) 1990-08-09 2002-05-28 Dekalb Genetics Corp. Fertile transgenic maize plants containing a gene encoding the pat protein
JP2560160B2 (ja) * 1990-08-20 1996-12-04 社団法人北里研究所 新規なdna塩基配列およびその用途
US6074818A (en) * 1990-08-24 2000-06-13 The University Of Tennessee Research Corporation Fingerprinting of nucleic acids, products and methods
DE69128545D1 (de) * 1990-08-24 1998-02-05 Univ Tennessee Res Corp Technik des genetischen fingerabdrucks mit dns-vervielfältigung
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
US5824477A (en) * 1990-09-12 1998-10-20 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5527670A (en) * 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
WO1992006191A1 (fr) * 1990-09-28 1992-04-16 Protein Engineering Corporation Agents d'elimination de la plaque dentaire a base de proteines
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
US5932414A (en) * 1990-09-28 1999-08-03 University Of Texas Systems Board Of Regents Methods and compositions for the monitoring and quantitation of minimal residual disease in hematopoietic tumors
US5620847A (en) * 1990-10-05 1997-04-15 Hoffman-La Roche Inc. Methods and reagents for detection of bacteria in cerebrospinal fluid
ES2070415T3 (es) 1990-10-05 1995-06-01 Akzo Nobel Nv Peptidos inmunoquimicamente reactivos con anticuerpos dirigidos contra el virus de la hepatitis no-a, no-b.
US5635348A (en) * 1990-10-05 1997-06-03 Hoffmann-La Roche Inc. Method and probes for identifying bacteria found in blood
US5965364A (en) 1990-10-09 1999-10-12 Benner; Steven Albert Method for selecting functional deoxyribonucleotide derivatives
WO1992007095A1 (fr) 1990-10-15 1992-04-30 Stratagene Procede de reaction en chaine de polymerase arbitrairement amorcee destine a produire une empreinte genetique de genomes
JPH04152899A (ja) * 1990-10-17 1992-05-26 Shionogi & Co Ltd 2段階pcr法によるhiv―1ゲノムの検出法およびオリゴヌクレオチド
DK0555357T3 (da) * 1990-10-22 2002-10-28 Genentech Inc Fremgangsmåder til modificering og påvisning af effekterne på interaktionen af modificerede polypeptider og målsubstrater
US5846710A (en) * 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
AU8953991A (en) * 1990-11-06 1992-05-26 Lubrizol Corporation, The Compositions and methods for analyzing genomic variation
JPH06502766A (ja) * 1990-11-14 1994-03-31 アクゾ・ノベル・ナムローゼ・フェンノートシャップ ポリスチレン支持体ベース−サンドイッチハイブリダイゼーションアッセイ法を用いる核酸の非同位体検出およびそれに用いる組成物
US5284940A (en) * 1990-11-14 1994-02-08 Hri Research, Inc. Preparation for nucleic acid samples
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5620852A (en) * 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート,リミテッド ライアビリティ カンパニー 宿主細胞でのpaceの発現およびその使用法
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
EP0488243A1 (fr) * 1990-11-30 1992-06-03 Sanwa Kagaku Kenkyusho Co., Ltd. Procédé d'extraction du génome du virus d'un échantillon derivé d'un corps vivant infecté par le virus et procédé de détection du génome
DE69132905T2 (de) 1990-12-06 2002-08-01 Affymetrix Inc N D Ges D Staat Detektion von Nukleinsäuresequenzen
US5569601A (en) 1990-12-07 1996-10-29 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Human dopamine receptor and its uses
IL100460A (en) * 1990-12-20 1997-06-10 Ixsys Method for optimization of binding proteins and nucleic acids encoding a binding protein produced thereby
US5162209A (en) * 1991-01-18 1992-11-10 Beth Israel Hospital Association Synthesis of full-length, double-stranded dna from a single-stranded linear dna template
US5714326A (en) * 1991-01-24 1998-02-03 Dawson; Elliott P. Method for the multiplexed preparation of nucleic acid molecular weight markers and resultant products
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
EP0570497B1 (fr) * 1991-02-05 1996-05-08 Lifecodes Corporation Identification genetique moleculaire utilisant des sondes qui reconnaissent des locus polymorphes
WO1992013950A2 (fr) * 1991-02-12 1992-08-20 Roussel-Uclaf SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES β DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
US5491068A (en) * 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
DE69233769D1 (de) * 1991-03-01 2009-09-24 Dyax Corp Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
US5888819A (en) * 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
EP0577708A4 (en) * 1991-03-06 1998-02-04 Univ Minnesota Dna sequence-based hla typing method
US5578443A (en) * 1991-03-06 1996-11-26 Regents Of The University Of Minnesota DNA sequence-based HLA typing method
CA2062377A1 (fr) 1991-03-21 1992-09-22 Mariano Barbacid Methode de detection de substances neuroactives
US5767063A (en) * 1991-03-29 1998-06-16 Genentech, Inc. Human IL-8 receptor and antibodies thereto
US5436144A (en) * 1991-04-08 1995-07-25 Health Research, Inc. Process for performing PCR in mammalian cells
WO1992018521A1 (fr) * 1991-04-10 1992-10-29 Life Technologies, Inc. Procede d'amplification et de modification d'une sequence d'arn
AU656965B2 (en) * 1991-04-11 1995-02-23 Dade Behring Inc. Detection of DNA/RNA by fluorescence polarization
US5283175A (en) * 1991-04-15 1994-02-01 The Research Foundation Of State University Of New York Genus-specific oligomers of Borrelia and methods of using same
AU1970892A (en) * 1991-04-18 1992-11-17 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Identification of a new ehrlichia species from a patient suffering from ehrlichiosis
US5550024A (en) * 1991-04-19 1996-08-27 Biotechnology Research & Development Corporation Genetic markers for pig litter size
CA2065719A1 (fr) 1991-04-30 1992-10-31 John B. Findlay Amplification d'acides nucleiques et methodes de detection faisant appel au cycle rapide de la reaction en chaine a la polymerase
US5525462A (en) * 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
US5571690A (en) * 1991-05-08 1996-11-05 The University Of Virginia Patents Foundation Method for the cell-free synthesis of proteins
US5610276A (en) * 1991-05-17 1997-03-11 Chiron Corporation Polypeptides and antibodies derived from GAP associated protein, p62
WO1992020795A1 (fr) * 1991-05-17 1992-11-26 Cetus Oncology Corporation INHIBITEUR DE L'ACTIVATEUR DE TRANSCRIPTION NF-λB ET UTILISATIONS DUDIT INHIBITEUR
US5753488A (en) * 1991-05-23 1998-05-19 Martin; William John Isolated stealth viruses and related vaccines
US5703221A (en) * 1991-05-23 1997-12-30 Martin; William John Stealth virus nucleic acids and related methods
US5756281A (en) * 1991-05-23 1998-05-26 Martin; William John Stealth virus detection in the chronic fatigue syndrome
US5468610A (en) * 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5378602A (en) * 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5861504A (en) * 1991-05-29 1999-01-19 The United States Of America As Represented By The Department Of Health And Human Services Eleven highly informative microsatelite repeat polymorphic DNA markers
US5658728A (en) * 1991-06-19 1997-08-19 Gosney, Jr.; William Milton Templates for nucleic acid molecules
ES2091976T3 (es) * 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
US6887471B1 (en) * 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US6090914A (en) * 1991-06-27 2000-07-18 Bristol-Myers Squibb Company CTLA4/CD28Ig hybrid fusion proteins and uses thereof
ATE170562T1 (de) * 1991-06-27 1998-09-15 Bristol Myers Squibb Co Ctl4a rezeptor, ihn enthaltenden fusionsproteine und deren verwendungen
US5851795A (en) * 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5770197A (en) * 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
US5844095A (en) * 1991-06-27 1998-12-01 Bristol-Myers Squibb Company CTLA4 Ig fusion proteins
US5569582A (en) * 1991-07-15 1996-10-29 Institute Of Molecular Biology & Technology Rapid amplification and detection of nucleic acids
US5260199A (en) * 1991-07-30 1993-11-09 Wisconsin Alumni Research Foundation Method of producing 1,25-dihydroxyvitamin D3 receptor protein
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
US5478724A (en) * 1991-08-16 1995-12-26 The Rockefeller University Lentivirus-specific nucleotide probes and methods of use
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
US6872816B1 (en) * 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
AU2663292A (en) * 1991-09-10 1993-04-05 Jack D. Love Dna/rna target and signal amplification
EP0534640B1 (fr) * 1991-09-23 1996-10-02 Pfizer Inc. Procédé pour détecter ARNm et ADN spécifiques dans les cellules
WO1993007161A1 (fr) * 1991-10-04 1993-04-15 Cornell Research Foundation, Inc. Clonage moleculaire et transformation de la resistance aux cyclodienes
US5612199A (en) * 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
ES2112302T3 (es) 1991-10-11 1998-04-01 Behringwerke Ag Metodo para producir un polinucleotido para uso en amplificacion con un unico cebador y oligonucleotidos que contienen fosforotioato como cebadores para la amplificacion de acidos nucleicos.
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6265157B1 (en) 1991-12-03 2001-07-24 Allegheny University Of The Health Sciences Compositions and methods for detecting altered COL1A1 gene sequences
IL103935A0 (en) * 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
US5939524A (en) * 1991-12-09 1999-08-17 The Scripps Research Institute Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
US5869282A (en) 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5256555A (en) 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
WO1993013207A2 (fr) * 1991-12-31 1993-07-08 Zymogenetics, Inc. Nouvelles transglutaminases humaines
US5656467A (en) * 1992-01-09 1997-08-12 The Trustees Of The University Of Pennsylvania Methods and materials for producing gene libraries
USH1985H1 (en) 1992-01-09 2001-08-07 The United States Of America As Represented By The Secretary Of The Navy Method for detecting biological toxins
WO1993014217A1 (fr) * 1992-01-10 1993-07-22 Life Technologies, Inc. Utilisation de nucleotides predetermines possedant des caracteristiques modifies d'appariement de bases dans l'amplification de molecules d'acide nucleique
GB9201481D0 (en) * 1992-01-23 1992-03-11 Scient Generics Ltd Treatment of nucleic acid material
IL104419A0 (en) * 1992-01-24 1993-05-13 Fmc Corp Insecticidally effective peptides
US5372929A (en) * 1992-01-27 1994-12-13 Cimino; George D. Methods for measuring the inactivation of pathogens
US6200747B1 (en) 1992-01-28 2001-03-13 North Shore University Hospital Research Corp. Method and kits for detection of fragile X specific, GC-rich DNA sequences
DE69333073T2 (de) * 1992-02-12 2004-04-15 Chromagen, Inc., San Diego Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
US5859219A (en) * 1992-02-26 1999-01-12 Vanderbilt University Purified vacuolating toxin from Helicobacter pylori and methods to use same
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5407814A (en) * 1992-03-20 1995-04-18 The Secretary Of State For The Minister Of Agriculture, Fisheries & Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Genetic fingerprinting of yeasts
US5420009A (en) * 1992-03-23 1995-05-30 The United States Of America As Represented By The Secretary Of Agriculture Detection of Xanthomonas campestris pv. citri by hybridization and polymerase chain reaction assays
US5308751A (en) * 1992-03-23 1994-05-03 General Atomics Method for sequencing double-stranded DNA
DE69207580T2 (de) * 1992-03-23 1996-08-08 Hoffmann La Roche Verfahren zum DNS-Nachweis
JPH05260980A (ja) * 1992-03-23 1993-10-12 Tokyo Met Gov Shinkei Kagaku Sogo Kenkyusho ヒト・アリルアミンn−アセチル転移酵素遺伝子
WO1993020234A1 (fr) * 1992-03-31 1993-10-14 E.I. Du Pont De Nemours And Company Dosage rapide, a haute capacite, fonde sur l'acide nucleique
US5470705A (en) * 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
EP0636186B1 (fr) * 1992-04-03 1998-11-25 The Perkin-Elmer Corporation Procede et composition de sondage
US5280112A (en) * 1992-04-10 1994-01-18 State Of Oregon, Oregon Health Sciences University DNA sequence encoding bovine and human adrenocorticotropic hormone receptors
US6100048A (en) * 1992-04-10 2000-08-08 Oregon Health Sciences University Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
US5532347A (en) * 1992-04-10 1996-07-02 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization DNA encoding α melanocyte stimulating hormone receptor
US6110742A (en) * 1992-04-15 2000-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Synthetic antisense oligodeoxynucleotides targeted to AChE
FR2690691B1 (fr) * 1992-04-29 1999-02-12 Bio Merieux Procede d'amplification d'arn necessitant une seule etape de manipulation.
USRE39031E1 (en) * 1992-04-29 2006-03-21 Biomerieux RNA amplification method requiring only one manipulation step
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
WO1993022461A1 (fr) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Procede, composition et kit pour l'amplification de sequences d'acides nucleiques
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) * 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
CA2137563C (fr) * 1992-06-08 2005-06-28 Thomas B. Ryder Obtention d'acides nucleiques a partir de cellules mononucleees
ATE195553T1 (de) 1992-06-09 2000-09-15 Chiron Corp Kristallisierung von m-csf
ES2044784B1 (es) * 1992-06-12 1994-09-01 Inia Procedimiento para la deteccion e identificacion de patogenos virales y subvirales.
WO1994000598A1 (fr) * 1992-06-19 1994-01-06 Northwestern University Procede de detection de sequences d'acide nucleique amplifiees de cellules par cytometrie en flux
US5843640A (en) * 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
US5747034A (en) * 1992-07-09 1998-05-05 Chiron Corporation Methods and materials for the induction of T cell anergy
US5397703A (en) * 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
WO1994001585A1 (fr) * 1992-07-14 1994-01-20 Worcester Polytechnic Institute Procede de selection de crevettes genetiquement superieures
CA2141450A1 (fr) * 1992-07-31 1994-02-17 Maureen Laney Methode d'introduction de sequences definies a l'extremite 3' des polynucleotides
JP3465903B2 (ja) * 1992-07-31 2003-11-10 ガーヴァン インスティチュート オブ メディカル リサーチ 作動因子における対立遺伝子の変動の評価
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
WO1994003624A1 (fr) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Procedes d'amplification isothermique de molecules d'acide nucleique
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US5464945A (en) * 1992-08-28 1995-11-07 Hoffmann-La Roche Inc. Oligonucleotide probes specific for the human alpha satellite locus
US6264915B1 (en) 1992-09-13 2001-07-24 The President And Fellows Of Harvard College Process for detecting potential carcinogens
US5389515A (en) * 1992-09-15 1995-02-14 Boehringer Mannheim Corporation Isolated nucleotide sequences for identifying Neisseria gonorrhoeae
JP3292387B2 (ja) * 1992-09-29 2002-06-17 株式会社エスアールエル 新規dna、それがコ−ドするポリペプチド及びそれらの検出方法
ES2126620T5 (es) * 1992-10-06 2010-05-21 Siemens Healthcare Diagnostics Products Gmbh Retrovirus del grupo de los vih y su utilizacion.
US5565339A (en) * 1992-10-08 1996-10-15 Hoffmann-La Roche Inc. Compositions and methods for inhibiting dimerization of primers during storage of polymerase chain reaction reagents
EP0672144A1 (fr) * 1992-10-20 1995-09-20 Chiron Corporation Antagonistes du recepteur d'interleukine 6
US5494794A (en) * 1992-10-20 1996-02-27 Emory University Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
GB9223035D0 (en) * 1992-11-03 1992-12-16 Kiessling Cooper Ann A Preservation of peripheral blood & semen in fixatives that inactivate human pathogens
AU5694694A (en) * 1992-12-02 1994-06-22 Denis F. Hochstrasser A method for detecting growing cells using translationally controlled tumor protein p21
US6673616B1 (en) 1992-12-07 2004-01-06 Third Wave Technologies, Inc. Methods and compositions for characterizing nucleic acids
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US7691573B2 (en) * 1992-12-07 2010-04-06 Third Wave Technologies, Inc. Cleavage of nucleic acids
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US6372424B1 (en) * 1995-08-30 2002-04-16 Third Wave Technologies, Inc Rapid detection and identification of pathogens
AU5743894A (en) * 1992-12-07 1994-07-04 Mariano E Busso Method for detecting a virus
US5614402A (en) * 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5888780A (en) * 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US5340728A (en) * 1992-12-09 1994-08-23 E. I. Du Pont De Nemours And Company Method for amplification of targeted segments of nucleic acid using nested polymerase chain reaction
US20060084092A1 (en) * 1993-01-05 2006-04-20 Gelfand David H Homogeneous assay system
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
AU6031094A (en) * 1993-01-15 1994-08-15 Public Health Research Institute Of The City Of New York, Inc., The Sensitive nucleic acid sandwich hybridization assays and kits
DE4301693A1 (de) * 1993-01-22 1994-07-28 Cytech Biomedical Inc Verfahren zur Amplifikation und Verfahren zum Nachweis von Polynucleotidsequenzen an fester Phase
US5773253A (en) * 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
US5593840A (en) * 1993-01-27 1997-01-14 Oncor, Inc. Amplification of nucleic acid sequences
DE4302459A1 (de) * 1993-01-29 1994-08-04 Bayer Ag Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren
CA2155186A1 (fr) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methodes et appareil pour le sequencage de l'adn
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
WO1994019491A1 (fr) * 1993-02-17 1994-09-01 Genetic Therapy, Inc. Detection de virus aptes a la replication
US6410277B1 (en) 1993-02-19 2002-06-25 Takara Shuzo Co., Ltd. DNA polymersases with enhanced length of primer extension
US7465539B1 (en) 1993-02-19 2008-12-16 Takara Bio, Inc. DNA polymerases with enhanced length of primer extension
US5436149A (en) * 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US5583210A (en) * 1993-03-18 1996-12-10 Pioneer Hi-Bred International, Inc. Methods and compositions for controlling plant development
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
US5643765A (en) * 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5639606A (en) * 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5736334A (en) * 1993-04-12 1998-04-07 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis B viral DNA
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5462854A (en) * 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
US5470723A (en) * 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
US5422252A (en) * 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
EP0697888B1 (fr) * 1993-05-12 2003-09-17 Chiron Corporation Motif conserve de la region e2/ns1 du virus de l'hepatite c
US6174668B1 (en) * 1993-05-14 2001-01-16 Johnson & Johnson Clinical Diagnostics, Inc. Diagnostic compositions, elements, methods and test kits for amplification and detection of two or more target DNA's using primers having matched melting temperatures
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5403707A (en) * 1993-05-14 1995-04-04 Eastman Kodak Company Diagnostic compositions, elements, methods and test kits for amplification and detection of retroviral DNA using primers having matched melting temperatures
US6709813B1 (en) 1993-05-14 2004-03-23 Ortho-Clinical Diagnostics, Inc. Diagnostic compositions, elements, methods and test kits for amplification and detection of human CMV DNA using primers having matched melting temperatures
US6080407A (en) * 1993-05-17 2000-06-27 The Picower Institute For Medical Research Diagnostic assays for MIF
CA2163211C (fr) 1993-05-17 2012-05-08 Richard J. Bucala Inhibition du facteur inhibiteur de la migration dans le traitement de maladies avec manifestation de toxicite via la cytokine
US6774227B1 (en) * 1993-05-17 2004-08-10 Cytokine Pharmasciences, Inc. Therapeutic uses of factors which inhibit or neutralize MIF activity
CA2163249A1 (fr) * 1993-05-28 1994-12-08 Henri Tiedge Bc200 rna; sondes pour ces sequences et leur utilisation
DE4344742A1 (de) * 1993-06-09 1994-12-15 Boehringer Mannheim Gmbh Verfahren zur Immobilisierung von Nukleinsäuren
US5550040A (en) 1993-06-23 1996-08-27 Hoffman-La Roche Inc. Method, reagents and kits for the detection of Neisseria gonorrhoeae
US5399719A (en) 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US6004742A (en) * 1993-06-28 1999-12-21 Cerus Corporation Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens
US5871900A (en) * 1993-06-28 1999-02-16 Cerus Corporation Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens
US5625079A (en) 1993-06-28 1997-04-29 Cerus Corporation Synthesizing psoralen compounds useful as intermediates
US5593823A (en) * 1993-06-28 1997-01-14 Cerus Corporation Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US6004741A (en) * 1993-06-28 1999-12-21 Cerus Corporation Method for the photoactivation of 4' and 5' primary aminoalkyl psoralens in platelet preparations
US6406841B1 (en) 1993-07-01 2002-06-18 Abbott Laboratories Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
US5457178A (en) * 1993-07-07 1995-10-10 Fmc Corporation Insecticidally effective spider toxin
US5512430A (en) * 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
CA2167838C (fr) * 1993-07-23 1999-11-23 Thomas B. Ryder Methodes pour ameliorer l'amplification de l'acide nucleique
EP0636413B1 (fr) * 1993-07-28 2001-11-14 PE Corporation (NY) Dispositif et procédé d'amplification d'acide nucléique
WO1995004161A1 (fr) * 1993-07-29 1995-02-09 Sergio Danilo Junho Pena Methode d'identification de la sequence nucleotidique d'un segment purifie d'adn
WO1995004064A1 (fr) 1993-07-29 1995-02-09 The Regents Of The University Of California Leurres polynucleotidiques inhibant l'expression du complexe d'histocompatibilite majeure ii, et applications
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
US6281411B1 (en) 1993-08-25 2001-08-28 Dekalb Genetics Corporation Transgenic monocots plants with increased glycine-betaine content
US6326527B1 (en) 1993-08-25 2001-12-04 Dekalb Genetics Corporation Method for altering the nutritional content of plant seed
US5780709A (en) * 1993-08-25 1998-07-14 Dekalb Genetics Corporation Transgenic maize with increased mannitol content
AU7679394A (en) * 1993-09-03 1995-03-22 Duke University A method of nucleic acid sequencing
US5859231A (en) * 1993-09-03 1999-01-12 Duke University Synthesis of oligonucleotides with boranophosphonate linkages
US6376178B1 (en) 1993-09-03 2002-04-23 Duke University Method of nucleic acid sequencing
US5426039A (en) * 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
ES2328424T3 (es) 1993-09-15 2009-11-12 Novartis Vaccines And Diagnostics, Inc. Vectores de alfavirus recombinantes.
US5597694A (en) * 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
EP2199386A1 (fr) 1993-10-08 2010-06-23 Novozymes A/S Variants d'amylase
US5658782A (en) * 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
US5912171A (en) * 1993-10-20 1999-06-15 Oregon Health Science University Amino acid transporters and uses
US5882926A (en) * 1993-10-20 1999-03-16 Oregon Health Sciences University Excitatory amino acid transporter gene and uses
ES2216004T3 (es) * 1993-10-26 2004-10-16 Thomas Jefferson University Composiciones que se unen especificamente a celulas cancerosas colorectales y procedimientos de uso de las mismas.
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US7375198B2 (en) * 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US5601990A (en) * 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
US6680378B1 (en) * 1993-10-28 2004-01-20 Invitrogen Corporation Nucleic acid marker ladder for estimating mass
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
FR2711672B1 (fr) * 1993-10-29 1995-12-08 France Etat Armement Procédé de sélection et/ou d'obtention de sondes capables de détecter de nouvelles régions à nombre variable de répétitions en tandem, sondes pouvant être ainsi obtenues et leurs utilisations.
DE4337295A1 (de) * 1993-11-02 1995-05-04 Merck Patent Gmbh Oligonukleotide für den Nachweis von Enterobacteriaceae
ATE291583T1 (de) * 1993-11-03 2005-04-15 Orchid Biosciences Inc Polymorphismus von mononukleotiden und ihre verwendung in der genanalyse
US5658783A (en) * 1993-11-08 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Mammalian methadone-specific opioid receptor gene and uses
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5589329A (en) * 1993-11-15 1996-12-31 Ambion, Inc. Methods and compositions for detecting base pair mismatches
WO1995014106A2 (fr) * 1993-11-17 1995-05-26 Id Biomedical Corporation Detection cyclique par scission de sondes de sequences d'acides nucleiques
US5474920A (en) * 1993-11-23 1995-12-12 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Modified thermo-resistant DNA polymerases
PL314522A1 (en) * 1993-11-23 1996-09-16 Ciba Corning Diagnostics Corp Application of antisense oligomers in a contamination controlling process during nucleic acids amplification reactions
US5556772A (en) * 1993-12-08 1996-09-17 Stratagene Polymerase compositions and uses thereof
US7312052B1 (en) 1993-12-08 2007-12-25 Stratagene California Polymerase compositions and uses thereof
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
ES2078174B1 (es) * 1993-12-16 1996-08-16 Univ Cantabria Metodo de diagnostico molecular para la deteccion de brucella abortus y en diferenciacion de la cepa vacunal b19.
GB9326052D0 (en) * 1993-12-21 1994-02-23 Zeneca Ltd Sequences
WO1995018236A1 (fr) * 1993-12-28 1995-07-06 Daikin Industries, Ltd. PROCEDE D'HYBRIDATION IN SITU AU MOYEN D'UNE PROTEINE RecA, ET PROTEINE RecA COMPRENANT UN MARQUEUR OU UN LIGAND UTILISEE POUR METTRE EN ×UVRE LEDIT PROCEDE
US5830686A (en) * 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US6057299A (en) * 1994-01-13 2000-05-02 Calydon, Inc. Tissue-specific enhancer active in prostate
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5840573A (en) * 1994-02-01 1998-11-24 Fields; Robert E. Molecular analyzer and method of use
CA2182517C (fr) * 1994-02-07 2001-08-21 Theo Nikiforov Extension d'amorces ligase/polymerase-a mediation de polymorphismes de mononucleotides et son utilisation dans des analyses genetiques
US5543026A (en) * 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
FR2716263B1 (fr) * 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en) * 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5928905A (en) * 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6309883B1 (en) * 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5491069A (en) * 1994-02-18 1996-02-13 The Regents Of The University Of California Biomarkers of cell senescence
DE4405810A1 (de) * 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
AU709054B2 (en) 1994-03-07 1999-08-19 Chiron Corporation Compositions for the inhibition of TNF formation and uses thereof
EP0749473B1 (fr) 1994-03-08 2005-10-12 Novozymes A/S Nouvelles cellulases alcalines
US5648271A (en) * 1994-03-11 1997-07-15 Barrskogen, Inc. Method for evaporating solvent using filter
US6033850A (en) * 1994-03-15 2000-03-07 Affymetrix, Inc. Electrochemical denaturation of double-stranded nucleic acid
AU687535B2 (en) * 1994-03-16 1998-02-26 Gen-Probe Incorporated Isothermal strand displacement nucleic acid amplification
US6110709A (en) * 1994-03-18 2000-08-29 The General Hospital Corporation Cleaved amplified modified polymorphic sequence detection methods
CA2185902A1 (fr) * 1994-03-18 1995-09-28 Federick Ausubel Methodes de detection de polymorphismes amplifies et clives des sites de restriction
US5698517A (en) * 1994-03-21 1997-12-16 University Of Hawaii, Office Of Technology Transfer And Economic Development Thyroxin-binding HSA fragments
JPH09510617A (ja) 1994-03-29 1997-10-28 ノボ ノルディスク アクティーゼルスカブ アルカリ性バチルスアミラーゼ
US7252989B1 (en) * 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
US5831065A (en) * 1994-04-04 1998-11-03 Lynx Therapeutics, Inc. Kits for DNA sequencing by stepwise ligation and cleavage
US5714330A (en) * 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
US5629167A (en) * 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
EP0755446B1 (fr) * 1994-04-25 2006-09-13 Genentech, Inc. Cardiotrophine et ses utilisations
US5585238A (en) * 1994-04-25 1996-12-17 Ciba-Geigy Corporation Detection of fungal pathogens using the polymerase chain reaction
US5705332A (en) * 1994-04-25 1998-01-06 University Of Hawaii Detection and identification of Salmonella and Shigella
DE69531612D1 (de) * 1994-04-25 2003-10-02 Avitech Diagnostics Inc Die bestimmung von mutationen durch spaltung mit resolvase
ES2078185B1 (es) * 1994-05-06 1996-08-16 Inia Procedimiento para la tipificacion molecular de patogenos virales con genoma rna y de patogenos subvirales mediante sintesis aleatoria de cdna.
ATE381624T1 (de) 1994-05-09 2008-01-15 Oxford Biomedica Ltd Retrovirale vektoren mit verminderter rekombinationsrate
US6013517A (en) 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
CA2190471A1 (fr) * 1994-05-16 1995-11-23 Carlos Eduardo Lopez-Nieto Processus, appareil et composition permettant de caracteriser des sequences de nucleotides
US5643723A (en) * 1994-05-26 1997-07-01 Roche Molecular Systems, Inc. Detection of a genetic locus encoding resistance to rifampin in mycobacterial cultures and in clinical specimens
ATE220424T1 (de) * 1994-05-28 2002-07-15 Tepnel Medical Ltd Herstellung von nukleinsaeurekopien
WO1995033075A1 (fr) * 1994-05-31 1995-12-07 Cornell Research Foundation, Inc. Procede d'identification d'echantillons d'acide nucleique preleves sur des organismes contenant de l'adn
US5698394A (en) * 1994-06-01 1997-12-16 Board Of Regents Of The University Of Nebraska Nucleotide sequences and methods for detection of Serpulina hyodysenteriae
US5658729A (en) * 1994-10-11 1997-08-19 The University Of British Columbia Method, reagent and kit for evaluating susceptibility to premature atherosclerosis
US5766889A (en) 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
US5814442A (en) * 1994-06-10 1998-09-29 Georgetown University Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid
AU2635295A (en) * 1994-06-13 1996-01-05 Henry Ford Health System A novel neuronal-neonatal gene: neuronatin
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
CA2150986C (fr) 1994-06-17 1999-11-02 Mary Kathryn Meyer Amorces et sondes d'oligonucleotides pour la detection de bacteries
US5792612A (en) * 1994-06-22 1998-08-11 Helsinki University Licensing, Ltd. Use of lipids to improve the polymerse chain reaction
DE4421901A1 (de) * 1994-06-23 1996-01-04 Bayer Ag Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
US6576236B1 (en) 1994-07-01 2003-06-10 Dana Farber Cancer Institute Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
US5545527A (en) * 1994-07-08 1996-08-13 Visible Genetics Inc. Method for testing for mutations in DNA from a patient sample
US5550020A (en) * 1994-07-08 1996-08-27 Visible Genetics Inc. Method, reagents and kit for diagnosis and targeted screening for retinoblastoma
SE9403953D0 (sv) * 1994-07-15 1994-11-16 Pharmacia Biotech Ab Sequence-based diagnosis
US5605796A (en) * 1994-07-19 1997-02-25 Behringwerke Ag Method for preventing amplification of nucleic acid contaminants in amplification mixtures using nuclease-receptor conjugates
JP2002503943A (ja) 1994-08-12 2002-02-05 ミリアド・ジェネティックス・インコーポレイテッド 17q−連鎖乳癌および卵巣癌感受性遺伝子におけるイン・ビボ突然変異および多形性
WO1996005308A1 (fr) 1994-08-12 1996-02-22 Myriad Genetics, Inc. Procede pour diagnostiquer une predisposition au cancer du sein et des ovaires
WO1996006190A2 (fr) * 1994-08-19 1996-02-29 Perkin-Elmer Corporation Procede de ligature et d'amplification associees
HUT76842A (en) 1994-08-31 1997-11-28 Du Pont Nucleotide sequences of canola and soybean palmitoyl-acp thioesterase genes and their use in the regulation of fatty acid content of the oils of soybean and canola plants
US6455251B1 (en) 1994-09-13 2002-09-24 Thomas Jefferson University Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5705366A (en) * 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5500341A (en) 1994-09-19 1996-03-19 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
US5538870A (en) * 1994-09-21 1996-07-23 Boehringer Mannheim Corporation Method for preparing nucleic acids for analysis and kits useful therefor
CA2159044A1 (fr) * 1994-09-26 1996-03-27 Falko-Guenter Falkner Methode de dosage des acides nucleiques
AT401270B (de) * 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
CA2118048C (fr) * 1994-09-30 2003-04-08 James W. Schumm Amplification multiplex de locus de sequences courtes repetees en tandem
US6479235B1 (en) 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
US7008771B1 (en) 1994-09-30 2006-03-07 Promega Corporation Multiplex amplification of short tandem repeat loci
US5843660A (en) * 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6121037A (en) 1994-10-18 2000-09-19 Stojiljkovic; Igor Bacterial hemoglobin receptor genes
US6613560B1 (en) 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US6635226B1 (en) 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6309843B1 (en) 1994-10-25 2001-10-30 The Curators Of The University Of Missouri Glycoprotein for use in determining endometrial receptivity
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
ES2314978T3 (es) 1994-11-02 2009-03-16 Nps Pharmaceuticals, Inc. Canales de sodio especificos del sistema ner5vioso periferico, dna que los codifica, exploracion de farmacos y metodos para obtenerlos y usarlos.
US6410223B1 (en) 1994-11-04 2002-06-25 The United States Of America As Represented By The Secretary Of Agriculture Direct polymerase chain reaction assay, or bio-PCR
US5693508A (en) * 1994-11-08 1997-12-02 Chang; Lung-Ji Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats
US5691132A (en) * 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
US5512441A (en) * 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
US5521299A (en) * 1994-11-22 1996-05-28 National Science Council Oligonucleotides for detection of baculovirus infection
DE4441626A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verfahren zum besonders sensitiven Nachweis von Nukleinsäuren
US6001610A (en) * 1994-11-23 1999-12-14 Roche Diagnostics, Gmbh Method for the particularly sensitive detection of nucleic acids
US5665545A (en) * 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US5876940A (en) * 1994-11-30 1999-03-02 University Of Utah Research Foundation Alleles
US5652102A (en) * 1994-12-05 1997-07-29 The United States Of America As Represented By The Secretary Of Agriculture Assay for enterohemorrhagic Escherichia coli 0157:H7 by the polymerase chain reaction
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6033851A (en) * 1994-12-09 2000-03-07 Wakunaga Seiyaku Kabushiki Kaisha Method for suppressing nonspecific hybridization in primer extension method
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US6350576B1 (en) * 1994-12-20 2002-02-26 Cold Spring Harbor Laboratory Cancer detection probes
US5919617A (en) * 1994-12-21 1999-07-06 Miami University Methods and reagents for detecting fungal pathogens in a biological sample
CA2139070C (fr) * 1994-12-23 2010-03-30 Burton W. Blais Methode pour ameliorer l'aptitude a la detection d'essais d'acide nucleique utilisant une reaction en chaine de polymerase
WO1996020287A2 (fr) * 1994-12-23 1996-07-04 Behringwerke Aktiengesellschaft Detection d'acides nucleiques par formation d'un produit catalyse par une cible
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
WO1996021144A1 (fr) * 1994-12-30 1996-07-11 Georgetown University Methode de detection fluorometrique de clivage d'acide nucleique
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6113905A (en) * 1995-01-06 2000-09-05 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6015660A (en) * 1995-01-06 2000-01-18 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6077510A (en) * 1995-01-06 2000-06-20 Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US5891629A (en) * 1995-09-28 1999-04-06 Ambion, Inc. Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids
US5602011A (en) * 1995-01-18 1997-02-11 Pharmacia Biotech Inc. Purified Thermococcus barossii DNA polymerase
WO1996023076A1 (fr) * 1995-01-27 1996-08-01 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Procedes de detection sensible de transcriptase inverse
US5565340A (en) * 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6103465A (en) * 1995-02-14 2000-08-15 The Perkin-Elmer Corporation Methods and reagents for typing HLA class I genes
US5700683A (en) * 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
US5637456A (en) * 1995-02-17 1997-06-10 The University Of Texas, Board Of Regents Rapid test for determining the amount of functionally inactive gene in a gene therapy vector preparation
US5759783A (en) * 1995-03-14 1998-06-02 Ludwig Institute For Cancer Research Method of screening for cancer by detecting messenger RNA for a MAGE-XP gene
ATE315083T1 (de) 1995-03-17 2006-02-15 Novozymes As Neue endoglukanase
US5837693A (en) * 1995-03-24 1998-11-17 The Regents Of The University Of California Intravenous hormone polypeptide delivery by salivary gland expression
US6531455B1 (en) * 1995-03-24 2003-03-11 The Regents Of The University Of California Delivery of polynucleotides by secretory gland expression
US5885971A (en) * 1995-03-24 1999-03-23 The Regents Of The University Of California Gene therapy by secretory gland expression
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US6025480A (en) * 1995-04-03 2000-02-15 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecules encoding P57KIP2
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US5780222A (en) * 1995-04-10 1998-07-14 Alpha Therapeutic Corporation Method of PCR testing of pooled blood samples
US5753787A (en) * 1995-04-10 1998-05-19 Yale University Nucleic acids encoding ancylostoma secreted protein
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6017496A (en) * 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6221615B1 (en) * 1995-05-12 2001-04-24 Apoptosis Technology, Inc. Peptides and compositions which modulate apoptosis
US5629314A (en) * 1995-05-15 1997-05-13 Gaskin; Frances C. Methods and compositions for reducing pyrimidine photoproducts
US5777093A (en) 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US6586250B1 (en) 1995-05-16 2003-07-01 Washington University Method of PCR-based gene targeting
US5693467A (en) * 1995-05-19 1997-12-02 The American Type Culture Collection Mycoplasma polymerase chain reaction testing system using a set of mixed and single sequence primers
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5876949A (en) * 1995-05-31 1999-03-02 The Trustees Of The University Of Pennsylvania Antibodies specific for fragile X related proteins and method of using the same
US5759776A (en) * 1995-06-05 1998-06-02 California Pacific Medical Center Targets for breast cancer diagnosis and treatment
US6177441B1 (en) 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
US5861494A (en) * 1995-06-06 1999-01-19 Human Genome Sciences, Inc. Colon specific gene and protein
US20040254101A1 (en) * 1995-06-06 2004-12-16 Human Genome Sciences, Inc. Colon specific gene and protein and cancer
CA2223061C (fr) * 1995-06-06 2008-04-22 Jan Vijg Procede et dispositif pour test diagnostique d'adn
US5767376A (en) * 1995-06-07 1998-06-16 University Of Hawaii At Manoa Nucleic acids encoding a papaya ACC synthase gene
US6964861B1 (en) 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US5728526A (en) * 1995-06-07 1998-03-17 Oncor, Inc. Method for analyzing a nucleotide sequence
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
JPH11506605A (ja) * 1995-06-07 1999-06-15 アボツト・ラボラトリーズ 増幅反応におけるバックグラウンドを減少させるためにプローブをマスキングする方法
US5882867A (en) * 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US6077664A (en) * 1995-06-07 2000-06-20 Promega Corporation Thermophilic DNA polymerases from Thermotoga neapolitana
US6001645A (en) * 1995-06-07 1999-12-14 Promega Corporation Thermophilic DNA polymerases from thermotoga neapolitana
US5710002A (en) * 1995-06-07 1998-01-20 Oregon State University Detection of Clavibacter michiganensis subsp. sepedonicus
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
US5756459A (en) * 1995-06-07 1998-05-26 Fmc Corporation Insecticidally effective peptides isolatable from phidippus spider venom
ZA964896B (en) 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US5824789A (en) * 1995-06-07 1998-10-20 Systemix, Inc. Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
AT402203B (de) * 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
ATE483733T1 (de) 1995-06-14 2010-10-15 Univ California Hochaffine humane antikörper gegen tumorantigene
US6361951B1 (en) * 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US6346387B1 (en) * 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
PT861261E (pt) 1995-06-28 2009-12-16 Imp Cancer Res Tech Sequências nucleotídicas e proteicas de genes delta de vertebrado e métodos nelas baseados
WO1997003196A1 (fr) * 1995-07-11 1997-01-30 Magainin Pharmaceuticals Inc. CLONAGE, DISTRIBUTION TISSULAIRE ET ANALYSE FONCTIONNELLE DE L'ISOFORME/D'ECHANGEURS Na+/H+, NHE3
ATE360808T1 (de) * 1995-07-13 2007-05-15 Applera Corp Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäuren
US5989813A (en) * 1995-07-13 1999-11-23 Molecular Innovations, Inc. Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles
US5814506A (en) * 1995-08-02 1998-09-29 New England Biolabs, Inc. Over-expression and purification of a truncated thermostable DNA polymerase by protein fusion
US5821219A (en) * 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
US5759779A (en) * 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US6248555B1 (en) 1995-08-31 2001-06-19 The General Hospital Corporation Genetic alterations related to familial alzheimer's disease
CA2227306A1 (fr) * 1995-09-01 1997-03-27 Ramot-University Authority For Applied Research And Industrial Developme Nt Ltd. Manipulation et detection de la proteine phosphatase 2c-pp2c.alpha.- expression dans des cellules cancereuses pour la prevention, la detection et la therapie du cancer
DE19533354C2 (de) * 1995-09-08 1999-07-01 Derya Dr Ozkan Verfahren und ihre Anwendungen um Nucleinsäuren sequenzspezifisch nachzuweisen und zu quantifizieren
US5750363A (en) * 1995-09-14 1998-05-12 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism and an associated apparatus
US5721112A (en) * 1995-09-14 1998-02-24 Infectech, Inc. Method of determining the presence or absence of a nonparaffinophilic microoganism in a specimen and an associated apparatus
US5663056A (en) * 1995-09-14 1997-09-02 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism and an associated apparatus
US5854013A (en) * 1995-09-14 1998-12-29 Infectech, Inc. Method of determining the presence or absence of a nonparaffinophilic microorganism in a specimen
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US6911183B1 (en) * 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5856096A (en) * 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
US7485440B2 (en) * 1995-09-27 2009-02-03 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
US5637501A (en) * 1995-09-28 1997-06-10 Infectech, Inc. Apparatus for automatically testing the antibiotic sensitivity of a paraffinophilic microorganism
EP0861323A1 (fr) 1995-10-02 1998-09-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Proteine epitheliale, adn en provenant, et leur utilisation pour la detection precoce du cancer
US5994062A (en) * 1995-10-02 1999-11-30 The United States Of America As Represented By The Department Of Health And Human Services Epithelial protein and DNA thereof for use in early cancer detection
US6277382B1 (en) 1995-10-17 2001-08-21 Oregon Health Sciences University Hemoglobin receptors from neisseriae
US6165765A (en) 1995-10-18 2000-12-26 Shanghai Institute Of Biochemistry, Chinese Academy Of Sciences DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
US6818431B1 (en) * 1995-10-18 2004-11-16 Shanghai Mendel Dna Center Co. Ltd. DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
KR19990067080A (ko) * 1995-10-27 1999-08-16 엘리엇 알. 램버그 특정 뉴클레오티드 서열의 검출방법 및 조성물
US6015664A (en) * 1995-11-03 2000-01-18 Mcw Research Foundation Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B
ZA962161B (en) * 1995-11-09 1996-09-26 Infectech Inc Method for determining the antimicrobial agent sensitivity of a paraffinophilic microorganism using various milieus and an associated apparatus
US5639675A (en) * 1995-11-09 1997-06-17 Infectech, Inc. Method of identifying a nonparaffinophilic microorganism using various milieus and an associated apparatus
US5641645A (en) * 1995-11-09 1997-06-24 Infectech, Inc. Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism using various milieus and an associated apparatus
US5707824A (en) * 1995-11-09 1998-01-13 Infectech, Inc. Method of determining the presence or absence of a paraffinophilic microorganism
DE19543065C2 (de) * 1995-11-09 2002-10-31 Gag Bioscience Gmbh Zentrum Fu Verfahren zur Genomanalyse und Mittel zur Durchführung des Verfahrens
US5772889A (en) * 1995-11-13 1998-06-30 Transgenomic, Inc. System and method for performing nucleic acid separations using liquid chromatography
US6066258A (en) * 1997-12-05 2000-05-23 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
US6355791B1 (en) 1995-11-13 2002-03-12 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
ATE219151T1 (de) 1995-11-16 2002-06-15 Michael W Dahm Verfahren zur quantifizierung von tumorzellen in einer körperflüssigkeit und dazu geeignete testkits
WO1997019193A2 (fr) 1995-11-21 1997-05-29 Yale University Amplication et detection de segments unimoleculaires
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US6136530A (en) * 1995-11-29 2000-10-24 Texas Tech University Health Sciences Center Compositions and methods for assessing risk factors in Alzheimer's disease
US5801064A (en) * 1995-12-04 1998-09-01 Foresman; Mark D. Assay methods and reagents for detecting autoantibodies
ATE238434T1 (de) 1995-12-05 2003-05-15 Jorn Erland Koch Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US5965408A (en) * 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US7018793B1 (en) 1995-12-07 2006-03-28 Diversa Corporation Combinatorial screening of mixed populations of organisms
US20030219752A1 (en) * 1995-12-07 2003-11-27 Diversa Corporation Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
US20020164580A1 (en) * 1995-12-07 2002-11-07 Diversa Corporation Combinatorial screening of mixed populations of organisms
US5910434A (en) * 1995-12-15 1999-06-08 Systemix, Inc. Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
US6048688A (en) * 1996-11-12 2000-04-11 Kimberly-Clark Corporation Method for detection of Pseudomonas aeruginosa using polymerase chain reaction
JP3455228B2 (ja) 1995-12-18 2003-10-14 ミリアド・ジェネティックス・インコーポレイテッド 第13染色体連鎖−乳癌感受性遺伝子
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
US6265152B1 (en) 1995-12-22 2001-07-24 Visible Genetics Inc. Method and kit for evaluation of HIV mutations
US6007983A (en) * 1995-12-22 1999-12-28 Visible Genetics Inc. Method and kit for evaluation of HIV mutations
US5795722A (en) * 1997-03-18 1998-08-18 Visible Genetics Inc. Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
US5888736A (en) * 1995-12-22 1999-03-30 Visible Genetics, Inc. Method, compositions and kit for detection and identification of microorganisms
US5710003A (en) * 1996-01-18 1998-01-20 Thomas Jefferson University Diagnostic test to determine the malignancy of smooth muscle tumors
EP0880598A4 (fr) 1996-01-23 2005-02-23 Affymetrix Inc Evaluation rapide de difference d'abondance d'acides nucleiques, avec un systeme d'oligonucleotides haute densite
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6613508B1 (en) * 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5763184A (en) 1996-01-30 1998-06-09 Roche Molecular Systems, Inc. Nucleotide sequence variation in the ABO glycosyltransferase gene
US6168918B1 (en) 1996-01-31 2001-01-02 American Home Products Corp. Method of detecting foreign DNA integrated in eukaryotic chromosomes
US5994143A (en) * 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US7070962B1 (en) * 1996-02-01 2006-07-04 Aventis Pharmaceuticals Inc. Positive controls in polynucleotide amplification
US5955322A (en) * 1996-02-07 1999-09-21 Mount Sinai School Of Medicine Of The City University Of New York DNA-based computer
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2574617B1 (fr) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Détection de différences entre séquences d'acide nucléique faisant appel à la réaction de détection de ligase et à des réseaux adressables
US6838256B2 (en) 1996-02-12 2005-01-04 Gene Logic Inc. Coding sequences of the human BRCA1 gene
US20030022184A1 (en) * 1996-02-12 2003-01-30 Oncormed. Inc. Coding sequences of the human BRCA1 gene
US5789201A (en) * 1996-02-23 1998-08-04 Cocensys, Inc. Genes coding for bcl-y a bcl-2 homologue
WO1997032044A1 (fr) * 1996-03-01 1997-09-04 E.I. Du Pont De Nemours And Company Procede d'amplification et de detection d'un fragment d'acide nucleique d'interet
US6255064B1 (en) 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use
ATE505485T1 (de) 1996-03-01 2011-04-15 Novo Nordisk As Appetithemmendes peptid, zusammensetzung und verwendung
CA2199213C (fr) 1996-03-11 2007-04-17 John Wesley Backus Amplification et detection des acides nucleiques cibles grace a une etape d'incubation post-amplification
EP0914462A4 (fr) * 1996-03-18 2002-05-22 Molecular Biology Resources Amplification de sequences d'acides nucleiques cibles
US5942385A (en) * 1996-03-21 1999-08-24 Sugen, Inc. Method for molecular diagnosis of tumor angiogenesis and metastasis
US5882644A (en) * 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6140305A (en) 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US7026116B1 (en) * 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6458530B1 (en) * 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
EP0907746B1 (fr) 1996-04-05 2008-02-20 Novartis Vaccines and Diagnostics, Inc. Vecteurs a base d'alphavirus de recombinaison, presentant une inhibition reduite de la synthese macromoleculaire cellulaire
US5919901A (en) * 1996-04-08 1999-07-06 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5965392A (en) * 1996-04-08 1999-10-12 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
US7223535B2 (en) * 1996-04-19 2007-05-29 Centers For Disease Control Synthetic peptides immunoreactive with hepatitis A virus antibodies
US5712127A (en) * 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
AU2692897A (en) 1996-04-30 1997-11-19 Novo Nordisk A/S Alpha-amylase mutants
US6413718B1 (en) 1996-05-01 2002-07-02 Visible Genetics Inc. Method for sequencing of nucleic acid polymers
US5776746A (en) 1996-05-01 1998-07-07 Genitope Corporation Gene amplification methods
BR9708911A (pt) 1996-05-03 1999-08-03 Abbott Lab Composto fragmento de peptídeo processo par tratar uma doença em um paciente em necessidade de terapia antioangiogênese composição polinucleotídeo único ou de duplo-filamento isolado vetor e processo para produzir um fragmento de peptídeo de kringle 5 ou proteína de fusão de kringle 5 solúvel
WO1997042506A1 (fr) 1996-05-03 1997-11-13 Thomas Jefferson University Procedes et trousses de diagnostic et compositions permettant de diagnostiquer des tumeurs colorectales et leurs metastases
EP0953052B1 (fr) 1996-05-06 2009-03-04 Oxford BioMedica (UK) Limited Vecteurs retroviraux sans croisement
US5770368A (en) * 1996-05-09 1998-06-23 Metropolitan Water District Of Southern California Cryptosporidium detection method
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
US5786144A (en) * 1996-05-13 1998-07-28 American Museum Of Natural History Method and compositions for identification of species origin of caviar
WO1997043448A2 (fr) * 1996-05-13 1997-11-20 G.D. Searle & Co. Analyse de l'expression des isoenzymes de cytochrome p450 et des enzymes de conjugason de phase ii chez le rat
US5811239A (en) * 1996-05-13 1998-09-22 Frayne Consultants Method for single base-pair DNA sequence variation detection
US5910409A (en) * 1996-05-20 1999-06-08 Miami University Methods and reagents for detecting fungal pathogens in a biological sample
US6455248B1 (en) 1996-05-20 2002-09-24 Miami University Reagents and kits for detecting fungal pathogens in a biological sample
US5948889A (en) * 1996-05-21 1999-09-07 Case Western Reserve University Compositions and methods for screening antimicrobials
WO1997044461A2 (fr) 1996-05-22 1997-11-27 Novopharm Biotech, Inc. Fragments de liaison a l'antigene detectant specifiquement des cellules cancereuses, nucleotides codant lesdits fragments, et leur utilisation pour la prophylaxie et le depistage de cancers
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
AU730633B2 (en) * 1996-05-29 2001-03-08 Phillip Belgrader Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
WO1997046706A1 (fr) 1996-06-03 1997-12-11 University Of Alberta Procedes de detection d'adn rearrange
DK1179600T3 (da) * 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
US20020115585A1 (en) * 1996-06-07 2002-08-22 Hei Derek J. Method and devices for the removal of psoralens from blood products
AU3299997A (en) * 1996-06-10 1998-01-07 Wang, Fennggang Method for randomly synthesizing biopolymers
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
JP4413999B2 (ja) 1996-07-15 2010-02-10 アメリカ合衆国 クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US20020106647A1 (en) * 1996-07-24 2002-08-08 Segal Andrew H. Nucleic acid compositions and methods of introducing nucleic acids into cells
US5853990A (en) * 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US20020137917A1 (en) * 1996-07-26 2002-09-26 University Of Maryland Biotechnology Institute Assay for perkinsus in shellfish
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
EP0942917B1 (fr) * 1996-08-14 2015-02-25 Life Technologies Corporation Méthode utilisant des compositions stables pour l'amplification et le sequencage d'acides nucleiques
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US20050064439A1 (en) * 1996-08-22 2005-03-24 Johanna Bergmann Agents for pre-symptomatic detection and therapeutic targeting of alzheimer's disease and down syndrome in humans
CA2468374C (fr) 1996-08-30 2010-12-21 Novo-Nordisk A/S Derives de glp-1
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US6312930B1 (en) 1996-09-16 2001-11-06 E. I. Du Pont De Nemours And Company Method for detecting bacteria using PCR
CA2266656A1 (fr) 1996-09-17 1998-03-26 Chiron Corporation Compositions et procedes de traitement de maladies intracellulaires
US5981274A (en) * 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US5965703A (en) * 1996-09-20 1999-10-12 Idun Pharmaceuticals Human bad polypeptides, encoding nucleic acids and methods of use
US5989873A (en) * 1996-09-24 1999-11-23 Vinayagamoorthy; Thuraiayah Method of detecting gene expression and/or of preventing such expression in cells
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
US6093695A (en) 1996-09-26 2000-07-25 Monsanto Company Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP
US5922757A (en) * 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US6808880B2 (en) * 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6475789B1 (en) * 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
JP2001523947A (ja) * 1996-10-01 2001-11-27 ジェロン コーポレイション テロメラーゼ逆転写酵素
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
EP0834569A1 (fr) 1996-10-03 1998-04-08 Roche Diagnostics GmbH Polymérase d'ADN thermostable de carboxydothermus hydrogenoformans
EP0835935A1 (fr) 1996-10-03 1998-04-15 Roche Diagnostics GmbH Polymérase d'ADN thermostable d'Anaerocellum thermophilum
EP0834571A1 (fr) * 1996-10-03 1998-04-08 Roche Diagnostics GmbH Polymérase d'ADN thermostable de Thermococcus Gorgonarius
US6855545B1 (en) 1996-10-04 2005-02-15 Lexicon Genetics Inc. Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US7332338B2 (en) 1996-10-04 2008-02-19 Lexicon Pharmaceuticals, Inc. Vectors for making genomic modifications
US6207371B1 (en) 1996-10-04 2001-03-27 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6136566A (en) * 1996-10-04 2000-10-24 Lexicon Graphics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6139833A (en) * 1997-08-08 2000-10-31 Lexicon Genetics Incorporated Targeted gene discovery
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US20040072243A1 (en) * 1996-10-11 2004-04-15 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US5814453A (en) * 1996-10-15 1998-09-29 Novartis Finance Corporation Detection of fungal pathogens using the polymerase chain reaction
BR9712348B1 (pt) 1996-10-16 2013-06-18 vetor de expressão, célula de bactéria ou levedura transformada ou transfectada, processo para produzir um polipeptídeo homólogo de fgf, composição farmacêutica, e, processos para estimular ex vivo células progenitoras de miócitos ou miócitos
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) * 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US5800997A (en) * 1996-11-01 1998-09-01 Novartis Finance Corporation Detection of maize fungal pathogens using the polymerase chain reaction
US5863731A (en) * 1996-11-01 1999-01-26 The Penn State Research Foundation Polymerase chain reaction-based diagnostic test for the detection of Xanthomonas campestris pathovar pelargonii
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998020038A1 (fr) 1996-11-05 1998-05-14 Board Of Regents, The University Of Texas System Compositions et utilisations relatives a la sentrine, une proteine de protection contre la mort cellulaire
WO1998020166A2 (fr) * 1996-11-06 1998-05-14 Sequenom, Inc. Diagnostics de l'adn fondes sur la spectrometrie de masse
US6066778A (en) * 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
US6174441B1 (en) 1996-11-13 2001-01-16 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US6471866B1 (en) 1996-11-13 2002-10-29 Transgenomic, Inc. Process for performing polynucleotide separations
US6017457A (en) * 1996-11-13 2000-01-25 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US5972222A (en) * 1996-11-13 1999-10-26 Transgenomic, Inc. Process for performing polynucleotide separations
US5997742A (en) * 1996-11-13 1999-12-07 Transgenomic, Inc. Method for performing polynucleotide separations using liquid chromatography
US6030527A (en) * 1996-11-13 2000-02-29 Transgenomic, Inc. Apparatus for performing polynucleotide separations using liquid chromatography
US6287822B1 (en) 1997-08-05 2001-09-11 Transgenomic, Inc. Mutation detection method
US6372142B1 (en) 1996-11-13 2002-04-16 Transgenomic, Inc. Column for DNA separation by matched ion polynucleotide chromatography
US7138518B1 (en) 1996-11-13 2006-11-21 Transgenomic, Inc. Liquid chromatographic separation of polynucleotides
US6482317B2 (en) 1996-11-13 2002-11-19 Transgenomic, Inc. Polynucleotide separations on polymeric separation media
US6291164B1 (en) * 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
WO1998023639A2 (fr) * 1996-11-27 1998-06-04 University Of Florida COMPOSITIONS DE TOXINES ShK ET PROCEDES D'UTILISATION
ES2317658T3 (es) 1996-11-29 2009-04-16 Third Wave Technologies, Inc. Endonucleasas fen - 1, mezclas y procedimientos de escision.
US6495692B1 (en) 1996-12-10 2002-12-17 Abbott Laboratories Helium-neon excitable reticulocyte dyes derivable from halolepidines
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
EP0951536B1 (fr) * 1996-12-12 2007-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Oligodesoxynucleotides antisens synthetiques et compositions pharmaceutiques les contenant
WO1998029569A1 (fr) * 1996-12-13 1998-07-09 Stratagene Procedes et adaptateurs permettant de generer des populations specifiques d'acides nucleiques
US6017701A (en) * 1996-12-13 2000-01-25 Stratgene Methods and adaptors for generating specific nucleic acid populations
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
DE19653494A1 (de) * 1996-12-20 1998-06-25 Svante Dr Paeaebo Verfahren zur entkoppelten, direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen unter Zugabe einer zweiten thermostabilen DNA Polymerase und dessen Anwendung
US6482590B1 (en) 1996-12-20 2002-11-19 Aventis Behring Gmbh Method for polynucleotide amplification
US6605428B2 (en) * 1996-12-20 2003-08-12 Roche Diagnostics Gmbh Method for the direct, exponential amplification and sequencing of DNA molecules and its application
DE19653439A1 (de) * 1996-12-20 1998-07-02 Svante Dr Paeaebo Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung
US5861295A (en) * 1997-01-02 1999-01-19 Life Technologies, Inc. Nucleic acid-free thermostable enzymes and methods of production thereof
US5851805A (en) * 1997-01-16 1998-12-22 Board Of Trustees Operating Michigan State University Method for producing DNA from mRNA
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6475724B1 (en) * 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ, インコーポレイテッド 光学装置
US5972638A (en) * 1997-01-31 1999-10-26 Lockheed Martin Energy Research Corp. Method for detection of buried explosives using a biosensor
US5952200A (en) * 1997-02-06 1999-09-14 University Of South Carolina Method of diagnosing cancer in human cells using a reverse transcriptase-polymerase chain reaction for identifying the presence of stromelysin-3
EP2172478A3 (fr) 1997-02-07 2010-07-28 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Facteur III neurotrophe dépendant de l'activité (ADNF III)
JP3935509B2 (ja) * 1997-02-12 2007-06-27 ワイ. チャン,ユージーン ポリマー分析のための方法および製品
US6187536B1 (en) 1997-02-18 2001-02-13 Thomas Jefferson University Methods of identifying and detecting pancreatic cancer
US6713300B1 (en) * 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
US6524795B1 (en) 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
EP1006794B1 (fr) * 1997-03-12 2007-11-28 Robert W. Esmond Procede de traitement ou de prevention de la maladie d'alzheimer
NZ337900A (en) 1997-03-18 2001-05-25 Novo Nordisk As DNA shuffling for randomised heterologous and homogenous 3' and 5' primers for construction of DNA libraries for generation of more desirable mutants
US6830887B2 (en) 1997-03-18 2004-12-14 Bayer Healthcare Llc Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
US6268165B1 (en) 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
CA2283635A1 (fr) 1997-03-21 1998-10-01 Stratagene Extraits de facteur stimulant la polymerase (pef), complexes de proteines pef, proteine pef isolee, et procedes de purification et d'identification
US5958738A (en) * 1997-03-24 1999-09-28 Roche Diagnostics Corporation Procedure for subtractive hybridization and difference analysis
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US5914394A (en) * 1997-03-27 1999-06-22 Millenium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US5955355A (en) * 1997-03-27 1999-09-21 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5866412A (en) * 1997-03-27 1999-02-02 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US5858367A (en) * 1997-03-27 1999-01-12 Case Western Reserve University Methods for screening for antimicrobials utilizing AarC and compositions thereof
US5939316A (en) * 1997-03-27 1999-08-17 Millennium Pharmaceuticals, Inc. Chromosome 18 marker
US6048689A (en) * 1997-03-28 2000-04-11 Gene Logic, Inc. Method for identifying variations in polynucleotide sequences
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
EP1705253B1 (fr) * 1997-04-03 2010-11-03 Life Technologies Corporation Compositions et procédés d'amplification en chaine par polymerase-transcriptase inverse (RT-PCR)
EP0972082A4 (fr) 1997-04-04 2007-04-25 Caliper Life Sciences Inc Analyseurs biochimiques fonctionnant en boucle fermee
DE69841719D1 (de) * 1997-04-09 2010-07-22 Danisco Lipase und Verwendung davon zur Verbesserung von Teigen und Backwaren
CA2286304C (fr) * 1997-04-10 2007-08-07 Diagnocure Inc. Pca3, genes de pca3, et procedes d'utilisation
US6054567A (en) 1997-04-11 2000-04-25 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
US6387615B2 (en) * 1997-04-11 2002-05-14 Isis Innovation Limited Methods and materials for the diagnosis or prognosis of asthma
US6080911A (en) * 1997-04-15 2000-06-27 Ohio University Mice models of growth hormone insensitivity
AU6969798A (en) 1997-04-15 1998-11-11 Baylor College Of Medicine (pasteurella haemolytica) vaccine
US5939306A (en) * 1997-04-16 1999-08-17 University Technology Corporation Osmosensing histidine kinases
ATE353964T1 (de) 1997-04-16 2007-03-15 Millennium Pharm Inc Crsp-proteine (cystein-reiche, sekretierte proteine), die dafür kodierenden nukleinsäuren und ihre verwendungen
US6716625B1 (en) 1997-04-16 2004-04-06 Claude Selitrennikoff Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use
US7622549B2 (en) * 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) * 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US20050013825A1 (en) * 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
AU7360198A (en) 1997-04-22 1998-11-13 Life Technologies, Inc. Methods for the production of aslv reverse transcriptases composed of multiple subunits
EP0981604B1 (fr) 1997-04-24 2009-01-07 University of Washington Modification genetique ciblee au moyen de vecteurs parvoviraux
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
AU7265298A (en) * 1997-04-29 1998-11-24 Trustees Of Boston University Methods and compositions for targeted dna differential display
EP1905357B1 (fr) 1997-04-30 2012-11-28 The Board Of Trustees Of The Leland Stanford Junior University Procédé servant à prendre l'image de l'apoptose in vivo
US6395539B1 (en) 1997-05-05 2002-05-28 Ohio University Composition and methods for bioremediation
US6551814B1 (en) 1997-05-05 2003-04-22 Ohio University Methods for bioremediation by degrading toluene
US7115722B1 (en) 1997-05-22 2006-10-03 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US7632508B2 (en) * 1997-05-23 2009-12-15 The United States Of America Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US20030082209A1 (en) * 2000-07-05 2003-05-01 Skiadopoulos Mario H. Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7951383B2 (en) * 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
ES2355631T3 (es) 1997-05-30 2011-03-29 Trovagene, Inc. Procedimiento para detectar secuencias de ácidos nucleicos en la orina.
US6309874B1 (en) 1997-06-04 2001-10-30 Karolinska Innovations Ab Selection marker
AU731812B2 (en) 1997-06-10 2001-04-05 Transgenomic, Inc. System and method for performing polynucleotide separations using liquid chromatography
US6056877A (en) * 1997-12-05 2000-05-02 Transgenomic, Inc. Non-polar media for polynucleotide separations
DE69841593D1 (de) 1997-06-13 2010-05-12 Bio Rad Laboratories Verfahren und Zusammensetzungen für die Diagnose und die Behandlung von Krankheiten, die mit Eisenüberschuss oder Eisenmangel assoziiert sind
US20020098190A1 (en) * 1997-06-13 2002-07-25 Malaya Chatterjee Compositions and methods for treating tumors bearing HMFG and CEA antigens
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
AU7977198A (en) 1997-06-17 1999-01-04 University Technology Corporation Neural transplantation for treating neurological disease
US6046165A (en) * 1997-06-23 2000-04-04 Ophidian Pharmaceuticals, Inc. Compositions and methods for identifying and testing TGF-β pathway agonists and antagonists
US6268133B1 (en) * 1997-06-25 2001-07-31 Invitrogen Corporation Method for isolating and recovering target DNA or RNA molecules having a desired nucleotide sequence
US6348336B1 (en) 1997-07-01 2002-02-19 Alpha Therapeutic Corporation Process for purification of PCR test samples
US6258534B1 (en) 1998-03-02 2001-07-10 Bbi Bioseq, Inc. Pressure-controlled nucleic acid hybridization
US6433137B1 (en) 1997-07-02 2002-08-13 The Regents Of The University Of California TUP1 sequences from Candida albicans and methods for screening agents for inhibiting virulence in Candida albicans using TUP1
EP0998450A1 (fr) * 1997-07-09 2000-05-10 Akzo Nobel N.V. Agents chelateurs et leurs chelates manganiques
US7662397B2 (en) * 1997-07-15 2010-02-16 The United States Of America As Represented By The Department Of Health And Human Services Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
US20030157642A1 (en) 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US20040005542A1 (en) 2001-06-22 2004-01-08 Krempl Christine D Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
US5874589A (en) * 1997-07-18 1999-02-23 Glaxo Wellcome, Inc. Methods for synthesizing diverse collections of tetramic acids and derivatives thereof
US6548642B1 (en) 1997-07-21 2003-04-15 Ohio University Synthetic genes for plant gums
US6570062B1 (en) * 1997-07-21 2003-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US7378506B2 (en) * 1997-07-21 2008-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6639050B1 (en) 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6710036B2 (en) 1997-07-25 2004-03-23 Avigen, Inc. Induction of immune response to antigens expressed by recombinant adeno-associated virus
US7068830B2 (en) * 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
EP1002264B1 (fr) 1997-07-25 2004-04-14 Affymetrix, Inc. (a Delaware Corporation) Procede d'obtention d'une base de donnees bioinformatique
US20040161409A1 (en) * 1997-07-25 2004-08-19 Kurtzman Gary J. Induction of immune response to antigens expressed by recombinant adeno-associated virus
CA2296298A1 (fr) 1997-07-25 1999-02-04 Anne M. Johnson-Flanagan Nouvelle variete de brassica
US6420108B2 (en) * 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US5827695A (en) * 1997-08-04 1998-10-27 Novartis Finance Corporation Detection of wheat fungal pathogens using the polymerase chain reaction
EP1002103B1 (fr) 1997-08-04 2007-10-17 Cell Genesys, Inc. Sequence stimulatrice de la kallicreine glandulaire chez l'homme, vecteurs comprenant cette sequence et procedes d'utilisation de ces derniers
JP2001512702A (ja) * 1997-08-05 2001-08-28 トランスジエノミツク・インコーポレーテツド 突然変異を検出するための変性マルチイオンポリヌクレオチドクロマトグラフィー
US7049101B1 (en) 1997-08-06 2006-05-23 Diversa Corporation Enzymes having high temperature polymerase activity and methods of use thereof
US7056703B2 (en) 1997-08-06 2006-06-06 Diversa Corporation Polypeptides having polymerase activity and methods of use thereof
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
DE1002138T1 (de) 1997-08-08 2001-06-07 Akzo Nobel Nv Nukleinsäuresequenzen als primer und sonden zur amplifizierung und erkennung von allen hiv-1 subtypen
FR2767337B1 (fr) 1997-08-14 2002-07-05 Pasteur Institut Sequences nucleiques de polypeptides exportes de mycobacteri es, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
US20090269814A1 (en) * 1998-05-22 2009-10-29 Murphy Patricia D Method of Analyzing a BRCA2 Gene in a Human Subject
US6027898A (en) * 1997-08-18 2000-02-22 Transgenomic, Inc. Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
DE69829857T2 (de) 1997-08-21 2006-02-02 Quark Biotech, Inc., Pleasanton Hypoxie-regulierte gene
US7973156B2 (en) * 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
US5916776A (en) * 1997-08-27 1999-06-29 Sarnoff Corporation Amplification method for a polynucleotide
CA2301942C (fr) 1997-08-27 2011-05-31 Chiron Corporation Mimetiques moleculaires des epitopes b meningococciques
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6960457B1 (en) 1997-09-04 2005-11-01 Stanford University Reversible immobilization of arginine-tagged moieties on a silicate surface
US6238905B1 (en) 1997-09-12 2001-05-29 University Technology Corporation Thermophilic polymerase III holoenzyme
US6013486A (en) * 1997-09-17 2000-01-11 Yale University Method for selection of insertion mutants
AU9400398A (en) * 1997-09-19 1999-04-05 Genetrace Systems, Inc. Dna typing by mass spectrometry with polymorphic dna repeat markers
US6764822B1 (en) 1997-09-19 2004-07-20 Sequenom, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
JP2001517433A (ja) 1997-09-24 2001-10-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非霊長類レンチウイルスベクターおよびパッケージングシステム
US6355415B1 (en) 1997-09-29 2002-03-12 Ohio University Compositions and methods for the use of ribozymes to determine gene function
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US7378244B2 (en) * 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
US6344554B1 (en) 1997-10-02 2002-02-05 Regents Of The University Of California Polynucleotide sequences from Candida albicans encoding polypeptides associated with filamentous growth
US6284496B1 (en) 1997-10-03 2001-09-04 University Of South Florida DNA vector for determining the presence of out-of-reading-frame mutations
US6103468A (en) * 1997-10-07 2000-08-15 Labatt Brewing Company Limited Rapid two-stage polymerase chain reaction method for detection of lactic acid bacteria in beer
US6187576B1 (en) 1997-10-13 2001-02-13 Novo Nordisk A/S α-amylase mutants
US6187539B1 (en) 1997-10-14 2001-02-13 Transgenomic, Inc. Analysis of nicked DNA by matched ion polynucleotide chromatography
US6573094B1 (en) 1997-10-16 2003-06-03 Baylor College Of Medicine F-box genes and proteins
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
US6875606B1 (en) 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
CN100342008C (zh) * 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US20030124555A1 (en) * 2001-05-21 2003-07-03 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
CN1163597C (zh) 1997-10-30 2004-08-25 诺维信公司 α-淀粉酶突变体
US6395470B2 (en) * 1997-10-31 2002-05-28 Cenetron Diagnostics, Llc Method for monitoring nucleic acid assays using synthetic internal controls with reversed nucleotide sequences
EP1042503A4 (fr) * 1997-10-31 2002-01-16 Transgenomic Inc Procede de detection d'adn mutant par mipc et pcr
AU1232099A (en) * 1997-11-04 1999-05-24 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
EP1900818A3 (fr) 1997-11-06 2008-06-11 Novartis Vaccines and Diagnostics S.r.l. Antigènes de Neisserial
US6294326B1 (en) 1997-11-07 2001-09-25 Abbott Laboratories Analyte detection process using dual labeled probes
US6197502B1 (en) 1997-11-17 2001-03-06 Cytos Biotechnology Ag Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property
DE29720432U1 (de) * 1997-11-19 1999-03-25 Heimberg, Wolfgang, Dr., 85560 Ebersberg Roboter
US6060310A (en) * 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US6312941B1 (en) 1997-11-26 2001-11-06 The Regents Of The University Of Michigan Compositions and methods for identifying signaling pathway agonists and antagonists
US6372130B1 (en) 1997-12-05 2002-04-16 Transgenomic, Inc. Non-polar media for polynucleotide separations
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
US6503397B2 (en) 1997-12-05 2003-01-07 Transgenomic, Inc. Non-polar media for polynucleotide separations
EP1036198B1 (fr) * 1997-12-08 2012-09-26 California Institute Of Technology Procédé de préparation des séquences de polynucléotides et de polypeptides
US6046316A (en) 1997-12-09 2000-04-04 Wayne State University Nucleic acid encoding truncated integrins
US6225053B1 (en) 1997-12-12 2001-05-01 Digene Corporation Detection of hepatitis B virus
EP1040192B1 (fr) 1997-12-18 2006-08-09 Monsanto Technology LLC PLANTES TRANSGENIQUES RESISTANT AUX INSECTES ET PROCEDES PERMETTANT D'AMELIORER L'ACTIVITE DE L'$g(d)-ENDOTOXINE CONTRE DES INSECTES CIBLES
ES2241189T3 (es) 1997-12-22 2005-10-16 Novozymes A/S Carbohidrato oxidasa y su uso para la coccion.
WO1999032627A2 (fr) * 1997-12-23 1999-07-01 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Lat de substrats de tyrosine-kinases et utilisation dudit lat pour l'identification d'agonistes/antagonistes de ces kinases
US20020177144A1 (en) * 1997-12-30 2002-11-28 Jose Remacle Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7687057B2 (en) 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6780609B1 (en) 1998-10-23 2004-08-24 Genome Therapeutics Corporation High bone mass gene of 1.1q13.3
AU1979599A (en) 1998-01-14 1999-08-02 Chiron S.P.A. (neisseria meningitidis) antigens
US6054568A (en) * 1998-01-16 2000-04-25 The Perkin-Elmer Corporation Nucleobase oligomers
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US20030166169A1 (en) * 1998-01-16 2003-09-04 Padgett Hal S. Method for constructing viral nucleic acids in a cell-free manner
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6214581B1 (en) 1998-01-16 2001-04-10 Abbott Laboratories Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
US6764830B1 (en) 1998-01-23 2004-07-20 The Regents Of The University Of California Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin proteins
AU2228599A (en) * 1998-01-26 1999-08-09 Saigene Corporation An exponential nucleic acid amplification method using a single primer of opposing polarity
CA2319170A1 (fr) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification des acides nucleiques par detection electronique
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
CN1302107C (zh) 1998-01-30 2007-02-28 吉倪塞思技术公司 与硫氧还蛋白或硫氧还蛋白还原酶基因互补的寡核苷酸序列以及将其用于调节细胞生长的方法
US20010055809A1 (en) * 1998-01-30 2001-12-27 Harpal S. Mangat Extending tissue preservation
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6617107B1 (en) 1998-02-03 2003-09-09 Xy, Inc. Specific oligonucleotide primers for detection of bovine male chromosome presence by polymerase chain reaction and method
US6238863B1 (en) 1998-02-04 2001-05-29 Promega Corporation Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers
DE19804372A1 (de) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
WO1999040208A1 (fr) * 1998-02-05 1999-08-12 The General Hospital Corporation Construction in vivo de bibliotheques d'adn
US6841347B1 (en) 1998-02-05 2005-01-11 The General Hospital Corporation In vivo construction of DNA libraries
US6420143B1 (en) * 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US5962296A (en) * 1998-02-24 1999-10-05 New England Biolabs, Inc. Method for cloning and producing Thermomicrobium roseum DNA polymerase I in E. coli
DE69942307D1 (de) 1998-02-27 2010-06-10 Novo Nordisk As N-terminal veränderte glp-1 abkömmlinge
DE69942305D1 (de) 1998-02-27 2010-06-10 Novo Nordisk As Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil
DK2305799T3 (en) 1998-02-27 2016-07-25 Novozymes As Maltogenic alpha-amylase variants
EP1060191B1 (fr) 1998-02-27 2010-04-28 Novo Nordisk A/S Derives d'analogues de glp-1
BR9908567A (pt) 1998-03-05 2000-12-12 Johnson & Johnson Res Pty Ltd Processos de detecção de ácido nucléico zimogênico e moléculas relacionadas e kits
US5912129A (en) * 1998-03-05 1999-06-15 Vinayagamoorthy; Thuraiayah Multi-zone polymerase/ligase chain reaction
EP1062512A4 (fr) 1998-03-10 2001-12-12 Univ California Procedes et outils utilises pour identifier des composes qui modulent l'atherosclerose par alteration de la liaison ldl-proteoglycane
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6787305B1 (en) 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6342351B1 (en) 1998-03-16 2002-01-29 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating chromosome-18p related disorders
US20040176572A1 (en) * 1998-03-16 2004-09-09 Freimer Nelson B. Methods of compositions for diagnosing and treating chromosome-18p related disorders
US6071737A (en) * 1998-03-16 2000-06-06 The Regents Of The University Of California Equine Neospora isolate and its uses
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6686513B1 (en) 1998-03-19 2004-02-03 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane ubi9 gene promoter sequence and methods of use thereof
US6706948B1 (en) 1998-03-19 2004-03-16 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane UBI9 gene promoter and methods of use thereof
EP1141727A2 (fr) 1998-03-20 2001-10-10 Curators Of The University Of Missouri Compositions et methodes pour un diagnostic precoce de la grossesse
US6436707B1 (en) * 1998-03-27 2002-08-20 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6808921B1 (en) * 1998-03-27 2004-10-26 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
JPH11341989A (ja) 1998-03-31 1999-12-14 Sanyo Electric Co Ltd Dna断片増幅方法、dna断片増幅装置、微生物群測定方法、微生物群分析方法および汚染物質測定方法
US6500637B1 (en) 1998-03-31 2002-12-31 The Institute Of Physical And Chemical Research Neurogenesis inducing genes
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US6022952A (en) * 1998-04-01 2000-02-08 University Of Alberta Compositions and methods for protein secretion
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6461864B1 (en) 1998-04-15 2002-10-08 Fred Hutchinson Cancer Research Center Methods and vector constructs for making non-human animals which ubiquitously express a heterologous gene
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6027623A (en) * 1998-04-22 2000-02-22 Toyo Technologies, Inc. Device and method for electrophoretic fraction
US6348573B1 (en) 1998-04-27 2002-02-19 The Regents Of The University Of Michigan Compositions and methods for identifying apoptosis signaling pathway inhibitors and activators
JPH11332562A (ja) 1998-04-28 1999-12-07 Ortho Clinical Diagnostics Inc 組織試料およびパラフィン包埋組織から核酸を抽出するための改良方法
US6068974A (en) * 1998-04-29 2000-05-30 Klann; Richard Chris Specific, highly sensitive, nested PCR detection scheme for the pseudorabies virus
US7018827B1 (en) 1998-04-30 2006-03-28 The United States Of America As Represented By The Department Of Health And Human Services Nucleic acids of the M antigen gene of Histoplasma capsulatum, antigens, vaccines and antibodies, methods and kits for detecting histoplasmas
EP2261356A3 (fr) 1998-05-01 2012-01-04 Novartis Vaccines and Diagnostics, Inc. Antigènes de Neisseria meningitidis et compositions
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
DK1614475T3 (da) 1998-05-01 2007-09-17 Gen Probe Inc Indretning til omröring af væskeindholdet i en beholder
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6232065B1 (en) 1998-05-06 2001-05-15 Case Western Reserve University Analysis of gene family expression
US6686163B2 (en) 1998-05-06 2004-02-03 Gene Logic Inc. Coding sequence haplotype of the human BRCA1 gene
US20080206206A1 (en) 1998-05-07 2008-08-28 University Of South Florida Bone marrow-derived neuronal cells
US6225456B1 (en) 1998-05-07 2001-05-01 University Technololy Corporation Ras suppressor SUR-5
US6391544B1 (en) 1998-05-15 2002-05-21 Abbott Laboratories Method for using unequal primer concentrations for generating nucleic acid amplification products
WO1999060381A1 (fr) * 1998-05-16 1999-11-25 The Perkin-Elmer Corporation Instrument servant a surveiller l'amplification en chaine par polymerase (pcr) d'adn
US7498164B2 (en) * 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US6468743B1 (en) 1998-05-18 2002-10-22 Conagra Grocery Products Company PCR techniques for detecting microbial contaminants in foodstuffs
US6485648B1 (en) 1998-05-18 2002-11-26 Transgenomic, Inc. MIPC column cleaning system and process
US6506889B1 (en) 1998-05-19 2003-01-14 University Technology Corporation Ras suppressor SUR-8 and related compositions and methods
US6225063B1 (en) 1998-05-22 2001-05-01 University Technology Corporation RNA channels in biological membranes
US6183998B1 (en) 1998-05-29 2001-02-06 Qiagen Gmbh Max-Volmer-Strasse 4 Method for reversible modification of thermostable enzymes
DE19824900B4 (de) * 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
EP2287318B1 (fr) 1998-06-10 2014-01-22 Novozymes A/S Mannanases
US6489095B2 (en) * 1998-06-15 2002-12-03 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US6441149B1 (en) 1998-06-15 2002-08-27 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US7153655B2 (en) * 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
US6214187B1 (en) 1998-06-18 2001-04-10 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US7052833B1 (en) 1998-06-23 2006-05-30 Board Of Regents, The University Of Texas System Absorptive hypercalciuria locus on human chromosome 1
AU770663B2 (en) * 1998-06-23 2004-02-26 Board Of Regents, The University Of Texas System Absorptive hypercalciuria locus on human chromosome 1
US6242235B1 (en) 1998-06-24 2001-06-05 Promega Corp. Polymerase stabilization by polyethoxylated amine surfactants
US20040229363A1 (en) * 1998-06-24 2004-11-18 Ed Nolan High efficiency transfection based on low electric field strength, long pulse length
US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US6835867B1 (en) * 1998-06-24 2004-12-28 Richard P. Woychik Allelic series of genomic modifications in cells
US6344443B1 (en) 1998-07-08 2002-02-05 University Of South Florida Peptide antagonists of tumor necrosis factor alpha
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US7605149B1 (en) 1998-07-13 2009-10-20 University Of South Florida Modulation of the phospholipase A2 pathway as a therapeutic
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
EP1098996A1 (fr) 1998-07-20 2001-05-16 Yale University Procede pour detecter des acides nucleiques au moyen de ligature a mediation par cibles d'amorces bipartites
US7498156B2 (en) 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US7049110B2 (en) 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
AU752215B2 (en) * 1998-07-21 2002-09-12 Dupont Nutrition Biosciences Aps Foodstuff
US7700353B2 (en) * 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
EP1806362B1 (fr) 1998-07-28 2010-07-21 The Regents of the University of California Acides nucléiques codant un récepteur couplé avec une protéine G impliquée dans la transduction sensorielle
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
DK1100534T3 (da) 1998-07-30 2008-03-10 Xy Inc System til ikke-kirurgisk kunstig insemination af heste
US7002003B1 (en) 1998-07-30 2006-02-21 University Of South Florida Method for the inhibition of function of STAT transcription factors
JP2002521070A (ja) * 1998-07-31 2002-07-16 ジェン−プローブ・インコーポレーテッド 可逆的阻害プローブ
US20070161010A1 (en) * 1998-08-04 2007-07-12 Gjerde Douglas T Methods and compositions for mutation analysis
US6699986B2 (en) 1998-08-04 2004-03-02 Ortho-Clinical Diagnostics, Inc. Electrophoretic separation of nucleic acids from proteins at low ph
US6455692B1 (en) 1998-08-04 2002-09-24 Transgenomic, Inc. Method of concentrating polynucleotides using MIPC
ES2352451T3 (es) 1998-08-06 2011-02-18 Duke University Urato oxidasa.
NZ509974A (en) 1998-08-07 2003-10-31 Univ Washington Immunological herpes simplex virus antigens and methods for use thereof
WO2000010579A1 (fr) 1998-08-18 2000-03-02 California Skin Research Institute Detection de facteurs biologiques dans l'epiderme
ES2310047T3 (es) 1998-08-18 2008-12-16 The Regents Of The University Of California Antagonistas del receptor del factor de crecimiento epidermico para el tratamiento de la hipersecrecion de mucosidad en los pulmones.
EP1104481B1 (fr) 1998-08-19 2011-04-20 Monsanto Technology LLC Vecteurs d'expression pour plantes
US6180408B1 (en) 1998-08-21 2001-01-30 Washington University Fluorescence polarization in nucleic acid analysis
US6214602B1 (en) 1998-08-28 2001-04-10 Promega Corporation Host cells for expression of clostridial toxins and proteins
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
US7029861B1 (en) 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
WO2000015779A2 (fr) 1998-09-15 2000-03-23 Yale University Clonage moleculaire a amplification selon le modele du cercle roulant
US6255082B1 (en) 1998-09-15 2001-07-03 Yale University Artificial long terminal repeat vectors
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
US20040199544A1 (en) * 2000-11-02 2004-10-07 Affymetrix, Inc. Method and apparatus for providing an expression data mining database
EP1114188A2 (fr) 1998-09-18 2001-07-11 University of Nebraska-Lincoln Balayage a haute resolution de genome
DK1115862T3 (da) 1998-09-23 2009-11-16 Zymogenetics Inc Cytokinreceptor Zalpha11
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
IL142094A0 (en) 1998-09-29 2002-03-10 Gamida Cell Ltd Methods of controlling proliferation and differentiation of stem and progenitor cells
US6197510B1 (en) 1998-10-01 2001-03-06 Bio-Id Diagnostic Inc. Multi-loci genomic analysis
US6743906B1 (en) 1998-10-02 2004-06-01 Board Of Regents, The University Of Texas PPP2R1B is a tumor suppressor
AU6074999A (en) 1998-10-14 2000-05-01 Agriculture And Agrifood Canada Hybrid alfalfa ((medicago sativa))
US6413780B1 (en) * 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
GB9822777D0 (en) 1998-10-20 1998-12-16 Tepnel Medical Ltd Template chain reaction
EP1131338B1 (fr) * 1998-10-21 2005-03-02 The University Of Kansas Center For Research, Inc. Procede de production de proteine invasine hautement purifiee et utilisation de cette proteine
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6361947B1 (en) 1998-10-27 2002-03-26 Affymetrix, Inc. Complexity management and analysis of genomic DNA
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
WO2000026343A2 (fr) 1998-10-30 2000-05-11 Case Western Reserve University Promoteurs specifiques du tissu et animaux transgeniques pour la selection de produits pharmaceutiques
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US20060205034A1 (en) * 1998-10-30 2006-09-14 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
US20030027998A1 (en) * 1998-10-30 2003-02-06 Holtzman Douglas A. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
US6489542B1 (en) 1998-11-04 2002-12-03 Monsanto Technology Llc Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids
EP1873260B1 (fr) 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Procédé pour la synthèse d'acides nucléiques
AU1619400A (en) 1998-11-10 2000-05-29 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plantphenotypes
CA2350882C (fr) 1998-11-12 2011-02-22 Invitrogen Corporation Reactifs de transfection
WO2000029008A2 (fr) * 1998-11-16 2000-05-25 Board Of Regents, The University Of Texas System Induction de lymphocytes t specifiques du vih
WO2000029596A1 (fr) 1998-11-17 2000-05-25 Monsanto Company Plantes metabolisant les phosphonates
TR200101497T2 (tr) 1998-11-27 2001-11-21 Novozymes A/S Lipolitik enzim varyantları
DE19854946C2 (de) 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
DK1137773T3 (da) 1998-12-07 2008-12-08 Zymogenetics Inc Væsktfaktorhomolog ZVEGF3
CA2255850C (fr) 1998-12-07 2000-10-17 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Appareil de thermocyclage rotatif
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
EE05627B1 (et) * 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
WO2000037504A2 (fr) 1998-12-23 2000-06-29 Pfizer Inc. Anticorps monoclonaux humains diriges contre l'antigene ctla-4
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
CA2360347C (fr) 1998-12-31 2013-05-07 Chiron Corporation Expression amelioree de polypeptides hiv et production de particules de type viral
US20020031802A1 (en) * 2000-05-12 2002-03-14 Yi Hu Novel seven transmembrane proteins and polynucleotides encoding the same
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
ATE439437T1 (de) * 1999-01-05 2009-08-15 Univ Boston Verbessertes klonierungsverfahren
DE60044223D1 (de) 1999-01-19 2010-06-02 Maxygen Inc Durch oligonukleotide-vermittelte nukleinsäuren-rekombination
WO2000042182A1 (fr) 1999-01-19 2000-07-20 Lexicon Genetics Incorporated Proteines mammiferes de type cortexine et polynucleotides codant celles-ci
US20040235107A1 (en) * 1999-01-29 2004-11-25 Ramot At Tel Aviv University Ltd. Biosynthesis of TA antibiotic
EP1026248A3 (fr) 1999-01-29 2002-09-18 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Groupe de gènes
KR100294374B1 (ko) * 1999-01-30 2001-07-03 김재종 Dna 함유 잉크 및 그의 제조방법
IL144084A0 (en) * 1999-02-03 2002-05-23 Biosante Pharmaceuticals Inc Therapeutic calcium phosphate particles and methods of manufacture and use
US20090130718A1 (en) * 1999-02-04 2009-05-21 Diversa Corporation Gene site saturation mutagenesis
NZ513303A (en) 1999-02-04 2003-03-28 Technion Res & Dev Foundation Three dimensional plug flow bioreactor, and its use for the maintenance and expansion of hemopoietic stem cells and/or progenitor cells
US6605432B1 (en) 1999-02-05 2003-08-12 Curators Of The University Of Missouri High-throughput methods for detecting DNA methylation
US7135284B1 (en) 1999-02-05 2006-11-14 Integrated Dna Technologies, Inc. Primer extension methods for production of high specific activity nucleic acid probes
US6395472B1 (en) 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
US6156515A (en) 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
EP1153037A1 (fr) * 1999-02-09 2001-11-14 Lexicon Genetics Incorporated Proteines humaines bruleuses de graisses excedentaires et polynucleotides les codant
US7745216B2 (en) * 1999-02-10 2010-06-29 Curis, Inc. Methods and reagents for treating glucose metabolic disorders
DK1189629T3 (da) 1999-02-10 2011-01-03 Curis Inc Peptid YY (PYY) til behandling af glucosestofskiftesygdomme
US7384387B1 (en) 1999-02-11 2008-06-10 Maxygen, Inc. High throughput mass spectrometry
WO2000047762A2 (fr) 1999-02-12 2000-08-17 Stemcells, Inc. Cellule souche enrichie de systeme nerveux central et populations de geniteurs, et methodes d'identification, d'isolation et d'enrichissement de telles populations
US20030068635A1 (en) * 1999-02-16 2003-04-10 Boehringer Mannheim Gmbh Determination of an analyte using two labels
US6153389A (en) * 1999-02-22 2000-11-28 Haarer; Brian K. DNA additives as a mechanism for unambiguously marking biological samples
AU752817B2 (en) 1999-02-25 2002-10-03 Exact Sciences Corporation Methods for preserving DNA integrity
AU3382800A (en) 1999-02-26 2000-09-14 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
US6221595B1 (en) 1999-03-01 2001-04-24 Syngenta Participations Ag Detection of Monilinia spp. using the polymerase chain reaction
WO2000052027A1 (fr) 1999-03-02 2000-09-08 Invitrogen Corporation Compositions et methodes de clonage recombinatoire d'acides nucleiques
US6187566B1 (en) 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
CA2366921C (fr) 1999-03-09 2013-12-17 Zymogenetics, Inc. Nouvelle cytokine ligand zalpha11
US6316192B1 (en) 1999-03-11 2001-11-13 Jianhua Luo Method for enrichment of unique DNA fragments through cyclical removal of PCR adapter attached to DNA fragments whose sequences are shared between two DNA pools
US20040259145A1 (en) * 1999-03-11 2004-12-23 Marion Wood Compositions and methods for the modification of gene expression
US20110047644A1 (en) * 1999-03-11 2011-02-24 Marion Wood Compositions and methods for the modification of gene transcription
NZ514025A (en) * 1999-03-11 2004-02-27 Genesis Res & Dev Corp Ltd Compositions and methods for the modification of gene transcription
CA2365263A1 (fr) * 1999-03-12 2000-09-21 Mcgill University Technique permettant d'accroitre l'aptitude au traitement de la polymerase adn ou arn dependante et compositions associees
US6440715B1 (en) 1999-03-12 2002-08-27 New England Biolabs, Inc. Method for cloning and expression of Rhodothermus Obamensis DNA polymerase I large fragment in E. coli
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
EP1165586A4 (fr) * 1999-03-15 2003-05-28 Univ Jefferson GENE TCL-1b ET PROTEINE, PROCEDES ET COMPOSITIONS S'Y RAPPORTANT
EP1163268B1 (fr) 1999-03-15 2011-05-11 Novo Nordisk A/S Separation de glp-1 et de peptides associes par chromatographie d'echange d'ions
WO2000055312A2 (fr) * 1999-03-17 2000-09-21 The University Of Tennessee Research Corporation Fabrication et utilisation de bibliotheques d'adnc microclonaux non clones
IL145417A0 (en) 1999-03-18 2002-06-30 Exiqon As Detection of mutations in genes by specific lna primers
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
CA2367912A1 (fr) 1999-03-19 2000-09-28 Genencor International, Inc. Plaque d'essais a trous traversants multiples pour criblage a haut debit
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6630333B1 (en) * 1999-03-23 2003-10-07 Invitrogen Corporation Substantially pure reverse transriptases and methods of production thereof
BRPI0009362B8 (pt) 1999-03-30 2019-08-20 Novozymes As variante de uma alfa-amilase precursora, e, uso de uma variante de alfa-amilase
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
AU3419200A (en) 1999-03-31 2000-10-23 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
ES2532606T3 (es) 1999-03-31 2015-03-30 Novozymes A/S Polipéptidos con actividad de alfa-amilasa alcalina y ácidos nucleicos que los codifican
ATE295430T1 (de) 1999-03-31 2005-05-15 Us Gov Health & Human Serv Typisierung von humanen enteroviren
US6383753B1 (en) 1999-03-31 2002-05-07 Regents Of The University Of Michigan Yeast mammalian regulators of cell proliferation
US6368834B1 (en) 1999-04-06 2002-04-09 Genome Technologies, Llc PCR genome walking with synthetic primer
WO2000061808A2 (fr) 1999-04-09 2000-10-19 Exact Laboratories, Inc. Procedes de detection d'acides nucleiques revelateurs de cancer
WO2000060932A1 (fr) * 1999-04-09 2000-10-19 Mcgill University Animal transgenique non humain dont les cellules germinales et les cellules somatiques contiennent une mutation knockout dans l'adn codant pour 4e-bp1
US6309833B1 (en) 1999-04-12 2001-10-30 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6531302B1 (en) 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
WO2000062036A1 (fr) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification et separation de sequences d'acide nucleique a l'aide de technologies d'amplification par deplacement de brin et de micropuce bioelectronique
CN100491530C (zh) 1999-04-13 2009-05-27 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒嵌合呼吸道合胞病毒疫苗
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
CA2370976C (fr) 1999-04-20 2009-10-20 Illumina, Inc. Detection de reactions d'acide nucleique sur microsupports de billes en reseau
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20020110809A1 (en) * 1999-04-30 2002-08-15 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
CA2368194A1 (fr) * 1999-04-30 2000-11-09 University Of Florida Ribozymes fournis par virus adeno-associes pour la decouverte de fonctions geniques
AU4685900A (en) 1999-04-30 2000-11-17 La Jolla Institute For Allergy And Immunology Methods for preventing reactivation of latent virus and controlling virus replication
CA2370122C (fr) * 1999-05-04 2011-04-26 Ortho-Clinical Diagnostics, Inc. Capture rapide et efficace d'adn dans un prelevement sans recours a un reactif de lyse cellulaire
US20020095031A1 (en) * 1999-05-04 2002-07-18 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
US6270970B1 (en) 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
US20050169896A1 (en) * 1999-05-14 2005-08-04 Henry Ford Health System Bone marrow transplantation for treatment of stroke
US6974684B2 (en) * 2001-08-08 2005-12-13 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040023874A1 (en) * 2002-03-15 2004-02-05 Burgess Catherine E. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US8017112B2 (en) 1999-05-14 2011-09-13 Henry Ford Health System Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases
US20040229779A1 (en) * 1999-05-14 2004-11-18 Ramesh Kekuda Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
PT1183035E (pt) * 1999-05-14 2015-03-04 Ford Henry Health System Transplante de medula óssea para tratamento de acidente vascular cerebral
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
PT1054018E (pt) 1999-05-18 2009-02-16 Dyax Corp Bibliotecas de fragmentos fab e métodos para a sua utilização
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6589737B1 (en) * 1999-05-21 2003-07-08 Invitrogen Corporation Compositions and methods for labeling of nucleic acid molecules
US9486429B2 (en) * 1999-06-01 2016-11-08 Vanderbilt University Therapeutic methods employing nitric oxide precursors
US6346382B1 (en) 1999-06-01 2002-02-12 Vanderbilt University Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
US6787318B1 (en) * 1999-06-01 2004-09-07 Roskamp Research Institute, Llc Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US20040067490A1 (en) * 2001-09-07 2004-04-08 Mei Zhong Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US6610906B1 (en) * 1999-06-09 2003-08-26 The Regents Of The University Of Michigan Nucleotide sequences for gene regulation and methods of use thereof
US6869767B1 (en) 1999-06-11 2005-03-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection
US7655423B2 (en) * 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
CA2377373C (fr) * 1999-06-14 2011-05-10 Henry Ford Health System Donneurs d'oxyde nitrique induisant la neurogenese
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
JP2004529312A (ja) 1999-06-18 2004-09-24 ガメラ バイオサイエンス コーポレイション 小型化均一アッセイ用のデバイスおよび方法
CA2377707A1 (fr) 1999-06-22 2000-12-28 Invitrogen Corporation Amorces et procedes ameliores destines a la detection et a la discrimination d'acides nucleiques
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US7183405B2 (en) 1999-06-25 2007-02-27 Syn Gen, Inc. Compositions and methods for labeling oligonucleotides
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
CA2435411A1 (fr) * 1999-06-25 2001-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusale M Procede permettant d'induire une angiogenese au moyen de micro-organes
US6200781B1 (en) 1999-06-25 2001-03-13 Integrated Genetic Devices, Ltd. Apparatus, system and method for automated execution and analysis of biological and chemical reactions
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
JP2003508022A (ja) 1999-06-30 2003-03-04 インターリューキン ジェネティックス インコーポレイテッド Il−1炎症性ハプロタイプと関連する病気の診断および治療方法
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6297014B1 (en) 1999-07-02 2001-10-02 Cedars-Sinai Medical Center Genetic test to determine non-responsiveness to statin drug treatment
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
CN100354425C (zh) * 1999-07-09 2007-12-12 美国政府健康及人类服务部 减毒的人-牛嵌合呼吸道合胞病毒疫苗的生产
US7820182B2 (en) * 1999-07-09 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions
CA2378661A1 (fr) 1999-07-09 2001-01-18 Alexander C. Schmidt Vaccins attenues de virus chimeres de parainfluenza humain-bovin (piv)
US6455290B1 (en) 1999-07-09 2002-09-24 Pharmacia Italia S.P.A. Tankyrase homolog protein (THP), nucleic acids, and methods related to the same
CN101550410A (zh) 1999-07-09 2009-10-07 诺维信公司 葡糖淀粉酶变体
MXPA02000490A (es) * 1999-07-13 2004-09-27 Us Gov Health & Human Serv Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras.
US6533912B2 (en) 1999-07-13 2003-03-18 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
AU773679B2 (en) 1999-07-16 2004-06-03 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US7094378B1 (en) 2000-06-15 2006-08-22 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US7220747B2 (en) 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6458536B1 (en) * 1999-07-23 2002-10-01 The Regents Of The University Of California Modified SSCP method using sequential electrophoresis of multiple nucleic acid segments
WO2001007665A2 (fr) 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Determination de sequences d'acides nucleiques par detection electronique
US6379930B1 (en) 1999-07-30 2002-04-30 Applied Gene Technologies, Inc. Stabilization of nucleic acid amplification cocktails
SK1502002A3 (en) * 1999-07-30 2002-07-02 Epidauros Biotechnologie Ag A polynucleotide, a vector, a host cell, method for producing molecular variant mdr-1 protein, mdr-1 protein, an antibody, a nucleic acid molecule and a transgenic animal containing the same and the use thereof
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
EP1210358A4 (fr) * 1999-08-13 2005-01-05 Univ Brandeis Detection d'acides nucleiques
US6232104B1 (en) 1999-08-17 2001-05-15 Dade Behring Inc. Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
US6875582B1 (en) 1999-08-19 2005-04-05 Omniscience Pharmaceuticals, Inc. Methods and targets of antibiotic resistance
AT410218B (de) 1999-08-20 2003-03-25 Baxter Ag Verfahren zur herstellung eines qualitätsgesicherten pools biologischer proben
CA2925551A1 (fr) 1999-08-23 2001-03-01 Dana-Farber Cancer Institute, Inc. Pd-1, recepteur de b7-4, et son utilisation
EP2829609A1 (fr) 1999-08-24 2015-01-28 E. R. Squibb & Sons, L.L.C. Anticorps CTLA-4 humains et leurs utilisations
US7605238B2 (en) * 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
WO2001014592A2 (fr) 1999-08-25 2001-03-01 Clarity Biosciences, Inc. Identification d'organismes par detection d'acide nucleique intronique ou de proteines codees
US20090018081A1 (en) * 1999-08-25 2009-01-15 Allergan, Inc. Activatable clostridial toxins
US20080032931A1 (en) * 1999-08-25 2008-02-07 Steward Lance E Activatable clostridial toxins
US7740868B2 (en) * 1999-08-25 2010-06-22 Allergan, Inc. Activatable clostridial toxins
ATE348178T1 (de) * 1999-08-25 2007-01-15 Allergan Inc Aktivierbare rekombinante neurotoxine
DE60040794D1 (de) * 1999-08-27 2008-12-24 Matrix Technologies Corp Verfahren zur Immobilisierung von Oligonukleotiden auf festem Trägermaterial
US6290831B1 (en) 1999-08-30 2001-09-18 Integrated Genetic Devices, Ltd. Electrophoretic system for real time detection of multiple electrophoresed biopolymers
WO2001016149A2 (fr) 1999-08-30 2001-03-08 Roche Diagnostics Gmbh Composes de 2-azapurines et leur utilisation
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
EP2206786A1 (fr) 1999-08-31 2010-07-14 Novozymes A/S Nouvelles protéases et variantes associées
US6846626B1 (en) * 1999-09-01 2005-01-25 Genome Technologies, Llc Method for amplifying sequences from unknown DNA
US6716614B1 (en) * 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US6225093B1 (en) 1999-09-07 2001-05-01 Decode Genetics Ehf. Detection of C4A deletion by long range PCR
AU783968B2 (en) * 1999-09-08 2006-01-05 Lexicon Genetics Incorporated Human G-protein coupled 7 transmembrane receptor and polynucleotides encoding the same
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
KR20070112295A (ko) 1999-09-10 2007-11-22 제론 코포레이션 올리고뉴클레오티드 엔3'→피5' 티오포스포라미데이트,이의 합성 및 용도
DK1431303T3 (en) 1999-09-13 2014-02-17 Nugen Technologies Inc A composition for isothermal linear amplification of polynucleotide sequences
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6783933B1 (en) 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6998232B1 (en) 1999-09-27 2006-02-14 Quark Biotech, Inc. Methods of diagnosing bladder cancer
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
JP2003510075A (ja) * 1999-09-29 2003-03-18 ディグノキュアー・インコーポレーテッド 良性および悪性の前立腺組織におけるpca3メッセンジャーrna種
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
EP1235932A2 (fr) 1999-10-08 2002-09-04 Protogene Laboratories, Inc. Procede et appareil destines a produire un grand nombre de reactions au moyen d'une plaque matrice
EP1222269A1 (fr) 1999-10-12 2002-07-17 Lexicon Genetics Incorporated Proteines humaines de la famille des recepteurs de ldl et polynucleotides les codant
ATE444532T1 (de) 1999-10-13 2009-10-15 Sequenom Inc Verfahren zur identifizierung von polymorphen genetischen markern
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
AU1198701A (en) * 1999-10-13 2001-04-23 Lexicon Genetics Incorporated Novel human membrane proteins
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
JP2003527833A (ja) 1999-10-14 2003-09-24 クロンテック・ラボラトリーズ・インコーポレーテッド 花虫類に由来する発色団/蛍光体、およびそれらの使用法
US6297226B1 (en) 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6855806B1 (en) * 1999-10-15 2005-02-15 Curagen Corporation Thymosin beta 10-like proteins and nucleic acids encoding same
JP2004500045A (ja) * 1999-10-18 2004-01-08 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトタンパクおよびそれをコードするポリヌクレオチド
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
EP1287162A2 (fr) 1999-10-21 2003-03-05 Case Western Reserve University Profilage de l'expression genetique d'une affection intestinale inflammatoire
CA2388599A1 (fr) * 1999-10-22 2001-05-03 Pharmacia & Upjohn Company Recepteurs couples a la proteine de drosophila g, acides nucleiques et procedes apparentes
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US6436633B1 (en) 1999-10-22 2002-08-20 The Pennsylvania State University Human xenografts for microbicide testing and anatomical modeling
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US7838225B2 (en) 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
EP2975127A1 (fr) 1999-10-29 2016-01-20 GlaxoSmithKline Biologicals SA Peptites antigènes de neisseria
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
AU1472501A (en) * 1999-11-05 2001-05-14 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および/または多型の検出方法
WO2001034838A1 (fr) 1999-11-08 2001-05-17 Eiken Kagaku Kabushiki Kaisha Methode de detection d'une variation ou d'un polymorphisme
EP1231830A4 (fr) 1999-11-10 2005-05-11 Univ Washington Compositions et procedes de modulation de la division cellulaire d'une plante
EP1980614A3 (fr) 1999-11-10 2009-04-08 Novozymes A/S Variantes d'alpha-amylase comme le fungamyl
EP2264439A3 (fr) 1999-11-12 2011-01-19 E.I. Du Pont De Nemours And Company Fluoromètre avec source lumineuse à faible génération de chaleur
EP1921440A3 (fr) 1999-11-12 2008-06-04 E.I. Dupont De Nemours And Company Fluoromètre avec source lumineuse à faible génération de chaleur
US6852986B1 (en) * 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US7030228B1 (en) 1999-11-15 2006-04-18 Miltenyi Biotec Gmbh Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
CA2388865A1 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
HUP0203386A3 (en) * 1999-11-17 2010-01-28 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
CA2394229C (fr) 1999-11-26 2010-04-13 Mcgill University Loci pour epilepsie generalisee idiopathique, leurs mutations, et methode utilisant ceux-ci pour evaluer, diagnostiquer, pronostiquer ou traiter l'epilepsie
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
WO2001042781A2 (fr) * 1999-12-07 2001-06-14 Exact Sciences Corporation Detection de neoplasmes aerodigestifs supracoliques
CA2393447A1 (fr) * 1999-12-07 2001-06-14 Lexicon Genetics Incorporated Nouvelles proteines membranaires humaines et polynucleotides codant pour ces proteines
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US20020110831A1 (en) * 1999-12-10 2002-08-15 Schlag Edward William Method and apparatus for controlling an electric current through bio-molecules
AU785483B2 (en) 1999-12-10 2007-09-20 Invitrogen Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US20030148301A1 (en) * 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
US6458538B1 (en) 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
CA2394984C (fr) 1999-12-16 2008-11-18 Monsanto Technology Llc Nouvelles constructions d'expressions vegetales
US20030166057A1 (en) * 1999-12-17 2003-09-04 Hildebrand William H. Method and apparatus for the production of soluble MHC antigens and uses thereof
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US20060035338A1 (en) * 1999-12-17 2006-02-16 Pure Protein Llc Method and apparatus for the production of soluble MHC antigens and uses thereof
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US20060276629A9 (en) * 1999-12-17 2006-12-07 Hildebrand William H Purification and characterization of soluble human HLA proteins
US7521202B2 (en) * 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
WO2001046417A2 (fr) * 1999-12-22 2001-06-28 Lexicon Genetics Incorporated Nouvelles proteines membranaires humaines et polynucleotides codant pour elles
AT409382B (de) 1999-12-22 2002-07-25 Baxter Ag Verfahren zur detektion, unterscheidung und quantifizierung von freien und eingekapselten nukleinsäuren in einer probe
WO2001046422A1 (fr) 1999-12-23 2001-06-28 Zymogenetics, Inc. La cytokine zcyto18
EP1255860A2 (fr) 1999-12-29 2002-11-13 Mergen Ltd. Procedes d'amplification et de detection de plusieurs polynucleotides sur un support en phase solide
US7250252B2 (en) * 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
US6544506B2 (en) * 2000-01-05 2003-04-08 Yeda Research & Development Co. Ltd. Veto cells effective in preventing graft rejection and devoid of graft versus host potential
US20020015951A1 (en) * 2000-01-06 2002-02-07 Bader Joel S. Method of analyzing a nucleic acid
JP2004502402A (ja) * 2000-01-06 2004-01-29 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼおよびそれをコードするポリヌクレオチド
AU2001230912A1 (en) * 2000-01-11 2001-07-24 The Board Of Regents Of The University Of Nebraska Identification of virulence determinants
WO2001051634A1 (fr) * 2000-01-12 2001-07-19 Lexicon Genetics Incorporated Nouvelles proteines membranaires humaines et polynucleotides codant pour ces proteines
US6350599B1 (en) 2000-01-12 2002-02-26 Novozymes A/S Pullulanase variants and methods for preparing such variants with predetermined properties
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US6287779B1 (en) 2000-01-20 2001-09-11 E. & J. Gallo Winery Detection of fermentation-related microorganisms
AU2001225441A1 (en) * 2000-01-24 2001-07-31 Agricultural Research Organization The Volcani Center Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
AU2001234538A1 (en) * 2000-01-24 2001-07-31 Dzgenes, L.L.C. Nitric oxide synthase gene diagnostic polymorphisms
US20030022318A1 (en) * 2000-01-25 2003-01-30 Epiclone, Inc. Method for thermocycling amplification of nucleic acid sequences and the generation of related peptides thereof
US6541225B1 (en) * 2000-01-26 2003-04-01 Raven Biotechnologies, Inc. Methods and compositions for generating human monoclonal antibodies
CA2398107C (fr) * 2000-01-28 2013-11-19 Althea Technologies, Inc. Procedes d'analyse de l'expression genique
AU2001234709A1 (en) * 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System Method of preparing a sensor array
US6844321B2 (en) * 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue
CA2399633A1 (fr) * 2000-02-04 2001-08-09 Lexicon Genetics Incorporated Nouvelles proteines membranaires humaines et les polynucleotides les codant
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
WO2001060393A1 (fr) * 2000-02-16 2001-08-23 Bechtel Bwxt Idaho, Llc Destruction selective de cellules infectees par le virus de l'immunodeficience humaine
EP1259624B1 (fr) 2000-02-17 2008-05-14 Qiagen GmbH Nouvelles acide nucleique polymerases chimeriques thermostables
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001062797A2 (fr) * 2000-02-23 2001-08-30 Pharmacia & Upjohn Company Nouveaux recepteurs couples a la proteine g
GB0004312D0 (en) 2000-02-23 2000-04-12 Oxagen Limited Test and model for inflammatory disease
US6498026B2 (en) 2000-02-25 2002-12-24 Hercules Incorporated Variant galactose oxidase, nucleic acid encoding same, and methods of using same
EP2143796A3 (fr) 2000-02-29 2010-03-17 Millennium Pharmaceuticals, Inc. Récepteurs couplés à la protéine G 1983, 52881, 2398, 45449, 50289, et 52872, et leurs utilisations
US6872552B2 (en) * 2000-02-29 2005-03-29 Burt D. Ensley Method of reconstituting nucleic acid molecules
EP1995330A1 (fr) 2000-03-01 2008-11-26 Epoch Biosciences, Inc. Oligonucléotides modifiées pour discrimination de désadaptation
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
EP1944310A3 (fr) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Oligonucléotides modifiées pour discrimination de désadaptation
US6436677B1 (en) 2000-03-02 2002-08-20 Promega Corporation Method of reverse transcription
US6632645B1 (en) * 2000-03-02 2003-10-14 Promega Corporation Thermophilic DNA polymerases from Thermoactinomyces vulgaris
JP2003525634A (ja) * 2000-03-03 2003-09-02 キュラジェン コーポレイション Fctrxと命名されたタンパク質およびこれをコードする核酸
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US20040009510A1 (en) * 2000-03-06 2004-01-15 Scott Seiwert Allosteric nucleic acid sensor molecules
US20030065155A1 (en) * 2000-03-06 2003-04-03 Nassim Usman Nucleic acid sensor molecules
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
EP1262547A4 (fr) 2000-03-07 2004-12-01 Chiba Prefecture Sequences d'acides nucleiques presentant une expression accrue dans le neuroblastome benin par rapport au neuroblastome humain acritique
US6833240B2 (en) 2000-03-08 2004-12-21 Mcgill University Very low density lipoprotein receptor polymorphisms and uses therefor
EP2221365A1 (fr) 2000-03-08 2010-08-25 Novozymes A/S Variantes avec propriétés altérées
WO2001068674A2 (fr) * 2000-03-13 2001-09-20 Monsanto Technology Llc Proteines recombinantes contenant des unites recurrentes
US6528060B1 (en) 2000-03-16 2003-03-04 Genzyme Corporation Therapeutic compounds
WO2001070767A2 (fr) * 2000-03-20 2001-09-27 Genzyme Corporation Composes therapeutiques anti-melanome
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
CA2403681A1 (fr) * 2000-03-21 2001-09-27 Genzyme Corporation Composes therapeutiques anti-cytomegalovirus
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US20040234967A1 (en) * 2000-03-24 2004-11-25 Moskowitz David W. Diagnostic polymorphisms of tgf-beta-rii promoter
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US20040170992A1 (en) * 2000-03-24 2004-09-02 Moskowitz David W. Diagnostic polymorphisms of tgf-beta1 promoter
EP1950313A3 (fr) 2000-03-27 2010-12-08 GlaxoSmithKline LLC Détection d'agents viables
WO2001072768A2 (fr) 2000-03-27 2001-10-04 Technion Research And Development Foundation Ltd. Complexes majeurs d'histocompatibilite monocatenaires de classe 1, constructions les codant et leurs methodes de production
DE60140865D1 (de) 2000-03-27 2010-02-04 Univ Jefferson Zusammensetzungen und methoden zur identifizierung von krebszellen
US6677146B1 (en) * 2000-03-28 2004-01-13 Replidyne, Inc. Thermophilic polymerase III holoenzyme
JP3628232B2 (ja) * 2000-03-31 2005-03-09 三洋電機株式会社 微生物識別方法、微生物識別装置、微生物識別用データベースの作成方法および微生物識別プログラムを記録した記録媒体
AU2001253129A1 (en) * 2000-04-03 2001-10-15 Biolink Partners, Inc. Reversible chemical modification of nucleic acids and improved method for nucleic acid hybridization
US20020015998A1 (en) * 2000-04-06 2002-02-07 Gabriel Vogeli Novel G protein-coupled receptors
EP1275715B1 (fr) * 2000-04-07 2015-07-15 Eiken Kagaku Kabushiki Kaisha Procede d'amplification et d'detection d'acide nucleique par utilisation d'acide nucleique a double brin en tant que modele
US7129326B2 (en) * 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
JP4966470B2 (ja) * 2000-04-14 2012-07-04 ダニスコ・ユーエス・インコーポレーテッド 選択性標的化方法
US20020052021A1 (en) * 2000-04-17 2002-05-02 Charlotte Soderberg Novel G protein-coupled receptors
DE60133190T2 (de) 2000-04-21 2009-04-02 CORIXA CORP., Wilmington Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen
US6248567B1 (en) 2000-04-24 2001-06-19 Wisconsin Alumni Research Foundation Template-specific termination in a polymerase chain reaction
AU2001259156A1 (en) * 2000-04-27 2001-11-07 Lexicon Genetics Incorporated Novel membrane proteins and polynucleotides encoding the same
IL135884A (en) * 2000-04-30 2005-08-31 Yissum Res Dev Co Method for measuring non-transferrin bound iron
US7262006B1 (en) 2000-05-01 2007-08-28 Ortho-Clinical Diagnostics, Inc. Rapid and efficient capture of DNA from sample without using cell lysing reagent
EP1283910A4 (fr) * 2000-05-04 2005-03-09 Dzgenes Llc Polymorphismes du promoteur tgf beta-rii
US20040005554A1 (en) * 2000-05-08 2004-01-08 Tayar Nabil El Novel glycoproteins and methods of use thereof
US20030032784A1 (en) * 2000-05-08 2003-02-13 Peter Lind Novel G protein-coupled receptors
US20030219786A1 (en) * 2000-08-11 2003-11-27 Applied Research Systems Ars Holding N.V. Novel glycoproteins and methods of use thereof
EP2258171B1 (fr) 2000-05-09 2019-07-10 Xy, Llc Cytomètre à flux pour différencier populations de spermatozoïdes portant un chromosome X et un chromosome Y
EP1282714A2 (fr) * 2000-05-10 2003-02-12 Bristol-Myers Squibb Company Polypeptides a base de 5'-monophosphate deshydrogenase inosine modifiee et leurs utilisations
US6680172B1 (en) 2000-05-16 2004-01-20 Regents Of The University Of Michigan Treatments and markers for cancers of the central nervous system
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
US6977161B2 (en) * 2000-10-14 2005-12-20 Eragen Biosciences, Inc. Solid support assay systems and methods utilizing non-standard bases
AU7125401A (en) 2000-05-19 2001-12-03 David J Marshall Materials and methods for detection of nucleic acids
US6573370B1 (en) * 2000-05-19 2003-06-03 Regents Of The University Of Michigan PON3 and uses thereof
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP1297112A2 (fr) 2000-05-22 2003-04-02 PHARMACIA & UPJOHN COMPANY Nouvelles metalloproteinases matricielles
US20020003001A1 (en) * 2000-05-24 2002-01-10 Weigl Bernhard H. Surface tension valves for microfluidic applications
US20030009016A1 (en) * 2000-05-25 2003-01-09 Shimkets Richard A. Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
JP2004511211A (ja) 2000-05-26 2004-04-15 インヴィトロジェン コーポレーション 耐熱性逆転写酵素およびその使用
US7078208B2 (en) 2000-05-26 2006-07-18 Invitrogen Corporation Thermostable reverse transcriptases and uses thereof
US6790667B1 (en) * 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
JP2004503217A (ja) 2000-05-31 2004-02-05 ジェンザイム・コーポレーション 卵巣癌のための治療化合物
US20020155471A1 (en) * 2000-05-31 2002-10-24 Nicolette Charles A. Compounds for therapy and diagnosis and methods for using same
AU2001264764A1 (en) 2000-05-31 2001-12-11 Genzyme Corporation Therapeutic anti-melanoma compounds
US7700359B2 (en) * 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
AU2001275346A1 (en) 2000-06-05 2001-12-17 General Hospital Corporation Compositions, kits, and methods for identification and modulation of type i diabetes
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
EP2351853A1 (fr) 2000-06-06 2011-08-03 Life Technologies Corporation Procédé et dispositif de multipléxage de réactions d'amplification
US7230092B2 (en) 2000-06-06 2007-06-12 Luminex Molecular Diagnostics, Inc. Capture moieties for nucleic acids and uses thereof
US6214557B1 (en) 2000-06-06 2001-04-10 Washington University Cold sensitive mutant DNA polymerases
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
JP2004502412A (ja) 2000-06-08 2004-01-29 ザ センター フォー ブラッド リサーチ インコーポレーティッド 免疫グロブリンを介した再灌流障害を抑制するための方法および組成物
WO2001094417A2 (fr) * 2000-06-09 2001-12-13 Lexicon Genetics Incorporated Nouvelles proteines humaines a sept domaines transmembranaires et polynucleotides les codant
EP1734050A3 (fr) 2000-06-12 2012-12-05 University Of Saskatchewan Immunisation de bovins laitiers à l'aide de la protéine GapC contre l'infection à streptocoque
US20040168209A1 (en) * 2000-06-12 2004-08-26 Alejandro Abuin Novel murine polynucleotide sequences and mutant cells and mutant animals defined thereby
ES2305087T3 (es) 2000-06-15 2008-11-01 Novartis Vaccines And Diagnostics, Inc. Polinucleotidos relacionados con el cancer de colon.
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
AU8574901A (en) 2000-06-16 2001-12-24 Syngenta Participations Ag Detection of mycosphaerella using the polymerase chain reaction
US7259244B2 (en) 2000-06-16 2007-08-21 Nerviano Medical Sciences S.R.L. Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same
US6689564B2 (en) 2000-06-16 2004-02-10 The Regents Of The University Of California Mutations in IKKγ
BRPI0100752B1 (pt) 2000-06-22 2015-10-13 Monsanto Co moléculas e pares de moléculas de dna, processos para detectar molécula de dna e para criar um traço tolerante a glifosato em plantas de milho, bem como kit de detecção de dna
WO2002000907A1 (fr) 2000-06-23 2002-01-03 Novozymes A/S Technique relative a une integration a copies multiples chromosomique stable de genes
DK1325115T3 (en) 2000-06-26 2016-11-21 Zymogenetics Inc CYTOKINRECEPTOR ZCYTOR17
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE455186T1 (de) 2000-06-26 2010-01-15 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
WO2002000174A2 (fr) 2000-06-28 2002-01-03 Corixa Corporation Compositions et methodes pour le traitement et le diagnostic du cancer du poumon
EP1320599A2 (fr) 2000-06-28 2003-06-25 Genetics Institute, LLC Molecules pd-l2: nouveaux ligands pour pd-1 et leurs utilisations
US6420144B1 (en) 2000-06-28 2002-07-16 Salus Therapeutics, Inc. Method for automated molecular cloning
EP1939293A3 (fr) 2000-06-30 2008-07-09 ZymoGenetics, Inc. Protéine ZCYTO21 d'interféron
AU2001289617A1 (en) * 2000-06-30 2002-01-08 Epigenomics Ag Diagnosis of diseases associated with signal transduction
EP1299557B1 (fr) 2000-06-30 2007-10-03 Qiagen GmbH Amplification de signal par sondes i lollipop /i
EP1307551A2 (fr) 2000-07-05 2003-05-07 PHARMACIA & UPJOHN COMPANY Canaux ioniques humains
CA2414403A1 (fr) * 2000-07-06 2002-01-17 The Regents Of The University Of California Procede destine au diagnostic et au traitement de troubles mentaux
GB0016516D0 (en) * 2000-07-06 2000-08-23 Owen Mumford Ltd Improvements relating to needle protection devices
FR2811323B1 (fr) * 2000-07-07 2006-10-06 Fuma Tech Gmbh Materiau hybride, utilisation dudit materiau hybride et procede de sa fabrication
US6958214B2 (en) * 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
DK1325125T3 (da) 2000-07-10 2013-09-08 Univ Texas Tumorundertrykkende gener af chromosomerne 3P21.3
ATE349551T1 (de) 2000-07-11 2007-01-15 Kirk Hogan Verfahren und zusammensetzungen zur bestimmung von perioperativen genomprofile
US20050201981A1 (en) * 2004-03-10 2005-09-15 Chih-Ping Liu Method of optimizing treatment with interferon-tau
US20050084478A1 (en) * 2000-10-17 2005-04-21 Chih-Ping Liu Combination therapy using interferon-tau
US20050226845A1 (en) * 2004-03-10 2005-10-13 Chih-Ping Liu Method of treatment using interferon-tau
US7431920B2 (en) * 2000-07-19 2008-10-07 Pepgen Corporation Method of treating IL-10 deficiency
US20040247565A1 (en) * 2000-07-19 2004-12-09 Chih-Ping Liu Method of treatment using interferon-tau
US7105154B2 (en) * 2000-07-19 2006-09-12 Pepgen Corporation Method of treatment using interferon-tau
US20050118137A1 (en) * 2000-07-19 2005-06-02 Chih-Ping Liu Method of treatment using interferon-tau
US20050118138A1 (en) * 2000-07-19 2005-06-02 Chih-Ping Liu Method of treatment using interferon-tau
JP2006213597A (ja) * 2000-07-19 2006-08-17 Pepgen Corp インターフェロン−タウを用いるc型肝炎ウイルスの処置のための組成物およびモニタリングの方法
HUP0300810A2 (hu) 2000-07-20 2003-08-28 M.G.V.S. Ltd. Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása
US6878861B2 (en) * 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
WO2002008468A1 (fr) * 2000-07-25 2002-01-31 Dz Genes Llc Polymorphismes de diagnostic destines au promoteur tgf-beta1
EP1305446A4 (fr) * 2000-07-25 2004-10-06 Dz Genes Llc Diagnostic de polymorphismes du promoteur ecnos
US20040023259A1 (en) * 2000-07-26 2004-02-05 Luca Rastelli Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
JP4855632B2 (ja) 2000-08-01 2012-01-18 ノボザイムス アクティーゼルスカブ 変更された性質を有するα−アミラーゼ突然変異体
JP2005503101A (ja) 2000-08-01 2005-02-03 オレゴン ヘルス アンド サイエンス ユニバーシティ 哺乳動物のdnaを結合する膜結合タンパク質をコードする遺伝子およびその使用
US7662791B2 (en) 2000-08-02 2010-02-16 University Of Southern California Gene silencing using mRNA-cDNA hybrids
US20080242627A1 (en) * 2000-08-02 2008-10-02 University Of Southern California Novel rna interference methods using dna-rna duplex constructs
US7238795B2 (en) * 2000-08-03 2007-07-03 Roche Molecular Systems, Inc. Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
ES2387329T3 (es) 2000-08-08 2012-09-20 Technion Research And Development Foundation Ltd. Composiciones farmacéuticas y procedimientos útiles para modular la angiogénesis
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
EP1311686A2 (fr) 2000-08-14 2003-05-21 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Modifications de env, gag, et pol de vih a pouvoir immunogene augmente aux fins d'immunisation genetique
US20030032019A1 (en) * 2000-08-15 2003-02-13 Peter Lind Novel G protein-coupled receptors
WO2002014560A1 (fr) 2000-08-16 2002-02-21 Whatman, Inc. Dispositifs filtrants de reduction leucocytaire pour la medecine transfusionnelle utilises en tant que source de materiel genetique pour etudes de genotypage
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
PL360990A1 (en) 2000-08-17 2004-09-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US20020187494A1 (en) * 2000-08-17 2002-12-12 Nicolette Charles A. PAR-3 compounds for therapy and diagnosis and methods for using same
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
AU2001286792A1 (en) * 2000-08-22 2002-03-04 Lexicon Genetics Incorporated Novel human 7TM proteins and polynucleotides encoding the same
EP1197550A3 (fr) * 2000-08-25 2002-11-20 Pfizer Products Inc. Méthodes et compositions pour diagnostiquer et traiter des troubles associés à l'angiogenèse
US6759525B2 (en) 2000-08-25 2004-07-06 The United States Of America As Represented By The Department Of Health And Human Services Protein kinase A and carney complex
US6803211B2 (en) 2000-08-25 2004-10-12 Pfizer Inc. Methods and compositions for diagnosing and treating disorders involving angiogenesis
EP1352089B1 (fr) * 2000-08-25 2006-12-06 Lovelace Respiratory Research Institute Methode de detection de cancer par reaction de polymerisation en chaine specifique de la methylation imbriquee
EP1683874A3 (fr) 2000-08-29 2006-10-11 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Méthode pour l'isolement de gènes codant pour des protéines à fonction spécifique et pour le criblage d'agents pharmaceutiques actifs
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
WO2002018660A2 (fr) * 2000-08-31 2002-03-07 Mayo Foundation For Medical Education And Research Detection du virus varicelle-zona
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
US6548251B1 (en) 2000-09-05 2003-04-15 Fidelity Systems, Inc. Inhibition of molecular and biological processes using modified oligonucleotides
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7025120B2 (en) * 2000-09-05 2006-04-11 Oldenburg Kevin R Rapid thermal cycling device
US20030017491A1 (en) * 2000-09-14 2003-01-23 Zuo-Rong Shi Chromogenic in situ hybridization methods, kits, and compositions
US20020058265A1 (en) * 2000-09-15 2002-05-16 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6844152B1 (en) * 2000-09-15 2005-01-18 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
WO2002023202A2 (fr) * 2000-09-18 2002-03-21 Genzyme Corporation Procede pour identifier des cibles d'anticorps therapeutiques associees a une reaction therapeutique
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
US7829276B2 (en) * 2000-09-18 2010-11-09 Thomas Jefferson University Methods of using CRCA-1 as a stomach and esophageal cancer marker
PT1319079E (pt) 2000-09-21 2012-12-21 Basf Se Xilanases de talaromyces
US20020086313A1 (en) * 2000-09-25 2002-07-04 Kilbane John J. Application of bioinformatics for direct study of unculturable microorganisms
US6916635B2 (en) * 2000-10-02 2005-07-12 The Research Foundation Of State University Of New York Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
US20040209303A1 (en) * 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
AU2002211477A1 (en) * 2000-10-05 2002-04-15 Case Western Reserve University Suppressor of human breast cancer cell growth
DE10049211A1 (de) * 2000-10-05 2002-04-18 Qiagen Gmbh Thermostabile Polymerase aus Thermococcus pacificus
AU2002213096B2 (en) 2000-10-06 2007-03-29 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
ATE433107T1 (de) * 2000-10-10 2009-06-15 Univ Oklahoma Vergleichende ligandenabbildung aus mhc-positiven zellen
US20070099182A1 (en) * 2000-10-10 2007-05-03 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
US20090062512A1 (en) * 2000-10-10 2009-03-05 Hildebrand William H Comparative ligand mapping from MHC class I positive cells
WO2002031197A1 (fr) 2000-10-10 2002-04-18 Wunderink Richard G Methode d'identification d'un risque accru de mort par pneumonie communautaire
US20050003483A1 (en) * 2000-10-10 2005-01-06 Hildebrand William H. Comparative ligand mapping from MHC class 1 positive cells
US6951739B2 (en) * 2000-10-12 2005-10-04 Marical, Inc. Polyvalent cation-sensing receptor in atlantic salmon
US7101988B2 (en) * 2000-10-12 2006-09-05 Marical, Inc. Polyvalent cation-sensing receptor in Atlantic salmon
US6979558B2 (en) * 2000-10-12 2005-12-27 Marical, Inc. Polyvalent cation-sensing receptor in Atlantic salmon
US6979559B2 (en) * 2000-10-12 2005-12-27 Marical, Inc. Polyvalent cation-sensing receptor in atlantic salmon
US20040091994A1 (en) 2000-10-13 2004-05-13 Carsten Andersen Alpha-amylase variant with altered properties
US7045283B2 (en) 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
WO2002057414A2 (fr) * 2000-10-20 2002-07-25 Expression Diagnostics, Inc. Evaluation du niveau d'expression leucocytaire
WO2002034910A2 (fr) * 2000-10-25 2002-05-02 University Of Alberta Procede pour moduler l'absorption de granzyme b et identifier ses modulateurs
EP2189473A3 (fr) 2000-10-27 2010-08-11 Novartis Vaccines and Diagnostics S.r.l. Acides nucléiques et protéines dérivés des groupes de streptocoques A et B
JP2004533221A (ja) * 2000-10-27 2004-11-04 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト7tmタンパクおよびそれをコードするポリヌクレオチド
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
CA2427701A1 (fr) * 2000-10-30 2002-05-10 Lexicon Genetics Incorporated Nouvelles proteines humaines 7tm et polynucleotides codant pour ces proteines
US6902933B2 (en) * 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US6897067B2 (en) * 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
JP2005505231A (ja) * 2000-11-03 2005-02-24 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 表面トランスフェクションおよび発現法
US7226764B1 (en) 2000-11-08 2007-06-05 The Board Of Trustees Operating Michigan State University Compositions and methods for the synthesis and subsequent modification of uridine-5′-diphosphosulfoquinovose (UDP-SQ)
US7575924B2 (en) * 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
US6544782B1 (en) 2000-11-13 2003-04-08 Synthegen Systems pREM: a positive selection vector system for direct PCR cloning
WO2002070755A2 (fr) * 2000-11-15 2002-09-12 Third Wave Technologies, Inc. Endonucleases fen
US20020177138A1 (en) * 2000-11-15 2002-11-28 The United States Of America , Represented By The Secretary, Department Of Health And Human Services Methods for the indentification of textual and physical structured query fragments for the analysis of textual and biopolymer information
EP1343973B2 (fr) 2000-11-16 2020-09-16 California Institute Of Technology Appareil et procedes pour effectuer des dosages et des criblages a haut rendement
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
DK2186530T3 (da) 2000-11-17 2013-07-29 Vascular Biogenics Ltd Promotere, der udviser endothelcellespecificitet og fremgangsmåder til anvendelse heraf
US7858559B2 (en) 2000-11-17 2010-12-28 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US7309573B2 (en) * 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
US6673332B1 (en) 2000-11-22 2004-01-06 The Regents Of The University Of California Assays for inhibitors of neuronal transport of Alzheimer's amyloid precursor protein
AU2002241524A1 (en) 2000-11-28 2002-06-11 Wyeth Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
EP2295606A1 (fr) 2000-11-28 2011-03-16 Wyeth LLC Analyse d'expression d'acides nucléiques KIAA et polypeptides utilisés dans le diagnostic et le traitement du cancer de la prostate
US20020137076A1 (en) * 2000-11-28 2002-09-26 Shultz John W. RNA polymers and uses thereof
US20040082068A1 (en) * 2000-11-28 2004-04-29 Lawrence Kleiman Incorporation and priming function of trnalys in hiv and related viruses
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
AU2002220018A1 (en) 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US20040052769A1 (en) * 2000-11-30 2004-03-18 Yair Reisner Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease
US20080261220A1 (en) * 2000-11-30 2008-10-23 Third Wave Technologies, Inc. Nucleic Acid Detection Assays
ATE510214T1 (de) 2000-11-30 2011-06-15 Crawford Healthcare Holdings Ltd Krankheitsdiagnose
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
CA2429769C (fr) * 2000-12-07 2016-04-26 Board Of Regents, The University Of Texas System Procedes de traitement mettant en application mda-7 humain
ES2397627T3 (es) 2000-12-07 2013-03-08 Novartis Vaccines And Diagnostics, Inc. Retrovirus endógenos regulados por aumento en el cáncer de próstata
ATE460472T1 (de) 2000-12-08 2010-03-15 Life Technologies Corp Verfahren und zusammensetzungen zur synthese von nukleinsäuremolekülen unter verwendung multipler erkennungsstellen
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
EP1366191A2 (fr) 2000-12-11 2003-12-03 Alexion Pharmaceuticals, Inc. Oligonucleotides emboites contenant une structure en epingle a cheveux pour l'amplification des acides nucleiques
AU2002230788A1 (en) * 2000-12-11 2002-06-24 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
US6958213B2 (en) * 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
CA2430329A1 (fr) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methodes et compositions de generation de copies multiples de sequences d'acides nucleiques et methodes de detection correspondantes
US20030215813A1 (en) * 2000-12-14 2003-11-20 Roberds Steven L. Human ion channels
DE60140317D1 (de) * 2000-12-14 2009-12-10 Gen Probe Inc Verfahren und kits zur verbesserung der hybridisierungsraten von polynukleotiden
US8273713B2 (en) * 2000-12-14 2012-09-25 Amylin Pharmaceuticals, Llc Methods of treating obesity using PYY[3-36]
US20070026433A1 (en) 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
AU2002228921A1 (en) * 2000-12-18 2002-07-01 Renessen Llc Arcelin-5 promoter and uses thereof
US6706867B1 (en) 2000-12-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services DNA array sequence selection
EP1345961A2 (fr) * 2000-12-21 2003-09-24 Genzyme Corporation Composes antigeniques a base de proteine cytokeratine-18 (ck-18), pour la therapie et le diagnostic, et procedes d'utilisation correspondants
WO2002049662A2 (fr) * 2000-12-21 2002-06-27 Mcgill University Procede de protection des cellules contre l'apoptose et analyses visant a identifier des agents modulant l'apoptose
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
CA2447832C (fr) * 2000-12-22 2012-09-25 Jamshid Tanha Bibliotheques d'affichage de phages de fragments vh humains
WO2002052043A1 (fr) * 2000-12-26 2002-07-04 Takara Bio Inc. Procede de detection d'un micro-organisme pathogene
CA2433680A1 (fr) * 2000-12-28 2002-08-01 Gregory M Arndt Suppression de gene mediee par arn bicatenaire
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
CA2433674A1 (fr) * 2001-01-05 2002-07-11 Invitrogen Corporation Methode de quantification relative d'acides nucleiques lies
US6964849B2 (en) 2001-01-11 2005-11-15 Curagen Corporation Proteins and nucleic acids encoding same
US20020122820A1 (en) * 2001-01-16 2002-09-05 Hildebrand William H. Soluble MHC artificial antigen presenting cells
IL157006A0 (en) * 2001-01-17 2004-02-08 Univ Ramot Chitinases, derived from carnivorous plants, polynucleotide sequence encoding thereof, and methods of isolating and using same
US20040043928A1 (en) * 2001-08-02 2004-03-04 Ramesh Kekuda Therapeutic polypeptides, nucleic acids encoding same, and methods of use
ES2185472B1 (es) 2001-01-23 2004-10-16 Universidad De Salamanca (O.T.R.I.) Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas.
US6635451B2 (en) 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
US20030165866A1 (en) * 2001-01-31 2003-09-04 Cockerill Franklin R. Detection of bordetella
US20050202098A1 (en) 2001-01-31 2005-09-15 Tolaren Disease therapy using dying or dead cells
AU2002230061A1 (en) * 2001-01-31 2002-08-12 Tolaren Induction of tolerance by apoptotic and/or necrotic cells
JP2004529323A (ja) * 2001-01-31 2004-09-24 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム ミクロ機械加工した化学センサ・アレイ内に材料を閉じ込めるための方法および装置
AU2002243751A1 (en) * 2001-01-31 2002-08-12 Mayo Foundation For Medical Education And Research Detection of herpes simplex virus
CN1500144A (zh) * 2001-02-06 2004-05-26 �����﹤����ʽ���� 扩增的核酸及其固定化制品
JP2004522444A (ja) * 2001-02-07 2004-07-29 クリストーフ クチャルツィーク, 多温度一本鎖コンフォメーション多型性
IL141392A0 (en) * 2001-02-12 2002-03-10 Gene Bio Applic Ltd Orientation-directed construction of plasmids
CA2438130A1 (fr) 2001-02-13 2002-08-22 Children's Hospital Research Foundation Analyse quantitative rapide par pcr du virus d'epstein-barr
US20030113263A1 (en) * 2001-02-13 2003-06-19 Oregon Health And Sciences University, A Non-Profit Organization Methods and reagents for using mammalian melanocortin receptor antagonists to treat cachexia
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6566067B2 (en) * 2001-02-14 2003-05-20 Synthegen Systems, Inc. High fidelity PCR cloning
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
EP1367136A4 (fr) * 2001-02-15 2005-01-12 Takara Bio Inc Procede de detection de polymorphisme de nucleotide
CA2438661C (fr) 2001-02-15 2011-05-31 University Of Chicago Methodes de criblage d'agents modifiant le repliement des proteines utilisant la levure
US6620586B2 (en) 2001-02-20 2003-09-16 Applied Gene Technologies, Inc. Methods and compositions for analyzing nucleic acids
US6867021B2 (en) * 2001-02-20 2005-03-15 Board Of Trustees Of Michigan State University Multiplex RT-PCR/PCR for simultaneous detection of bovine coronavirus, bovine rotavirus, Cryptosporidium parvum, and Escherichia coli
IL157492A0 (en) * 2001-02-21 2004-03-28 Univ Oklahoma Hla ligand database utilizing predictive algorithms and methods of making and using same
WO2002067984A2 (fr) 2001-02-22 2002-09-06 University Of Florida Materiaux et methodes permettant de detecter, de prevenir et de traiter une infection retrovirale a vih ou a vif
ATE426041T1 (de) * 2001-02-27 2009-04-15 Virco Bvba Zirkulare sonden amplifizierung (cpa) von zirkularisierten nucleinsaure-molekulen
US20040170998A1 (en) * 2001-03-01 2004-09-02 Honeycutt Rhonda J. Methods of making and uses of compositions that modulate intronic region-encoded protein function
US6849449B2 (en) * 2001-03-01 2005-02-01 Regents Of The University Of Michigan Orphanin FQ receptor nucleic acids
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
EP1236804A1 (fr) * 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh Méthode pour la détermination d'un acide nucléique utilisant un controle
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121335A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents associated with host versus graft and graft versus host rejections
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
JP4542312B2 (ja) 2001-03-09 2010-09-15 ニューゲン テクノロジーズ, インコーポレイテッド Rna配列の増幅のための方法および組成物
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US6645720B2 (en) * 2001-03-09 2003-11-11 Syngenta Participations Ag Detection of fungal pathogens using the polymerase chain reaction
EP1417487B1 (fr) * 2001-03-09 2007-10-17 The Board Of Regents Of The University Of Oklahoma Tests d'epitopes faisant appel au systeme hla
WO2002072892A1 (fr) * 2001-03-12 2002-09-19 California Institute Of Technology Procedes et appareil d'analyse de sequences de polynucleotide par extension de base asynchrone
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
NZ527937A (en) 2001-03-13 2005-03-24 Novartis Ag Stable cell lines to express high levels of lentiviral Gag/Pol proteins for generation of HIV- or BIV- based lentiviral vectors
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
US6528309B2 (en) 2001-03-19 2003-03-04 The Regents Of The University Of California Vacuum-mediated desiccation protection of cells
ES2271306T5 (es) 2001-03-19 2013-10-16 President And Fellows Of Harvard College Evolución de una nueva función molecular
CA2342376C (fr) * 2001-03-20 2013-11-12 Marco Colonna Nouveau recepteur trem (recepteur activateur exprime dans les cellules myeloides) et ses utilisations
IL142118A0 (en) * 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
US20090081199A1 (en) * 2001-03-20 2009-03-26 Bioxell S.P.A. Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US8231878B2 (en) * 2001-03-20 2012-07-31 Cosmo Research & Development S.P.A. Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US6613534B2 (en) 2001-03-20 2003-09-02 Wake Forest University Health Sciences MAP-2 as a determinant of metastatic potential
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
IL157842A0 (en) 2001-03-22 2004-03-28 Novo Nordisk Healthcare Ag Coagulation factor vii derivatives
WO2002076189A1 (fr) * 2001-03-22 2002-10-03 Scentgene Pollination Ltd. Procede pour accroitre l'entomophilie
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6949340B2 (en) 2001-03-28 2005-09-27 Creative Mines Llc Optical phase modulator
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
JP3945993B2 (ja) * 2001-03-29 2007-07-18 富士通株式会社 半導体記憶装置
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
AU785425B2 (en) * 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US6596489B2 (en) 2001-03-30 2003-07-22 Applied Gene Technologies Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
US20020197243A1 (en) * 2001-03-30 2002-12-26 Nicolette Charles A. Novel p53BP2 compounds for therapy and diagnosis and methods for using same
PL367162A1 (en) 2001-04-02 2005-02-21 Wyeth Pd-1, a receptor for b7-4, and uses therefor
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
AU2002256053A1 (en) * 2001-04-04 2002-10-21 Genzyme Corporation Novel bgp compounds for therapy and diagnosis and methods for using same
US20040237128A1 (en) * 2001-04-04 2004-11-25 Nicole Beauchemin Transgenic non-human animal having a disruption of at least one allele to the ceacam 1 gene and method of making same
FR2823064B1 (fr) * 2001-04-04 2004-05-28 Biogemma Fr Procede d'obtention de plantes c4 a metabolisme carbone modifie
WO2002080845A2 (fr) * 2001-04-04 2002-10-17 Genzyme Corporation Nouveaux composes eps8 de traitement et de diagnostic, et methodes d'utilisation de ces composes
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7241935B2 (en) * 2001-04-13 2007-07-10 The Board Of Trustees Operating Michigan State University Compositions and methods for the production of betaine lipids
US7169597B2 (en) * 2001-04-13 2007-01-30 Michigan State University Compositions and methods for the production of betaine lipids
KR20080081201A (ko) 2001-04-16 2008-09-08 와이어쓰 홀딩스 코포레이션 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물
AUPR446701A0 (en) 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
CA2444195A1 (fr) * 2001-04-19 2002-10-31 Invitrogen Corporation Compositions et procedes destines au clonage recombinant de molecules d'acides nucleiques
BR0209095A (pt) * 2001-04-23 2004-07-13 Monsanto Technology Llc Monitoração baseada em pcr de sistemas de biotratamento de água residual
US20030224365A1 (en) * 2001-04-24 2003-12-04 Wood Linda Susan Single nucleotide polymorphisms diagnostic for schizophrenia
US6617136B2 (en) 2001-04-24 2003-09-09 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
WO2002088081A2 (fr) * 2001-05-01 2002-11-07 The Regents Of The University Of California Recepteurs wnt et frizzled utilises comme cibles en immunotherapie contre un carcinome spinocellulaire cervico-facial
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
US20030017159A1 (en) * 2001-05-02 2003-01-23 Jerome Ritz Immunogenic tumor antigens: nucleic acids and polypeptides encoding the same and methods of use thereof
EP1430125A4 (fr) * 2001-05-03 2005-01-19 Childrens Medical Center Canal cationique specifique du sperme, et utilisations correspondantes
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US7060441B2 (en) * 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
WO2002089844A1 (fr) 2001-05-07 2002-11-14 Mayo Foundation For Medical Education And Research Detection de legionella par transfert d'energie a resonance fluorescente
CA2446112C (fr) 2001-05-08 2011-04-26 Darwin Molecular Corporation Methode de regulation de la fonction immune chez les primates a l'aide de la proteine foxp3
US7244853B2 (en) * 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
EP1950305A1 (fr) 2001-05-09 2008-07-30 Monsanto Technology, LLC Gènes tyr et utilisations associées
WO2002090506A2 (fr) 2001-05-09 2002-11-14 Monsanto Technology Llc Transporteurs de metabolites
US20030152942A1 (en) * 2001-05-09 2003-08-14 Lance Fors Nucleic acid detection in pooled samples
EP1988097A1 (fr) 2001-05-09 2008-11-05 Corixa Corporation Compositions et procédés pour le traitement et le diagnostic du cancer de la prostate
DE60234523D1 (de) 2001-05-15 2010-01-07 Novozymes As Alpha-amylasevariante mit veränderten eigenschaften
CA2444960C (fr) 2001-05-18 2011-08-09 Danisco A/S Procede servant a ameliorer la qualite d'une pate et d'un pain
WO2002095002A2 (fr) 2001-05-22 2002-11-28 University Of Chicago Arn polymerase dependant de l'adn a brin unique de virion n4
EP1402009A4 (fr) * 2001-05-24 2005-02-02 Cephalon Inc Nouveau polypeptide de kinase 7 de lignee melangee (mlk7), polynucleotides les codant, et leurs methodes d'utilisation
UY27304A1 (es) * 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
US20030129607A1 (en) * 2001-05-25 2003-07-10 Invitrogen Corporation Compositions and methods for extension of nucleic acids
US20050003356A1 (en) * 2001-05-25 2005-01-06 Hayden Michael R. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
EP1402064A4 (fr) 2001-05-30 2005-08-24 Gene Therapy Systems Inc Reseaux de proteines et procedes et systemes pour les produire
CA2348042A1 (fr) 2001-06-04 2002-12-04 Ann Huletsky Sequences permettant de detecter et d'identifier des staphylococcus aureus resistant a la meticilline
MXPA03011194A (es) 2001-06-06 2004-02-26 Novozymes As Endo-beta-1,4-glucanasa.
US20020187490A1 (en) * 2001-06-07 2002-12-12 Michigan State University Microbial identification chip based on DNA-DNA hybridization
CA2449649A1 (fr) * 2001-06-07 2002-12-19 Wyeth Recepteur couple a une proteine g et utilisations
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6770622B2 (en) 2001-06-08 2004-08-03 Gary A. Jarvis N-terminally truncated galectin-3 for use in treating cancer
US7291490B2 (en) * 2001-06-11 2007-11-06 Ecopia Biosciences Inc. Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
CA2386587C (fr) 2001-06-11 2006-06-06 Ecopia Biosciences Inc. Genes et proteines pour la biosynthese de l'antramycine
US20030165895A1 (en) * 2001-06-12 2003-09-04 Bogdan Czerniak Methods of detecting, diagnosing and treating cancer and identifying neoplastic progression
EA006679B1 (ru) * 2001-06-12 2006-02-24 Такара Био Инк. Способ стабилизации реагента для амплификации или детекции нуклеиновой кислоты и способ хранения
ES2571835T3 (es) 2001-06-20 2016-05-27 Nuevolution As Moléculas y métodos con plantilla para el uso de tales moléculas
US7125664B2 (en) * 2001-06-20 2006-10-24 Dahlia Minc-Golomb Method for identifying genes that are upstream regulators of other genes of interest
US7491506B2 (en) * 2001-06-21 2009-02-17 The Regents Of The University Of California Inhibition of B-cell maturation and antibody production
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
EP2327985B2 (fr) 2001-06-26 2019-08-21 Senomyx, Inc. Récepteurs du goût hétéro-oligomériques T1R et lignées cellulaires qui expriment ces récepteurs et utilisation associée pour l'identification des composants du goût
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US20030096377A1 (en) * 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
DK1421175T3 (da) * 2001-06-28 2009-03-23 Mountain View Pharmaceuticals Polymerstabiliserede proteinaser
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
JP5033303B2 (ja) 2001-07-05 2012-09-26 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド 抗原性c型hivポリペプチドをコードするポリヌクレオチド、ポリペプチドおよびそれらの使用
US20030087274A1 (en) * 2001-07-05 2003-05-08 Anderson David W. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040029790A1 (en) * 2001-07-05 2004-02-12 Meera Patturajan Novel human proteins, polynucleotides encoding them and methods of using the same
CA2452119C (fr) 2001-07-05 2013-10-15 Chiron Corporation Polynucleotides codant pour des polypeptides antigeniques du vih de sous-type b et/ou de sous-type c, polypeptides et leurs utilisations
EP1417475A4 (fr) * 2001-07-06 2006-06-28 454 Corp Methode utilisant un filtre poreux pour isoler en parallele des micro-reactions chimiques independantes
US20030032172A1 (en) * 2001-07-06 2003-02-13 The Regents Of The University Of California Automated nucleic acid assay system
AU2002318229B2 (en) 2001-07-10 2008-03-13 Senomyx, Inc. Use of specific T2R taste receptors to identify compounds that block bitter taste
AU2002327236A1 (en) 2001-07-12 2003-01-29 Illumina, Inc. Multiplex nucleic acid reactions
US7226732B2 (en) 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
AU2002322515A1 (en) * 2001-07-17 2003-03-03 Keith Choate Compositions, methods, and kits related to treating and diagnosing hypertension
US6884619B2 (en) 2001-07-17 2005-04-26 Yale University Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
US20050022269A1 (en) * 2001-07-19 2005-01-27 Joseph Hirschberg Polypeptides having carotenoids isomerase catalytic activity, nucleic acids encoding same and uses thereof
US6632611B2 (en) 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
WO2003010516A1 (fr) * 2001-07-23 2003-02-06 Curagen Corporation Procede d'identification d'une sequence d'acide nucleique
US20040191769A1 (en) * 2001-07-24 2004-09-30 Transgenomic, Inc. Methods, compositions, and kits for mutation detection in mitochondrial DNA
US6872529B2 (en) * 2001-07-25 2005-03-29 Affymetrix, Inc. Complexity management of genomic DNA
ATE463581T1 (de) 2001-07-30 2010-04-15 Genencor Int Phosphatlimitierter induzierbarer promotor und bacillus-expressionssystem
EP1420821B8 (fr) 2001-07-31 2011-02-02 University of Washington Antigenes du virus de l'herpes simplex (hsv) importants d'un point de vue immunologiques et procedes d'utilisation correspondants
US8048644B1 (en) 2001-08-01 2011-11-01 The University Of North Carolina At Charlotte Biological indicator for monitoring the transport of micro-organisms in the environment
ATE481497T1 (de) * 2001-08-01 2010-10-15 Univ Utah Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
US6403341B1 (en) 2001-08-02 2002-06-11 Wayne M. Barnes Magnesium precipitate hot start method for PCR
US20040030096A1 (en) * 2001-08-02 2004-02-12 Linda Gorman Novel human proteins, polynucleotides encoding them and methods of using the same
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
DK1412493T3 (da) 2001-08-02 2012-01-09 Inst Clayton De La Rech Fremgangsmåder og sammensætninger der angår forbedrede lentiviral-vektor.-produktionsystemer
US20030027258A1 (en) * 2001-08-02 2003-02-06 Chang Fang-Tseh Frank Methods and compositions for pearl oyster cultivation
US20030027196A1 (en) * 2001-08-02 2003-02-06 Barnes Wayne M. Magnesium precipitate methods for magnesium dependent enzymes
US20040006033A1 (en) * 2001-08-06 2004-01-08 Zhu York Yuan-Yuan Methods for identifying low-abundance polynucleotides and related compositions
AU2002355562A1 (en) * 2001-08-08 2003-02-24 Curagen Corporation System and method for identifying a genetic risk factor for a disease or pathology
WO2003014703A2 (fr) * 2001-08-09 2003-02-20 Curagen Corporation Acides nucleiques, polypeptides, polymorphismes nucleotidiques simples et techniques d'utilisation de ceux-ci
US20040166491A1 (en) * 2001-08-09 2004-08-26 Henderson Lee A Vhl promoter diagnostic polymorphism
EP1428139B1 (fr) * 2001-08-14 2015-06-03 Microsoft Technology Licensing, LLC Systeme et procede d'extraction d'un contenu destine a etre soumis a un moteur de recherche
EP2354157B1 (fr) 2001-08-14 2013-10-23 Sentigen Biosciences, Inc. Acides nucléiques et protéines de gènes de récepteur odorant OR83B d'insectes et utilisations associées
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
US7442781B2 (en) 2001-08-16 2008-10-28 Urifer Ltd. Diagnosis, prevention and treatment of cancer
US20040242479A1 (en) * 2001-08-17 2004-12-02 Elisabeth Bock Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival of cells
US20080026367A9 (en) * 2001-08-17 2008-01-31 Perlegen Sciences, Inc. Methods for genomic analysis
KR20040028991A (ko) * 2001-08-20 2004-04-03 다카라 바이오 가부시키가이샤 핵산 증폭 방법
WO2003020980A2 (fr) * 2001-08-28 2003-03-13 Pharmacia & Upjohn Company Polymorphismes nucleotidiques simples permettant le diagnostic de la schizophrenie
US20040115699A1 (en) * 2001-08-28 2004-06-17 Kaytes Paul S. Single nucleotide polymorphisms diagnostic for schizophrenia
US6995841B2 (en) * 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
WO2006071776A2 (fr) 2004-12-23 2006-07-06 Ge Healthcare Bio-Sciences Corp. Amplification d'arn fondee sur la ligature
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
CA2356540A1 (fr) * 2001-08-30 2003-02-28 Emory University Sequences d'adn exprimees jouant un role dans les fonctions mitochondriales
US20050123913A1 (en) * 2001-08-30 2005-06-09 Emory University Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
DE10143106C1 (de) * 2001-09-03 2002-10-10 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
US20120077196A9 (en) * 2001-09-03 2012-03-29 Guido Krupp Universal method for selective amplification of mRNAs
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US6898531B2 (en) 2001-09-05 2005-05-24 Perlegen Sciences, Inc. Algorithms for selection of primer pairs
WO2003021259A1 (fr) * 2001-09-05 2003-03-13 Perlegen Sciences, Inc. Selection de paires d'amorces
US6740510B2 (en) 2001-09-05 2004-05-25 Perlegen Sciences, Inc. Methods for amplification of nucleic acids
WO2003023000A2 (fr) * 2001-09-07 2003-03-20 Baylor College Of Medicine Fragments d'adn lineaires destines a l'expression genetique
US20040136972A1 (en) 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US20040191774A1 (en) * 2001-09-11 2004-09-30 Moskowitz David W Endothelin-1 promoter polymorphism
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
EP1578914A2 (fr) * 2001-09-12 2005-09-28 Pharmacia & Upjohn Company LLC Canaux ionique humains
US20060068405A1 (en) * 2004-01-27 2006-03-30 Alex Diber Methods and systems for annotating biomolecular sequences
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
FR2829774B1 (fr) 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
US20070020622A1 (en) * 2001-09-14 2007-01-25 Invitrogen Corporation DNA Polymerases and mutants thereof
US20050042629A1 (en) * 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
US20060188875A1 (en) * 2001-09-18 2006-08-24 Perlegen Sciences, Inc. Human genomic polymorphisms
WO2005110493A2 (fr) * 2004-04-16 2005-11-24 Bioexpertise Llc Methodes de transfert d'un agent lie au peptide mbd dans des cellules dans des conditions de stress cellulaire
EP1908851A3 (fr) 2001-09-19 2008-06-25 Intergenetics Incorporated Analyse génétique pour la stratification du risque de cancer
US20040002071A1 (en) 2001-09-19 2004-01-01 Intergenetics, Inc. Genetic analysis for stratification of cancer risk
US7414111B2 (en) 2001-09-19 2008-08-19 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
JP4439262B2 (ja) 2001-09-19 2010-03-24 アレクシオン ファーマシューティカルズ, インコーポレイテッド 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用
EP1435977A4 (fr) * 2001-09-19 2005-06-08 Ford Henry Health System Transplantation cardiaque de cellules souches pour le traitement de l'insuffisance cardiaque
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
US7202028B2 (en) * 2001-09-24 2007-04-10 The University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
US6846631B2 (en) 2001-09-24 2005-01-25 Syngenta Participations Ag Detection of Fusarium species infecting corn using the polymerase chain reaction
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US6852492B2 (en) 2001-09-24 2005-02-08 Intel Corporation Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication
CN1312289C (zh) 2001-09-24 2007-04-25 一兰姆达公司 诊断探针检测系统
KR20040039444A (ko) 2001-09-27 2004-05-10 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인간 응고 인자 ⅶ 폴리펩티드
WO2003027243A2 (fr) 2001-09-27 2003-04-03 Pioneer Hi-Bred International, Inc. Polynucléotides de phytate et méthodes d'utilisation
US6902914B2 (en) * 2001-09-28 2005-06-07 Sigma-Aldrich, Co. Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US20040106109A1 (en) * 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
CN1606456A (zh) 2001-10-02 2005-04-13 克雷顿研究院 限制性表达慢病毒载体
US6787327B2 (en) 2001-10-05 2004-09-07 Kelk Graduate Of Applied Life Sciences Methods for determining tyrosine-DNA phosphodiesterase activity
GB0123856D0 (en) * 2001-10-05 2001-11-28 Amersham Pharm Biotech Uk Ltd Method for determining cell cycle position
US20040053232A1 (en) * 2001-10-05 2004-03-18 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
US20030199442A1 (en) * 2001-10-09 2003-10-23 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2003031591A2 (fr) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detection de cibles a l'aide de marqueurs uniques d'identification de nucleotides
EP2298354B1 (fr) 2001-10-10 2014-03-19 ratiopharm GmbH Remodelage et glycoconjugation de Intérferon-beta
MXPA04003333A (es) 2001-10-10 2006-02-22 Neose Technologies Inc Remodelado y glicoconjugacion de peptidos.
CA2463556A1 (fr) * 2001-10-11 2003-04-17 Marical, Inc. Procede de mise en place d'empreinte perceptive et de grossissement de poisson au moyen d'une substance odorante
JP2005522187A (ja) * 2001-10-12 2005-07-28 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ 胃腸化学感覚受容体
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US20040014067A1 (en) * 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US20030082563A1 (en) * 2001-10-15 2003-05-01 Bell Constance A. Detection of bacillus anthracis
CN1604790A (zh) * 2001-10-15 2005-04-06 希龙公司 通过施用组织因子途径抑制剂(tfpi)治疗严重性肺炎
MXPA04003514A (es) 2001-10-19 2004-07-23 Vascular Biogenics Ltd Construcciones de polinucleotidos, composiciones farmaceuticas y metodos para reducir la regulacion dirigida de angionesis y terapia anticancer.
US8729248B2 (en) 2001-10-22 2014-05-20 Children's Medical Center Corporation Sperm-specific cation channel, CATSPER2, and uses therefor
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US6942972B2 (en) 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
EP1436426A4 (fr) * 2001-10-24 2005-11-02 Singulex Inc Procedes destines a detecter des haplotypes genetiques par interaction avec des sondes
WO2003038111A2 (fr) 2001-10-26 2003-05-08 Genencor International, Inc. Enzymes phytases, sequences d'acides nucleiques codant les phytases, vecteurs et cellules hotes comprenant ces dernieres
WO2003038112A2 (fr) 2001-10-26 2003-05-08 Baylor College Of Medicine Composition et methode permettant de modifier la masse maigre et les proprietes osseuses d'un sujet
EP1444246B1 (fr) 2001-10-26 2015-12-30 Danisco US Inc. Enzymes phytase produites par trichoderma reesei, acides nucleiques codant les enzymes phytase, vecteurs et cellules hotes incorporant les enzymes phytase, et methodes de production et d'utilisation des enzymes phytase
WO2003038127A1 (fr) * 2001-10-30 2003-05-08 Ahram Biosystems Inc. Procede et appareil permettant d'amplifier des sequences d'acides nucleiques a l'aide d'une adn polymerase immobilisee
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20040038229A1 (en) * 2001-11-01 2004-02-26 Keating Christine Dolan Enzymatic manipulation of metal particle-bound DNA
US20030129709A1 (en) * 2001-11-02 2003-07-10 Olga Makarova Method for site-directed mutagenesis of nucleic acid molecules using a single primer
ES2264461T3 (es) * 2001-11-02 2007-01-01 Roche Diagnostics Gmbh Deteccion del virus de la viruela.
CA2466133A1 (fr) * 2001-11-02 2003-05-15 Rice University Systeme de recyclage permettant la manipulation de la disponibilite intracellulaire du nadh
US20030119000A1 (en) * 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
WO2003051174A2 (fr) * 2001-11-09 2003-06-26 Neurogenetics, Inc. Polymorphismes de nucleotide unique (snp) et ses mutations dans l'alpha-2-macroglobuline
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
CA2466346A1 (fr) * 2001-11-09 2003-05-22 Pharmacia & Upjohn Company Presence de polymorphismes a nucleotide unique dans une hormone de croissance gh-1
PT2308888T (pt) 2001-11-14 2017-05-03 Janssen Biotech Inc Anticorpos anti-il-6, composições, métodos e utilizações
US7222059B2 (en) * 2001-11-15 2007-05-22 Siemens Medical Solutions Diagnostics Electrophoretic trace simulator
US7166463B2 (en) * 2001-11-16 2007-01-23 The Regents Of The University Of Colorado Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
CA2467717A1 (fr) * 2001-11-19 2003-05-30 Interleukin Genetics, Inc. Polymorphismes fonctionnels du site de l'interleukine-1 affectant la transcription et la susceptibilite aux affections inflammatoires et infectieuses
US20080311581A1 (en) * 2001-11-19 2008-12-18 David Wyllie Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases
US6696254B2 (en) 2001-11-21 2004-02-24 Kimberly-Clark Worldwide, Inc. Detection and identification of enteric bacteria
EP1456398B1 (fr) 2001-11-21 2011-05-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recuperation d'un virus parainfluenza de type 1 humain (hpiv1) a partir d'un adn complementaire
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
EP1456220A4 (fr) 2001-11-30 2005-03-09 Applera Corp Polymerases d acides nucleiques provenant de thermus thermophilus
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
WO2003048308A2 (fr) 2001-11-30 2003-06-12 Applera Corporation Polymérases d'acide nucléique du thermus brockanius
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
US6635428B2 (en) 2001-12-04 2003-10-21 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis B viral nucleic acids
AU2002358947A1 (en) * 2001-12-05 2003-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof
US20060165683A1 (en) 2001-12-05 2006-07-27 Gerard Karsenty Methods and compositions for control of bone formation via modulation of sympathetic tone
WO2003050258A2 (fr) 2001-12-07 2003-06-19 Chiron Corporation Polypeptides de retrovirus endogenes lies a la transformation oncogenique
US20060275747A1 (en) * 2001-12-07 2006-12-07 Hardy Stephen F Endogenous retrovirus up-regulated in prostate cancer
US20030175749A1 (en) * 2001-12-08 2003-09-18 Jong-Yoon Chun Annealing control primer and its uses
ATE503845T1 (de) * 2001-12-10 2011-04-15 Novartis Pharma Gmbh Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen
MXPA04005713A (es) 2001-12-11 2005-06-06 Baylor College Medicine Complemento de la hormona de liberacion de la hormona de crecimiento para tratar sujetos cronicamente enfermos.
NZ546711A (en) 2001-12-12 2008-06-30 Chiron Srl Immunisation against chlamydia trachomatis
US20030148462A1 (en) * 2001-12-14 2003-08-07 President And Fellows Of Harvard College Dual inhibition of sister chromatid separation at metaphase
ES2405790T3 (es) 2001-12-17 2013-06-03 Corixa Corporation Composiciones y métodos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino
US20040126829A1 (en) * 2001-12-18 2004-07-01 Hildebrand William H. Anti-HLA assay and methods
ES2337989T3 (es) * 2001-12-18 2010-05-03 Endocube Sas Nuevas proteinas asociadas a la muerte de la familia thap y rutas par4 relacionadas implicadas en el control de la apoptosis.
KR100446621B1 (ko) * 2001-12-18 2004-09-07 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 mody3유전자의 증폭을 위한 프라이머 세트
US7858297B2 (en) * 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
WO2003054158A2 (fr) * 2001-12-19 2003-07-03 The University Of Chicago Proteines fluorescentes a maturation rapide et leurs methodes d'utilisation
US20030170691A1 (en) * 2001-12-19 2003-09-11 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor
DE60228995D1 (de) * 2001-12-19 2008-10-30 Affymetrix Inc Arrayplatten und verfahren zur herstellung von arrayplatten
US20030180741A1 (en) 2001-12-21 2003-09-25 Holly Hogrefe High fidelity DNA polymerase compositions and uses therefor
US20050085432A1 (en) * 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
EP1457556A4 (fr) * 2001-12-28 2005-01-19 Takeda Pharmaceutical Procede et kit de quantification d'acides nucleiques
AU2002364607A1 (en) * 2001-12-28 2003-07-24 The Burnham Institute Novel ligand involved in the transmigration of leukocytes .
US6578724B1 (en) * 2001-12-29 2003-06-17 United States Can Company Connector for use in packaging aerosol containers
US7135174B2 (en) * 2002-01-07 2006-11-14 Amgen Fremont, Inc. Antibodies directed to PDGFD and uses thereof
EP1462517A1 (fr) * 2002-01-08 2004-09-29 Japan Science and Technology Agency Procede de pcr par transport electrostatique, procede d'hybridation pour transport electrostatique et dispositifs prevus a cet effet
US7373968B2 (en) * 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
AU2003201741A1 (en) 2002-01-09 2003-07-24 Yusuke Nakamura Cancer profiles
US6900017B2 (en) * 2002-01-10 2005-05-31 The Board Of Trustees Of The University Of Illinois Human hematopoietic growth regulatory gene and uses
FR2834521B1 (fr) * 2002-01-10 2004-12-17 Bio Merieux Procede de detection et/ou d'identification de l'espece animale d'origine de la matiere animale contenue dans un echantillon
US20050158296A1 (en) 2002-01-11 2005-07-21 Starr Christopher M. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
US7125478B2 (en) * 2002-01-18 2006-10-24 The Regents Of The University Of Michigan Microscale electrophoresis devices for biomolecule separation and detection
PT2230299E (pt) 2002-01-18 2012-03-02 Zymogenetics Inc Novo ligando de citocina zcytor17
US7494804B2 (en) 2002-01-18 2009-02-24 Zymogenetics, Inc. Polynucleotide encoding cytokine receptor zcytor17 multimer
US20030232203A1 (en) * 2002-01-18 2003-12-18 The Regents Of The University Of Michigan Porous polymers: compositions and uses thereof
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1465982A4 (fr) 2002-01-25 2006-06-07 Gamida Cell Ltd Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
US20070264645A1 (en) * 2002-01-25 2007-11-15 Kenneth Kornman IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US20040116668A1 (en) * 2002-01-29 2004-06-17 Robert Day Zis-sr nucleic acid and amino acid sequences involved in the regulated secretory pathway and/or the regulation of the neuroendocrine phenotype (nep)
US20040096826A1 (en) * 2002-01-30 2004-05-20 Evans Glen A. Methods for creating recombination products between nucleotide sequences
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
JP2005515780A (ja) 2002-02-01 2005-06-02 セクイター インコーポレイテッド 二本鎖オリゴヌクレオチド
US20040053264A1 (en) * 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20040166492A1 (en) * 2002-02-05 2004-08-26 Engel Stacia R. Quantitative detection of dekkera and saccharomyces
AU2003216438B2 (en) * 2002-02-07 2008-05-01 E.I. Du Pont De Nemours And Company UDP-glucosyltransferases
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
AU2003213107A1 (en) 2002-02-15 2003-09-09 Exact Sciences Corporation Methods for analysis of molecular events
US7384734B2 (en) 2002-02-15 2008-06-10 Monogram Biosciences, Inc. Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors
US20030235533A1 (en) * 2002-02-19 2003-12-25 Idec Pharmaceuticals Corporation Prostate specific genes and the use thereof in design or therapeutics
US6593093B1 (en) * 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
US7354742B2 (en) 2002-02-22 2008-04-08 Ortho-Mcneil Pharmaceutical, Inc. Method for generating amplified RNA
US20050165558A1 (en) * 2002-02-26 2005-07-28 Becker Robert G. Sequence detection system calculator
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
CA2477761A1 (fr) * 2002-03-01 2003-09-12 Ravgen, Inc. Procedes de detection de troubles genetiques
EP2278509B1 (fr) 2002-03-01 2014-11-19 Codexis Mayflower Holdings, LLC Procédés, systèmes et logiciel pour identifier des biomolécules fonctionnelles
US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
US7179639B2 (en) * 2002-03-05 2007-02-20 Raveendran Pottathil Thermal strip thermocycler
CA2477780A1 (fr) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Procedes d'amelioration de l'induction de la reponse immunitaire impliquant mda-7
ES2253461T3 (es) * 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
GB0205455D0 (en) * 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
JP4851687B2 (ja) 2002-03-09 2012-01-11 マキシジェン, インコーポレイテッド 定向進化のための交叉点の最適化
DE60332781D1 (de) 2002-03-11 2010-07-08 Lab 21 Ltd Verfahren und Zusammensetzungen zur Identifizierung und Charakterisierung von Hepatitis C
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20030228596A1 (en) * 2002-03-14 2003-12-11 Qiang Liu Template-driven nucleic acid amplifications
HUP0200981A3 (en) * 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
CA2479679A1 (fr) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Procedes permettant d'induire la differenciation dans des cellules souches expansees ex vivo
EP2319935B1 (fr) 2002-03-19 2016-04-27 Stichting Dienst Landbouwkundig Onderzoek Expression de GnTIII (UDP-N-acétylglucosamine: Beta -D mannoside Beta (1,4)-N-acétylglucosaminyltransferase III) dans des plantes
JP2005520543A (ja) * 2002-03-21 2005-07-14 サイグレス ディスカバリー, インコーポレイテッド 癌における新規組成物および方法
US20040110208A1 (en) * 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
EP1578354A4 (fr) * 2002-03-26 2008-04-09 Massachusetts Inst Technology Cibles, procedes et reactifs pour le diagnostic et le traitement de la schizophrenie
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20030186246A1 (en) * 2002-03-28 2003-10-02 Willey James C. Multiplex standardized reverse transcriptase-polymerase chain reacton method for assessment of gene expression in small biological samples
DK2339016T3 (da) 2002-03-29 2017-01-23 Danisco Us Inc Øget produktion af subtilisiner
US7148049B2 (en) 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
EP2275128B1 (fr) 2002-04-02 2013-10-16 Ben Gurion University Of The Negev Research And Development Authority Vaccins contre le streptococcus pneumoniae à base de protéine
US7052840B2 (en) * 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US6849548B2 (en) * 2002-04-05 2005-02-01 Seh America, Inc. Method of reducing particulate contamination during polishing of a wafer
AU2002367869A1 (en) * 2002-04-08 2003-10-27 Transgenomic Inc. Methods and kits for testing mutagenicity
EP1497447A4 (fr) 2002-04-12 2006-09-20 Univ Missouri Microreseaux ecist con us pour effectuer un criblage double d'une hypermethylation de l'adn et d'une inactivation genique, et destines a etre utilises dans un systeme integre pour evaluer une expression genique, une methylation de l'adn et une acetylation d'histone
AU2003239129A1 (en) * 2002-04-12 2003-10-27 New England Biolabs, Inc. Methods and compositions for dna manipulation
ATE552849T1 (de) * 2002-04-12 2012-04-15 Medarex Inc Behandlungsverfahren unter verwendung von ctla-4 antikörpern
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
CA2482485A1 (fr) * 2002-04-15 2003-10-30 Merck & Co., Inc. Analyse matricielle d'expression genique dans des cellules
DE60335536D1 (de) 2002-04-19 2011-02-10 Bristol Myers Squibb Co Verfahren zum nachweis oder zur modulierung der wechselwirkung eines cytokinrezeptors mit seinem ligand
BR0309391A (pt) 2002-04-19 2005-10-25 Diversa Corp Fosfolipases, ácidos nucléicos codificando-as e métodos para preparar e usá-las
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US20080076678A1 (en) 2005-06-15 2008-03-27 Philippe Soucaille Method of creating a library of bacterial clones with varying levels of gene expression
US20030199038A1 (en) 2002-04-22 2003-10-23 Novozymes Biotech, Inc. Method for preparing polypeptide variants
JP2005523015A (ja) * 2002-04-22 2005-08-04 ジェネンコー・インターナショナル・インク 種々の遺伝子発現レベルを有する細菌クローンのライブラリーを構築する方法。
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
ATE424464T1 (de) * 2002-04-26 2009-03-15 Inst Nat Sante Rech Med Verbesserte chimäre glykoproteine und pseudotypisierte lentivirale vektoren
WO2003090605A2 (fr) 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Methode et systeme permettant de detecter des facteurs de risque cardiaque
US20040023275A1 (en) * 2002-04-29 2004-02-05 Perlegen Sciences, Inc. Methods for genomic analysis
DE60332556D1 (de) * 2002-05-01 2010-06-24 Danisco Us Inc Cytokine und cytokinrezeptoren mit reduzierter immunogenität
AU2003228751A1 (en) 2002-05-01 2003-11-17 Cell Genesys, Inc. Lentiviral vector particles resistant to complement inactivation
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
EP2216405A1 (fr) 2002-05-03 2010-08-11 Monsanto Technology LLC Promoteurs USP spécifiques de sémences pour l'expression de gènes dans des plantes
US20040121442A1 (en) * 2002-05-05 2004-06-24 Ilan Chet Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof
WO2003094841A2 (fr) * 2002-05-06 2003-11-20 Functional Genetics, Inc. Genes de mammifere impliques dans une resistance a la rapamycine et une genese tumorale : genes d'annexine xiii
AU2003239368A1 (en) 2002-05-06 2003-11-17 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
US7579147B2 (en) 2002-05-07 2009-08-25 Wake Forest University Health Sciences Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7825227B2 (en) * 2002-05-09 2010-11-02 Prolexys Pharmaceuticals, Inc. Method for purification of a protein complex and identification of its components
IL149562A0 (en) * 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US20030210489A1 (en) * 2002-05-13 2003-11-13 Yec Co., Ltd. Data eraser and data erasing program
ATE473281T1 (de) 2002-05-15 2010-07-15 Monsanto Technology Llc Verfahren zur erhöhung des samengewichtes in einer pflanze
BRPI0310060B8 (pt) 2002-05-17 2021-07-27 Becton Dickinson Co sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína
EP1504098B2 (fr) * 2002-05-17 2011-02-09 Alligator Bioscience AB Methode de developpement moleculaire in vitro d'une fonction de proteine
US20030215814A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Detection of Shiga toxin- or Shiga-like toxin-producing organisms
WO2003098278A2 (fr) * 2002-05-17 2003-11-27 Applera Corporation Appareil et procede pour differencier par longueur d'onde d'excitation des signaux de fluorescence multiples
US20030215816A1 (en) * 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
EP1365034A3 (fr) 2002-05-21 2004-02-18 Bayer HealthCare AG Procédés et compositions pour la prédiction, le diagnostic, le pronostic, la prévention et le traitement de neoplasie maligne
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US20040072208A1 (en) * 2002-05-23 2004-04-15 Peter Warthoe Surface acoustic wave sensors and method for detecting target analytes
WO2003100019A2 (fr) * 2002-05-24 2003-12-04 Invitrogen Corporation Pcr nichee par amorces degradables
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
US20030219755A1 (en) * 2002-05-24 2003-11-27 Nanibhushan Dattagupta Compositions and methods for performing hybridization assays using target enhanced signal amplification (TESA)
US7291460B2 (en) * 2002-05-31 2007-11-06 Verenium Corporation Multiplexed systems for nucleic acid sequencing
DE10224200C1 (de) * 2002-05-31 2003-08-21 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
EP1531676B1 (fr) 2002-06-05 2015-07-22 Genentech, Inc. Compositions et methodes de croissance et de protection du foie
US20060172294A1 (en) * 2002-06-06 2006-08-03 Arturas Petronis Detection of epigenetic abnormalities and diagnostic method based thereon
US20040033602A1 (en) * 2002-06-12 2004-02-19 Ambion, Inc. Methods and compositions relating to polypeptides with RNase III domains that mediate RNA interference
AU2003231912A1 (en) * 2002-06-12 2003-12-31 Tel Aviv Medical Center Research Development Fund Methods of detecting and treating prostate cancer
US20100075423A1 (en) * 2002-06-12 2010-03-25 Life Technologies Corporation Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
JP2005535308A (ja) * 2002-06-13 2005-11-24 カイロン コーポレイション Hml−2ポリペプチド発現用ベクター
WO2003106652A2 (fr) * 2002-06-14 2003-12-24 Cedars-Sinai Medical Center Methode d'analyse genetique basee sur l'haplotype, permettant de determiner le risque de developper une resistance a l'insuline, une maladie coronarienne et d'autres phenotypes
DE60335639D1 (de) * 2002-06-14 2011-02-17 Amylin Pharmaceuticals Inc Prävention und/oder behandlung von colitis ulcerosa mit pyy oder pyyä3-36ü
CA2488916C (fr) 2002-06-14 2016-08-09 Brian Steer Xylanases, acides nucleiques les codant et leurs procedes de fabrication et d'utilisation
US7585501B2 (en) 2002-06-14 2009-09-08 Stowers Institute For Medical Research Compositions and methods for treating kidney disease
US8178294B2 (en) * 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
AU2003247582A1 (en) * 2002-06-20 2004-01-06 Board Of Trustees Operating Michigan State University Plastid division and related genes and proteins, and methods of use
CN1668923A (zh) * 2002-06-24 2005-09-14 佳能株式会社 带有标准探针的dna微阵列以及包含该阵列的试剂盒
AU2003239087A1 (en) 2002-06-25 2004-01-06 Index Pharmaceuticals Ab Method and kit for the diagnosis of ulcerative colitis
ES2311731T3 (es) 2002-06-28 2009-02-16 Dow Agrosciences Llc Proteinas de accion pesticida y polinucleotidos que se pueden obtener a partir de especies de paenibacillus.
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
JP4617403B2 (ja) 2002-06-28 2011-01-26 プリメラディーエックス インコーポレイテッド 配列の相違を検出する方法
CA2490280A1 (fr) * 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Anticorps qui se lient specifiquement a reg iv
CN1678755A (zh) * 2002-07-01 2005-10-05 瓦罗洛吉克公司 确定致病性病毒对蛋白酶抑制剂易感性的组合物和方法
JP4013671B2 (ja) * 2002-07-05 2007-11-28 松下電器産業株式会社 ポリメラーゼ連鎖反応容器及びその製造方法
US20040009482A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae surface immunogenic protein genes
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
KR100442832B1 (ko) * 2002-07-10 2004-08-02 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 mody2 유전자의증폭을 위한 프라이머 세트
EP1534345A4 (fr) * 2002-07-12 2012-03-21 Yissum Res Dev Co Methode et dispositif d'induction de processus biologiques par des micro-organismes
CA2501188C (fr) 2002-07-15 2012-05-15 Board Of Regents, The University Of Texas System Criblage combinatoire de banques de proteines par expression periplasmique
US20040204953A1 (en) * 2002-07-17 2004-10-14 Lincoln Muir Subscription based systems, methods and components for providing genomic and proteomic products and services
WO2004006861A2 (fr) * 2002-07-17 2004-01-22 Mindset Biopharmaceuticals Usa Inc. Peptides et procedes de criblage de vaccins a base de peptides immunogenes contre la maladie d'alzheimer
CN101508996B (zh) 2002-07-18 2012-01-11 孟山都技术有限公司 利用人工的多核苷酸及其组合物来减少转基因沉默的方法
ATE494907T1 (de) 2002-07-18 2011-01-15 Univ Washington Pharmazeutische zusammensetzungen, die immunologisch aktive herpes simplex virus proteinfragmente enthalten
AU2003254128A1 (en) * 2002-07-19 2004-02-09 Arizona Board Of Regents A high resolution typing system for pathogenic mycobacterium tuberculosum
WO2004009619A2 (fr) * 2002-07-19 2004-01-29 Cellzome Ag Complexes proteiques de la proteine activatrice de la transcription de tip60
ATE506450T1 (de) 2002-07-23 2011-05-15 Biogenerix Ag Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen
EP1572959B1 (fr) 2002-07-25 2010-11-03 Bio-Rad Laboratories, Inc. Procedes de production de polymerases hybrides et compositions
US7057087B2 (en) * 2002-07-26 2006-06-06 Board Of Control Of Michigan Technological University Application of aspen MADS-box genes to alter reproduction and development in trees
US20040018497A1 (en) * 2002-07-26 2004-01-29 Warden Craig H Human obesity LIPIN3 polynucleotide and polypeptide sequences and methods of use thereof
US6933377B2 (en) * 2002-07-29 2005-08-23 Qun Chen Compositions comprising multiple immunodeficiency virus subunits for inducing an immune response
EP2385137A1 (fr) 2002-07-31 2011-11-09 University of Southern California Polymorphismes pour prédire les maladies les résultats de traitements
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
JP4595067B2 (ja) 2002-08-01 2010-12-08 エックスワイ,エルエルシー 低圧精子細胞分離システム
EP1524989B1 (fr) 2002-08-01 2013-11-06 Yeda Research And Development Co., Ltd. Methode et composition pour la protection du tissu neuronal contre une lesion induite par des taux de glutamate eleves
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
EP1572121B1 (fr) 2002-08-01 2012-01-11 The Regents of The University of California Anticorps monoclonaux therapeutiques qui neutralisent les neurotoxines botuliques
US20040078852A1 (en) * 2002-08-02 2004-04-22 Thomashow Michael F. Transcription factors to improve plant stress tolerance
AU2003254298A1 (en) * 2002-08-02 2004-02-23 Stratatech Corporation Species specific dna detection
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20080274989A1 (en) * 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20040241854A1 (en) * 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20050123924A1 (en) 2002-08-05 2005-06-09 Ayoub Rashtchian Compositions for in vitro amplification of nucleic acids
EP1576151A4 (fr) 2002-08-06 2006-05-17 Verdia Inc Variants de l'amine oxydase ap1
US20060123497A1 (en) * 2002-08-07 2006-06-08 Children's Medical Center Corporation Sperm-specific cation channel, catsper-4, and uses therefor
WO2004015067A2 (fr) 2002-08-07 2004-02-19 Children's Medical Center Corporation Canal cationique specifique du sperme, catsper-3, et utilisations correspondantes
RU2327487C2 (ru) 2002-08-08 2008-06-27 Бейлор Колледж Оф Медисин Выделение и идентификация т-клеток
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
KR20120002613A (ko) 2002-08-12 2012-01-06 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
AU2003250810A1 (en) * 2002-08-15 2004-03-03 Leuketoch A/S Bactericidal, anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp) or human neutrophil elastase
AU2003265525A1 (en) * 2002-08-15 2004-03-19 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
WO2004017041A2 (fr) 2002-08-15 2004-02-26 Xy, Inc. Cytometre de flux a haute resolution
WO2004020582A2 (fr) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Genes mammiferes impliques dans la resistance a la rapamycine et la tumorigenese designes sous le nom de genes rapr6
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
AU2003263937B2 (en) * 2002-08-19 2010-04-01 The President And Fellows Of Harvard College Evolving new molecular function
NZ542784A (en) 2002-08-19 2008-07-31 Astrazeneca Ab Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
ATE519862T1 (de) 2002-08-20 2011-08-15 Millennium Pharm Inc Zusammensetzungen, kits und verfahren zur identifizierung, beurteilung, vorbeugung und therapie von gebärmutterhalskrebs
AU2002950977A0 (en) * 2002-08-22 2002-09-12 Genetype Pty Ltd High resolution analysis of genetic variation within cryptosporidium parvum
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US20060099651A1 (en) * 2002-08-27 2006-05-11 Nobuko Uchida Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US9394332B2 (en) 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
DE60329853D1 (de) 2002-09-03 2009-12-10 Quanta Biosciences Inc Verbesserte zusammensetzungen und verfahren für die cdna-synthese
DE10240868A1 (de) * 2002-09-04 2004-03-18 Artus Gesellschaft für molekularbiologische Diagnostik und Entwicklung mbH Verbesserte Verfahren zur Synthese von Nukleinsäuren
WO2004022770A2 (fr) * 2002-09-05 2004-03-18 Invitrogen Corporation Compositions et procedes de synthese d'acides nucleiques
US20040109853A1 (en) * 2002-09-09 2004-06-10 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
EP1554377B1 (fr) 2002-09-13 2012-11-07 Life Technologies Corporation Transcriptases inverses thermostables et leurs utilisations
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
AU2002951411A0 (en) * 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
JP4549188B2 (ja) 2002-09-18 2010-09-22 アメリカ合衆国 組換えヒト2型パラインフルエンザウイルス(HPIV2)のcDNAからの回収(recovery)、並びにPIVおよび他のヒト病原体に対する免疫応答を誘発する免疫原性組成物における、そしてベクターとしての組換えHPIV2の使用
AU2003275065A1 (en) * 2002-09-20 2004-04-08 Wayne State University Molecular targets of cancer and aging
WO2004026804A1 (fr) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Colorants extincteurs de fluorescence a base d'anthraquinone et procedes de fabrication et d'utilisation
US7662594B2 (en) * 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
WO2004038037A2 (fr) * 2002-09-20 2004-05-06 Intel Corporation Alignement oriente de codes a barre nanometriques codant une information specifique pour la lecture par microscopie electronique a balayage (spm)
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
CA2498764C (fr) * 2002-09-20 2015-11-10 New England Biolabs, Inc. Amplification dependant de l'helicase des acides nucleiques
EP1546170A4 (fr) * 2002-09-20 2007-08-29 Univ Yale Riboswitchs, procedes d'utilisation et compositions a utiliser avec des riboswitchs
JP2006516884A (ja) 2002-09-23 2006-07-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー リアノジン受容体の単離および使用
EP1403379A1 (fr) * 2002-09-24 2004-03-31 QIAGEN GmbH Coamplification améliorée d'acides nucléiques
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) * 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) * 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US20050009051A1 (en) * 2002-09-27 2005-01-13 Board Of Regents, The University Of Texas Diagnosis of mould infection
WO2004028478A2 (fr) * 2002-09-27 2004-04-08 Medimmune Vaccines, Inc. Mutations fonctionnelles du virus respiratoire syncytial
US7534872B2 (en) * 2002-09-27 2009-05-19 Syngen, Inc. Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis
US7094879B2 (en) 2002-10-02 2006-08-22 Abbott Laboratories Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof
AU2003282667A1 (en) * 2002-10-03 2004-04-23 Large Scale Biology Corporation Multimeric protein engineering
JP2006501846A (ja) * 2002-10-04 2006-01-19 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ローソニア・イントラセルラリス由来の核酸およびポリペプチド配列ならびに使用方法
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
DK1546304T3 (da) * 2002-10-04 2013-08-05 Danisco Us Inc Forbedret produktion af bakteriestammer
US7267981B2 (en) 2002-10-07 2007-09-11 Technion Research & Development Foundation Ltd. Human foreskin fibroblasts for culturing ES cells
WO2005000194A2 (fr) 2002-10-08 2005-01-06 Rinat Neuroscience Corp. Procedes permettant de traiter des douleurs post-chirurgicales par administration d'un anticorps dirige contre le facteur de croissance neuronal, et compositions contenant cet anticorps
AU2003285864C1 (en) * 2002-10-08 2010-07-01 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering a nerve growth factor antagonist and compositions containing the same
UA80447C2 (en) * 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
EP1633786A4 (fr) * 2002-10-09 2007-07-25 Rinat Neuroscience Corp Methodes de traitement de la maladie d'alzheimer au moyen d'anticorps diriges contre le peptide g(b)-amyloide et compositions les comprenant
AU2003273640A1 (en) * 2002-10-10 2004-05-04 K.U. Leuven Research And Development Autism gene
US7606403B2 (en) * 2002-10-17 2009-10-20 Intel Corporation Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
WO2004037204A2 (fr) * 2002-10-25 2004-05-06 University Of South Florida Methodes et composes de perturbation de la signalisation cd40r/cd40l dans le traitement de la maladie d'alzheimer
AU2003287237A1 (en) 2002-10-28 2004-05-25 Xeotron Corporation Array oligomer synthesis and use.
US7595177B2 (en) 2002-10-29 2009-09-29 Advanta Canada, Inc. Assay for imidazolinone resistance mutations in Brassica species
US7803579B2 (en) * 2002-10-29 2010-09-28 Riken Process for amplifying nucleic acid
WO2004040252A2 (fr) 2002-10-30 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Molecules et leurs procedes d'utilisation pour la mesure de fer non lie par la transferrine
US20050037369A1 (en) * 2002-10-31 2005-02-17 Neote Kuldeep Singh Panels of molecular targets differentially expressed during CD8+ T cell priming, and methods for therapy and diagnosis utilizing the same
ATE428437T1 (de) * 2002-11-05 2009-05-15 Pasteur Institut Dc-sign blockern und deren verwendung zur vorbeugung oder behandlung von viraleninfektionen
US7427469B2 (en) * 2002-11-05 2008-09-23 Institut Pasteur Method of treating cytomegalovirus with DC-SIGN blockers
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
AU2003287622A1 (en) * 2002-11-06 2004-06-03 Fraunhofer Usa Expression of foreign sequences in plants using trans-activation system
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
US7258999B2 (en) * 2002-11-12 2007-08-21 Wyeth PTH responsive gene
KR100858080B1 (ko) * 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 pcr 증폭 산물을 검출하는 방법
US20060257871A1 (en) * 2002-11-12 2006-11-16 Franck Chaubron One step real-time rt pcr kits for the universal detection of organisms in industrial products
US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
EP1562982B1 (fr) 2002-11-15 2010-05-05 Novartis Vaccines and Diagnostics S.r.l. Proteines de surface inattendues du neisseria meningitidis
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
FR2847263B1 (fr) 2002-11-18 2006-01-13 Commissariat Energie Atomique Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans
US20040166514A1 (en) * 2002-11-19 2004-08-26 Singulex, Inc. Detection of target molecules through interaction with probes
AU2003293013A1 (en) * 2002-11-21 2004-06-18 University Of Massachusets Diagnosing and treating hematopoietic cancers
EP1563069B1 (fr) * 2002-11-22 2012-06-06 Institut Clayton De La Recherche Compositions et systemes destines a la regulation genique
JP2006510357A (ja) * 2002-11-22 2006-03-30 ザ ジョーンズ ホプキンズ ユニバーシティ 認識障害の処置のための標的
EP2581383A1 (fr) 2002-11-25 2013-04-17 Genencor International, Inc. Peptides se liant à la peau ou aux cheveux
EP2112229A3 (fr) 2002-11-25 2009-12-02 Sequenom, Inc. Procédés d'identification du risque du cancer du sein et traitements associés
PL377763A1 (pl) * 2002-11-25 2006-02-20 Attenuon, Llc. Peptydy, które hamują angiogenezę, migrację komórek, naciekanie komórkowe i proliferację komórkową oraz kompozycje zawierające te peptydy i ich zastosowania
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7829694B2 (en) * 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7605249B2 (en) * 2002-11-26 2009-10-20 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US7682688B2 (en) * 2002-11-26 2010-03-23 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
AU2003298733B2 (en) * 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
WO2004050826A2 (fr) * 2002-11-29 2004-06-17 Technion Research & Development Foundation Ltd. Procede de mise en culture dynamique de cellules souches embryonnaires
US20040248085A1 (en) * 2002-11-29 2004-12-09 Sang-Wha Lee General primers and process for detecting diverse genotypes of human papillomavirus by PCR
CA2506217A1 (fr) * 2002-12-03 2004-07-01 Robert Van Der Geize Nouveau systeme d'expression issu de <i>rhodococcus</i>
EP2194147B1 (fr) 2002-12-04 2015-07-22 Applied Biosystems, LLC Amplification multiplexe de polynucléotides
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
CA2508726A1 (fr) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Procedes d'identification rapide de pathogenes chez l'homme et les betes
EP1589807B1 (fr) 2002-12-06 2011-11-02 Del Monte Fresh Produce Company Plants d'ananas transgéniques présentant des teneurs modifiées en caroténoïdes et procédé de fabrication
CA2507240C (fr) 2002-12-06 2011-05-24 F. Hoffmann-La Roche Ag Detection par essais multiplex d'organismes pathogenes
AU2003298873B2 (en) 2002-12-06 2011-09-01 Millennium Pharmaceuticals, Inc. Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy
US7491699B2 (en) * 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
CN1230531C (zh) * 2002-12-09 2005-12-07 清华大学 从样品中分离细胞粒子的方法
CN1223680C (zh) * 2002-12-10 2005-10-19 清华大学 扩增靶细胞或病毒的核酸的方法
JP4185763B2 (ja) * 2002-12-12 2008-11-26 富士フイルム株式会社 ターゲット核酸の定量方法
SI2338896T1 (sl) 2002-12-12 2015-08-31 R.B.T. (Rakuto Bio Technologies) Ltd. Uporaba lignin peroksidaze za posvetlitev kože in las
US20050026168A1 (en) 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
WO2004055205A2 (fr) * 2002-12-13 2004-07-01 Infectio Diagnostic (I.D.I.) Inc. Reactifs biologiques et procedes permettant de verifier l'efficacite de la preparation d'un echantillon et de l'amplification et/ou de la detection d'un acide nucleique
CN100549163C (zh) 2002-12-16 2009-10-14 技术研究及发展基金有限公司 制备无饲养细胞、无异源的人胚胎干细胞的方法以及使用该方法制备的干细胞培养物
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
US8206904B2 (en) * 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
AU2003299441A1 (en) * 2002-12-19 2004-07-14 Centre National De La Recherche Scientifique - Cnrs Nf-hev compositions and methods of use
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
EP1572714A4 (fr) 2002-12-20 2006-08-09 Univ Texas Sequences d'especes et de souches de i borrelia /i pathogene de type vmp
EP2474631B1 (fr) 2002-12-20 2014-02-12 Celera Corporation Polymorphismes génétiques associés à l'infarctus du myocarde, procédés de détection et utilisations associées
EP1608952B1 (fr) 2002-12-20 2016-08-10 Life Technologies Corporation Appareil et procede de dosage utilisant des reseaux microfluidiques
NZ587852A (en) 2002-12-24 2012-02-24 Rinat Neuroscience Corp Anti-NGF antibodies and methods using same
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
WO2004060145A2 (fr) * 2002-12-31 2004-07-22 Baylor College Of Medicine Isolement et identification de lymphocytes t a reactivite croisee
AU2003288700B2 (en) 2003-01-02 2009-11-19 Rappaport Family Institute For Research In The Medical Sciences Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
ES2639812T3 (es) 2003-01-06 2017-10-30 Corixa Corporation Ciertos compuestos de fosfato de aminoalquil glucosaminida y sus usos
ATE426575T1 (de) * 2003-01-07 2009-04-15 Univ Ramot Peptidenanostrukturen die fremdmaterial enthalten,und verfahren zur herstellung derselben
CA2514450C (fr) 2003-01-31 2013-10-29 Monsanto Technology Llc Evenements transgeniques de la luzerne tolerant aux glycophosphates et methodes de detection
US20040224330A1 (en) * 2003-01-15 2004-11-11 Liyan He Nucleic acid indexing
MXPA05007653A (es) * 2003-01-17 2005-09-30 Danisco Metodo.
EP1590482B1 (fr) * 2003-01-17 2008-12-10 Eragen Biosciences, Inc. Amplification d'acides nucleiques au moyen de bases non standard
US7955814B2 (en) * 2003-01-17 2011-06-07 Danisco A/S Method
US20050196766A1 (en) * 2003-12-24 2005-09-08 Soe Jorn B. Proteins
DK2287317T3 (en) 2003-01-17 2015-01-05 Dupont Nutrition Biosci Aps A process for preparing a protein ester or an ester of a protein subunit
US8426194B2 (en) 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
US9068234B2 (en) 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
WO2004083806A2 (fr) 2003-01-22 2004-09-30 University Of South Florida Appareil a genocapteur autonome et procedes d'utilisation de celui-ci
JP5686493B2 (ja) 2003-01-24 2015-03-18 ユニバーシティ・オブ・ユタUniversity Of Utah テロメアの長さを決定することによって死亡の危険性を予測する方法
US7537765B2 (en) * 2003-01-29 2009-05-26 Panacos Pharmaceuticals, Inc. Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
ES2294462T5 (es) * 2003-01-29 2015-05-06 Epigenomics Ag Método mejorado para el tratamiento de bisulfito
CA2513541A1 (fr) * 2003-01-29 2004-08-19 454 Corporation Prodece de preparation de banques d'adn simple brin
EP1594435A4 (fr) * 2003-01-29 2006-12-27 Panacos Pharmaceuticals Inc Inhibition de la replication du vih-1 par interruption du traitement de la proteine capside-peptide espaceur 1 virale
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1613263A4 (fr) * 2003-01-31 2007-11-28 Pathologica Llc Suivi et de traitement de la sclerose laterale amyotrophique
ES2531125T3 (es) 2003-02-03 2015-03-10 Ibio Inc Sistema para la expresión de genes en plantas
US7994149B2 (en) 2003-02-03 2011-08-09 Medtronic, Inc. Method for treatment of Huntington's disease through intracranial delivery of sirna
EP1590440A4 (fr) * 2003-02-03 2009-03-18 Palo Alto Inst Of Molecular Me Molecules d'elimination de cellules et methodes d'utilisation associees
US7732591B2 (en) * 2003-11-25 2010-06-08 Medtronic, Inc. Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
WO2004070056A2 (fr) 2003-02-07 2004-08-19 Diagnocure Inc. Procede de detection de cancer de la prostate dans un echantillon
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
CA2457607A1 (fr) * 2003-02-12 2004-08-12 Agroterra Biotech Inc. Methode pour declencher une reaction en chaine de mutations
AU2004211592B2 (en) 2003-02-12 2008-04-10 Monsanto Technology Llc Cotton event MON 88913 and compositions and methods for detection thereof
TW200418829A (en) * 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
EP1638587A4 (fr) 2003-02-14 2007-04-18 Univ Missouri Methodes et compositions contraceptives associees aux interferences des proteasomes
EP1592708A2 (fr) 2003-02-14 2005-11-09 Sagres Discovery, Inc. Cibles therapeutiques du recepteur de couplage a la proteine g dans le cancer
US7824709B2 (en) 2003-02-14 2010-11-02 Children's Hospital And Research Center At Oakland Lipophilic drug delivery vehicle and methods of use thereof
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
US7312202B2 (en) 2003-02-18 2007-12-25 Board Of Regents, The University Of Texas System Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
KR20050111598A (ko) * 2003-02-19 2005-11-25 리나트 뉴로사이언스 코퍼레이션 신경 성장 인자 길항제 및 nsaid를 투여함으로써통증을 치료하는 방법 및 그것을 함유하는 조성물
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US20070025974A1 (en) * 2003-02-26 2007-02-01 Hardings Fiona A Amylases producing an altered immunogenic response and methods of making and using the same
EP2500423B1 (fr) 2003-02-26 2015-06-17 Danisco US Inc. Amylases produisant une réponse immunogène altérée et leurs procédés de fabrication et d'utilisation
WO2005014626A2 (fr) 2003-02-28 2005-02-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metapneumovirus humain recombinant et utilisation associee
EP1603943A2 (fr) * 2003-03-03 2005-12-14 Board of Regents, The University of Texas System Procedes et compositions impliquant mda-7
EP2319857A3 (fr) 2003-03-04 2012-06-27 Yeda Research And Development Co., Ltd. Polypeptides pon, polynucleotides les codant et compositions et procédés utilisant ces derniers
US7250296B2 (en) * 2003-03-05 2007-07-31 University Of Florida Research Foundation, Inc. Nucleotide sequences of 2S albumin gene and its promoter from grape and uses thereof
EP3023498B1 (fr) 2003-03-06 2018-11-28 BASF Enzymes LLC Amylases, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation
US20040175704A1 (en) * 2003-03-06 2004-09-09 Stratagene Compositions and methods for polynucleotide sequence detection
US20040235019A1 (en) * 2003-03-06 2004-11-25 Agouron Pharmaceuticals, Inc. Diagnostics and therapeutics for the gene expression signature of PPAR-gamma receptor ligand
BRPI0408157B8 (pt) 2003-03-07 2021-05-25 Dsm Food Specialties B V ácido nucléico recombinante, polipeptídeo recombinante com atividade lipase, célula transformada, métodos empregando os mesmos e composição
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
EP2374900B1 (fr) 2003-03-07 2016-07-13 Rubicon Genomics, Inc. Polynucleotides pour l'amplification et l'analyse de bibliotheques de genomes entiers et transcriptomes entiers generees par une methode d'amplification d'adn
WO2004081040A2 (fr) 2003-03-12 2004-09-23 Advisys, Inc. Suplementation d'igf-i avec mediation par plasmide pour applications therapeutiques
US8017113B2 (en) 2003-03-12 2011-09-13 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
CA2519092C (fr) 2003-03-14 2014-08-05 Neose Technologies, Inc. Polymeres hydrosolubles ramifies et conjugues de ceux-ci
AU2004221394A1 (en) * 2003-03-17 2004-09-30 The Johns Hopkins University Aberrantly methylated genes in pancreatic cancer
EP2390352A1 (fr) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systemes et procedes pour accroitre la production de proteines et de lait chez des bovins laitiers
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
WO2004084823A2 (fr) 2003-03-19 2004-10-07 Abgenix, Inc. Anticorps contre l'antigene de lymphocytes t, du domaine d'immunoglobuline et du domaine 1 de mucine (tim-1) et leurs utilisations
US20040185454A1 (en) * 2003-03-21 2004-09-23 Jones Alison M. Identification and quantification of microbial species in a sample
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
WO2004085670A2 (fr) * 2003-03-24 2004-10-07 Perkinelmer Las, Inc. Detection de polarisation
DE602004025801D1 (de) 2003-03-25 2010-04-15 Stratagene California Dna-polymerasefusionen und deren verwendungen
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
DK1608963T3 (da) 2003-03-28 2010-04-06 Inguran Llc Apparatur og fremgangsmåder til tilvejebringelse af kønssorteret dyresperma
US7067298B2 (en) * 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
CA2521127C (fr) * 2003-04-01 2014-05-27 Eragen Biosciences, Inc. Inhibiteur de polymerase et son procede d'utilisation
CN100497382C (zh) 2003-04-02 2009-06-10 得克萨斯州大学系统董事会 突变型Bik的抗肿瘤效果
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
DE10315640A1 (de) * 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
ES2369498T3 (es) 2003-04-04 2011-12-01 Yeda Research And Development Co., Ltd. Anticuerpos para inhibir la actividad de mmp-2 y mmp-9.
ES2545639T3 (es) 2003-04-04 2015-09-14 Basf Enzymes Llc Pectato liasas, ácidos nucleicos que las codifican y métodos para su preparación y uso
CA2520023C (fr) 2003-04-08 2013-02-05 Yeda Research And Development Co. Ltd Cellules souches presentant une sensibilite accrue a un chimioattracteur, et leurs procedes d'obtention et d'utilisation
WO2004092331A2 (fr) * 2003-04-08 2004-10-28 Li-Cor, Inc. Composition et procede pour le sequençage d'acides nucleiques
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US20050233390A1 (en) * 2003-04-09 2005-10-20 Allen John W Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
FR2853551B1 (fr) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee
WO2004092214A2 (fr) * 2003-04-10 2004-10-28 Aristex Systeme de purification par affinite au moyen de molecules de troponine en tant que ligands d'affinite
US20040241732A1 (en) * 2003-04-11 2004-12-02 Chu-An Chang Method of generating long nucleic acid molecules of defined sequence
US20050095610A1 (en) * 2003-04-11 2005-05-05 Kuo Sophia S. Method of generating size standard nucleic acids
US7402386B2 (en) 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
TWI375796B (en) * 2003-04-18 2012-11-01 Becton Dickinson Co Immuno-amplification
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
WO2004096985A2 (fr) * 2003-04-24 2004-11-11 Mayo Foundation For Medical Education And Research Procedes d'evaluation de la diversite biologique
CA2523490A1 (fr) * 2003-04-25 2004-11-11 Sequenom, Inc. Procedes et systemes de fragmentation et systemes de sequencage de novo
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
CA2523875A1 (fr) * 2003-04-28 2004-11-11 Public Health Agency Of Canada Sequences de nucleotides et d'acides amines du virus du sras, et utilisations associees
WO2004098497A2 (fr) * 2003-04-28 2004-11-18 Genencor International, Inc. Epitopes cd4+ du papillomavirus
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
CA2521284C (fr) 2003-04-29 2014-07-08 Pioneer Hi-Bred International, Inc. Genes de la glyphosate-n-acetyltransferase (gat)
JP2006525028A (ja) 2003-05-02 2006-11-09 ダウ・アグロサイエンシーズ・エルエルシー トウモロコシイベントtc1507およびそれを検出するための方法
ES2347658T3 (es) 2003-05-02 2010-11-03 Novozymes Inc. Variantes de beta-glucosidasas.
EP3552627A1 (fr) 2003-05-06 2019-10-16 Bioverativ Therapeutics Inc. Coagulation des protéines chimériques de facteur fc pour traiter l'hémophilie
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US20060252120A1 (en) * 2003-05-09 2006-11-09 Kieliszewski Marcia J Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
AU2003229474A1 (en) * 2003-05-09 2004-11-26 Capital Biochip Company, Ltd. Methods and compositions for detecting sars virus
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
EP1625203B1 (fr) 2003-05-15 2015-04-08 Xy, Llc Tri efficace de cellules haploides pour systemes de cytometrie en flux
CA2525647A1 (fr) 2003-05-16 2005-02-24 Intermune, Inc. Ligands des recepteurs des chimiokines synthetiques et leurs methodes d'utilisation
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7173010B2 (en) * 2003-05-19 2007-02-06 Regents Of The University Of Michigan Orphanin FQ receptor
ATE493508T1 (de) * 2003-05-19 2011-01-15 Univ Brandeis Verfahren, kits und vorrichtungen zur prozessierung von nukleinsäuren
EP1633893B1 (fr) 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methodes et kits de detection de la presence de trichomonas vaginalis dans un echantillon d'essai
US20040235032A1 (en) * 2003-05-19 2004-11-25 Canon Kabushiki Kaisha PCR amplification method, PCR primer set, PCR amplification product, and method for detection of nucleic acid using the amplification method
EP1625148B1 (fr) 2003-05-21 2012-09-26 Biotech Tools S.A. Complexe peptidique
BR122016024209B1 (pt) 2003-05-22 2019-08-20 Evogene Ltd. Método para aumentar a biomassa e/ou tolerância de uma planta ao estresse salino e construto de ácido nucleico
CA2526533C (fr) 2003-05-22 2014-01-14 Dow Agrosciences Llc Procedes de criblage a haut debit d'adn pour deletion et autres mutations
AU2005234725B2 (en) * 2003-05-22 2012-02-23 Evogene Ltd. Methods of Increasing Abiotic Stress Tolerance and/or Biomass in Plants and Plants Generated Thereby
US7554007B2 (en) * 2003-05-22 2009-06-30 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants
US20050020499A1 (en) * 2003-05-27 2005-01-27 Bar Ilan University Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method
US7655833B2 (en) 2003-05-29 2010-02-02 Brookhaven Science Associates, Llc ADS genes for reducing saturated fatty acid levels in seed oils
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
US7595176B2 (en) * 2003-05-30 2009-09-29 Georgia Tech Research Corporation Methods and reagents for quantitative analysis of Dehalococcoides species
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
BRPI0410972C1 (pt) 2003-06-03 2021-05-25 Novo Nordisk As método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia
FR2855832B1 (fr) * 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
ATE529126T1 (de) 2003-06-03 2011-11-15 Novo Nordisk As Stabilisierte pharmazeutische peptid zusammensetzungen
US20050232926A1 (en) * 2003-06-06 2005-10-20 Oncomax Acquisition Corp. Antibodies specific for cancer associated antigen SM5-1 and uses thereof
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
CN1279056C (zh) * 2003-06-06 2006-10-11 马菁 肿瘤相关抗原sm5-1的特异性抗体及其应用
EP1633860A2 (fr) 2003-06-09 2006-03-15 Wyeth AMELIORATIONS APPORTEES A UN PROCEDE DE RECUPERATION DE VIRUS A ARN DE POLARITE NEGATIVE NON SEGMENTE A PARTIR D'ADNc
EP2327795B1 (fr) 2003-06-10 2017-08-09 The Trustees Of Boston University Méthodes de détection de troubles poulmonaires
WO2004111217A2 (fr) 2003-06-13 2004-12-23 Danisco A/S Polypeptide
US8129514B2 (en) * 2003-06-19 2012-03-06 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
US7498428B2 (en) * 2003-06-19 2009-03-03 Evogene Ltd. Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same
AU2004265250C1 (en) 2003-06-23 2008-05-01 Pioneer Hi-Bred International, Inc. Engineering single-gene-controlled staygreen potential into plants
MXPA06000212A (es) 2003-06-25 2006-03-21 Novozymes As Enzimas para procesar almidon.
CA2538349C (fr) 2003-06-25 2014-08-12 Novozymes A/S Polypeptides a activite alpha-amylase et polynucleotides codant pour ceux-ci
ES2517245T3 (es) 2003-06-25 2014-11-03 Novozymes A/S Enzimas para el tratamiento de almidón
EP1644538A4 (fr) * 2003-06-26 2006-11-08 Invitrogen Corp Procedes et compositions permettant de detecter une activite de promoteur et d'exprimer des proteines de fusion
US20100291637A1 (en) * 2003-06-30 2010-11-18 Panasonic Corporation Method for modifying nucleotide chain
AU2004251522C1 (en) 2003-06-30 2011-12-15 Tel Aviv University Future Technology Development L.P. Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
JP2007528707A (ja) * 2003-06-30 2007-10-18 マサチューセッツ インスティテュート オブ テクノロジー 統合失調症の診断および治療のための標的としてのegr遺伝子
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
US20070077629A1 (en) * 2003-06-30 2007-04-05 Shigeki Joko Method for modifying nucleotide chain
EP2404929B1 (fr) 2003-07-02 2014-06-18 BP Corporation North America Inc. Glucanases, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
ES2354238T3 (es) 2003-07-03 2011-03-11 University Of Medicine And Dentistry Of New Jersey Genes como herramienta de diagnóstico para autismo.
MXPA06000365A (es) 2003-07-07 2006-03-28 Danisco Aditivo alimentario que comprende variantes de exoamilasa no maltogenica de pseudomonas.
US8143048B2 (en) * 2003-07-07 2012-03-27 Danisco A/S Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof
US20060057766A1 (en) * 2003-07-08 2006-03-16 Quanxi Jia Method for preparation of semiconductive films
ATE534900T1 (de) 2003-07-09 2011-12-15 Life Technologies Corp Verfahren zum testen einer protein-protein- wechselwirkung
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
FR2857375B1 (fr) * 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
CA2532228C (fr) 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans un lipide
MXPA06000794A (es) 2003-07-22 2006-08-23 Astex Therapeutics Ltd Compuestos 1h-pirazola 3,4-disustituida y su uso como moduladores de quinasas dependientes de ciclina (cdk) y quinasa-3 de sintasa de glicogeno (gsr-3).
CN1882688B (zh) 2003-07-25 2014-07-16 安比恩股份有限公司 用于分离小rna分子的方法和组合物
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US20050026147A1 (en) * 2003-07-29 2005-02-03 Walker Christopher L. Methods and compositions for amplification of dna
CN100482794C (zh) * 2003-07-29 2009-04-29 大制药株式会社 用于判定药物性粒细胞过少症发病几率的寡核苷酸、检测用试剂盒及其用途
AU2004260665B2 (en) * 2003-07-30 2007-11-15 Vlp Biotech, Inc. Hepatitis virus core proteins as vaccine platforms and methods of use thereof
US7144712B2 (en) * 2003-07-30 2006-12-05 Vaccine Research Institute Of San Diego Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
US7320795B2 (en) * 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
EP2407243B1 (fr) 2003-07-31 2020-04-22 Handylab, Inc. Dispositif multicouche microfluidique
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
CA2534349C (fr) 2003-08-01 2012-04-10 Stratatech Corporation Equivalents de peau humaine exprimant des polypeptides exogenes
EP1660631B1 (fr) * 2003-08-01 2013-04-24 Life Technologies Corporation Compositions et procedes de purification de courtes molecules d'arn
US20050069926A1 (en) * 2003-08-01 2005-03-31 Affymetrix, Inc. Helicase-amplified reverse transcription
WO2005012526A1 (fr) 2003-08-04 2005-02-10 The Hospital For Sick Children Gene de la maladie de lafora
SG145745A1 (en) 2003-08-06 2008-09-29 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
NZ545086A (en) 2003-08-07 2011-06-30 Healor Ltd Pharmaceutical compositions and methods for accelerating wound healing
WO2005021714A2 (fr) 2003-08-11 2005-03-10 Diversa Corporation Laccases, acides nucleiques codant pour ces enzymes et procedes permettant de les produire et de les utiliser
AU2004203649B2 (en) 2003-08-12 2006-01-12 F. Hoffmann-La Roche Ag Thermostable Taq polymerase fragment
JP2007518394A (ja) * 2003-08-14 2007-07-12 ザ バイオ バランス コーポレイション 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用
WO2005021546A1 (fr) * 2003-08-22 2005-03-10 Avanir Pharmaceuticals Derives de naphtyridine substitues servant d'inhibiteurs de facteur d'inhibition de la migration des macrophages et leur utilisation pour traiter des maladies humaines
DK2377931T3 (da) 2003-08-25 2013-07-08 Novozymes Inc Varianter af glycosidhydrolase
US20100069264A1 (en) * 2003-08-27 2010-03-18 Gil Sharon Libraries of recombinant chimeric proteins
US20060205072A1 (en) * 2003-08-27 2006-09-14 Nobuko Uchida Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
DE602004032042D1 (de) 2003-08-27 2011-05-12 Proterec Ltd Bibliotheken rekombinanter chimärischer proteine
WO2005074417A2 (fr) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Dosages de detection d'antigenes multiples et reactifs correspondants
CN1874720B (zh) 2003-09-03 2010-11-17 生命修复国际股份有限公司 个人诊断装置
DE602004008658T2 (de) * 2003-09-05 2008-06-12 Cellzome Ag Behandlung neurodegenerativer krankheiten
WO2005024068A2 (fr) * 2003-09-05 2005-03-17 Sequenom, Inc. Analyse de variations de sequences alleles specifiques
NZ545364A (en) * 2003-09-05 2009-06-26 Genencor Int HPV CD8+ T-cell epitopes
CN1863908B (zh) 2003-09-09 2010-08-04 诺和诺德医疗保健公司 凝固因子ⅶ多肽
US20050059035A1 (en) * 2003-09-09 2005-03-17 Quest Diagnostics Incorporated Methods and compositions for the amplification of mutations in the diagnosis of cystic fibrosis
US20120122096A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20070243595A1 (en) * 2006-04-14 2007-10-18 Clarkson Kathleen A Modified enzymes, methods to produce modified enzymes and uses thereof
CA2538837C (fr) * 2003-09-15 2016-02-09 Genencor International, Inc. Xylanases modifiees ayant une meilleure stabilite thermique et une meilleure stabilite en milieu alcalin
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050112634A1 (en) * 2003-09-19 2005-05-26 Woudenberg Timothy M. High density sequence detection methods and apparatus
SI2932981T1 (sl) 2003-09-19 2021-11-30 Novo Nordisk A/S Albumin-vezavni derivati GLP-1
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
US20060024690A1 (en) * 2003-09-19 2006-02-02 Kao H P Normalization of data using controls
EP1668034A1 (fr) * 2003-09-19 2006-06-14 Leukotech A/S Anticorps pro-inflammatoires et anti-inflammatoires luttant contre la proteine liant l'heparine (hbp)
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
US7788039B2 (en) * 2003-09-25 2010-08-31 Roche Molecular Systems, Inc. Quantitation of nucleic acids using growth curves
US7517647B2 (en) * 2003-09-29 2009-04-14 New York University Genetic screen for bioactive peptides
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
MXPA06003572A (es) * 2003-09-30 2006-08-31 Lexicon Genetics Inc Metodos y composiciones para definir la funcion genetica.
US7074567B2 (en) * 2003-09-30 2006-07-11 Reliagene Technologies Inc. Assay for human DNA for gender determination
US7537889B2 (en) * 2003-09-30 2009-05-26 Life Genetics Lab, Llc. Assay for quantitation of human DNA using Alu elements
US7432362B2 (en) * 2003-09-30 2008-10-07 Reliagene Technologies Inc. Assay for human DNA for gender determination
FR2860518B1 (fr) * 2003-10-01 2006-02-17 Biomerieux Sa Procede pour le diagnostic/pronostic du neuroblastome
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
US7625707B2 (en) 2003-10-02 2009-12-01 Ramot At Tel Aviv University Ltd. Antibacterial agents and methods of identifying and utilizing same
US7537890B2 (en) * 2003-10-03 2009-05-26 The Regents Of The University Of Michigan Methods of performing biochemical reactions in a convective flow field
EP1892306A3 (fr) 2003-10-06 2008-06-11 Bayer HealthCare AG Méthode et trousses pour évaluer un cancer
CN102517381A (zh) 2003-10-07 2012-06-27 千年药品公司 用于鉴定、评价、预防和治疗卵巢癌的核酸分子和蛋白质
ATE509034T1 (de) 2003-10-07 2011-05-15 Yeda Res & Dev Antikörper gegen nik, deren herstellung und verwendung
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
WO2005035788A2 (fr) * 2003-10-10 2005-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Procede et kit d'evaluation de l'anxiete ou de disposition a l'anxiete chez un sujet
WO2005035569A2 (fr) * 2003-10-10 2005-04-21 Five Prime Therapeutics, Inc. Kiaa0779, ses variantes epissees et procede de leur utilisation
BRPI0415435A (pt) * 2003-10-13 2006-12-05 Genaco Biomedical Products Inc método e kit para amplificação baseada em iniciador de ácidos nucleicos
US20050186588A1 (en) * 2003-10-16 2005-08-25 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
EP1677735B1 (fr) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Methodes et compositions pour moduler la fonction des adipocytes
AU2004286235B2 (en) 2003-10-21 2011-05-12 Orion Genomics Llc Differential enzymatic fragmentation
CA2542221A1 (fr) * 2003-10-23 2005-05-06 Pfizer Products Inc. Vaccin contre les parodontopathies
CN1910293B (zh) 2003-10-23 2011-04-13 伊洛默格生物科学公司 检测与抗病毒感染性有关的基因oas1中的突变的方法
PL1687609T3 (pl) * 2003-10-28 2015-05-29 Epoch Biosciences Inc Sondy fluoroscencyjne do wykrywania DNA przez hybrydyzację o ulepszonej czułości i niskim tle
AU2004286845A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
ATE486087T1 (de) * 2003-11-06 2010-11-15 Danisco Us Inc Fgf-5-bindende und geträgerte peptide
AU2006246425B2 (en) 2003-11-06 2012-03-22 Genencor International, Inc. Personal care compositions and methods for their use
JP2007512811A (ja) * 2003-11-10 2007-05-24 インベスチゲン, インコーポレイテッド 検出のための核酸を調製する方法
AU2004290049B2 (en) 2003-11-12 2011-09-29 The Regents Of The University Of Colorado Compositions and methods for regulation of tumor necrosis factor-alpha
US7169560B2 (en) * 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
CA2542574C (fr) 2003-11-12 2014-03-18 E. I. Du Pont De Nemours And Company Delta-15 desaturases appropriees pour modifier les niveaux d'acides gras polyinsatures dans des plantes a graines oleagineuses et de la levure oleagineuse
EP1691836B1 (fr) * 2003-11-13 2012-02-22 Sutter West Bay Hospitals Traitement anti-pecam destine a la suppression de la metastase
WO2005049849A2 (fr) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Colorants azo d'extinction de fluorescence, leurs procedes de preparation et d'utilisation
CA2545917C (fr) 2003-11-14 2014-07-29 Duke University Procede de detection de la maladie de charcot-marie de type 2a
JP4581380B2 (ja) * 2003-11-17 2010-11-17 パナソニック株式会社 核酸増幅反応容器およびその製造方法
US20050125914A1 (en) * 2003-11-18 2005-06-16 Gerard Malle Hair shaping composition comprising at least one- non-hydroxide base
US7985569B2 (en) 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
US20060094064A1 (en) * 2003-11-19 2006-05-04 Sandip Ray Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
US7598049B2 (en) * 2003-11-19 2009-10-06 Satoris, Inc. Methods for diagnosis of Alzheimer's Disease in blood samples
WO2005054435A2 (fr) * 2003-11-26 2005-06-16 Eppendorf Ag Procedes et compositions pour l'amplification in vitro d'acide nucleique extrachromosomique
WO2005054810A2 (fr) * 2003-11-26 2005-06-16 The Ohio State University Research Foundation Genotypes cd24 polymorphes indicateurs d'un risque et d'une progression de sclerose en plaques
JP4790621B2 (ja) 2003-11-26 2011-10-12 アドバンディーエックス, インコーポレイテッド 特定のStaphylococcus種の分析のためのペプチド核酸プローブ
CA3050151C (fr) 2003-11-26 2023-03-07 Celera Corporation Polymorphismes nucleotides simples associes a des troubles cardiovasculaires et a une reponse au medicament, leurs procedes de detection et d'utilisation
WO2005051423A2 (fr) 2003-11-30 2005-06-09 Yeda Research And Development Co. Ltd Procedes et agents pour mettre en oeuvre une modulation immunitaire et procedes d'identification de modulateurs immunitaires
WO2005054438A2 (fr) 2003-12-01 2005-06-16 Invitrogen Corporation Molecule d'acide nucleique contenant des sites de recombinaison et leurs procedes d'utilisation
US8034790B2 (en) * 2003-12-01 2011-10-11 Introgen Therapeutics Use of MDA-7 to inhibit pathogenic infectious organisms
EP1692315A1 (fr) 2003-12-02 2006-08-23 Roche Diagnostics GmbH Procede ameliore de traitement au bisulfite
MXPA06005652A (es) 2003-12-03 2006-08-17 Genencor Int Perhidrolasa.
US20060122783A1 (en) * 2004-08-24 2006-06-08 Ishikawa Muriel Y System and method for heightening a humoral immune response
US20060122784A1 (en) * 2004-12-03 2006-06-08 Ishikawa Muriel Y System and method for augmenting a humoral immune response
US20060095211A1 (en) * 2003-12-05 2006-05-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and method for modulating a cell mediated immune response
US20060116824A1 (en) * 2004-12-01 2006-06-01 Ishikawa Muriel Y System and method for modulating a humoral immune response
US20060047434A1 (en) * 2004-08-24 2006-03-02 Ishikawa Muriel Y System and method related to improving an immune system
US20060047436A1 (en) * 2004-08-25 2006-03-02 Ishikawa Muriel Y System and method for magnifying an immune response
US20060047435A1 (en) * 2004-08-24 2006-03-02 Ishikawa Muriel Y System and method related to augmenting an immune system
US20060047437A1 (en) * 2004-08-25 2006-03-02 Ishikawa Muriel Y System and method for heightening an immune response
US20060182742A1 (en) * 2004-08-24 2006-08-17 Ishikawa Muriel Y System and method for magnifying a humoral immune response
EP1699926B1 (fr) 2003-12-10 2014-06-18 Monsanto Technology, LLC Plantes tolerantes de stress et leurs procedes
DK1694846T3 (en) 2003-12-10 2014-11-17 Novozymes As Cell with enhanced secretion mediated by MrgA protein or a homolog
US20050130897A1 (en) * 2003-12-11 2005-06-16 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
AU2004300168A1 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
WO2005059100A2 (fr) * 2003-12-12 2005-06-30 New York University Procedes et compositions se rapportant a la cystatine c
PT1708560E (pt) 2003-12-15 2015-06-03 Monsanto Technology Llc Planta de milho mon88017 e composições e métodos para a sua detecção
US20100221233A1 (en) * 2003-12-15 2010-09-02 University Of South Florida Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
WO2005058479A2 (fr) 2003-12-17 2005-06-30 Praecis Pharmaceuticals, Inc. Procedes de synthese de bibliotheques codees
US7129049B2 (en) 2003-12-22 2006-10-31 Regents Of The University Of Minnesota Method of detecting equine glycogen storage disease IV
EP2289567A3 (fr) 2003-12-22 2011-06-22 Regentis Biomaterials Ltd. Matrice à base de protéines naturelles réticulées
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8647873B2 (en) * 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
WO2005062955A2 (fr) 2003-12-23 2005-07-14 Rinat Neuroscience Corp. Anticorps anti-trkc agonistes et procedes d'utilisation
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
WO2007059007A2 (fr) 2005-11-14 2007-05-24 Cythera, Inc. Marqueurs d'endoderme definitif
KR101164258B1 (ko) 2003-12-23 2012-07-11 아스텍스 테라퓨틱스 리미티드 단백질 키나아제 조절제로서의 피라졸 유도체
NZ547920A (en) * 2003-12-23 2009-06-26 Cythera Inc Definitive endoderm
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7985585B2 (en) * 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
GB0716126D0 (en) 2007-08-17 2007-09-26 Danisco Process
JP5697294B2 (ja) 2003-12-24 2015-04-08 デュポン ニュートリション バイオサイエンシーズ エーピーエス 糖脂質アシル基転移酵素変異体及びその製造方法
US7906307B2 (en) 2003-12-24 2011-03-15 Danisco A/S Variant lipid acyltransferases and methods of making
CN1898386A (zh) 2003-12-24 2007-01-17 丹尼斯科公司 蛋白质
US7718408B2 (en) 2003-12-24 2010-05-18 Danisco A/S Method
TW201037080A (en) * 2003-12-25 2010-10-16 Danform Kk Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
US20050147979A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
EP1706424B1 (fr) 2004-01-12 2009-07-22 Applied Molecular Evolution, Inc. Variants de la region fc
US8007847B2 (en) * 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
WO2005069845A2 (fr) * 2004-01-14 2005-08-04 Ohio University Methodes de production de peptides/proteines dans des plantes et peptides/proteines ainsi produits
US20050158710A1 (en) * 2004-01-16 2005-07-21 Shirley Tsang Detection of enterovirus nucleic acid
US7423139B2 (en) * 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
AU2005207003C1 (en) 2004-01-20 2013-06-13 Humanigen, Inc. Antibody specificity transfer using minimal essential binding determinants
US7670771B2 (en) 2004-01-21 2010-03-02 University Of Utah Research Foundation Mutant sodium channel Nav1.7 nucleic acid methods
WO2005073409A2 (fr) * 2004-01-26 2005-08-11 Applera Corporation Methodes, compositions et trousses pour l'amplification et le sequençage de polynucleotides
AU2005206389A1 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby
US8293471B2 (en) * 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
US20050227563A1 (en) * 2004-01-30 2005-10-13 Bond Eric B Shaped fiber fabrics
DE102004004882A1 (de) * 2004-01-30 2005-08-18 Dade Behring Marburg Gmbh Testsystem und Verfahren zum Nachweis von Analyten
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
EP1758998B1 (fr) 2004-01-30 2010-12-15 Quark Pharmaceuticals, Inc. Oligoribonucleotides et procedes d'utilisation de ceux-ci dans le traitement d'etats fibreux et d'autres maladies
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
EP1718743B1 (fr) * 2004-02-04 2009-08-26 QIAGEN North American Holdings, Inc. Amplification d'acides nucleiques amelioree par proteines antigel
JP4892358B2 (ja) 2004-02-04 2012-03-07 ノヴォ ノルディスク アー/エス 哺乳動物グリコシルトランスフェラーゼをリフォールディングする方法
US8603969B2 (en) * 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same
US20050186606A1 (en) * 2004-02-11 2005-08-25 Schroeder Benjamin G. Methods and compositions for detecting nucleic acids
FR2866349B1 (fr) * 2004-02-12 2008-05-16 Biomerieux Sa Procede de diagnostic/pronostic d'une thrombose
US7360327B2 (en) * 2004-02-12 2008-04-22 Ralph L. Osgood, Inc. Material moving pusher/bucket
WO2005079474A2 (fr) 2004-02-17 2005-09-01 The Regents Of The University Of California Detection de differences de sequences d'acide nucleique par hybridation genomique comparative
US20050191682A1 (en) 2004-02-17 2005-09-01 Affymetrix, Inc. Methods for fragmenting DNA
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP1716254B1 (fr) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Procedes pour analyser des sequences de polynucleotides
WO2005083390A1 (fr) * 2004-02-20 2005-09-09 Research Foundation Of The State University Of New York Procede et dispositif servant à manipuler des liquides dans des systemes microfluidiques
ES2532609T3 (es) * 2004-02-20 2015-03-30 Ibio, Inc. Sistemas y métodos para expresión clonales en plantas
SE0400441D0 (sv) * 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
CA2557485A1 (fr) * 2004-02-26 2005-09-09 Thomsen Bioscience A/S Procede, puce, dispositif et systeme integre pour la detection de particules biologiques
ES2348951T3 (es) * 2004-02-26 2010-12-17 Delta Dansk Elektronik, Lys Og Akustik Procedimiento, chip y sistema para la recogida de particulas biologicas.
WO2005083078A1 (fr) * 2004-02-26 2005-09-09 Thomsen Bioscience A/S Procede, puce, dispositif et systeme permettant d'extraire des matieres biologiques
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
CA2560066A1 (fr) 2004-03-01 2005-09-15 The Cbr Institute For Biomedical Research, Inc. Anticorps naturels igm et leurs inhibiteurs
EP2208797A3 (fr) 2004-03-01 2010-11-24 Applied Biosystems, LLC Techniques, compositions et kits d'amplification de polynucleotide
US7456149B2 (en) 2004-03-02 2008-11-25 Acceleron Pharma, Inc. ALK7 and myostatin inhibitors and uses thereof
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US8338578B1 (en) 2004-03-05 2012-12-25 Quest Diagnostics Investments Incorporated Cystic fibrosis gene mutations
ATE508756T1 (de) 2004-03-05 2011-05-15 Gen Probe Inc Verfahren zur deaktivierung von nukleinsäuren
US20090087854A1 (en) 2007-09-27 2009-04-02 Perlegen Sciences, Inc. Methods for genetic analysis
CA2558811A1 (fr) 2004-03-08 2005-09-22 Zymogenetics, Inc. Proteines de fusion dimeres et materiaux et methodes de production de ces proteines
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
US20080025948A1 (en) * 2004-03-10 2008-01-31 Chih-Ping Liu Methods of Treatment Using Interferon-Tau
US20060078942A1 (en) * 2004-03-10 2006-04-13 Pepgen Corporation Method of treatment using interferon-tau
EP1574583A1 (fr) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Procédé pour isoler des bactéries des échantillons biologiques
JP2007529015A (ja) 2004-03-12 2007-10-18 バイオトローブ, インコーポレイテッド ナノリットルのアレイローディング
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
AU2005244249A1 (en) * 2004-03-17 2005-11-24 Novartis Vaccines And Diagnostics, Inc. Treatment of severe community-acquired pneumonia by admistration of tissue factor pathway inhibitor (TFPI)
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
CN1957256B (zh) 2004-03-24 2013-01-02 三路影像公司 用于子宫颈疾病检测的方法和组合物
EP2395098B1 (fr) * 2004-03-26 2015-07-15 Agena Bioscience, Inc. Division spécifique de base de produits d'amplification spécifique à la méthylation en combinaison avec une analyse de masse
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
BRPI0418683B8 (pt) 2004-03-26 2022-06-28 Dow Agrosciences Llc Polinucleotìdeos referentes aos eventos cry1f 281-24-236 e cry1ac 3006-210-23
WO2005093060A1 (fr) * 2004-03-26 2005-10-06 Nippon Shokubai Co., Ltd. Procede pour la productiond d'acide 1,3-propanediol et/ou 3-hydroxypropionique
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
WO2005095590A2 (fr) 2004-03-29 2005-10-13 Monsanto Technology Llc Suspensions a spermatozoides pour le tri de leurs populations selon leur richesse en chromosomes x ou y
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
FR2868433B1 (fr) * 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
JP4755174B2 (ja) * 2004-04-07 2011-08-24 ザ ユニヴァーシティー オヴ シカゴ 単量体赤色蛍光タンパク質
PL1732949T3 (pl) 2004-04-07 2010-06-30 Rinat Neuroscience Corp Sposoby leczenia nowotworowego bólu kości przez podawanie antagonisty czynnika wzrostu nerwów
US20090011463A1 (en) * 2004-04-09 2009-01-08 Walter Weyler Pcka Modifications and Enhanced Protein Expression in Bacillus
US7229800B2 (en) * 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
CA2573918A1 (fr) * 2004-04-19 2005-11-24 Ohio University Glycoproteines reticulables et leurs methodes de fabrication
US7595179B2 (en) * 2004-04-19 2009-09-29 Applied Biosystems, Llc Recombinant reverse transcriptases
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US20050239889A1 (en) * 2004-04-26 2005-10-27 Jean Gosselin In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration
US20080248465A1 (en) * 2004-04-26 2008-10-09 Uab Research Foundation Polymorphisms in the Fcgr2b Promoter and Uses Thereof
US7919277B2 (en) 2004-04-28 2011-04-05 Danisco A/S Detection and typing of bacterial strains
US7553813B2 (en) * 2004-04-30 2009-06-30 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
NZ580248A (en) 2004-04-30 2012-01-12 Dow Agrosciences Llc Plants comprising herbicide resistance gene encoding aryloxyalkanoate dioxygenase
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP1745153B1 (fr) 2004-05-03 2015-09-30 Handylab, Inc. Traitement d'échantillons contenant des polynucléotides
EP1751279A4 (fr) * 2004-05-05 2008-03-19 Univ Minnesota Acides nucleiques et polypeptides impliques dans la production de cryptophycine
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
EP2412827B1 (fr) 2004-05-07 2014-01-22 Celera Corporation Polymorphism génétique associée à des techniques de detection de cirrhose du foie et utilisation de ces polymorphismes
EP1747292B1 (fr) 2004-05-07 2015-07-08 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Methodes de diagnostic ou de traitement du cancer de la prostate au moyen du gene erg, seul ou combine a d'autres genes surexprimes ou sous-exprimes dans le cancer de la prostate
AP2773A (en) * 2004-05-13 2013-09-30 Nanobiosym Inc NANO-PCR: Methods and devices for nucleic acid amplification and detection
US20080124714A1 (en) * 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
AU2005257839A1 (en) 2004-05-17 2006-01-05 The General Hospital Corporation Methods and compositions for producing germ cells from bone marrow derived germline stem cells
US20060292554A1 (en) * 2004-05-18 2006-12-28 Genentech, Inc. Major coat protein variants for C-terminal and bi-terminal display
US7473551B2 (en) 2004-05-21 2009-01-06 Atonomics A/S Nano-mechanic microsensors and methods for detecting target analytes
ES2529044T3 (es) 2004-05-21 2015-02-16 Mo Bio Laboratories, Inc. Kits y procedimientos para eliminar contaminantes de ácidos nucleicos en muestras ambientales y biológicas
EP2458619B1 (fr) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Spectrométrie de masse avec filtration sélective d'ions par établissement de seuils numériques
EP1748790B1 (fr) 2004-05-24 2015-07-15 MedImmune, LLC Systeme multiplasmide pour la production d'un virus grippal
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
CA2566806A1 (fr) 2004-05-25 2006-01-19 Helicos Biosciences Corporation Procedes et dispositifs pour la determination de sequence d'acides nucleiques
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7575864B2 (en) * 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
WO2005121351A2 (fr) 2004-05-27 2005-12-22 Novozymes, Inc. Methodes permettant de transformer et de cribler l'expression de cellules de champignons filamenteux au moyen d'une bibliotheque d'adn
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
EP2290073A3 (fr) 2004-05-28 2011-08-31 Asuragen, Inc. Procédés et compositions impliquant du microARN
US7311794B2 (en) * 2004-05-28 2007-12-25 Wafergen, Inc. Methods of sealing micro wells
CN102453763A (zh) 2004-06-03 2012-05-16 阿什洛米克斯控股有限公司 诊断应激的药物和方法
US7858763B2 (en) * 2004-06-04 2010-12-28 Council Of Scientific And Industrial Research Transforming growth factor beta 1 (TGFβ1) haplotypes and prediction of susceptibility for immunological disorders
EP1766023B1 (fr) * 2004-06-04 2010-09-01 Fluxome Sciences A/S Cellules metaboliquement transformees pour la production d'acides gras polyinsaturates
EP2933630A3 (fr) 2004-06-07 2015-10-28 Fluidigm Corporation Système de lentille optique et procédé pour dispositifs microfluidiques
US7604947B2 (en) 2004-06-09 2009-10-20 Cornell Research Foundation, Inc. Detection and modulation of cancer stem cells
CN101027319A (zh) * 2004-06-10 2007-08-29 恩卡姆医药公司 肝素结合肽
CN101948846A (zh) 2004-06-14 2011-01-19 伊沃基因有限公司 参与植物纤维发育的多核苷酸和多肽和使用它们的方法
WO2007049275A2 (fr) 2005-10-24 2007-05-03 Evogene Ltd. Polypeptides isoles, polynucleotides codant pour ces derniers, plantes transgeniques exprimant ces derniers et methodes utilisant ces derniers
CN103173282A (zh) 2004-06-16 2013-06-26 帝斯曼知识产权资产管理有限公司 对叶绿素进行酶促脱色的组合物和方法
US20080311627A1 (en) * 2004-06-17 2008-12-18 Epigenomics Ag Compositions and Methods for Preventing Carry-Over Contamination in Nucleic Acid Amplification Reactions
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
AU2005254613A1 (en) * 2004-06-18 2005-12-29 Enkam Pharmaceuticals A/S FGFR binding peptides
JP2008503590A (ja) * 2004-06-21 2008-02-07 メドトロニック・インコーポレーテッド 組成物を細胞にデリバリーするための医学用システム及び方法
CA2571243A1 (fr) 2004-06-21 2006-01-05 The Board Of Trustees Of The Leland Stanford Junior University Genes et voies exprimes de maniere differentielle dans des troubles bipolaires et/ou troubles depressifs majeurs
EP1609871A1 (fr) * 2004-06-21 2005-12-28 Biolytix AG Procédés et kits de detection, d'identification et de quantification de bacteries et de levures dans la nourriture et les boissons.
EP1781810A1 (fr) * 2004-06-29 2007-05-09 Wallac Oy Amplification et detection integree, non homogene des acides nucleiques
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
US7217523B2 (en) * 2004-07-02 2007-05-15 Regents Of The University Of Minnesota Nucleoside phosphoramidates and nucleoside phosphoramidases
EP1768688A4 (fr) * 2004-07-02 2009-09-30 Raymond J Dattwyler Vaccin oral permettant de lutter contre des infections a borrelia
US7566532B1 (en) 2004-07-02 2009-07-28 Quest Diagnostics Investments Incorporated Methods for detecting retroviruses
JP4955546B2 (ja) 2004-07-05 2012-06-20 ノボザイムス アクティーゼルスカブ 変更された性質を有するα−アミラーゼ変異体
US8680062B2 (en) 2004-07-06 2014-03-25 Deliversir Ltd. System for delivering therapeutic agents into living cells and cells nuclei
DK1769069T3 (en) * 2004-07-07 2018-02-05 Genencor Int NOT MALOGUES EXOAMYLASE VARIETIES
US20090111730A1 (en) 2004-07-08 2009-04-30 Novo Nordisk A/S Polypeptide protracting tags
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
EP1767655A4 (fr) 2004-07-13 2007-08-01 Takeda Pharmaceutical Méthode de contrôle des fonctions d'une cellule
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
WO2006006172A2 (fr) * 2004-07-15 2006-01-19 Ramot At Tel Aviv University Ltd. Utilisation d'agents anti-amyloides pour traiter et determiner des infections pathogenes
AU2005263954B2 (en) 2004-07-16 2011-04-07 Dupont Nutrition Biosciences Aps Enzymatic oil-degumming method
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
WO2006112869A2 (fr) * 2004-07-19 2006-10-26 Baylor College Of Medicine Modulation des regulateurs de la signalisation des cytokines et applications en immunotherapie
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
GB2416352B (en) * 2004-07-21 2009-01-28 Bioline Ltd A method for performing the hot start of enzymatic reactions
US20090226552A1 (en) * 2004-07-22 2009-09-10 Colorado State University Research Foundation Agents and methods for diagnosing osteoarthritis
WO2006012597A2 (fr) 2004-07-22 2006-02-02 Monsanto Technology Llc Procede pour enrichir une population de spermatozoides
EP1773860A4 (fr) * 2004-07-22 2009-05-06 Sequenom Inc Méthodes d'évaluation du risque d"apparition de diabètes de type ii et traitements associés
WO2006008547A1 (fr) * 2004-07-23 2006-01-26 Ge Healthcare Uk Limited Rapport de lignee cellulaire dans un cycle cellulaire
FR2873388B1 (fr) * 2004-07-23 2012-04-06 Biomerieux Sa Procede de marquage et de purification d'acides nucleiques d'interet presents dans un echantillon biologique a traiter dans un unique recipient reactionnel
US7745123B2 (en) * 2004-07-23 2010-06-29 Ge Healthcare Uk Limited Cell cycle reporting cell line
US8821884B2 (en) * 2004-07-27 2014-09-02 The Regents Of The University Of California Compositions and methods using MD-2 mutants and chimeric proteins
EP1789437A4 (fr) * 2004-07-30 2008-11-05 Sinai School Medicine Inhibiteurs de npc1l1 et npc1l1 et procédés d'utilisation associés
DK2299275T3 (en) 2004-07-30 2018-05-07 Adeza Biomedical Corp Classification of oncofetal fetronectin level for pregnancy-related indications
JP5042828B2 (ja) 2004-07-30 2012-10-03 ライナット ニューロサイエンス コーポレイション アミロイド−ベータ・ペプチドに対して向けられる抗体、および該抗体を用いる方法
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
JP4820756B2 (ja) 2004-08-05 2011-11-24 ユニバーサル・バイオ・リサーチ株式会社 反応容器、反応容器液導入装置、液導入反応測定装置、および液導入装置
EP1623996A1 (fr) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Procédé amélioré de selection d'une protéine desirée d'une bibliothéque.
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
MX2007001589A (es) * 2004-08-09 2007-08-02 Alios Biopharma Inc Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas.
US20060073168A1 (en) * 2004-08-11 2006-04-06 Stephens David S Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions
US7585626B1 (en) 2004-08-19 2009-09-08 Quest Diagnostics Investments Incorporated Methods for nucleic acid amplification
US7732479B2 (en) 2004-08-19 2010-06-08 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US20070265787A1 (en) * 2004-08-24 2007-11-15 Searete Llc,A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for magnifying cell-mediated immune response
US20070265818A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for heightening cell-mediated immune response
WO2006135400A2 (fr) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Procedes pour l'identification rapide d'organismes recombinants
US20070198196A1 (en) * 2004-08-24 2007-08-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods relating to ameliorating an immune system
US20070207492A1 (en) * 2004-08-24 2007-09-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems to adjust a humoral immune response
US20070265788A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems for augmenting cell-mediated immune response
US20070265817A1 (en) * 2004-08-24 2007-11-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods relating to fortifying an immune system
US20070288173A1 (en) * 2004-08-24 2007-12-13 Searete Llc, A Limited Liability Corporation Of The State Of Delware Computational methods and systems to reinforce a humoral immune response
US20060047439A1 (en) * 2004-08-24 2006-03-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and method for improving a humoral immune response
US20070196362A1 (en) * 2004-08-24 2007-08-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems to bolster an immune response
EP2071031B1 (fr) 2004-08-27 2013-10-09 Gen-Probe Incorporated Procédés d'amplification d'acide nucléique à simple amorce
US20060057624A1 (en) * 2004-08-30 2006-03-16 Potashkin Judith A Alternatively spliced pre-mRNA transcripts in neurodegenerative disease
US20070087376A1 (en) * 2004-08-30 2007-04-19 Potashkin Judith A Splice variants of pre-mRNA transcripts as biomarkers in idiopathic neurodegenerative diseases
US7456270B2 (en) * 2004-09-01 2008-11-25 Abbott Laboratories Δ6-desaturase genes and uses thereof
JP4440857B2 (ja) 2004-09-01 2010-03-24 三星電子株式会社 リアルタイム核酸増幅データから初期核酸濃度を定量化する方法
KR100738073B1 (ko) 2004-09-01 2007-07-12 삼성전자주식회사 실시간 핵산 증폭 데이터로부터 초기 핵산 농도를정량화하는 방법
EP1632578A1 (fr) 2004-09-03 2006-03-08 Roche Diagnostics GmbH Méthode pour la décontamination de l' ADN
US20060057627A1 (en) * 2004-09-08 2006-03-16 Board Of Regents, The University Of Texas System Selection scheme for enzymatic function
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
WO2006031745A2 (fr) * 2004-09-10 2006-03-23 Sequenom, Inc. Methodes d'analyse de sequence d'acide nucleique superieure
CN104644627A (zh) 2004-09-14 2015-05-27 科罗拉多大学董事会 基于基因靶向使用布新洛尔的治疗方法
PT1794327T (pt) 2004-09-14 2017-01-24 Argos Therapeutics Inc Amplificação independente de estirpes de patogénios e vacinas para os mesmos
WO2006031843A2 (fr) 2004-09-14 2006-03-23 John Wayne Cancer Institute Detection de cellules cancereuses dans des liquides biologiques
US20060063187A1 (en) * 2004-09-15 2006-03-23 Hotamisligil Gokhan S Modulation of XBP-1 activity for treatment of metabolic disorders
WO2006030442A2 (fr) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methodes de culture ex vivo de cellules souches et de precurseur par co-culture avec des cellules mesenchymales
FI20041204A0 (fi) 2004-09-16 2004-09-16 Riikka Lund Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
EP1647600A3 (fr) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Méthodes pour identifier les échantillons biologiques par l'addition des étiquettes de code à barres d'acide nucléique
US20060068430A1 (en) * 2004-09-20 2006-03-30 Sigma-Aldrich Co. Purification of biomolecules from contaminating intact nucleic acids
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
JP2008513028A (ja) * 2004-09-21 2008-05-01 アプレラ コーポレイション マイクロRNA(miRNA)の二色リアルタイム/エンドポイント定量化
CN102643818B (zh) 2004-09-28 2014-04-09 夸克制药公司 寡核糖核苷酸以及其用于治疗脱发、肾衰竭和其它疾病的方法
KR20070083870A (ko) 2004-09-29 2007-08-24 콜플랜트 리미티드 콜라겐 생산성 식물 및 그 생성 및 사용방법
FR2876116B1 (fr) * 2004-10-01 2007-04-06 Biomerieux Sa Methode pour generer des transcrits
GB0422052D0 (en) 2004-10-04 2004-11-03 Dansico As Enzymes
US20060073489A1 (en) 2004-10-05 2006-04-06 Gangqiang Li Nanopore separation devices and methods of using same
EP1645640B1 (fr) 2004-10-05 2013-08-21 Affymetrix, Inc. Procédé pour la détection des translocations chromosomales
EP1801196A4 (fr) 2004-10-06 2011-06-15 Universal Bio Research Co Ltd Cuve de reaction et module de commande de reaction
EP1799711B1 (fr) 2004-10-07 2012-06-20 Novo Nordisk A/S Composes d'exendin-4 a action prolongee
CA2577125C (fr) 2004-10-07 2016-01-12 Argos Therapeutics, Inc. Compositions de cellules dendritiques matures et procedes de mise en culture correspondants
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7781402B2 (en) * 2004-10-12 2010-08-24 Closed Loop Therapies Ltd. Methods and implantable devices for treating supraventricular arrhythmias
US20090319045A1 (en) * 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
CA2996947C (fr) * 2004-10-18 2019-02-26 Brandeis University Amorces, sondes et procedes d'amplification d'acides nucleiques
GB0423139D0 (en) 2004-10-18 2004-11-17 Danisco Enzymes
US7445896B2 (en) * 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
NZ554701A (en) * 2004-10-18 2010-03-26 Univ Brandeis Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
FR2876705B1 (fr) * 2004-10-19 2008-12-12 Biomerieux Sa Procede pour le diagnostic d'une intolerance a l'aspirine
US20060115838A1 (en) * 2004-10-19 2006-06-01 Trevigen Inc. Real-time detection of amplicons using nucleic acid repair enzymes
US20060188937A1 (en) * 2004-10-19 2006-08-24 Board Of Regents, The University Of Texas System G-protein estrogen membrane receptor
EP2298341A3 (fr) 2004-10-21 2011-07-13 Wyeth LLC Composition immunogene de staphylococcus epidermidis polypeptide et polynucleotide antigenes
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US8133703B2 (en) 2004-10-27 2012-03-13 Ceoheid Closed-system multi-stage nucleic acid amplification reactions
JP2008520191A (ja) 2004-10-27 2008-06-19 バンダービルト・ユニバーシティ 感染に関与する哺乳動物遺伝子
JP2006126204A (ja) 2004-10-29 2006-05-18 Affymetrix Inc ポリマーアレイを製造するための自動化方法
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP2266602A3 (fr) 2004-11-01 2011-08-10 Novartis Vaccines and Diagnostics, Inc. Approches combinatoires destinées à produire des réponses immunitaires
ES2391744T3 (es) 2004-11-01 2012-11-29 George Mason University Composiciones y procedimientos para el diagnóstico de trastornos del colon
CA2586246A1 (fr) * 2004-11-03 2006-05-11 Third Wave Technologies, Inc. Biotest de detection d'acide nucleique en une seule etape ayant recours a la transcription inverse, a la reaction en chaine a la polymerase et au clivage endonucleolytique
CA2585781A1 (fr) 2004-11-03 2006-12-28 Iris Molecular Diagnostics, Inc. Detection homogene de substance a analyser
GB0424940D0 (en) 2004-11-11 2004-12-15 Danisco Transcription factors
EP2302055B1 (fr) 2004-11-12 2014-08-27 Asuragen, Inc. Procédés et compositions impliquant l'ARNmi et des molécules inhibitrices de l'ARNmi
WO2008073922A2 (fr) 2006-12-08 2008-06-19 Asuragen, Inc. Fonctions et cibles de microarn let-7
US7051536B1 (en) * 2004-11-12 2006-05-30 Bio-Rad Laboratories, Inc. Thermal cycler with protection from atmospheric moisture
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
EP1812473A4 (fr) 2004-11-16 2009-12-23 Univ Boston Role du recepteur dear dans l'hypertension et l'angiogenese
US20060110724A1 (en) 2004-11-19 2006-05-25 Burkhardt William Iii Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard
EP1666150B1 (fr) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Préparation d'acide nucléique
EP1825005B1 (fr) * 2004-11-24 2015-07-15 The Regents of the University of Colorado, a body corporate Agents diagnostiques et therapeutiques a base de mer
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
GB2420560A (en) 2004-11-30 2006-05-31 Bioline Ltd A method for increasing the specificity of enzymatic DNA synthesis
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
EP1836317A2 (fr) * 2004-12-06 2007-09-26 BioVeris Corporation Procedes et compositions pour la detection de bacillus anthracis
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
JP4534138B2 (ja) * 2004-12-21 2010-09-01 アイシン精機株式会社 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
ES2552635T3 (es) 2004-12-22 2015-12-01 Novozymes A/S Polipéptidos con actividad de glucoamilasa y codificación de polinucleótidos
AR051863A1 (es) 2004-12-22 2007-02-14 Novozymes As Enzimas hibridas
CA2591221A1 (fr) * 2004-12-23 2006-07-06 Genencor International, Inc. Noyau catalytique de cellulase neutre et procede d'elaboration
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
CA2491067A1 (fr) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Rapport entre arnm dans les sediments urinaires ou l'urine en tant que marqueur pronostique du cancer de la prostate
US7736818B2 (en) 2004-12-27 2010-06-15 Inphase Technologies, Inc. Holographic recording medium and method of making it
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
BRPI0519759A2 (pt) 2004-12-30 2009-03-10 Astex Therapeutics Ltd composiÇÕes farmacÊuticas
WO2006074233A2 (fr) * 2005-01-06 2006-07-13 Applera Corporation Polypeptides presentant une activite de liaison d'acides nucleiques, composition et procedes permettant d'amplifier des acides nucleiques
ES2589582T3 (es) * 2005-01-07 2016-11-15 Monsanto Invest B.V. Virus de plantas denominado virus del torrado del tomate
ES2363094T3 (es) 2005-01-10 2011-07-20 Novozymes A/S Proceso para la producción de ésteres alquílicos de ácidos grasos a partir de triglicéridos y alcoholes que utilizan una combinación de dos enzimas lipolíticas.
EP1844403A4 (fr) * 2005-01-16 2010-06-23 Zlango Ltd Communication iconique
WO2006075335A2 (fr) * 2005-01-16 2006-07-20 Zlango Ltd. Systeme de reseau de communication et procedes d'utilisation
WO2007080558A2 (fr) * 2006-01-16 2007-07-19 Zlango Ltd. Systeme de reseau de communication et ses procedes d'utilisation
WO2006079033A2 (fr) * 2005-01-21 2006-07-27 Gene Express, Inc. Procedes et compositions pour evaluer des acides nucleiques
WO2006077424A1 (fr) 2005-01-21 2006-07-27 Astex Therapeutics Limited Composes pharmaceutiques
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
JP2008528060A (ja) 2005-01-27 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ボツリヌス神経毒素を中和する治療的モノクローナル抗体
US9505846B2 (en) 2005-01-28 2016-11-29 Life Technologies Corporation Multi-component inhibitors of nucleic acid polymerases
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US9101927B2 (en) 2005-01-31 2015-08-11 Realbio Technologies Ltd. Multistep reaction lateral flow capillary device
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
KR20070112785A (ko) 2005-02-01 2007-11-27 에이젠코트 바이오사이언스 코오포레이션 비드-기초 서열화를 위한 시약, 방법, 및 라이브러리
EP2233582A1 (fr) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Sequencage nucléotidique comprenant des cycles sucessifs de fromation duplex
EP1846446B1 (fr) 2005-02-02 2013-06-26 Novo Nordisk A/S Derives d'insuline
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
EP1846447B1 (fr) 2005-02-02 2013-08-21 Novo Nordisk A/S Derives d'insuline
US7790363B2 (en) * 2005-02-07 2010-09-07 Abbott Laboratories Inc. Diagnostic test for vitamin B12
KR101379364B1 (ko) * 2005-02-08 2014-03-31 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 암 치료를 위한 mda-7을 포함하는 조성물
JP4859248B2 (ja) 2005-02-08 2012-01-25 リサーチ ディベロップメント ファウンデーション 可溶性Gタンパク質共役型レセプター(sGPCR)に関する組成物および方法
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006088445A2 (fr) * 2005-02-11 2006-08-24 Southern Illinois University Amorces metaboliques pour la detection de bacteries de diminution de perchlorate et leurs procedes d'utilisation
EP2505591A1 (fr) 2005-02-11 2012-10-03 Memorial Sloan-Kettering Cancer Center Procédés et compositions pour détecter un mutant d'EGFR résistant aux médicaments
CA2597945C (fr) 2005-02-17 2016-07-12 Biogen Idec Ma Inc. Traitement de troubles neurologiques
WO2006089152A2 (fr) * 2005-02-18 2006-08-24 Maxcyte, Inc. Utilisation d'inhibiteurs de methyltransferase pour augmenter l'expression transgenique
ES2385045T3 (es) 2005-02-18 2012-07-17 Novartis Vaccines And Diagnostics, Inc. Inmunógenos de Escherichia coli uropatogénica
HUE030881T2 (en) 2005-02-18 2017-06-28 Glaxosmithkline Biologicals Sa Meningitis / sepsis-associated escherichia coli proteins and nucleic acids
US8178291B2 (en) 2005-02-18 2012-05-15 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
US20090215028A1 (en) * 2005-02-18 2009-08-27 Ellen Paxinos Methods and Compositions for Determining Anti-HIV Drug Susceptibility and Replication Capacity of HIV
GB0503546D0 (en) * 2005-02-21 2005-03-30 Hellenic Pasteur Inst Antibody
EP1871402B1 (fr) 2005-02-25 2017-07-26 State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center Culture de cellules de grain de raisin pour le traitment de l'inflammation
WO2006090987A1 (fr) * 2005-02-28 2006-08-31 Bioquest, Inc. Methodes d'execution de reactions enzymatiques directes mettant en oeuvre des molecules d'acide nucleique
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) * 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
WO2006095941A1 (fr) 2005-03-05 2006-09-14 Seegene, Inc. Oligonucleotide a double specificite et processus l'utilisant
PL1856257T3 (pl) 2005-03-05 2012-03-30 Seegene Inc Procesy wykorzystujące oligonukleotyd o podwójnej specyficzności oraz oligonukleotyd o podwójnej specyficzności
US7794659B2 (en) 2005-03-10 2010-09-14 Gen-Probe Incorporated Signal measuring system having a movable signal measuring device
EP2886658A1 (fr) 2005-03-10 2015-06-24 BASF Enzymes LLC Enzymes de lyase, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation
JP5590697B2 (ja) 2005-03-11 2014-09-17 セレラ コーポレーション 冠動脈心疾患に関連する遺伝的多型、その検出方法および使用
BRPI0609140A2 (pt) 2005-03-15 2010-02-17 Verenium Corp celulases, ácidos nucléicos que codificam eles e métodos para a produção e uso deles
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
US7498136B2 (en) * 2005-03-18 2009-03-03 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of Neisseria
EP1865940B1 (fr) 2005-03-21 2013-02-13 Virobay, Inc. Composes alpha-cetoamide utilises en tant qu'inhibiteurs de cysteine protease
AU2006226861B2 (en) 2005-03-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Treatment of protein degradation disorders
US20070092886A1 (en) * 2005-03-22 2007-04-26 Raymond Tabibiazar Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
SI2567976T1 (sl) 2005-03-23 2017-11-30 Genmab A/S Protitelesa usmerjena proti cd38 za zdravljenje multiplega mieloma
JP2008534502A (ja) * 2005-03-24 2008-08-28 アバニール・ファーマシューティカルズ マクロファージ遊走阻止因子の阻害剤としてのチエノピリジノン誘導体
EP3058955B1 (fr) 2005-03-24 2019-05-29 Millennium Pharmaceuticals, Inc. Anticorps se liant à l'ov064 et leurs procédés d'utilisation
DK2343320T3 (da) 2005-03-25 2018-01-29 Gitr Inc Anti-gitr-antistoffer og anvendelser deraf
US20060257902A1 (en) * 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
US7964557B2 (en) * 2005-03-28 2011-06-21 University Of Louisville Research Foundation, Inc. Inhibition of wet type age related macular degeneration (AMD) by adiponectin or acrp 30
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
KR20140068234A (ko) 2005-03-31 2014-06-05 더 제너럴 하스피탈 코포레이션 Hgf/hgfr 활성의 모니터링 및 조정
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
US20060275798A1 (en) * 2005-04-04 2006-12-07 Steichen John C Detection of organisms using a media sachet and primer directed nucleic acid amplification
US20060246493A1 (en) * 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
EP2062591A1 (fr) 2005-04-07 2009-05-27 Novartis Vaccines and Diagnostics, Inc. CACNA1E pour la détection et le traitement de diagnostic du cancer
EP1871911A2 (fr) 2005-04-07 2008-01-02 Chiron Corporation Génes liés au cancer (prlr)
EP2386571B1 (fr) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
ES2374419T3 (es) 2005-04-11 2012-02-16 National Research Council Of Canada Identificación de una beta-1,3-n-acetilgalactosaminiltranferasa (cgte) de campylobacter jejuni lio87.
EP2333045B1 (fr) 2005-04-12 2016-11-09 Danisco US Inc. Mutants inactivés génétiques avec une production de protéine altérée
US20060228721A1 (en) * 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
WO2006108422A2 (fr) * 2005-04-12 2006-10-19 In Situ Rcp A/S Under Founding Procedes de production d'oligonucleotides
WO2006110855A2 (fr) 2005-04-12 2006-10-19 454 Life Sciences Corporation Procedes de determination de variantes de sequence utilisant un sequencage des amplicons
EP1871897B1 (fr) * 2005-04-12 2010-09-29 Olink AB Procédés de production d'oligonucléotides
CN103215351A (zh) 2005-04-13 2013-07-24 科学研究高等机关 鉴定用于癌症治疗的化合物的体外方法
SI2332909T1 (sl) 2005-04-13 2015-01-30 Astex Therapeutics Limited Derivati hidroksibenzamida in njih uporaba kot inhibitorji hsp90
WO2006113467A2 (fr) 2005-04-14 2006-10-26 The Trustees Of Boston University Diagnostic des troubles pulmonaires mettant en oeuvre la prediction de categories
US20090007301A1 (en) 2005-04-15 2009-01-01 Hsu-Ching Chen Wintz Plant Promoters, Terminators, Genes, Vectors and Related Transformed Plants
WO2006113559A2 (fr) 2005-04-15 2006-10-26 President And Fellows Of Harvard College Procede permettant de moduler la formation et la mineralisation osseuses par modulation de l'activite de krc
BRPI0609079A2 (pt) 2005-04-18 2010-11-16 Novo Nordisk As peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo
US20060253068A1 (en) * 2005-04-20 2006-11-09 Van Bilsen Paul Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
US11865172B2 (en) 2005-04-21 2024-01-09 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US7959929B2 (en) 2005-04-21 2011-06-14 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
BR122018012345B1 (pt) 2005-04-21 2021-10-26 University Of Florida Research Foundation, Inc. Vetor viral recombinante ou vetor de polinucleotídeo recombinante, e composição
MY148086A (en) 2005-04-29 2013-02-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
WO2006119292A2 (fr) * 2005-04-29 2006-11-09 Henkin, Robert Technique de detection de substances biologiques
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP1896610A2 (fr) * 2005-05-03 2008-03-12 Handylab, Inc. Granulés lyophilisés
UA95446C2 (ru) * 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
WO2006119466A2 (fr) * 2005-05-04 2006-11-09 Immunotrex Corporation Procedes de detection et d'identification de micro organismes
US7524660B2 (en) * 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
US7902352B2 (en) * 2005-05-06 2011-03-08 Medtronic, Inc. Isolated nucleic acid duplex for reducing huntington gene expression
EP1885854B1 (fr) * 2005-05-06 2012-10-17 Medtronic, Inc. Procedes et sequences permettant de supprimer l'expression du gene de huntington chez les primates
US8124335B2 (en) 2005-05-06 2012-02-28 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
US8329652B2 (en) * 2005-05-10 2012-12-11 Neoloch Aps Neuritogenic peptides
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US20060286584A1 (en) * 2005-05-12 2006-12-21 Board Of Regents, The University Of Texas System Compositions and methods for the regulation of cell proliferation and apoptosis
WO2006122401A1 (fr) * 2005-05-16 2006-11-23 Institut De Recherches Cliniques De Montreal/I.R.C.M. Regulation progressive de fonctions cellulaires au moyen de eat-2, d'un regulateur lie a sap exprime dans des cellules immunitaires innees
CA2608636C (fr) 2005-05-17 2015-02-10 Frank Koentgen Systeme de clonage sequentiel
US8124084B2 (en) 2005-05-17 2012-02-28 University Of Connecticut Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra
WO2006125065A2 (fr) * 2005-05-18 2006-11-23 The Board Of Trustees Operating Michigan State University Resistance aux pucerons du soya dans le materiel genetique du soya au debut de la maturation
DK1889065T3 (da) 2005-05-18 2013-09-02 Xoma Technology Ltd Metoder til diagnostisering og behandling af sygdomme med en autoimmun- og/eller inflammationskomponent
CA2601554A1 (fr) * 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Composes et procedes de marquage d'oligonucleotides
US7968697B2 (en) * 2005-05-25 2011-06-28 Chrontech Pharma Ab Hepatitis C virus non-structural NS3/4A fusion gene
US9943481B2 (en) 2005-05-26 2018-04-17 Biorest Ltd. Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
US20080293038A1 (en) * 2005-05-27 2008-11-27 Parkin Neil T Method for Determining Resistance of Hiv to Nucleoside Reverse Transcriptase Inhibitor Treatment
AP2693A (en) 2005-05-27 2013-07-16 Monsanto Technology Llc Soybean event MON89788 and methods for detection thereof
US20090130666A1 (en) * 2005-05-27 2009-05-21 Applera Corporation Cytometric system including nucleic acid sequence amplification, and method
EP1896618A4 (fr) 2005-05-27 2009-12-30 Monogram Biosciences Inc Procédés et compositions pour déterminer la résistance du vih-1 à des inhibiteurs de protéase
AU2006309284B2 (en) 2005-05-31 2012-08-02 Board Of Regents, The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US9506121B2 (en) 2005-06-06 2016-11-29 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to HIV entry inhibitors
US8071284B2 (en) 2005-06-06 2011-12-06 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs
CA2919210C (fr) 2005-06-07 2019-03-05 Luminex Corporation Methodes de detection et de typage d'acides nucleiques
WO2006135786A2 (fr) 2005-06-09 2006-12-21 Praecis Pharmaceuticals, Inc. Procedes de synthese de bibliotheques codees
SG162795A1 (en) 2005-06-15 2010-07-29 Callida Genomics Inc Single molecule arrays for genetic and chemical analysis
AU2005333512A1 (en) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
CN101243178A (zh) 2005-06-16 2008-08-13 特拉维夫大学拉莫特有限公司 用于治疗cns疾病的分离细胞和包含这种细胞的细胞群
BRPI0612301A2 (pt) * 2005-06-20 2009-01-27 Decode Genetics Ehf mÉtodo para diagnosticar uma suscetibilidade para a diabete tipo ii em um indivÍduo, kit, e, mÉtodo para avaliar um indivÍduo quanto a probabilidade de resposta a um agente terapÊutico de tcf7l2
US20060286006A1 (en) * 2005-06-21 2006-12-21 Mcdaniel C S Method and apparatus for the treatment of fluid waste streams
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US20110045991A1 (en) * 2005-06-23 2011-02-24 Sadanand Gite Methods for the Detection of Colorectal Cancer
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
CN101501055B (zh) * 2005-06-23 2016-05-11 贝勒医学院 负性免疫调节因子的调节和免疫疗法应用
EP2508867A1 (fr) * 2005-06-24 2012-10-10 Board Of Regents, The University Of Texas System Systemes et procedes faisant appel a des cartouches autonomes comprenant des systemes de detection et des systemes de distribution de fluides
US20080280843A1 (en) * 2006-05-24 2008-11-13 Van Bilsen Paul Methods and kits for linking polymorphic sequences to expanded repeat mutations
US7645866B2 (en) * 2005-06-28 2010-01-12 Life Technologies Corporation Methods of producing and sequencing modified polynucleotides
EP1896586A2 (fr) * 2005-06-28 2008-03-12 Medtronic, Inc. Procedes et sequences permettant de supprimer de maniere preferentielle l'expression de la huntingtine mutee
US9133517B2 (en) * 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US8067208B2 (en) 2005-06-30 2011-11-29 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using multidimensional probe analysis
DK1896073T3 (da) 2005-06-30 2013-06-03 Janssen Biotech Inc Anti-il-antistoffer, sammensætninger, fremgangsmåder og anvendelser
WO2007005613A2 (fr) * 2005-07-01 2007-01-11 Promega Corporation Reseau de particules flottantes destinees a purifier des biomolecules et utilisations de ces particules ou de ce reseau de particules flottantes pour purifier des biomolecules
AU2006269820B2 (en) 2005-07-07 2012-01-19 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
BRPI0612288A2 (pt) * 2005-07-07 2009-01-27 Danisco amilase modificada de pseudomonas saccharophilia
US8030050B2 (en) * 2005-07-07 2011-10-04 Danisco A/S Modified amylases from Pseudomonas species
EP1915448B1 (fr) * 2005-07-07 2013-09-04 Yissum Research Development Company, of The Hebrew University of Jerusalem Agents de type acide nucléique pour la régulation à la baisse de h19 et méthodes d'emploi desdits agents
US9051379B2 (en) 2005-07-07 2015-06-09 Fulcrum Sp Ltd. Sp1 polypeptides, modified Sp1 polypeptides and uses thereof
US8785130B2 (en) * 2005-07-07 2014-07-22 Bio-Id Diagnostic Inc. Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material
US20080242834A1 (en) * 2005-07-08 2008-10-02 Ohio University Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
WO2007011722A2 (fr) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Systeme de decouverte de reaction
EP1904638A2 (fr) 2005-07-18 2008-04-02 Metabogal Ltd. Administration mucosale ou enterale de macromolecules biologiquement actives
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
AU2006272776B2 (en) 2005-07-21 2012-01-19 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US20070026444A1 (en) * 2005-07-27 2007-02-01 Allan Heff Thermal cycling in polymerase chain reactions by thermodynamic methods
EP1748081A1 (fr) 2005-07-28 2007-01-31 Roche Diagnostics GmbH Procédé et dispositf d'analyse
AU2006276110A1 (en) 2005-07-29 2007-02-08 Monsanto Technology Llc Development of novel germplasm using segregates from transgenic crosses
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
US7892795B2 (en) 2005-08-02 2011-02-22 Focus Diagnostics, Inc. Methods and compositions for detecting BK virus
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
AU2006341615A1 (en) * 2005-08-03 2007-10-18 Fraunhofer Usa, Inc. Compositions and methods for production of immunoglobulins
AU2006278260B2 (en) * 2005-08-08 2012-03-08 Onconon, Llc. Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
CA2619841C (fr) * 2005-08-16 2012-07-03 Merlogen, Llc Methodes d'identification de mutations de merle dans le gene silv
JP5366546B2 (ja) 2005-08-16 2013-12-11 ノボ・ノルデイスク・エー/エス 成熟インスリンポリペプチドの作製方法
US7838646B2 (en) * 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US20070202512A1 (en) * 2005-08-19 2007-08-30 Bristol-Myers Squibb Company Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof
US9150850B2 (en) 2005-08-22 2015-10-06 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
WO2007023491A2 (fr) 2005-08-24 2007-03-01 Yeda Research And Development Co. Ltd. Cellules tolerogeniques derivees de donneurs universels et destinees a induire une tolerance a la transplantation non syngenique
WO2007022799A1 (fr) 2005-08-26 2007-03-01 Ares Trading S.A. Procede de preparation d'interferon beta glycosyle
DK2336362T3 (en) * 2005-08-26 2019-01-21 Dupont Nutrition Biosci Aps USE OF CRISPR-ASSOCIATED GENES (CAS)
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
EP3354723B1 (fr) 2005-08-29 2023-12-13 Technion Research & Development Foundation Ltd. Milieux de culture de cellules souches
JP4891580B2 (ja) * 2005-08-31 2012-03-07 株式会社東芝 不揮発性半導体記憶装置
WO2007028147A2 (fr) * 2005-09-01 2007-03-08 Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin Identification d'un gene specifique de neoplasie intraepitheliale prostatique (pin) et proteine (pin-1) utilisee comme traitement de diagnostic pour le cancer de la prostate
PL1937834T3 (pl) * 2005-09-01 2014-11-28 Mtpcr Pty Ltd Sposoby wzmacniania, kwantyfikacji i identyfikacji kwasów nukleinowych
WO2007030505A1 (fr) * 2005-09-06 2007-03-15 Gen-Probe Incorporated Procedes, compositions et necessaires pour l'amplification isotherme d'acides nucleiques
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
EP1929046B1 (fr) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Procedure d'amplication d'acide nucleique amelioree
WO2007030668A2 (fr) * 2005-09-07 2007-03-15 Jennerex Biotherapeutics Ulc Traitement systemique de cancers metastasiques et/ou systemiquement dissemines a l'aide de poxvirus exprimant le gm-csf
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US8193328B2 (en) * 2005-09-08 2012-06-05 Philadelphia Health & Education Corporation Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
EP1762627A1 (fr) * 2005-09-09 2007-03-14 Qiagen GmbH Procédé pour l'activation d'acides nucléiques pour effectuer une réaction d'une polymérase
CA2814598A1 (fr) 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Fusion geniques recurrentes dans le cancer de la prostate
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2007031559A2 (fr) 2005-09-14 2007-03-22 Novo Nordisk Health Care Ag Polypeptides du facteur vii de coagulation humain
US7608395B2 (en) 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
US20070065834A1 (en) * 2005-09-19 2007-03-22 Hillis William D Method and sequences for determinate nucleic acid hybridization
EP1926459B1 (fr) 2005-09-19 2015-01-07 Histogenics Corporation Matrice support de cellules dont la densite des pores et la porosite sont definies specifiquement de maniere uniforme verticalement et organisees de maniere non aleatoire, et procede de preparation de celle-ci
EP2372363A1 (fr) 2005-09-20 2011-10-05 OSI Pharmaceuticals, Inc. Marqueurs biologiques prédictifs d'une réaction anticancéreuse aux inhibiteurs kinase du récepteur du facteur de croissance 1 analogue à l'insuline
ATE466079T1 (de) 2005-09-22 2010-05-15 Yissum Res Dev Co Nukleinsäure konstrukten, pharmazeutische kompositionen und methoden für die behandlung von krebs
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
IL172297A (en) 2005-10-03 2016-03-31 Compugen Ltd Soluble vegfr-1 variants for the diagnosis of preeclampsia
US8093030B2 (en) 2005-10-06 2012-01-10 Lucigen Corporation Thermostable viral polymerases and methods of use
CA2625035A1 (fr) * 2005-10-06 2007-04-19 University Of Delaware Polynucleotides riches en guanidine pour le traitement de la maladie de huntington
DK2385141T3 (da) 2005-10-07 2013-10-28 Speedx Pty Ltd Flerkomponentnukleinsyreenzymer og fremgangsmåder til anvendelse heraf
EP2546360A1 (fr) 2005-10-07 2013-01-16 Callida Genomics, Inc. Réseaux de molécules simples auto-assemblées et leurs utilisations
WO2007044566A2 (fr) * 2005-10-07 2007-04-19 Baylor Research Institute Diagnostic d'une arthrite juvenile idiopathique avec debut systemique par analyse de puces a adn a base de leucocytes sanguins
US7838221B2 (en) 2005-10-11 2010-11-23 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
AR055444A1 (es) * 2005-10-12 2007-08-22 Procter & Gamble Uso y produccion de metalopretasa neutra estable al almacenamiento
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
EP2614836A3 (fr) * 2005-10-17 2013-10-23 MedImmune, LLC Virus de la grippe A réassorti et de croissance haute
AU2006304721B2 (en) 2005-10-17 2012-01-19 Gen-Probe Incorporated Compositions and methods to detect Legionella pneumophila nucleic acid
CN117587038A (zh) 2005-10-19 2024-02-23 佛罗里达大学研究基金公司 能够感染犬科动物的流感病毒及其用途
EP1777523A1 (fr) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthode pour pronostiquer la progression d'un cancer et les résultats du patient et les moyens pour performer la méthode
AU2006304797B2 (en) 2005-10-20 2013-01-31 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
WO2007049118A1 (fr) * 2005-10-25 2007-05-03 Council Of Scientific And Industrial Research Variantes génétiques de polyphosphate-4-phosphatase inositol humain, de type i (inpp4a) servant a la prediction et la therapie de troubles immunologiques
US8105775B2 (en) * 2005-10-25 2012-01-31 Interleukin Genetics, Inc. IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
UA96928C2 (ru) 2005-10-26 2011-12-26 Э.И. Дю Пон Де Немур Энд Компани Ферментативное продуцирование спиртов с четырьмя атомами углерода
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
US8956850B2 (en) 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
WO2007053358A2 (fr) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Procedes d'identification de composes etudies, par recours a des bibliotheques codees
MX2008005405A (es) * 2005-10-28 2008-09-11 Florida Internat University Bo Anticuerpos quimericos equinos: humanos.
EP2484202B1 (fr) 2005-10-28 2017-06-07 Dow AgroSciences LLC Nouveaux gènes résistant aux herbicides
SG169361A1 (en) 2005-11-01 2011-03-30 Abbott Biotech Ltd Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
EP2395012B8 (fr) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Molécules d'ARNsi modifiées et leurs utilisations
BRPI0618337A2 (pt) 2005-11-07 2016-09-13 Siemens Healthcare Diagnostics seqüências de oligonucleotídeos específicas para chlamydia trachomatis
EP1945263A4 (fr) * 2005-11-09 2012-09-26 Ontherix Inc Peptides thérapeutiques se liant aux métaux
US7662624B2 (en) * 2005-11-09 2010-02-16 Ontherix, Inc. Metal-binding therapeutic peptides
US7611893B2 (en) 2005-11-09 2009-11-03 Ontherix, Inc. Metal-binding therapeutic peptides
US20080039393A1 (en) * 2005-11-09 2008-02-14 Desmond Mascarenhas Metal-binding therapeutic peptides
EP1957115B8 (fr) 2005-11-10 2014-03-05 Celldex Therapeutics, Inc. Methode de traitement du cancer de l'ovaire et du rein utilisant des anticorps diriges contre l'antigene a domaine 1 de mucine et a domaine immunoglobuline des lymphocytes t (tim-1)
CA2629299C (fr) 2005-11-12 2017-08-22 The Board Of Trustees Of The Leland Stanford Junior University Methodes associees au fgf2 pour diagnostiquer et traiter une depression
WO2007120208A2 (fr) * 2005-11-14 2007-10-25 President And Fellows Of Harvard College Séquençage de l'adn en cercle tournant sur nanogrille
PL2380592T3 (pl) 2005-11-14 2018-07-31 Teva Pharmaceuticals International Gmbh Przeciwciało antagonistyczne skierowane przeciwko peptydowi powiązanemu z genem kalcytoniny
WO2007059423A2 (fr) * 2005-11-14 2007-05-24 Siemens Healthcare Diagnostics Inc. Puces de detection a guide d'ondes planaire et chambres servant a realiser des dosages de pcr multiplexes
US8936945B2 (en) * 2005-11-17 2015-01-20 The Regents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
US20080280328A1 (en) 2005-11-18 2008-11-13 Novozymes A/S Glucoamylase Variants
US20090170090A1 (en) * 2005-11-18 2009-07-02 Bioline Limited Method for Enhancing Enzymatic DNA Polymerase Reactions
GB2432366B (en) * 2005-11-19 2007-11-21 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
EP1957541A2 (fr) * 2005-11-21 2008-08-20 Laboratoires Serono SA Compositions et methodes de production de molecules hybrides de fixant a des antigenes, et leurs utilisations
EP1969137B1 (fr) 2005-11-22 2011-10-05 Stichting Dienst Landbouwkundig Onderzoek Detection multiplexe d'acides nucleiques
US20090068643A1 (en) * 2005-11-23 2009-03-12 Integrated Dna Technologies, Inc. Dual Function Primers for Amplifying DNA and Methods of Use
BRPI0620552A2 (pt) 2005-11-23 2011-11-22 Du Pont polinucleotìdeo isolado, polipeptìdeo delta-9 elongase, construção recombinante, célula vegetal, método para transformar uma célula, método para produção de uma planta transgênica, sementes transgênicas, método para fabricar ácidos graxos poliinsaturados de cadeia longa, óleos, método para produzir pelo menos um ácido graxo poliinsaturado, plantas de semente oleaginosa, sementes, alimentos, fragmento de ácido nucléico isolado e progênies de plantas
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
FR2902430B1 (fr) * 2005-11-25 2012-11-02 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence des genes h5 et n1 du virus d'influenza a
US7579005B2 (en) * 2005-11-28 2009-08-25 E. I. Du Pont De Nemours And Company Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
DK2463388T3 (en) 2005-11-29 2018-02-26 Cambridge Entpr Ltd Markers for breast cancer
ES2409128T3 (es) 2005-11-29 2013-06-25 Gamida Cell Ltd. Procedimientos de mejora de anidamiento e injerto de células madre
EP2289909B1 (fr) 2005-11-30 2014-10-29 AbbVie Inc. Procédé de dépistage, procédé de purification d'oligomères béta non-diffusibles, anticorps sélectifs contre les susdits béta-oligomères non diffusibles, et procédé pour la préparation des susdits anticorps
US20070237716A1 (en) * 2005-11-30 2007-10-11 Mason Andrew L Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr) of human b-retrovirus
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
WO2007065926A1 (fr) * 2005-12-07 2007-06-14 Tibotec Pharmaceuticals Ltd. Procédés, vecteurs de type plasmides et amorces servant à évaluer la valeur adaptative virale du vih
US8110194B2 (en) 2005-12-07 2012-02-07 Medarex, Inc. CTLA-4 antibody dosage escalation regimens
CN102016050A (zh) * 2005-12-09 2011-04-13 金克克国际有限公司 用于去污的酰基转移酶
US8030034B2 (en) 2005-12-09 2011-10-04 Promega Corporation Nucleic acid purification with a binding matrix
US20090305248A1 (en) * 2005-12-15 2009-12-10 Lander Eric G Methods for increasing accuracy of nucleic acid sequencing
EP2674440B1 (fr) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Ensembles bioactifs à base d'immunoglobuline multivalent
EP1798292A1 (fr) 2005-12-19 2007-06-20 Nutreco Nederland B.V. Procédé pour augmenter la production de viande de dindon
EP1798542A1 (fr) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Procédé et appareil analytiques
EP1798650A1 (fr) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Procédé analytique et instrument
US8313901B2 (en) * 2005-12-21 2012-11-20 Yale University Methods and compositions related to the modulation of riboswitches
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
CA2638903A1 (fr) 2005-12-23 2007-07-05 Siemens Healthcare Diagnostics Inc. Methodes et reactifs destines a un genotypage de vhc
JP4808785B2 (ja) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー/エス インスリン組成物および組成物の製造方法
EP1976567B1 (fr) * 2005-12-28 2020-05-13 The Scripps Research Institute Utilisation de transcrits d'arn antisens et non codants naturels comme cibles de médicaments
SI3219328T1 (sl) 2005-12-29 2020-10-30 Janssen Biotech, Inc. Človeška protitelesa proti-IL-23, sestavki, postopki in uporabe
US20070186298A1 (en) * 2006-01-04 2007-08-09 Blowe Charlotte D Follistatin gene as a genetic marker for reproductive and performance traits in pigs
US20080118914A1 (en) * 2006-01-04 2008-05-22 Charlotte Dawn Blowe Follistatin gene as a genetic marker for first parity litter size in pigs
EP1989318B1 (fr) 2006-01-06 2014-07-30 Agilent Technologies, Inc. Composition tampon de reaction pour replication d'acide nucleique au moyen de polymerases adn integrees
GB0600228D0 (en) 2006-01-06 2006-02-15 Fermentas Uab Inactivation method
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
EP1981910B1 (fr) 2006-01-13 2013-06-26 A Chan Holding B.V. Méthode d'identification d'un inhibiteur de l'interaction entre le glypican et la sclerostine
US8775526B2 (en) 2006-01-16 2014-07-08 Zlango Ltd. Iconic communication
CA2637267A1 (fr) 2006-01-16 2007-07-19 Compugen Ltd. Nouvelles sequences de nucleotides et d'acides amines et leurs procedes d'utilisation pour le diagnostic
AU2007207544A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
AU2007282135C1 (en) 2006-01-18 2012-05-24 Coimmune, Inc. Systems and methods for processing samples in a closed container, and related devices
EP2368569A3 (fr) 2006-01-18 2012-05-02 University Of Chicago Compositions et procédés liés aux protéines des bactéries staphylocoques
CA2637203A1 (fr) * 2006-01-19 2007-07-26 Monogram Biosciences, Inc. Procedes permettant de determiner la resistance du vih aux traitements par un inhibiteur de protease
EP2363711A1 (fr) 2006-01-27 2011-09-07 Tripath Imaging, Inc. Méthodes permettant d'identifier des patientes présentant un risque accru d'être atteintes d'un cancer de l'ovaire et compositions associées
JP2009525032A (ja) 2006-02-02 2009-07-09 コーベット ライフ サイエンス プロプライエタリー リミテッド サーモサイクラーおよびサンプルポート
WO2007092314A2 (fr) 2006-02-02 2007-08-16 Verenium Corporation Estérases, acides nucléiques apparentés et procédés associés
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US7553941B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20090197286A1 (en) 2006-02-06 2009-08-06 Rappaport Family Institute For Research In The Med Methods and Kit for Diagnosing T1DM
WO2007092538A2 (fr) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Procédés de confection de sondes nucléotidiques pour séquençage et synthèse
CA2641851A1 (fr) 2006-02-08 2007-08-16 Eric Hans Vermaas Procede de sequencage d'une matrice polynucleotidique
WO2007092944A2 (fr) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions et procedes impliquant une therapie de gene et une modulation de proteasome
DK2450439T3 (da) 2006-02-10 2014-02-10 Verenium Corp Cellulosenedbrydende enzymer, nucleinsyrer, der koder for dem, og fremgangsmåder til at fremstille og benytte dem
US20070190828A1 (en) * 2006-02-10 2007-08-16 Bio-Rad Laboratories, Inc. Method for substantially preventing contamination of electrical contacts
WO2008048344A2 (fr) * 2006-02-13 2008-04-24 Fraunhofer Usa, Inc. Antigènes de bacillus anthracis, compositions pour vaccins et procédés connexes
EP3561071B1 (fr) 2006-02-13 2020-12-16 Fluidigm Canada Inc. Analyses d'expression génique effectuées par analyse élémentaire
US8222423B2 (en) * 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
US8043839B2 (en) 2006-02-14 2011-10-25 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
EP2412726B1 (fr) 2006-02-14 2016-06-15 University Of Tasmania Through The Menzies Research Institute Fragments de peptides dérivés de la métallothionéine
US20090221072A1 (en) * 2006-02-15 2009-09-03 Chen Thomas T Compositions and methods for modulating cell differentiation
CN107446033B (zh) 2006-02-22 2022-04-01 朱正崙 发育相关疾病的治疗
ES2387955T3 (es) 2006-02-27 2012-10-04 Novo Nordisk A/S Derivados de insulina
JP5022383B2 (ja) * 2006-02-27 2012-09-12 エフ.ホフマン−ラ ロシュ アーゲー マグネシウム封鎖によるpcrホットスタート
ES2548222T3 (es) 2006-02-28 2015-10-14 Montana State University Uso de derivados de fenantridio para diferenciar entre células intactas y con membrana comprometida usando técnicas moleculares a base de ácido nucleico
WO2007100919A2 (fr) * 2006-03-01 2007-09-07 Perlegen Sciences, Inc. Marqueurs pour l'accoutumance
US20110143344A1 (en) * 2006-03-01 2011-06-16 The Washington University Genetic polymorphisms and substance dependence
JP5107943B2 (ja) 2006-03-06 2012-12-26 ゼティク テクノロジーズ リミテッド 細胞の表現型を特定するための方法および組成物
KR101622894B1 (ko) 2006-03-07 2016-05-19 바스프 엔자임스 엘엘씨 알돌라제, 이것을 코딩하는 핵산과 그 제조 방법 및 사용 방법
CN101437954B (zh) 2006-03-07 2015-09-09 嘉吉公司 醛缩酶和编码醛缩酶的核酸以及它们的制备和使用方法
WO2007103541A2 (fr) 2006-03-09 2007-09-13 The Trustees Of Boston University Méthodes de diagnostic et de pronostic pour troubles des poumons utilisant des profils d'expression de gènes de cellules épithéliales nasales
ES2392103T3 (es) 2006-03-13 2012-12-04 Novovacs Holding B.V. Vacuna contra el cáncer
US20090061450A1 (en) * 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
WO2007106580A2 (fr) 2006-03-15 2007-09-20 Micronics, Inc. Tests de flux magnetique rapide
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
GB0605689D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
ES2537641T3 (es) 2006-03-23 2015-06-10 Pluristem Ltd. Métodos de expansión celular y usos de células y medios acondicionados producidos de este modo para terapia
EP2004221A2 (fr) 2006-03-23 2008-12-24 Novartis Pharma AG Thérapeutique anticorps antigène de cellules anti-tumorales
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
EP2004858A4 (fr) 2006-03-28 2009-12-09 Tel Hashomer Medical Res Infrastructure & Services Ltd Procedes et kits pour determiner la predisposition a la resistance a la warfarine
JP2009531464A (ja) 2006-03-29 2009-09-03 メリアル リミテッド 連鎖球菌に対するワクチン
WO2007126975A2 (fr) 2006-03-31 2007-11-08 The Govt. Of The Usa, As Represented By The Secretary, Dept. Of Health & Human Services, Bactérie nouvellement découverte dans la famille des acetobacteraceae
US7537917B2 (en) * 2006-03-31 2009-05-26 Collins Michael J Microwave assisted PCR amplification of DNA
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
US9182398B2 (en) * 2006-04-01 2015-11-10 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
WO2007113622A2 (fr) * 2006-04-04 2007-10-11 Labonnet Ltd. Evaluation de la compatibilite des cinetiques de reaction entre des reactions d'amplification en chaine par polymerase
US7741469B2 (en) * 2006-04-05 2010-06-22 University Of Iowa Research Foundation Compositions for treating hearing loss and methods of use thereof
US7285388B1 (en) * 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
CA2648580A1 (fr) * 2006-04-07 2008-05-02 Xdx, Inc. Expression d'acide nucleique en reponse aux steroides et prevision de l'activite d'une maladie
EP2010226B1 (fr) 2006-04-07 2014-01-15 The Research Foundation of State University of New York Polypeptides du récepteur de la transcobalamine, acides nucléiques et modulateurs associés, procédés d'utilisation associés destinés à moduler la croissance cellulaire et à traiter le cancer et la déficience en cobalamine
JP2009533023A (ja) 2006-04-07 2009-09-17 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド ナイセリア・ゴノレー(Neisseriagonorrhoeae)特異的オリゴヌクレオチド配列
US20070264694A1 (en) * 2006-04-07 2007-11-15 Eragen Biosciences, Inc. Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis
EP2010567A2 (fr) * 2006-04-07 2009-01-07 The Government of the United States of America as Represented by The Department of Health and Human Services Compositions d'anticorps et méthodes de traitement d'une maladie néoplasique
US20070238093A1 (en) * 2006-04-11 2007-10-11 Espy Mark J Detection of influenza A virus
US20070238095A1 (en) * 2006-04-11 2007-10-11 Mayo Foundation For Medical Education And Research , A Minnesota Corporation Detection of Influenza A Virus
WO2007124327A2 (fr) 2006-04-19 2007-11-01 Medimmune Llc. Méthodes et compositions d'expression d'arn viral sens négatif dans des cellules canines
CA2649725A1 (fr) * 2006-04-19 2007-10-25 Applera Corporation Reactifs, procedes et bibliotheques concus pour un sequencage a base de spheres sans gel
EP2029799B1 (fr) 2006-04-20 2012-08-22 Becton, Dickinson and Company Protéines thermostables et procédés pour les préparer et les utiliser
US7465793B2 (en) 2006-04-20 2008-12-16 E.I. Du Pont De Nemours And Company Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
CA2646309C (fr) 2006-04-21 2016-07-26 Nanobiosym, Inc. Plate-forme a molecules simples pour la decouverte de medicaments: procedes et appareils pour la decouverte de medicaments, comprenant des agents anticancereux et antiviraux
WO2007124152A2 (fr) 2006-04-21 2007-11-01 Senomyx, Inc. Compositions comestibles comprenant des composes aromatisants a gout sale a potentiel eleve et leurs procedes de production
US8492097B2 (en) 2006-04-24 2013-07-23 Diagnostic Hybrids, Inc. Compositions and methods for human metapneumovirus monoclonal antibodies
WO2007123386A1 (fr) 2006-04-24 2007-11-01 Sigma Alimentos, S.A. De C.V. Procédé de détection et de quantification multiple et simultanée de pathogènes par réaction en chaîne par polymérase en temps réel
WO2007125321A2 (fr) 2006-04-25 2007-11-08 Astex Therapeutics Limited Composés pharmaceutiques
FR2900158A1 (fr) 2006-04-25 2007-10-26 Biomerieux Sa Nouvelle sonde de detection agissant par reconnaissance moleculaire
US8933209B2 (en) * 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
US20070256148A1 (en) * 2006-04-26 2007-11-01 Katz David A DEP2 and its uses in major depressive disorder and other related disorders
US7951819B2 (en) 2006-04-26 2011-05-31 Cancer Research Technology Limited Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
WO2007127999A2 (fr) * 2006-04-28 2007-11-08 Igor Kutyavin Utilisation de produits d'amplification pcr portant des éléments de structure secondaire pour améliorer la détection d'acides nucléiques par pcr
US8298818B2 (en) * 2006-04-28 2012-10-30 University Of Florida Research Foundation, Inc. Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
CA2650820C (fr) 2006-04-28 2014-09-16 Igor Kutyavin Utilisation de desoxynucleoside triphosphates a base modifiee pour la detection d'acides nucleiques
US8900828B2 (en) * 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
WO2007130429A2 (fr) * 2006-05-03 2007-11-15 The President And Fellows Of Harvard College Inhibiteurs d'histone désacétylases et de tubuline désacétylases
BRPI0712041A2 (pt) 2006-05-09 2011-12-27 Novo Nordisk As derivado de insulina
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
EP2530168B1 (fr) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Dispositifs microfluidiques
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2016199A4 (fr) * 2006-05-11 2009-12-30 Geneohm Sciences Inc Procédés de détection à 100 % de l'identité d'une séquence pour divers génomes
CA2651946A1 (fr) * 2006-05-12 2007-11-22 Gen-Probe Incorporated Compositions et procedes servant a detecter l'acide nucleique d'enterocoques
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
EP2029157A4 (fr) * 2006-05-19 2009-11-18 Georgia Tech Res Inst Ligand des transporteurs abc
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
WO2007137300A2 (fr) 2006-05-23 2007-11-29 Bellicum Pharmaceuticals, Inc. Cellules dendritiques modifiées à survie et immunogénicité améliorées et compositions et procédés connexes
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
WO2007135182A2 (fr) 2006-05-24 2007-11-29 Novo Nordisk Health Care Ag Analogues et dérivés du facteur ix à temps d'action prolongé
EP2455490A3 (fr) 2006-05-25 2012-07-11 Monsanto Technology LLC Procédé pour identifier des locus de traits quantitatifs résistants aux maladies dans le soja et compositions correspondantes
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
MX284139B (es) 2006-05-26 2011-02-18 Amyris Biotechnologies Inc Produccion de isoprenoides.
WO2007140256A1 (fr) 2006-05-26 2007-12-06 Monsanto Technology, Llc Plant et semence de maïs correspondant au produit transgénique mon89034, procédés de détection et utilisation associés
EP1862538A1 (fr) * 2006-05-29 2007-12-05 IMBA-Institut für Molekulare Biotechnologie GmbH siRNA kinase et son utilisation
US20080125333A1 (en) * 2006-05-31 2008-05-29 Antara Biosciences Inc. Devices and kits for detecting one or more target agents
US8679741B2 (en) * 2006-05-31 2014-03-25 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
JP5558811B2 (ja) 2006-06-01 2014-07-23 トリリンク バイオテクノロジーズ 核酸増幅のための化学的に修飾されたオリゴヌクレオチドプライマー
US7479550B2 (en) * 2006-06-02 2009-01-20 The Board Of Regents Of The University Of Texas System Amyloid β gene vaccines
KR100785017B1 (ko) 2006-06-05 2007-12-12 삼성전자주식회사 혈액으로부터 핵산을 증폭하는 방법
WO2007140599A1 (fr) 2006-06-05 2007-12-13 Cancer Care Ontario Évaluation de risque pour cancer colorectal
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish
DK2017356T3 (da) 2006-06-06 2012-01-30 Gen Probe Inc Mærkede oligonukleotider og anvendelse deraf i fremgangsmåder til amplifikation af nukleinsyrer
SG172684A1 (en) * 2006-06-07 2011-07-28 Bioalliance Cv Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
US20080004185A1 (en) * 2006-06-12 2008-01-03 Antara Biosciences Inc. Three dimensional array
EP2029779A4 (fr) 2006-06-14 2010-01-20 Living Microsystems Inc Utilisation de génotypage snp fortement parallèle pour diagnostic fétal
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
WO2007146443A2 (fr) * 2006-06-14 2007-12-21 Oldenburg Kevin R Ph D dispositifs de cyclage thermique et procédés d'utilisation de ceux-ci
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
KR20090019895A (ko) * 2006-06-19 2009-02-25 대니스코 에이/에스 폴리펩티드
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US20080038163A1 (en) 2006-06-23 2008-02-14 Applera Corporation Systems and Methods for Cooling in Biological Analysis Instruments
CN101473036B (zh) * 2006-06-23 2012-12-12 丹尼斯科美国公司 利用用于工程改造多种性质的位点评价文库对序列和活性关系进行系统评价
US7951995B2 (en) 2006-06-28 2011-05-31 Pioneer Hi-Bred International, Inc. Soybean event 3560.4.3.5 and compositions and methods for the identification and detection thereof
US9150906B2 (en) 2006-06-28 2015-10-06 Bio-Id Diagnostic Inc. Determination of variants produced upon replication or transcription of nucleic acid sequences
CN101479293A (zh) 2006-06-29 2009-07-08 诺华有限公司 脑膜炎奈瑟球菌多肽
US7642049B2 (en) * 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
KR100790880B1 (ko) * 2006-07-05 2008-01-02 삼성전자주식회사 자성 비드가 결합되어 있는 소수성 다공성 중합체가 벽면에결합되어 있는 마이크로채널 또는 마이크로챔버를포함하는 미세유동장치 및 그를 이용하는 방법
US7972786B2 (en) * 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
EP1878803A1 (fr) * 2006-07-10 2008-01-16 Wageningen Universiteit Méthodes pour la détection des nématodes à galle
US20080026394A1 (en) * 2006-07-11 2008-01-31 Antara Biosciences Inc. Methods of detecting one or more cancer markers
AU2007314477B2 (en) 2006-07-11 2012-03-29 Rutgers, The State University Of New Jersey MG53 compositions and methods of use
US7977535B2 (en) 2006-07-12 2011-07-12 Board Of Trustees Of Michigan State University DNA encoding ring zinc-finger protein and the use of the DNA in vectors and bacteria and in plants
US20080038742A1 (en) * 2006-07-14 2008-02-14 Porter Tom E Genetic polymorphisms associated with body fat
US8324158B2 (en) * 2006-07-14 2012-12-04 Georgia Tech Research Corporation Methods for inhibiting CLC-2 channel with GATX2
JP2009543862A (ja) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ガンのバイオマーカーおよびその使用方法
EP1886727A1 (fr) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Dispositif pour analyse
WO2008011004A2 (fr) 2006-07-17 2008-01-24 Brandeis University Oligonucléotides spécialisés et leur utilisation pour l'amplification et la détection d'acides nucléiques
CA2658396C (fr) * 2006-07-18 2019-07-16 Danisco Us, Inc., Genencor Division Variantes de proteases actives sur une large plage de temperatures
EP2046109A4 (fr) 2006-07-20 2010-01-06 Yeda Res & Dev Organismes photosynthetiques, compositions et procedes de generation desdits organismes
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US20080027505A1 (en) * 2006-07-26 2008-01-31 G&L Consulting, Llc System and method for treatment of headaches
US7700756B2 (en) * 2006-07-27 2010-04-20 Southern Illinois University Metabolic primers for the detection of perchlorate-reducing bacteria and methods of use thereof
CA2658952A1 (fr) 2006-07-27 2008-01-31 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recepteur cellulaire du facteur antiproliferation
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US7566558B2 (en) * 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
EP3159417B1 (fr) 2006-08-01 2021-10-06 Gen-Probe Incorporated Procédés de capture de cible non spécifique d'acides nucléiques
EP2444413A1 (fr) 2006-08-04 2012-04-25 Verenium Corporation Procédé pour forage de puits de pétrole ou de gaz, injection et/ou fracturation
EP3536396B1 (fr) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
CA2660286A1 (fr) 2006-08-09 2008-02-21 Homestead Clinical Corporation Proteines specifiques d'organes et procedes d'utilisation
US20080039415A1 (en) * 2006-08-11 2008-02-14 Gregory Robert Stewart Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
WO2008021431A2 (fr) * 2006-08-14 2008-02-21 Xdx, Inc. Méthodes et compositions permettant de diagnostiquer et de surveiller l'état de rejet de greffe et de troubles immunitaires
AU2007285484B2 (en) 2006-08-16 2013-05-02 Novartis Ag Immunogens from uropathogenic Escherichia coli
WO2008105814A2 (fr) 2006-08-22 2008-09-04 Los Alamos National Security, Llc Dispositif à écoulement latéral miniaturisé pour détection rapide et sensible de protéines ou d'acides nucléiques
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
US20080047835A1 (en) * 2006-08-22 2008-02-28 Macconnell William P Genomic DNA Purifier
WO2008024294A2 (fr) 2006-08-24 2008-02-28 E. I. Du Pont De Nemours And Company Séquences diagnostiques pour pathogènes de crevettes
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
CN101611155B (zh) * 2006-08-24 2013-05-15 纳幕尔杜邦公司 虾病原体诊断用序列
WO2008024293A1 (fr) * 2006-08-24 2008-02-28 E. I. Du Pont De Nemours And Company Séquences diagnostiques pour pathogènes de crevettes
US8809052B2 (en) 2006-08-28 2014-08-19 Yeda Research And Development Co. Ltd. Methods of generating mature oligodendrocytes
WO2008027558A2 (fr) 2006-08-31 2008-03-06 Codon Devices, Inc. Assemblage itératif d'acides nucléiques utilisant l'activation de caractères codés par vecteurs
US20080057079A1 (en) * 2006-08-31 2008-03-06 Baylor Research Institute JC Virus Vaccine
WO2008033866A2 (fr) * 2006-09-11 2008-03-20 Yale University Riborégulateurs lysine, mise au point d'un composé structural présentant des riborégulateurs lysine, et méthodes d'utilisation et compositions utilisables avec des riborégulateurs lysine
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
WO2008033936A2 (fr) 2006-09-12 2008-03-20 Sierra Molecular Corporation Elimination d'interferences sur des dosages moleculaires d'acides nucleiques mettant en œuvre des solutions tamponnees de chaotropes
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
WO2008143627A2 (fr) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Procédé d'amplification ciblée de génome entier pour l'identification d'agents pathogènes
CN105769931B (zh) 2006-09-15 2021-04-27 渥太华医院研究机构 溶瘤弹状病毒
WO2008034121A2 (fr) * 2006-09-16 2008-03-20 Board Of Regents, The University Of Texas System Vaccin contre les parasites
WO2008048410A2 (fr) * 2006-09-19 2008-04-24 Human Biomolecular Research Institute Procédés diagnostiques et marqueurs génétiques pour la maladie d'alzheimer
EP2487240B1 (fr) 2006-09-19 2016-11-16 Interpace Diagnostics, LLC Micro ARN différemment exprimés dans des maladies pancréatiques et leurs utilisations
EP2617818B1 (fr) 2006-09-21 2016-03-23 BASF Enzymes LLC Phytases, acides nucléiques encodant celles-ci et méthodes pour leur fabrication et leur utilisation
CA2663001A1 (fr) 2006-09-21 2008-03-27 Verenium Corporation Phospholipases, acides nucleiques codant pour elles et leurs methodes d'obtention et d'utilisation
CA2700360A1 (fr) * 2006-09-22 2008-03-27 Baylor Research Institute Transformation in vivo de cellules acinaires pancreatiques en cellules produisant de l'insuline
US8680235B2 (en) * 2006-09-22 2014-03-25 Stowers Institute For Medical Research Branchiostoma derived fluorescent proteins
WO2008037735A1 (fr) 2006-09-27 2008-04-03 Novo Nordisk A/S Procédé de fabrication de polypeptides d'insuline mature
EP2083846B1 (fr) 2006-09-28 2015-07-15 Hepacore Ltd. Variantes fgf n-terminal à sélectivité de récepteur améliorée et ses utilisations
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
WO2008042436A2 (fr) 2006-10-03 2008-04-10 Biogen Idec Ma Inc. Biomarqueurs et essais pour le traitement du cancer
EP2099467B1 (fr) 2006-10-03 2017-05-10 University Of Medicine And Dentistry Of New Jersey Peptides atap, acides nucléiques le codant et procédés d'utilisation correspondants
US7888059B2 (en) * 2006-10-05 2011-02-15 Yeda Research And Development Co. Ltd. Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same
CN101595251B (zh) 2006-10-05 2014-06-11 技术研究及发展基金有限公司 微管及其制备方法
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
CN101600808B (zh) * 2006-10-06 2014-07-09 强生研究有限公司 分子开关及其使用方法
EP1914303A1 (fr) * 2006-10-09 2008-04-23 Qiagen GmbH ADN polymerases de Thermus eggertssonii
US20080260678A1 (en) * 2006-10-10 2008-10-23 University Of Colorado Molecular band-aid
WO2008045505A2 (fr) 2006-10-10 2008-04-17 Xenomics, Inc. Compositions, procédés et trousses pour isoler acides nucléiques à partir de fluides corporels au moyen d'un milieu d'échange anionique
US20080149655A1 (en) * 2006-10-11 2008-06-26 Imi Cornelius Inc. Variable capacity refrigeration system
EP2073807A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
EP2073803B1 (fr) 2006-10-12 2018-09-19 Astex Therapeutics Limited Combinaisons pharmaceutiques
ES2531372T3 (es) 2006-10-13 2015-03-13 Novo Nordisk Healthcare Ag Enzimas de procesamiento fusionadas a marcadores de proteínas básicas
US8158356B2 (en) * 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
US20080206758A1 (en) * 2006-10-17 2008-08-28 Lcm Technologies, Inc. Polynucleic acid-attached particles and their use in genomic analysis
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US7777877B2 (en) * 2006-10-20 2010-08-17 California Institute Of Technology High efficiency coupling optics for pumping and detection of fluorescence
US7709203B2 (en) 2006-10-20 2010-05-04 E.I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
CA2915679C (fr) 2006-10-20 2017-12-12 Celera Corporation Polymorphismes genetiques associes a la thrombose veineuse, procedes pour les detecter et utilisations
WO2008051491A2 (fr) 2006-10-20 2008-05-02 Danisco Us, Inc. Genencor Division Polyol oxydases
BRPI0717474A2 (pt) 2006-10-20 2014-03-11 Arizona Board Of Regentes For And On Behalf Of Arizona State University Cianobactéria modificada
WO2008063340A2 (fr) 2006-10-23 2008-05-29 E.I. Du Pont De Nemours And Company Delta-8 désaturases et utilisation de ces dernières dans la préparation d'acides gras polyinsaturés
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のsiRNAおよびその使用方法
EP2078089B1 (fr) 2006-10-31 2016-05-04 E. I. du Pont de Nemours and Company Événement de soja dp-305423-1, leurs compositions et leurs procédés d'identification et/ou de détection
US20080124768A1 (en) * 2006-10-31 2008-05-29 Sigma Aldrich Co. Methods and Compositions for Amplification of DNA
MX2009004870A (es) * 2006-11-02 2009-10-08 Veridex Llc Formacion de imagenes de endotelio vascular activado usando agentes de contraste inmunomagneticos, para la formacion de imagenes de resonancia magnetica.
AU2007325931A1 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
WO2008100352A2 (fr) 2006-11-03 2008-08-21 Baylor Research Institute Diagnostic de melanome metastatique et surveillance d'indicateurs d'immunosuppression par analyse de microreseaux de leucocytes sanguins
KR100803055B1 (ko) * 2006-11-03 2008-02-18 한국과학기술원 구면베어링 조립체의 제조장치 및 그 제조방법
US9375440B2 (en) * 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US8148067B2 (en) 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
WO2008061165A2 (fr) 2006-11-14 2008-05-22 Handylab, Inc. Cartouche microfluidique et son procédé de fabrication
CA2669131A1 (fr) 2006-11-15 2008-05-22 The University Of British Columbia Polymorphismes predictifs de la cardiotoxicite induite par l'anthracycline
EP2508623B1 (fr) 2006-11-20 2015-08-12 The Johns Hopkins University Marqueurs de méthylation de l'ADN et leurs méthodes d'utilisation
US7988668B2 (en) * 2006-11-21 2011-08-02 Medtronic, Inc. Microsyringe for pre-packaged delivery of pharmaceuticals
US7819842B2 (en) * 2006-11-21 2010-10-26 Medtronic, Inc. Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
CA2670967C (fr) 2006-11-29 2016-05-10 University Of Iowa Research Foundation Voies d'export alternatives pour l'interference d'arn exprimee par vecteur
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
CA2671264C (fr) 2006-11-30 2015-11-24 Research Development Foundation Bibliotheques d'immunoglobulines ameliorees
US7655403B2 (en) * 2006-12-02 2010-02-02 Texas Scottish Rite Hospital For Children CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis
US7902345B2 (en) * 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
BRPI0720226B8 (pt) 2006-12-07 2022-06-28 Dow Agrosciences Llc "vetor e métodos de seleção para uma célula de planta compreendendo um polinucleotídeo que codifica uma proteína que tem atividade de fosfinotricina acetil transferase, de uso de um gene de resistência a fosfinotricina como um marcador de resistência em células de planta, para geração de células de planta, plantas, e seus propagados resistentes à fosfinotricina, e de controle de pelo menos uma erva daninha em um campo".
EP2104734A2 (fr) * 2006-12-08 2009-09-30 Asuragen, INC. Gènes et voies génétiques régulés par le mir-20 en tant que cibles en vue d'une intervention thérapeutique
UA108733C2 (uk) 2006-12-12 2015-06-10 Толерантна до гербіциду рослина соняшника
JP5492563B2 (ja) 2006-12-12 2014-05-14 バイオレクシス ファーマシューティカル コーポレーション トランスフェリン融合タンパク質ライブラリー
EP2857526B1 (fr) * 2006-12-13 2016-08-17 Luminex Corporation Systèmes et procédés pour analyse multiplex de PCR en temps réel
US7972828B2 (en) * 2006-12-19 2011-07-05 Sigma-Aldrich Co. Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent
EP2118311B1 (fr) 2006-12-19 2013-07-03 GeneOhm Sciences, Inc. Detection de staphylococus aureus et identification de staphylococus aureus resistant a la methicilline
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
EP2383345B1 (fr) 2006-12-20 2017-11-22 Evogene Ltd. Polynucléotides et polypeptides impliqués dans le développement de fibres végétales et procédés d'utilisation
MX2009006782A (es) 2006-12-21 2009-09-21 Verenium Corp Amilasas y glucoamilasas, acidos nucleicos que las codifican y metodos para formarlas y usarlas.
JP5340167B2 (ja) 2006-12-21 2013-11-13 ジェン−プロウブ インコーポレイテッド 核酸増幅のための方法および組成物
EP2114941B1 (fr) * 2006-12-22 2015-03-25 Astex Therapeutics Limited Composés hétérocycliques bicycliques servant d'inhibiteurs des fgfr
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8513276B2 (en) 2006-12-22 2013-08-20 Astex Therapeutics Limited Imidazo[1,2-a]pyridine compounds for use in treating cancer
EP1939303A1 (fr) 2006-12-27 2008-07-02 Wageningen Universiteit Méthode pour la détection de nématodes
US8535888B2 (en) * 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
AU2007339793A1 (en) * 2006-12-29 2008-07-10 Applied Biosystems, Llc Systems and methods for detecting nucleic acids
EP2118310B1 (fr) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systemes et procedes pour la detection d'acide nucleique
US20080167198A1 (en) * 2007-01-04 2008-07-10 Christopher Gerard Cooney Filter based detection system
EP2115173B1 (fr) 2007-01-08 2011-09-21 Government of the USA, as Represented by the Secretary, Department of Health and Human Services Genotype slco1b3
US7820389B2 (en) * 2007-01-10 2010-10-26 Geneohm Sciences, Inc. Inhibition of mismatch hybridization by a universal competitor DNA
EP2121977B1 (fr) * 2007-01-11 2017-06-21 Erasmus University Medical Center Capture des chromosomes avec une conformation circulaire
US20100004134A1 (en) * 2007-01-12 2010-01-07 Lawrence Horowitz Combinatorial libraries of conformationally constrained polypeptide sequences
WO2008087641A2 (fr) * 2007-01-16 2008-07-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Agents nucléotidiques de silençage de h19 destinés au traitement de l'arthrite rhumatoïde
US8247195B2 (en) * 2007-01-16 2012-08-21 The University Of Washington Methods and host cells for recombinant protein expression
US20080171906A1 (en) * 2007-01-16 2008-07-17 Everaerts Frank J L Tissue performance via hydrolysis and cross-linking
CA2675366A1 (fr) * 2007-01-18 2008-07-24 University Of Southern California Polymorphismes geniques predictifs d'une bitherapie a base de tki
WO2008088860A2 (fr) 2007-01-18 2008-07-24 University Of Southern California Polymorphismes présents dans la voie de signalisation de l'egfr utilisés comme marqueurs pour le traitement du cancer
EP2109627A4 (fr) * 2007-01-22 2014-07-23 Wafergen Inc Appareil permettant la mise en oeuvre de réactions chimiques à haut rendement
JP5124593B2 (ja) * 2007-01-25 2013-01-23 デュポン ニュートリション バイオサイエンシーズ エーピーエス 形質転換バチルス・リケニフォルミス細胞からの脂質アシルトランスフェラーゼの製造
WO2008093331A1 (fr) * 2007-01-29 2008-08-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Conjugues d'anticorps pour vaincre la multiresistances aux medicaments
EA024233B1 (ru) 2007-01-29 2016-08-31 Сайнтифик Инститьют Оф Паблик Хелт (Ипх) Способы, реагенты, материалы и наборы для исследования образца на наличие или отсутствие материала, происходящего от одного или нескольких независимых трансформантов растений
NZ598285A (en) 2007-01-30 2013-10-25 Syngenta Participations Ag Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
US7695915B2 (en) 2007-01-31 2010-04-13 Celera Corporation Molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
US8293489B2 (en) * 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
WO2008093341A2 (fr) 2007-01-31 2008-08-07 Technion Research & Development Foundation Ltd. Échafaudages électrofilés et leurs procédés de génération et d'utilisation
US8546333B2 (en) 2007-02-01 2013-10-01 Technion Research & Development Foundation Limited Albumin fibers and fabrics and methods of generating and using same
EP2121983A2 (fr) 2007-02-02 2009-11-25 Illumina Cambridge Limited Procedes pour indexer des echantillons et sequencer de multiples matrices nucleotidiques
WO2008092213A1 (fr) 2007-02-02 2008-08-07 Genera Biosystems Pty Ltd Génération de molécules d'acide nucléique
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
EP1956097A1 (fr) * 2007-02-06 2008-08-13 bioMerieux B.V. Procédé de discrimination des polymorphismes mononucléotidiques (SNPs)
US8143046B2 (en) * 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US8168415B2 (en) 2007-02-07 2012-05-01 The Regents Of The University Of Colorado Axl fusion proteins as Axl tyrosine kinase inhibitors
US20080220498A1 (en) * 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
EP2118298B1 (fr) 2007-02-08 2013-01-09 Sequenom, Inc. Tests a base d'acide nucléique destinés au typage rhd
MY147186A (en) 2007-02-09 2012-11-14 Univ California Biofuel production by recombinant microorganisms
US20110020797A1 (en) * 2007-02-09 2011-01-27 Bristol-Myers Squibb Company Methods For Identifying Patients With An Increased Likelihood Of Responding To DPP-IV Inhibitors
EP2121969B1 (fr) * 2007-02-14 2012-04-04 Laboklin GmbH & Co. KG Procede de detection de la myopathie equine par retention de polysaccharide
US20090258360A1 (en) * 2007-02-14 2009-10-15 Valberg Stephanie J Method of detecting equine polysaccharide storage myopathy
US8012691B2 (en) 2007-02-20 2011-09-06 Applied Biosystems, Llc Multiplex compositions and methods for quantification of human nuclear DNA and human male DNA and detection of PCR inhibitors
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
BRPI0807952A2 (pt) * 2007-02-20 2014-06-10 Anaptysbio Inc Sistemas de hipermutação somática
SG178811A1 (en) * 2007-02-21 2012-03-29 Decode Genetics Ehf Genetic susceptibility variants associated with cardiovascular disease
EP1962084A1 (fr) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Appareil d'émission et de détection de faisceaux lumineux
EP2126132B1 (fr) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Procédé d'analyse d'adn médico-légale rapide
US9581595B2 (en) 2007-02-26 2017-02-28 Laboratory Corporation Of America Holdings Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
EP1961825A1 (fr) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Procédé pour prévoir l'apparition de métastase dans les patients souffrant d'un cancer du sein
EP2124952A2 (fr) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Méthode de traitement d'amyloïdoses
EP2134373A4 (fr) 2007-02-28 2014-04-02 Yeda Res & Dev Sequences de ciblage du noyau
EP2121920B1 (fr) * 2007-03-01 2011-08-24 Symphogen A/S Procede de clonage d'anticorps apparentes
JP5225294B2 (ja) * 2007-03-02 2013-07-03 コーベット リサーチ プロプライエタリー リミテッド 核酸増幅のための装置および方法
EP2243834A1 (fr) 2007-03-05 2010-10-27 Cancer Care Ontario Evaluation du risque de cancer colorectal
EP1970440A1 (fr) * 2007-03-06 2008-09-17 Qiagen GmbH Stabilisation de polymérase par des détergents ioniques
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
WO2008110513A1 (fr) 2007-03-09 2008-09-18 Novozymes A/S Asparaginases
EP2126089A2 (fr) 2007-03-09 2009-12-02 Danisco US, INC., Genencor Division Variants de l'a-amylase d'une espèce de bacillus alcaliphile, compositions comprenant des variants de l'a-amylase, et procédés d'utilisation
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
US8617816B2 (en) * 2007-03-16 2013-12-31 454 Life Sciences, A Roche Company System and method for detection of HIV drug resistant variants
US8871470B2 (en) 2007-03-21 2014-10-28 Applied Biosystems, Llc Adaptive thermal block temperature control method and system
EP2134365B1 (fr) 2007-03-21 2019-03-13 Effat Emamian Compositions et procédés d'inhibition de la croissance des cellules tumorales
US8153064B2 (en) 2007-03-22 2012-04-10 Doebler Ii Robert W Systems and devices for isothermal biochemical reactions and/or analysis
WO2008118324A2 (fr) 2007-03-26 2008-10-02 Macrogenics, Inc. Composition et procédé de traitement du cancer avec un anticorps anti-uroplakine ib
EP2140031A4 (fr) 2007-03-26 2011-04-20 Sequenom Inc Detection de sequence polymorphe amplifiee par endonuclease de restriction
JP5779350B2 (ja) 2007-03-27 2015-09-16 シー レーン バイオテクノロジーズ, エルエルシー 抗体代替軽鎖配列を含む構築物およびライブラリー
US7892739B2 (en) * 2007-03-27 2011-02-22 Lehigh University Systems, compositions and methods for nucleic acid detection
WO2008121291A1 (fr) * 2007-03-28 2008-10-09 Monsanto Technology Llc Utilité de marqueurs snp associés avec des régions majeures du port et de la maturité de plantes de soja
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
CA2682093A1 (fr) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Anticorps, procedes et kits de diagnostic et de traitement de melanomes
US20100130600A1 (en) * 2007-03-30 2010-05-27 Cedars-Sinai Medical Center Lipoprotein lipase and its effect on statin treatments
EP1978111B1 (fr) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits et procédés associés pour la détection et/ou la surveillance de Pseudomonas aeruginosa
US10017827B2 (en) 2007-04-04 2018-07-10 Nidera S.A. Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use
WO2008122084A1 (fr) * 2007-04-05 2008-10-16 Johnson & Johnson Research Pty Limited Enzymes et complexes d'acides nucléiques et leurs procédés d'utilisation
JPWO2008126827A1 (ja) * 2007-04-06 2010-07-22 ユニバーサル・バイオ・リサーチ株式会社 温度制御装置および温度制御方法
EP2191001B1 (fr) 2007-04-09 2016-06-08 University of Florida Research Foundation, Inc. Compositions à base de vecteurs raav comprenant des protéines de capside modifiées par la tyrosine et procédés d'utilisation correspondants
AU2008236316B2 (en) * 2007-04-09 2013-05-02 Evogene Ltd. Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US7910342B2 (en) 2007-04-18 2011-03-22 Butamax(Tm) Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
AU2008242250B2 (en) 2007-04-19 2014-03-27 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20110213006A1 (en) * 2007-04-20 2011-09-01 Immunotrex Corporation Compositions and Methods for Treatment of Uncontrolled Cell Growth
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
EP2144633B1 (fr) * 2007-04-23 2014-07-16 Deliversir Ltd Système pour administrer des agents thérapeutiques dans des cellules vivantes et noyaux de cellules
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US8629245B2 (en) 2007-05-01 2014-01-14 Research Development Foundation Immunoglobulin Fc libraries
EP3032259B1 (fr) 2007-05-01 2020-04-15 Tel Hashomer Medical Research Infrastructure and Services Ltd. Procédés de détection des cellules trophoblastiques dans le sang maternel sur la base de la cytokératine-7
ES2583003T3 (es) 2007-05-01 2016-09-16 University Of Miami Un biomarcador transcriptómico de miocarditis
JP5714326B2 (ja) * 2007-05-01 2015-05-07 ユニバーシティ オブ マイアミ 新規に進行中の心不全における個人のリスク評価のためのトランスクリプトームのバイオマーカー
CA2587198A1 (fr) * 2007-05-02 2008-11-02 Spartan Bioscience Inc. Procede permettant d'accelerer les reactions d'amplification d'acides nucleiques
US20090124508A1 (en) * 2007-05-02 2009-05-14 Anthony Peter Caruso Computational diagnostic methods for identifying organisms and applications thereof
GB2462048B (en) 2007-05-03 2012-03-21 Agency Science Tech & Res Antibodies binding to an intracellular prl-1 or prl-3 polypeptide
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
JP2010525837A (ja) * 2007-05-04 2010-07-29 マイコノスティカ リミテッド アスペルギルス(Aspergillus)におけるトリアゾール耐性の検出
SG187447A1 (en) 2007-05-07 2013-02-28 Protalix Ltd Large scale disposable bioreactor
US20090074740A1 (en) * 2007-05-14 2009-03-19 Noah Berkowitz Use of haptoglobin genotyping in diagnosis and treatment of defective reverse cholesterol transport (RCT)
WO2008141514A1 (fr) * 2007-05-17 2008-11-27 Wondergen Bio-Medicine Technology Co., Ltd. Pcr de substitution de système
US8093016B2 (en) * 2007-05-21 2012-01-10 Danisco Us Inc. Use of an aspartic protease (NS24) signal sequence for heterologous protein expression
AU2008260089A1 (en) * 2007-05-29 2008-12-11 Yale University Methods and compositions related to riboswitches that control alternative splicing and RNA processing
EP2426218A1 (fr) * 2007-05-29 2012-03-07 Yale University Riborégulateurs (riboswitches) et procédés et compositions à utiliser avec les riborégulateurs
EP2183386A1 (fr) 2007-05-31 2010-05-12 Yale University Une lésion génétique associée à un cancer
CA2689695A1 (fr) 2007-05-31 2008-12-04 Genmab A/S Animaux transgeniques produisant des anticorps humains monovalents et anticorps pouvant s'obtenir a partir de ces animaux
AU2008255641B2 (en) 2007-05-31 2014-03-13 Board Of Regents Of The University Of Texas System Diagnostic markers for ankylosing spondylitis and uses thereof
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
EP2152849B1 (fr) 2007-06-01 2013-02-20 Solazyme, Inc. Production d'huile dans des micro-organismes
AU2008259342B2 (en) 2007-06-04 2014-07-10 Ben-Gurion University Of The Negev Research And Development Authority Tri-aryl compounds and compositions comprising the same
WO2008153934A2 (fr) * 2007-06-06 2008-12-18 Danisco Us, Inc., Genencor Division Procédés d'amélioration de la performance des protéines
FR2917090B1 (fr) * 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
JP5356373B2 (ja) 2007-06-15 2013-12-04 ナショナル リサーチ カウンシル オブ カナダ 酵素特性を向上させたポリシアリルトランスフェラーゼの操作されたバージョン
ES2523587T3 (es) 2007-06-18 2014-11-27 Medimmune, Llc Virus influenza B que tienen alteraciones en el polipéptido hemaglutinina
ES2477232T5 (es) * 2007-06-21 2017-11-23 Momenta Pharmaceuticals, Inc. Análisis de copolímeros
US20090324596A1 (en) * 2008-06-30 2009-12-31 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
US10745701B2 (en) 2007-06-28 2020-08-18 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
EP2395113A1 (fr) 2007-06-29 2011-12-14 Population Genetics Technologies Ltd. Procédés et compositions d'isolation des variantes de séquence d'acide nucléique
ES2725450T3 (es) 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
GB0713183D0 (en) * 2007-07-06 2007-08-15 King S College London Method
EP3018216B1 (fr) 2007-07-06 2018-09-12 The Regents Of The University Of Michigan Fusions de gène récurrentes dans le cancer de la prostate
ATE533861T1 (de) 2007-07-06 2011-12-15 Univ Michigan Mipol1-etv1-gen-neuanordnungen
US8383589B2 (en) * 2007-07-09 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aegyptin and uses thereof
WO2009009759A2 (fr) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Antigènes yersinia pestis, compositions de vaccins, et méthodes associées
EP2176409B1 (fr) 2007-07-11 2012-01-04 Yeda Research And Development Co. Ltd. Systèmes de produits de construction d'acide nucléique pouvant diagnostiquer ou traiter un état cellulaire
CA2693677C (fr) 2007-07-12 2018-02-13 Tolerx, Inc. Therapies combinees utilisant des molecules de liaison au gitr
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
JP2010533705A (ja) 2007-07-15 2010-10-28 ヒルマン,イチャク 抗菌ペプチドまたはその阻害剤を用いた疾病治療
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
EP2182943B1 (fr) 2007-07-23 2016-10-26 Janssen Biotech, Inc. Procédés et compositions pour traiter des troubles associés à une fibrose en utilisant des antagonistes de l'il-17
AU2008278654B2 (en) * 2007-07-24 2014-06-05 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
AU2008279868B2 (en) 2007-07-26 2014-03-20 Monsanto Holland B.V. Novel polygalacturonases and their uses
US8221981B2 (en) * 2007-07-30 2012-07-17 Argos Therapeutics, Inc. Primers and probes for the amplification and detection of HIV Gag, Rev and Nef polynucleotides
CN104673784A (zh) * 2007-07-31 2015-06-03 Bp法人北美有限公司 修剪式多位点组合装配
WO2009018473A1 (fr) * 2007-07-31 2009-02-05 Micronics, Inc. Système de récupération d'écouvillon sanitaire, dispositif d'analyse microfluidique et procédés pour des analyses de diagnostic
US8008011B2 (en) * 2007-07-31 2011-08-30 University Of Saskatchewan Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
KR101376359B1 (ko) * 2007-08-01 2014-03-27 다나-파버 캔서 인스티튜트 인크. 표적 서열 강화
CA2693208A1 (fr) 2007-08-02 2009-02-05 Victoria Smith Procedes et compositions de traitement et de diagnostic de fibrose, d'invasion tumorale, d'angiogenese et de metastase
US8143006B2 (en) * 2007-08-03 2012-03-27 Igor Kutyavin Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking
CN101361968B (zh) 2007-08-06 2011-08-03 健能隆医药技术(上海)有限公司 白介素-22在治疗脂肪肝中的应用
EP2952588A1 (fr) 2007-08-06 2015-12-09 Orion Genomics, LLC Polymorphismes de nucléotide unique pour déterminer l'expression spécifique d'allèle du gène igf2
WO2009032486A1 (fr) * 2007-08-13 2009-03-12 3M Innovative Properties Company Méthodes de détection des microbes résistant aux médicaments
DK2185175T3 (da) 2007-08-15 2013-05-13 Yeda Res & Dev MMP-9-regulatorer og anvendelser deraf
US8071561B2 (en) * 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
WO2009022338A2 (fr) 2007-08-16 2009-02-19 Saher Hamed Compositions d'érythropoïétine et de fibronectine pour applications thérapeutiques et cosmétiques
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US7897139B2 (en) 2007-08-17 2011-03-01 Biochrom Pharma, Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
US8501929B2 (en) 2007-08-17 2013-08-06 Biochrom Pharma Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
EP2487169B1 (fr) 2007-08-21 2015-05-20 Senomyx, Inc. Composés qui inhibent (bloquent) le goût amer dans des compositions et leur utilisation
US20090055243A1 (en) 2007-08-21 2009-02-26 Jayson Lee Lusk Systems and methods for predicting a livestock marketing method
US20090142763A1 (en) * 2007-08-22 2009-06-04 Wyeth Nested pcr-based method for specific genotyping of the fc gamma receptor iiia gene
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US20090263869A1 (en) 2007-08-27 2009-10-22 Lei Xi Methods and Compositions for PCR
EP2772267B1 (fr) 2007-08-27 2016-04-27 Longhorn Vaccines and Diagnostics, LLC Compositions immunogènes et procédés
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US9234244B2 (en) * 2007-08-27 2016-01-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic tool for diagnosing benign versus malignant thyroid lesions
EP2190566B1 (fr) * 2007-08-28 2012-10-03 Corbett Research Pty Ltd Dispositif de cyclage thermique comportant un accès d'échantillon pouvant être ouvert sélectivement
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
CA3024820C (fr) 2007-08-29 2022-06-21 Monsanto Technology Llc Procede et compositions utiles pour l'amelioration genetique assurant des caracteres preferes associes a la resistance a la fletrissure de goss dans les plantes
JP2009055815A (ja) * 2007-08-30 2009-03-19 Olympus Corp プライマーキット
CN101868476B (zh) 2007-09-05 2015-02-25 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途
CA2699150A1 (fr) * 2007-09-10 2009-03-19 Mascoma Corporation Plasmides issus d'organismes thermophiles, vecteurs en derivant et leurs utilisations
US8741315B2 (en) 2007-09-12 2014-06-03 Yeda Research And Development Co. Ltd. Methods of treating tumors in immune-privileged sites
FR2921064A1 (fr) * 2007-09-14 2009-03-20 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence du gene e1 du virus du chikungunya
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
CA2699376C (fr) 2007-09-14 2018-10-23 University Of South Florida Signature genetique predictive d'une reponse a la radiotherapie
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
WO2009039136A2 (fr) * 2007-09-17 2009-03-26 Siometrix Corporation Dispositifs de détection produisant un signal à auto-activation et procédés
BRPI0815946B8 (pt) 2007-09-19 2021-05-25 Pluristem Ltd artigo de fabricação
US8889361B2 (en) * 2007-09-19 2014-11-18 The Research Foundation For The State University Of New York Gene expression signatures in enriched tumor cell samples
WO2009039466A1 (fr) 2007-09-20 2009-03-26 Vanderbilt University Mesure de solution libre d'interactions moléculaires par interférométrie rétrodiffusée
US7695963B2 (en) * 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
HUE052423T2 (hu) 2007-09-28 2021-04-28 Alexion Pharma Inc Az XA faktor inhibitorok antidótumai és ezek alkalmazási módszerei
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
CA2701168A1 (fr) 2007-10-01 2009-07-09 Longhorn Vaccines & Diagnostics, Llc Systeme de prelevement et de transport d'echantillons biologiques et procedes d'utilisation
US8486680B2 (en) 2007-10-03 2013-07-16 Bp Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
KR101110013B1 (ko) * 2007-10-05 2012-02-29 (주)바이오니아 서열 내에 어베이직 부분을 포함하는 pcr 증폭용프라이머
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
EP2265375A1 (fr) 2007-10-12 2010-12-29 Rheonix, Inc. Dispositif microfluidique intégré et procédés
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
US8450106B2 (en) * 2007-10-17 2013-05-28 The Ohio State University Research Foundation Oncolytic virus
WO2009052386A1 (fr) * 2007-10-18 2009-04-23 Asuragen, Inc. Micro arn exprimés différentiellement dans des maladies pulmonaires et leurs utilisations
AU2008313274A1 (en) 2007-10-19 2009-04-23 Rappaport Family Institute For Research In The Medical Sciences Compositions comprising semaphorins for the treatment of angiogenesis related diseases and methods of selection thereof
WO2009055350A1 (fr) * 2007-10-23 2009-04-30 Allergan, Inc. Procédés de traitement d'une inflammation neurogénique chronique à l'aide de toxines clostridiennes modifiées
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer
US20090170925A1 (en) 2007-10-29 2009-07-02 Eisai R&D Management Co., Ltd. Methods for prognosing the ability of a zearalenone analog compound to treat cancer
CA2739011A1 (fr) * 2007-10-29 2009-05-07 The Regents Of The University Of California Therapie genique pour l'osteoarthrite
DK2215209T3 (en) 2007-10-30 2018-09-03 Complete Genomics Inc DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS
TW200930818A (en) 2007-10-30 2009-07-16 Applied Biosystems Method and kits for multiplex amplification of short tandem repeat loci
WO2009059170A2 (fr) 2007-10-31 2009-05-07 Idexx Laboratories, Inc. Diva de l'ehrlichia canis (différentiation de l'infection des animaux vaccinés)
DK2222697T3 (da) 2007-11-01 2013-03-11 Perseid Therapeutics Llc Immunsuppressive polypeptider og nukleinsyrer
WO2009058303A2 (fr) 2007-11-01 2009-05-07 Danisco Us Inc., Genencor Division Production de thermolysine et de ses variants et utilisation dans des détergents liquides
CA2704787A1 (fr) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Genes et polymorphismes associes a l'amd
US8679749B2 (en) * 2007-11-01 2014-03-25 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
KR20100088670A (ko) * 2007-11-05 2010-08-10 다니스코 유에스 인크. 증가된 열안정성 및/또는 감소된 칼슘 의존성을 갖는 바실러스 리체니포르미스 알파-아밀라아제의 변이체
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US7541026B2 (en) * 2007-11-05 2009-06-02 Danisco Us Inc., Genencor Division Alpha-amylase variants with altered properties
NZ584434A (en) * 2007-11-05 2011-12-22 Danisco Us Inc VARIANTS OF BACILLUS sp. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES
US9273100B2 (en) 2007-11-09 2016-03-01 Board Of Trustees Of Michigan State University Use of Galerina marginata genes and proteins for peptide production
US9518097B2 (en) * 2007-11-09 2016-12-13 Board Of Trustees Of Michigan State University Identification and use of genes encoding amatoxin and phallotoxin
MX2010005244A (es) 2007-11-12 2010-10-25 Theraclone Sciences Inc Composiciones y métodos para la terapia y el diagnóstico de influenza.
US20110033476A1 (en) * 2007-11-12 2011-02-10 Theraclone Sciences Inc. Compositions and methods for the therapy and diagnosis of influenza
WO2009064944A2 (fr) 2007-11-16 2009-05-22 Nuvelo, Inc. Anticorps dirigés contre lrp6
US7892760B2 (en) 2007-11-19 2011-02-22 Celera Corporation Lung cancer markers, and uses thereof
US8431158B2 (en) 2007-11-26 2013-04-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions comprising fibrous polypeptides and polysaccharides
WO2015164330A1 (fr) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Molécules d'anticorps anti-psyk et leur utilisation pour la thérapie ciblée sur syk
US8470964B2 (en) * 2007-11-28 2013-06-25 Enkam Pharmaceuticals A/S Peptides derived from NCAM (FGLs)
SG10201402188TA (en) * 2007-11-30 2014-06-27 Corbett Res Pty Ltd Thermal cycling device
WO2009082593A2 (fr) * 2007-11-30 2009-07-02 Baylor College Of Medicine Compositions de vaccin à cellules dendritiques et utilisations de celles-ci
WO2009070805A2 (fr) 2007-12-01 2009-06-04 Asuragen, Inc. Gènes régulés par le mir-124 et cheminements servant de cibles pour une intervention thérapeutique
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
EP2067787A1 (fr) 2007-12-06 2009-06-10 Boehringer Ingelheim International GmbH Procédé pour le contrôle de populations d'insectes
EP2071034A1 (fr) 2007-12-12 2009-06-17 bioMérieux Procédé pour le traitement d'une solution en vue d'éliminer un acide ribonucléique après amplification
BRPI0823506A8 (pt) 2007-12-13 2018-05-15 Danisco Us Inc Genencor Div composições e métodos para a produção de isoprene
KR101499278B1 (ko) 2007-12-17 2015-03-06 화이자 리미티드 간질성 방광염의 치료
CN105732813A (zh) 2007-12-18 2016-07-06 生物联合公司 识别癌细胞上表达的cd-43和cea的含糖表位的抗体及其使用方法
KR101665143B1 (ko) 2007-12-19 2016-10-11 캔써 리서치 테크놀로지 리미티드 피리도[2,3-b]피라진-8 치환 화합물 및 이의 용도
BRPI0819541A2 (pt) 2007-12-20 2017-05-23 Butamax Advanced Biofuels Llc "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol"
EP2235151B1 (fr) * 2007-12-21 2012-09-12 DuPont Nutrition Biosciences ApS Procédé de raffinage d'huiles comestibles utilisant une acyltransférase de lipides
CN101903519B (zh) 2007-12-21 2013-07-31 丹尼斯科美国公司 杆菌中增强的蛋白质生产
EP3434785A1 (fr) 2007-12-21 2019-01-30 bioMerieux SA Détection de staphylococcus aureus résistant à la méthicilline
EP2227537A4 (fr) * 2007-12-24 2014-05-07 Honeywell Int Inc Réacteur pour l'analyse quantitative d'acides nucléiques
US9005931B2 (en) * 2007-12-24 2015-04-14 Honeywell International Inc. Programmable oligonucleotide micro array
AU2008343380B2 (en) * 2007-12-26 2012-07-12 Gen-Probe Incorporated Compositions and methods to detect Candida albicans nucleic acid
WO2009085333A1 (fr) 2007-12-27 2009-07-09 Ge Healthcare Bio-Sciences Corp. Système à enzyme unique pour une pcr rapide, ultra-longue
JP5697988B2 (ja) 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉rnaを使用したポロ様キナーゼ発現のサイレンシング方法
AU2008344935C1 (en) 2007-12-27 2016-07-14 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants
DE102007063102B4 (de) * 2007-12-28 2022-02-10 Robert Bosch Gmbh Verfahren zur Erfassung eines periodisch pulsierenden Betriebsparameters
US8367899B2 (en) 2007-12-31 2013-02-05 E I Du Pont De Neumours And Company Gray leaf spot tolerant maize and methods of production
EP2570498A3 (fr) 2008-01-02 2013-03-27 Suregene Llc Marqueurs génétiques de maladie mentale
CA2710922A1 (fr) 2008-01-03 2009-07-16 Verenium Corporation Isomerases, acides nucleiques codant pour celles-ci et leurs procedes de fabrication d'utilisation
US8709772B2 (en) 2008-01-03 2014-04-29 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
EP2232259B1 (fr) 2008-01-09 2016-10-12 Keck Graduate Institute Système, appareil et procédé pour la préparation et/ou la manipulation de matériau
BRPI0906429B1 (pt) 2008-01-10 2021-08-03 Research Development Foundation Método de identificação de uma infecção por e. chaffeensis em um indivíduo, uso de um ou mais polipeptídeo sintético e kit
EP2581454B1 (fr) 2008-01-17 2015-09-16 Suregene LLC Marqueurs génétiques de maladie mentale
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
PT2240781T (pt) 2008-01-18 2018-03-28 Harvard College Métodos de deteção de assinaturas de doença ou afeções em fluidos corporais
GB0800938D0 (en) * 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
FR2926560A1 (fr) * 2008-01-21 2009-07-24 Millipore Corp Procede d'extraction et de purification d'acides nucleiques sur membrane
US9170060B2 (en) * 2008-01-22 2015-10-27 Lawrence Livermore National Security, Llc Rapid microfluidic thermal cycler for nucleic acid amplification
AU2009208035B2 (en) 2008-01-22 2014-04-03 Dogenes Inc. Compositions and methods for detecting Juvenile Renal Dysplasia or calcium oxalate stones in dogs
US20090186344A1 (en) * 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
MX356866B (es) 2008-01-25 2018-06-18 Multivir Inc Biomarcadores p53.
CN105106186A (zh) * 2008-01-31 2015-12-02 范德比尔特大学 治疗冠状动脉和动脉的动脉瘤性蛛网膜下腔出血的方法和组合物
PL2247297T3 (pl) * 2008-01-31 2019-07-31 Vanderbilt University Działanie terapeutyczne w stanach chorobowych płuc
EP2245055A2 (fr) * 2008-01-31 2010-11-03 Compugen Ltd. Polypeptides et polynucléotides et leurs utilisations en tant que cible médicamenteuse pour produire des médicaments et des produits biologiques
CN101970634B (zh) 2008-02-04 2014-01-22 丹尼斯科美国公司 具有改变性质的TS23α-淀粉酶变体
US20110086048A1 (en) * 2008-02-06 2011-04-14 University Of Massachusetts Detection of human immunodeficiency virus co-receptor tropism in aviremic subjects
US20090203022A1 (en) * 2008-02-07 2009-08-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Analysis
EP2252702B1 (fr) * 2008-02-08 2014-01-29 Mayo Foundation for Medical Education and Research Detection de clostridium difficile
JP2011511635A (ja) * 2008-02-11 2011-04-14 ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド 癌標識としての結腸癌関連転写因子1(ccat−1)
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
JP5767813B2 (ja) 2008-02-15 2015-08-19 モンサント テクノロジー エルエルシー トランスジェニック事象mon87769に対応するダイズ植物および種子ならびにそれらを検出する方法
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CA2716337C (fr) * 2008-02-20 2017-11-14 Streck, Inc. Thermocycleur et recipient a echantillons pour l'amplification rapide de l'adn
US20110091866A1 (en) * 2008-02-20 2011-04-21 Kosuke Ken Iwaki Detection of polyomavirus
DK2857525T3 (da) 2008-02-29 2019-07-22 Univ Oxford Innovation Ltd Fremgangsmåde til bestemmelse af en passende dosis statin
AR070495A1 (es) 2008-02-29 2010-04-07 Monsanto Technology Llc Evento de maiz mon87460 y composiciones y metodos para detectarlo
US8153374B2 (en) * 2008-03-03 2012-04-10 Heatflow Technologies, Inc. Heat flow polymerase chain reaction methods
US8030471B2 (en) 2008-03-06 2011-10-04 Abbott Laboratories Plasmodium malariae and Plasmodium ovale genes and uses thereof
US8268981B2 (en) * 2008-03-06 2012-09-18 Abbott Laboratories Plasmodium malariae and plasmodium ovale genes and uses thereof
JP5544309B2 (ja) 2008-03-10 2014-07-09 セラクローン サイエンシーズ, インコーポレイテッド サイトメガロウイルス感染の治療および診断のための組成物および方法
US9074244B2 (en) * 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
CA2710807C (fr) 2008-03-11 2015-09-08 Kyeong Man Hong Procede d'evaluation de nombre de copies de chromosome, gene ou sequence nucleotidique specifique reposant sur l'utilisation d'un jeu snp
CA2717320A1 (fr) 2008-03-11 2009-09-17 Sequenom, Inc. Tests adn pour determiner le sexe d'un bebe avant sa naissance
EP2257634A1 (fr) * 2008-03-12 2010-12-08 Wyeth LLC Procédé pour identifier des cellules appropriées pour une production à grande échelle de protéines recombinantes
GB0804662D0 (en) * 2008-03-13 2008-04-16 Guy S & St Thomas S Nhs Founda Drug response marker
MX2010010161A (es) * 2008-03-15 2011-03-21 Hologic Inc Star Composiciones y metodos para el analisis de moleculas de acido nucleico durante reacciones de amplificacion.
CN102027136A (zh) 2008-03-17 2011-04-20 表现研究有限公司 发现表达连接基因
US8153370B2 (en) * 2008-03-19 2012-04-10 The Board Of Trustees Of The University Of Illinois RNA from cytology samples to diagnose disease
US8536135B2 (en) * 2008-03-19 2013-09-17 Ontherix, Inc. Adaptive biochemical signatures
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
JP2011518126A (ja) * 2008-03-25 2011-06-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン IKKi阻害剤の処置方法およびスクリーニング方法、ならびに関連するIKKi診断方法
EP2276858A4 (fr) 2008-03-26 2011-10-05 Sequenom Inc Détection de séquence polymorphique amplifiée par endonucléase de restriction
US7998722B2 (en) * 2008-03-27 2011-08-16 E. I. Du Pont De Nemours And Company Zymomonas with improved xylose utilization
SI2757091T1 (en) 2008-04-01 2018-01-31 Biosearch Technologies, Inc. Stabilized nucleic acid black gas-fluorofor probe
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
US20090280103A1 (en) * 2008-04-04 2009-11-12 Martin Flueck Regulation of muscle repair
ATE537272T1 (de) 2008-04-08 2011-12-15 Hoffmann La Roche Detektion von pcr-produkten in der gelelektrophorese
WO2009126726A1 (fr) * 2008-04-08 2009-10-15 Asuragen, Inc Procédés et compositions pour diagnostiquer et moduler le papillomavirus humain (hpv)
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
WO2009126789A2 (fr) 2008-04-09 2009-10-15 Maxcyte, Inc. Préparation et administration de compositions thérapeutiques de cellules fraîchement isolées
EP2132337B1 (fr) * 2008-04-09 2011-11-02 Laboklin GmbH & Co. KG Procede de detection d'un collapsus canin induit par l'exercice
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP2108451A1 (fr) 2008-04-11 2009-10-14 Eppendorf AG Dispositif d'exécution de réactions dans des échantillons
PT2279254T (pt) 2008-04-15 2017-09-04 Protiva Biotherapeutics Inc Novas formulações lipídicas para entrega de ácido nucleico
JP2011516094A (ja) 2008-04-15 2011-05-26 プロチバ バイオセラピューティクス インコーポレイティッド 干渉rnaを用いたcsn5遺伝子発現のサイレンシング方法
GB0807161D0 (en) * 2008-04-18 2008-05-21 Danisco Process
EP2283124B1 (fr) 2008-04-18 2016-05-25 Danisco US Inc. Variants de phytase de buttiauxella sp
US9249455B2 (en) * 2008-04-18 2016-02-02 Luminex Corporation Methods for detection and quantification of small RNA
CA2721507C (fr) 2008-04-18 2017-10-03 Collplant Ltd. Procedes de generation et d'utilisation de procollagene
EP2444491B1 (fr) 2008-04-21 2016-11-16 Novo Nordisk Healthcare Ag Facteur IX de coagulation humain hyperglycosylé
US10150990B2 (en) 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
EP2268129B1 (fr) 2008-04-21 2015-06-17 Danziger Innovations Ltd. Vecteurs d'expression de virus végétaux et leur utilisation pour générer des variations génotypiques dans des génomes de plantes
ZA201007564B (en) * 2008-04-23 2012-01-25 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
CN104388568B (zh) 2008-04-24 2017-04-12 孟山都技术有限公司 鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
CN102016026B (zh) 2008-04-25 2014-07-02 东丽株式会社 含有来自丙型肝炎病毒的嵌合基因的核酸
WO2009134785A1 (fr) * 2008-04-28 2009-11-05 Michigan Technological University Éléments promoteurs spécifiques de fibres
EP2113574A1 (fr) 2008-04-28 2009-11-04 Biotype AG Substances et procédés pour un dosage de profilage à base d'ADN
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
DK2281034T3 (en) 2008-04-30 2016-01-25 Dupont Nutrition Biosci Aps A method using alcohol dehydrogenase Pseudoglucanobacter saccharoketogenes
US10227641B2 (en) 2008-04-30 2019-03-12 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
JP5539325B2 (ja) 2008-04-30 2014-07-02 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド 修飾されたrna単量体を用いるrnアーゼhを基礎とするアッセイ
US20110118125A1 (en) * 2008-05-03 2011-05-19 Tufts Medical Center, Inc. Neonatal salivary genomics
CA2723536C (fr) 2008-05-05 2017-06-13 Los Alamos National Security, Llc Preparation d'echantillon d'acide nucleique base sur un ecoulement lateral hautement simplifie et regulation d'ecoulement de fluide passive
EP2990487A1 (fr) 2008-05-08 2016-03-02 Asuragen, INC. Compositions et procédés relatifs à la modulation de miarn de néovascularisation ou angiogenèse
EP2116618A1 (fr) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnostic et traitement de la maladie de Kawasaki
US9365842B2 (en) * 2008-05-11 2016-06-14 Stellenbosch University Nucleic acids encoding fungal cellobiohydrolases for expression in yeast
EP2288726B1 (fr) 2008-05-13 2012-06-13 Gen-Probe Incorporated Oligomères de capture de cible inactivables pour hybridation et capture sélectives de séquences d'acides nucléiques cibles
FI20085450A0 (fi) 2008-05-14 2008-05-14 Arto Orpana Menetelmä DNA-juosteen syntetisoimiseksi
AU2009246180B2 (en) 2008-05-14 2015-11-05 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
WO2010096036A2 (fr) 2008-05-14 2010-08-26 Millennium Pharmaceuticals, Inc. Méthodes et trousses pour surveiller les effets d'immunomodulateurs sur l'immunité adaptative
EP2993239A1 (fr) 2008-05-16 2016-03-09 AstraZeneca AB Procédés d'identification de sujets présentant un risque accru de réponse à des inhibiteurs de dpp-iv
US8895240B2 (en) * 2008-05-19 2014-11-25 E I Du Pont De Nemours And Company Method, kit and system for collecting and processing samples for DNA and RNA detection
EP2127751B1 (fr) 2008-05-19 2012-05-16 Roche Diagnostics GmbH Dispositif chauffant - refroidissant amélioré avec solide filme lubricante à sec
MX2010012697A (es) * 2008-05-22 2011-03-15 Evogene Ltd Polinucleotidos y polipeptidos aislados y metodos para usarlos para incrementar el rendimiento de plantas, biomasa, velocidad de crecimiento, vigor, contenido de aceite, tolerancia al estres abiotico de las plantas y eficiencia de uso de nitrogeno.
US9817001B2 (en) 2008-05-27 2017-11-14 Boston Heart Diagnostics Corporation Methods for determining LDL cholesterol treatment
EP2163239A1 (fr) * 2008-05-27 2010-03-17 Qiagen GmbH Produits comprenant des bioparticules, leur procédé de fabrication
GB2473778B (en) 2008-05-27 2013-04-10 Trilink Biotechnologies Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid
DE102008025328B4 (de) 2008-05-27 2013-10-17 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Zusammensetzungen und Verfahren zur Amplifikation von HI-Viren mittels Multiplex-PCR in multiplen Genombereichen
WO2009144720A1 (fr) 2008-05-27 2009-12-03 Pluristem Ltd. Procédés de traitement de maladies inflammatoires du côlon
CA2725978A1 (fr) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systemes et procedes de discrimination basee sur l'expression d'etats pathologiques cliniques distincts dans le cancer de la prostate
US8722348B2 (en) 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
EP3514229A1 (fr) 2008-05-28 2019-07-24 Ramot at Tel-Aviv University Ltd. Cellules souches mésenchymateuses destinées au traitement de troubles du snc
WO2009158119A2 (fr) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits et procédés associés pour la détection et/ou la surveillance de salmonelles
US9631239B2 (en) 2008-05-30 2017-04-25 University Of Utah Research Foundation Method of classifying a breast cancer instrinsic subtype
EP2296669B1 (fr) 2008-05-30 2012-03-21 Yale University Compositions oligonucléotidiques ciblées pour modifier l'expression génique
US8208909B2 (en) 2008-06-02 2012-06-26 West Corporation System, apparatus and method for availing a mobile call of address information
ES2587395T3 (es) 2008-06-04 2016-10-24 Cellular Dynamics International, Inc. Procedimientos para la producción de células IPS usando un enfoque no vírico
EP2130929B1 (fr) 2008-06-06 2013-10-09 F. Hoffmann-La Roche AG Détection multiplexe contrôlée en interne et quantification d'acides nucléiques microbiens
US8431692B2 (en) 2008-06-06 2013-04-30 Quark Pharmaceuticals, Inc. Compositions and methods for treatment of ear disorders
EP2623591B1 (fr) 2008-06-06 2016-08-24 Danisco US Inc. Variants d'alpha-amylase (AMYS) de Geobacillus stearothermophilus présentant des propriétés améliorées
MX360255B (es) 2008-06-06 2018-10-26 Danisco Us Inc Composiciones y metodos que comprenden proteasas microbianas variantes.
SI2304054T1 (sl) 2008-06-11 2017-11-30 Orion Pharma (Uk) Limited Izotermna ojačitev nukleinske kisline
ES2532883T3 (es) 2008-06-12 2015-04-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) TET2 como nuevo marcador de diagnóstico y de pronóstico en neoplasias hematopoyéticas
US9297046B2 (en) 2008-06-12 2016-03-29 Assistance Publique—Hopitaux de Paris TET2 as a new diagnostic and pronostic marker in hematopoietic neoplasms
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
WO2009150623A1 (fr) 2008-06-13 2009-12-17 Pfizer Inc Traitement de la prostatite chronique
US20090311677A1 (en) * 2008-06-13 2009-12-17 Andrew Reeves Identification of contaminating bacteria in industrial ethanol fermentations
US20110053226A1 (en) * 2008-06-13 2011-03-03 Riboxx Gmbh Method for enzymatic synthesis of chemically modified rna
US20110136118A1 (en) * 2008-06-17 2011-06-09 Sigma-Aldrich Co. Real time polymerase chain reaction process using a universal detection system
WO2010033285A2 (fr) 2008-06-26 2010-03-25 Spectrum Health Procédé utile pour traiter et prévenir les dommages dus au rayonnement et faisant appel à des cellules souches mésenchymateuses génétiquement modifiées
WO2009158563A1 (fr) * 2008-06-26 2009-12-30 Spectrum Health Méthode de traitement ou de prévention de lésions causées par irradiation par thérapie génique in vivo
EP2297357B1 (fr) 2008-06-27 2012-10-31 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Prédiction de la réponse à une thérapie antivirale
US8268796B2 (en) 2008-06-27 2012-09-18 Children's Hospital & Research Center At Oakland Lipophilic nucleic acid delivery vehicle and methods of use thereof
EP2313105B1 (fr) 2008-06-27 2013-07-24 ZymoGenetics, Inc. RÉCEPTEURS Fc gamma HYBRIDES SOLUBLES ET PROCÉDÉS ASSOCIÉS
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
EP2313428A2 (fr) * 2008-07-01 2011-04-27 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Les virus parainfluenza de type 1 recombinants humains (hpiv1s) contenant des mutations ou des délétions de la protéine c sont atténués chez les singes verts d afrique et dans les cellules épithéliales ciliées des voies respiratoires humaines et constituent des candidats vaccins potentiels contre hpiv1
JP2011526790A (ja) 2008-07-02 2011-10-20 ダニスコ・ユーエス・インク 分離された条件下および/または安全操業条件下における、c5炭化水素を含まないイソプレン組成物及びその製造方法
US20100120034A1 (en) * 2008-07-03 2010-05-13 Life Technologies Corporation Methylation analysis of mate pairs
WO2010006215A1 (fr) 2008-07-09 2010-01-14 Celera Corporation Polymorphismes génétiques associés à des maladies cardiovasculaires et procédés de détection et d'utilisation de ceux-ci
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
WO2010009365A1 (fr) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Bibliothèque de gouttelettes
US20100068711A1 (en) 2008-07-18 2010-03-18 Xenomics, Inc. Methods of PCR-Based Detection of "Ultra Short" Nucleic Acid Sequences
US8900851B2 (en) * 2008-07-22 2014-12-02 The Research Foundation For The State University Of New York Multi-well platform
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
KR101708946B1 (ko) * 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. 탈아세틸화제 억제제 및 그것의 용도
FR2934595B1 (fr) * 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2638458A1 (fr) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Recyclage thermique au moyen du positionnement d'une source de temperature allant de relative a fixe
CA2733200A1 (fr) * 2008-08-06 2010-02-11 Novo Nordisk Health Care Ag Proteines conjuguees a efficacite in vivo prolongee
WO2010017543A1 (fr) * 2008-08-08 2010-02-11 Smiths Detection Inc. Algorithme de détection pour analyse de pcr
EP2320953B1 (fr) 2008-08-08 2015-07-15 Genisphere, LLC Dendrimères d'adn à longue durée d'action et méthodes afférentes
KR20100019220A (ko) * 2008-08-08 2010-02-18 삼성전자주식회사 열순환을 포함하는 다중 치환 증폭에 의하여 표적 핵산 서열을 증폭하는 방법
US8685937B2 (en) 2008-08-09 2014-04-01 University Of Iowa Research Foundation Nucleic acid aptamers
EP2324126B1 (fr) 2008-08-12 2014-04-23 Zinfandel Pharmaceuticals, Inc. PROCÉDÉ D'IDENTIFICATION DE FACTEURS DE RISQUE DE la MALADIE d'Alzheimer
CN102171348A (zh) 2008-08-12 2011-08-31 细胞动力国际有限公司 产生ips细胞的方法
EP2326668B1 (fr) 2008-08-14 2018-01-17 Teva Pharmaceuticals Australia Pty Ltd Anticorps anti-il-12/il-23
WO2010022089A2 (fr) 2008-08-18 2010-02-25 University Of Maryland, Baltimore Dérivés d’apf et méthodes d’utilisation afférentes
BR122021014165B1 (pt) 2008-08-18 2022-08-16 Evogene Ltd. Método para aumentar a eficiência de uso do nitrogênio, eficiência de uso de fertilizantes, produção, biomassa e/ou tolerância ao estresse por deficiência de nitrogênio e seca de uma planta, e, construção de ácido nucleico isolado
EP2321417B1 (fr) 2008-08-20 2015-07-15 Brainco Biopharma, S.L. Stxbp1 en tant que biomarqueur psychiatrique dans un système modèle murin et ses utilisations
UA106722C2 (uk) * 2008-08-21 2014-10-10 Е. І. Дю Пон Де Немур Енд Компані Генетичні локуси, пов'язані зі стійкістю до летючої сажки у маїсу
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
ES2522346T3 (es) 2008-08-22 2014-11-14 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de CDK
EP2161345A1 (fr) 2008-08-25 2010-03-10 Institut National de la Recherche Agronomique Marqueurs génétiques pour la coloration de la viande
WO2010027870A2 (fr) * 2008-08-26 2010-03-11 Fluidigm Corporation Procédés de dosage pour un débit amélioré d'échantillons et/ou de cibles
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2010025340A2 (fr) 2008-08-29 2010-03-04 Centocor Ortho Biotech Inc. Marqueurs et procédés pour évaluer et pour traiter une recto-colite hémorragique et des troubles associés à l'aide d'un ensemble de 20 gènes
AU2009287165A1 (en) * 2008-08-29 2010-03-04 Symphogen A/S Method for cloning avian-derived antibodies
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2010026575A2 (fr) 2008-09-02 2010-03-11 Pluristem Ltd. Cellules adhérentes provenant d'un tissu placentaire et leur utilisation en thérapie
US8367392B2 (en) * 2008-09-05 2013-02-05 Transalgae Ltd. Genetic transformation of algal and cyanobacteria cells by microporation
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
US20110171649A1 (en) * 2008-09-10 2011-07-14 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US20110305682A1 (en) 2008-09-11 2011-12-15 Ben Gurion University Of The Negev Research And Development Authority Compositions and Methods for Treating S. Pneumonia Infection
TWI445716B (zh) 2008-09-12 2014-07-21 Rinat Neuroscience Corp Pcsk9拮抗劑類
EP2331703A2 (fr) * 2008-09-12 2011-06-15 Promega Corporation Determiner l'expression des genes endogenes et exogenes
EP2331679B1 (fr) 2008-09-12 2017-04-19 Cryopraxis Criobiologia LTDA. Thérapie cellulaire de tissus ischémiques
WO2010031062A1 (fr) 2008-09-15 2010-03-18 Danisco Us Inc. Production augmentée d’isoprène utilisant la voie du mévalonate inférieur archéenne
SG169640A1 (en) * 2008-09-15 2011-04-29 Danisco Us Inc Increased isoprene production using mevalonate kinase and isoprene synthase
CA2737195A1 (fr) 2008-09-15 2010-03-18 The Goodyear Tire & Rubber Company Conversion de derives de prenyle en isoprene
EP2344629B1 (fr) 2008-09-15 2018-01-24 Danisco US Inc. Systèmes utilisant une culture de cellules pour la production d isoprène
US8470581B2 (en) * 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2349549B1 (fr) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Cartouches de mélange, postes de mélange et kits, et système associé
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010033625A1 (fr) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Systèmes de manipulation de microplaques et produits-programmes informatiques et procédés connexes
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8524490B2 (en) * 2008-09-18 2013-09-03 X-Bar Diagnostic Systems, Inc. Fully automated portable DNA detection system
US20110159499A1 (en) * 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
US9127312B2 (en) 2011-02-09 2015-09-08 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
WO2010035107A2 (fr) 2008-09-24 2010-04-01 Tel Hashomer Medical Research, Infrastructure And Services Ltd. Peptides et compositions destinés à prévenir l'adhérence cellulaire et procédés d'utilisation de ceux-ci
EP2172563A1 (fr) 2008-09-24 2010-04-07 bioMérieux S.A. Procédé pour diminuer la dépendance envers la variation de séquence d'une cible d'acide nucléique dans une analyse d'hybridation de diagnostic
EP2868753A1 (fr) 2008-09-25 2015-05-06 SureGene LLC Marqueurs génétiques pour optimiser le traitement de la schizophrénie
MX2011003178A (es) 2008-09-25 2011-04-21 Danisco Inc Mezclas de alfa-amilasa y metodos para usar esas mezclas.
CN102227503B (zh) 2008-09-26 2015-10-21 托卡根公司 重组载体
US8470541B1 (en) 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
NZ591244A (en) 2008-09-29 2013-03-28 Butamax Tm Advanced Biofuels IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES
BRPI0913552B1 (pt) * 2008-09-29 2020-09-29 Butamax Advanced Biofuels Llc Método para produção de isobutanol e método para conversão de 2,3-dihidroxi isovalerato
WO2010037114A1 (fr) 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC Conversion améliorée du pyruvate en 2,3-butanediol dans des bactéries d'acide lactique
CA2736420A1 (fr) * 2008-09-29 2010-04-01 Butamaxtm Advanced Biofuels Llc Amelioration de l'activite dihydroxy-acide deshydratase dans des bacteries de l'acide lactique
MX2011003297A (es) 2008-09-29 2011-04-21 Monsanto Technology Llc Evento transgenico de frijol de soya mon87705 y metodos para deteccion del mismo.
CA2736729A1 (fr) 2008-09-29 2010-04-01 Ben Gurion University Of The Negev Research And Development Authority Beta-peptides amyloides et procedes d'utilisation associes
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US20100082438A1 (en) * 2008-10-01 2010-04-01 Ronnie Jack Garmon Methods and systems for customer performance scoring
KR101770435B1 (ko) 2008-10-03 2017-09-05 큐알엔에이, 인크. 자연 안티센스 전사체가 아포리포단백질-a1로 억제에 의해 아포리포단백-a1 관련된 질환의 치료
CA2738575C (fr) * 2008-10-03 2018-08-14 Steven Fabijanski Production d'acides gras modifies dans les vegetaux par integration ciblee d'adnr d'acides nucleiques heterogenes
CA2641132A1 (fr) * 2008-10-03 2010-04-03 Richard T. Scott, Jr. Ameliorations apportees a la fecondation in vitro
WO2010037208A1 (fr) * 2008-10-03 2010-04-08 Dow Agrosciences Llc Production de produits présentant un intérêt pharmaceutique dans des cultures de cellules végétales
RU2517615C2 (ru) * 2008-10-06 2014-05-27 Эбботт Лэборетриз Гены дельта-8-десатуразы, ферменты, кодируемые ими, и их применение
AU2009302582A1 (en) 2008-10-06 2010-04-15 University Of Chicago Compositions and methods related to bacterial Eap, Emp, and/or AdsA proteins
IL194617A0 (en) * 2008-10-07 2009-11-18 Opticul Diagnostics Ltd Device and method for spectrometric identification of antibiotic resistance microbes
US20100124756A1 (en) * 2008-10-10 2010-05-20 Sandip Ray Collection of biomarkers for diagnosis and monitoring of alzheimer's disease in body fluids
WO2010045326A1 (fr) 2008-10-14 2010-04-22 Barnes Wayne M Procédés de recombinaison in vitro utilisant une exonucléase 5’
EP2177271B8 (fr) 2008-10-15 2019-12-18 F. Hoffmann-La Roche AG Système de séparation magnétique comportant des tiges magnétiques flexibles et procédé correspontant
US9458472B2 (en) * 2008-10-15 2016-10-04 Massachusetts Institute Of Technology Detection and destruction of cancer cells using programmed genetic vectors
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100105032A1 (en) * 2008-10-23 2010-04-29 Tao Pan Highly sensitive multiplex single nucleotide polymorphism and mutation detection using real time ligase chain reaction microarray
US8058005B2 (en) 2008-10-23 2011-11-15 Honeywell International Inc. Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray
US8017327B2 (en) * 2008-10-23 2011-09-13 Honeywell International Inc. Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform
AU2009320163B2 (en) * 2008-10-27 2014-10-02 Butamax(Tm) Advanced Biofuels Llc Carbon pathway optimized production hosts for the production of isobutanol
MX345298B (es) 2008-10-30 2017-01-24 Evogene Ltd Polinucleótidos y polipéptidos aislados y métodos para utilizarlos para aumentar el rendimiento de la planta, biomasa, tasa de crecimiento, vigor, contenido de aceite, tolerancia al estrés abiótico de las plantas y eficacia en el uso de nitrógeno.
ES2705714T3 (es) 2008-10-31 2019-03-26 Janssen Biotech Inc Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones
US8498820B2 (en) * 2008-10-31 2013-07-30 Abbvie Inc. Genomic classification of non-small cell lung carcinoma based on patterns of gene copy number alterations
JP5391279B2 (ja) * 2008-10-31 2014-01-15 アッヴィ・インコーポレイテッド 1種以上の医薬組成物の有効性を試験することに使用する癌細胞系のパネルを構築するための方法
CN102203789B (zh) * 2008-10-31 2015-06-03 Abbvie公司 基于基因拷贝数改变的模式的恶性黑色素瘤的基因组分类
CA2739459A1 (fr) * 2008-10-31 2010-05-06 Abbott Laboratories Classification genomique du cancer colorectal en fonction de motifs d'alterations d'alterations du nombre de copies de gene
JP2012507986A (ja) 2008-11-03 2012-04-05 カパバイオシステムズ キメラdnaポリメラーゼ
CN102245761A (zh) 2008-11-03 2011-11-16 卡帕生物系统 修饰a型dna聚合酶
CA2742986C (fr) * 2008-11-07 2015-03-31 Triact Therapeutics, Inc. Utilisation de derives de butane catecholique dans la therapie du cancer
EP2364368B1 (fr) 2008-11-07 2014-01-15 Sequenta, Inc. Procédés de surveillance de maladies par analyse de séquence
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9095592B2 (en) 2008-11-07 2015-08-04 The Research Foundation For The State University Of New York Bruton's tyrosine kinase as anti-cancer drug target
WO2010054328A2 (fr) 2008-11-07 2010-05-14 Research Development Foundation Compositions et méthodes pour l'inhibition de la formation et de la signalisation du complexe cripto/grp78
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
EP2647692A3 (fr) * 2008-11-11 2014-01-22 The Procter and Gamble Company Compositions et procédés comprenant des variantes de sérine protéase
EP2362902B1 (fr) 2008-11-11 2012-10-24 Danisco US, Inc., Genencor Division Compositions et méthodes comportant une variante de subtilisine
KR20110095260A (ko) 2008-11-11 2011-08-24 다니스코 유에스 인크. 하나 이상의 조합가능 돌연변이를 포함하는 바실러스 서브틸리신
AR074106A1 (es) 2008-11-11 2010-12-22 Danisco Us Inc Composiciones y metodos que comprenden una variante de subtilisina
US8465964B2 (en) 2008-11-13 2013-06-18 Butamax (TM) Advanced Biofules LLC Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
US8828694B2 (en) * 2008-11-13 2014-09-09 Butamax Advanced Biofuels Llc Production of isobutanol in yeast mitochondria
WO2010055525A1 (fr) 2008-11-17 2010-05-20 Technion Research & Development Foundation Ltd. Procédé pour prédire la réactivité d'un patient à une thérapie par antifolate
WO2010058396A1 (fr) 2008-11-19 2010-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anticorps anti-cd44vra et procédés diagnostiques et thérapeutiques l'utilisant
US8288124B2 (en) * 2008-11-20 2012-10-16 Abbott Laboratories Cloning, expression and purification of recombinant porcine intrinsic factor for use in diagnostic assay
US8346485B2 (en) 2008-11-25 2013-01-01 Quest Diagnostics Investments Incorporated Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction
US9133475B2 (en) 2008-11-26 2015-09-15 Board Of Trustees Of Michigan State University Aphid resistant soybean plants
WO2010061383A1 (fr) 2008-11-26 2010-06-03 Biodalia Microbiological Technologies Ltd. Procédé permettant d’enrichir in-situ des aliments avec des fructanes
WO2010061393A1 (fr) 2008-11-30 2010-06-03 Compugen Ltd. Séquences d'acides aminés et de nucléotides de variants de he4 et leurs procédés d'utilisation
WO2010064231A1 (fr) 2008-12-02 2010-06-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Procédés d’analyse d’édition d’arn a-i et constructions d’acide nucléique capables de ceux-ci
US8652823B2 (en) * 2008-12-03 2014-02-18 Butamax(Tm) Advanced Biofuels Llc Strain for butanol production with increased membrane unsaturated trans fatty acids
US8367340B2 (en) * 2008-12-03 2013-02-05 University Of Maryland, Baltimore Prognostic tools to predict the efficacy of drug treatment targeting chromatin DNA or enzymes acting on DNA
US20120014927A1 (en) 2008-12-03 2012-01-19 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for determining predisposition to cancer
CA2745329C (fr) 2008-12-04 2022-07-12 Opko Curna, Llc Traitement de maladies liees a l'erythropoietine (epo) par inhibition d'un transcrit antisens naturel de l'epo
ES2637063T3 (es) 2008-12-04 2017-10-10 Curna, Inc. Tratamiento de enfermedades relacionadas con genes supresores de tumor mediante inhibición del transcrito antisentido natural al gen
JP5971948B2 (ja) * 2008-12-04 2016-08-17 クルナ・インコーポレーテッド Vegfに対する天然アンチセンス転写物の抑制による血管内皮増殖因子(vegf)関連疾患の治療
EP2373301B1 (fr) 2008-12-05 2013-11-06 Yeda Research and Development Co. Ltd. Procédés de diagnostic des maladies des motoneurones
WO2010068102A1 (fr) 2008-12-10 2010-06-17 Monsanto Invest N.V. Nouveau virus de plante
US20100151473A1 (en) * 2008-12-10 2010-06-17 Yeakley Joanne M Methods and compositions for hybridizing nucleic acids
WO2010068738A1 (fr) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mutations de mek conférant une résistance aux inhibiteurs de mek
EP2356198B1 (fr) 2008-12-12 2016-03-16 E. I. du Pont de Nemours and Company Procédé de fabrication d'acides dicarboxyliques linéaires à partir de ressources renouvelables
WO2010070366A1 (fr) 2008-12-15 2010-06-24 Debreceni Egyetem Procédé cytométrique servant à l'analyse comparative de la longueur des produits de pcr et utilisations du procédé
US8362318B2 (en) 2008-12-18 2013-01-29 Board Of Trustees Of Michigan State University Enzyme directed oil biosynthesis in microalgae
WO2010080388A1 (fr) 2008-12-18 2010-07-15 E. I. Du Pont De Nemours And Company Réduction des sous-produits malonates formés dans un procédé de fermentation
WO2010071610A1 (fr) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Marqueurs biologiques de chikungunya sévère
MX337685B (es) 2008-12-19 2016-03-15 Enza Zaden Beheer Bv Metodo para reproducir plantas de pepino resistentes al virus del amarilleo y enanismo de cucurbitaceas (cysdv).
US8645115B2 (en) 2008-12-22 2014-02-04 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory and logic
US8388904B1 (en) 2008-12-22 2013-03-05 Reactive Surfaces, Ltd., Llp Equipment decontamination system and method
ES2433718T3 (es) 2008-12-22 2013-12-12 University Of Utah Research Foundation PCR multiplex monocromática cuantitativa
MX340023B (es) 2008-12-29 2016-06-22 Evogene Ltd Polinucleotidos, polipeptidos codificados, y metodos para utilizarlos para aumentar la tolerancia al estres abiotico, biomasa y/o rendimiento en plantas que los expresan.
US8455225B2 (en) * 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8795992B2 (en) * 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
US8557562B2 (en) * 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
EP2808402A3 (fr) 2008-12-29 2015-03-25 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Méthodes de prédiction de la réponse au traitement par interférons
US8552147B2 (en) 2008-12-29 2013-10-08 Tel Hashomer Medical Research, Infrastructure And Services Ltd. Peptides and compositions for prevention of cell adhesion and methods of using same
WO2010078457A2 (fr) 2008-12-30 2010-07-08 Danisco Us Inc. Procédé de fabrication d'isoprène et d'un co-produit
AU2009335053B2 (en) 2008-12-30 2013-08-01 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
WO2010076794A1 (fr) 2008-12-31 2010-07-08 Technion Research & Development Foundation Ltd. Procédé pour dénitrifier une saumure et systèmes aptes à une telle dénitrification
FR2940805B1 (fr) 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
JP5818688B2 (ja) 2009-01-08 2015-11-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド 核酸増幅反応の効率を改善するための方法および組成物
US9181315B2 (en) 2009-01-08 2015-11-10 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
WO2010081001A2 (fr) 2009-01-09 2010-07-15 The Regents Of The University Of Michigan Fusions de gène récurrent dans le cancer
WO2010083456A1 (fr) 2009-01-15 2010-07-22 Imdaptive Inc. Profilage d'immunité adaptative et méthodes de génération d'anticorps monoclonaux
WO2010083051A2 (fr) 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Mélanges de tissus cartilagineux particulaires éventuellement associés à une structure spongieuse
US20100206316A1 (en) * 2009-01-21 2010-08-19 Scott Jr Richard T Method for determining chromosomal defects in an ivf embryo
CN102292349B (zh) 2009-01-22 2016-04-13 诺沃—诺迪斯克保健股份有限公司 稳定的生长激素化合物
JP5792630B2 (ja) 2009-01-28 2015-10-14 エピミューン,インコーポレイティド Pan−dr結合ポリペプチドおよびその使用
JP5715068B2 (ja) 2009-01-30 2015-05-07 マイクロニクス, インコーポレイテッド 携帯型高利得蛍光検出システム
WO2010088470A1 (fr) 2009-01-31 2010-08-05 Abbott Laboratories Marqueurs pour la prédiction et le suivi de réaction à une thérapie à base d'inhibiteurs des kinases aurora b
IL196820A0 (en) 2009-02-01 2009-11-18 Yissum Res Dev Co Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells
CN102369015A (zh) 2009-02-02 2012-03-07 雷蒙特亚特特拉维夫大学有限公司 肽、包含该肽的药物组合物及其用途
WO2010086828A2 (fr) 2009-02-02 2010-08-05 Rinat Neuroscience Corporation Anticorps monoclonaux agonistes anti-trkb
WO2010091111A1 (fr) 2009-02-03 2010-08-12 Biohelix Corporation Amplification dépendante d'une hélicase améliorée par une endonucléase
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
WO2010089707A1 (fr) 2009-02-04 2010-08-12 Yeda Research And Development Co. Ltd. Procédé et trousses pour déterminer la sensibilité ou la résistance d'un cancer prostatique à une radiothérapie
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
US9045800B2 (en) * 2009-02-11 2015-06-02 Abbvie Inc. Methods and compositions for identifying, classifying and monitoring subject having Bcl-2 family inhibitor-resistant tumors and cancers
EP3301446B1 (fr) 2009-02-11 2020-04-15 Caris MPI, Inc. Profilage moléculaire de tumeurs
CA2751758A1 (fr) 2009-02-11 2010-08-19 Orion Genomics Llc Combinaisons de polymorphismes destinees a determiner l'expression specifique des alleles d'igf2
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
DK2396011T3 (en) 2009-02-12 2016-04-25 Janssen Biotech Inc Fibronectin TYPE III DOMAIN-BASED SCAFFOLD COMPOSITIONS, METHODS AND USES
PL2396038T3 (pl) 2009-02-12 2016-05-31 Curna Inc Leczenie chorób związanych z neurotropowym czynnikiem pochodzenia mózgowego (bdnf) poprzez zahamowanie naturalnego antysensownego transkryptu bdnf
EP2218794A1 (fr) 2009-02-13 2010-08-18 Alphagenics International SA Détection de l'instabilité dans les régions d'ADN génomique contenant des répétitions à tandem simple
US8409805B2 (en) 2009-02-13 2013-04-02 Asuragen, Inc. Method of amplification of GC-rich DNA templates
US9399219B2 (en) 2009-02-13 2016-07-26 Frank Leo Spangler Thermal Array
WO2010094061A1 (fr) 2009-02-17 2010-08-26 Murdoch Childrens Research Institute Dosage permettant de déterminer les profils épigénétiques des marqueurs d'allèles de l'x fragile
AU2010217928B2 (en) 2009-02-26 2013-06-06 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
WO2010099500A2 (fr) 2009-02-26 2010-09-02 Codexis, Inc. Enzymes variantes de la bêta-glucosidase et polynucléotides associés
US8828722B2 (en) 2009-02-26 2014-09-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
US8642834B2 (en) 2009-02-27 2014-02-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
WO2010099138A2 (fr) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Procédés pour l'identification d'agents qui inhibent les cellules tumorales de type mésenchymateuses ou leur formation
AU2010220157C1 (en) 2009-03-02 2015-08-06 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
US20110171749A1 (en) * 2009-03-02 2011-07-14 Board Of Trustees Of Michigan State University Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt)
SG10201704868RA (en) 2009-03-06 2017-07-28 Synthetic Genomics Inc Methods For Cloning And Manipulating Genomes
ES2564265T3 (es) 2009-03-09 2016-03-21 Ramot At Tel-Aviv University Ltd. Composiciones para prevención y tratamiento de enfermedades neurodegenerativas
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
US20120107267A1 (en) 2009-03-11 2012-05-03 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
CA2755207A1 (fr) 2009-03-12 2010-09-16 Brandeis University Reactifs et procedes pour pcr
WO2010103517A1 (fr) 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Compositions solubles pour le traitement de maladies associées aux ligands cxcr3
AU2010226726B8 (en) 2009-03-16 2014-08-14 Pangu Biopharma Limited Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
MX2011009751A (es) 2009-03-16 2011-09-29 Opko Curna Llc Tratamiento de enfermedades relacionadas con factor nuclear (eritroide derivado 2) tipo 2 (nrf2) por inhibicion del transcrito antisentido natural a nrf2.
EP2408863B1 (fr) 2009-03-16 2018-01-10 Promega Corporation Colorants de liaison d'acides nucléiques et leurs utilisations
CA2754580C (fr) 2009-03-17 2014-06-17 Codexis, Inc. Variantes d'endoglucanases et polynucleotides connexes
WO2010107740A2 (fr) 2009-03-17 2010-09-23 Curna, Inc. Traitement des maladies associées à l'homologue du delta-like 1 (dlk1) par inhibition du transcrit antisens naturel de dlk1
SI3260136T1 (sl) 2009-03-17 2021-05-31 Theraclone Sciences, Inc. Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa
US20100279295A1 (en) * 2009-03-18 2010-11-04 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
US8481698B2 (en) * 2009-03-19 2013-07-09 The President And Fellows Of Harvard College Parallel proximity ligation event analysis
EP3192871B1 (fr) 2009-03-19 2019-01-23 DSM IP Assets B.V. Molécules d'acide nucléique et polypeptides d'acide gras polyinsaturé synthase, compositions et procédés de préparation et leurs utilisations
KR101800833B1 (ko) 2009-03-20 2017-11-23 씨엘에스엔 래버러토리스, 인코퍼레이티드 폴리아민 유도체
EP3415235A1 (fr) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation de gouttelettes microfluidiques
GB0904957D0 (en) 2009-03-23 2009-05-06 Univ Erasmus Medical Ct Tumour gene profile
US20110045080A1 (en) * 2009-03-24 2011-02-24 William Marsh Rice University Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
US20100248239A1 (en) * 2009-03-24 2010-09-30 Mayo Foundation For Medical Education And Research Methods and materials for detecting fragile x mutations
CN102449171B (zh) 2009-03-24 2015-12-02 奥斯瑞根公司 对fmr1和fmr2基因5’非翻译区进行表征的pcr方法
US20120114618A1 (en) 2009-03-26 2012-05-10 The Regents Of The University Of California Mesenchymal Stem Cells Producing Inhibitory RNA for Disease Modification
CA2756760A1 (fr) 2009-03-27 2010-11-04 Gojo Industries, Inc. Compositions et procedes pour cribler et utiliser des composes antagonistes des interactions spore-surface
US8741311B2 (en) 2009-03-27 2014-06-03 Academia Sinica Methods and compositions for immunization against virus
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
PT2414517T (pt) 2009-03-30 2016-12-27 Portola Pharm Inc Antídotos para inibidores do fator xa e métodos de utilização dos mesmos
GB0905325D0 (en) 2009-03-30 2009-05-13 Selex Sensors & Airborne Sys Detection system
EP2414542B1 (fr) 2009-03-30 2017-08-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Méthodes pour prévoir l'évolution clinique de la sclérose en plaque et la traiter
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2010117620A2 (fr) 2009-03-30 2010-10-14 Illumina, Inc. Analyse de l'expression génétique dans des cellules individuelles
EP2414541B8 (fr) 2009-03-31 2014-09-10 Centre Hospitalier Universitaire Vaudois Macropuce pour l'identification de méthylations dépendante d'une ligature (mlm)
CA2757289A1 (fr) 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions et procedes impliquant des aspartyl-arnt synthetases presentant des activites biologiques non canoniques
BRPI1010239A2 (pt) 2009-03-31 2016-10-11 Codexis Inc endoglucanases aprimoradas, derivados e seus usos
MX2011010401A (es) 2009-04-01 2012-01-20 Rappaport Family Inst Res In The Medical Sciences Un metodo para regular la proliferacion y deferenciacion de queratinocitos.
US20120045822A1 (en) 2009-04-01 2012-02-23 Danisco Us Inc. Cleaning System Comprising An Alpha-Amylase And A Protease
EP2789694A1 (fr) 2009-04-02 2014-10-15 Fluidigm Corporation Dispositif microfluidique avec système de récupération de produit de réaction
WO2011005341A2 (fr) 2009-04-03 2011-01-13 University Of Chicago Compositions et méthodes associées aux variants de la protéine a (spa)
US20100279299A1 (en) * 2009-04-03 2010-11-04 Helixis, Inc. Devices and Methods for Heating Biological Samples
WO2011127032A1 (fr) 2010-04-05 2011-10-13 University Of Chicago Compositions et procédés liés aux anticorps de la protéine a (spa) en tant que amplificateur de la réponse immunitaire
EP3211095B1 (fr) 2009-04-03 2019-01-02 Sequenom, Inc. Compositions et procédés de préparation d'acides nucléiques
WO2010116375A1 (fr) 2009-04-08 2010-10-14 Yeda Research And Development Co. Ltd. Peptides isolés pour réguler l'apoptose
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
US20100272824A1 (en) * 2009-04-16 2010-10-28 The Texas A&M University System Compositions and methods for preventing and monitoring disease
EP2272327A1 (fr) 2009-04-16 2011-01-12 Schillinger Genetics, Inc. Soja doté de taux de germination élevés et une teneur très faible en raffinose et en stachyose
CN107243076A (zh) 2009-04-22 2017-10-13 印第安那大学科技研究公司 用于治疗慢性阻塞性肺病和哮喘的组合物和方法
US8518686B2 (en) * 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US20120100997A1 (en) 2009-04-24 2012-04-26 University Of Southern California Cd133 polymorphisms and expression predict clinical outcome in patients with cancer
EP2421969B1 (fr) 2009-04-24 2015-10-21 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Détection sélective d'espèces de bordetella
GB0908770D0 (en) 2009-04-24 2009-07-01 Danisco Method
EP2256215A1 (fr) 2009-04-30 2010-12-01 Steffen Mergemeier Système d'analyse utilisant une activité de nucléase d'une polymérase d'acide nucléique
WO2010126614A2 (fr) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Procédés et compositions d'évaluation de marqueurs génétiques
PT2424896E (pt) 2009-04-30 2015-11-30 Univ Ramot Anticorpos anti-ceacam1 e métodos de utilização dos mesmos
WO2010128016A2 (fr) 2009-05-04 2010-11-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Agonistes du récepteur par2 utilisés dans le traitement ou la prévention des infections du virus de la grippe a
MX348013B (es) 2009-05-05 2017-05-23 Novimmune Sa Anticuerpos anti il-17f y metodos de uso de los mismos.
CA2761142C (fr) 2009-05-06 2021-06-08 Opko Curna, Llc Traitement de maladies liees a la tristetraproline (ttp) par l'inhibition d'un transcrit antisens naturel de ttp
US9155754B2 (en) 2009-05-06 2015-10-13 Curna, Inc. Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1
EP2249140B1 (fr) 2009-05-07 2018-06-27 F. Hoffmann-La Roche AG Procédé d'extraction d'échantillons biologiques sur un support solide
JP5931720B2 (ja) 2009-05-08 2016-06-08 クルナ・インコーポレーテッド Dmdファミリーに対する天然アンチセンス転写物の抑制によるジストロフィンファミリー関連疾患の治療
US20110039307A1 (en) * 2009-05-12 2011-02-17 Henderson Jodi M Ethanol yields in fermentation from an improved liquefaction process
US20100291606A1 (en) * 2009-05-13 2010-11-18 Board Of Regents, The University Of Texas System SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION
WO2010132604A2 (fr) 2009-05-13 2010-11-18 Sea Lane Biotechnologies, Llc Molécules neutralisantes dirigées contre les virus de la grippe
US20100291536A1 (en) * 2009-05-14 2010-11-18 Streck, Inc. Sample processing cassette, system, and method
US8329636B2 (en) 2009-05-14 2012-12-11 Arizona Board Of Regents On Behalf Of University Of Arizona Carcinoma diagnosis and treatment, based on ODC1 genotype
WO2010132888A2 (fr) 2009-05-15 2010-11-18 Insight Genetics, Inc. Méthodes et compositions associés à des fusions de la kinase alk pour diagnostiquer et traiter le cancer
ES2664590T3 (es) 2009-05-18 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con factores de reprogramación por inhibición del tránscrito antisentido natural a un factor de reprogramación
US20120058222A1 (en) 2009-05-19 2012-03-08 Danisco A/S Use
US20100297072A1 (en) * 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
US9182403B2 (en) 2009-05-19 2015-11-10 Zetiq Technologies Ltd. Kits for and methods of differential staining of cervical cancer cells and/or tissues
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
CA2762302A1 (fr) 2009-05-20 2010-11-25 Theraclone Sciences, Inc. Compositions et procedes pour le traitement et le diagnostic de la grippe
CA2763283C (fr) 2009-05-21 2021-01-12 Verenium Corporation Phytases, acides nucleiques codant pour elles et procedes de fabrication et d'utilisation associes
CN102549158B (zh) 2009-05-22 2017-09-26 库尔纳公司 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病
EP2432899A1 (fr) 2009-05-22 2012-03-28 Population Genetics Technologies LTD. Tri d'acides nucléiques asymétriquement marqués par extension d'amorce sélective
GB0908905D0 (en) 2009-05-26 2009-07-01 Sentinel Oncology Ltd Pharmaceutical compounds
US20120078163A1 (en) 2009-05-27 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2010137013A1 (fr) 2009-05-27 2010-12-02 Ramot At Tel Aviv University Ltd. Unités cristallisées de photosystème i dérivées du pois et leur utilisation dans des dispositifs solides
US20120083477A1 (en) 2009-05-27 2012-04-05 Yeda Research And Development Co. Ltd. Proteasome inhibitors and uses thereof
US8791085B2 (en) 2009-05-28 2014-07-29 Curna, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
EP2435078A1 (fr) 2009-05-28 2012-04-04 Yeda Research and Development Co. Ltd. Méthodes de traitement d'inflammation
WO2010136232A1 (fr) 2009-05-28 2010-12-02 Fundació Institut De Recerca De L´Hospital Universitari Vall D'hebron Procédé in vitro approprié pour des patients souffrant d'un syndrome clinique isolé pour le diagnostic précoce ou le pronostic de la sclérose en plaques
EP3301104B1 (fr) 2009-05-29 2019-10-30 Life Technologies Corporation Particules de polymère d'acide nucléique échafaudées et procédés de fabrication et d'utilisation
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120142544A1 (en) 2009-06-02 2012-06-07 University Of Miami Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies
KR101252507B1 (ko) * 2009-06-05 2013-04-09 가톨릭대학교 산학협력단 실시간 중합효소연쇄반응을 이용한 hla 대립유전자 자동검사 키트
DK2548950T3 (en) 2009-06-05 2017-12-11 Cellular Dynamics Int Inc Reprogramming of T cells and hematopoietic cells
DK3276004T3 (da) 2009-06-08 2020-04-06 Quark Pharmaceuticals Inc Fremgangsmåder til behandling af kronisk nyresygdom
EP2264183B1 (fr) 2009-06-09 2016-12-07 Gendiag.exe, S.L. Marqueurs de risque pour maladie cardiovasculaire
US9096865B2 (en) 2009-06-10 2015-08-04 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance
EP2261242A1 (fr) 2009-06-10 2010-12-15 Universite Catholique De Louvain Enzyme aspartate-N-acétyltransférase, procédé de diagnostic et procédé thérapeutique
EP2440922B1 (fr) 2009-06-12 2016-08-10 Vaccine Technologies, Incorporated Procédé pour essais diagnostiques de mesure d'une response immunitaire à médiation cellulaire
CN102573883A (zh) 2009-06-12 2012-07-11 疫苗技术公司 用于促进细胞-介导的免疫应答的方法和组合物
US20100317916A1 (en) * 2009-06-12 2010-12-16 Scott Jr Richard T Method for relative quantitation of chromosomal DNA copy number in single or few cells
AR077042A1 (es) 2009-06-12 2011-07-27 Danisco Metodo para tratar una composicion que contiene pirofiofitina
CN102803506A (zh) 2009-06-15 2012-11-28 Bg研究有限公司 核酸检测
US8951981B2 (en) 2009-06-16 2015-02-10 Curna, Inc. Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
BRPI1012922A2 (pt) 2009-06-16 2016-10-11 Codexis Inc polipeptídeo de b-glicosidase variante, vetor de expressão, célula hospedeira, método de produção de polipeptídeo de b-glicosidase variante, composição enzimática, método de conversão de um substrato de biomassa em açucar fermentável e método de produção de álcool
CA2763424C (fr) 2009-06-16 2018-06-12 E.I. Du Pont De Nemours And Company Amelioration de la biosynthese d'acide gras omega-3 et omega-6 polyinsature a chaine longue par l'expression d'acyl-coa lysophospholipide acyltransferase
BRPI1010696A2 (pt) 2009-06-16 2016-10-11 Codexis Inc método de produção de um polipeptídeo de b-glicosidade com termoatividade aperfeiçoada, polipeptídeo, proteína e seus usos
US9050276B2 (en) 2009-06-16 2015-06-09 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
US20120171170A1 (en) 2009-06-16 2012-07-05 Opko Curna, Llc Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
TW201412988A (zh) * 2009-06-17 2014-04-01 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
WO2010146511A1 (fr) 2009-06-17 2010-12-23 Pfizer Limited Traitement d'une vessie hyperactive
TW201120213A (en) 2009-06-17 2011-06-16 Danisco Us Inc Polymerization of isoprene from renewable resources
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
RU2011151287A (ru) 2009-06-18 2013-07-27 Пфайзер Инк. АНТИ Notch-1 АНТИТЕЛА
US20120110703A1 (en) 2009-06-19 2012-05-03 Kirin Holdings Kabushiki Kaisha Protein having novel prenyltransferase activity and gene encoding the same
EP2264184A1 (fr) 2009-06-22 2010-12-22 Qiagen GmbH Procédé d'amplification d'ADN en utilisant du tétraéthylèneglycole, coffret de pièces correspondant et son utilisation
EP3450573B1 (fr) 2009-06-23 2022-01-26 Gen-Probe Incorporated Composition et procédés permettant de détecter un acide nucléique à partir de mollicutes
CA2765779A1 (fr) 2009-06-24 2010-12-29 Fund For Medical Research Development Of Infrastructure And Health Servi Ces - At Rambam Medical Center Methodes et kits d'isolement de microparticules placentaires et utilisation dans le diagnostic des affections placentaires
US20120283136A1 (en) 2009-06-24 2012-11-08 The University Of Southern California Compositions and methods for the rapid biosynthesis and in vivo screening of biologically relevant peptides
WO2010151671A2 (fr) 2009-06-24 2010-12-29 Curna, Inc. Traitement de maladies associées au récepteur de facteur nécrosant des tumeurs 2 (tnfr2) par inhibition de la transcription antisens naturelle de tnfr2
NZ597118A (en) 2009-06-25 2013-10-25 Dupont Nutrition Biosci Aps A method for increased expression of a variant lipolytic enzyme
RU2539032C2 (ru) 2009-06-25 2015-01-10 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения искусственного иммунитета
US20120156676A1 (en) 2009-06-25 2012-06-21 Weidhaas Joanne B Single nucleotide polymorphisms in brca1 and cancer risk
US8921330B2 (en) 2009-06-26 2014-12-30 Curna, Inc. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
US20120142609A1 (en) 2009-06-26 2012-06-07 Abdoulaye Sene Non human animal models for increased retinal vascular permeability
US9260475B2 (en) 2009-06-26 2016-02-16 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
WO2010151808A1 (fr) 2009-06-26 2010-12-29 Sea Lane Biotechnologies, Llc Expression de chaînes légères substituts
EP2789689B1 (fr) 2009-06-29 2016-04-27 Luminex Corporation Amorces chimères avec des conformations en épingle à cheveux et leurs procédés d'utilisation
JP2012532190A (ja) 2009-06-30 2012-12-13 アボット ラボラトリーズ Xmrv感染のマーカーとその使用
EP2272979A1 (fr) 2009-06-30 2011-01-12 Centre National de la Recherche Scientifique (CNRS) Procédé de test d'un sujet dont on pense qu'il est prédisposé à un cancer
US8512955B2 (en) 2009-07-01 2013-08-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
WO2011000107A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Formulations lipidiques inédites permettant l'administration d'agents thérapeutiques en direction de tumeurs solides
IN2012DN00462A (fr) 2009-07-02 2015-06-05 Verdezyne Inc
EP2451969A2 (fr) 2009-07-07 2012-05-16 University Of Southern California Biomarqueurs pour la détection précoce de maladies auto-immunes
WO2011006136A2 (fr) * 2009-07-09 2011-01-13 Verdezyne, Inc. Micro-organismes modifiés ayant une activité de fermentation améliorée
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
EP2272980A1 (fr) 2009-07-09 2011-01-12 Bioesplora SRL Sondes moléculaires pour la détection et la quantification d'acides nucléiques cibles
WO2011004379A1 (fr) 2009-07-10 2011-01-13 Tel Hashomer Medical Research Infrastructure And Services Ltd. Compositions et méthodes de traitement du cancer
CA2767858C (fr) 2009-07-15 2019-02-12 Portola Pharmaceuticals, Inc. Formulation de dose unique d'antidotes pour des inhibiteurs de facteur xa et procedes d'utilisation de celle-ci
ES2707590T3 (es) 2009-07-15 2019-04-04 Zhenglun Zhu Gestión del tratamiento de trastornos inflamatorios o autoinmunitarios usando expresión de Hom-1
US8188335B2 (en) 2009-07-17 2012-05-29 Abbott Laboratories Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
EP2454000A4 (fr) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systèmes pour l'identification d'un bioagent
SG10201700096VA (en) 2009-07-17 2017-02-27 Bioatla Llc Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
KR101870378B1 (ko) 2009-07-17 2018-06-25 릭스하스피탈렛 보체 활성화의 억제제로서의 masp 이소형
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
EP3330385A1 (fr) 2009-07-21 2018-06-06 Gen-Probe Incorporated Procédés et compositions pour la détection quantitative de séquences d'acides nucléiques sur une plage dynamique étendue
WO2011010309A1 (fr) 2009-07-21 2011-01-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. Méthode de diagnostic du cancer
BR112012001411A2 (pt) 2009-07-22 2019-09-24 Du Pont sequencias e seu uso para detecção e caracterização de e. coli 0157:h7
WO2011009883A1 (fr) 2009-07-23 2011-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Agonistes sélectifs du récepteur cb2 destinés à être utilisés dans la prévention ou le traitement d'une maladie hépatique alcoolique
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
JP2013500017A (ja) 2009-07-24 2013-01-07 カッパーアールエヌエー,インコーポレイテッド サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療
GB0913442D0 (en) 2009-07-31 2009-09-16 Univ Ramot Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
EP2462229B1 (fr) 2009-08-05 2016-05-11 CuRNA, Inc. Traitement de maladies liées à un gène de l insuline (ins) par inhibition du transcrit antisens naturel d'un gène de l'insuline (ins)
WO2011017567A1 (fr) 2009-08-05 2011-02-10 Life Technologies Corporation Procédés d'analyse de données de test de fixation à proximité
WO2011017492A2 (fr) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Nouveaux gènes eto1 et leur utilisation pour une teneur en éthylène réduite et une tolérance au stress améliorée chez les plantes
CN102612376A (zh) 2009-08-06 2012-07-25 诺沃-诺迪斯克保健股份有限公司 具有延长的体内功效的生长激素
WO2011019393A2 (fr) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci
CA2770104C (fr) 2009-08-11 2019-03-19 Opko Curna, Llc Traitement de maladies associees a l'adiponectine (adipoq) par inhibition du produit de transcription anti-sens naturel d'une adiponectine (adipoq)
EP2789693B1 (fr) 2009-08-13 2017-10-04 Life Technologies Corporation SNP d'amélogénine sur chromosome X
EP2467470A2 (fr) 2009-08-17 2012-06-27 Technion Research & Development Foundation Ltd. Cellules progénitrices de péricyte et leurs procédés de génération et d'utilisation
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
US20110045053A1 (en) * 2009-08-18 2011-02-24 Shen Michael M Isolated population of luminal stem cells that give rise to prostate cancer and methods of using same
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US20110045458A1 (en) * 2009-08-20 2011-02-24 Mayo Foundation For Medical Education And Research Detection of Enterovirus
WO2011021102A2 (fr) 2009-08-20 2011-02-24 Population Genetics Technologies Ltd Compositions et procédés de réarrangement d'acide nucléique intramoléculaire
BR112012008054A2 (pt) * 2009-08-21 2017-05-23 Gilead Biologics Inc domínios catalíticos de lisil oxidase e loxl2
CA2771786A1 (fr) * 2009-08-21 2011-02-24 Gilead Biologics, Inc. Essais de criblage in vivo
US20110044907A1 (en) * 2009-08-21 2011-02-24 Derek Marshall In vivo screening assays
PT2467140T (pt) 2009-08-21 2016-08-30 Novartis Ag Lapatinib para tratamento do cancro
JP2013502228A (ja) * 2009-08-21 2013-01-24 ギリアド バイオロジクス,インク. invitroスクリーニングアッセイ
US8481267B2 (en) * 2009-08-21 2013-07-09 E. I. Du Pont De Nemours And Company Genetic fingerprinting and identification method
BR112012008084A2 (pt) * 2009-08-21 2019-09-24 Gilead Biologics Inc método terapêuticos e composições.
CN102481311A (zh) 2009-08-21 2012-05-30 比欧洛吉科斯公司 经由植物转录的分子预防和治疗有益昆虫的疾病
EP2467482A4 (fr) 2009-08-21 2013-12-11 Curna Inc Traitement des maladies liées à « l'extrémité c de la protéine chip (protéine interagissant avec hsp70) » par inhibition du transcrit antisens naturel de chip
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
CA2770389C (fr) 2009-08-25 2015-12-29 Illumina, Inc. Procedes de selection et d?amplification de polynucleotides
WO2011031482A2 (fr) 2009-08-25 2011-03-17 Curna, Inc. Traitement de maladies associées à la protéine d'activation de gtpase contenant un motif iq (iqgap), par inhibition d'un transcrit antisens naturel de iqgap
WO2011025826A1 (fr) 2009-08-26 2011-03-03 Research Development Foundation Procédés pour créer des banques d'anticorps
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
CN106619515A (zh) 2009-08-27 2017-05-10 工业研究与发展基金会有限公司 脂质体组合物及其用途
US9598699B2 (en) 2009-08-28 2017-03-21 Kirin Holdings Kobushiki Kaisha Protein having glycoalkaloid biosynthetic enzyme activity and gene encoding the same
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
CA2771769C (fr) 2009-08-28 2019-10-29 Research Development Foundation Analogues d'urocortine 2 et leurs utilisations
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
TW201113523A (en) * 2009-08-31 2011-04-16 Mbio Diagnostics Inc Integrated sample preparation and analyte detection
JP6057460B2 (ja) 2009-08-31 2017-01-11 ジェン−プローブ・インコーポレーテッド デングウイルスアッセイ
CA2772123C (fr) 2009-08-31 2018-03-06 The Governors Of The University Of Alberta Systeme de detection en epingle a cheveux induite par liaison
WO2011027966A2 (fr) 2009-09-03 2011-03-10 Seegene, Inc. Sonde td et ses utilisations
CA2772859C (fr) 2009-09-04 2015-05-26 Codexis, Inc. Cellulases cbh2 variantes et polynucleotides apparentes
EP2294912A1 (fr) 2009-09-04 2011-03-16 Wageningen Universiteit Procédé pour augmenter le taux de zéaxanthine dans une lignée végétale, procédé de sélection d'une plante ou d'une partie de celle-ci, y compris la graine et le tubercule, et utilisations correspondantes
US8889394B2 (en) * 2009-09-07 2014-11-18 Empire Technology Development Llc Multiple domain proteins
WO2011030332A2 (fr) 2009-09-08 2011-03-17 Yeda Research And Development Co. Ltd. Procédés pour la mobilisation de précurseur hématopoïétique
EP2475784A1 (fr) 2009-09-08 2012-07-18 Ramot at Tel-Aviv University Ltd. Procédés de diagnostic de la sclérose latérale amyotrophique (sla)
WO2011031377A1 (fr) * 2009-09-09 2011-03-17 Helixis, Inc. Systèmes optiques pour réactions multiples
WO2011032040A1 (fr) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Procédés de séquençage ciblé
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
WO2011030329A1 (fr) 2009-09-10 2011-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthode de traitement de tumeurs
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
CN107303302A (zh) 2009-09-14 2017-10-31 希拉金股份有限公司 溶瘤牛痘病毒组合癌症疗法
EP2478093A2 (fr) 2009-09-17 2012-07-25 Yeda Research and Development Co. Ltd. Polypeptides pon1 isolés, polynucléotides codant pour ceux-ci et utilisations de ceux-ci dans le traitement ou la prévention des dommages associés à l'exposition à un organophosphate
JP5800817B2 (ja) 2009-09-17 2015-10-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
US8735124B2 (en) 2009-09-17 2014-05-27 Yeda Research And Development Co. Ltd. Isolated PON1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
JP2013505230A (ja) 2009-09-17 2013-02-14 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド 酸化ストレス関連障害を処置するためのペプチド
KR101856055B1 (ko) 2009-09-18 2018-05-09 파이코일 바이오테크놀로지 인터내셔널, 아이엔씨. 조절되는 조명을 사용하는 미세조류 발효
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
US20110070590A1 (en) 2009-09-22 2011-03-24 Jan Rohozinski Primers and Methods for Determining RhD Zygosity
US9808504B2 (en) 2009-09-22 2017-11-07 Yale University Immunogenic epitopes as targets for universal cancer vaccines
CA2775092A1 (fr) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions et procedes pour reduire au silence des genes exprimes dans le cancer
JP5681719B2 (ja) 2009-09-24 2015-03-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル タウ機能不全を伴う神経障害を処置するための新規な治療ターゲットとしてのfkbp52−タウ相互作用
WO2011038360A1 (fr) 2009-09-25 2011-03-31 Signature Genomics Laboratories Llc Réseaux à brins multiplexes (+/-) et essais pour détecter des anomalies chromosomiques associées au cancer et autres maladies
JP6175236B2 (ja) 2009-09-25 2017-08-09 カッパーアールエヌエー,インコーポレイテッド フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置
WO2011037802A2 (fr) 2009-09-28 2011-03-31 Igor Kutyavin Procédés et compositions pour la détection d'acides nucléiques en se basant sur des complexes de sondes à oligonucléotides stabilisés
BR112012006939A2 (pt) * 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides
CA2775892A1 (fr) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Production fermentative d'isobutanol a l'aide de ceto-acide reducto-isomerases a efficacite elevee
US9169499B2 (en) * 2009-09-29 2015-10-27 Butamax Advanced Biofuels Llc Flux to acetolactate-derived products in lactic acid bacteria
WO2011041594A1 (fr) 2009-09-30 2011-04-07 Codexis, Inc. C1 β-glycosidase recombinante pour la production de sucres à partir d'une biomasse cellulosique
CN104826106B (zh) 2009-09-30 2019-01-11 斯隆凯特林防癌纪念中心 用于治疗癌症的组合免疫疗法
CA2776173A1 (fr) 2009-09-30 2011-04-07 Nicholas Marini Cofacteurs et procedes d'utilisation chez des sujets
EP2483404A1 (fr) 2009-10-02 2012-08-08 Pioneer Hi-Bred International Inc. Régulation à la baisse de l'acc synthase pour améliorer le rendement de plantes
MX342640B (es) 2009-10-02 2016-10-07 Syngenta Participations Ag Proteinas insecticidas.
US20110081706A1 (en) * 2009-10-02 2011-04-07 TransAlgae Ltd Method and system for efficient harvesting of microalgae and cyanobacteria
US8962251B2 (en) * 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
TW201118178A (en) * 2009-10-09 2011-06-01 Baylor Res Inst Identification of micrornas (miRNAs) in fecal samples as biomarkers for gastroenterological cancers
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
MX353880B (es) 2009-10-14 2018-01-31 Yissum Research Development Company Of The Hebrew Univ Of Jerusalem Ltd Star Composiciones para controlar ácaros varroa en abejas.
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
US9029088B2 (en) 2009-10-15 2015-05-12 Life Technologies Corporation Human single nucleotide polymorphisms within CODIS loci D13S317, TH01, vWA, D12S391, and D6S1043
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
DK2488873T3 (en) 2009-10-16 2015-11-09 Novartis Ag Biomarkers for pharmacodynamic tumor responses
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
US8975019B2 (en) * 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
WO2011049439A1 (fr) 2009-10-19 2011-04-28 Universiteit Twente Procédé pour sélectionner des cellules souches mésenchymateuses formatrices d'os
EP2490696A1 (fr) 2009-10-20 2012-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement des troubles de l'homéostasie du glucose
US20120282230A1 (en) 2009-10-21 2012-11-08 Kimberly Drenser Methods and compositions for diagnosis and treatment of genetic and retinal disease
WO2011048600A1 (fr) 2009-10-21 2011-04-28 Danziger Innovations Ltd. Génération de variations génotypiques dans des génomes de plantes par infection d'un gamète
IN2012DN02587A (fr) 2009-10-22 2015-08-28 Biotools Biotechnological & Medical Lab S A
TWI483736B (zh) 2009-10-23 2015-05-11 Millennium Pharm Inc 抗-gcc抗體分子及其相關之組合物及方法
US8440406B2 (en) * 2009-10-23 2013-05-14 Luminex Corporation Amplification primers with non-standard bases for increased reaction specificity
CN102666849A (zh) 2009-10-26 2012-09-12 斯泰伦博斯大学 真菌纤维二糖水解酶2基因在酵母中的异源表达
CA2777169C (fr) 2009-10-26 2018-11-20 Abbott Laboratories Methodes de diagnostic permettant d'etablir un pronostic en cas de cancer du poumon non a petites cellules
EP2494071A1 (fr) * 2009-10-26 2012-09-05 Abbott Laboratories Procédés de diagnostic pour déterminer le pronostic d'un cancer du poumon non à petites cellules
EP2494077A4 (fr) 2009-10-27 2013-08-21 Caris Mpi Inc Profilage moléculaire pour médecine personnalisée
KR20240007725A (ko) 2009-11-02 2024-01-16 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료학적 뉴클레아제 조성물 및 방법
WO2011056872A2 (fr) 2009-11-03 2011-05-12 Gen9, Inc. Procédés et dispositifs microfluidiques pour la manipulation de gouttelettes dans un ensemble polynucléotidique haute fidélité
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
WO2011055232A2 (fr) 2009-11-04 2011-05-12 Population Genetics Technologies Ltd. Criblage de mutation base par base
US20120282276A1 (en) 2009-11-05 2012-11-08 The Regents Of The University Of Michigan Biomarkers predictive of progression of fibrosis
EP2501398A1 (fr) 2009-11-06 2012-09-26 INSERM - Institut National de la Santé et de la Recherche Médicale Procédés et composition pharmaceutique destinés au traitement de l'athérosclérose
KR20120117746A (ko) 2009-11-06 2012-10-24 엔지메틱스, 인코포레이티드. 열 안정성 중합효소와 이중 가닥 핵산 복합체를 사용하여 디옥시리보뉴클레오티드 사슬을 합성하는 조성물 및 이들의 합성방법
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Thd 프라이머 타겟 검출
IL201999A (en) 2009-11-08 2017-10-31 Medical Res & Development Fund For Health Services Bnai Zion Medical Center The State Of Israel A knockout mouse of the 1 – mo gene, a gene associated with morbidly extreme obesity
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
JP6276918B2 (ja) 2009-11-12 2018-02-07 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 多能性幹細胞を未分化状態で培養する培地、細胞培養および方法
EP2498806B1 (fr) 2009-11-12 2014-12-31 Ramot at Tel-Aviv University Ltd. Compositions contenant du pedf et leurs utilisations dans le traitement et la prévention de syndromes liés aux ovaires
WO2011058555A1 (fr) 2009-11-12 2011-05-19 Yeda Research And Development Co. Ltd. Procédé d'édition de l'adn dans une cellule et constructions ayant cette capacité
WO2011060014A1 (fr) 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Essais de détection de petits arn
CA3061784C (fr) 2009-11-13 2023-09-26 Dana-Farber Cancer Institute, Inc. Compositions, kits et methodes utilises pour le diagnostic, le pronostic, la surveillance, le traitement et la modulation des lymphoproliferations apres greffe d'organe et de l'hy poxie associee a l'angiogenese au moyen de la galectine-1
EP2335717A1 (fr) 2009-11-16 2011-06-22 Institut National De La Recherche Agronomique Antagonistes PAR-1 pour une utilisation dans le traitement ou la prévention d'infections par le virus de la grippe de type A
GB0920089D0 (en) 2009-11-17 2009-12-30 Danisco Method
US20120230974A1 (en) 2009-11-17 2012-09-13 Protalix Ltd Alkaline alpha galactosidase for the treatment of fabry disease
EP2501414B1 (fr) 2009-11-17 2018-01-10 The Trustees Of The University Of Pennsylvania Dégron smndelta7 : nouvelles compositions et procédés d'utilisation
EP2905332B1 (fr) 2009-11-19 2018-09-12 Solis BioDyne OÜ Compositions permettant d'augmenter la stabilité et l'activité de polypeptides, procédés associés
WO2011063198A2 (fr) 2009-11-20 2011-05-26 St. Jude Children's Research Hospital Procédés et compositions de modulation de l'activité du complexe du récepteur de l'interleukine 35
US20110154541A1 (en) * 2009-11-24 2011-06-23 Technion Research And Development Foundation Ltd. Bio-engineered photosystems
EP2504472A1 (fr) 2009-11-24 2012-10-03 Collplant Ltd. Procédé de production de fibres de collagène
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
CA2781884C (fr) 2009-11-25 2015-01-20 Codexis, Inc. Variants recombines de la beta-glucosidase destines a produire des sucres solubles a partir d'une biomasse cellulosique
WO2011064282A1 (fr) 2009-11-25 2011-06-03 Novo Nordisk A/S Procédé de production de polypeptides
NZ599237A (en) 2009-11-26 2014-03-28 Quark Pharmaceuticals Inc Sirna compounds comprising terminal substitutions
CA2781649C (fr) 2009-11-30 2017-07-11 Pluristem Ltd. Cellules adherentes du placenta et leur utilisation dans le traitement de pathologies
US9096843B2 (en) 2009-12-01 2015-08-04 Novo Nordisk A/S Peptidyl α-hydroxyglycine α-amidating lyases
WO2011068893A1 (fr) 2009-12-02 2011-06-09 Amgen Inc. Protéines de liaison qui se lient au fgfr1c humain, au β-klotho humain et à la fois au fgfr1c humain et au β-klotho humain
WO2011068569A1 (fr) 2009-12-04 2011-06-09 Biotium, Inc. Colorants xanthène substitués par hétérocycles
US20110136190A1 (en) 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
US9562235B2 (en) 2009-12-06 2017-02-07 A.B. Seeds Ltd. MicroRNA compositions and methods for enhancing plant resistance to abiotic stress
CA2783533A1 (fr) 2009-12-07 2011-06-16 Mascoma Corporation Expression heterologue de l'urease dans des hotes thermophiles anaerobies
EP2509997B1 (fr) 2009-12-07 2017-08-30 i2 Pharmaceuticals, Inc. Conjugués comprenant un échafaudage de substituts d'anticorps présentant des propriétés pharmacocinétiques améliorées
EP2510126B1 (fr) 2009-12-07 2017-08-09 Illumina, Inc. Indexage multi-échantillon pour un génotypage multiplexe
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US9121054B2 (en) * 2009-12-08 2015-09-01 Biohelix Corporation Detection of nucleic acid amplification products in the presence of an internal control sequence on an immunochromatographic strip
WO2011072091A1 (fr) 2009-12-09 2011-06-16 Quark Pharmaceuticals, Inc. Méthodes et compositions utilisées pour le traitement de maladies, d'affections ou de lésions du snc
DK3190183T3 (da) 2009-12-09 2019-10-14 Danisco Us Inc Sammensætninger og fremgangsmåder omfattende proteasevarianter
CA2836117C (fr) 2009-12-10 2017-08-15 Ottawa Hospital Research Institute Rhabdovirus oncolitique
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9173895B2 (en) 2009-12-16 2015-11-03 Curna, Inc. Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1
US20110154525A1 (en) 2009-12-17 2011-06-23 Pioneer Hi-Bred International, Inc. Maize event DP-040416-8 and methods for detection thereof
WO2011084632A1 (fr) 2009-12-17 2011-07-14 Pioneer Hi-Bred International, Inc. Evénement de maïs dp-032316-8 et ses procédés de détection
PL2512226T3 (pl) 2009-12-17 2019-10-31 Pioneer Hi Bred Int Modyfikacja DP-004114-3 kukurydzy i sposoby jej wykrywania
WO2011075595A1 (fr) 2009-12-17 2011-06-23 Pioneer Hi-Bred International, Inc. Maïs dp-043a47-3 et procédés de détection associés
US8431346B2 (en) * 2009-12-18 2013-04-30 Agrigenomics, Inc. Screening for arthrogryposis multiplex in bovines
US20120288861A1 (en) 2009-12-21 2012-11-15 Heinz-Josef Lenz Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
WO2011078441A1 (fr) 2009-12-21 2011-06-30 Seegene, Inc. Détection de cible par amorce tsg
US20110151457A1 (en) 2009-12-22 2011-06-23 Elitech Holding B.V. Hypertheromostable endonuclease iv substrate probe
WO2011076897A1 (fr) 2009-12-22 2011-06-30 Novozymes A/S Utilisation de variants d'amylase à basse température
CA2785020C (fr) 2009-12-22 2020-08-25 Sequenom, Inc. Procedes et kits pour identifier une aneuploidie
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
TW201125583A (en) * 2009-12-23 2011-08-01 Bioalliance Cv Anti-EpCAM antibodies that induce apoptosis of cancer cells and methods using same
CA2782375C (fr) 2009-12-23 2023-10-31 Opko Curna, Llc Traitement de maladies associees a la proteine ucp2 (uncoupling protein) par inhibition du produit de transcription antisens naturel en ucp2
DK2515899T3 (en) 2009-12-23 2016-08-15 Arca Biopharma Inc METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS
KR101891352B1 (ko) 2009-12-23 2018-08-24 큐알엔에이, 인크. 간세포 성장 인자(hgf)에 대한 천연 안티센스 전사체의 억제에 의한 hgf 관련 질환의 치료
WO2011079176A2 (fr) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes
BR112012015693A8 (pt) 2009-12-23 2018-06-26 Hills Pet Nutrition Inc métodos para diagnosticar uma doença renal em um canino, para tratar melhorar ou atrasar a progressão de uma doença renal, sonda de ácido nucléico, e, uso de uma sonda
AR081095A1 (es) 2009-12-28 2012-06-13 Evogene Ltd Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para aumentar el rendimiento de la planta, biomasa, tasa de crecimiento, vigor, contenido de aceite, tolerancia al estres abiotico y eficacia en el uso de nitrogeno
AU2010343143A1 (en) 2009-12-28 2012-06-28 Pioneer Hi-Bred International, Inc. Sorghum fertility restorer genotypes and methods of marker-assisted selection
CN102741401A (zh) 2009-12-29 2012-10-17 布特马斯先进生物燃料有限责任公司 己糖激酶在重组宿主细胞中的表达
EP2519239B1 (fr) 2009-12-29 2017-03-08 Gamida Cell Ltd. Méthodes d'amplification de la prolifération et de l'activité des cellules tueuses naturelles
RU2611186C2 (ru) 2009-12-29 2017-02-21 Курна, Инк. ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
ES2657452T3 (es) 2009-12-29 2018-03-05 Curna, Inc. Tratamiento de enfermedades relacionadas con el factor respiratorio nuclear 1 (NRF1) mediante inhibición de transcrito antisentido natural a NRF1
US9328335B2 (en) 2009-12-30 2016-05-03 Board Of Trustees Of Michigan State University Method to produce acetyldiacylglycerols (ac-TAGs) by expression of an acetyltransferase gene isolated from Euonymus alatus (burning bush)
CN102791862B (zh) 2009-12-31 2017-04-05 库尔纳公司 通过抑制胰岛素受体底物2(irs2)和转录因子e3(tfe3)的天然反义转录物而治疗irs2相关疾病
US20110165568A1 (en) 2009-12-31 2011-07-07 Life Technologies Corporation Sequences of e.coli 055:h7 genome
EP2521771A1 (fr) 2010-01-04 2012-11-14 Novozymes A/S Stabilisation des alpha-amylases en présence d'une déplétion en calcium et d'un ph acide
JP5886757B2 (ja) 2010-01-04 2016-03-16 カッパーアールエヌエー,インコーポレイテッド インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療
KR101754437B1 (ko) 2010-01-05 2017-07-05 바스큘라 바이오제닉스 리미티드 특이적 항-혈관형성 아데노바이러스제의 사용방법
CN102822342B (zh) 2010-01-06 2017-05-10 库尔纳公司 通过抑制胰腺发育基因的天然反义转录物而治疗胰腺发育基因相关疾病
WO2011084193A1 (fr) 2010-01-07 2011-07-14 Quark Pharmaceuticals, Inc. Composés oligonucléotidique comportant des extrémités sortantes non nucléotidiques
US8735327B2 (en) 2010-01-07 2014-05-27 Jeansee, Llc Combinatorial DNA taggants and methods of preparation and use thereof
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
CA2786535C (fr) 2010-01-11 2019-03-26 Curna, Inc. Traitement des maladies associees a la globuline se liant aux hormones sexuelles (shbg) par inhibition du produit de transcription anti-sens naturel en shbg
WO2011085334A1 (fr) 2010-01-11 2011-07-14 University Of Southern California Polymorphismes du cd44 prédisant le résultat clinique chez des patients atteints d'un cancer gastrique
EP2523681A1 (fr) 2010-01-12 2012-11-21 Vascular Biogenics Ltd. Procédés de production de vecteurs adénoviraux et préparations virales générées par ce biais
BR112012017152A2 (pt) 2010-01-12 2020-10-06 Ahram Biosystems, Inc. aparelho de convecção térmica de dois estágios e usos do mesmo.
CN102791847B (zh) 2010-01-12 2015-01-21 阿赫姆生物系统公司 三阶段热对流装置及其用途
US20110173569A1 (en) 2010-01-13 2011-07-14 Rockmelt, Inc. Preview Functionality for Increased Browsing Speed
WO2011088163A1 (fr) 2010-01-14 2011-07-21 President And Fellows Of Harvard College Procédés de modulation de remodélisation et structuration squelettiques par modulation de l'activité de shn2, de l'activité de shn3 ou de l'activité combinée de shn2 et de shn3
US9150889B2 (en) 2010-01-15 2015-10-06 The Regents Of The University Of California Electro-autotrophic synthesis of higher alcohols
US20110177512A1 (en) * 2010-01-19 2011-07-21 Predictive Biosciences, Inc. Method for assuring amplification of an abnormal nucleic acid in a sample
WO2011088588A1 (fr) 2010-01-20 2011-07-28 Honeywell International, Inc. Réacteur utilisable en vue d'une analyse quantitative d'acides nucléiques
ES2477498T3 (es) 2010-01-20 2014-07-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Proteína 4 del tipo angiopoyetina (ANGPTL4) para el mantenimiento de la integridad de la barrera celular del endotelio vascular
AU2011208625C1 (en) 2010-01-22 2022-08-18 Novo Nordisk Health Care Ag Growth hormones with prolonged in-vivo efficacy
CN102791730A (zh) 2010-01-22 2012-11-21 诺沃—诺迪斯克有限公司 低度o-糖基化的fgf21的制备方法
JP2013520162A (ja) 2010-01-22 2013-06-06 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 代謝障害の同定、査定、予防および治療のための組成物、キットおよび方法
AU2011208620B2 (en) 2010-01-22 2015-04-16 Novo Nordisk Health Care Ag Stable growth hormone compounds
JP2011147411A (ja) * 2010-01-25 2011-08-04 Seiko Epson Corp 核酸増幅方法および核酸増幅装置、ならびに核酸増幅用チップ
WO2011091393A1 (fr) 2010-01-25 2011-07-28 Rd Biosciences, Inc. Amplification par autorepliement d'acide nucléique cible
NO2529015T3 (fr) 2010-01-25 2018-04-14
CA2787311C (fr) 2010-01-27 2017-08-15 Yeda Research And Development Co. Ltd. Anticorps inhibant les metalloproteines
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
US8815896B2 (en) 2010-02-01 2014-08-26 The Institute Of Cancer Research: Royal Cancer Hospital 1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US8574832B2 (en) * 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
JP6134142B2 (ja) 2010-02-04 2017-05-24 ギリアド バイオロジクス, インク.Gilead Biologics, Inc. リシルオキシダーゼ様2(loxl2)に結合する抗体及びその使用方法
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
EP2353716A1 (fr) * 2010-02-05 2011-08-10 Ludwig-Maximilians-Universität München Procédé et appareil pour amplifier les séquences d'acide nucléique
US9896673B2 (en) 2010-02-10 2018-02-20 Novozymes A/S Compositions of high stability alpha amylase variants
EP2357220A1 (fr) 2010-02-10 2011-08-17 The Procter & Gamble Company Compositions de nettoyage comprenant des variantes de l'amylase de grande stabilité en présence d'un agent chélateur
US20110202284A1 (en) * 2010-02-10 2011-08-18 Mcreynolds Cristopher Novel groups of biomarkers for diagnosing alzheimer's disease
JP2013519869A (ja) 2010-02-10 2013-05-30 ノバルティス アーゲー 筋肉成長のための方法および化合物
US9410131B2 (en) 2010-02-11 2016-08-09 Yeda Research And Development Co. Ltd. Enzymatic systems for carbon fixation and methods of generating same
RU2012132908A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения производных химических соединений
CA2785529C (fr) * 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions et procedes de detection de petits arn
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US20130078614A1 (en) 2010-02-12 2013-03-28 Yonsei University Wonju Industry-Academic Cooperation Foundation Probe for hpv genotype diagnosis and analysis method thereof
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
WO2011100508A2 (fr) 2010-02-12 2011-08-18 Arizona Board Of Regents For And On Behalf Of Arizona State University Procédés et compositions liés à des fusions glycoprotéine-immunoglobuline
WO2011099015A1 (fr) 2010-02-15 2011-08-18 Yeda Research And Development Co. Ltd. Complexes multienzymatiques biologiquement modifiés comprenant des xylanases et utilisations associées
CN102782119B (zh) 2010-02-17 2016-03-16 布特马斯先进生物燃料有限责任公司 改善需Fe-S簇蛋白质的活性
EP2536849B1 (fr) 2010-02-17 2016-05-11 Gen-Probe Incorporated Compositions et procédés pour detecter l'acide nucléique d'atopobium vaginae
US9499860B2 (en) 2010-02-19 2016-11-22 The Ohio State University Primers and methods for nucleic acid amplification
US10030045B2 (en) 2010-02-19 2018-07-24 Ohio State Innovation Foundation Primers and methods for nucleic acid amplification
US8962586B2 (en) 2010-02-22 2015-02-24 Curna, Inc. Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
WO2011101744A2 (fr) 2010-02-22 2011-08-25 Population Genetics Technologies Ltd. Procédés d'extraction et de normalisation de régions à étudier
CA2791058A1 (fr) 2010-02-24 2011-09-01 Ben Gurion University Of The Negev Research And Development Authority Methodes d'inhibition de la necrose
US8298535B2 (en) 2010-02-24 2012-10-30 Rinat Neuroscience Corp. Anti-IL-7 receptor antibodies
EP2538943B1 (fr) 2010-02-25 2016-03-30 Dana-Farber Cancer Institute, Inc. Mutations de braf conférant une résistance aux inhibiteurs de braf
WO2011106696A2 (fr) 2010-02-26 2011-09-01 The Regents Of The University Of California Compositions et procédés pour la production de l-homoalanine
WO2011107939A1 (fr) 2010-03-01 2011-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthodes de prédiction de l'efficacité d'un traitement par anti-vegfa pour des tumeurs solides
WO2011107887A2 (fr) 2010-03-02 2011-09-09 Population Genetic Technologies Ltd. Procédés pour la réplication de polynucléotides à structure secondaire
WO2011109572A2 (fr) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Marqueurs biologiques prédictifs d'une réponse anticancéreuse aux inhibiteurs de kinase du récepteur du facteur de croissance insulinique 1
WO2011107994A1 (fr) 2010-03-04 2011-09-09 Yeda Research And Development Co. Ltd. Procédés de mesure de la stabilité d'une protéine
WO2011108930A1 (fr) 2010-03-04 2011-09-09 Interna Technologies Bv Molécule de miarn définie par sa source et ses utilisations thérapeutiques et en diagnostic pour maladies ou états associés à l'emt
FR2957090A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel irritant d'un compose test
FR2957089A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant d'un compose test
FR2957088A1 (fr) 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant et/ou irritant d'un compose test
JP6148013B2 (ja) 2010-03-05 2017-06-14 リグショスピタレト 補体活性化のキメラ抑制分子
EP2542676A1 (fr) 2010-03-05 2013-01-09 Synthetic Genomics, Inc. Procédés de clonage et de manipulation de génomes
WO2011112534A1 (fr) 2010-03-08 2011-09-15 Dana-Farber Cancer Institute, Inc. Enrichissement d'une pcr froide complète doté d'une séquence de blocage de référence
NZ601784A (en) 2010-03-08 2014-08-29 Monsanto Technology Llc Polynucleotide molecules for gene regulation in plants
WO2011111034A1 (fr) 2010-03-08 2011-09-15 Yeda Research And Development Co. Ltd. Production de protéines recombinantes dans des systèmes hétérologues
EA030276B1 (ru) 2010-03-09 2018-07-31 Дана-Фарбер Кэнсер Инститьют, Инк. Способы идентификации страдающих раком пациентов и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака
CN102918159A (zh) 2010-03-11 2013-02-06 雅各布·埃德尔 产生氢的方法
SG183867A1 (en) 2010-03-11 2012-10-30 Rinat Neuroscience Corp ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
EP2369325A1 (fr) 2010-03-12 2011-09-28 Eppendorf Ag Analyse de réseau pour détection en ligne
MX2012010399A (es) 2010-03-12 2012-10-05 Dupont Nutrition Biosci Aps Proceso.
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
CA2793424A1 (fr) 2010-03-18 2011-09-22 Cornell University Preparation d'anticorps correctement plies utilisant la presentation sur la membrane interieure d'intermediaires de translocation twin-arginine
WO2011114251A1 (fr) 2010-03-18 2011-09-22 Danisco A/S Produits alimentaires
CN102939378A (zh) 2010-03-25 2013-02-20 通用电气公司 用于快速检测嗜肺军团菌的组合物和方法
US8916345B2 (en) * 2010-03-26 2014-12-23 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
EP2553463B1 (fr) 2010-03-26 2017-05-03 Hongzhi Zou Procédés et substances pour la détection de tumeurs colorectales
CA2794483C (fr) 2010-03-26 2020-07-07 Trustees Of Dartmouth College Vista, une proteine mediatrice regulatrice des lymphocytes t, agents de liaison a vista et utilisation associee
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
DK2552961T3 (en) 2010-03-30 2018-03-05 Janssen Biotech Inc HUMANIZED IL-25 ANTIBODIES
US8951940B2 (en) 2010-04-01 2015-02-10 Illumina, Inc. Solid-phase clonal amplification and related methods
AU2011235538B2 (en) 2010-04-01 2014-04-03 Elanco Tiergesundheit Ag Macrocyclic lactone resistance marker for Dirofilaria immitis
WO2011123745A2 (fr) 2010-04-02 2011-10-06 Opko Curna Llc Traitement de maladies liées au facteur de stimulation des colonies 3 (csf3) par inhibition du produit de la transcription antisens naturel en csf3
EP2556171B1 (fr) 2010-04-05 2015-09-02 Prognosys Biosciences, Inc. Tests biologiques à codage spatial
WO2011125015A2 (fr) 2010-04-05 2011-10-13 Bar-Ilan University Polypeptides formant des pores pouvant être activés par une protéase
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
JP2013523154A (ja) 2010-04-06 2013-06-17 マサチューセッツ・インスティトュート・オブ・テクノロジー 転写物測定値数が減少した、遺伝子発現プロファイリング
US9125931B2 (en) 2010-04-06 2015-09-08 Massachusetts Institute Of Technology Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers
CN102858979B (zh) 2010-04-09 2018-01-26 库尔纳公司 通过抑制成纤维细胞生长因子21(fgf21)的天然反义转录物而治疗fgf21相关疾病
WO2011128897A1 (fr) 2010-04-12 2011-10-20 Technion Research & Development Foundation Ltd. Population de cellules progénitrices pancréatiques et leurs méthodes d'isolement et d'utilisation
EP2557913B1 (fr) 2010-04-12 2016-08-03 Ben Gurion University Of The Negev Research And Development Authority Sulfotransférase d'une microalgue rouge et utilisations de celle-ci
MX360403B (es) 2010-04-15 2018-10-31 Abbvie Inc Proteinas de union a amiloide beta.
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
PL2558573T3 (pl) 2010-04-15 2017-08-31 Danisco Us Inc. Kompozycje i sposoby obejmujące warianty proteazy
EP2558577B1 (fr) 2010-04-16 2018-12-12 Nuevolution A/S Complexes bifonctionnels et procédés de fabrication et d'utilisation de tels complexes
MY161567A (en) 2010-04-16 2017-04-28 Zeus Scientific Inc Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
CN103079567A (zh) 2010-04-17 2013-05-01 拜尔健康护理有限责任公司 用于疾病和病症的治疗和预防的氟取代的ω-羧基芳基二苯脲的合成代谢产物
JP5858984B2 (ja) 2010-04-18 2016-02-10 イェダ リサーチ アンド デベロップメント カンパニー リミテッド ErbB/ErbBリガンドに関連する疾患を治療するための分子及びその分子を使用する方法
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2011133512A1 (fr) 2010-04-19 2011-10-27 Research Development Foundation Variants de rtef-1 et utilisations de ceux-ci
BR112012026945B1 (pt) 2010-04-20 2021-05-25 Qiagen Gmbh método e aparelho para controlar a temperatura de um líquido
US9206484B2 (en) 2010-04-21 2015-12-08 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
CN102918152B (zh) 2010-04-23 2016-04-13 佛罗里达大学研究基金公司 用于治疗莱伯氏先天性黑蒙-1(lca1)的raav-鸟苷酸环化酶组合物及方法
WO2011139714A2 (fr) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps se rapportant à des fragments protéiques de la cystéinyl-arnt synthétase
EP2564200B8 (fr) 2010-04-27 2019-10-02 The Regents of The University of California Biomarqueurs de cancer et leurs procédés d'utilisation
US8961960B2 (en) 2010-04-27 2015-02-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
WO2011137192A1 (fr) 2010-04-27 2011-11-03 The Regents Of The University Of California Production de 1,4-butanediol par des microorganismes recombinés
CA2797200C (fr) 2010-04-28 2020-03-31 Evogene Ltd. Polynucleotides et polypeptides isoles et procedes d'utilisation de ceux-ci pour l'augmentation du rendement vegetal et/ou des caracteristiques agricoles
EP2383572A1 (fr) 2010-04-28 2011-11-02 Assistance Publique Hôpitaux de Marseille Test de l'activité humorale cellulaire (CHAT)
JP5454338B2 (ja) 2010-04-28 2014-03-26 株式会社島津製作所 液滴操作によるリアルタイム核酸増幅法
EP2563911B1 (fr) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Compositions thérapeutiques, diagnostiques et d'anticorps à base de fragments de protéines d'aminoacyl-arnt synthétases
CN103118693B (zh) 2010-04-29 2017-05-03 Atyr 医药公司 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011137369A1 (fr) 2010-04-29 2011-11-03 The Regents Of The University Of California Production d'acide gamma-aminobutyrique par des microorganismes recombinés
WO2011139854A2 (fr) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à based'anticorps associées à des fragments protéiques d'asparaginyl-arnt-synthétases
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US8981045B2 (en) 2010-05-03 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
CA2797977C (fr) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, diagnostiques et a base d'anticorps liees a des fragments proteiques de phenylalanyl-alpha-arnt-synthetases
CN102933711B (zh) 2010-05-03 2018-01-02 库尔纳公司 通过抑制沉默调节蛋白(sirt)的天然反义转录物而治疗沉默调节蛋白(sirt)相关疾病
WO2011139986A2 (fr) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à des fragments protéiques d'arginyle-arnt synthétases
US20130053277A1 (en) 2010-05-04 2013-02-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of identifying inhibitors of polypeptides-of-interest
WO2011140267A2 (fr) 2010-05-04 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées à des fragments protéiques de complexe multi-arnt synthétase p38
EP2566500B1 (fr) 2010-05-05 2017-04-12 Rappaport Family Institute for Research in the Medical Sciences Ccl1 pour son utilisation thérapeutique
IL208820A0 (en) 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives
ES2625751T3 (es) 2010-05-06 2017-07-20 The Procter & Gamble Company Productos de consumo con variantes de proteasa
ES2593614T3 (es) 2010-05-06 2016-12-12 Adaptive Biotechnologies Corporation Monitorización de estados de salud y enfermedad usando perfiles de clonotipos
US20120135912A1 (en) 2010-05-10 2012-05-31 Perseid Therapeutics Llc Polypeptide inhibitors of vla4
AU2011250904A1 (en) 2010-05-11 2012-11-08 Dow Agrosciences Llc spnK strains
US10077232B2 (en) 2010-05-12 2018-09-18 Arbutus Biopharma Corporation Cyclic cationic lipids and methods of use
WO2011141705A1 (fr) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc. Nouveaux lipides cationiques et procédés d'utilisation de ceux-ci
PL2569417T3 (pl) 2010-05-13 2018-12-31 Tel Hashomer Medical Research Infrastructure And Services Ltd. Izolowane populacje dorosłych komórek nerkowych i sposoby ich izolowania i stosowania
WO2011142970A2 (fr) 2010-05-14 2011-11-17 University Of Iowa Research Foundation Aptamères d'acide nucléique her2
WO2011143579A2 (fr) 2010-05-14 2011-11-17 Arizona Board Of Regents On Behalf Of University Of Arizona Méthodes de prévention et de traitement du cancer fondées sur la teneur en polyamines provenant de l'alimentation
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
TWI531370B (zh) 2010-05-14 2016-05-01 可娜公司 藉由抑制par4天然反股轉錄本治療par4相關疾病
US9309565B2 (en) 2010-05-14 2016-04-12 Life Technologies Corporation Karyotyping assay
TW201144442A (en) 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
WO2011146725A1 (fr) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarqueurs pour un inhibiteur à multiples kinases
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 HIF-2α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 HIF?2α 형질전환 마우스 및 이의 용도
US8618253B2 (en) 2010-05-25 2013-12-31 Samsung Techwin Co., Ltd. Modified RNAse H and detection of nucleic acid amplification
GB201008727D0 (en) 2010-05-25 2010-07-07 Glaxo Group Ltd Biomarkers
WO2011149032A1 (fr) 2010-05-26 2011-12-01 東ソー株式会社 Dispositif de fixation d'échantillon biologique
US8895528B2 (en) 2010-05-26 2014-11-25 Curna, Inc. Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
US8980858B2 (en) 2010-05-26 2015-03-17 Curna, Inc. Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
SG185781A1 (en) 2010-05-28 2013-01-30 Solazyme Inc Food compositions comprising tailored oils
EP2576577B1 (fr) 2010-05-28 2015-03-18 Life Technologies Corporation Synthèse de 2',3'-didésoxynucléoside pour synthèse d'adn automatique et polymérisation activée par pyrophospholyse
CN103118694B (zh) 2010-06-01 2016-08-03 Atyr医药公司 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
WO2011153276A2 (fr) 2010-06-01 2011-12-08 California Institute Of Technology Enzymes cellobiohydrolases chimères fonctionnelles et stables de classe i
US8435737B2 (en) 2010-06-02 2013-05-07 Cal Poly Corporation Primers for the rapid and specific detection of propane-oxidizing and butane-oxidizing microorganisms and methods of using same
CN103153311A (zh) 2010-06-03 2013-06-12 药品循环公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
WO2011151833A1 (fr) 2010-06-03 2011-12-08 Ramot At Tel-Aviv University Ltd. Méthodes de traitement du diabète et compositions capables de traiter le diabète
US9422598B2 (en) 2010-06-04 2016-08-23 Biomerieux Method and kit for the prognosis of colorectal cancer
WO2011154943A1 (fr) 2010-06-07 2011-12-15 Yeda Research And Development Co. Ltd. Cellulases modifiées à thermostabilité améliorée
EP2576824A2 (fr) 2010-06-07 2013-04-10 Roche Diagnostics GmbH Marqueurs d'expression génique pour la prédiction d'une réponse à un traitement par un médicament anticorps monoclonal inhibant le récepteur de l'interleukine-6
JP2013529092A (ja) 2010-06-07 2013-07-18 − ファビアン、オスナット アシュル 低酸素症に関連する状態を診断する方法およびキット
WO2011156356A1 (fr) 2010-06-09 2011-12-15 Zymogenetics, Inc. Protéines de fusion vstm3 dimères et compositions et procédés connexes
ES2873933T3 (es) 2010-06-09 2021-11-04 Dana Farber Cancer Inst Inc Una mutación de MEK1 que confiere resistencia a inhibidores de RAF y de MEK
EP3290529B1 (fr) 2010-06-11 2019-05-22 Life Technologies Corporation Nucléotides alternatifs circule dans des procédés de séquençage par synthèse
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US8691574B2 (en) 2010-06-15 2014-04-08 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
US9187787B2 (en) 2010-06-16 2015-11-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of diagnosing and treating cancer
WO2011158242A2 (fr) 2010-06-16 2011-12-22 Futuragene Israel Ltd. Plantes résistantes aux organismes nuisibles
US8933282B2 (en) 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
CN103201376A (zh) 2010-06-17 2013-07-10 布特马斯先进生物燃料有限责任公司 用于生产丁醇的酵母生产培养物
BR112012032176A2 (pt) 2010-06-17 2015-09-08 Dupont Nutrition Biosci Aps processo de tratamento de sementes que contém óleo, método de obtenção de óleo de sementes vegetais, processo de produção de um óleo vegetal refinado e óleo vegetal bruto ou refinado que pode ser obtido por meio de um método ou processo
CA2801997C (fr) 2010-06-18 2016-05-31 F. Hoffmann-La Roche Ag Adn polymerases presentant une discrimination accrue des mesappariements a l'extremite 3'
EP2582806B1 (fr) 2010-06-18 2015-12-16 Roche Diagnostics GmbH Adn polymérases présentant une discrimination accrue des mésappariements à l'extrémité 3'
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
US8735120B2 (en) 2010-06-18 2014-05-27 Roche Molecular Systems, Inc. DNA polymerases with increased 3′-mismatch discrimination
EP2582808B1 (fr) 2010-06-18 2015-04-22 Roche Diagniostics GmbH Polymerases adn avec une distinction ameliorées des mésappariements 3' de paires de bases
JP5876478B2 (ja) 2010-06-18 2016-03-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 増大した3’末端ミスマッチ識別能を有するdnaポリメラーゼ
EP2582805B1 (fr) 2010-06-18 2015-02-25 Roche Diagnostics GmbH Polymérases adn avec une distinction ameliorées des mésappariements 3' de paires de bases
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
WO2011157436A1 (fr) 2010-06-18 2011-12-22 Roche Diagnostics Gmbh Adn polymérases présentant une discrimination accrue des mésappariements à l'extrémité 3'
US8715991B2 (en) 2010-06-18 2014-05-06 Roche Molecular Systems, Inc. DNA polymerases with increased 3'-mismatch discrimination
EP2582850B1 (fr) 2010-06-21 2016-11-09 Life Technologies Corporation Compositions, trousses et procédés pour la synthèse et/ou la détection d'acides nucléiques
IT1405994B1 (it) 2010-06-22 2014-02-06 Euroclone Spa Metodo ad elevata sensibilita' per rilevare un acido nucleico target in un campione
EP2423688B1 (fr) 2010-06-22 2016-03-23 F. Hoffmann-La Roche AG Conteneur de suspension pour des particules de liaison pour l'isolation de matériel biologique
CA2803391C (fr) 2010-06-22 2021-11-09 Neogenix Oncology, Inc. Anticorps npc1 qui lient un epitope muc5ac
US9771579B2 (en) 2010-06-23 2017-09-26 Curna, Inc. Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA
CA2801928C (fr) 2010-06-24 2018-04-10 Quark Pharmaceuticals, Inc. Composes a base d'arn double brin pour le gene rhoa et leur utilisation
US9096952B2 (en) 2010-06-24 2015-08-04 Population Genetics Technologies Ltd. Methods and compositions for polynucleotide library production, immortalization and region of interest extraction
WO2011162612A1 (fr) 2010-06-25 2011-12-29 Wageningen Universiteit Procédé permettant de moduler le niveau de phosphorylation de l'amidon dans une lignée végétale, procédé permettant de sélectionner une plante ou une partie de celle-ci, incluant une graine et un tubercule, et son utilisation
EP2585587B1 (fr) 2010-06-28 2017-08-09 Codexis, Inc. Acyle réductases formant des alcools gras (far) et procédés pour les utiliser
US8623623B2 (en) 2010-06-29 2014-01-07 E I Du Pont De Nemours And Company Xylose utilization in recombinant Zymomonas
US8679822B2 (en) 2010-06-29 2014-03-25 E I Du Pont De Nemours And Company Xylose utilization in recombinant zymomonas
CA2802741C (fr) 2010-06-30 2020-07-07 Gen-Probe Incorporated Procede et appareillage pour identifier des echantillons contenant un analyte par utilisation d'une determination de l'analyte par une lecture unique, et de signaux de pilotage du procede
WO2012003474A2 (fr) 2010-07-02 2012-01-05 The University Of Chicago Compositions et méthodes associées à des variants de protéine a (spa)
EP2591106A1 (fr) 2010-07-06 2013-05-15 InteRNA Technologies B.V. Miarn et ses utilisations diagnostiques et thérapeutiques pour des maladies ou des états associés au mélanome, ou pour des maladies ou des états associés à la voie braf activée
CN103109187B (zh) 2010-07-07 2015-03-25 密执安大学评议会 乳腺癌的诊断和治疗
JP5897002B2 (ja) 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル, インコーポレイテッド プログラミングによる内皮細胞の産生
GB201011513D0 (en) 2010-07-08 2010-08-25 Danisco Method
TW201217526A (en) 2010-07-09 2012-05-01 Biogen Idec Hemophilia Inc Chimeric clotting factors
WO2012009373A2 (fr) 2010-07-12 2012-01-19 Gen-Probe Incorporated Compositions et dosages pour détecter le virus h1n1 de la grippe a porcine, le virus h1 de la grippe a saisonnière et les acides nucléiques du virus h3 de la grippe a saisonnière
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ, インコーポレイテッド グリシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2012007945A2 (fr) 2010-07-12 2012-01-19 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Polynucléotides isolés et procédés et plantes les utilisant pour la régulation de l'acidité des plantes
EP2593547B1 (fr) 2010-07-14 2017-11-15 CuRNA, Inc. Traitement de maladies liées à « discs large homolog » (dlg) par inhibition de transcrit antisens naturel de dlg
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
US20130189284A1 (en) 2010-07-15 2013-07-25 Technion Research & Development Foundation Ltd. Antibodies with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides
WO2012007951A1 (fr) 2010-07-15 2012-01-19 Technion Research & Development Foundation Ltd. Entités isolées à affinité élevée dotées d'une spécificité telle que celle des récepteurs de lymphocytes t pour des complexes natifs du cmh de classe ii et peptides auto-antigènes de la décarboxylase de l'acide glutamique (gad)
US10106812B2 (en) 2010-07-15 2018-10-23 Technion Research & Development Foundation Limited Nucleic acid construct for increasing abiotic stress tolerance in plants
US10106576B2 (en) 2010-07-16 2018-10-23 Bioatla, Llc Methods of protein evolution
WO2012008839A2 (fr) 2010-07-16 2012-01-19 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Procédé d'analyse d'un échantillon de sang d'un sujet dans le but de détecter la présence d'un marqueur d'une maladie
WO2012010516A1 (fr) 2010-07-22 2012-01-26 Novo Nordisk Health Care Ag Conjugués d'hormone de croissance
AU2011280958B2 (en) 2010-07-22 2014-10-09 Massachusetts Institute Of Technology Multiple input biologic classifier circuits for cells
WO2012011113A2 (fr) 2010-07-22 2012-01-26 Shai Yarkoni Cellules immunitaires régulatrices possédant un effet de destruction cellulaire ciblé accru
WO2012012709A2 (fr) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Méthodes de détection de maladies ou de pathologies cardiovasculaires
KR20130041962A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 식작용 세포를 사용하여 질환 또는 상태를 검출하는 방법
CA2806296A1 (fr) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Procedes de detection de maladies ou d'etats associes au rein
US20130203624A1 (en) 2010-07-23 2013-08-08 President And Fellows Of Harvard College Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions
EP2752245A3 (fr) 2010-07-23 2016-08-24 Beckman Coulter, Inc. Système ou procédé comprenant des unités analytiques
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
CA2806291C (fr) 2010-07-23 2023-08-29 President And Fellows Of Harvard College Procedes de detection de signatures de maladies ou pathologies dans des liquides biologiques
CA2806734A1 (fr) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions de stabilisation d'adn, d'arn, de proteines salivaires et d'autres echantillons biologiques lors du transport et du stockage a temperatures ambiantes
EP2598660B1 (fr) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions de stabilisation d'adn, d'arn, de protéines dans le sang et d'autres échantillons biologiques lors du transport et du stockage à températures ambiantes
US20130130311A1 (en) 2010-07-27 2013-05-23 Yeda Research And Development Co., Ltd. Methods and systems for assessing clonality of cell cultures
WO2012014205A1 (fr) 2010-07-27 2012-02-02 Technion Research & Development Foundation Ltd. Cellules progénitrices mésenchymateuses isolées et matrice extra-cellulaire produite au moyen de celles-ci
US20130130387A1 (en) 2010-07-27 2013-05-23 Technion Research & Development Foundation Limited Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
CA2802550C (fr) 2010-07-29 2019-01-15 F. Hoffmann-La Roche Ag Pcr generique
WO2012013733A1 (fr) 2010-07-29 2012-02-02 F. Hoffmann - La Roche Ag Préparation d'échantillons génériques
ES2606688T3 (es) 2010-07-29 2017-03-27 F. Hoffmann-La Roche Ag Ácidos nucleicos de control para parámetros múltiples
CN103069007A (zh) 2010-07-29 2013-04-24 霍夫曼-拉罗奇有限公司 微生物核酸的定性和定量检测
US9175354B2 (en) 2010-08-03 2015-11-03 Life Technologies Corporation Detection of Salmonella enterica subspecies enterica serovar Enteritidis in food and environmental samples, methods and compositions therefor
JP5936218B2 (ja) 2010-08-04 2016-06-22 セルラー ダイナミクス インターナショナル, インコーポレイテッド 不死化b細胞のリプログラミング
WO2012017439A2 (fr) 2010-08-04 2012-02-09 Ramot At Tel-Aviv University Ltd. Procédés de traitement de maladies auto-immunes du système nerveux central (snc) et de maladies neurodégénératives
WO2012016357A1 (fr) 2010-08-06 2012-02-09 Capitalbio Corporation Dosage à base de micropuces comprenant des particules, destiné à analyser des interactions moléculaires
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
JP5903718B2 (ja) 2010-08-09 2016-04-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Hiv−1感染の処置のための方法及び医薬的組成物
EP2418286A1 (fr) 2010-08-10 2012-02-15 QIAGEN GmbH Procédé amélioré pour l'amplification isotherme d'acides nucléiques
WO2012019235A1 (fr) 2010-08-11 2012-02-16 Murdoch Childrens Research Institute Traitement et diagnostic de troubles et d'affections épigénétiques
WO2012021845A2 (fr) 2010-08-12 2012-02-16 Fate Therapeutics, Inc. Traitement amélioré utilisant des cellules hématopoïétiques souches et progénitrices
AU2011289275A1 (en) 2010-08-12 2013-02-21 Theraclone Sciences, Inc. Anti-hemagglutinin antibody compositions and methods of use thereof
PT2603600T (pt) 2010-08-13 2019-02-27 Aileron Therapeutics Inc Macrociclos peptidomiméticos
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US20120058461A1 (en) 2010-08-18 2012-03-08 Abbott Laboratories Molecular detection of xmrv infection
CN111426533A (zh) 2010-08-18 2020-07-17 压力生物科技公司 流通式高静压的微流样本的预处理设备及其相关方法
CN106198656B (zh) 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
WO2012024518A1 (fr) 2010-08-18 2012-02-23 Abbott Laboratories Détection moléculaire d'une infection par le xmrv
EP3192880B1 (fr) 2010-08-18 2019-10-09 Fred Hutchinson Cancer Research Center Agents d'acides nucléiques pour le traitement de la dystrophie facioscapulohumérale (fshd)
WO2012022777A1 (fr) 2010-08-19 2012-02-23 Novozymes A/S Procédé de criblage d'une sporulation induite
WO2012025914A1 (fr) 2010-08-22 2012-03-01 Ramot At Tel-Aviv University Ltd. Cellules souches pluripotentes induites dérivées de cellules bêta pancréatiques humaines
WO2012025925A1 (fr) 2010-08-24 2012-03-01 Rappaport Family Institute For Research In The Medical Sciences Procédés d'amélioration de la transplantation en utilisant des sdf-1alpha
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
WO2012030856A2 (fr) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, procédés et mélanges réactionnels pour détection du virus xénotrope apparenté aux virus de la leucémie murine
BR112013004851A2 (pt) 2010-08-30 2016-06-07 Evogene Ltd método de aumento de eficiência do uso de nitrogênio, rendimento, biomassa, taxa de crescimento, vigor, conteúdo de óleo, rendimento da fibra e/ou tolerância ao estresse abiótico de uma planta, polinucleotídeo isolado, estrutura de ácido nucleio, polipeptídeo isolado, célula vegetal e planta transgêncica
JP5794770B2 (ja) 2010-08-31 2015-10-14 キリンホールディングス株式会社 グリコアルカロイド生合成酵素活性を有するタンパク質とそれをコードする遺伝子
EP3556396B1 (fr) 2010-08-31 2022-04-20 Theraclone Sciences, Inc. Anticorps de neutralisation du virus de l'immunodéficience humaine (vih)
DK2753352T4 (da) 2010-09-03 2022-09-12 Valneva Austria Gmbh Isoleret polypeptid af toxin a og toxin b proteinerne fra c. difficile og anvendelser deraf
EP3269806B1 (fr) 2010-09-07 2020-05-27 Butamax (TM) Advanced Biofuels LLC Intégration d'un polynucléotide codant pour un polypeptide qui catalyse la conversion en acétolactate de pyruvate
EP2613799A1 (fr) 2010-09-07 2013-07-17 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Translecture d'acétylcholinestérase (ache-r) pour le traitement ou la prévention de la maladie de parkinson
EP2426222A1 (fr) 2010-09-07 2012-03-07 F. Hoffmann-La Roche AG Tampon générique pour amplification
WO2012032519A2 (fr) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthodes de diagnostic de la maladie de parkinson
WO2012032510A1 (fr) 2010-09-07 2012-03-15 Yeda Research And Development Co. Ltd. Amorces pour l'amplification d'adn et procédés de sélection de ces dernières
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
SG10201509953VA (en) 2010-09-07 2016-01-28 Technion Res & Dev Foundation Novel Methods And Culture Media For Culturing Pluripotent Stem Cells
CA2810631A1 (fr) 2010-09-08 2012-03-15 Yeda Research And Development Co. Ltd. Combinaison de medicaments immunosuppresseurs pour une prise de greffe a long terme et stable
CA2810838C (fr) 2010-09-08 2021-07-06 The Board Of Regents Of The University Of Texas System Therapie anticancereuse sur la base des recepteurs de la somatostatine
JP5977238B2 (ja) 2010-09-08 2016-08-24 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 抗白血病/リンパ腫処置のための抗第三者セントラルメモリーt細胞の使用
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
CA2810520C (fr) 2010-09-10 2019-03-12 Bio-Rad Laboratories, Inc. Choix de la taille de l'adn pour l'analyse de la chromatine
WO2012035539A1 (fr) 2010-09-15 2012-03-22 Ramot At Tel-Aviv University Ltd. Procédés d'expansion et de redifférenciation de cellules bêta des îlots
WO2012037531A1 (fr) 2010-09-16 2012-03-22 Gen-Probe Incorporated Sondes de capture immobilisables par l'intermédiaire d'une queue nucléotidique l
US20130210901A1 (en) 2010-09-20 2013-08-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of treating neurodegenerative diseases
EP2937423A1 (fr) 2010-09-21 2015-10-28 Life Technologies Corporation Mutations se33 ayant un impact sur la concordance de génotype
ES2690753T3 (es) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
WO2012038049A2 (fr) 2010-09-22 2012-03-29 Roche Diagnostics Gmbh Amplification de cibles d'acide nucléique distantes au moyen d'amorces artificielles
WO2012038744A2 (fr) 2010-09-22 2012-03-29 Genome Research Limited Détection de mutations
ES2719624T3 (es) 2010-09-23 2019-07-11 Prec Biologics Inc Peptidomiméticos de cáncer de colon y de páncreas
WO2012040387A1 (fr) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Capture directe, amplification et séquençage d'adn cible à l'aide d'amorces immobilisées
WO2012040619A2 (fr) 2010-09-24 2012-03-29 Massachusetts Eye And Ear Infirmary Méthodes et compositions pour le pronostic et/ou la détection d'une dégénérescence maculaire liée à l'âge
US20120077738A1 (en) 2010-09-24 2012-03-29 Wisconsin Alumni Research Foundation Compositions and methods for predicting hcv susceptibility to antiviral agents
CA2808656C (fr) 2010-09-27 2019-12-03 Vipergen Procede de preparation d'une banque enrichie
WO2012042289A1 (fr) 2010-09-28 2012-04-05 Inserm ( Institut National De La Sante Et De La Recherche Medicale) Méthodes et compositions pharmaceutiques destinées au traitement de maladies associées à la densité osseuse
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
EP3447155A1 (fr) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Dosages en sandwich dans des gouttelettes
EP2622065B1 (fr) 2010-10-01 2016-09-07 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Manipulation de la fonction de cellules souches par des isoformes p53
EP3438289A1 (fr) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Compositions, procédés et kits de détection d'acides nucléiques de l'adénovirus
ES2640755T3 (es) 2010-10-06 2017-11-06 Curna, Inc. Tratamiento de enfermedades relacionadas con la Sialidasa 4 (neu4) mediante inhibición del transcrito antisentido natural al gen neu4
GB2512213B (en) 2010-10-08 2015-02-11 Harvard College High-throughput single cell barcoding
WO2012048340A2 (fr) 2010-10-08 2012-04-12 President And Fellows Of Harvard College Séquençage immunitaire à haut débit
US10479969B2 (en) 2010-10-11 2019-11-19 Phycoil Biotechnology International. Inc. Utilization of wastewater for microalgal cultivation
WO2012051301A1 (fr) 2010-10-12 2012-04-19 President And Fellows Of Harvard College Procédés pour identifier des modulateurs du métabolisme des triglycérides, pour moduler le métabolisme des triglycérides et pour identifier des sujets à risque pour le métabolisme anormal des triglycérides
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
WO2012049279A1 (fr) 2010-10-14 2012-04-19 Universitaet Des Saarlandes Moyens et procédés d'application d'extension d'amorce de nucléotide simple avec une chromatographie hplc de paire d'ions en phase inverse (sirph) pour le diagnostic de polymorphismes de nucléotides simples (snp)
CN108404115A (zh) 2010-10-15 2018-08-17 纽约市哥伦比亚大学理事会 肥胖症-相关的基因和它们的蛋白和其用途
CN103237880B (zh) 2010-10-15 2016-08-03 环球生物研究株式会社 利用多功能分注单元的核酸自动处理装置及其方法
WO2012049316A1 (fr) 2010-10-15 2012-04-19 Olink Ab Procédés à plage dynamique
EP3075396A1 (fr) 2010-10-17 2016-10-05 Yeda Research and Development Co. Ltd. Procédés et compositions utilisables en vue du traitement de pathologies médicales associées à l'insuline
WO2012052878A1 (fr) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Polynucléotides isolés et constructions d'acide nucléique pour diriger l'expression d'un gène d'intérêt dans des cellules
BR112013010952B1 (pt) 2010-10-22 2020-08-25 T2 Biosystems, Inc. métodos para detectar a presença de um analito de ácido nucleico e uma espécie de candida em uma amostra líquida, para detectar a presença de um patógeno, um vírus e um ácido nucleico alvo em uma amostra de sangue total, e para amplificação de um ácido nucleico de patógeno alvo em uma amostra de sangue total, bem como sistema para a detecção de um ou mais analitos e cartucho removível dimensionado para facilitar inserção e remoção de um sistema
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012052758A1 (fr) 2010-10-22 2012-04-26 Astrazeneca Ab Biomarqueurs de réponse pour des antagonistes de iap dans des cancers humains
RU2597972C2 (ru) 2010-10-22 2016-09-20 Курна Инк. Лечение заболеваний, связанных с геном альфа-l-идуронидазы (idua), путем ингибирования природного антисмыслового транскрипта гена idua
US9115408B2 (en) 2010-10-26 2015-08-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid Salmonella serotyping assay
WO2012058303A2 (fr) 2010-10-26 2012-05-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Dosage de sérotypage rapide de salmonella
JP5872569B2 (ja) 2010-10-27 2016-03-01 キャピタルバイオ コーポレーションCapitalBio Corporation マイクロアレイに基づくアッセイのための粒子と結合させた発光団で標識された分子
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
WO2012056452A2 (fr) 2010-10-27 2012-05-03 Nanocyte (Israel) Ltd. Compositions pharmaceutiques et dispositifs d'administration comprenant des cellules ou capsules urticantes
WO2012058073A2 (fr) 2010-10-27 2012-05-03 Harrisvaccines, Inc. Procédés et compositions pour protéger les invertébrés aquatiques contre les maladies
CN103370337B (zh) 2010-10-28 2015-12-09 耶达研究及发展有限公司 用于产生针对金属酶的抗体的方法
US10767214B2 (en) 2010-10-28 2020-09-08 Clinical Genomics Pty Ltd Method of microvesicle enrichment
US20130315934A1 (en) 2010-10-28 2013-11-28 Yale University Methods and Compositions for Assessing and Treating Cancer
US20130295571A1 (en) 2010-10-29 2013-11-07 Institut National De La Santee Et De La Recherche Medicale ( Inserm) Marker of breast tumors from the luminal-b subtype
EP3388532B1 (fr) 2010-11-01 2021-03-10 Gen-Probe Incorporated Capture intégrée et amplification d'acide nucléique cible de séquençage
CA2816311C (fr) 2010-11-01 2018-07-17 Becton, Dickinson And Company Essai de gardnerella vaginalis
CN103189516A (zh) 2010-11-02 2013-07-03 科德克希思公司 用于产生可发酵糖类的组合物和方法
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
EP2447721B1 (fr) 2010-11-02 2017-03-15 F. Hoffmann-La Roche AG Instrument et procédé pour thermosceller automatiquement une microplaque
SI2635299T1 (sl) 2010-11-02 2020-02-28 The Trustees Of Columbia University In The City Of New York Postopki za zdravljenje motenj izgube las
WO2012061382A1 (fr) 2010-11-02 2012-05-10 Codexis, Inc. Souches fongiques améliorées
CN103314101B (zh) 2010-11-03 2016-05-18 加利福尼亚大学董事会 通过蛋白质生物质发酵的重组微生物的生物燃料和化学生产
BR112013010825A2 (pt) 2010-11-03 2019-09-24 Futuragene Israel Ltda plantas transgênicas com rendimentos melhorados de sacarificação e métodos para geração das mesmas
EP2635105B1 (fr) 2010-11-04 2017-12-20 Ben-Gurion University of The Negev Research and Development Authority Acyl-coa: gène de type diacylglycérol acyltransférase 1 (ptdgat1) et utilisations de celui-ci
WO2012063011A2 (fr) 2010-11-08 2012-05-18 Bg Research Ltd Chauffage et refroidissement de cuves à réaction biologique à faible volume
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
EP3360963B1 (fr) 2010-11-12 2019-11-06 Gen9, Inc. Procédés et dispositifs pour la synthèse d'acides nucléiques
WO2012067901A1 (fr) 2010-11-15 2012-05-24 Life Technologies Corporation Méthodes et kits d'amplification multiplexe de locus de répétitions courtes en tandem
AU2011330768A1 (en) 2010-11-15 2013-05-30 Merz Pharma Gmbh & Co. Kgaa Dipeptide analogs for treating conditions associated with amyloid fibril formation
CN110016463A (zh) 2010-11-15 2019-07-16 艾克塞利瑞提德生物技术公司 由人类滋养层干细胞生成神经干细胞
US20130304390A1 (en) 2010-11-16 2013-11-14 Life Technologies Corporation Systems and Methods for the Analysis of Proximity Binding Assay Data
WO2012066495A2 (fr) 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority Thérapie à base de cellules t pour les maladies neurodégénératives
WO2012068400A2 (fr) 2010-11-17 2012-05-24 Asuragen, Inc. Micro-arn utilisés comme biomarqueurs pour faire la distinction entre des néoplasmes thyroïdiens bénins et malins
WO2012068340A2 (fr) 2010-11-18 2012-05-24 Opko Curna Llc Compositions d'antagonat et leurs méthodes d'utilisation
WO2012068383A2 (fr) 2010-11-19 2012-05-24 The Regents Of The University Of Michigan Arnnc et utilisations de celui-ci
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
EP2643463B1 (fr) 2010-11-23 2017-09-27 CuRNA, Inc. Traitement de maladies associées à nanog par l'inhibition d'un transcript antisens naturel de nanog
US8741640B2 (en) 2010-11-24 2014-06-03 Hong Gao Expanding hematopoietic stem cells
WO2012071039A1 (fr) 2010-11-24 2012-05-31 Pioner Hi-Bred International, Inc. Événement dp-061061-7 de brassica gat et compositions et procédés pour l'identifier et/ou le détecter
EA031629B1 (ru) 2010-11-24 2019-01-31 Пайонир Хай-Бред Интернэшнл, Инк. Событие gat dp-073496-4 brassica и композиции и способы для его идентификации и/или детектирования
US9308255B2 (en) 2010-11-24 2016-04-12 Yale University Methods of administering D-dopachrome tautomerase (D-DT) to treat ischemia-reperfusion injury
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2646569A1 (fr) 2010-11-30 2013-10-09 Diagon Kft. Procédure pour la détermination de nombres de germes bactériens par diagnostic moléculaire sur la base d'acides nucléiques, et trousse associée
US9574171B2 (en) 2010-12-02 2017-02-21 Technion Research & Development Foundation Ltd. Methods of generating corneal cells and cell populations comprising same
CA2819684C (fr) 2010-12-03 2024-05-07 Dow Agrosciences Llc Evenement 8264.44.06.1 de tolerance aux herbicides empile, lignees de soja transgeniques apparentees, et sa detection
WO2012075231A1 (fr) 2010-12-03 2012-06-07 Brandeis University Procédés et trousses pour la détection de mutants d'acide nucléique dans des populations de type sauvage
CN103298939A (zh) 2010-12-06 2013-09-11 夸克医药公司 包含位置修饰的双链寡核苷酸化合物
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
US20120183960A1 (en) 2010-12-07 2012-07-19 Enterologics, Inc. Method for identifying e. coli m-17
JP6126381B2 (ja) 2010-12-10 2017-05-10 国立大学法人東京工業大学 標的核酸の検出方法及びキット
GB201020982D0 (en) 2010-12-10 2011-01-26 Stiftung Offentlichen Rechts Polymorphism
WO2012102793A2 (fr) 2010-12-10 2012-08-02 Zirus, Inc. Gènes de mammifère impliqués dans la toxicité et l'infection
CN103492587B (zh) 2010-12-13 2015-02-18 生命技术公司 利用通过多磷酸分解作用(app)反应的活化聚合核酸
WO2012081029A1 (fr) 2010-12-15 2012-06-21 Kadimastem Ltd. Cellules produisant de l'insuline dérivées de cellules souches pluripotentes
TWI667347B (zh) 2010-12-15 2019-08-01 瑞士商先正達合夥公司 大豆品種syht0h2及偵測其之組合物及方法
JP6016800B2 (ja) 2010-12-15 2016-10-26 ワイス・エルエルシー 抗ノッチ1抗体
EP2465945A1 (fr) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Matrice générique pour acides nucléiques de contrôle
CN103501804A (zh) 2010-12-21 2014-01-08 雷科制药公司 眼泪替代物
WO2012086243A1 (fr) 2010-12-21 2012-06-28 株式会社 島津製作所 Dispositif et procédé de traitement d'un composant cible dans un tube
CA3095614A1 (fr) 2010-12-22 2012-06-28 Evogene Ltd. Polynucleotides et polypeptides isoles, et procedes d'utilisation de ceux-ci pour augmenter la tolerance vis-a-vis du stress abiotique, le rendement, le taux de croissance, la vigueur, la biomasse, la teneur en huile et/ou l'efficacite d'utilisation d'azote de plantes
AU2011349148C1 (en) 2010-12-22 2017-08-24 Pioneer Hi-Bred International, Inc. QTLs associated with and methods for identifying whole plant field resistance to Sclerotinia
WO2012088450A1 (fr) 2010-12-22 2012-06-28 Danisco Us Inc. Production biologique de sucres pentoses à l'aide de cellules recombinantes
SG191235A1 (en) 2010-12-22 2013-07-31 Danisco Us Inc Compositions and methods for improved isoprene production using two types of ispg enzymes
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
PE20140871A1 (es) 2010-12-27 2014-07-19 Lilly Co Eli COMPOSICIONES Y METODOS DE VACUNA DEL VIRUS TIPO 1b DE DIARREA VIRAL BOVINA
AR084358A1 (es) 2010-12-27 2013-05-08 Lilly Co Eli Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
CN103533947A (zh) 2010-12-28 2014-01-22 卡梅迪斯有限公司 用于治疗和预防感染的植物提取物
US9594870B2 (en) 2010-12-29 2017-03-14 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
CN103597093A (zh) 2010-12-29 2014-02-19 生命技术公司 作为荧光参考标准品的ddao化合物
US10241075B2 (en) 2010-12-30 2019-03-26 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
US20120174246A1 (en) 2010-12-30 2012-07-05 Chaky Julian M Methods of identifying aphid resistant soybeans
EP3582224A1 (fr) 2010-12-30 2019-12-18 Life Technologies Corporation Modèles pour analyser des données issues d'opérations de séquençage par synthèse
CN103443266A (zh) 2010-12-30 2013-12-11 纳幕尔杜邦公司 在解脂耶氏酵母中使用啤酒糖酵母suc2基因以利用蔗糖
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092376A2 (fr) 2010-12-31 2012-07-05 Short Jay M Génération d'anticorps monoclonaux entiers
EP4008781A1 (fr) 2010-12-31 2022-06-08 BioAtla, Inc. Humanisation express d'anticorps
BR112013017096A2 (pt) 2011-01-04 2020-09-01 Jennerex Inc. composição e métodos de indução de resposta citotóxica dependente de complemento mediado por anticorpo específico de tumor em animal tendo tumor, de geração de anticorpos in vivo, de inibição do crescimento ou morte de célula de câncer, para tratar indivíduo com câncer, para adaptar de terapia de câncer para indivíduo com câncer e para identificar antígeno específico de tumor
MX2017015093A (es) 2011-01-11 2023-03-10 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
EP2474617A1 (fr) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR pour traiter une nouvelle angiogenèse
WO2012097318A2 (fr) 2011-01-14 2012-07-19 Kap Abiosystems Adn polymérases modifiées destinées à améliorer l'amplification
EP2663639B1 (fr) 2011-01-14 2017-09-13 Life Technologies Corporation Procédés d'isolement, d'identification et de quantification des miarn
EP2665833B1 (fr) 2011-01-17 2017-04-19 Life Technologies Corporation Workflow pour la détection de ligands à l'aide d'acides nucléiques
US9211302B2 (en) 2011-01-17 2015-12-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulation of LRCH4 activity and therapeutic application thereof
ES2774190T3 (es) 2011-01-20 2020-07-17 Protalix Ltd Composiciones de alfa-galactosidasa
WO2012103031A2 (fr) 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Détection d'anomalies génétiques
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
EP2668299B1 (fr) 2011-01-26 2018-03-07 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Détection sélective de haemophilus influenzae
US9738930B2 (en) 2011-01-28 2017-08-22 The Broad Institute, Inc. Paired end bead amplification and high throughput sequencing
WO2012104851A1 (fr) 2011-01-31 2012-08-09 Yeda Research And Development Co. Ltd. Méthodes de diagnostic d'une maladie utilisant une pcr d'extension-chevauchement
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
AU2012212127B2 (en) 2011-02-02 2016-06-02 Exact Sciences Corporation Digital sequence analysis of DNA methylation
MX342927B (es) 2011-02-03 2016-10-19 Mirna Therapeutics Inc Mimeticos sinteticos de mir-34.
WO2012106586A1 (fr) 2011-02-03 2012-08-09 Mirna Therapeutics, Inc. Mimétiques synthétiques de mir-124
WO2012109238A2 (fr) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Procédés d'augmentation des réponses immunitaires à l'aide d'agents qui se lient directement à ire-1 et activent ire-1
US8952132B2 (en) 2011-02-07 2015-02-10 Research Development Foundation Engineered immunoglobulin FC polypeptides
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
WO2012108864A1 (fr) 2011-02-08 2012-08-16 Illumina, Inc. Enrichissement sélectif d'acides nucléiques
US9574179B2 (en) 2011-02-08 2017-02-21 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming
FR2971257B1 (fr) 2011-02-09 2020-12-04 Bio Rad Pasteur Combinaison de biomarqueurs pour le pronostic d'une reponse ou non-reponse a un traitement anti-vhc
FR2971256A1 (fr) 2011-02-09 2012-08-10 Bio Rad Pasteur Combinaison de biomarqueurs pour la detection et l'evaluation d'une fibrose hepatique
FR2971258B1 (fr) 2011-02-09 2020-12-04 Bio Rad Pasteur Combinaison de biomarqueurs pour le pronostic d'une reponse ou non-reponse a un traitement anti-vhc
EP2673363B1 (fr) 2011-02-11 2017-08-23 The Rockefeller University Traitement de troubles d'angiogenèse
EP2673614B1 (fr) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Procédé de formation de gouttelettes mélangées
EP2673382B1 (fr) 2011-02-11 2020-05-06 Bio-Rad Laboratories, Inc. Dispositif de thermocyclage pour l'amplification des acides nucléiques et procédés d'utilisation
US10245255B2 (en) 2011-02-14 2019-04-02 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
MX2013009357A (es) 2011-02-14 2014-02-17 Theraclone Sciences Inc Composiciones y metodos para la terapia y diagnostico de la influenza.
JP5847201B2 (ja) 2011-02-15 2016-01-20 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 増大した3’末端ミスマッチ識別能を有するdnaポリメラーゼ
EP2675913B1 (fr) 2011-02-15 2016-12-14 Bio-Rad Laboratories, Inc. Détection de méthylation dans une sous-population d'adn génomique
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
WO2012110843A1 (fr) 2011-02-18 2012-08-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour promouvoir la fibrinolyse et la thrombolyse
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
JP2014509846A (ja) 2011-02-18 2014-04-24 デュポン ニュートリション バイオサイエンシス エーピーエス 飼料添加用組成物
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US10301064B2 (en) 2011-02-22 2019-05-28 Universal Bio Research Co., Ltd. Reaction container and method for producing same
WO2012116040A1 (fr) 2011-02-22 2012-08-30 OSI Pharmaceuticals, LLC Marqueurs biologiques prédictifs d'une réponse anticancéreuse aux inhibiteurs de la kinase du récepteur du facteur de croissance 1 analogue à l'insuline dans le carcinome hépatocellulaire
WO2012114234A1 (fr) 2011-02-23 2012-08-30 Dupont Nutrition Biosciences Aps Procédé
EP2492687A1 (fr) 2011-02-23 2012-08-29 Institut Gustave Roussy -Igr- MYH10 en tant que nouveau marqueur de diagnostic des pathologies résultant d'une inactivation de RUNX1
WO2012114231A2 (fr) 2011-02-23 2012-08-30 Dupont Nutrition Biosciences Aps Procédé
US20130330349A1 (en) 2011-02-23 2013-12-12 Rappaport Family Institute For Research In The Medical Sciences High affinity molecules capable of binding a type a plexin receptor and uses of same
EP2492354A1 (fr) 2011-02-23 2012-08-29 Institut National De La Recherche Agronomique (INRA) Procédé d'identification de composés utiles dans le traitement de l'épilepsie réflexe photosensible
WO2012114232A1 (fr) 2011-02-23 2012-08-30 Dupont Nutrition Biosciences Aps Procédé
CN103403533B (zh) 2011-02-24 2017-02-15 简.探针公司 用于分辨光信号检测器中不同调制频率的光信号的系统和方法
RU2564122C2 (ru) 2011-02-24 2015-09-27 Хилл'С Пет Ньютришн, Инк. Способ и набор для диагностики гломерулонефрита у кошки
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
US20120219950A1 (en) 2011-02-28 2012-08-30 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
WO2012117406A2 (fr) 2011-03-02 2012-09-07 Futuragene Israel Ltd. Plantes transgéniques résistantes aux bactéries
WO2012119129A1 (fr) 2011-03-02 2012-09-07 Berg Biosystems, Llc Analyses par interrogation, basées sur des cellules et utilisations correspondantes
EP2680839A1 (fr) 2011-03-02 2014-01-08 Morphotek, Inc. Co-administration d'éribuline et de farletuzumab pour le traitement du cancer du sein
US9796979B2 (en) 2011-03-03 2017-10-24 Quark Pharmaceuticals Inc. Oligonucleotide modulators of the toll-like receptor pathway
SG193280A1 (en) 2011-03-03 2013-10-30 Quark Pharmaceuticals Inc Oligonucleotide modulators of the toll-like receptor pathway
EP2680864B1 (fr) 2011-03-03 2019-05-08 Ramot at Tel-Aviv University Ltd. Cellules musculaires génétiquement modifiées qui expriment des facteurs neurotrophiques
ITVT20110002A1 (it) 2011-03-03 2011-06-02 Molecular Digital Diagnostics S R L Metodo di determinazione dell'origine di fluidi o tracce biologiche e kit di reagenti per la loro identificazione in un campione.
MX346663B (es) 2011-03-06 2017-03-27 Merck Serono Sa Lineas de celulas de bajo nivel de fucosa y usos de las mismas.
US9061006B2 (en) 2011-03-08 2015-06-23 Ramot At Tel-Aviv University Ltd. Compositions and methods for diagnosing and treating phenylketonuria (PKU)
DK3270141T3 (da) 2011-03-08 2020-08-24 UNIVERSITé LAVAL Fluidcentripetalindretning
US9057107B2 (en) 2011-03-08 2015-06-16 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
EP2683833B1 (fr) 2011-03-10 2018-09-26 Gen-Probe Incorporated Procédés de sélection et d'optimisation de séquences de marquage oligonucléotidiques
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
AU2012229123B2 (en) 2011-03-15 2017-02-02 British Columbia Cancer Agency Branch Methods of treating breast cancer with anthracycline therapy
JP2014509591A (ja) 2011-03-15 2014-04-21 セラクローン サイエンシーズ, インコーポレイテッド インフルエンザの治療および診断のための組成物および方法
EP2686348B1 (fr) 2011-03-17 2015-12-30 Ramot at Tel-Aviv University Ltd. Anticorps asymétriques, bispécifiques et monospécifiques et procédés de génération de ceux-ci
US20140086839A1 (en) 2011-03-17 2014-03-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
EP2686677B1 (fr) 2011-03-18 2018-10-03 Stichting VUmc Une méthode d'analyse d'un échantillon de sang pour la présence d'un marqueur de la maladie
SG193489A1 (en) 2011-03-18 2013-10-30 Eisai R&D Man Co Ltd Methods and compositions for predicting response to eribulin
WO2012127320A1 (fr) 2011-03-22 2012-09-27 Pluristem Ltd. Procédés de traitement de blessures dues aux expositions aux irradiations ou aux produits chimiques
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
WO2012129330A1 (fr) 2011-03-23 2012-09-27 Option Pharmaceutical, Llc Cytokine ciblée pour le traitement de maladies musculosquelettiques
WO2012129363A2 (fr) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Détection et analyse d'acide nucléique d'une cellule isolée
KR20140036164A (ko) 2011-03-24 2014-03-25 뉴림 파머슈티칼스 (1991) 리미티드 신경보호 펩타이드
EP2689014B1 (fr) 2011-03-24 2019-04-24 Butamax (TM) Advanced Biofuels LLC Cellules hôtes et procédés de production d'isobutanol
WO2012135053A2 (fr) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Essais à base d'arnase h faisant appel à des monomères d'arn modifiés
WO2012129758A1 (fr) 2011-03-25 2012-10-04 Biomerieux Procédé et kit pour déterminer in vitro la probabilité qu'un individu soit atteint d'un cancer colorectal
WO2012131680A2 (fr) 2011-03-28 2012-10-04 Yeda Research And Development Co. Ltd. Compositions et procédés pour le traitement de l'inflammation
JP5852222B2 (ja) 2011-03-29 2016-02-03 シージーン アイエヌシー Pto切断及び延長−依存的切断によるターゲット核酸配列の検出
US9777332B2 (en) 2011-03-31 2017-10-03 St. Jude Children's Research Hospital Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
DK2691541T3 (en) 2011-03-31 2018-01-22 Dana Farber Cancer Inst Inc PROCEDURE FOR ENRICHMENT OF SINGLE DRAWED MUTANTS SEQUENCES FROM A MIXTURE OF WILD TYPE AND MUTANTS
WO2012135773A1 (fr) 2011-03-31 2012-10-04 E. I. Du Pont De Nemours And Company Régions promotrices de diacylglycérol acyltransférase d'yarrowia pour l'expression du gène dans la levure
WO2012135777A1 (fr) 2011-04-01 2012-10-04 E. I. Du Pont De Nemours And Company Régions de promoteur d'estérase/lipase de yarrowia pour l'expression de gènes dans des levures
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
WO2012137202A1 (fr) 2011-04-05 2012-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprenant un indicateur de fer attaché à une microparticule et utilisations de celle-ci pour quantifier du fer non lié à la transferrine (ntbi) et du fer labile cellulaire (lci)
ES2650721T3 (es) 2011-04-05 2018-01-22 Dow Agrosciences Llc Análisis de alto rendimiento de los bordes transgénicos
US8735094B2 (en) 2011-04-05 2014-05-27 E I Du Pont De Nemours And Company Yarrowia n-alkane-hydroxylating cytochrome P450 promoter regions for gene expression in yeast
EP2694962B1 (fr) 2011-04-06 2017-03-01 Ramot at Tel-Aviv University Ltd. Méthodes de surveillance et d'analyse de profils de l'activité métabolique, utilisations diagnostiques et thérapeutiques de même
WO2012138570A2 (fr) 2011-04-06 2012-10-11 The Board Of Regents Of The University Of Texas System Modulation de polypeptides bactériens mam dans une maladie pathogène
US8609369B2 (en) 2011-04-07 2013-12-17 E I Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
US20140031272A1 (en) 2011-04-08 2014-01-30 Danisco Us Inc. Compositions
EP2694675B1 (fr) 2011-04-08 2018-01-24 Life Technologies Corporation Ordonnancements d'écoulement de réactif de protection de phase pour l'utilisation dans un séquençage-par-synthèse
US20120328567A1 (en) 2011-04-08 2012-12-27 Steven Bushnell Biomarkers predictive of therapeutic responsiveness to ifnb and uses thereof
WO2012136653A1 (fr) 2011-04-08 2012-10-11 Novvac Aps Protéines et acides nucléiques utiles dans des vaccins ciblant le staphylococcus aureus
EP2694670B1 (fr) 2011-04-08 2017-07-19 Bio-Rad Laboratories, Inc. Mélanges de réaction pcr à activité non spécifique réduite
WO2012139748A1 (fr) 2011-04-11 2012-10-18 Roche Diagnostics Gmbh Adn polymérases avec une activité améliorée
EP2697387B1 (fr) 2011-04-12 2021-09-15 Bactoclear Holdings PTE. LTD. Polypeptides chimères antibactériens
WO2012142164A1 (fr) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anticorps monoclonaux humains qui se lient aux facteurs de croissance insulinomimétique (igf) de type i et ii
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US20140157443A1 (en) 2011-04-14 2014-06-05 St. Jude Children's Research Hospital Methods and compositions for detecting and modulating a novel mtor complex
CA2832812C (fr) 2011-04-15 2017-12-05 Pluristem Ltd. Procedes et systemes de recolte de cellules
EP2697657B8 (fr) 2011-04-15 2017-08-16 Becton, Dickinson and Company Thermocycleur microfluidique en temps réel à balayage et procédés synchronisés de thermocyclage et de détection optique à balayage
DK2699700T3 (en) 2011-04-20 2016-08-01 Mesa Biotech Inc Integrated device for nukleinsyreregistrering and identification
GB201106814D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compounds
US20150306139A1 (en) 2011-04-21 2015-10-29 Jeffrey Ravetch Anti-inflammatory agents
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
AU2012249751B2 (en) 2011-04-25 2016-11-03 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
EP2701743A4 (fr) 2011-04-27 2015-08-19 Univ Northwestern Anticorps sélectifs pour des dimères pathologiques de tau et des oligomères pathologiques pré-fibrillaires de tau et leur utilisation dans le traitement, le diagnostic et la surveillance de tauopathies
WO2012149438A1 (fr) 2011-04-28 2012-11-01 Life Technologies Corporation Procédés et compositions pour pcr multiplexe
EP2702159B1 (fr) 2011-04-28 2018-07-25 St. Jude Children's Research Hospital Virus sendai modifié comme vaccin et vecteur d'imagerie
EP2702146B1 (fr) 2011-04-28 2018-11-28 The Board of Trustees of The Leland Stanford Junior University Identification de polynucléotides associés à un échantillon
US10172305B2 (en) 2011-04-29 2019-01-08 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
EA201391585A1 (ru) 2011-04-29 2014-04-30 Юниверсити Оф Вашингтон Терапевтические нуклеазные композиции и способы
US8460872B2 (en) 2011-04-29 2013-06-11 Sequenom, Inc. Quantification of a minority nucleic acid species
US9677084B2 (en) 2011-04-29 2017-06-13 Pioneer Hi-Bred International, Inc. Down-regulation of a homeodomain-leucine zipper I-class homeobox gene for improved plant performance
US9856534B2 (en) 2011-04-29 2018-01-02 Emory University Selecting use of proteasome inhibitors based on NF-κB2 sequence
US8728798B2 (en) 2011-05-03 2014-05-20 Verdezyne, Inc. Biological methods for preparing adipic acid
US8343752B2 (en) 2011-05-03 2013-01-01 Verdezyne, Inc. Biological methods for preparing adipic acid
EP2520658B1 (fr) 2011-05-03 2015-10-07 Dow AgroSciences LLC Amélioration de la production de spinosyne avec des protéines de liaison avec l'oxygène
BR112013028383B1 (pt) 2011-05-03 2021-10-13 Evogene Ltd Método para aumento do rendimento de sementes, biomassa, teor de óleo e/ou resistência à deficiência de nitrogênio de uma planta
US9192670B2 (en) 2011-05-04 2015-11-24 Ramot At Tel-Aviv University Ltd. Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease
WO2012151480A2 (fr) 2011-05-05 2012-11-08 The Procter & Gamble Company Compositions et procédés comportant des variants de protéases à sérine
RU2718648C2 (ru) 2011-05-05 2020-04-10 ДАНИСКО ЮЭс ИНК. Композиции и способы, включающие варианты сериновой протеазы
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2012153333A1 (fr) 2011-05-09 2012-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Régénération et réparation de tissu mésenchymateux par utilisation d'amélogénine
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
WO2012153153A1 (fr) 2011-05-11 2012-11-15 Diagon Kft. Procédé de détermination rapide de virus à l'aide de diagnostics moléculaires basés sur des acides nucléiques, et trousse pour sa mise en œuvre
WO2012153336A2 (fr) 2011-05-12 2012-11-15 Rakuto Bio Technologies Ltd. Procédés et dispositifs pour éclaircir la carnation de la peau
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
ES2773692T3 (es) 2011-05-12 2020-07-14 Exact Sciences Corp Aislamiento de ácidos nucleicos
WO2012156976A1 (fr) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés de préparation d'artémisinine dans des plantes non-hôtes et vecteurs destinés à une utilisation dans celles-ci
CN107936121B (zh) 2011-05-16 2022-01-14 埃泰美德(香港)有限公司 多特异性fab融合蛋白及其使用方法
US8663919B2 (en) 2011-05-18 2014-03-04 Life Technologies Corporation Chromosome conformation analysis
US9119824B2 (en) 2011-05-18 2015-09-01 Memorial Sloan-Kettering Cancer Center Methods of use for IL-22 promoting rejuvenation of thymic and bone marrow function
WO2012162179A1 (fr) 2011-05-20 2012-11-29 Oligomerix, Inc. Compositions de protéase tau et procédés d'utilisation
EP2710172B1 (fr) 2011-05-20 2017-03-29 Fluidigm Corporation Réactions d'encodage d'acide nucléique
US10435743B2 (en) 2011-05-20 2019-10-08 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
EP2715350B1 (fr) 2011-05-23 2017-09-27 Yeda Research and Development Co. Ltd. Utilisation de la phosphorylation d'akt en tant que biomarqueur pour le pronostic et le traitement de maladies neurodégénératives
WO2012160526A2 (fr) 2011-05-23 2012-11-29 Ofir Menashe Formulations à base de particules contenant des micro-organismes et leurs utilisations
EP2714939B1 (fr) 2011-05-24 2015-04-15 Elitech Holding B.V. Détection de staphylococcus aureus résistant à la méthicilline
WO2012160448A2 (fr) 2011-05-25 2012-11-29 Innate Pharma, S.A. Anticorps anti-kir destinés au traitement de troubles inflammatoires
JP2014516537A (ja) 2011-05-26 2014-07-17 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 組換え油性微生物における、その中のオイル含量を増加させるためのカレオシンの発現
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
WO2012165943A1 (fr) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Procédé d'analyse d'un échantillon de sang prélevé chez un sujet en vue de rechercher un marqueur d'une maladie infectieuse
JP6169567B2 (ja) 2011-05-31 2017-07-26 ハチソン バイオフィルム メディカル ソリューションズ リミテッド 細胞集塊の分散及び脱離
US20140113376A1 (en) 2011-06-01 2014-04-24 Rotem Sorek Compositions and methods for downregulating prokaryotic genes
US9737891B2 (en) 2011-06-01 2017-08-22 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (fr) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Quantification d'enzyme
WO2012169887A2 (fr) 2011-06-06 2012-12-13 Stichting Katholieke Universiteit, More Particularly The Radboud University Nijmegen Medical Centre Utilisation de nouveaux marqueurs dans un dosage de diagnostic pour la détermination de la sévérité d'une infection par rsv
WO2012167382A1 (fr) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions et procédés pour le traitement du glioblastome
WO2012170793A1 (fr) 2011-06-08 2012-12-13 Metabolix, Inc. Processus de bioraffinage pour la production de thf
ES2955849T3 (es) 2011-06-08 2023-12-07 Life Technologies Corp Diseño y desarrollo de detergentes novedosos para su uso en sistemas de PCR
US9567628B2 (en) 2011-06-08 2017-02-14 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
KR102043422B1 (ko) 2011-06-09 2019-11-11 큐알엔에이, 인크. 프라탁신 (fxn)에 대한 자연 안티센스 전사체의 저해에 의한 프라탁신 (fxn) 관련된 질환의 치료
US9415103B2 (en) 2011-06-14 2016-08-16 Yeda Research And Development Co. Ltd. Combination therapy to prevent DCIS formation and progression to breast cancer
US10144969B2 (en) 2011-06-15 2018-12-04 Colgate-Palmolive Company Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
EP2535712A1 (fr) 2011-06-15 2012-12-19 F. Hoffmann-La Roche AG Système analytique pour la préparation d'un matériau biologique
PT2535424E (pt) 2011-06-16 2015-10-29 Gendiag Exe Sl Snps associados a doença tromboembólica
WO2012174119A2 (fr) 2011-06-17 2012-12-20 Life Technologies Corporation Compositions et procédés de détection d'espèces et souches de cronobacter spp. et de cronobacter
BR112013032320A2 (pt) 2011-06-17 2016-12-20 Butamax Advanced Biofuels Llc método e composição de produção de butanol, composição de butanol e isobutanol, método de cultivo de um micro-organismo produtor de butanol em material lignocelulósico e método para inibir o crescimento de micro-organismos que não produzem butanol em uma composição
CN103608030A (zh) 2011-06-21 2014-02-26 昂科发克特公司 用于治疗和诊断癌症的组合物和方法
US20140275211A1 (en) 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
US8470573B2 (en) 2011-06-21 2013-06-25 Bio-Rad Laboratories, Inc. Hybrid polymerases having the ability to produce long amplicons
WO2012178007A1 (fr) 2011-06-22 2012-12-27 Yale University Compositions et procédés de diagnostic de maladies et de troubles associés à la mort de cellules β
US9988668B2 (en) 2011-06-23 2018-06-05 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
RU2014101662A (ru) 2011-06-23 2015-07-27 Каиима Био Агритех Лтд. Мягкая пшеница, растения или их части с частично или полностью мультиплицированным геномом, гибриды и их продукты, а также способы их получения и применения
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
GB201110833D0 (en) 2011-06-24 2011-08-10 Bold Venture Llc Compositions
WO2013003647A2 (fr) 2011-06-28 2013-01-03 Sea Lane Biotechnologies, Llc Protéines de liaison à domaines variables empilés polyvalentes
WO2013003630A2 (fr) 2011-06-28 2013-01-03 Igor Kutyavin Procédés et compositions pour enrichissement d'acides nucléiques dans des mélanges de séquences fortement homologues
IN2014CN00650A (fr) 2011-06-30 2015-04-03 Novozymes As
JP6208658B2 (ja) 2011-07-05 2017-10-04 バイオアシス テクノロジーズ インコーポレイテッド p97−抗体結合体および使用方法
CA2841794C (fr) 2011-07-06 2019-08-13 Verdezyne, Inc. Levure genetiquement modifiee presentant une activite de deshydrogenase d'alcool augmentee destinee a la preparation d'acide gras dicarboxylique
JP2014520551A (ja) 2011-07-11 2014-08-25 セルラー ダイナミクス インターナショナル, インコーポレイテッド 細胞のリプログラミング方法およびゲノムの改変方法
WO2013055420A2 (fr) 2011-07-12 2013-04-18 Philadelphia Health & Education Corporation Nouveau vaccin à adn dirigé contre clostridium difficile
WO2013009971A1 (fr) 2011-07-12 2013-01-17 E. I. Du Pont De Nemours And Company Procédé de détection et de criblage et matériaux utiles dans l'exécution de celui-ci
KR101264295B1 (ko) 2011-07-13 2013-07-04 연세대학교 산학협력단 타겟 핵산서열의 계층적 제조방법
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
WO2013012733A1 (fr) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Régions fc hétérodimères, molécules de liaison les comprenant, et méthodes associées
CA3113828A1 (fr) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions et procedes de detection de l'acide nucleique du parvovirus humain et de detection des acides nucleiques du virus de l'hepatite a dans des dosages monoplexes ou multiplexes
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013011507A1 (fr) 2011-07-20 2013-01-24 Kaiima Bio Agritech Ltd. Plantes de maïs ayant un génome partiellement ou totalement multiplié et utilisations de celles-ci
GB201112622D0 (en) 2011-07-22 2011-09-07 Ucl Business Plc Pathogen screening
BR102012019434B1 (pt) 2011-07-26 2021-11-09 Dow Agrosciences Llc Métodos de controle de pestes, de insetos, molécula e sequência de dna diagnóstica para o evento de soja 9582.814.19.1
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術
EP2550982A1 (fr) 2011-07-27 2013-01-30 Technion Research & Development Foundation Ltd. Dispositifs pour applications chirurgicales
US9090883B2 (en) 2011-07-28 2015-07-28 Roche Molecular Systems, Inc. DNA polymerases with improved activity
EP2736928B1 (fr) 2011-07-28 2019-01-09 i2 Pharmaceuticals, Inc. Proteines "sur"-liantes dirigees contre erbb3
CN107400711A (zh) 2011-08-03 2017-11-28 伯乐实验室公司 使用透化处理的细胞过滤小核酸
HUE044154T2 (hu) 2011-08-04 2019-09-30 Yeda Res & Dev MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezelésére
PT2739649T (pt) 2011-08-05 2018-01-03 Bioasis Technologies Inc Fragmentos de p97 com atividade de transferência
EP2554679B1 (fr) 2011-08-05 2016-03-02 Gendiag.exe, S.L. marqueur génétique pour le risque d'une maladie cardiovasculaire
US20140256590A1 (en) 2011-08-09 2014-09-11 Vereniging Voor Christelijk Hoger Onderwijs Method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
WO2013021389A2 (fr) 2011-08-09 2013-02-14 Yeda Research And Development Co.Ltd. Régulation à la baisse de mir-7 pour favoriser la différenciation des cellules bêta et la production d'insuline
BR112014002859A2 (pt) 2011-08-10 2017-06-13 Metabolix Inc purificação pós-processamento para produção de gama-butiro lactona
US20140271680A1 (en) 2011-08-12 2014-09-18 Universite Paris-Est Creteil Val De Marne Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CA2844028A1 (fr) 2011-08-14 2013-02-21 Kaiima Bio Agritech Ltd. Plantes de ble dur ayant un genome partiellement ou completement multiplie, et leurs utilisations
WO2013024173A1 (fr) 2011-08-17 2013-02-21 Technische Universität München Procédé mis en œuvre par ordinateur pour l'indentification de régions régulatrices ou de variations régulatrices
US8759618B2 (en) 2011-08-17 2014-06-24 Stine Seed Farm, Inc. Maize event HCEM485, compositions and methods for detecting and use thereof
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
EP4324935A3 (fr) 2011-08-18 2024-05-08 Life Technologies Corporation Procédés, systèmes et supports lisibles par ordinateur pour effectuer des appels de base dans le séquençage d'acides nucléiques
ES2680143T3 (es) 2011-08-24 2018-09-04 Oxoid Limited Composiciones y métodos para la detección de múltiples microorganismos
LT3594340T (lt) 2011-08-26 2021-10-25 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
US8822651B2 (en) 2011-08-30 2014-09-02 Theraclone Sciences, Inc. Human rhinovirus (HRV) antibodies
EP3517615B1 (fr) 2011-08-31 2022-05-04 Seminis Vegetable Seeds, Inc. Procédés et compositions assurant la fermeté des pastèques
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
JP2014527801A (ja) 2011-09-01 2014-10-23 ユニバーシティ オブ サザン カリフォルニア ハイスループットペプチドミメティックを調製するための方法、経口バイオアベイラブルな薬物およびそれを含有する組成物
BR112014005234A2 (pt) 2011-09-06 2017-04-11 Curna Inc tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
EP4219740A3 (fr) 2011-09-06 2023-08-16 Gen-Probe Incorporated Structures fermées d'acide nucléique
EP2753714B1 (fr) 2011-09-06 2017-04-12 Gen-Probe Incorporated Gabarits mis sous forme circulaire pour séquençage
US9959392B2 (en) 2011-09-07 2018-05-01 Yeda Research And Development Co. Ltd. Olfactory signature and odorant mixture having the same
SG11201400513PA (en) 2011-09-08 2014-06-27 Yeda Res & Dev Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
JP5299981B1 (ja) 2011-09-08 2013-09-25 独立行政法人理化学研究所 プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法
WO2013035071A1 (fr) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Nouveaux biomarqueurs de risque pour le cancer du poumon
WO2013036928A1 (fr) 2011-09-08 2013-03-14 Gen-Probe Incorporated Compositions et procédés de détection d'acide nucléique bactérien associé à la vaginose bactérienne
EP2763540A4 (fr) 2011-09-09 2015-04-22 Univ Yale Compositions et procédés d'évaluation et de traitement de maladies et de troubles inflammatoires
WO2013036799A2 (fr) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Procédés et compositions impliquant des inhibiteurs du nkg2d et le cancer
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
UA116089C2 (uk) 2011-09-13 2018-02-12 Монсанто Текнолоджи Ллс Спосіб та композиція для боротьби з бур'янами (варіанти)
CN104160028A (zh) 2011-09-13 2014-11-19 孟山都技术公司 用于杂草控制的方法和组合物
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
WO2013040116A1 (fr) 2011-09-13 2013-03-21 Monsanto Technology Llc Procédés et compositions de lutte contre les mauvaises herbes
CN107739737A (zh) 2011-09-13 2018-02-27 孟山都技术公司 用于杂草控制的方法和组合物
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
WO2013040251A2 (fr) 2011-09-13 2013-03-21 Asurgen, Inc. Méthodes et compositions incluant mir-135b, permettant de faire la distinction entre un cancer du pancréas et une maladie pancréatique bénigne
US8969519B2 (en) 2011-09-13 2015-03-03 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
EP2756101B1 (fr) 2011-09-15 2018-05-23 David A. Shafer Compositions sonde: anti-sonde pour une détection d'adn ou d'arn à spécificité élevée
EP2570487A1 (fr) 2011-09-16 2013-03-20 Lexogen GmbH Procédé de transcription d'acide nucléique
DK2756098T3 (en) 2011-09-16 2018-09-03 Lexogen Gmbh Process for Preparing a Library of Nucleic Acid Molecules
AU2012312169B2 (en) 2011-09-21 2016-01-14 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
CN107267615A (zh) 2011-09-23 2017-10-20 霍夫曼-拉罗奇有限公司 G形夹用于改进的等位基因特异性pcr的用途
AU2012315852B2 (en) 2011-09-28 2018-03-01 Qualicon Diagnostics, Llc Sequences and their use for detection and characterization of STEC bacteria
ES2602072T3 (es) 2011-09-29 2017-02-17 Trovagene, Inc. Mutaciones en SF3B1 y leucemia linfocítica crónica
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2761305B1 (fr) 2011-09-30 2017-08-16 Becton, Dickinson and Company Bandelette réactive unitisée
WO2013048661A1 (fr) 2011-09-30 2013-04-04 Codexis, Inc. Protéases fongiques
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
US20130090329A1 (en) 2011-10-07 2013-04-11 Suregene, Llc Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature
WO2013050453A1 (fr) 2011-10-07 2013-04-11 Baxter Healthcare S.A. Oxmif en tant que marqueur de diagnostic
US9575073B2 (en) 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013054320A1 (fr) 2011-10-11 2013-04-18 Tel Hashomer Medical Research Infrastructure And Services Ltd. Anticorps dirigés contre la molécule d'adhésion cellulaire associée à l'antigène carcino-embryonnaire (ceacam)
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
US9273102B2 (en) 2011-10-12 2016-03-01 Niels Iversen Møller Peptides derived from Campylobacter jejuni and their use in vaccination
CA2851838A1 (fr) 2011-10-13 2013-04-18 Boston Heart Diagnostics Corporation Compositions et methodes de traitement et de prevention d'une coronaropathie
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
CA2852665A1 (fr) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Methodes d'identification de mutations associees a des maladies
TWI607090B (zh) 2011-10-18 2017-12-01 陶氏農業科學公司 用於檢測植物中芳氧基烷酸酯二氧合酶基因(aad-12)的物質和方法
CA2792804A1 (fr) 2011-10-18 2013-04-18 Dow Agrosciences Llc Materiaux et methodes de detection du gene codant pour l'aryloxyalkanoate dioxygenase (aad-12) dans un evenement pdab4472-1606 dans les plantes
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
WO2013103434A1 (fr) 2011-10-19 2013-07-11 Harrisvaccines, Inc. Procédés et compositions pour protéger les invertébrés aquatiques contre les maladies
AU2012324791B2 (en) 2011-10-20 2016-04-14 Qiagen Gmbh Method for verifying a temperature measurement in a micro-environment and system for verifying a temperature measurement in a micro-environment
CA2853088C (fr) 2011-10-21 2018-03-13 Adaptive Biotechnologies Corporation Quantification de genomes de cellules immunitaires adaptatives dans un melange complexe de cellules
RU2639508C2 (ru) 2011-10-21 2017-12-21 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Способ определения зиготности гена fad-2 канолы с использованием пцр с детекцией по конечной точке
NO3051026T3 (fr) 2011-10-21 2018-07-28
RU2630998C2 (ru) 2011-10-21 2017-09-15 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Способ определения зиготности гена fad3 в каноле
US9518303B2 (en) 2011-10-25 2016-12-13 The Board Of Regents Of The University Of Texas System Methods and compositions for identifying enterovirus
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771464B1 (fr) 2011-10-27 2018-03-21 Yeda Research and Development Co. Ltd. Procédés de traitement du cancer
EP4345161A3 (fr) 2011-10-28 2024-06-12 Danisco Us Inc Variants d'alpha-amylase formant des variants de maltohexaose
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
ES2776144T3 (es) 2011-10-28 2020-07-29 Millennium Pharm Inc Biomarcadores de respuesta a inhibidores de NAE
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
BR112014010769B1 (pt) 2011-11-03 2021-08-03 Quark Pharmaceuticals, Inc Uso de um composto de rna de fita dupla para preparar um medicamento para tratar doença de ménière
EP2773892B1 (fr) 2011-11-04 2020-10-07 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
JP2014533100A (ja) 2011-11-04 2014-12-11 オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf 結腸直腸癌の分析のための方法およびバイオマーカー
EP2773757B1 (fr) 2011-11-04 2019-01-09 Gen-Probe Incorporated Réactifs et méthodes de dosage moléculaire
BR112014011044A2 (pt) 2011-11-07 2017-04-25 Beckman Coulter Inc amortecimento magnético para sistema de transporte de espécime
WO2013070754A1 (fr) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Bras robotique
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター, インコーポレイテッド 等分機システムおよびワークフロー
EP2776843B1 (fr) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Système de centrifugeuse et flux de travail
BR112014011043A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter Inc detecção de recipiente de espécime
EP2776565A1 (fr) 2011-11-08 2014-09-17 Quark Pharmaceuticals, Inc. Méthodes et compositions destinées à traiter des maladies, des troubles ou une lésion du système nerveux
BR112014011094A2 (pt) 2011-11-09 2018-08-07 Du Pont método para detectar a presença de salmonella, polinucletídeo isolado, kit e comprimido reagente
WO2013071233A1 (fr) 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Procédés de détection d'agents infectieux et nouveau virus détecté par ces procédés
CA2954166A1 (fr) 2011-11-11 2013-05-16 Rinat Neuroscience Corp. Anticorps specifiques de trop-2 et leurs utilisations
EP2781597A4 (fr) 2011-11-17 2015-07-29 Kirin Holdings Kk Protéine présentant une activité de glycoalcaloïde biosynthase et gène codant pour celle-ci
US8332160B1 (en) 2011-11-17 2012-12-11 Amyris Biotechnologies, Inc. Systems and methods for engineering nucleic acid constructs using scoring techniques
JP2014533953A (ja) 2011-11-17 2014-12-18 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 治療用rnaスイッチ組成物及び使用方法
KR102095699B1 (ko) 2011-11-18 2020-04-02 알닐람 파마슈티칼스 인코포레이티드 트랜스티레틴(TTR) 관련 질병을 치료하기 위한 RNAi 제제, 조성 및 그의 사용방법
WO2013078019A1 (fr) 2011-11-22 2013-05-30 Dow Agrosciences Llc Analyses de matrices tridimensionnelles pour séquençage à haut débit
WO2013076729A1 (fr) 2011-11-23 2013-05-30 Danziger Dan Flower Farm Plantes de type otomeria
EP2782930B1 (fr) 2011-11-27 2018-07-11 Yeda Research and Development Co. Ltd. Méthodes de régulation de l'angiogenèse et compositions capables de réguler l'angiogenèse
WO2013082316A1 (fr) 2011-11-29 2013-06-06 Caliper Life Sciences, Inc. Systèmes et méthodes d'échantillonnage de produits d'amplification
WO2013081864A1 (fr) 2011-11-29 2013-06-06 Life Technologies Corporation Procédés et compositions pour une pcr multiplex
EP2966180B1 (fr) 2011-11-29 2017-08-16 Life Technologies Corporation Procédés et compositions pour pcr multiplexe
AU2012346861A1 (en) 2011-11-30 2014-06-19 AbbVie Deutschland GmbH & Co. KG Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
GB201120711D0 (en) 2011-12-01 2012-01-11 Univ Erasmus Medical Ct Method for classifying tumour cells
CA2857640C (fr) 2011-12-02 2021-11-16 Fate Therapeutics, Inc. Composition de cellules souches amelioree
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013082241A2 (fr) 2011-12-02 2013-06-06 Fate Therapeutics, Inc. Méthodes améliorées permettant de traiter l'ischémie
US9689029B2 (en) 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
WO2013086201A1 (fr) 2011-12-06 2013-06-13 Dowd Scot E Dosages universels ou à large plage et procédé de diagnostic spécifique d'échantillons à marquages multiples à l'aide d'un séquençage non optique
JP6224613B2 (ja) 2011-12-08 2017-11-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 改善された活性を有するdnaポリメラーゼ
EP2788481B1 (fr) 2011-12-08 2018-03-07 Roche Diagnostics GmbH Adn polymérases ayant une activité améliorée
ES2569723T3 (es) 2011-12-08 2016-05-12 F. Hoffmann-La Roche Ag Polimerasas de DNA con actividad mejorada
EP3034087B1 (fr) 2011-12-08 2018-03-14 Yeda Research and Development Co. Ltd. Cellules pulmonaires fétales de mammifères et leur utilisation thérapeutique
DK2788491T3 (en) 2011-12-09 2019-04-01 Danisco Us Inc RIBOSOMAL PROMOTERS FROM B. SUBTILIS FOR PROTEIN PRODUCTION IN MICRO-ORGANISMS
ES2867924T3 (es) 2011-12-09 2021-10-21 Adaptive Biotechnologies Corp Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
UA116097C2 (uk) 2011-12-11 2018-02-12 Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре Спосіб модуляції провідності устячка рослини
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2791352A1 (fr) 2011-12-14 2014-10-22 Astrazeneca AB Diagnostic de gabr-a2
JP6408380B2 (ja) 2011-12-19 2018-10-17 ヴァリー ヘルス システム 癌を患うリスクのある被検体を診断するための方法およびキット
JP6204374B2 (ja) 2011-12-19 2017-09-27 オプティカル・ダイアグノスティクス・リミテッド 培養下での微生物を識別するための分光学的な手段および方法
US20130189679A1 (en) 2011-12-20 2013-07-25 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013093921A1 (fr) 2011-12-20 2013-06-27 Collplant Ltd. Fibres de polymère synthétique enrobées de collagène
EP2607904B1 (fr) 2011-12-21 2020-01-15 Roche Diagnostics GmbH Procédé pour mettre un liquide au rebut dans un système d'analyse automatisé, unité d'un rack d'embouts de pipette et système d'analyse
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
CN104254395B (zh) 2011-12-22 2016-05-04 生命科技公司 用于分析物测定的序贯侧向流动毛细管装置
CN104093314A (zh) 2011-12-22 2014-10-08 耶达研究及发展有限公司 使用针对t/b细胞耗尽的特异性方案的用于稳定和长期植入的联合疗法
RU2014123030A (ru) 2011-12-22 2016-02-20 Ринат Ньюросайенс Корп. Антагонистические антитела против человеческого рецептора гормона роста и способы их применения
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
US9334491B2 (en) 2011-12-22 2016-05-10 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
WO2013093693A1 (fr) 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Anticorps spécifiques de staphylococcus aureus et leurs utilisations
EP2794867A1 (fr) 2011-12-22 2014-10-29 Danisco US Inc. Alpha-amylases variantes et leurs procédés d'utilisation
US9975956B2 (en) 2011-12-22 2018-05-22 I2 Pharmaceuticals, Inc. Surrogate binding proteins which bind DR4 and/or DR5
WO2013095132A1 (fr) 2011-12-22 2013-06-27 Interna Technologies B.V. Miarn pour le traitement du cancer de la tête et du cou
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
CA2858284A1 (fr) 2011-12-23 2013-06-27 Biomerieux Detection de souches variantes meca de staphylococcus aureus resistant a la methycilline
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
AR089461A1 (es) 2011-12-28 2014-08-27 Kaiima Bio Agritech Ltd Una planta de sorghum cultivada que tiene un genoma parcial o totalmente multiplicado y usos de la misma
US9631195B2 (en) 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
US9284574B2 (en) 2011-12-29 2016-03-15 Pioneer Hi Bred International Inc Rag-based selection methods for improving aphid resistance in soybeans
EP2798071A2 (fr) 2011-12-30 2014-11-05 Butamax Advanced Biofuels LLC Interrupteurs génétiques utilisables en vue de la production de butanol
MX353954B (es) 2011-12-30 2018-02-07 Somalogic Inc Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf).
CA2861613A1 (fr) 2011-12-30 2013-07-04 Butamax Advanced Biofuels Llc Production d'alcools par fermentation
CA2858336A1 (fr) 2012-01-01 2013-07-04 Qbi Enterprises Ltd. Particules ciblant endo180 pour l'administration selective d'agents therapeutiques et diagnostiques
EP2802673B1 (fr) 2012-01-09 2019-07-03 Oslo Universitetssykehus HF Procédés et biomarqueurs pour l'analyse d'un cancer colorectal
CN111499760A (zh) 2012-01-12 2020-08-07 比奥贝拉蒂治疗公司 嵌合因子viii多肽及其用途
KR20140111673A (ko) 2012-01-12 2014-09-19 쿠아크 파마수티칼스 인코퍼레이티드 청력 및 균형 장애를 치료하기 위한 조합요법
WO2013104660A1 (fr) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Procédé de traitement d'une huile végétale comprenant l'hydrolyse de chlorophylle ou d'un dérivé de chlorophylle et une neutralisation caustique partielle
WO2013104659A2 (fr) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Procédé
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
AU2013209512B2 (en) 2012-01-20 2017-08-03 I2 Pharmaceuticals, Inc. Surrobody cojugates
PL2805280T3 (pl) 2012-01-20 2022-11-21 Sequenom, Inc. Procesy diagnostyczne będące czynnikiem warunków doświadczalnych
CN107043816A (zh) 2012-01-23 2017-08-15 陶氏益农公司 除草剂耐受性棉花事件pDAB4468.19.10.3
CA2863083C (fr) 2012-01-26 2023-09-19 Longhorn Vaccines And Diagnostics, Llc Sequences et vaccins antigeniques composites
WO2013114363A2 (fr) 2012-01-30 2013-08-08 Yeda Research And Development Co.Ltd. Agents antimicrobiens
WO2013114362A1 (fr) 2012-01-30 2013-08-08 Yeda Research And Development Co. Ltd. Protéines de fusion comprenant des modules cohésines de type ii, complexes multienzymatiques comprenant celles-ci et leurs utilisations
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US9864846B2 (en) 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
US9515676B2 (en) 2012-01-31 2016-12-06 Life Technologies Corporation Methods and computer program products for compression of sequencing data
WO2013116774A1 (fr) 2012-02-01 2013-08-08 Gen-Probe Incorporated Sondes oligomériques asymétriques en épingle à cheveu
DE102012201475B4 (de) 2012-02-01 2014-12-18 Gna Biosolutions Gmbh Verfahren zum Vervielfältigen von Nukleinsäuren
EP2809780B1 (fr) 2012-02-01 2018-05-02 Protalix Ltd. Composition liquide inhalable de dnase i
CA2861387A1 (fr) 2012-02-02 2013-08-08 Invenra, Inc. Crible haut debit pour des polypeptides biologiquement actifs
WO2013113748A1 (fr) 2012-02-02 2013-08-08 Primer Design Ltd Procédé pour détecter et génotyper un acide nucléique cible
AU2013214776B2 (en) 2012-02-02 2017-11-09 Board Of Regents, The University Of Texas System Adenoviruses expressing heterologous tumor-associated antigens
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US10184131B2 (en) 2012-02-06 2019-01-22 A.B. Seeds Ltd. Isolated polynucleotides expressing or modulating microRNAs or targets of same, transgenic plants comprising same and uses thereof
GB201202027D0 (en) 2012-02-06 2012-03-21 Sareum Ltd Pharmaceutical compounds
BR112014019331A2 (pt) 2012-02-06 2022-07-12 Inhibrx Inc anticorpos para cd47 e métodos de uso desses
WO2013117705A1 (fr) 2012-02-09 2013-08-15 Var2 Pharmaceuticals Aps Ciblage de glycanes de sulfate de chondroïtine
EP3495817A1 (fr) 2012-02-10 2019-06-12 Raindance Technologies, Inc. Essai de criblage diagnostique moléculaire
US10047345B2 (en) 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
MX362446B (es) 2012-02-14 2019-01-18 Opko Biologics Ltd Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
CN104144695A (zh) 2012-02-15 2014-11-12 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
US10421798B2 (en) 2012-02-15 2019-09-24 Bioverativ Therapeutics Inc. Factor VIII compositions and methods of making and using same
WO2013120553A1 (fr) 2012-02-15 2013-08-22 Novo Nordisk A/S Anticorps qui se lient et bloquent la stimulation d'un récepteur exprimé sur des cellules myéloïdes 1 (trem-1)
AR089993A1 (es) 2012-02-15 2014-10-01 Aileron Therapeutics Inc Macrociclos peptidomimeticos
EP3456742A1 (fr) 2012-02-15 2019-03-20 Novo Nordisk A/S Anticorps qui se lient à la protéine 1 de reconnaissance du peptidoglycane
SI2822577T1 (sl) 2012-02-15 2019-07-31 Bioverativ Therapeutics Inc. Rekombinantni proteini faktorja VIII
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
CN104334196B (zh) 2012-02-16 2018-04-10 Atyr 医药公司 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶
WO2013123125A1 (fr) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assemblage de séquences d'acide nucléique dans des émulsions
CN104321355A (zh) 2012-02-17 2015-01-28 Nvs技术股份有限公司 用于测定应用的聚合物支架
IN2014MN01806A (fr) 2012-02-19 2015-07-03 Protalix Ltd
GB2501611B (en) 2012-02-21 2015-03-04 Cytonics Corp Alpha-2-macroglobulin compositions and therapeutic uses
EP2817627A2 (fr) 2012-02-21 2014-12-31 Oslo Universitetssykehus HF Méthodes et biomarqueurs permettant de dépister et de pronostiquer le cancer du col utérin
WO2013124743A1 (fr) 2012-02-22 2013-08-29 Population Genetics Technologies Ltd. Compositions et procédés pour le réarrangement intramoléculaire d'acide nucléique
EP3401394A1 (fr) 2012-02-22 2018-11-14 Exostem Biotec Ltd Génération de cellules souches neurales
WO2013126807A2 (fr) 2012-02-22 2013-08-29 Life Technologies Corporation Acquisition simultanée de données biométriques et d'acide nucléique
WO2013124817A2 (fr) 2012-02-22 2013-08-29 Brainstem Biotec Ltd. Microarn pour la génération d'astrocytes
EP2817416B1 (fr) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Détection de gènes de toxine dysentérique dans des bactéries
EP3309262B1 (fr) 2012-02-24 2019-09-25 Bio-Rad Laboratories, Inc. Marquage et préparation d'échantillon pour le séquençage
DK2817287T3 (da) 2012-02-24 2019-01-02 Arbutus Biopharma Corp Trialkyl kationisk lipid og metoder til anvendelse deraf
WO2013130512A2 (fr) 2012-02-27 2013-09-06 The University Of North Carolina At Chapel Hill Procédés et utilisations d'étiquettes moléculaires
WO2013130634A1 (fr) * 2012-02-27 2013-09-06 Mayo Foundation For Medical Education And Research Translocations tbl1xr1 et tp63
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
WO2013128454A1 (fr) 2012-03-01 2013-09-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Plantes d'ail stérile mâle, descendance hybride de celles-ci et procédés de génération et d'utilisation de celles-ci
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
MX354465B (es) 2012-03-05 2018-03-06 Seegene Inc Deteccion de variacion del nucleotido en la secuencia de acido nucleico de objetivo por ensayo de desdoblamiento y extension de pto.
JP6302847B2 (ja) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
KR101912982B1 (ko) 2012-03-06 2018-10-29 셀렉트 바이오테라퓨틱스 리미티드 세포자멸사-신호전달 내성 세포를 선택하기 위한 디바이스 및 방법, 그리고 그의 용도
EP2823059A2 (fr) 2012-03-06 2015-01-14 Oslo Universitetssykehus HF Signatures géniques associées à l'efficacité d'une radiothérapie postmastectomie dans le cancer du sein
EP2823706A4 (fr) 2012-03-07 2015-09-23 Kirin Holdings Kk Plante présentant une expression inhibée d'un gène d'enzyme biosynthétique glycoalcaloïde ou une activité modifiée de l'enzyme
CN104411724B (zh) 2012-03-07 2018-08-31 耶达研究及发展有限公司 抑制静止素巯基氧化酶(qsox1)的组合物及其用途
TR201815503T4 (tr) 2012-03-15 2018-11-21 Curna Inc Beyin kaynaklı nörotrofik faktör (bknf) ile ilişkili hastalıkların doğal antisens transkriptinin bknf'ye inhibisyonu ile muamelesi.
GB2501238B (en) 2012-03-16 2018-10-24 Cambridge Entpr Ltd Methods for obtaining liquid from a solid phase
WO2013139861A1 (fr) 2012-03-20 2013-09-26 Luc Montagnier Procédés et compositions pharmaceutiques pour le traitement de troubles du syndrome de l'autisme
UA118173C2 (uk) 2012-03-20 2018-12-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб ідентифікації рослини соняшнику, яка має низький вміст пальмітинової кислоти
WO2013139479A1 (fr) 2012-03-21 2013-09-26 Institut Gustave Roussy (Igr) Nouveaux marqueurs de diagnostic d'une leucémie myélomonocytaire chronique (cmml) spécifique
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013140389A1 (fr) 2012-03-22 2013-09-26 Ramot At Tel-Aviv University Ltd. Peptides multimères plif et utilisations de ceux-ci
US20130276157A1 (en) 2012-03-23 2013-10-17 Genus, Plc Cyb5 and cyp17 mutations for alteration of 16-androstene steroid synthesis and reduced boar taint in pigs
US9688995B2 (en) 2012-03-23 2017-06-27 Kirin Holdings Kabushiki Kaisha Gene encoding enzyme that reduces position 24 of steroid skeleton and plant in which expression level of the gene is lowered
EP2827991B1 (fr) 2012-03-23 2019-05-29 QIAGEN GmbH Appareil de cycle thermique et procédé de chauffage et de refroidissement
WO2013148346A1 (fr) 2012-03-28 2013-10-03 Longhorn Vaccines And Diagnostics, Llc Compositions et procédés pour la collecte et l'isolement d'acides nucléiques à partir de spécimens biologiques
CN104334191A (zh) 2012-03-29 2015-02-04 纽约市哥伦比亚大学托管会 治疗毛发脱落疾病的方法
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
SG10201608234UA (en) 2012-04-02 2016-11-29 Berg Llc Interrogatory cell-based assays and uses thereof
WO2013151647A1 (fr) 2012-04-02 2013-10-10 Life Technologies Corporation Compositions et procédés pour la détection de mycobacterium avium paratuberculosis
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
WO2013152307A1 (fr) 2012-04-05 2013-10-10 The Regents Of The University Of California Panneau d'expression génique pour le pronostic du cancer du sein
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
WO2013155439A1 (fr) 2012-04-13 2013-10-17 Massachusetts Institute Of Technology Calcul et circuits analogiques et à signaux mixtes dans des cellules vivantes
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
EP2839015B1 (fr) 2012-04-18 2020-04-29 Ramot at Tel-Aviv University Ltd. Particules de glycosaminoglycane lipidé pour la libération d'acides nucléiques
EP3461910B1 (fr) 2012-04-19 2020-08-26 Life Technologies Corporation Amplification d'acides nucléiques
AU2013250711A1 (en) 2012-04-19 2014-11-27 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
WO2013158313A1 (fr) 2012-04-19 2013-10-24 Life Technologies Corporation Amplification d'acides nucléiques
EP3524692A1 (fr) 2012-04-20 2019-08-14 T2 Biosystems, Inc. Compositions et procédés de détection d'espèces de candida
CN111876409A (zh) 2012-04-24 2020-11-03 Gen9股份有限公司 在体外克隆中分选核酸和多重制备物的方法
US20130280238A1 (en) 2012-04-24 2013-10-24 Laboratory Corporation Of America Holdings Methods and Systems for Identification of a Protein Binding Site
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
EP2841084B1 (fr) 2012-04-24 2018-05-30 Biokine Therapeutics Ltd. Peptide antagoniste de cxcr4 et son utilisation pour le traitment de tumeurs pulmonaires
AR090558A1 (es) 2012-04-24 2014-11-19 Pioneer Hi Bred Int Evento de maiz dp-004114-3 y metodos para su deteccion
JP6670106B2 (ja) 2012-04-26 2020-03-18 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago ブドウ球菌コアグラーゼ抗原およびその使用方法
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
WO2013160374A1 (fr) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Procédé de raffinage d'huile végétale brute comprenant une hydrolyse enzymatique et un recyclage de gommes
WO2013160372A1 (fr) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Procédé de traitement d'huile végétale comprenant l'ajout de doses successives de chlorophylle ou d'une enzyme de dégradation de dérivé de chlorophylle
EP2844768B1 (fr) 2012-04-30 2019-03-13 Raindance Technologies, Inc. Analyse d'analyte numérique
WO2013166304A1 (fr) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Séquençage d'adn
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2013166303A1 (fr) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Séquençage d'adn
RU2631797C2 (ru) 2012-05-08 2017-09-26 Эдэптив Байотекнолоджиз Корпорейшн Композиции и способы измерения и калибровки систематической ошибки амплификации в мультиплексных пцр-реакциях
CA2872183C (fr) 2012-05-08 2023-09-26 Monsanto Technology Llc Evenement de mais mon 87411
EP2846819B1 (fr) 2012-05-09 2017-05-03 Yeda Research and Development Co. Ltd. Variants de pro-domaine tace en tant qu'inhibiteur de tnf-a et leur utilisation médicale
CN104583239B (zh) 2012-05-10 2018-09-18 生物蛋白有限公司 多特异单克隆抗体
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
NZ701099A (en) 2012-05-11 2017-04-28 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase enzymes and methods of use
US9133490B2 (en) 2012-05-16 2015-09-15 Transgenomic, Inc. Step-up method for COLD-PCR enrichment
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013177206A2 (fr) 2012-05-21 2013-11-28 Fluidigm Corporation Analyse de particules uniques de populations de particules
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB201208926D0 (en) 2012-05-21 2012-07-04 Vela Operations Pte Ltd Extraction control for DNA
EP4148142A1 (fr) 2012-05-21 2023-03-15 The Scripps Research Institute Procédés de préparation d'échantillons
US9844582B2 (en) 2012-05-22 2017-12-19 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
US8865158B2 (en) 2012-05-22 2014-10-21 Ramot At Tel-Aviv University Ltd. Bacteriophages for reducing toxicity of bacteria
CN104334743B (zh) 2012-05-23 2017-05-03 纳幕尔杜邦公司 芸苔属基因组测定
CA2873828A1 (fr) 2012-05-24 2013-11-28 A.B. Seeds Ltd. Arn a double brin nue interferent en agissant sur les molecules cibles dans des graines de plantes
CA2874407A1 (fr) 2012-05-24 2013-11-28 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Procede pour l'identification de l'origine d'un cancer d'origine primaire inconnue par analyse de methylation
WO2013174997A1 (fr) 2012-05-25 2013-11-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de malignités hématologiques réfractaires
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
WO2013183048A1 (fr) 2012-06-03 2013-12-12 Ben-Gurion University Of The Negev Research And Development Authority Peptides de liaison au titane fonctionnalisés et implants revêtus par ceux-ci
JP6290193B2 (ja) 2012-06-04 2018-03-07 オプコ バイオロジクス リミテッド ペグ化oxm変異体
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
HUE032613T2 (en) 2012-06-04 2017-10-30 Diamedica Therapeutics Inc Human tissue kallikrein 1 is glycosylated isoforms
WO2013184754A2 (fr) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Séquençage spatial d'acides nucléiques à l'aide de sondes d'origami d'adn
JP2015520191A (ja) 2012-06-05 2015-07-16 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ncamペプチド模倣体を用いた精神障害またはその症状を治療するための方法
US9730941B2 (en) 2012-06-07 2017-08-15 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of Pin1
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
US9850192B2 (en) 2012-06-08 2017-12-26 Cj Cheiljedang Corporation Renewable acrylic acid production and products made therefrom
ES2909509T3 (es) 2012-06-08 2022-05-06 Danisco Us Inc Variante de alfa-amilasas con mayor actividad en polímeros de almidón
WO2013185114A2 (fr) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Facteurs de coagulation chimériques
EP3643793A1 (fr) 2012-06-14 2020-04-29 Life Technologies Corporation Nouvelles compositions, nouveaux procédés et kits pour la réaction en chaîne de polymérase en (pcr)
US9085761B1 (en) 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
US9347105B2 (en) 2012-06-15 2016-05-24 Pioneer Hi Bred International Inc Genetic loci associated with resistance of soybean to cyst nematode and methods of use
JP6351582B2 (ja) 2012-06-19 2018-07-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company アシルCoA:リゾホスファチジルコリンアシルトランスフェラーゼおよびリン脂質:ジアシルグリセロールアシルトランスフェラーゼの同時発現による多価不飽和脂肪酸の産生の改善
WO2013192292A1 (fr) 2012-06-21 2013-12-27 Justin Lamb Analyse de séquence d'acide nucléique spécifique d'un locus multiplexe massivement parallèle
CA2877533C (fr) 2012-06-22 2022-08-16 The Trustees Of Dartmouth College Nouveaux produits de recombinaison vista-ig et leur utilisation dans le traitement des troubles autoimmuns, allergiques et inflammatoires
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2877823A1 (fr) 2012-06-25 2014-01-03 Gen9, Inc. Procedes d'assemblage d'acides nucleiques et de sequencage a haut debit
WO2014005076A2 (fr) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Procédés et biomarqueurs pour la détection de troubles rénaux
US20140005061A1 (en) 2012-06-29 2014-01-02 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
EP2867377B1 (fr) 2012-07-02 2019-08-21 The Translational Genomics Research Institute Amorces, dosages et méthodes de détection d'un sous-type d'e. coli
WO2014006621A1 (fr) 2012-07-03 2014-01-09 Nanospun Technologies Ltd. Procédés et dispositifs pour l'adsorption et la biodégradation de pétrole
WO2014008475A2 (fr) 2012-07-05 2014-01-09 The Ohio State University Compositions et procédés associés à des vaccins viraux
EP2870250B2 (fr) 2012-07-06 2022-06-29 Bioverativ Therapeutics Inc. Lignée cellulaire exprimant des polypeptides de facteur viii à une seule chaîne et ses utilisations
CN110054699A (zh) 2012-07-11 2019-07-26 比奥贝拉蒂治疗公司 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
CN104619863A (zh) 2012-07-13 2015-05-13 生命技术公司 采用一组snp的人身份识别
AU2013290102B2 (en) 2012-07-13 2018-11-15 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014014899A1 (fr) 2012-07-16 2014-01-23 Yale University Compositions et méthodes permettant de détecter, traiter et prévenir des maladies et affections
EP2687294A1 (fr) 2012-07-18 2014-01-22 Qiagen Instruments AG Rotor pour cycleur thermique et cycleur thermique
EP3354750A1 (fr) 2012-07-18 2018-08-01 Siemens Healthcare Diagnostics Inc. Kit de normalisation d'échantillons biologiques
MX2015000789A (es) 2012-07-19 2015-05-07 Zoetis Llc Composiciones de virus de la gripe bovina.
KR101743846B1 (ko) 2012-07-19 2017-06-05 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산을 이용하여 정보를 저장하는 방법
WO2014015217A1 (fr) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarqueurs pour patients infectés par le hcv
WO2014015273A1 (fr) 2012-07-20 2014-01-23 Asuragen, Inc. Genotypage complet du fmr1
WO2014015328A1 (fr) 2012-07-20 2014-01-23 President And Fellows Of Harvard College Dosages biologiques de contrôle qualité à base de cellules pour des produits nutraceutiques et médicinaux
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2014018375A1 (fr) 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 et ses utilisations dans des méthodes thérapeutiques et diagnostiques
JP6575950B2 (ja) 2012-07-24 2019-09-18 ファーマサイクリックス エルエルシー Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
ES2730377T3 (es) 2012-07-29 2019-11-11 Yeda Res & Dev Uso de la ruta reductora de la glicina para generar microorganismos formatótrofos y autótrofos
CN104684558A (zh) 2012-07-31 2015-06-03 耶达研究及发展有限公司 诊断和治疗运动神经元疾病的方法
CN104919054A (zh) 2012-07-31 2015-09-16 胡安·卡洛斯·海梅 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法
CA3140358A1 (en) 2012-07-31 2014-02-06 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
EP2879710B1 (fr) 2012-08-03 2019-11-13 Dana-Farber Cancer Institute, Inc. Indications médicales d'agents modulant l'activation des cellules immunitaires et méthodes de criblage
EP2880151B1 (fr) 2012-08-06 2020-06-03 Brainstorm Cell Therapeutics Ltd. Procédés de génération de cellules souches mésechymateuses qui sécrètent des facteurs neurotrophiques
WO2014026053A1 (fr) 2012-08-09 2014-02-13 The Regents Of The University Of California Vecteurs cd25 anti-vih à combinaison pré-sélective, vecteurs de ciblage et procédés d'utilisation
US9139835B2 (en) 2012-08-10 2015-09-22 University Of Iowa Research Foundation Nucleic acid aptamers
WO2014025398A1 (fr) 2012-08-10 2014-02-13 Streck, Inc. Système optique en temps réel pour réaction en chaîne par polymérase
CA2882292C (fr) 2012-08-13 2023-10-17 The Rockefeller University Traitement et diagnostic du melanome
CA2881627A1 (fr) 2012-08-16 2014-02-20 Genomedx Biosciences Inc. Diagnostic du cancer au moyen de biomarqueurs
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
CA2881407A1 (fr) 2012-08-22 2014-02-27 Butamax Advanced Biofuels Llc Production de produits de fermentation
WO2014031178A1 (fr) 2012-08-24 2014-02-27 Etubics Corporation Vecteur adénoviral à réplication déficiente, utile en vaccination
AU2013308647B2 (en) 2012-08-30 2018-10-18 Gen-Probe Incorporated Multiphase nucleic acid amplification
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
US20140068814A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
US9937205B2 (en) 2012-09-04 2018-04-10 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
CN104755632B (zh) 2012-09-06 2017-10-03 生命技术公司 多重y‑str分析
US9689042B2 (en) 2012-09-07 2017-06-27 The Regents Of The University Of California Use of glycolytic pathways for inhibiting or measuring oncogenic signaling
CN105246507B (zh) 2012-09-07 2019-01-25 达特茅斯大学理事会 用于诊断和治疗癌症的vista调节剂
EP3257952B1 (fr) 2012-09-11 2020-02-12 Life Technologies Corporation Amplification d'acides nucléiques
WO2014043143A1 (fr) 2012-09-11 2014-03-20 Life Technologies Corporation Amplification d'acides nucléiques
EP2895608B1 (fr) 2012-09-12 2018-12-05 Quark Pharmaceuticals, Inc. Molécules d'oligonucléotide à double brin p53 et procédés d'utilisation correspondants
WO2014041544A1 (fr) 2012-09-12 2014-03-20 Ramot At Tel-Aviv University Ltd. Immunoparticules et procédés pour les produire et les utiliser
US9611473B2 (en) 2012-09-12 2017-04-04 Quark Pharmaceuticals, Inc. Double-stranded nucleic acid compounds
ES2872349T3 (es) 2012-09-12 2021-11-02 Quark Pharmaceuticals Inc Moléculas de oligonucleótidos bicatenarios para DDIT4 y métodos de uso de las mismas
GB201216387D0 (en) 2012-09-13 2012-10-31 Ge Healthcare Uk Ltd Solid matrix for one step nucleic acid amplification
EP2708605A1 (fr) 2012-09-17 2014-03-19 Institut Gustave Roussy (IGR) ANKRD26 en tant que marqueur pour le diagnostic de thrombocytopenias
WO2014045126A2 (fr) 2012-09-18 2014-03-27 Uti Limited Partnership Traitement de la douleur par inhibition de la déubiquitinase usp5
WO2014045254A2 (fr) 2012-09-23 2014-03-27 Erasmus University Medical Center Rotterdam Lignée c de coronavirus bêta humains et identification de la peptidase dipeptidylique n-terminale en tant que récepteur viral
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
CN105102616A (zh) 2012-09-26 2015-11-25 布特马斯先进生物燃料有限责任公司 具有酮醇酸还原异构酶活性的多肽
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
CN104822844B (zh) 2012-10-01 2019-05-07 米伦纽姆医药公司 预测对抑制剂的反应的生物标记物和方法以及其用途
EP3640343A1 (fr) 2012-10-01 2020-04-22 Adaptive Biotechnologies Corporation Évaluation de l'immunocompétence par la diversité adaptative du récepteur immunitaire et la caractérisation de la clonalité
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
JP2015532294A (ja) 2012-10-03 2015-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル インフルエンザ後の細菌重複感染の予防的処置のための方法および薬学的組成物
CA2887094C (fr) 2012-10-04 2021-09-07 Sequenom, Inc. Procedes et processus d'evaluation non invasive de variations genetiques
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
WO2014055746A1 (fr) 2012-10-04 2014-04-10 The Board Of Trustees Of The Leland Stanford Junior University Procédés et réactifs permettant la détection, la quantification et la sérotypie du virus de la dengue
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2906954B1 (fr) 2012-10-09 2018-04-11 Ramot at Tel-Aviv University Ltd. Procédés et trousses utilisant la mortaline soluble dans le sang pour prédire un pronostic de cancer
EP2906589A1 (fr) 2012-10-10 2015-08-19 INSERM - Institut National de la Santé et de la Recherche Médicale Procédés et compositions pharmaceutiques pour le traitement de tumeurs stromales gastro-intestinales
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
ES2747230T3 (es) 2012-10-10 2020-03-10 Cj Cheiljedang Corp Método de elaboración de copolímeros de polihidroxialcanoato (3HB-co-4HB)
GB201218195D0 (en) 2012-10-10 2012-11-21 Istituto Zooprofilattico Sperimentale Delle Venezie Composition
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
CN117586986A (zh) 2012-10-12 2024-02-23 丹尼斯科美国公司 包含脂解酶变体的组合物和方法
CN104704118A (zh) 2012-10-15 2015-06-10 诺和诺德保健Ag(股份有限公司) 凝血因子vii多肽
US9133510B2 (en) 2012-10-15 2015-09-15 Life Technologies Corporation Compositions, methods, systems and kits for target nucleic acid enrichment
WO2014060483A1 (fr) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Procédés et produit d'optimisation de la détection localisée ou spatiale de l'expression génique dans un échantillon de tissu
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
EP2722399A1 (fr) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Procédé de prévention de produits à poids moléculaire élevé lors de l'amplification
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
EP2722397B1 (fr) 2012-10-18 2017-12-13 F. Hoffmann-La Roche AG Analyse de sonde double pour la détection de populations d'amplicons hétérogènes
EP2722398B1 (fr) 2012-10-18 2017-07-12 F. Hoffmann-La Roche AG Analyse de sonde double pour la détection du VHC
WO2014063097A1 (fr) 2012-10-19 2014-04-24 Danisco Us Inc. Stabilisation de membranes biomimétiques
US9395369B2 (en) 2012-10-19 2016-07-19 Regents Of The University Of Minnesota Guinea pig cytomegalovirus (CIDMTR strain)
AU2013336237A1 (en) 2012-10-22 2015-06-11 Sabag-Rfa Ltd A system for delivering therapeutic agents into living cells and cells nuclei
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
CA2887825A1 (fr) 2012-10-23 2014-05-01 The Board Of Regents Of The University Of Texas System Anticorps avec des domaines fc d'igg modifies
EP3584259A1 (fr) 2012-10-24 2019-12-25 Yeda Research and Development Co., Ltd. Combinaisons d'anticorps ciblant les récepteurs du facteur de croissance épidermique pour traiter le cancer
EP2912181B1 (fr) 2012-10-29 2017-11-29 Yeda Research and Development Co., Ltd. Aptamères, aptamères multimères et leurs utilisations
EP2728013A1 (fr) 2012-10-31 2014-05-07 Universitätsspital Basel Procédé d'amplification simultanée de plusieurs séquences cibles différentes d'acide nucléique
EP2728015A1 (fr) 2012-10-31 2014-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé pour le diagnostic du syndrome de Sézary
EP2914344B1 (fr) 2012-10-31 2020-01-15 The Rockefeller University Traitement du cancer du côlon métastatique
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
ES2749463T3 (es) 2012-11-02 2020-03-20 Life Technologies Corp Captura, detección y cuantificación de ARN pequeño
US9809863B2 (en) 2012-11-02 2017-11-07 Elanco Tiergesundheit Ag Flavivirus associated with Theiler's disease
JP6858487B2 (ja) 2012-11-05 2021-04-14 ダニスコ・ユーエス・インク サーモリシンプロテアーゼ変異体を含む組成物及び方法
EP3800256A1 (fr) 2012-11-06 2021-04-07 InteRNA Technologies B.V. Combinaison à utiliser dans le cadre d'un usage thérapeutique contre des maladies ou des affections associées au mélanome ou à l'activation de la voie de signalisation braf
WO2014074755A1 (fr) 2012-11-07 2014-05-15 Yale University Estimation du risque d'une déficience de la lecture et du langage
CA2890441A1 (fr) 2012-11-07 2014-05-15 Good Start Genetics, Inc. Procedes et systemes permettant d'identifier une contamination dans des echantillons
WO2014074863A2 (fr) 2012-11-08 2014-05-15 Wafergen, Inc. Extraction de liquide retenu à partir de puits
WO2014072416A1 (fr) 2012-11-08 2014-05-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de métastases osseuses
RU2015115956A (ru) 2012-11-09 2017-01-10 Пфайзер Инк. Антитела, специфичные в отношении фактора роста тромбоцитов в, и их композиции и применения
US20160369321A1 (en) 2012-11-14 2016-12-22 Olink Ab RCA Reporter Probes and Their Use in Detecting Nucleic Acid Molecules
MX363326B (es) 2012-11-20 2019-03-20 Opko Biologics Ltd Metodo para incrementar el volumen hidrodinamico de polipeptidos mediante la union a peptidos carboxi-terminales de gonadotrofina.
US9710596B2 (en) 2012-11-21 2017-07-18 Exact Sciences Corporation Methods for quantifying nucleic acid variations
US10260103B2 (en) 2012-11-27 2019-04-16 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
ME02925B (fr) 2012-11-28 2018-04-20 Merck Sharp & Dohme Compositions et procédés pour traiter le cancer
WO2015079413A2 (fr) 2013-11-28 2015-06-04 Yeda Research And Development Co. Ltd. Inhibiteurs de synaptojanine-2 et leurs utilisations
BR112015002626A2 (pt) 2012-11-29 2017-09-26 Yeda Res & Dev métodos para prevenção de metástases tumorais, tratamento e prognostico do câncer e identificação dos agentes que são inibidores da metástase putativa
CA3137404A1 (en) 2012-11-30 2014-06-05 Accelerated Biosciences Corp. Pancreatic progenitor cells expressing betatrophin and insulin
EP2738263A1 (fr) 2012-11-30 2014-06-04 Fundacion para la Investigacion del Hospital Clinico de la Comunidad Valenciana Procédés d'analyse de réarrangements d'ADN
US9618428B2 (en) 2012-11-30 2017-04-11 Ge Healthcare Uk Limited Biometric device and means for electronic storage and retrieval of biometric data
CN103114131B (zh) 2012-11-30 2018-10-02 珠海市坤元农业科技有限公司 一种引物中部序列干扰pcr技术
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
US10125369B2 (en) 2012-12-05 2018-11-13 Alnylam Pharmaceuticals, Inc. PCSK9 iRNA compositions and methods of use thereof
EP2929044B1 (fr) 2012-12-07 2019-02-06 Invitae Corporation Procédés de détection d'acide nucléique multiplexe
EP3524691A1 (fr) 2012-12-07 2019-08-14 SuppreMol GmbH Stratification et traitement de patients du purpura thrombocytopénique idiopathique
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
KR101600902B1 (ko) * 2012-12-11 2016-03-10 주식회사 셀레믹스 코돈 조합화 및 변이유발을 이용한 유전자 라이브러리의 합성 방법
CA2894710A1 (fr) 2012-12-13 2014-06-19 Massachusetts Institute Of Technology Logique et systemes de memoire bases sur la recombinase
CN114176586A (zh) 2012-12-14 2022-03-15 明德拉公司 用于检测和获取生物标志物的方法和装置
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
CN105121624A (zh) 2012-12-19 2015-12-02 沃德金有限公司 制备脂肪二羧酸的生物学方法
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
CN105189731A (zh) 2012-12-19 2015-12-23 沃德金有限公司 制备脂肪二羧酸的生物学方法
US9939443B2 (en) 2012-12-19 2018-04-10 Caris Life Sciences Switzerland Holdings Gmbh Compositions and methods for aptamer screening
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
US20150346097A1 (en) 2012-12-21 2015-12-03 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
EP2934751B1 (fr) 2012-12-21 2019-05-29 Micronics, Inc. Films à faible élasticité pour utilisation micro-fluidique
WO2014106107A2 (fr) 2012-12-28 2014-07-03 Butamax (Tm) Advanced Biofuels Llc Variants de dhad pour la production de butanol
NZ709828A (en) 2012-12-28 2019-07-26 Prec Biologics Inc Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
WO2014105840A1 (fr) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Production d'alcools par fermentation
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
UY35252A (es) 2013-01-01 2014-07-31 Seeds Ltd Ab MÉTODOS PARA INTRODUCIR dsRNA EN SEMILLAS DE PLANTAS PARA MODULAR LA EXPRESIÓN GENÉTICA
US10253329B2 (en) 2013-01-04 2019-04-09 Board Of Trustees Of Michigan State University Sources of aphid resistance in soybean plants
WO2014108854A1 (fr) 2013-01-09 2014-07-17 Fusimab Ltd. Anticorps anti-hgf et anti-ang2 monospécifiques, et anticorps anti-hgf/anti-ang2 bispécifiques
WO2014108850A2 (fr) 2013-01-09 2014-07-17 Yeda Research And Development Co. Ltd. Analyse de transcriptome à haut débit
EP2946345B1 (fr) 2013-01-17 2024-04-03 Personalis, Inc. Procédés et systèmes d'analyse génétique
EP2946207B1 (fr) 2013-01-17 2018-05-16 Novellusdx Ltd. Procédés et systèmes pour identifier des mutations conductrices spécifiques à un patient
TW201514310A (zh) 2013-01-21 2015-04-16 Abbvie Inc 發炎性疾病之抗-tnf與抗-il17組合療法生物標記
WO2014116721A1 (fr) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Vecteur geminiviral pour l'expression du rituximab
RU2644769C2 (ru) 2013-01-23 2018-02-14 Астразенека Аб Химические соединения
CA2897474A1 (fr) 2013-01-24 2014-07-31 California Institute Of Technology Caracterisation a base de chromophore et procedes de detection
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150361447A1 (en) 2013-01-25 2015-12-17 Pioneer Hi-Breed International, Inc. Maize event dp-032218-9 and methods for detection thereof
CA2899659C (fr) 2013-01-28 2023-09-05 Kansas State University Research Foundation Glycoproteines gn et gc du virus de la fievre de la vallee du rift, et leur utilisation
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
EP2950808B1 (fr) 2013-02-04 2019-08-21 Ramot at Tel-Aviv University Ltd. Génération de lignées cellulaires spécifiques d'une tumeur cytotoxiques et leurs utilisations
WO2014122199A1 (fr) 2013-02-06 2014-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter la pseudo-obstruction intestinale chronique
US8956821B2 (en) 2013-02-06 2015-02-17 Medical Service Consultation International, Llc Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins
EP2953643B1 (fr) 2013-02-06 2023-02-22 Inhibrx, Inc. Anticorps cd47 n'induisant ni l'appauvrissement en globules rouges ni l'appauvrissement en plaquettes et methodes d'utilisation de ceux-ci
JP6673698B2 (ja) 2013-02-15 2020-03-25 エクソサム ダイアグノスティクス,インコーポレイティド 新規のegfr変異体
LT2956477T (lt) 2013-02-15 2021-02-10 Bioverativ Therapeutics Inc. Optimizuotas faktoriaus viii genas
WO2014128127A1 (fr) 2013-02-19 2014-08-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter le cancer de la prostate
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D
ES2900102T3 (es) 2013-02-20 2022-03-15 Univ Emory Composiciones para la secuenciación de ácidos nucleicos en mezclas
EP2959012B1 (fr) 2013-02-21 2018-02-14 Qualicon Diagnostics LLC Séquences et leur utilisation en vue de la détection et de la caractérisation du sérotype o157:h7 d'e. coli
EP2958994B1 (fr) 2013-02-21 2019-05-29 Turnstone Limited Partnership Composition de vaccin
MX2015010927A (es) 2013-02-22 2015-10-29 Zoetis Services Llc Administracion in ovo de factores de crecimiento para mejorar el rendimiento de aves de corral.
AU2014218807A1 (en) 2013-02-22 2015-09-03 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
EP2770065B1 (fr) 2013-02-25 2017-12-13 Seegene, Inc. Détection de variations de nucléotides sur une séquence d'acide nucléique cible
WO2014134202A1 (fr) 2013-02-26 2014-09-04 Triact Therapeutics, Inc. Cancérothérapie
WO2014134179A1 (fr) 2013-02-28 2014-09-04 The Board Of Regents Of The University Of Texas System Procédés pour classer un cancer comme sensible aux thérapies dirigées par tmepai et pour traiter ces cancers
AU2014223824B2 (en) 2013-02-28 2020-02-27 Albert Einstein College Of Medicine, Inc. Tuberculosis biomarkers and uses thereof
US9783817B2 (en) 2013-03-04 2017-10-10 Arkansas State University Methods of expressing and detecting activity of expansin in plant cells
US20160017302A1 (en) 2013-03-05 2016-01-21 Baylor College Of Medicine Heparanase expression in human t lymphocytes
CA2904230A1 (fr) 2013-03-05 2014-09-12 Baylor College Of Medicine Cellules d'engagement pour immunotherapie
WO2014136117A1 (fr) 2013-03-06 2014-09-12 Protalix Ltd. Utilisation de cellules végétales exprimant un inhibiteur du polypeptide tnf alpha en thérapie
US20160017021A1 (en) 2013-03-06 2016-01-21 Protalix Ltd. TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME
CN105339498A (zh) 2013-03-07 2016-02-17 贝勒医学院 癌症中靶向cd138
WO2014135984A2 (fr) 2013-03-07 2014-09-12 Recopharma Ab Dispositif revêtu par une protéine de fusion mucine glycosylée-immunoglobuline
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
KR102092435B1 (ko) 2013-03-08 2020-03-24 예일 유니버시티 피부색소침착 감소용 조성물 및 방법
US11585814B2 (en) 2013-03-09 2023-02-21 Immunis.Ai, Inc. Methods of detecting prostate cancer
EP2964764A1 (fr) 2013-03-09 2016-01-13 Baylor College Of Medicine Traitement par lymphocytes t à ciblage vasculaire
US10494675B2 (en) 2013-03-09 2019-12-03 Cell Mdx, Llc Methods of detecting cancer
EP3640347A3 (fr) 2013-03-12 2020-07-29 Life Technologies Corporation Procédés et matériaux de génotypage fondés sur des indicateurs universels
WO2014168711A1 (fr) 2013-03-13 2014-10-16 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
CN105263329B (zh) 2013-03-13 2020-09-18 孟山都技术公司 用于杂草控制的方法和组合物
EP2971115B1 (fr) 2013-03-13 2022-07-27 Seegene, Inc. Quantification d'un acide nucléique cible à l'aide d'analyse du pic de fusion
CA2906003C (fr) 2013-03-13 2021-07-06 Bioasis Technologies Inc. Fragments de p97 et leurs utilisations
CA2905049A1 (fr) 2013-03-13 2014-10-02 Trustees Of Boston University Commande personnalisable de degradation proteique dans des systemes bacteriens synthetiques et endogenes
AR095232A1 (es) 2013-03-13 2015-09-30 Monsanto Technology Llc Métodos y composiciones para el control de malezas
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的系统和方法
JP2016511010A (ja) 2013-03-14 2016-04-14 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company ブタノール製造用のグリセロール3−ホスフェートデヒドロゲナーゼ
EA201591707A1 (ru) 2013-03-14 2016-03-31 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ иРНК КОМПОНЕНТА КОМПЛЕМЕНТА C5 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US9701999B2 (en) 2013-03-14 2017-07-11 Abbott Molecular, Inc. Multiplex methylation-specific amplification systems and methods
CN105378109B (zh) 2013-03-14 2019-06-14 雅培分子公司 使用尿嘧啶-dna-n-糖基化酶使错误最小化
WO2014140167A1 (fr) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Enzymes de décomposition de la paroi cellulaire issues de malbranchea cinnamomea et leurs utilisations
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US20140287946A1 (en) 2013-03-14 2014-09-25 Ibis Biosciences, Inc. Nucleic acid control panels
ES2947873T3 (es) 2013-03-14 2023-08-23 Mayo Found Medical Education & Res Detección de neoplasias
CN105189527A (zh) 2013-03-14 2015-12-23 科德克希思公司 低-磷酸盐可阻遏的启动子
WO2014140165A1 (fr) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Enzymes de déconstruction de la paroi cellulaire de paecilomyces byssochlamydoides et utilisations de celles-ci
US9255290B2 (en) 2013-03-14 2016-02-09 The Regents Of The University Of California Methods and devices for non-therman polymerase chain reaction
EP2971139A4 (fr) 2013-03-15 2016-12-07 Abbott Molecular Inc Systèmes et procédés pour la détection de changements de nombre de copie de génome
MX365323B (es) 2013-03-15 2019-05-29 Theranos Ip Co Llc Amplificación de ácidos nucléicos.
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US20140302504A1 (en) 2013-03-15 2014-10-09 Theranos, Inc. Nucleic Acid Amplification
CA2899089C (fr) 2013-03-15 2021-10-26 Biogen Ma Inc. Preparations contenant un polypeptide du facteur ix
BR112015023703A2 (pt) 2013-03-15 2017-07-18 Pioneer Hi Bred Int modulação de expressão de deaminase de acc
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
BR112015022167A2 (pt) 2013-03-15 2017-07-18 Theranos Inc dispositivos, sistemas e métodos para preparação de amostras
EP3360958B1 (fr) 2013-03-15 2021-12-22 Labrador Diagnostics LLC Ligase à extrémité franche thermostable et procédés d'utilisation
WO2014145291A1 (fr) 2013-03-15 2014-09-18 Theranos, Inc. Amplification d'acide nucléique
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening
WO2014144583A2 (fr) 2013-03-15 2014-09-18 Northwestern University Procédés pour la synthèse de protéine sans cellule
US10612061B2 (en) 2013-03-15 2020-04-07 Lallemand Hungary Liquidity Management Llc Expression of beta-glucosidases for hydrolysis of lignocellulose and associated oligomers
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
EP2971112A2 (fr) 2013-03-15 2016-01-20 TrovaGene, Inc. Détection d'acides nucléiques dans l'urine
EP3404116B1 (fr) 2013-03-15 2022-10-19 The University of Chicago Procédés et compositions liés à l'activité des lymphocytes t
EP2968551B1 (fr) 2013-03-15 2021-05-05 The Trustees of Columbia University in the City of New York Protéines de fusion et procédés correspondants
WO2014150910A1 (fr) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Séquences d'adn pour estimer la contamination dans le séquençage d'adn
ES2671745T3 (es) 2013-03-15 2018-06-08 Becton, Dickinson And Company Detección de Neisseria gonorrhoeae
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
EP2968416A4 (fr) 2013-03-15 2016-08-17 Fate Therapeutics Inc Essai d'activité biologique de cellules pour un potentiel thérapeutique
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
US9828629B2 (en) 2013-03-15 2017-11-28 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
JP6591394B2 (ja) 2013-03-15 2019-10-16 サイバス ユーエス エルエルシー オリゴヌクレオチド仲介型遺伝子修復を使用した標的遺伝子修飾の効率を高めるための方法および組成物
CN105142789A (zh) 2013-03-15 2015-12-09 纳诺拜希姆公司 用于移动设备分析核酸和蛋白质的系统和方法
US9708658B2 (en) 2013-03-19 2017-07-18 New England Biolabs, Inc. Enrichment of target sequences
WO2014147622A1 (fr) 2013-03-21 2014-09-25 Collplant Ltd. Compositions comprenant du collagène et prp pour la régénération tissulaire
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
US20160082071A1 (en) 2013-03-24 2016-03-24 Biokine Therapeutics Ltd. Methods of treating myeloid leukemia
EP2978842B1 (fr) 2013-03-26 2018-05-02 Matis ohf. Enzymes de ramification de glucane et leurs procédés d'utilisation
CN105324492A (zh) 2013-03-26 2016-02-10 健能泰格技术公司 用于dna和rna检测的双探针:反探针组合物
WO2015060511A1 (fr) 2013-10-22 2015-04-30 주식회사 바이오이즈 Marqueur pour générer des informations de liaison sur des biomolécules et des acides nucléiques, procédé de préparation afférent, et procédé et appareil d'analyse de biomolécule les utilisant
EP2981921B1 (fr) 2013-04-03 2023-01-18 Sequenom, Inc. Procédés et systèmes d'évaluation non invasive de variations génétiques
WO2014166836A1 (fr) 2013-04-05 2014-10-16 Novo Nordisk A/S Formulation de composés d'hormone de croissance
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
EP2986627B1 (fr) 2013-04-18 2019-04-10 Carmel Haifa University Economic Corporation Ltd. Inhibiteurs du récepteur eph-a et utilisations de ces derniers
WO2014172288A2 (fr) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Analyse d'analyte numérique
WO2014174511A1 (fr) 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents de régulation à la baisse de l'activité et/ou de la quantité de bcl-xl et/ou bcl-w
WO2014173859A2 (fr) 2013-04-22 2014-10-30 Institut National De La Recherche Agronomique Antagonistes de par4 pour l'utilisation dans le traitement ou la prévention d'infections par le virus de la grippe de type a
US10920192B2 (en) 2013-04-23 2021-02-16 Yeda Research And Development Co. Ltd. Isolated naive pluripotent stem cells and methods of generating same
SG11201508791WA (en) 2013-04-23 2015-11-27 Thermo Fisher Scientific Oy Melt curve analysis
ES2671002T3 (es) 2013-04-25 2018-06-04 Yeda Research And Development Co., Ltd. Uso de péptidos inhibidores para el tratamiento de enfermedades inflamatorias
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
CN105408495B (zh) 2013-04-26 2019-01-08 基纽拜奥股份有限公司 通过茎环结构阻断3’dna末端的聚合酶延伸的方法
EP2992331A4 (fr) 2013-04-30 2017-03-29 Université de Montréal Nouveaux biomarqueurs pour la leucémie myéloïde aiguë
ES2727898T3 (es) 2013-05-02 2019-10-21 Univ Michigan Regents Amlexanox deuterado con estabilidad metabólica mejorada
AU2014262710B2 (en) 2013-05-07 2019-09-12 Perkinelmer Health Sciences, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014182847A1 (fr) 2013-05-07 2014-11-13 Micronics, Inc. Dispositif pour la préparation et l'analyse d'acides nucléiques
CN105189560A (zh) 2013-05-07 2015-12-23 瑞纳神经科学公司 抗胰高血糖素受体抗体和其使用方法
WO2014182844A1 (fr) 2013-05-07 2014-11-13 Micronics, Inc. Dispositifs microfluidiques et méthodes de séparation du sérum et de compatibilité croisée du sang
GB201308313D0 (en) 2013-05-09 2013-06-19 Medical Res Council Assay Method
EP2999717B1 (fr) 2013-05-21 2018-08-08 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Traitement des pathologies impliquant des mastocytes
WO2014189085A1 (fr) 2013-05-21 2014-11-27 ユニバーサル・バイオ・リサーチ株式会社 Dispositif et procédé de prétraitement de séquenceur
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer
CA2912834A1 (fr) 2013-05-22 2014-11-27 Alnylam Pharmaceuticals, Inc. Compositions de tmprss6 et methodes d'utilisation de ces compositions
UY35582A (es) 2013-05-22 2014-10-31 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi DE SERPINA1 Y SUS MÉTODOS DE USO
EP2999800B1 (fr) 2013-05-22 2019-09-25 Telomere Diagnostics Inc. Mesures de l'abondance de télomères courts
KR102540202B1 (ko) 2013-05-24 2023-06-02 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
BR112015029815B1 (pt) 2013-05-27 2020-06-30 Rakuto Bio Technologies Ltd Composição cosmética para clarear uma pele e/ou cabelo de um indiví$#205;duo e conjunto para clarear uma pele e/ou cabelo de um indivíduo
EP3004090B1 (fr) 2013-05-28 2017-10-25 Astrazeneca AB Composés chimiques
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
EP3293275B1 (fr) 2013-06-06 2021-08-04 Dana-Farber Cancer Institute, Inc. Compositions et procedes d'identification,d'evaluation, de prevention et de traitement du cancer en utilisant des isoformes pd-l1
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
WO2014201155A1 (fr) 2013-06-11 2014-12-18 Courtagen Life Sciences, Inc. Méthodes et nécessaires permettant de traiter et de classer des individus risquant de souffrir ou souffrant d'un changement de fonction de trap1
WO2014199364A1 (fr) 2013-06-13 2014-12-18 Bnai Zion Medical Center Sémphorine 3a pour le traitement et le pronostic du lupus érythémateux systémique
ES2775213T3 (es) 2013-06-13 2020-07-24 Ariosa Diagnostics Inc Análisis estadístico para la determinación no invasiva de aneuploidías de los cromosomas sexuales
AU2014278155B2 (en) 2013-06-14 2018-05-17 Monsanto Technology Llc Soybean transgenic event MON87751 and methods for detection and use thereof
US9428748B2 (en) 2013-06-17 2016-08-30 Hong Gao Method of expanding hematopoietic stem cells
JP6159161B2 (ja) 2013-06-18 2017-07-05 キリン株式会社 ステロイド骨格の16位を酸化する酵素をコードする遺伝子および該遺伝子の発現が低下した植物体
ES2728307T3 (es) 2013-06-21 2019-10-23 Danisco Us Inc Composiciones y métodos para la transformación clostridial
CA2915628C (fr) 2013-06-21 2020-04-21 Sequenom, Inc. Procedes et processus d'evaluation non invasive de variations genetiques
EP3013380B1 (fr) 2013-06-24 2022-11-23 Ramot at Tel-Aviv University Ltd. Échafaudage à base d'épiploon et système d'administration
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
EP3014251A1 (fr) 2013-06-28 2016-05-04 Streck Inc. Dispositifs pour réaction en chaîne de polymérase en temps réel
MX2015016567A (es) 2013-06-28 2016-03-31 Biogen Ma Inc Enlazador escindible por trombina con xten y usos del mismo.
WO2015002939A1 (fr) 2013-07-01 2015-01-08 Massachusetts Institute Of Technology Fonctionnalisation de bactéries endogènes
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015000014A1 (fr) 2013-07-01 2015-01-08 Newsouth Innovations Pty Limited Diagnostic et traitement de maladies autoimmunes
WO2015001082A1 (fr) 2013-07-05 2015-01-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouveaux transcrits d'épissage alternatif pour la chaîne alpha associée au cmh de classe i (mica) et leurs utilisations
EP2821502A1 (fr) 2013-07-05 2015-01-07 Centre National de la Recherche Scientifique (CNRS) Procédé d'évaluation de compétence du développement d'un ovocyte
DE102013213279B4 (de) 2013-07-06 2024-03-28 Ist Innuscreen Gmbh Universelles Verfahren zur Detektion von diversen Analyten in Form von Nukleinsäuresequenzen
JP6443811B2 (ja) 2013-07-10 2018-12-26 エフストック リミテッド ライアビリティ カンパニー Mrap2ノックアウト
JP6203394B2 (ja) 2013-07-15 2017-09-27 ザ クリーブランド クリニック ファウンデーションThe Cleveland ClinicFoundation ステロイド依存性疾患における3β−ヒドロキシステロイドデヒドロゲナーゼ
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
PL3030663T3 (pl) 2013-07-19 2020-04-30 Monsanto Technology Llc Kompozycje i sposoby kontroli leptinotarsa
US11981942B2 (en) 2013-07-23 2024-05-14 International N&H Denmark Aps Xylanases for solubilizing arabinoxylan-containing material
US20160151284A1 (en) 2013-07-23 2016-06-02 Protiva Biotherapeutics, Inc. Compositions and methods for delivering messenger rna
US9828624B2 (en) 2013-07-24 2017-11-28 Boston Heart Diagnostics Corporation Driving patient compliance with therapy
WO2015015489A1 (fr) 2013-07-30 2015-02-05 Biolinerx Ltd. Anticorps convenant au traitement du diabète et de maladies autoimmunes
CA2919477A1 (fr) 2013-07-31 2015-02-05 Dana-Farber Cancer Institute, Inc. Compositions et methodes de modulation de thermogenese a l'aide de molecules liees a la pth et liees au egf
US9889200B2 (en) 2013-07-31 2018-02-13 Qbi Enterprises Ltd. Sphingolipid-polyalkylamine-oligonucleotide compounds
US20160208247A1 (en) 2013-07-31 2016-07-21 Qbi Enterprises Ltd. Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
DE102013215168B4 (de) 2013-08-01 2016-01-07 Gna Biosolutions Gmbh Verwendung von einem oder mehreren Nanopartikeln zum Vervielfältigen von Nukleinsäuren
PE20160671A1 (es) 2013-08-02 2016-07-09 Pfizer Anticuerpos anti-cxcr4 y conjugados de anticuerpo y farmaco
WO2015021423A2 (fr) 2013-08-08 2015-02-12 Biogen Idec Ma Inc. Purification de molécules chimères du facteur viii
WO2015018943A2 (fr) 2013-08-08 2015-02-12 Institut Pasteur Corrélation entre une activité pathologique et des expansions clonales de cellules t cd8+ spécifiques du virus du papillome humain 16 chez des patients souffrant de lichens plans oraux érosifs sévères
US10047406B2 (en) 2013-08-14 2018-08-14 Gen-Probe Incorporated Compositions and methods for detecting HEV nucleic acid
JP6617239B2 (ja) 2013-08-14 2019-12-11 サイドゥ サチデーブ Frizzledタンパク質に対する抗体及びその使用方法
TW202003554A (zh) 2013-08-14 2020-01-16 美商百歐維拉提夫治療公司 因子viii-xten融合物及其用途
IL228026B (en) 2013-08-19 2018-05-31 Technion Res & Dev Foundation Discovery of genetic sequences using pna sensors and isotachophoresis
US20160201116A1 (en) 2013-08-20 2016-07-14 E. I. Du Pont De Nemours And Company Sequences and their use for detection of salmonella enteritidis and/or salmonella typhimurium
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
WO2015031441A2 (fr) 2013-08-27 2015-03-05 Novogy, Inc. Micro-organismes modifiés pour utiliser des sources non conventionnelles de phosphore ou du soufre
CA2922689A1 (fr) 2013-08-28 2015-03-05 Caris Life Sciences Switzerland Holdings Gmbh Sondes oligonucleotidiques et leurs utilisations
US9352021B2 (en) 2013-08-28 2016-05-31 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
CN105849117B (zh) 2013-08-29 2017-12-12 耶达研究及发展有限公司 Na,K‑ATP酶的α2亚型的选择性抑制剂和用于降低眼内压的用途
EP2843056B8 (fr) 2013-08-30 2019-06-26 GENINCODE UK, Ltd. Marqueurs de risque de maladie cardiovasculaire chez des patients atteints de maladie rénale chronique
GB2534067B (en) 2013-08-30 2021-07-21 Personalis Inc Methods and systems for genomic analysis
US20160251410A1 (en) 2013-09-03 2016-09-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for expressing recombinant polypeptides
IL228284A (en) 2013-09-03 2016-12-29 Technion Res & Dev Foundation Implants from cellular scaffolding and blood vessel stalk
WO2015033344A1 (fr) 2013-09-05 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés et nécessaires permettant d'inhiber la pathogénicité d'un streptocoque du groupe a (sga) ou d'un streptocoque du groupe g (sgg)
EP4074330A1 (fr) 2013-09-05 2022-10-19 Massachusetts Institute of Technology Réglage de populations microbiennes à l'aide de nucléases programmables
AU2014317990A1 (en) 2013-09-06 2016-02-25 Theranos Ip Company, Llc Systems and methods for detecting infectious diseases
EP3044593A4 (fr) 2013-09-09 2017-05-17 Triact Therapeutics, Inc. Traitement du cancer
CA2923166A1 (fr) 2013-09-09 2015-03-12 British Columbia Cancer Agency Branch Procedes et kits de prevision de resultat et procedes et kits pour le traitement du cancer du sein par radiotherapie
CN105636614A (zh) 2013-09-09 2016-06-01 菲格内有限责任公司 用于软骨细胞或软骨型细胞再生的基因治疗
EP3044313B1 (fr) 2013-09-12 2019-11-06 Danisco US Inc. Compositions et méthodes comprenant des variants de protéases du clade lg12
WO2015037009A1 (fr) 2013-09-16 2015-03-19 Plexicure Ltd. Protéines isolées capables de se lier à la plexine-a4, et procédés de production et d'utilisation
US9695402B2 (en) 2013-09-17 2017-07-04 Yeda Research And Development Co. Ltd. ERK-derived peptides and uses thereof
US9828600B2 (en) 2013-09-20 2017-11-28 University Of Massachusetts Compositions and methods for constructing cDNA libraries that allow for mapping the 5′ and 3′ ends of RNAs
TW201610151A (zh) 2013-09-23 2016-03-16 阿尼拉製藥公司 治療或預防與甲狀腺素運載蛋白相關疾病之方法
ES2724300T3 (es) 2013-09-25 2019-09-10 Univ Cornell Compuestos para inducir inmunidad antitumoral y métodos de lo mismo
US10570204B2 (en) 2013-09-26 2020-02-25 The Medical College Of Wisconsin, Inc. Methods for treating hematologic cancers
DK3418929T3 (da) 2013-09-27 2021-02-01 Codexis Inc Automatiseret screening af enzymvarianter
US20160237404A1 (en) 2013-10-01 2016-08-18 Kadimastem Ltd. Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic laterial sclerosis (als)
EP3052121B1 (fr) 2013-10-02 2023-02-22 The Board of Trustees of the Leland Stanford Junior University Compositions wnt et procédés de purification
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
WO2015049370A1 (fr) 2013-10-03 2015-04-09 Novozymes A/S Composition détergente et utilisation de celle-ci
AU2014329535B2 (en) 2013-10-03 2017-09-07 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
JP6525434B2 (ja) 2013-10-04 2019-06-05 セクエノム, インコーポレイテッド 遺伝子の変異の非侵襲的な評価のための方法および処理
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015051338A1 (fr) 2013-10-04 2015-04-09 Life Technologies Corporation Procédés et systèmes de modélisation des effets de suppression dans le séquençage utilisant la chimie de terminaison
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム, インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
EP3058339B1 (fr) 2013-10-07 2019-05-22 APDN (B.V.I.) Inc. Lecteur multimode d'image et spectral
AU2014336962B2 (en) 2013-10-15 2019-07-25 Bio Molecular Systems Pty Ltd Improved thermocycler
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
US11049587B2 (en) 2013-10-18 2021-06-29 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
WO2015058095A1 (fr) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Procédés et systèmes de quantification d'alignement de séquences
AU2014337089B2 (en) 2013-10-18 2019-08-08 Seven Bridges Genomics Inc. Methods and systems for genotyping genetic samples
JP2016533182A (ja) 2013-10-18 2016-10-27 セブン ブリッジズ ジェノミクス インコーポレイテッド 疾患に誘導された変異を同定するための方法およびシステム
CA2928269C (fr) 2013-10-21 2023-03-14 Opko Biologics Ltd. Polypeptides a action prolongee et procedes de production et d'administration de ceux-ci
JP6325667B2 (ja) 2013-10-21 2018-05-16 キム・ソンチョン オリゴヌクレオチドを用いた生体分子分析方法及び装置
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
WO2015059690A1 (fr) 2013-10-24 2015-04-30 Yeda Research And Development Co. Ltd. Polynucléotides codant pour des polypeptides de système brex et leurs méthodes d'utilisation
WO2015061548A1 (fr) 2013-10-25 2015-04-30 Pioneer Hi-Bred International, Inc. Sojas tolérants à la jambe noire, et procédés d'utilisation
US10779518B2 (en) 2013-10-25 2020-09-22 Livestock Improvement Corporation Limited Genetic markers and uses therefor
AU2014339843B2 (en) 2013-10-25 2019-04-04 Qurgen, Inc. Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming
US9914964B2 (en) 2013-10-25 2018-03-13 Life Technologies Corporation Compounds for use in PCR systems and applications thereof
US10351918B2 (en) 2013-10-30 2019-07-16 Green Life Biotech, Llc Pathogenesis quantification systems and treatment methods for citrus greening blight
EP3062809B1 (fr) 2013-10-31 2020-07-08 Biokine Therapeutics Ltd. Un inhibiteur peptidique de cxcr4 pour le traitement de la leucémie myéloïde aiguë avec mutation de la flt3
US10988745B2 (en) 2013-10-31 2021-04-27 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
WO2015063604A2 (fr) 2013-11-01 2015-05-07 Imberti Luisa Biomarqueurs prédictifs de la réponse thérapeutique à ifnβ et utilisations de ceux-ci
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
RU2694950C2 (ru) 2013-11-04 2019-07-18 Монсанто Текнолоджи Ллс Композиции и способы для борьбы с членистоногими паразитами и заражениями вредителями
CN104623637A (zh) 2013-11-07 2015-05-20 健能隆医药技术(上海)有限公司 Il-22二聚体在制备静脉注射药物中的应用
EP3065775B1 (fr) 2013-11-08 2020-09-30 The Board of Regents of the University of Texas System Anticorps vh4 dirigés contre les astrocytes et les neurones de la matière grise
WO2015070050A1 (fr) 2013-11-08 2015-05-14 Baylor Research Institute La localisation nucléaire de glp-1 stimule la régénération myocardique et entraîne la régression d'une insuffisance cardiaque
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
US10364465B2 (en) 2013-11-12 2019-07-30 Life Technologies Corporation Reagents and methods for sequencing
SG10201810298VA (en) 2013-11-13 2018-12-28 Pfizer Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
JP2016536995A (ja) 2013-11-14 2016-12-01 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド 増大した鋳型識別活性を有するdnaポリメラーゼ突然変異体
BR112016011046A2 (pt) 2013-11-15 2019-01-29 Centre Nat Rech Scient método para genotipagem, método para a detecção de uma infecção, kit para detectar uma infecção e método para detectar em uma amostra biológica.
WO2015075166A1 (fr) 2013-11-22 2015-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter une infection bactérienne
CA2931322A1 (fr) 2013-11-22 2015-05-28 Dnatrix, Inc. Agonistes des recepteurs stimulateurs de cellules immunitaires exprimant l'adenovirus
WO2015077717A1 (fr) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions et méthodes pour diagnostiquer, évaluer et traiter un cancer au moyen d'un état de méthylation d'adn
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
CN113528632A (zh) 2013-11-26 2021-10-22 伊鲁米那股份有限公司 用于多核苷酸测序的组合物和方法
NZ630717A (en) 2013-11-27 2016-04-29 Seminis Vegetable Seeds Inc Disease resistance loci in onion
EP3074025A1 (fr) 2013-11-27 2016-10-05 Baylor College Of Medicine Récepteur antigénique chimère spécifique de cspg4 utilisable contre le cancer
CA2925698C (fr) 2013-11-28 2021-11-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Inhibiteurs de l'arn polymerase i et leurs utilisations
US10890559B2 (en) 2013-11-29 2021-01-12 Technion Research & Development Foundation Limited Method and device for accelerated surface-based reactions
EP2878681B1 (fr) 2013-11-29 2020-03-04 Technion Research And Development Foundation, Ltd. Détection continue de cellule par isotachophorèse
US10927408B2 (en) 2013-12-02 2021-02-23 Personal Genome Diagnostics, Inc. Method for evaluating minority variants in a sample
WO2015082536A1 (fr) 2013-12-03 2015-06-11 Evaxion Biotech Aps Protéines et acides nucléiques utiles dans des vaccins ciblant staphylococcus aureus
WO2015085147A1 (fr) 2013-12-05 2015-06-11 The Broad Institute Inc. Typage de gènes polymorphes et détection de changements somatiques à l'aide de données de séquençage
WO2015085299A1 (fr) 2013-12-06 2015-06-11 Altria Client Services Inc. Plantes de tabac présentant des quantités modifiées d'un ou de plusieurs alcaloïdes dans leurs feuilles et procédés d'utilisation de telles plantes
EP2986719B1 (fr) 2013-12-06 2020-07-29 Bio-Rad Laboratories, Inc. Polymérases de fusion
DK3080243T3 (en) 2013-12-10 2019-01-07 Yeda Res & Dev USE OF ENZYMES THAT CATALYZE PYRUVATH SYNTHESIS FROM FORMIATE AND ACETYL COA, AND BACTERIES THAT EXPRESS THIS
WO2015087187A1 (fr) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anticorps anti-sclérostine
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
AU2014362262B2 (en) 2013-12-12 2021-05-13 Alnylam Pharmaceuticals, Inc. Complement component iRNA compositions and methods of use thereof
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
US10280431B2 (en) 2013-12-18 2019-05-07 Nutech Ventures Acyltransferases and methods of using
EP3083936B1 (fr) 2013-12-19 2018-07-04 Danisco US Inc. Utilisation d'hydrophobines pour augmenter le transfert de gaz dans des processus de fermentation aérobie
GB201322574D0 (en) 2013-12-19 2014-02-05 Equigerminal Sa Retroviral peptides
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
KR20230076867A (ko) 2013-12-20 2023-05-31 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
HUE056297T2 (hu) 2013-12-20 2022-02-28 Astex Therapeutics Ltd Biciklikus heterociklusos vegyületek és ezek terápiában történõ alkalmazása
US20150176060A1 (en) 2013-12-20 2015-06-25 Roche Molecular Systems, Inc. Method For Coding Of Multiple PCR Reactions For Assay Recognition
US9243289B2 (en) 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
RS63295B1 (sr) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Anti-vista antitela i fragmenti
EP3087394A2 (fr) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Profils de biomarqueur pour prédire les résultats d'une thérapie cancéreuse utilisant des inhibiteurs d'erbb3 et/ou des chimiothérapies
DK3089822T3 (da) 2013-12-30 2022-05-02 Atreca Inc Analyse af nukleinsyrer associeret med enkelte celler under anvendelse af nukleinsyrestregkoder
EP2889382A1 (fr) 2013-12-30 2015-07-01 Centrum Badan DNA Sp. z o.o. Oligonucléotides, leur utilisation, méthodes et trousse pour la détection d'ADN de Borrelia burgdorferi, Bartonella henselae, Babesia divergens, Anaplasma phagocytophilum
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
UY35928A (es) 2013-12-31 2015-07-31 Dow Agrosciences Llc ?GEN Rf3 RESTAURADOR DE LA ANDROESTERILIDAD CITOPLASMÁTICA (CMS) TIPO S?.
MX2016008595A (es) 2013-12-31 2016-10-28 Danisco Us Inc Expresion mejorada de proteínas.
ES2819865T3 (es) 2014-01-07 2021-04-19 Bioatla Llc Proteínas dirigidas a ortólogos
US9354175B2 (en) 2014-01-10 2016-05-31 Lucigen Corporation Lucigen yellow (LucY), a yellow fluorescent protein
CN117106095A (zh) 2014-01-10 2023-11-24 比奥贝拉蒂治疗公司 因子viii嵌合蛋白及其用途
JP6739339B2 (ja) 2014-01-15 2020-08-12 アボット・ラボラトリーズAbbott Laboratories カバーされた配列変換dnaおよび検出方法
US10334848B2 (en) 2014-01-15 2019-07-02 Monsanto Technology Llc Methods and compositions for weed control using EPSPS polynucleotides
WO2015109212A1 (fr) 2014-01-17 2015-07-23 Pfizer Inc. Anticorps anti-il-2 et compositions et utilisations de ceux-ci
US10392629B2 (en) 2014-01-17 2019-08-27 Board Of Trustees Of Michigan State University Increased caloric and nutritional content of plant biomass
CN106164261A (zh) 2014-01-22 2016-11-23 生命技术公司 适用于高温核酸合成的新颖逆转录酶
US9714429B2 (en) 2014-01-28 2017-07-25 Arkansas State University Regulatory sequence of cupin family gene
MX2016009954A (es) 2014-01-29 2017-02-23 Dana Farber Cancer Inst Inc Anticuerpos contra el dominio extracelular de muc1-c (muc1-c/ecd).
WO2015114633A1 (fr) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Peptides se liant à l'actine et compositions les contenant pour inhiber l'angiogenèse et traiter des affections médicales associées à celle-ci
GB201401648D0 (en) 2014-01-31 2014-03-19 Dupont Nutrition Biosci Aps Protein
EP3099792B1 (fr) 2014-01-31 2018-10-17 Danisco US Inc. Procédé pour améliorer les produits secondaires de procédés de fermentation à l'aide de xylanase
WO2015117033A2 (fr) 2014-01-31 2015-08-06 Biogen Ma Inc. Méthodes d'augmentation de production de protéines dans des cellules de mammifères
WO2015113725A1 (fr) 2014-02-03 2015-08-06 Thermo Fisher Scientific Baltics Uab Procédé de fragmentation régulée de l'adn
CN106470699A (zh) 2014-02-03 2017-03-01 耶路撒冷希伯来大学的益生研究开发有限公司 使用酪蛋白激酶i抑制剂以消耗干细胞的用途
CA2935195A1 (fr) 2014-02-03 2015-08-06 Bioasis Technologies, Inc. Proteines hybrides p97
CN111733231A (zh) 2014-02-05 2020-10-02 耶达研究及发展有限公司 用于治疗和诊断的微rna和包含所述微rna的组合物
US10066014B2 (en) 2014-02-06 2018-09-04 Yeda Research And Development Co. Ltd. Anti CD84 antibodies, compositions comprising same and uses thereof
WO2015120403A1 (fr) 2014-02-08 2015-08-13 The Regents Of The University Of Colorado, A Body Corporate Pcr de liaison multiplexée
WO2015118547A1 (fr) 2014-02-10 2015-08-13 Protalix Ltd. Méthode de maintien de la stabilité d'une maladie chez un sujet atteint de la maladie de gaucher
CA2937305C (fr) 2014-02-11 2020-12-15 Brainstorm Cell Therapeutics Ltd. Composition pharmaceutique comprenant des cellules souches mesenchymateuses derivees de moelle osseuse
JP6494045B2 (ja) 2014-02-11 2019-04-03 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 標的シーケンシングおよびuidフィルタリング
US20150232578A1 (en) 2014-02-14 2015-08-20 Symvivo Corporation Hybrid proteins and uses thereof
US10598672B2 (en) 2014-02-18 2020-03-24 Cyrano Therapeutics, Inc. Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
ES2762672T3 (es) 2014-02-19 2020-05-25 Bioasis Technologies Inc Proteínas de fusión de P97-IDS
UA122122C2 (uk) 2014-02-21 2020-09-25 Сінгента Партісіпейшнс Аг Спосіб виявлення рослини маїсу, що має підвищену чоловічу фертильність
KR102328069B1 (ko) 2014-02-21 2021-11-17 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 알로스테릭 단백질의 신생 설계
EP3110976B1 (fr) 2014-02-27 2020-05-13 Biogen MA Inc. Procédé d'évaluation du risque de lemp
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
WO2015130968A2 (fr) 2014-02-27 2015-09-03 The Broad Institute Inc. Expression de gènes d'équilibrage des lymphocytes t, compositions de substances et leurs procédés d'utilisation
US20160369343A1 (en) 2014-02-28 2016-12-22 Friedrich Miescher Institute For Biomedical Research Prediction of preeclampsia using microrna
US20170067894A1 (en) 2014-03-03 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method and device for detection of pseudomonas aeruginosa
WO2015134787A2 (fr) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Procédés dans lesquels on utilise des molécules synthétiques contenant des randomères
EP3117011B1 (fr) 2014-03-13 2020-05-06 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
EP3116305B1 (fr) 2014-03-14 2023-12-06 Cibus US LLC Procédés et compositions permettant d'améliorer l'efficacité de modifications génétiques ciblées en utilisant la réparation de gène médiée par des oligonucléotides
US9951392B2 (en) 2014-03-14 2018-04-24 Northwestern University Substrate replenishment and byproduct removal improve yeast cell-free protein synthesis
WO2015142990A1 (fr) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Marqueurs optiques cryptés pour applications de sécurité
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
WO2015143400A1 (fr) 2014-03-20 2015-09-24 Pharmacyclics, Inc. Mutations de phospholipase c gamma 2 et associées aux résistances
EP3119429A4 (fr) 2014-03-21 2018-04-04 Nutech Ventures Virus du syndrome dysgénésique et respiratoire du porc (prrsv) d'origine non naturelle et procédés d'utilisation
WO2015143409A1 (fr) 2014-03-21 2015-09-24 Labrys Biologics, Inc. Anticorps antagonistes dirigés contre le peptide lié au gène de la calcitonine et leurs procédés d'utilisation
EP3848034A1 (fr) 2014-03-26 2021-07-14 Astex Therapeutics Limited Combinaisons
CN106456648B (zh) 2014-03-26 2021-11-02 阿斯特克斯治疗有限公司 Fgfr抑制剂和igf1r抑制剂的组合
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
US20170136102A1 (en) 2014-03-27 2017-05-18 Umender Kumar SHARMA Phage-derived compositions for improved mycobacterial therapy
WO2015148919A2 (fr) 2014-03-27 2015-10-01 Yale University Micro-arn circulants en tant que biomarqueurs pour l'endométriose
EP2923709A1 (fr) 2014-03-28 2015-09-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vaccin contre la malaria multi-composants-multi-étapes
US10857219B2 (en) 2014-03-28 2020-12-08 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof
WO2015147370A1 (fr) 2014-03-28 2015-10-01 Seegene, Inc. Détection de séquences d'acide nucléique cible à l'aide de différentes températures de détection
EP3125936B1 (fr) 2014-03-31 2019-05-08 Debiopharm International SA Fusions de fgfr
US20170121741A1 (en) 2014-04-01 2017-05-04 Dupont Nutrition Biosciences Aps Method for increasing crude palm oil yields
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
CN106413390B (zh) 2014-04-01 2019-09-27 孟山都技术公司 用于控制虫害的组合物和方法
ES2786226T3 (es) 2014-04-02 2020-10-09 Univ California Un módulo de válvula de purga molecular bioquímico sintético que mantiene el equilibrio de cofactores
EP3129491A1 (fr) 2014-04-08 2017-02-15 Altria Client Services LLC Tabac dont les feuilles présentent des propriétés modifiées et ses procédés de production et d'utilisation
EP3129493B1 (fr) 2014-04-09 2021-07-07 The Scripps Research Institute Importation de triphosphates de nucléosides non naturels ou modifiés dans des cellules par l'intermédiaire de transporteurs de triphosphates d'acide nucléique
EP3129075A4 (fr) 2014-04-10 2017-12-06 Bonus Therapeutics Ltd. Compositions pour la réparation des os
PT4026917T (pt) 2014-04-14 2024-02-12 Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd Método e kit para determinar a morte de células ou de tecido ou a origem de tecidos ou de células de dna por análise de metilação do dna
WO2015160986A2 (fr) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Polythérapies
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US9598678B2 (en) 2014-04-17 2017-03-21 Nutech Ventures Microbial strains and methods of making and using
WO2015159295A1 (fr) 2014-04-17 2015-10-22 Yeda Research And Development Co. Ltd. Procédés et kits pour analyser les fragments se liant à l'adn liés à l'adn
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US20170107486A1 (en) 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US20160053302A1 (en) 2014-04-22 2016-02-25 Roche Molecular Systems, Inc. Method for visual identification of pcr solutions for accurate reaction setup
CA2944903A1 (fr) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Suppresseur de tumeur et biomarqueurs oncogenes predictifs de reponse a un inhibiteur de point de controle anti-immunitaire
AU2015254886A1 (en) 2014-04-27 2016-11-03 Ccam Biotherapeutics Ltd. Humanized antibodies against CEACAM1
US11427647B2 (en) 2014-04-27 2022-08-30 Famewave Ltd. Polynucleotides encoding humanized antibodies against CEACAM1
ES2870658T3 (es) 2014-04-28 2021-10-27 Yeda Res & Dev Respuesta del microbioma a agentes
JP6847664B2 (ja) 2014-05-01 2021-03-24 バイオアシス テクノロジーズ インコーポレイテッド P97−ポリヌクレオチド複合体
WO2015168531A1 (fr) 2014-05-01 2015-11-05 Novogy, Inc. Augmentation de la production de lipides cellulaires par augmentation de l'activité de la diacylglycérol acyltransférase et diminution de l'activité de la triacylglycérol lipase
CA2945736A1 (fr) 2014-05-04 2015-11-12 Forrest Innovations Ltd. Compositions de lutte contre les moustiques et leurs utilisations
WO2015172083A1 (fr) 2014-05-08 2015-11-12 Biogen Ma Inc. Diméthylfumarate et promédicaments pour le traitement de la sclérose en plaques
MX2016014558A (es) 2014-05-09 2018-03-12 Biosearch Tech Inc Extinguidores de fluorescencia "cosmic quenchers".
WO2015175530A1 (fr) 2014-05-12 2015-11-19 Gore Athurva Procédés pour la détection d'aneuploïdie
WO2015175576A2 (fr) 2014-05-12 2015-11-19 The Board Of Trustees Of The University Of Illinois Protéases plus performantes pour le retrait d'étiquette sans cicatrice
WO2015175424A1 (fr) 2014-05-12 2015-11-19 Biogen Ma Inc. Biomarqueurs prédictifs de l'évolution du lupus et utilisations de ceux-ci
ES2902484T3 (es) 2014-05-16 2022-03-28 Univ Yale Composiciones para el tratamiento y la prevención de la pancreatitis y las lesiones renales
EP3143166A4 (fr) 2014-05-16 2018-04-18 University of Massachusetts Traitement de la leucémie myéloïde chronique (lmc)
US20150329898A1 (en) 2014-05-19 2015-11-19 Amplicon Express Mate-Pair Sequences from Large Inserts
US10294482B2 (en) 2014-05-22 2019-05-21 Yeda Research And Development Co. Ltd. Recombinant microorganisms capable of carbon fixation
WO2015183837A1 (fr) 2014-05-27 2015-12-03 Brian Haynes Compositions, procedes, et utilisations associees a des fusions ntrk2-tert
WO2015183836A1 (fr) 2014-05-27 2015-12-03 Brian Haynes Compositions, procédés et utilisations relatifs à des fusions ntrk2-tert
US10041120B2 (en) 2014-05-28 2018-08-07 Scripps Health Predictive analysis for myocardial infarction
US10724041B2 (en) 2014-05-29 2020-07-28 Novogy, Inc. Increasing lipid production and optimizing lipid composition
AU2015266724B2 (en) 2014-05-29 2021-09-23 Ginkgo Bioworks, Inc. Increasing lipid production in oleaginous yeast
US20170095512A1 (en) 2014-06-02 2017-04-06 Kadimastem Ltd. Methods of inducing myelination and maturation of oligodendrocytes
WO2015186129A1 (fr) 2014-06-02 2015-12-10 Technion Research & Development Foundation Limited. Compositions et procédés d'inhibition sélective d'irp1 et traitement de l'inflammation
US10745761B2 (en) 2014-06-02 2020-08-18 Valley Health System Method and systems for lung cancer diagnosis
EP3151733B1 (fr) 2014-06-06 2020-04-15 The Regents Of The University Of Michigan Compositions et méthodes de caractérisation et de diagnostic d'une maladie parodontale
US9670537B2 (en) 2014-06-06 2017-06-06 Titan Collaborative Kithe, Llc Borrelia Provocation Procedure kit
ES2891555T3 (es) 2014-06-10 2022-01-28 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
WO2015191916A1 (fr) 2014-06-11 2015-12-17 Micronics, Inc. Cartouches microfluidiques et appareil à témoins de dosage intégrés pour l'analyse d'acides nucléiques
US11123426B2 (en) 2014-06-11 2021-09-21 The Trustees Of Dartmouth College Use of vista agonists and antagonists to suppress or enhance humoral immunity
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗her2表位之單株抗體及其使用之方法
CA2953347A1 (fr) 2014-06-23 2015-12-30 Monsanto Technology Llc Compositions et methodes de regulation de l'expression genetique par interference par arn
US10308935B2 (en) 2014-06-23 2019-06-04 Friedrich Miescher Institute For Biomedical Research Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS
US9371546B2 (en) 2014-06-24 2016-06-21 E I Du Pont De Nemours And Company Enhancing D-xylose and L-arabinose utilization in Zymomonas cells
WO2015198320A1 (fr) 2014-06-24 2015-12-30 Insight Biopharmaceuticals Ltd. Procédés de purification d'anticorps
WO2015200541A1 (fr) 2014-06-24 2015-12-30 Bio-Rad Laboratories, Inc. "barcoding" par pcr numérique
CN106537148B (zh) 2014-06-25 2019-10-11 泰尔哈绍梅尔医学研究基础设施和服务有限公司 癌症干细胞的鉴定及其用于诊断和治疗的用途
US11807857B2 (en) 2014-06-25 2023-11-07 Monsanto Technology Llc Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
US10640833B2 (en) 2014-06-26 2020-05-05 University Of Florida Research Foundation, Inc. Rapid detection of infectious agents
EP3160448A4 (fr) 2014-06-26 2018-11-14 Ramot at Tel-Aviv University Ltd. Formulations de liposome pour l'administration d'acides nucléiques
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
WO2016004113A1 (fr) 2014-06-30 2016-01-07 Biogen Ma Inc. Gène du facteur ix optimisé
US9737598B2 (en) 2014-06-30 2017-08-22 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
US10113174B2 (en) 2014-07-02 2018-10-30 Altria Client Services Llc Tobacco having altered leaf properties and methods of making and using
WO2016007632A1 (fr) 2014-07-08 2016-01-14 Altria Client Services Llc Locus génétique à l'origine d'un faible caractère anatabine chez le tabac et ses procédés d'utilisation
WO2016005985A2 (fr) 2014-07-09 2016-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthode pour reprogrammer des cellules
EP3169310A1 (fr) 2014-07-15 2017-05-24 Life Technologies Corporation Compositions comprenant des agrégats lipidiques et procédés d'administration efficace de molécules dans des cellules
WO2016010856A1 (fr) 2014-07-15 2016-01-21 Qiagen Sciences, Llc Codes à barres semi-aléatoires pour l'analyse d'acides nucléiques
ES2799404T3 (es) 2014-07-15 2020-12-17 Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd Polipéptidos de CD44 aislados y usos de los mismos
US10364458B2 (en) 2014-07-16 2019-07-30 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
WO2016011268A1 (fr) 2014-07-17 2016-01-21 Beth Israel Deaconess Medical Center, Inc. Acide tout-trans-rétinoïque (atra) pour moduler l'activité et la stabilité de pin1
WO2016011432A2 (fr) 2014-07-17 2016-01-21 Czerniecki Brian J Identification de peptides immunogènes de classe ii du complexe majeur d'histocompatibilité pour une immunothérapie
US10351914B2 (en) 2014-07-17 2019-07-16 Beth Israel Deaconess Medical Center, Inc. Biomarkers for Pin1-associated disorders
LT3172232T (lt) 2014-07-17 2024-02-12 Novo Nordisk A/S Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti
US9790509B2 (en) 2014-07-18 2017-10-17 Oregon Health & Science University 5′-triphosphate oligoribonucleotides
US10550439B2 (en) 2014-07-21 2020-02-04 Novellusdx Ltd. Methods for determining drug response of patient specific mutations
CA2955414A1 (fr) 2014-07-21 2016-01-28 Novellusdx Ltd. Procedes et systemes pour determiner un indice oncogenique de mutations specifiques d'un patient
WO2016014493A1 (fr) 2014-07-22 2016-01-28 Bio-Rad Laboratories, Inc. Tampons pour une utilisation avec des polymérases
CN107087416A (zh) 2014-07-24 2017-08-22 泰拉瑞亚控股公司 变体硫酯酶及使用方法
RU2021123470A (ru) 2014-07-29 2021-09-06 Монсанто Текнолоджи Ллс Композиции и способы борьбы с насекомыми-вредителями
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US11920164B2 (en) 2014-07-30 2024-03-05 Yeda Research And Development Co. Ltd. Media for culturing naive human pluripotent stem cells
WO2016025645A1 (fr) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un bloqueur de point de contrôle immunitaire
CN111624346A (zh) 2014-08-14 2020-09-04 米密德诊断学有限公司 用于预测及/或决定预后的套组
WO2016030899A1 (fr) 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Méthodes de traitement de la sclérose latérale amyotrophique
US10925953B2 (en) 2014-08-28 2021-02-23 Yale University Compositions and methods for treating an inflammatory disease or disorder
ES2644949T3 (es) 2014-08-28 2017-12-01 F. Hoffmann-La Roche Ag Oligonucleótidos para controlar la amplificación de ácidos nucleicos
US10118950B2 (en) 2014-08-30 2018-11-06 Northwestern University Platforms for cell-free protein synthesis comprising extracts from genomically recoded E. coli strains having genetic knock-out mutations in release factor 1 (RF-1) and endA
CA2959786A1 (fr) 2014-09-03 2016-03-10 Bioatla, Llc Decouverte et production de proteines biologiques conditionnellement actives dans les memes cellules hotes eucaryotes de production
WO2016038609A1 (fr) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anticorps anti-her3 et leurs utilisations
EP2992895A1 (fr) 2014-09-08 2016-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vaccin contre la malaria multi-composants-multi-étapes
WO2016038610A1 (fr) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions et procédés de traitement d'un cancer résistant à un inhibiteur de la tyrosine kinase (tki)
EP3191605B1 (fr) 2014-09-09 2022-07-27 The Broad Institute, Inc. Procédé à base de gouttelettes et appareil pour l'analyse composite d'acide nucléique de cellules uniques
EP3913066A1 (fr) 2014-09-09 2021-11-24 Igenomx International Genomics Corporation Compositions pour la préparation de banques d'acides nucléiques rapides
EP3191186B1 (fr) 2014-09-10 2021-01-27 Georgetown University Compositions et procédés d'utilisation de l'il4i1 (interleukine-4 induced gene 1)
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
AU2015314813B2 (en) 2014-09-11 2022-02-24 Immunis.Ai, Inc. Methods of detecting prostate cancer
EP3191591A1 (fr) 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Agents polynucléotidiques ciblant le composant du complément c5 et leurs méthodes d'utilisation
IL234638A0 (en) 2014-09-14 2014-12-02 Yeda Res & Dev NMDA receptor antagonists for the treatment of Gaucher disease
SG10201911069WA (en) 2014-09-15 2020-01-30 Abvitro Llc High-throughput nucleotide library sequencing
WO2016044673A1 (fr) 2014-09-17 2016-03-24 Theranos, Inc. Amplification d'acide nucléique multi-étapes hybride
WO2016044510A1 (fr) 2014-09-17 2016-03-24 Hologic, Inc. Procédé de lyse partielle et dosage
US10125382B2 (en) 2014-09-18 2018-11-13 Corbion Biotech, Inc. Acyl-ACP thioesterases and mutants thereof
EP3230453B1 (fr) 2014-09-21 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Freination du mir-132 pour le traitement de troubles lipidiques
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
EP3224595A4 (fr) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Commande de procédé pour accroître la robustesse de tests génétiques
WO2016049459A1 (fr) 2014-09-26 2016-03-31 Baylor College Of Medicine Récepteurs d'antigènes chimériques spécifiques de cd3 pour l'immunothérapie adoptive
RU2017114964A (ru) 2014-10-02 2018-11-07 Протива Байотерапьютикс, Инк. Композиции и способы для подавления экспрессии гена вируса гепатита в
EP3201356A1 (fr) 2014-10-03 2017-08-09 Life Technologies Corporation Compositions, méthodes et kits de vérification de séquence génétique
EP3739053B1 (fr) 2014-10-06 2023-08-30 Altria Client Services LLC Régulation génétique de la croissance de bourgeons axillaires dans des plantes de tabac
WO2016057367A1 (fr) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Biomarqueurs à base d'angiopoïétine -2 utilisés pour la prédiction de la réponse de point de contrôle anti-immunitaire
WO2016057705A1 (fr) 2014-10-08 2016-04-14 Novartis Ag Biomarqueurs prédictifs de la réactivité thérapeutique à une thérapie par récepteurs antigéniques chimères et leurs utilisations
CN113230384A (zh) 2014-10-09 2021-08-10 丹娜法伯癌症研究院 用于治疗免疫失调的多次-可变il-2剂量方案
EP3005862A1 (fr) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Plants de melon présentant une meilleure tolérance aux maladies
JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
EP3207156A1 (fr) 2014-10-13 2017-08-23 Life Technologies Corporation Procédés, kits et compositions pour déterminer des nombres de copies de gène
WO2016060974A1 (fr) 2014-10-13 2016-04-21 Life Technologies Corporation Procédés, systèmes, et supports lisibles par ordinateur pour appel de bases accéléré
ES2759337T3 (es) 2014-10-14 2020-05-08 Abbott Lab ADN de conversión de secuencia y ADN amplificador de señal que tiene secuencias espaciadoras de poli-ADN y métodos de detección que los utilizan
WO2016089477A1 (fr) 2014-10-16 2016-06-09 Cepheid Système et procédé de criblage biosécuritaire
WO2016061514A1 (fr) 2014-10-17 2016-04-21 Good Start Genetics, Inc. Criblage génétique de pré-implantation et détection d'aneuploïdie
EP3207138B1 (fr) 2014-10-17 2020-07-15 Alnylam Pharmaceuticals, Inc. Agents polynucléotidiques de ciblage d'acide aminolévulinique synthase-1 (alas1) et utilisations de ceux-ci
GB2536745B (en) 2014-10-20 2019-06-26 Gen Probe Inc Red Blood cell lysis solution
WO2016063122A1 (fr) 2014-10-20 2016-04-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de criblage d'un sujet pour dépister un cancer
US20170306360A1 (en) 2014-10-24 2017-10-26 Danisco Us Inc. Method for producing alcohol by use of a tripeptidyl peptidase
US20170325479A1 (en) 2014-10-24 2017-11-16 Dupont Nutrition Biosciences Aps Proline tolerant tripeptidyl peptidases and uses thereof
EP3212790B1 (fr) 2014-10-29 2020-03-25 Adaptive Biotechnologies Corp. Détection simultanée hautement multiplexée d'acides nucléiques codant pour des hétérodimères de récepteurs de l'immunité adaptative appariés à partir de nombreux échantillons
EP3904519A1 (fr) 2014-10-30 2021-11-03 Genzyme Corporation Agents polynucléotidiques ciblant serpinc 1 (at3) et leurs méthodes d'utilisation
EP3212808B1 (fr) 2014-10-30 2022-03-02 Personalis, Inc. Procédés d'utilisation du mosaïcisme dans des acides nucléiques prélevés de façon distale par rapport à leur origine
US11559801B2 (en) 2014-11-03 2023-01-24 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
WO2016071727A1 (fr) 2014-11-04 2016-05-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes pour la prévention et le traitement de la glomérulonéphrite rapidement progressive
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
US10544450B2 (en) 2014-11-07 2020-01-28 Gna Biosolutions Gmbh Method for duplicating nucleic acids by means of a polymerase chain reaction
WO2016074701A1 (fr) 2014-11-10 2016-05-19 Gna Biosolutions Gmbh Procédé de multiplication d'acides nucléiques
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
EP3218482A4 (fr) 2014-11-11 2018-05-09 Abbott Molecular Inc. Sondes d'hybridation et procédés associés
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
JP2017537084A (ja) 2014-11-12 2017-12-14 トラコン ファーマシューティカルズ、インコーポレイテッド 抗エンドグリン抗体及びその用途
EP3218002B1 (fr) 2014-11-13 2020-08-19 Evaxion Biotech ApS Peptides dérivés d'acinetobacter baumannii et leur utilisation en vaccination
ES2965744T3 (es) 2014-11-13 2024-04-16 Enzootic Holdings Ltd Inversión sexual funcional de crustáceos decápodos hembras
CA2967036A1 (fr) 2014-11-13 2016-05-19 The Board Of Trustees Of The University Of Illinois "super" helicases hyper-fonctionnelle bio-modifiees
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP4151733A1 (fr) 2014-11-14 2023-03-22 BASF Plant Science Company GmbH Modification de lipides végétaux contenant des acides gras polyinsaturés stabilisés
EP3220810A4 (fr) 2014-11-17 2018-05-16 Boston Heart Diagnostic Corporation Évaluation du risque de maladie cardiovasculaire
EP3220945A2 (fr) 2014-11-17 2017-09-27 Yeda Research and Development Co., Ltd. Procédés de traitement de maladies associées à une fonction mitochondriale
CN107429291A (zh) 2014-11-17 2017-12-01 耶达研究及发展有限公司 分析微生物组的方法
SG11201704058TA (en) 2014-11-18 2017-06-29 Janssen Pharmaceutica Nv Cd47 antibodies, methods, and uses
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US10889631B2 (en) 2014-11-20 2021-01-12 Cytonics Corporation Therapeutic variant alpha-2-macroglobulin compositions
EP3221341B1 (fr) 2014-11-20 2020-07-29 Cytonics Corporation Compositions à variant thérapeutique d'alpha-2-macroglobuline
EP3221455B1 (fr) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions et procédés de production de polypeptides présentant un schéma de glycosylation modifié dans des cellules végétales
US10053676B2 (en) 2014-11-25 2018-08-21 Bio-Rad Laboratories, Inc. Arginine improves polymerase storage stability
EP3224353B9 (fr) 2014-11-26 2023-08-09 Technology Innovation Momentum Fund (Israel) Limited Partnership Élimination ciblée de gènes bactériens
GB2548059B (en) 2014-11-26 2020-09-02 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
WO2016086227A2 (fr) 2014-11-26 2016-06-02 The Regents Of The University Of California Compositions thérapeutiques comprenant des facteurs de transcription et leurs procédés de préparation et d'utilisation
KR20170081268A (ko) 2014-11-27 2017-07-11 단지거 이노베이션즈 엘티디. 게놈 편집용 핵산 구조체
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
WO2016090323A1 (fr) 2014-12-05 2016-06-09 Prelude, Inc. Récurrence de carcinome canalaire in situ (dcis) et cancer du sein invasif
AU2015360903B2 (en) 2014-12-08 2021-03-25 Dana-Farber Cancer Institute, Inc. Methods for upregulating immune responses using combinations of anti-RGMB and anti-PD-1 agents
WO2016094425A1 (fr) 2014-12-08 2016-06-16 Berg Llc Utilisation de marqueurs comprenant de la filamine a dans le diagnostic et le traitement du cancer de la prostate
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
US10688330B2 (en) 2014-12-11 2020-06-23 Yeda Research And Development Co. Ltd. Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
WO2016093838A1 (fr) 2014-12-11 2016-06-16 New England Biolabs, Inc. Enrichissement en séquences cibles
JP6735277B2 (ja) 2014-12-12 2020-08-05 メディベイション プロステイト セラピューティクス エルエルシー 乳癌療法剤に対する反応を予測するための方法および乳癌の処置の方法
AU2015360352B2 (en) 2014-12-12 2022-01-27 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
US10683528B2 (en) 2014-12-16 2020-06-16 Danisco Us Inc Enhanced protein expression
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
EP3233099A1 (fr) 2014-12-17 2017-10-25 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Phagothérapie pour cibler des entérocoques
WO2016100128A1 (fr) 2014-12-19 2016-06-23 Danisco Us Inc Expression améliorée de protéine
BR112017013177A2 (pt) 2014-12-19 2018-05-15 Dana Farber Cancer Inst Inc receptores de antígeno quiméricos de anidrase carbônica ix e métodos de uso dos mesmos
EP3757211A1 (fr) 2014-12-19 2020-12-30 The Broad Institute, Inc. Procédés pour le profilage de répertoire de récepteurs de lymphocytes t
WO2016100975A1 (fr) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Biomarqueurs moléculaires pour l'immunothérapie d'un cancer
WO2016106387A2 (fr) 2014-12-22 2016-06-30 University Of Iowa Research Foundation Aptamères d'acide nucléique pour traiter des états pathologiques induits par l'histone
EP3237452A4 (fr) 2014-12-23 2018-12-05 The Trustees of Columbia University in the City of New York Protéines de fusion et procédés associés
JP6271093B1 (ja) 2014-12-23 2018-01-31 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited 免疫調節
WO2016103269A1 (fr) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations de cellules progénitrices neuronales et leurs procédés de production et d'utilisation
HUE037476T2 (hu) 2014-12-23 2018-08-28 4D Pharma Res Ltd Pirin polipeptid és immunmodulálás
US10604790B2 (en) 2014-12-24 2020-03-31 Abbott Laboratories Sequence conversion and signal amplifier DNA cascade reactions and detection methods using same
AU2015373050B2 (en) 2014-12-30 2022-09-29 Cell Cure Neurosciences Ltd. RPE cell populations and methods of generating same
EP3240890B1 (fr) 2014-12-30 2021-06-16 Cell Cure Neurosciences Ltd. Évaluation de populations de cellules épithéliales pigmentaires rétiniennes
CN107208145A (zh) 2014-12-30 2017-09-26 端粒诊断公司 多重定量pcr
BR112017014433A2 (pt) 2015-01-04 2018-05-15 Protalix Ltd. proteína dnase i modificada, processo para preparar proteína dnase i modificada e composição farmacêutica
US10066259B2 (en) 2015-01-06 2018-09-04 Good Start Genetics, Inc. Screening for structural variants
AU2016205179B2 (en) 2015-01-09 2021-06-17 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
WO2016113252A2 (fr) 2015-01-12 2016-07-21 Evaxion Biotech Aps Protéines et acides nucléiques utiles dans des vaccins ciblant le klebsiella pneumoniae
MA41346A (fr) 2015-01-12 2017-11-21 Juno Therapeutics Inc Eléments régulateurs post-transcriptionnels d'hépatite modifiée
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
WO2016116935A1 (fr) 2015-01-21 2016-07-28 Yeda Research And Development Co. Ltd. Utilisation de la rasa2 en tant que marqueur pronostique et thérapeutique pour un mélanome
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 siRNA의 공동―운반용 나노복합체 및 이의 용도
CN108064288B (zh) 2015-01-22 2021-11-26 孟山都技术公司 用于控制叶甲属的组合物和方法
WO2016118812A1 (fr) 2015-01-23 2016-07-28 Vanderbilt University Interféromètre robuste et procédés de son utilisation
JP2018504122A (ja) 2015-01-26 2018-02-15 フェイト セラピューティクス,インコーポレイテッド 免疫調節特性が増加した細胞ならびにその使用および製造のための方法
MA41433A (fr) 2015-01-26 2017-12-05 Baylor College Medicine Cellules immunitaires universelles pour l'immunothérapie anticancéreuse
EP3250675A1 (fr) 2015-01-28 2017-12-06 SABIC Global Technologies B.V. Procédés et compositions pour une production à haut rendement de biocarburant et/ou de biomasse
CA2966641A1 (fr) 2015-01-29 2016-08-04 Pioneer Hi-Bred International, Inc. Polynucleotides et kits associes a la tolerance a une carence en fer du soja et procedes de detection et de selection
CN107849123A (zh) 2015-02-02 2018-03-27 i2制药股份有限公司 抗替代性轻链抗体
CN107257854B (zh) 2015-02-02 2022-02-15 豪夫迈·罗氏有限公司 聚合酶变体
GB201501941D0 (en) 2015-02-05 2015-03-25 British American Tobacco Co Method
EP3256490A1 (fr) 2015-02-09 2017-12-20 Research Development Foundation Polypeptides ayant un domaine fc d'immunoglobuline modifié manifestant une activation du complément améliorée
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10421993B2 (en) 2015-02-11 2019-09-24 Paragon Genomics, Inc. Methods and compositions for reducing non-specific amplification products
GB201502409D0 (en) 2015-02-13 2015-04-01 British American Tobacco Co Method
AU2016219263B2 (en) 2015-02-13 2022-12-01 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
EP3486329A1 (fr) 2015-02-17 2019-05-22 Bio-Rad Laboratories, Inc. Méthode d'obtention et d'amplification d'adnc
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
KR20170116159A (ko) 2015-02-19 2017-10-18 다니스코 유에스 인크. 향상된 단백질 발현
EP3259346A4 (fr) 2015-02-20 2018-07-11 Baylor College of Medicine Inactivation de p63 pour le traitement de l'insuffisance cardiaque
CN107407685B (zh) 2015-02-20 2021-08-03 宝生物工程(美国)有限公司 快速精确分配、可视化和分析单个细胞的方法
WO2016135733A1 (fr) 2015-02-26 2016-09-01 Urifer Ltd. Modulateurs de processus de mort cellulaire
WO2016138488A2 (fr) 2015-02-26 2016-09-01 The Broad Institute Inc. Expression génique influant sur l'équilibre entre lymphocytes t, compositions de matières et leurs procédés d'utilisation
WO2016135732A1 (fr) 2015-02-26 2016-09-01 Yeda Research And Development Co. Ltd. Procédé favorisant la pousse des cheveux
WO2016138464A1 (fr) 2015-02-27 2016-09-01 Salk Institute For Biological Studies Compositions progénitrices de reprogrammation et leurs procédés d'utilisation
US10948492B2 (en) 2015-03-06 2021-03-16 Dana-Farber Cancer Institute, Inc. PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers
WO2016144891A1 (fr) 2015-03-06 2016-09-15 Bio-Rad Laboratories, Inc. Solutions d'arn stabilisées
US20180066262A1 (en) 2015-03-09 2018-03-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3268475B1 (fr) 2015-03-11 2020-10-21 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Oligonucléotides leurres pour le traitement de maladies
EP3268462B1 (fr) 2015-03-11 2021-08-11 The Broad Institute, Inc. Couplage de génotype et de phénotype
US10858401B2 (en) 2015-03-12 2020-12-08 Zoetis Services Llc Pyolysin methods and compositions
WO2016145186A1 (fr) 2015-03-12 2016-09-15 Beth Israel Deaconess Medical Center, Inc. Composés apparentés à atra améliorés pour le traitement de maladies prolifératives, de maladies auto-immunes et d'affections addictives
WO2016149021A1 (fr) 2015-03-13 2016-09-22 Life Technologies Corporation Procédés, compositions et kits pour la capture, la détection et la quantification de petit nra
CN107750279A (zh) 2015-03-16 2018-03-02 个人基因组诊断公司 核酸分析系统和方法
CN107429297A (zh) 2015-03-16 2017-12-01 简·探针公司 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物
CN107430646B (zh) 2015-03-17 2021-10-22 生物辐射实验室股份有限公司 检测基因组编辑
IL237852A0 (en) 2015-03-19 2016-03-24 Yeda Res & Dev Antibodies against amphigoline, medical preparations containing them and their use
WO2016154046A2 (fr) 2015-03-20 2016-09-29 Verdezyne, Inc. Procédés biologiques pour préparer de l'acide 3-hydroxypropionique
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US20180064748A1 (en) 2015-03-27 2018-03-08 Yeda Research And Development Co. Ltd. Methods of treating motor neuron diseases
TWI804917B (zh) 2015-03-27 2023-06-11 美商再生元醫藥公司 偵測生物污染物之組成物及方法
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
US10301660B2 (en) 2015-03-30 2019-05-28 Takara Bio Usa, Inc. Methods and compositions for repair of DNA ends by multiple enzymatic activities
AU2016242298A1 (en) 2015-03-31 2017-10-19 Yeda Research And Development Co. Ltd. Glutamate Oxaloacetate Transaminase 1 (GOT1), preparations and methods of generating same and uses thereof
WO2016157192A1 (fr) 2015-04-01 2016-10-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Extraits végétaux de crassifolium erodium l'her et leurs utilisations
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US10968185B2 (en) 2015-04-07 2021-04-06 Ela Pharma Ltd. Substituted thiazoles for preventing and/or treating cell or tissue necrosis
US11965216B2 (en) 2015-04-07 2024-04-23 Polyskope Labs Detection of one or more pathogens
WO2016162325A1 (fr) 2015-04-07 2016-10-13 Astrazeneca Ab Dérivés de 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2h)-ones substitués utilisés comme inhibiteurs de kinase
MX2017012610A (es) 2015-04-08 2018-03-16 Alnylam Pharmaceuticals Inc Composiciones y metodos para inhibir la expresion del gen lect2.
DK3901281T3 (da) 2015-04-10 2023-01-23 Spatial Transcriptomics Ab Rumligt adskilt, multipleks nukleinsyreanalyse af biologiske prøver
EP3081575A1 (fr) 2015-04-12 2016-10-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anticorps anti-plasmodium pour parasite
CA3219684A1 (fr) 2015-04-13 2016-10-13 Pfizer Inc. Anticorps anti-bcma, anticorps, anti-cd3 et anticorps bispecifiques se liant a bcma et a cd3
KR102528825B1 (ko) 2015-04-13 2023-05-08 화이자 인코포레이티드 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
PT3283499T (pt) 2015-04-15 2022-08-23 Biosearch Tech Inc Sondas de extintor dual
EA201792289A1 (ru) 2015-04-17 2018-04-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Способы обнаружения агглютинации и композиции для их осуществления
WO2016172606A1 (fr) 2015-04-23 2016-10-27 Baylor College Of Medicine Récepteur antigénique chimérique ciblant le cd5 pour une thérapie adoptive à base de cellules t
WO2016172204A1 (fr) 2015-04-24 2016-10-27 Becton, Dickinson And Company Détection multiplex de candidose vulvo-vaginale, de trichomonase et de vaginose bactérienne
CN107849603B (zh) 2015-04-24 2022-01-28 阿提拉生物系统公司 利用有限核苷酸组成的引物扩增
WO2016170447A1 (fr) 2015-04-24 2016-10-27 Rinat Neuroscience Corp. Transglutaminases microbiennes recombinantes
AU2016255725B2 (en) 2015-04-27 2021-09-23 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center EGR1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
US10988737B2 (en) 2015-04-28 2021-04-27 Universite De Strasbourg Clinical gene signature-based human cell culture model and uses thereof
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
BR112017023448A2 (pt) 2015-04-29 2018-07-31 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) composições anti-fitopatogênicas
US20190031759A1 (en) 2015-04-30 2019-01-31 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
CN108025088B (zh) 2015-05-04 2021-08-10 布里格姆及妇女医院股份有限公司 溶瘤性hsv1载体及其使用方法
WO2016178207A1 (fr) 2015-05-04 2016-11-10 Ramot At Tel-Aviv University Ltd. Procédés et kits pour fragmenter l'adn
CN108271386B (zh) 2015-05-06 2022-07-15 阿尔尼拉姆医药品有限公司 因子XII(哈格曼因子)(F12)、激肽释放酶B、血浆(夫列契因子)1(KLKB1)和激肽原1(KNG1)iRNA组合物及其使用方法
US20180161300A1 (en) 2015-05-11 2018-06-14 Yeda Research And Development Co., Ltd. Citrin inhibitors for the treatment of cancer
AU2016262494B2 (en) 2015-05-11 2019-11-07 Impossible Foods Inc. Expression constructs and methods of genetically engineering methylotrophic yeast
US10526588B2 (en) 2015-05-14 2020-01-07 Roche Sequencing Solutions, Inc. Polymerase variants and uses thereof
EP3294448A4 (fr) 2015-05-14 2018-12-12 Longhorn Vaccines and Diagnostics, LLC Procédés rapides pour l'extraction d'acides nucléiques provenant d'échantillons biologiques
US10978174B2 (en) 2015-05-14 2021-04-13 Life Technologies Corporation Barcode sequences, and related systems and methods
WO2016185471A1 (fr) 2015-05-17 2016-11-24 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Compositions et méthodes de traitement du cancer
AU2016265839A1 (en) 2015-05-18 2017-12-07 Csl Behring Gene Therapy, Inc. Methods of discriminating between HIV-1 and lentiviral vectors
WO2016185457A1 (fr) 2015-05-19 2016-11-24 Yeda Research And Development Co. Ltd. Méthodes pour favoriser la lymphagiogenèse
US10849985B2 (en) 2015-05-20 2020-12-01 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
PE20180670A1 (es) 2015-05-20 2018-04-19 Broad Inst Inc Neoantigenos compartidos
CA2986203A1 (fr) 2015-05-21 2016-11-24 Yeda Research And Development Co. Ltd. Populations bacteriennes pour favoriser la sante
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
WO2016196366A1 (fr) 2015-05-29 2016-12-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Extension de durée de vie réplicative dans des maladies de vieillissement prématuré à l'aide d'isoformes p53
WO2016193969A2 (fr) 2015-05-29 2016-12-08 Opko Biologics Ltd. Variantes de l'oxyntomoduline pégylée
WO2016196478A1 (fr) 2015-06-01 2016-12-08 St. Jude Children's Research Hospital Procédés et compositions pour les pronostics et/ou la gestion clinique de la maladie du greffon contre l'hôte et du rejet de greffe
EP3302053B1 (fr) 2015-06-02 2021-03-17 Monsanto Technology LLC Compositions et procédés pour l'administration d'un polynucléotide dans une plante
US10655136B2 (en) 2015-06-03 2020-05-19 Monsanto Technology Llc Methods and compositions for introducing nucleic acids into plants
WO2016197133A1 (fr) 2015-06-04 2016-12-08 Protiva Biotherapeutics, Inc. Administration d'agents thérapeutiques crispr avec des nanoparticules de lipide
US20180245074A1 (en) 2015-06-04 2018-08-30 Protiva Biotherapeutics, Inc. Treating hepatitis b virus infection using crispr
CN107787181A (zh) 2015-06-05 2018-03-09 国际水稻研究所 通过细胞质雄性不育水稻中更高的异交率提高杂交种子生产以及相关材料和方法
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
EP3653728B1 (fr) 2015-06-09 2023-02-01 Life Technologies Corporation Procédés, systèmes, compositions, kits, appareil et supports lisibles par ordinateur de marquage moléculaire
EP3307316A1 (fr) 2015-06-12 2018-04-18 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant du complément c5 et leurs procédés d'utilisation
BR112017026564B1 (pt) 2015-06-15 2022-05-03 4D Pharma Research Limited Células de bactéria, usos das mesmas, e composição
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
CN107847529B (zh) 2015-06-15 2022-05-03 4D制药研究有限公司 包含细菌菌株的组合物
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
CN108271354B (zh) 2015-06-15 2022-07-29 4D制药研究有限公司 包含细菌菌株的组合物
WO2016203476A1 (fr) 2015-06-18 2016-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés et compositions pour le diagnostic et le traitement d'un cancer urothélial
EP3310918B1 (fr) 2015-06-18 2020-08-05 Alnylam Pharmaceuticals, Inc. Agents polynucléotidiques ciblant l'hydroxyacide oxydase (glycolate oxydase, hao1) et procédés d'utilisation de ceux-ci
ES2917884T3 (es) 2015-06-18 2022-07-12 Yeda Res & Dev Protocolos de acondicionamiento y uso de los mismos para la regeneración de tejidos
CN115015552A (zh) 2015-06-19 2022-09-06 赛拉预测公司 用于预测早产的生物标志物对
ES2893616T3 (es) 2015-06-19 2022-02-09 Opko Biologics Ltd Factores de coagulación de acción prolongada y métodos para la producción de los mismos
CN114805576A (zh) 2015-06-24 2022-07-29 詹森药业有限公司 抗vista抗体和片段
MX2017016501A (es) 2015-06-26 2018-03-12 Dupont Nutrition Biosci Aps Aminopeptidasas para hidrolizados de proteinas.
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
GB201511470D0 (en) 2015-06-30 2015-08-12 Cellcall Kft HPV detection method
WO2017004579A1 (fr) 2015-07-01 2017-01-05 O'connor Colleen M Cellules présentatrices d'antigènes artificielles pour thérapie cellulaire adoptive contre le cancer
EP4116316A1 (fr) 2015-07-04 2023-01-11 Evaxion Biotech A/S Protéines et acides nucléiques utiles dans des vaccins ciblant pseudomonas aeruginosa
WO2017011286A1 (fr) 2015-07-10 2017-01-19 Alnylam Pharmaceuticals, Inc. Compositions d'arni de la sous-unité acide labile de la protéine se liant au facteur de croissance apparenté a l'insuline (igfals) et du facteur de croissance 1 apparenté a l'insuline (igf-1) et leurs procédés d'utilisation
WO2017011275A1 (fr) 2015-07-10 2017-01-19 Nersissian Aram M Compositions de protéine de facteur viii et méthodes de traitement de l'hémophilie a
ES2963038T3 (es) 2015-07-16 2024-03-25 Yeda Res & Dev Uso de células T de memoria central antitercero
WO2017009843A2 (fr) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions, articles de fabrication et procédés pour traiter le cancer
CA2992717A1 (fr) 2015-07-17 2017-01-26 President And Fellows Of Harvard College Procedes d'amplification de sequences d'acides nucleiques
EP3325494B1 (fr) 2015-07-19 2020-12-30 Yeda Research and Development Co., Ltd. Inhibiteurs séléctifs de na,k-atpase contenant des isoformes alpha2 et leur utilisation pour réduire la pression intraoculaire
EP3325634A4 (fr) 2015-07-21 2019-03-13 The Regents of The University of California Métabolisme du glucose comprenant une soupape de purge moléculaire
US10870111B2 (en) 2015-07-22 2020-12-22 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
CN108027203B (zh) 2015-07-22 2020-11-03 北卡罗来纳-查佩尔山大学 具有利用冰成核剂的冻结-解冻阀的流体装置和相关的操作和分析方法
MX2018000844A (es) 2015-07-22 2018-07-06 Phytopharma Int Ltd Composiciones ingeribles por abejas, procedimientos para el uso de las mismas para producir miel y miel producida de esta manera.
US11214829B2 (en) 2015-07-23 2022-01-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
AU2016297005A1 (en) 2015-07-23 2018-01-18 Merck Sharp & Dohme Corp. Genetic markers associated with response to CRTH2 receptor antagonists
EP3325010B1 (fr) 2015-07-23 2023-06-21 The Regents of The University of California Anticorps anti-facteur de coagulation xia et leurs utilisations
US10066229B2 (en) 2015-07-28 2018-09-04 Otonomy, Inc. Treatment using truncated Trk B and Trk C antagonists
CA2993652A1 (fr) 2015-07-28 2017-02-02 Caris Science, Inc. Oligonucleotides cibles
CN108350455A (zh) 2015-07-29 2018-07-31 阿布特斯生物制药公司 用于使b型肝炎病毒基因表达沉默的组合物和方法
ES2865024T3 (es) 2015-07-29 2021-10-14 Hadasit Med Res Service Producción a gran escala de células de epitelio pigmentario retiniano
JP2018528763A (ja) 2015-07-31 2018-10-04 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムの除去のためのペプチドおよび抗体
EP3124619B1 (fr) 2015-07-31 2019-03-06 Menicon Co., Ltd Réactifs, procédé et kit pour le diagnostic du glaucome de races canines
US10745680B2 (en) 2015-08-03 2020-08-18 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
US20180221393A1 (en) 2015-08-03 2018-08-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
WO2017024173A1 (fr) 2015-08-04 2017-02-09 The Regents Of The University Of Colorado Ensemble binaire multiplexé et suivi quantitatif de populations bactériennes
US20180237774A1 (en) 2015-08-04 2018-08-23 Yeda Research And Development Co. Ltd. Methods of screening for riboswitches and attenuators
ES2932823T3 (es) 2015-08-05 2023-01-26 Cell Cure Neurosciences Ltd Preparación de células del epitelio pigmentario de la retina
US11090337B2 (en) 2015-08-05 2021-08-17 Cell Cure Neurosciences Ltd Preparation of photoreceptors for the treatment of retinal diseases
EP3334840A1 (fr) 2015-08-10 2018-06-20 Stratos Genomics, Inc. Séquençage de molécule unique d'acide nucléique avec des complexes de chimiorécepteurs
EP3334449B1 (fr) 2015-08-10 2021-09-29 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Méthodes et compositions pharmaceutiques permettant d'améliorer la cicatrisation des plaies par cd24
US20180237790A1 (en) 2015-08-13 2018-08-23 Forrest Innovation Ltd. Formulations and compositions for delivery of nucleic acids to plant cells
CN106434873B (zh) 2015-08-13 2021-08-27 生捷科技控股公司 使核酸分子同步化的方法
SI3334454T1 (sl) 2015-08-14 2023-02-28 Zoetis Services Llc Sestave mycoplasma bovis
NZ739871A (en) 2015-08-19 2022-05-27 Pfizer Tissue factor pathway inhibitor antibodies and uses thereof
WO2017033188A1 (fr) 2015-08-24 2017-03-02 Yeda Research And Development Co. Ltd. Huile et biocarburant d'origine algale et leurs procédés de production
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
EP3344290A4 (fr) 2015-08-31 2019-02-27 Technovax, Inc. Vaccin à base de pseudoparticules virales (vlp) contre le virus syncytial respiratoire humain (hrsv)
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
CA2996873A1 (fr) 2015-09-02 2017-03-09 Alnylam Pharmaceuticals, Inc. Compositions d'arni ciblant le ligand de mort cellulaire programmee 1 (pd-l1) et leurs methodes d'utilisation
MX2018002723A (es) 2015-09-03 2018-08-15 Aileron Therapeutics Inc Macrociclicos peptidomimeticos y usos de los mismos.
US10765706B2 (en) 2015-09-03 2020-09-08 University Of South Florida Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
CN116334205A (zh) 2015-09-03 2023-06-27 诺华股份有限公司 预测细胞因子释放综合征的生物标志物
WO2017041002A1 (fr) 2015-09-04 2017-03-09 Blazar Bruce R Méthodes et compositions d'augmentation de la fonction suppressive des lymphocytes t régulateurs (tregs)
DK3328881T3 (da) 2015-09-08 2019-10-07 Theripion Inc Apoa-1 fusionspolypeptider og relaterede sammensætninger og fremgangsmåder
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11773455B2 (en) 2015-09-09 2023-10-03 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics infectious disease and other health conditions associated with antibiotic usage
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017042816A1 (fr) 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd. Ablation de cellules dendritiques dont le test est positif pour la perforine, dans le traitement du cancer
AU2016319189B2 (en) 2015-09-11 2022-07-07 Centre Hospitalier Universitaire De Montpellier Non-invasive methods for assessing genetic integrity of pluripotent stem cells
WO2017048620A1 (fr) 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Agents de polynucléotide ciblant un domaine de phospholipase de type patatine contenant 3 (pnpla3) et leurs procédés d'utilisation
TW201726140A (zh) 2015-09-17 2017-08-01 瑞典商阿斯特捷利康公司 治療癌症之新型生物標記及方法
US11078251B2 (en) 2015-09-18 2021-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) T cell receptors (TCR) and uses thereof for the diagnosis and treatment of diabetes
US10815536B2 (en) 2015-09-18 2020-10-27 The Trustees Of Columbia University In The City Of New York Virome capture sequencing platform, methods of designing and constructing and methods of using
EP3350349A4 (fr) 2015-09-18 2018-12-05 Siemens Healthcare Diagnostics Inc. Réactifs et méthodes d'analyse du vih
JP6956709B2 (ja) 2015-09-22 2021-11-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Ompgバリアント
ES2904513T3 (es) 2015-09-23 2022-04-05 Janssen Pharmaceutica Nv 1,4-Benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cáncer
WO2017050864A1 (fr) 2015-09-23 2017-03-30 Janssen Pharmaceutica Nv Nouveaux composés
EP3353214B1 (fr) 2015-09-25 2021-08-18 Universität Duisburg-Essen Agents d'inhibition kallikrein-8 pour utilisation dans la prévention ou le traitement de la maladie d'alzheimer
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
CN109477144B (zh) 2015-09-29 2022-12-09 国家儿童医院研究所 用于检测肝脏纤维化和对疗法的响应性的方法
US11884978B2 (en) 2015-09-30 2024-01-30 Immunexpress Pty Ltd Pathogen biomarkers and uses therefor
US11459573B2 (en) 2015-09-30 2022-10-04 Trustees Of Boston University Deadman and passcode microbial kill switches
CN108473472B (zh) 2015-10-02 2021-02-12 圣提内尔肿瘤学有限公司 作为p70s6激酶抑制剂的2-氨基喹唑啉衍生物
JP6847934B2 (ja) 2015-10-05 2021-03-24 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill アッセイを多重化する為のデコード方法並びに関連する流体デバイス、キット、及び固体支持体
WO2017060662A1 (fr) 2015-10-07 2017-04-13 The Secretary Of State For Health Procédé de préparation d'un témoin à utiliser dans un dépistage de virus pathogène
US10668068B2 (en) 2015-10-07 2020-06-02 The Research Foundation For The State University Of New York Treating cancer with drug combinations
CN105219767B (zh) 2015-10-09 2018-02-13 上海交通大学 大豆转化事件shzd32‑01及其应用方法
ES2796501T3 (es) 2015-10-10 2020-11-27 Guardant Health Inc Métodos y aplicaciones de la detección de fusión de genes en el análisis de ADN sin células
WO2017066719A2 (fr) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Agents spécifiques interférant avec hu
AU2016337408B2 (en) 2015-10-16 2022-11-03 Astrazeneca Ab Inducible modification of a cell genome
EP3362074B1 (fr) 2015-10-16 2023-08-09 President and Fellows of Harvard College Modulation de pd-1 des lymphocytes t régulateurs pour réguler les réponses immunitaires effectrices des lymphocytes t
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
BR112018007710A2 (pt) 2015-10-18 2018-10-23 Affymetrix Inc genotipagem multialélica de polimorfismos de nucleotídeo único e indels
AU2016342179B2 (en) 2015-10-20 2022-08-18 FUJIFILM Cellular Dynamics, Inc. Multi-lineage hematopoietic precursor cell production by genetic programming
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
WO2017070643A1 (fr) * 2015-10-22 2017-04-27 University Of Maryland, Baltimore Procédés d'extraction d'acides nucléiques de sang sec et leurs utilisations
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
NZ741404A (en) 2015-10-23 2024-03-22 Univ California Anti-il-2 antibodies and compositions and uses thereof
EP3365376A1 (fr) 2015-10-25 2018-08-29 Yeda Research and Development Co., Ltd. Anticorps ciblant la quiescine sulfhydryle oxydase (qsox1) et leurs utilisations
US20180312805A1 (en) 2015-10-26 2018-11-01 Cell Cure Neurosciences Ltd. Preparation of Retinal Pigment Epithelium Cells
US11090275B2 (en) 2015-10-27 2021-08-17 Jay Pharma Inc. Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer
WO2017075265A1 (fr) 2015-10-28 2017-05-04 The Broad Institute, Inc. Analyse multiplexée de constituants unicellulaires
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
WO2017075297A1 (fr) 2015-10-28 2017-05-04 The Broad Institute Inc. Système de distribution de réactif dynamique à rendement élevé
IL242380A0 (en) 2015-10-29 2016-02-01 Yeda Res & Dev A method for inducing the division of cardiomyocytes and treating heart diseases
US10865396B2 (en) 2015-10-29 2020-12-15 Temple University—Of the Commonwealth System of Higher Education Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta
AU2016343978A1 (en) 2015-10-29 2018-05-17 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids
MX2018005468A (es) 2015-10-30 2018-11-09 The Us Secretary Department Of Health And Man Services Terapia dirigida contra el cáncer.
TW202344686A (zh) 2015-10-30 2023-11-16 美國加利福尼亞大學董事會 從幹細胞產生t細胞之方法及使用該t細胞之免疫療法
US10704081B2 (en) 2015-10-30 2020-07-07 Exact Sciences Development Company, Llc Multiplex amplification detection assay
WO2017075559A1 (fr) 2015-10-30 2017-05-04 E. I. Du Pont De Nemours And Company Compositions inhibitrices de la dihydroorotate déshydrogénase efficaces en tant qu'herbicides
LT3370733T (lt) 2015-11-02 2021-10-25 Board Of Regents, The University Of Texas System Cd40 aktyvinimo ir imuninės kontrolės taškų blokados būdai
EP3370791A1 (fr) 2015-11-03 2018-09-12 Ariel-University Research and Development Company Ltd. Compositions destinées à la régénération et à la réparation de tissu nerveux
AU2016349897B2 (en) 2015-11-03 2021-11-04 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
CN108884159A (zh) 2015-11-07 2018-11-23 茂体外尔公司 用于癌症治疗的包含肿瘤抑制基因治疗和免疫检查点阻断的组合物
WO2017080979A1 (fr) 2015-11-09 2017-05-18 Astrazeneca Ab Dérivés de dihydroimidazopyrazinone utiles dans le traitement du cancer
WO2017080980A1 (fr) 2015-11-09 2017-05-18 Astrazeneca Ab Dérivés de dihydropyrrolopyrazinone utiles dans le traitement du cancer
JP6987068B2 (ja) 2015-11-09 2021-12-22 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia 癌マーカーおよび治療標的としてのグリピカン2
US11039588B2 (en) 2015-11-10 2021-06-22 Vilmorin & Cie Resistance to ToLCNDV in squash
EP3374524A4 (fr) 2015-11-11 2019-06-26 Ramot at Tel-Aviv University Ltd. Procédés de détection de la 5-hydroxyméthylcytosine et diagnostic du cancer
MA45287A (fr) 2015-11-20 2018-08-22 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
JP6685396B2 (ja) 2015-11-20 2020-04-22 シージーン アイエヌシー 標的分析物質に対するデータセットの補正方法
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
BR112018010946A2 (pt) 2015-11-30 2018-12-04 Kadimastem Ltd método para enriquecimento de células endócrinas pancreáticas, população enriquecida de células endócrinas pancreáticas, método de tratamento de diabetes e método de preparação de células beta de produção de insulina
EP3176183A1 (fr) 2015-12-02 2017-06-07 Yeda Research and Development Co. Ltd Compositions et procédés pour traiter un cancer non résistant à un inhibiteur de la tyrosine kinase (tki)
US20180371551A1 (en) 2015-12-03 2018-12-27 Agios Pharmaceuticals, Inc. Mat2a inhibitors for treating mtap null cancer
CN108368151B (zh) 2015-12-07 2022-11-15 生物辐射实验室股份有限公司 二聚逆转录酶
BR112018011639A2 (pt) 2015-12-08 2018-11-27 Biomatrica Inc redução de taxa de sedimentação de eritrócitos
EP3387147A1 (fr) 2015-12-09 2018-10-17 Life Technologies Corporation Détection et détermination quantitative de molécules d'acide nucléique associées à une surface
WO2017100542A1 (fr) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Compositions d'arni chaperon (scap) de la protéine srebp (sterol regulatory element binding protein), et procédés d'utilisation associés
EP3387107B1 (fr) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Système et procédés de fermeture étanche de tubes pour l'amplification d'acide nucléique
US11213609B2 (en) 2015-12-16 2022-01-04 Ramot At Tel-Aviv University Ltd. Particles comprising decellularized omentum
CN108603224B (zh) 2015-12-16 2022-06-28 富鲁达公司 高水平多路复用扩增
EP3181699A1 (fr) 2015-12-17 2017-06-21 Oniris Micro-arn comme biomarqueurs prédictifs des diabètes de type 1
WO2017106447A1 (fr) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Locus génétiques associés à des phénotypes de croissance reproductive chez le soja et procédés d'utilisation
WO2017106767A1 (fr) 2015-12-18 2017-06-22 The Scripps Research Institute Production de nucléotides non naturels par l'utilisation d'un système crispr/cas9
EP3393524B1 (fr) 2015-12-22 2022-04-06 The Regents of The University of Colorado, A Body Corporate Protection d'arn de la dégradation à l'aide d'arn viraux modifiés
EP3998345A1 (fr) 2015-12-24 2022-05-18 ImmuneXpress Pty Ltd Biomarqueurs de triage et leurs utilisations
IL260331B1 (en) 2015-12-28 2024-06-01 B G Negev Technologies And Applications Ltd At Ben Gurion Univ Compounds and methods for the treatment of amyotrophic lateral sclerosis
EP3397764A4 (fr) 2015-12-30 2019-05-22 Bio-Rad Laboratories, Inc. Quantification numérique de protéines
CN108603193B (zh) 2015-12-30 2022-07-22 生物辐射实验室股份有限公司 分裂循环和tape扩增
WO2017120216A2 (fr) 2016-01-04 2017-07-13 Gen-Probe Incorporated Procédés et compositions de détection l'espèce candida
AU2017204950A1 (en) 2016-01-06 2018-08-16 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
RU2766000C2 (ru) 2016-01-08 2022-02-07 АльтруБио Инк. Четырехвалентные антитела к psgl-1 и их применения
WO2017120531A1 (fr) 2016-01-08 2017-07-13 Bio-Rad Laboratories, Inc. Résolution de multiples particules par gouttelette
US20190178888A1 (en) 2016-01-11 2019-06-13 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
US10894985B2 (en) 2016-01-12 2021-01-19 Sitokine Limited Methods for predicting response to treatment
WO2017122039A1 (fr) 2016-01-13 2017-07-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la réponse thérapeutique dans le cancer pancréatique
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
WO2017121836A1 (fr) 2016-01-15 2017-07-20 Thermo Fisher Scientific Baltics Uab Mutants d'adn polymérases thermophiles
CN108463559A (zh) 2016-01-15 2018-08-28 文塔纳医疗系统公司 肿瘤的深度测序概况分析
CN108431226A (zh) 2016-01-15 2018-08-21 阿斯利康(瑞典)有限公司 基因修饰测定
EP3402902B1 (fr) 2016-01-15 2021-10-27 Massachusetts Institute Of Technology Réseaux semi-perméables pour analyser des systèmes biologiques et procédé pour les utiliser
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
CN109219618B (zh) 2016-01-21 2022-08-09 辉瑞大药厂 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途
CN109068605B (zh) 2016-01-21 2022-11-11 以色列国家农业和农村发展农业研究组织沃尔坎尼中心 单性结实植物及其产生方法
WO2017127727A1 (fr) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Antibiogramme rapide effectué au moyen de procédés de détection directe à haute sensibilité
UA125252C2 (uk) 2016-01-21 2022-02-09 Пфайзер Інк. Химерний антигенний рецептор, що націлений на варіант iii рецептора епідермального фактора росту
US10982286B2 (en) 2016-01-22 2021-04-20 Mayo Foundation For Medical Education And Research Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
IL243839B (en) 2016-01-28 2018-01-31 Sp Nano Ltd Conductive wires
IL243838A (en) 2016-01-28 2017-07-31 Sp Nano Ltd The composition containing sp1 protein and carbon nanoparticles and its uses
EP3408649B1 (fr) 2016-01-29 2023-06-14 Vanderbilt University Interférométrie à fonction de réponse en solution libre
EP3407974A4 (fr) 2016-01-29 2019-08-28 The Regents Of The University Of Michigan Analogues d'amlexanox
WO2017130205A1 (fr) 2016-01-31 2017-08-03 Hadasit Medical Research Services And Development Ltd. Populations de cellules souches pluripotentes ayant une composition de chromosomes sexuels non identiques et leurs utilisations
SG11201806398YA (en) 2016-02-01 2018-08-30 Bioverativ Therapeutics Inc Optimized factor viii genes
EP3199642A1 (fr) 2016-02-01 2017-08-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Sélection de plantes à l'aide de séquençage haut débit
EP3411390A1 (fr) 2016-02-04 2018-12-12 Yeda Research and Development Co. Ltd Peptides et leur utilisation dans le traitement de maladies, troubles ou affections associés à un p53 mutant
EP3411710A1 (fr) 2016-02-05 2018-12-12 The Broad Institute Inc. Isolement et traitement de cible multiplexés à étapes multiples à partir de populations hétérogènes
EP3411819A4 (fr) 2016-02-05 2019-10-23 Seegene, Inc. Procédé de réduction de niveau de bruit d'ensemble de données pour un analyte cible
BR112018016057A2 (pt) 2016-02-05 2019-01-29 Pioneer Hi Bred Int métodos para selecionar uma planta de soja ou um germoplasma de soja com resistência aprimorada a infecção por podridão parda da haste e kit
WO2017138986A1 (fr) 2016-02-09 2017-08-17 Cibus Us Llc Procédés et compositions permettant d'améliorer l'efficacité de modifications génétiques ciblées en utilisant la réparation de gène médiée par des oligonucléotides
US10036011B2 (en) 2016-02-11 2018-07-31 Qiagen Waltham, Inc. Scavenger compounds for improved sequencing-by-synthesis
US10337050B2 (en) 2016-02-11 2019-07-02 Qiagen Sciences, Llc Polyphenolic additives in sequencing by synthesis
AR107591A1 (es) 2016-02-11 2018-05-16 Pioneer Hi Bred Int Qtl asociados con la resistencia al vuelco del poroto de soja y métodos para identificarla
TWI756204B (zh) 2016-02-12 2022-03-01 比利時商楊森製藥公司 抗vista抗體及片段、其用途及鑑定其之方法
EP3414346B1 (fr) 2016-02-14 2019-11-13 Yeda Research and Development Co. Ltd. Diagnostic basé sur le microbiome, prédiction et traitement de l'obésité de rechute
US20190046497A1 (en) 2016-02-14 2019-02-14 Yeda Research And Development Co., Ltd. Methods of modulating protein exocytosis and uses of same in therapy
JP2019508422A (ja) 2016-02-16 2019-03-28 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドYissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. シアノバクテリアおよび植物の増殖を阻害するための非タンパク質性フェニルアラニン類似体
AU2017219859A1 (en) 2016-02-16 2018-08-09 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
US20190160098A1 (en) 2016-02-16 2019-05-30 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptors and methods of use thereof
US10946084B2 (en) 2016-02-22 2021-03-16 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
US11053476B2 (en) 2016-02-23 2021-07-06 Exostem Biotec Ltd. Generation of cancer stem cells and use thereof
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
MX2018009216A (es) 2016-02-25 2018-11-09 Dupont Nutrition Biosci Aps Metodo para producir un hidrolizado de proteina empleando una tripeptidil peptidasa de aspergillus fumigatus.
WO2017148862A1 (fr) 2016-02-29 2017-09-08 Genia Technologies, Inc. Variants de polymérase
US10590480B2 (en) 2016-02-29 2020-03-17 Roche Sequencing Solutions, Inc. Polymerase variants
CN108699539B (zh) 2016-02-29 2022-11-18 吉尼亚科技公司 外切核酸酶缺陷的聚合酶
WO2017148860A1 (fr) 2016-02-29 2017-09-08 Genia Technologies, Inc. Complexes polymérase-matrice pour le séquençage de nanopores
ES2903280T3 (es) 2016-03-01 2022-03-31 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Anticuerpos específicos del receptor de poliovirus humano (RPH)
EP3907292A1 (fr) 2016-03-03 2021-11-10 Memed Diagnostics Ltd. Analyse d'arn pour diagnostiquer un type d'infection
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
JP6441536B2 (ja) 2016-03-04 2018-12-19 フォーディー ファーマ ピーエルシー4D Pharma Plc 細菌株を含む組成物
US11447782B2 (en) 2016-03-04 2022-09-20 Danisco Us Inc. Engineered ribosomal promoters for protein production in microorganisms
US20190216891A1 (en) 2016-03-06 2019-07-18 Yeda Research And Development Co., Ltd. Method for modulating myelination
WO2017155858A1 (fr) 2016-03-07 2017-09-14 Insilixa, Inc. Identification de séquence d'acide nucléique à l'aide d'une extension de base unique cyclique en phase solide
WO2017156126A1 (fr) 2016-03-10 2017-09-14 Pioneer Hi-Bred International, Inc. Amplification en chaîne par polymérase médiée par la lumière et système de détection de produit et procédés d'utilisation
ES2969020T3 (es) 2016-03-11 2024-05-16 Hoffmann La Roche Composiciones y procedimientos para la detección del virus de Zika
US9771623B1 (en) 2016-03-15 2017-09-26 The Board Of Regents Of The University Of Texas System Molecular typing system for flavivirus diagnostics
AU2017234163B2 (en) 2016-03-15 2023-01-19 Mersana Therapeutics, Inc. NaPi2b-targeted antibody-drug conjugates and methods of use thereof
CN109476756B (zh) 2016-03-15 2022-05-31 埃泰美德(香港)有限公司 一种多特异性Fab融合蛋白及其用途
IL244649A0 (en) 2016-03-17 2016-06-30 Yeda Res & Dev Methods for the isolation of barrel-like proteases and the identification of peptides that are cleaved by Alidan
EP3430137A4 (fr) 2016-03-18 2019-11-06 Caris Science, Inc. Sondes oligonucléotidiques et utilisations de celles-ci
US10995350B2 (en) 2016-03-23 2021-05-04 MOgene Green Chemicals LLC Purine alkaloid-producing microorganisms and methods of making and using the same
WO2017164741A2 (fr) 2016-03-24 2017-09-28 Stichting Sanquin Bloedvoorziening Détection d'acide nucléique du virus zika
CN115969854A (zh) 2016-03-24 2023-04-18 科瑞华生物技术有限公司 用tg02治疗癌症
JP7086855B2 (ja) 2016-03-28 2022-06-20 エヌキャン ジェノミクス, インコーポレイテッド 連結された二重鎖標的捕捉
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
BR112018069776A2 (pt) 2016-03-29 2019-02-05 Janssen Biotech Inc tratamento de psoríase com intervalo de dosagem aumentado de anticorpos anti-il-12 e/ou anti-il-23
EP3436049B1 (fr) 2016-03-31 2022-01-12 Baylor Research Institute Protéine 8 de type angiopoïétine (angptl8)
CN109310700A (zh) 2016-04-04 2019-02-05 希诺皮亚生物科学公司 使用曲匹地尔治疗锥体外系综合征
AU2017248219B2 (en) 2016-04-06 2023-09-07 Life Technologies Corporation Compositions, methods, and kits for synthesis and detection of nucleic acids
US10551384B2 (en) 2016-04-07 2020-02-04 Rutgers, The State University Of New Jersey MTOR kinase mutations and methods of use thereof
EP3442719B1 (fr) 2016-04-11 2021-09-01 APDN (B.V.I.) Inc. Procédé de marquage de produits cellulosiques
US10421785B2 (en) 2016-04-11 2019-09-24 Bar-Ilan University Delta receptor agonist peptides and use thereof
US11162945B2 (en) 2016-04-11 2021-11-02 Board Of Regents, The University Of Texas System Methods and compositions for detecting single T cell receptor affinity and sequence
UA123168C2 (uk) 2016-04-12 2021-02-24 Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган Деструктори білка вет
EP3442326A1 (fr) 2016-04-13 2019-02-20 Altria Client Services LLC Plants de tabac présentant une photosynthèse modifiée et leurs procédés de fabrication et d'utilisation
WO2017178587A1 (fr) 2016-04-14 2017-10-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de détection universelle et quantification d'adnr de mycoplasma (mollicutes) 16s par réaction en chaîne de la polymérase quantitative en amplifiant un fragment de 1,5 kilobase
WO2017180745A1 (fr) 2016-04-14 2017-10-19 T2 Biosystems, Inc. Procédés et systèmes d'amplification dans des échantillons complexes
BR112018071153A2 (pt) 2016-04-15 2019-04-16 Immunext, Inc. anticorpos anti-vista humano e uso dos mesmos
WO2017181143A1 (fr) 2016-04-15 2017-10-19 Generon (Shanghai) Corporation, Ltd. Utilisation d'il-22 pour le traitement de l'entérocolite nécrosante
MA45295A (fr) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
US10125135B2 (en) 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2017182981A1 (fr) 2016-04-20 2017-10-26 Washington University Agoniste de ppar ou agoniste de lxr à utiliser pour traiter le lupus érythémateux systémique par modulation de l'activité lap
WO2017182495A1 (fr) 2016-04-20 2017-10-26 Astrazeneca Ab Dérivés d'indazole qui régulent négativement le récepteur d'œstrogène et possèdent une activité anticancéreuse
AU2017257330A1 (en) 2016-04-27 2018-10-18 Pfizer Inc. Anti-IL-33 antibodies, compositions, methods and uses thereof
DE202017007130U1 (de) 2016-04-27 2019-08-29 Gen-Probe Inc. Lysereagenz für Blutzellen
US10781481B2 (en) 2016-04-27 2020-09-22 Bio-Rad Laboratories, Inc. miRNA transcriptome methods and compositions
US20190119364A1 (en) 2016-04-29 2019-04-25 The Regents Of The University Of Colorado, A Body Corporate Compounds and compositions useful for treating metabolic syndrome, and methods using same
US10829553B2 (en) 2016-04-29 2020-11-10 Pfizer Inc. Interferon beta antibodies and uses thereof
CN109715791B (zh) 2016-05-03 2023-07-14 丹尼斯科美国公司 蛋白酶变体及其用途
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
CN116064796A (zh) 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
WO2017193097A1 (fr) 2016-05-06 2017-11-09 Girihlet Inc. Procédés et compositions permettant de déterminer des appariements de chaînes tcr et bcr spécifiques
EP3455351B1 (fr) 2016-05-12 2022-08-24 DSM IP Assets B.V. Procédé destiné à augmenter la production d'acides gras polyinsaturés oméga 3 dans des micro-algues
CA3017672A1 (fr) 2016-05-12 2017-11-16 Pioneer Hi-Bred International, Inc. Procedes pour genotypage regroupe simultane
EP3458612B1 (fr) 2016-05-17 2023-11-15 Genecentric Therapeutics, Inc. Procédés pour sous-typage d'adénocarcinome pulmonaire
CN109863251B (zh) 2016-05-17 2022-11-18 基因中心治疗公司 对肺鳞状细胞癌亚型分型的方法
WO2017201315A1 (fr) 2016-05-18 2017-11-23 Roche Sequencing Solutions, Inc. Amplification pcr quantitative en temps réel à l'aide d'un dispositif basé sur l'électromouillage
CN109475581A (zh) 2016-05-22 2019-03-15 耶达研究及发展有限公司 为了移植及诱导耐受性而使用肺细胞的方法
EP3464630A1 (fr) 2016-05-23 2019-04-10 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Méthodes de diagnostic du cancer à l'aide d'antigènes testiculaires du cancer
WO2017205686A1 (fr) 2016-05-25 2017-11-30 Caris Science, Inc. Sondes oligonucléotidiques et utilisations de celles-ci
JP7178264B2 (ja) 2016-05-25 2022-11-25 ソーク インスティチュート フォー バイオロジカル スタディーズ オルガノイド作製および疾患モデル化のための組成物および方法
IL245861A0 (en) 2016-05-25 2016-09-04 Yeda Res & Dev Use of substances to treat drug-resistant tumors
GB2568608B (en) 2016-05-27 2022-10-12 Personalis Inc Personalized genetic testing
US20200282032A1 (en) 2016-05-27 2020-09-10 Etubics Corporation Neoepitope vaccine compositions and methods of use thereof
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
CN109154023B (zh) 2016-05-27 2022-09-20 豪夫迈·罗氏有限公司 用于检测阴道毛滴虫的组合物和方法
EP3464642A4 (fr) 2016-05-31 2020-02-19 The Regents of the University of California Procédés d'évaluation, de surveillance et de modulation du processus de vieillissement
EP3465506B1 (fr) 2016-06-01 2024-04-03 Life Technologies Corporation Procédés et systèmes destinés à la conception de panneau génétique
US11098360B2 (en) 2016-06-01 2021-08-24 Roche Sequencing Solutions, Inc. Immuno-PETE
WO2017205957A1 (fr) 2016-06-01 2017-12-07 9087-4405 Quebec Inc. Système d'accès à distance et procédé de gestion d'agents pathogènes de plantes
WO2017208247A1 (fr) 2016-06-02 2017-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Essai pour l'élimination de résidus de méthyle-cytosine de l'adn
US10036024B2 (en) 2016-06-03 2018-07-31 Purdue Research Foundation siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
US10584363B2 (en) * 2016-06-03 2020-03-10 Takara Bio Usa, Inc. Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
WO2017214068A1 (fr) 2016-06-05 2017-12-14 Berg Llc Systèmes et procédés de stratification de patient et identification de biomarqueurs potentiels
WO2017212476A1 (fr) 2016-06-05 2017-12-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Nouvelles molécules destinées au traitement de l'inflammation
AU2017277304B2 (en) 2016-06-07 2023-07-20 Cepheid Thermostable polymerase inhibitor compositions and methods
CN109906275B (zh) 2016-06-08 2023-05-12 爱荷华大学研究基金会 检测心血管疾病易感性的组合物和方法
WO2017212494A1 (fr) 2016-06-09 2017-12-14 Opko Biologics Ltd. Formulation d'oxyntomoduline à action prolongée, et procédés de production et procédés d'administration de cette dernière
JP2019518028A (ja) 2016-06-10 2019-06-27 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. 補体成分C5iRNA組成物及び発作性夜間血色素尿症(PNH)を処置するためのその使用方法
US10508312B2 (en) 2016-06-10 2019-12-17 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
CA2932910A1 (fr) 2016-06-14 2017-12-14 Entos Pharmaceuticals Inc. Methodes de diagnostic et de traitement de cancer metastatique
US20170356025A1 (en) 2016-06-14 2017-12-14 Roche Molecular Systems, Inc. Internal control probes for improving pcr assay performance
EP3472349A1 (fr) 2016-06-16 2019-04-24 Life Technologies Corporation Nouvelles compositions, procédés et kits permettant de détecter des micro-organismes
EP3257951A3 (fr) 2016-06-17 2018-03-14 AdvaTect Diagnostics, LLC Procédés et compositions pour identifier et quantifier l'adn fongique
WO2017221225A1 (fr) 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Criblage de la résistance à la chimiothérapie dans des cellules haploïdes humaines
EP3260552A1 (fr) 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Procédés et kits comprenant des signatures génétiques pour la stratification des patients souffrant de cancer du sein
JP7075900B2 (ja) 2016-06-20 2022-05-26 ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ 緑藻重炭酸輸送体およびその用途
IL246378A0 (en) 2016-06-21 2016-11-30 Technion Res & Dev Foundation A hybrid matrix of polymers that adhere to the mucosa and a lipidic drug release system for the treatment of oral cancer
AR108853A1 (es) 2016-06-22 2018-10-03 Univ North Carolina State Método para aumentar la eficacia en el uso de nitrógeno y/o la eficiencia en la utilización del nitrógeno en las plantas
WO2017223528A1 (fr) 2016-06-24 2017-12-28 The Scripps Research Institute Nouveau transporteur de nucléoside triphosphate et ses utilisations
DK3264087T3 (da) 2016-06-27 2020-07-20 Chimera Biotec Gmbh Fremgangsmåde og indretning til kvantificering af målmolekyler
US11155857B2 (en) 2016-06-27 2021-10-26 Dana-Farber Cancer Institute, Inc. Methods for measuring RNA translation rates
EP3475414A1 (fr) 2016-06-27 2019-05-01 Yeda Research and Development Co. Ltd Cellules veto générées à partir de lymphocytes t mémoire
CN110291402B (zh) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 鉴定肽表位的方法、结合此类表位的分子和相关用途
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
MX2018016389A (es) 2016-06-30 2019-08-16 Arbutus Biopharma Corp Composiciones y metodos para suministro de arn mensajero.
EP3479101B1 (fr) 2016-06-30 2023-12-13 Seegene, Inc. Appareil et procede d'amplification d'acide nucléique
JP2019527052A (ja) 2016-06-30 2019-09-26 クーンル アグロシステムズ,インコーポレイテッド 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品
EP3478325A4 (fr) 2016-07-01 2020-01-15 Research Development Foundation Élimination de cellules proliférantes de greffons dérivés de cellules souches
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
US11396678B2 (en) 2016-07-06 2022-07-26 The Regent Of The University Of California Breast and ovarian cancer methylation markers and uses thereof
WO2018009707A1 (fr) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Marqueurs de méthylation spécifiques d'une tumeur solide et utilisations de ces marqueurs
EP4141448A1 (fr) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Signatures protéiques permettant de faire la distinction entre des infections bactériennes et virales
EP4184167A1 (fr) 2016-07-10 2023-05-24 MeMed Diagnostics Ltd. Diagnostic précoce d'infections
AU2017296354A1 (en) 2016-07-11 2019-01-24 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Fusion proteins with extended serum half life
US20200080050A1 (en) 2016-07-11 2020-03-12 Yaakov Nahmias Systems and methods for growing cells in vitro
IL246722A0 (en) 2016-07-11 2016-09-29 Yeda Res & Dev Combined treatment to increase endogenous synthesis of nitric oxide
PT3481855T (pt) 2016-07-11 2023-11-27 Opko Biologics Ltd Fator vii de coagulação de ação prolongada e métodos de produção do mesmo
US20190224244A1 (en) 2016-07-11 2019-07-25 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
WO2018013509A1 (fr) 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions et méthodes pour diagnostiquer et traiter des arythmies
EP3485038B1 (fr) 2016-07-12 2020-12-23 H. Hoffnabb-La Roche Ag Enrichissement de cible d'extension d'amorce
US10676734B2 (en) 2016-07-12 2020-06-09 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
TW201821093A (zh) 2016-07-13 2018-06-16 英商4D製藥有限公司 包含細菌菌株之組合物
WO2018013883A1 (fr) 2016-07-14 2018-01-18 Caprion Proteomics Inc. Biomarqueurs d'une infection par la tuberculose latente
US20190177421A1 (en) 2016-07-15 2019-06-13 Poseida Therapeutics, Inc. Chimeric antigen receptors and methods for use
US20190328784A1 (en) 2016-07-15 2019-10-31 Poseida Therapeutics, Inc. Chimeric antigen receptors (cars) specific for muc1 and methods for their use
WO2018015881A1 (fr) 2016-07-18 2018-01-25 Ramot At Tel-Aviv University Ltd. Plate-forme modulaire pour thérapie ciblée
CA3029838A1 (fr) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Molecules temoins d'acides nucleiques provenant d'organismes non humains
CN109642228B (zh) 2016-07-19 2022-09-13 精密科学发展有限责任公司 甲基化对照dna
US11460405B2 (en) 2016-07-21 2022-10-04 Takara Bio Usa, Inc. Multi-Z imaging and dispensing with multi-well devices
CN117822128A (zh) 2016-07-22 2024-04-05 俄勒冈健康与科学大学 单细胞全基因组文库及制备其的组合索引方法
WO2018020489A1 (fr) 2016-07-24 2018-02-01 Yeda Research And Development Co. Ltd. Méthodes et kits pour analyser des fragments de liaison à l'adn liés à l'adn
TW201815789A (zh) 2016-07-25 2018-05-01 瑞典商阿斯特捷利康公司 化合物
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
CA3031994A1 (fr) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Procedes d'evaluation de la presence ou de l'absence d'un virus competent pour la replication
CN109642253A (zh) 2016-08-02 2019-04-16 豪夫迈·罗氏有限公司 用于提高核酸的扩增和检测/定量的效率的辅助寡核苷酸
EP3279337A1 (fr) 2016-08-04 2018-02-07 Servizo Galego de Saúde (SERGAS) Utilisation de sondes courtes entre 8 et 9 nucléotides dans des biotests multiplex
CN109642219B (zh) 2016-08-05 2021-02-26 生物辐射实验室股份有限公司 第二链引导
EP3497231B1 (fr) 2016-08-08 2023-10-04 Technology Innovation Momentum Fund (Israel) Limited Partnership Systèmes bactériens servant à analyser des polypeptides ubiquitinylés
WO2018029690A1 (fr) 2016-08-10 2018-02-15 Memed Diagnostics Ltd. Système et procédé d'analyse de données biologiques
WO2018029693A1 (fr) 2016-08-10 2018-02-15 Ramot At Tel-Aviv University Ltd. Analyse de l'état de méthylation et du nombre de copies
US20190218623A1 (en) 2016-08-10 2019-07-18 Institut Pasteur Methods and reagents for detecting piperaquine-resistant plasmodium falciparum malaria
JP7014449B2 (ja) 2016-08-14 2022-02-01 ラモット アット テル アビブ ユニバーシティ, リミテッド 神経障害を処置するための間葉系細胞由来エキソソーム
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
WO2018035429A1 (fr) 2016-08-18 2018-02-22 Wisconsin Alumni Research Foundation Peptides qui inhibent l'activation de syndécane-1 de vla-4 et de l'igf-1r
CN110506127B (zh) 2016-08-24 2024-01-12 维拉科特Sd公司 基因组标签预测前列腺癌患者对术后放射疗法应答性的用途
WO2018037416A1 (fr) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Procédés et compositions pour le traitement de maladies auto-immunes
EP3504342A1 (fr) 2016-08-26 2019-07-03 Life Technologies Corporation Commandes d'extraction et d'amplification d'acides nucléiques et procédés d'utilisation associés
CA3035308A1 (fr) * 2016-08-31 2018-03-08 Taro Pharmaceutical Industries, Ltd. Formulations topiques de fenoldopam pour le traitement de troubles cutanes
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
KR20240038151A (ko) 2016-09-02 2024-03-22 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 간세포 암종 검출
WO2018047154A1 (fr) 2016-09-07 2018-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anticorps anti-nkp46 et leur utilisation thérapeutique
WO2018049261A1 (fr) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Virus oncolytique exprimant des modulateurs du point de contrôle immunitaire
WO2018049362A1 (fr) 2016-09-12 2018-03-15 Massachusetts Institute Of Technology Detecteur de transcription pour des acides biliaires dans bacteroides thetaiotaomicron
CA3036841A1 (fr) 2016-09-13 2018-03-22 The Regents Of The University Of Michigan 1,4-diazepines fusionnees en tant qu'agents de degradation de proteines bet
CN110062759B (zh) 2016-09-13 2022-05-24 密执安大学评议会 作为bet蛋白降解剂的稠合的1,4-氧氮杂䓬
WO2018051347A1 (fr) 2016-09-14 2018-03-22 Yeda Research And Development Co. Ltd. Crisp-seq, procédé intégré pour séquençage massivement parallèle d'arn unicellulaire et criblages regroupés par crispr
ES2933176T3 (es) 2016-09-15 2023-02-02 Hoffmann La Roche Procedimientos para realizar PCR ultrarrápida multiplexada
FR3056227B1 (fr) 2016-09-19 2021-01-01 Immunosearch Methode d'evaluation du potentiel d'irritation oculaire de produits chimiques
WO2018051355A1 (fr) 2016-09-19 2018-03-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Tamoxifène ou tamoxifène en combinaison avec de l'arginine/citrulline destinés à être utilisés dans le traitement de la dystrophie musculaire
US11136409B2 (en) 2016-09-20 2021-10-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
WO2018054970A2 (fr) 2016-09-22 2018-03-29 F. Hoffmann-La Roche Ag Variants de la polymérase pol6
GB201616116D0 (en) 2016-09-22 2016-11-09 Astrazeneca Ab Use of c-Met inhibitors to treat cancers harbouring MET mutations
WO2018057928A1 (fr) 2016-09-23 2018-03-29 Grail, Inc. Procédés de préparation et d'analyse de bibliothèques de séquençage d'acide nucléique acellulaire
CN109890983A (zh) 2016-09-23 2019-06-14 生命技术公司 用于评估免疫应答的组合物和方法
WO2018060998A1 (fr) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Méthodes de pronostic et de traitement
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
CN109923203A (zh) 2016-09-30 2019-06-21 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
MX2019003703A (es) 2016-09-30 2020-08-13 Janssen Biotech Inc Método seguro y eficaz para tratar la psoriasis con el anticuerpo específico anti-il23.
CN110035662B (zh) 2016-09-30 2022-09-30 美国陶氏益农公司 二元杀虫cry毒素
MX2019003689A (es) 2016-10-05 2019-08-22 Fujifilm Cellular Dynamics Inc Metodos para diferenciacion dirigida de citoblastos pluripotentes a células inminitarias homocigotas de antígenos leucocitarios humanos.
CN110050061A (zh) 2016-10-05 2019-07-23 富士胶片细胞动力公司 从具有MeCP2破坏的诱导多能干细胞生成成熟谱系
WO2018065985A1 (fr) 2016-10-06 2018-04-12 Moran Bercovici Dispositif et procédé de focalisation isotachophorétique de grands volumes d'échantillons
CN110267980A (zh) 2016-10-06 2019-09-20 波赛达治疗公司 诱导型胱天蛋白酶及使用方法
US11266174B2 (en) 2016-10-07 2022-03-08 Altria Client Services Llc Tobacco plants having increased nitrogen efficiency and methods of using such plants
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
WO2018071522A1 (fr) 2016-10-11 2018-04-19 Life Technologies Corporation Amplification rapide d'acides nucléiques
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
IL248468A0 (en) 2016-10-13 2017-01-31 Technion Res & Dev Foundation Use of caspase-3 inhibitors and caspase-3 activators in the preparation of medical preparations for cancer treatment and wound healing
WO2018071814A1 (fr) 2016-10-14 2018-04-19 The Trustees Of Columbia University In The City Of New York Procédés de traitement d'un trouble d'abus d'alcool
IL248385A0 (en) 2016-10-18 2017-02-01 Yeda Res & Dev Treatment of circadian rhythm disorder
AU2017346854B2 (en) 2016-10-19 2024-05-23 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
PT3640251T (pt) 2016-10-24 2022-02-22 Astrazeneca Ab Derivados de 6,7,8,9-tetra-hidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento do cancro
WO2018081535A2 (fr) 2016-10-28 2018-05-03 Massachusetts Institute Of Technology Ingénierie dynamique du génome
CA3042694A1 (fr) 2016-11-02 2018-05-11 David Evans Poxvirus chimeriques synthetiques
WO2018085862A2 (fr) 2016-11-07 2018-05-11 Grail, Inc. Procédés d'identification de signatures mutationnelles somatiques pour la détection précoce du cancer
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
US11162129B2 (en) 2016-11-09 2021-11-02 IsoPlexis Corporation Photoprotective mixtures as imaging reagents in sequencing-by-synthesis
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
EP3538651A1 (fr) 2016-11-10 2019-09-18 Yeda Research and Development Co., Ltd. Phosphotriestérases destinés au traitement ou à prévention des dommages associés à l'exposition aux organophosphates
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質minionに関連する組成物、方法、および治療上の使用
WO2018093752A1 (fr) 2016-11-15 2018-05-24 Danisco Us Inc. Champignons filamenteux à production améliorée de protéines
JP2020502261A (ja) 2016-11-16 2020-01-23 ヤンセン バイオテツク,インコーポレーテツド 抗il23特異的抗体で乾癬を治療する方法
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
WO2018094008A1 (fr) 2016-11-21 2018-05-24 Fmc Corporation Inhibiteurs de la cellulose synthase efficaces en tant qu'herbicides
CN110100011A (zh) 2016-11-21 2019-08-06 诺维信公司 Dna分子的酵母细胞提取物辅助构建
WO2018094171A1 (fr) 2016-11-21 2018-05-24 Gen-Probe Incorporated Compositions et méthodes pour détecter ou quantifier le virus de l'hépatite b
WO2018098241A1 (fr) 2016-11-22 2018-05-31 University Of Rochester Méthodes d'évaluation du risque de cancer de la prostate récurrent
TW202313978A (zh) 2016-11-23 2023-04-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
CN110234765A (zh) 2016-11-28 2019-09-13 耶达研究及发展有限公司 分离的多核苷酸和多肽及使用它们来表达感兴趣的表达产物的方法
EP3548015A1 (fr) 2016-11-30 2019-10-09 Yeda Research and Development Co. Ltd. Méthodes de traitement de maladies et de la toxicité hépathique
BR112019003912A2 (pt) 2016-12-01 2019-05-28 Univ Ramot composição, método para criação de um hidrogel, matriz, hidrogel, método para indução da formação ou regeneração de um tecido neuronal, método para tratamento de uma lesão do nervo e método para prevenção ou tratamento de choque neurogênico após lesão do nervo
IL308416A (en) 2016-12-02 2024-01-01 Bioverativ Therapeutics Inc Methods for the treatment of hemophilic arthritis with the help of chimeric blood coagulation factors
JP2019536794A (ja) 2016-12-02 2019-12-19 バイオベラティブ セラピューティクス インコーポレイテッド 凝固因子に対する免疫寛容を誘導する方法
US11268137B2 (en) 2016-12-09 2022-03-08 Boreal Genomics, Inc. Linked ligation
WO2018136163A2 (fr) 2016-12-09 2018-07-26 Theripion, Inc. Polypeptides de fusion apoa-1 en tandem
WO2018111835A1 (fr) 2016-12-12 2018-06-21 Dana-Farber Cancer Institute, Inc. Compositions et procédés pour le codage par code-barres moléculaire de molécules d'adn avant l'enrichissement des mutations et/ou la détection des mutations
EP4357455A2 (fr) 2016-12-12 2024-04-24 Grail, LLC Procédés de marquage et d'amplification de molécules de matrice d'arn pour préparer des bibliothèques de séquençage
AU2017375958A1 (en) 2016-12-12 2019-07-04 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
EP3555303B1 (fr) 2016-12-14 2022-12-21 Merck Sharp & Dohme Corp. Marqueurs génétiques humains associés à une réponse à des traitements ciblant la toxine b de clostridium difficile
IL267340B2 (en) 2016-12-15 2023-12-01 Nat Inst Biotechnology Negev Ltd Monoclonal antibodies against PCNA and their use
WO2018112320A1 (fr) 2016-12-16 2018-06-21 Alnylam Pharmaceuticals, Inc. Méthodes de traitement ou de prévention de maladies associées à ttr à l'aide de compositions d'arni de transthyrétine (ttr)
EP3555290B1 (fr) 2016-12-19 2022-11-02 Bio-Rad Laboratories, Inc. Adn marqué ayant une contiguïté préservée de marquage par gouttelettes
WO2018118978A1 (fr) 2016-12-20 2018-06-28 Bio-Rad Laboratories, Inc. Greffe faisant intervenir des uv sur des dispositifs microfluidiques
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
WO2018119399A1 (fr) 2016-12-23 2018-06-28 Grail, Inc. Procédés de préparation de banque à haute efficacité au moyen d'adaptateurs bicaténaire
EP3562893B1 (fr) 2016-12-28 2024-06-19 Bio-Rad Laboratories, Inc. Modification des propriétés de surface de dispositifs microfluidiques
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
WO2018124665A1 (fr) 2016-12-29 2018-07-05 Seegene, Inc. . Procédé pour réduire la formation de dimère d'amorce et augmenter l'efficacité d'amplification
WO2018129078A1 (fr) 2017-01-04 2018-07-12 Research Institute At Nationwide Children's Hospital Anticorps et vaccins dnabii présentant une activité améliorée
EP3565834A1 (fr) 2017-01-04 2019-11-13 The Research Institute at Nationwide Children's Hospital Fragments d'anticorps pour le traitement de troubles liés au biofilm
DK3565905T3 (da) 2017-01-04 2022-07-25 Mgi Tech Co Ltd Nukleinsyresekvensering ved hjælp af affinitetsreagenser
JP6754301B2 (ja) 2017-01-05 2020-09-09 株式会社日立製作所 ドロップレットデジタルpcrの測定方法および測定装置
US11718648B2 (en) 2017-01-05 2023-08-08 Evaxion Biotech A/S Vaccines targeting Pseudomonas aeruginosa
WO2018127786A1 (fr) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
US10100358B2 (en) 2017-01-10 2018-10-16 Paragon Genomics, Inc. Methods and compositions for reducing redundant molecular barcodes created in primer extension reactions
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
CN110249060A (zh) 2017-01-17 2019-09-17 生命技术公司 用于免疫组库测序的组合物和方法
WO2018134824A1 (fr) 2017-01-18 2018-07-26 Yeda Research And Development Co. Ltd. Cellules veto génétiquement modifiées et leur utilisation en immunothérapie
CA3050247A1 (fr) 2017-01-18 2018-07-26 Illumina, Inc. Procedes et systemes de generation et de correction d'erreur d'ensembles d'indices moleculaires uniques ayant des longueurs moleculaires heterogenes
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018136856A1 (fr) 2017-01-23 2018-07-26 Massachusetts Institute Of Technology Hybridation in situ en fluorescence par multiplexage à signal amplifié par l'intermédiaire d'une amplification et d'un séquençage de ligature par épissage
RU2021133626A (ru) * 2017-01-23 2022-01-31 Регенерон Фармасьютикалз, Инк. Варианты hsd17b13 и их применения
CA3050055C (fr) 2017-01-24 2023-09-19 Sequenom, Inc. Methodes et procedes d'evaluation de variations genetiques
WO2018140391A1 (fr) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions et procédés de détection d'un variant mutant d'un polynucléotide
CA3049778A1 (fr) 2017-01-26 2018-08-02 Oklahoma Medical Research Foundation Biomarqueurs de l'activite, de l'intensite et de l'eruption de la maladie du lupus erythemateux dissemine
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
KR20240038146A (ko) 2017-01-30 2024-03-22 얀센 바이오테크 인코포레이티드 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
MY196317A (en) 2017-01-30 2023-03-24 Astrazeneca Ab Estrogen Receptor Modulators
GB201701719D0 (en) 2017-02-02 2017-03-22 Neumann Diagnostics Ltd Method of assessing risk
IL250479A0 (en) 2017-02-06 2017-03-30 Sorek Rotem Genetically engineered cells expressing a disarm system that confers resistance to phages and methods for their production
KR20190115042A (ko) 2017-02-07 2019-10-10 얀센 바이오테크 인코포레이티드 활성 강직성 척추염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
US11920156B2 (en) 2017-02-09 2024-03-05 Indapta Therapeutics, Inc. Engineered natural killer (NK) cells and compositions and methods thereof
US20200063127A1 (en) 2017-02-15 2020-02-27 Massachusetts Institute Of Technology Dna writers, molecular recorders and uses thereof
GB201702500D0 (en) 2017-02-16 2017-04-05 Univ Sheffield Stable vamp reporter assay
US10988762B2 (en) 2017-02-16 2021-04-27 Bio-Rad Laboratories, Inc. Reverse transcriptases and uses thereof
WO2018156352A1 (fr) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Particules submicroniques enrobées d'acide nucléique pour une authentification
IL250799A0 (en) 2017-02-26 2017-04-30 The Nat Inst For Biotechnology In The Negev Ltd Soluble chimeras of dr3 and pro-pilot ether and their use
IL250916A0 (en) 2017-03-02 2017-06-29 Geiger Benjamin Methods for growing t cells in culture and their use
WO2018161031A1 (fr) 2017-03-02 2018-09-07 Youhealth Biotech, Limited Marqueurs de méthylation pour diagnostiquer un carcinome hépatocellulaire et un cancer du poumon
PE20191487A1 (es) 2017-03-03 2019-10-18 Rinat Neuroscience Corp Anticuerpos anti-gitr y metodos de uso de los mismos
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
EP3592377A4 (fr) 2017-03-09 2021-02-17 Diamedica Inc. Formes posologiques de kallicréine tissulaire 1
US11746381B2 (en) 2017-03-10 2023-09-05 Cancer Diagnostics Research Innvovations, LLC Methods for diagnosing and treating gastric cancer using miRNA expression
US20200150125A1 (en) 2017-03-12 2020-05-14 Yeda Research And Development Co., Ltd. Methods of diagnosing and prognosing cancer
WO2018167780A1 (fr) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Méthodes de diagnostic et de traitement du cancer
IL269203B1 (en) 2017-03-13 2024-05-01 Poseida Therapeutics Inc Preparations and methods for the selective elimination and replacement of hematopoietic stem cells
WO2018169901A1 (fr) 2017-03-13 2018-09-20 Massachusetts Institute Of Technology Promoteurs synthétiques
IL269363B2 (en) 2017-03-16 2024-02-01 Lineage Cell Therapeutics Inc Methods for measuring medical effects of treating retinal diseases
WO2018167621A1 (fr) 2017-03-16 2018-09-20 Pfizer Inc. Prototrophie à la tyrosine
WO2018167283A1 (fr) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés pour le diagnostic et le traitement d'un remodelage neuronal associé à un adénocarcinome canalaire pancréatique
CN110612110A (zh) 2017-03-17 2019-12-24 森迪生物科学公司 免疫调节细胞回路
US20200016207A1 (en) 2017-03-20 2020-01-16 Baylor College Of Medicine TRANSGENIC c-MPL PROVIDES LIGAND-DEPENDENT CO-STIMULATION AND CYTOKINE SIGNALS TO TCR-ENGINEERED T CELLS
EP3601611B1 (fr) 2017-03-24 2022-01-05 Life Technologies Corporation Adaptateurs polynucléotidiques et procédés d'utilisation de ces derniers
CA3176536C (fr) * 2017-03-24 2024-03-05 Gen-Probe Incorporated Compositions et procedes de detection d'agents pathogenes viraux dans des echantillons
WO2018175399A1 (fr) 2017-03-24 2018-09-27 Bio-Rad Laboratories, Inc. Amorces universelles en épingle à cheveux
WO2018175883A1 (fr) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions et procédés de détection ou quantification du virus parainfluenza
CA3225845A1 (fr) 2017-03-25 2018-10-04 Gen-Probe Incorporated Methodes et compositions pour detecter des combinaisons d'acides nucleiques viraux
EP3601602B1 (fr) 2017-03-29 2024-04-10 Crown Bioscience, Inc. (Taicang) Système et méthode de détermination de la sensibilité au cétuximab dans le cancer gastrique
WO2018183779A1 (fr) 2017-03-30 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University Détection multiple d'anticorps spécifiques à un isotype
WO2018183918A1 (fr) 2017-03-30 2018-10-04 Grail, Inc. Ligature améliorée dans la préparation d'une bibliothèque de séquençage
WO2018183897A1 (fr) 2017-03-31 2018-10-04 Grail, Inc. Efficacité plus élevée de capture de cibles à l'aide d'un déploiement de sondes
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
DK3607050T3 (da) 2017-04-05 2023-11-13 Yeda Res & Dev Ex vivo-dyrkningssystem og metoder til brugen af samme
WO2018191278A2 (fr) 2017-04-11 2018-10-18 Arbutus Biopharma Corporation Compositions ciblées
US20230192839A1 (en) 2017-04-12 2023-06-22 Pfizer Inc. Antibodies having conditional affinity and methods of use thereof
CN117838729A (zh) 2017-04-13 2024-04-09 森迪生物科学公司 组合癌症免疫疗法
EP3610264A1 (fr) 2017-04-13 2020-02-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic et de traitement d'un adénocarcinome canalaire pancréatique
CN110520735A (zh) 2017-04-14 2019-11-29 文塔纳医疗系统公司 解离固定组织的基于尺寸的分离
WO2018191548A2 (fr) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Anticorps antagonistes du facteur d du complément et leurs conjugués
SG11201909572QA (en) 2017-04-18 2019-11-28 Alnylam Pharmaceuticals Inc Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
EP3612557B1 (fr) 2017-04-18 2022-01-19 FUJIFILM Cellular Dynamics, Inc. Lymphocytes effecteurs immunitaires spécifiques de l'antigène
CN110520196A (zh) 2017-04-19 2019-11-29 艾洛基治疗公司 改进的t细胞组合物和方法
CN110785492B (zh) 2017-04-23 2024-04-30 伊鲁米纳剑桥有限公司 用于改进编索引的核酸文库中的样品鉴定的组合物和方法
ES2893528T3 (es) 2017-04-23 2022-02-09 Illumina Cambridge Ltd Composiciones y métodos para mejorar la identificación de muestras en colecciones de ácidos nucleicos indexadas
CN110770353A (zh) 2017-04-23 2020-02-07 伊鲁米那股份有限公司 用于改进编索引的核酸文库中的样品鉴定的组合物和方法
EP3615692A1 (fr) 2017-04-23 2020-03-04 Illumina Cambridge Limited Compositions et procédés pour améliorer l'identification d'échantillons dans des bibliothèques d'acides nucléiques indexées
US11572591B2 (en) 2017-04-26 2023-02-07 The Translational Genomics Research Institute Methods and assays for subtyping Staphylococcus aureus clonal complex 8 strains
CA3060369A1 (fr) 2017-05-01 2018-11-08 Illumina, Inc. Sequences index optimales pour sequencage multiplex massivement parallele
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
WO2018202792A1 (fr) 2017-05-04 2018-11-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction du syndrome de détresse respiratoire aiguë
EP3619533B1 (fr) 2017-05-05 2022-09-28 bioMérieux Procédé de détection d'une réponse cellulaire immune
IL252151A0 (en) 2017-05-07 2017-07-31 Fainzilber Michael Treatment of stress disorders
SG11201910070PA (en) 2017-05-08 2019-11-28 Illumina Inc Universal short adapters for indexing of polynucleotide samples
CN110831966A (zh) 2017-05-10 2020-02-21 阿里埃勒科学创新有限公司 纯化抗体的方法
CA3062075C (fr) 2017-05-11 2024-04-02 Gen-Probe Incorporated Compositions et procedes pour isoler des acides nucleiques cibles
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US11445692B2 (en) 2017-05-15 2022-09-20 Equi-Nom Ltd. Quantitative trait loci (QTL) associated with shatter resistant capsules in sesame and uses thereof
US11484543B2 (en) 2017-05-18 2022-11-01 The Rockefeller University Compositions and methods for diagnosing and treating diseases and disorders associated with mutant KCNJ5
WO2018213803A1 (fr) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Identification de néo-antigène immunogène
ES2939298T3 (es) 2017-05-21 2023-04-20 Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct Combinación de marcadores para el diagnóstico del cáncer
CA3064171A1 (fr) 2017-05-22 2018-11-29 4D Pharma Research Limited Compositions comprenant des souches bacteriennes
EP3635402B1 (fr) 2017-05-22 2024-01-24 Edith Cowan University Biomarqueur de maladie
US10752894B2 (en) 2017-05-23 2020-08-25 Bio-Rad Laboratories, Inc. Molecular barcoding
US20200172604A1 (en) 2017-05-23 2020-06-04 Technion Research & Development Foundation Limited Agents which inhibit gads dimerization and methods of use thereof
WO2018215590A1 (fr) 2017-05-24 2018-11-29 Gendiag.Exe, S.L. Événements thromboemboliques veineux associés au cancer
TW201907931A (zh) 2017-05-24 2019-03-01 英商4D製藥研究有限公司 包含細菌菌株之組合物
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
MA49352A (fr) 2017-05-26 2020-04-08 Abvitro Llc Séquençage de bibliothèque de polynucléotides à haut rendement et analyse de transcriptome
EP3630973A1 (fr) 2017-05-31 2020-04-08 Tropic Biosciences UK Limited Méthodes de sélection de cellules comprenant des événements d'édition de génome
GB201708665D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing extractability of solids from coffee beans
GB201708662D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing shelf-life of banana
WO2018223055A1 (fr) 2017-06-02 2018-12-06 Affymetrix, Inc. Procédés basés sur un réseau pour analyser des échantillons mixtes à l'aide de sondes spécifiques d'allèles marquées différemment
KR20200016292A (ko) 2017-06-02 2020-02-14 화이자 인코포레이티드 재조합 robo2 단백질, 조성물, 방법 및 그의 용도
JOP20190280A1 (ar) 2017-06-02 2019-12-02 Janssen Pharmaceutica Nv مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية
KR102505349B1 (ko) 2017-06-02 2023-03-02 화이자 인코포레이티드 Flt3에 특이적인 항체 및 이의 용도
SG10202108528QA (en) 2017-06-02 2021-09-29 Pfizer Chimeric antigen receptors targeting flt3
WO2018223053A1 (fr) 2017-06-02 2018-12-06 Affymetrix, Inc. Procédés basés sur un réseau pour analyser des échantillons mixtes à l'aide de sondes spécifiques d'allèles marquées différemment
CA3064603A1 (fr) 2017-06-07 2018-12-13 Gen-Probe Incorporated Detection d'acide nucleique d'espece babesia dans un echantillon
WO2018224861A1 (fr) 2017-06-07 2018-12-13 International Rice Research Institute Augmentation de la production de semences hybrides par un taux de croisement plus élevé chez des plantes graminacées stériles cytoplasmiques et matériaux et procédés associés
CN110997932B (zh) 2017-06-07 2024-06-04 俄勒冈健康科学大学 用于甲基化测序的单细胞全基因组文库
JP7270557B2 (ja) 2017-06-09 2023-05-10 ファイザー・インク 抗robo2抗体、組成物、方法、およびその使用
WO2018229764A1 (fr) 2017-06-13 2018-12-20 Yeda Research And Development Co. Ltd. Traitement de la sclérose en plaques avancée ou progressive
WO2018229767A1 (fr) 2017-06-13 2018-12-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés pour améliorer les rendements de production de protéines cellulaires
DK3600364T3 (da) 2017-06-14 2020-08-31 4D Pharma Res Ltd Sammensætninger omfattende en bakteriestamme af slægten megasphaera og anvendelser deraf
HUE052319T2 (hu) 2017-06-14 2021-04-28 4D Pharma Res Ltd Baktériumtörzseket tartalmazó készítmények
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
EP3642362A1 (fr) 2017-06-20 2020-04-29 Illumina, Inc. Procédés et compositions pour résoudre les inefficacités dans des réactions d'amplification
WO2018237327A1 (fr) 2017-06-22 2018-12-27 Triact Therapeutics, Inc. Procédés de traitement d'un glioblastome
US10323289B2 (en) 2017-06-26 2019-06-18 Institut Pasteur Treatments to eliminate HIV reservoirs and reduce viral load
WO2019002178A1 (fr) 2017-06-26 2019-01-03 Thermo Fisher Scientific Baltics Uab Mutants d'adn polymérases thermophiles
CN111032643B (zh) 2017-06-27 2023-05-30 詹森药业有限公司 新的喹啉酮化合物
EP4282982A3 (fr) 2017-06-30 2024-01-10 Life Technologies Corporation Procédés de préparation de bibliothèque ainsi que compositions et utilisations correspondantes
EP4286055A3 (fr) 2017-07-10 2024-02-28 Gen-Probe Incorporated Système analytique et méthodes pour l'amplification d'acides nucléics utilisant l'attribution de paramètres à l'échantillon
US20200131555A1 (en) 2017-07-11 2020-04-30 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
US11466323B2 (en) 2017-07-13 2022-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dual-probe digital droplet PCR strategy for specific detection of tissue-specific circulating DNA molecules
WO2019012542A1 (fr) 2017-07-13 2019-01-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Détection d'adn spécifique d'un tissu
US20200340057A1 (en) 2017-07-13 2020-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dna targets as tissue-specific methylation markers
WO2019014309A1 (fr) 2017-07-13 2019-01-17 Verdezyne (Abc), Llc Procédés biologiques pour modifier un flux de carbone cellulaire
AU2018304618A1 (en) 2017-07-15 2020-03-05 Aleph Farms Ltd Cultured meat compositions
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
US20190316101A1 (en) 2017-07-18 2019-10-17 Howard Hughes Medical Institute Methods and compositions for genetically manipulating genes and cells
WO2019017680A2 (fr) 2017-07-19 2019-01-24 국민대학교 산학협력단 Micro-arn utilisé en tant que biomarqueur de la maladie de parkinson et kit diagnostique le mettant en oeuvre
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
WO2019018647A1 (fr) 2017-07-20 2019-01-24 Pfizer Inc. Anticorps anti-gd3 et conjugués anticorps-médicament
WO2019018764A1 (fr) 2017-07-21 2019-01-24 Genecentric Therapeutics, Inc. Méthodes de détermination de réponse à des inhibiteurs de parp
WO2019023243A1 (fr) 2017-07-24 2019-01-31 Dana-Farber Cancer Institute, Inc. Procédés et compositions pour sélectionner et amplifier des cibles d'adn dans un mélange de réaction unique
IL253642A0 (en) 2017-07-24 2017-09-28 Seger Rony Combined treatment for cancer
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
WO2019023291A2 (fr) 2017-07-25 2019-01-31 Dana-Farber Cancer Institute, Inc. Compositions et procédés de production et de décodage de bibliothèques d'arn guide et utilisations associées
CN110945018A (zh) 2017-07-27 2020-03-31 诺华股份有限公司 抗脱落酶的trem2变体
WO2019027869A1 (fr) 2017-07-31 2019-02-07 Massachusetts Institute Of Technology Stabilisant de transcript induite par clivage de l'arn et ses utilisations
CA3071769A1 (fr) 2017-07-31 2019-02-07 Reflection Biotechnologies Limited Modeles cellulaires et therapies pour des maladies oculaires
WO2019027414A1 (fr) 2017-07-31 2019-02-07 Massachusetts Institute Of Technology Détecteurs de micro-arn à entrées multiples haute performance et leurs utilisations
JP6998404B2 (ja) 2017-08-01 2022-02-04 深▲セン▼恒特基因有限公司 標的ヌクレオチド配列の富化及び決定方法
MX2020001336A (es) 2017-08-03 2020-08-20 Synthorx Inc Conjugados de citoquina para el tratamiento de enfermedades autoinmunes.
WO2019032525A1 (fr) 2017-08-07 2019-02-14 Genecentric Therapeutics, Inc. Procédé de sous-typage d'un carcinome épidermoïde de la tête et du cou
EP3664811A2 (fr) 2017-08-08 2020-06-17 The U.S.A. as represented by the Secretary, Department of Health and Human Services Compositions et procédés pour inhiber la transcriptase inverse du vih-1
CN111247251A (zh) 2017-08-09 2020-06-05 比奥维拉迪维治疗股份有限公司 核酸分子及其用途
WO2019032809A1 (fr) 2017-08-11 2019-02-14 Gen-Probe Incorporated Compositions et méthodes de détection de staphylococcus aureus
MX2020001759A (es) 2017-08-14 2020-12-10 Epizyme Inc Inhibidores de histona acetiltransferasa de la familia myst.
IL253984A0 (en) 2017-08-14 2017-09-28 Yeda Res & Dev Immunotherapy against aranviruses that bind through transferrin receptor 1 (tfr1
US11898187B2 (en) 2017-08-15 2024-02-13 Northwestern University Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases
WO2019036605A2 (fr) 2017-08-17 2019-02-21 Massachusetts Institute Of Technology Agents de liaison à spécificité multiple de chimiokines cxc et leurs utilisations
AU2018317902A1 (en) 2017-08-18 2020-03-05 Sera Prognostics, Inc. Pregnancy clock proteins for predicting due date and time to birth
EP3668876B1 (fr) 2017-08-18 2024-01-24 Cothera Bioscience, Inc. Forme polymorphe de tg02
US11692166B2 (en) 2017-08-23 2023-07-04 Technion Research & Development Foundation Limited Compositions and methods for improving alcohol tolerance in yeast
EP4212631A1 (fr) 2017-09-01 2023-07-19 Life Technologies Corporation Compositions et méthodes pour séquençage de répertoire immunologique
WO2019043656A1 (fr) 2017-09-01 2019-03-07 Genus Plc Procédés et systèmes d'évaluation et/ou de quantification de populations de spermatozoïdes à asymétrie sexuelle
CN116849114A (zh) 2017-09-01 2023-10-10 奥驰亚客户服务有限公司 与烟草中提高的氮利用效率有关的方法和组合物
EP3679370A1 (fr) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire
JP2020532987A (ja) 2017-09-08 2020-11-19 ポセイダ セラピューティクス,インコーポレイティド キメラリガンド受容体(clr)介在性の条件遺伝子発現のための組成物および方法
WO2019051443A1 (fr) 2017-09-11 2019-03-14 Insideoutbio, Inc. Procédés et compositions pour améliorer l'immunogénicité de tumeurs
US11267822B2 (en) 2017-09-13 2022-03-08 The Regents Of The University Of Michigan BET bromodomain protein degraders with cleavable linkers
WO2019055819A1 (fr) 2017-09-14 2019-03-21 Grail, Inc. Procédés de préparation d'une bibliothèque de séquençage à partir d'adn simple brin
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
WO2019055829A1 (fr) 2017-09-15 2019-03-21 Nazarian Javad Procédés de détection de biomarqueurs du cancer
EP3684796A4 (fr) 2017-09-18 2021-06-16 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University Polypeptides régulateurs de succinate et utilisation associée
CN111373044A (zh) 2017-09-19 2020-07-03 热带生物科学英国有限公司 修饰用于沉默基因表达的植物非编码rna分子的特异性的方法
CA3076321A1 (fr) 2017-09-20 2019-03-28 Novogy, Inc. Production heterologue d'acide 10-methylstearique par des cellules exprimant une methyltransferase recombinee
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗il12/il23抗體治療狼瘡之安全且有效之方法
US11624095B2 (en) 2017-09-27 2023-04-11 Case Western Reserve University Method of quantifying HIV reservoirs by induced transcription based sequencing
WO2019066238A2 (fr) 2017-09-28 2019-04-04 주식회사 씨젠 Procédé et dispositif d'affichage de données d'amplification
EP3688191B1 (fr) 2017-09-28 2022-03-02 Grail, LLC Enrichissement de fragments d'acides nucléiques courts dans la préparation de bibliothèques de séquençage
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
EP3688184A1 (fr) 2017-09-29 2020-08-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés pour prédire le risque de développer une colonisation/infection pulmonaire parpseudomonas aeruginosa
WO2019063661A1 (fr) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh Compositions et méthodes pour la détection de trichomonas vaginalis
CA3074510A1 (fr) 2017-10-03 2019-04-11 The Regents Of The University Of Colorado Procede de differenciation de cultivars de plante de cannabis sur la base de paralogues de synthase de cannabinoides
WO2019072888A1 (fr) 2017-10-11 2019-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la réponse thérapeutique dans le cancer hépatocellulaire
EP3697531B1 (fr) 2017-10-20 2022-07-27 Stilla Technologies Émulsions à stabilité améliorée
US20200256879A1 (en) 2017-10-24 2020-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for predicting and treating intracranial aneurysm
SG11202002753QA (en) 2017-10-26 2020-05-28 Nat Univ Singapore A new approach for universal monitoring of minimal residual disease in acute myeloid leukemia
CN111556876A (zh) 2017-10-27 2020-08-18 辉瑞公司 对cd123具有特异性的抗体和抗体-药物缀合物及其用途
WO2019086517A1 (fr) 2017-10-31 2019-05-09 Roche Diagnostics Gmbh Particules magnétiques améliorées et leur utilisation
AU2018360697A1 (en) 2017-11-01 2020-05-14 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
AU2018359532B2 (en) 2017-11-01 2024-03-28 Allogene Therapeutics, Inc. Modified caspase-9 polypeptides and methods of use thereof
WO2019089982A1 (fr) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Procédé d'évaluation de l'activité de récepteurs antigéniques de recombinaison
WO2019089959A1 (fr) 2017-11-02 2019-05-09 Bio-Rad Laboratories, Inc. Analyse génomique basée sur la transposase
EP3703683A1 (fr) 2017-11-03 2020-09-09 Aurigene Discovery Technologies Limited Double inhibiteurs de voies tim-3 et pd-1
AU2018358016A1 (en) 2017-11-03 2020-05-07 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
CN111386128A (zh) 2017-11-06 2020-07-07 奥瑞基尼探索技术有限公司 用于免疫调节的联合疗法
MX2020004507A (es) 2017-11-09 2020-08-13 Alnylam Pharmaceuticals Inc Ensayos y métodos para determinar la expresión del gen de quimiotaxina 2 derivada de leucocitos (lect2).
US11673921B2 (en) 2017-11-10 2023-06-13 Northwestern University Cell-free protein synthesis platform derived from cellular extracts of Vibrio natriegens
KR20200081476A (ko) 2017-11-13 2020-07-07 라이프 테크놀로지스 코포레이션 요로 미생물 검출을 위한 조성물, 방법 및 키트
IL255664A0 (en) 2017-11-14 2017-12-31 Shachar Idit Hematopoietic stem cells with enhanced properties
US20200385719A1 (en) 2017-11-16 2020-12-10 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
MX2020005093A (es) 2017-11-17 2020-08-13 Oms Invest Inc Plantas que comprenden secuencias de eventos resistentes a herbicidas, materiales vegetales y metodos para la deteccion de los mismos.
EP3710595A1 (fr) 2017-11-17 2020-09-23 Gen-Probe Incorporated Compositions et procédés pour détecter l'acide nucléique de c1orf43
EP3714054A1 (fr) 2017-11-20 2020-09-30 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant p amyloïde serique et leurs procédés d'utilisation
US11214536B2 (en) 2017-11-21 2022-01-04 Inspirna, Inc. Polymorphs and uses thereof
MX2020005342A (es) 2017-11-24 2020-10-14 Janssen Pharmaceutica Nv Compuestos de pirazolopiridinona.
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
WO2019106667A1 (fr) 2017-11-29 2019-06-06 Weedout Ltd. Compositions, kits et procédés de lutte contre les mauvaises herbes du genre amaranthus
EP3717032B1 (fr) 2017-11-29 2023-02-15 Ramot at Tel-Aviv University Ltd. Procédés de traitement prophylactique ou thérapeutique de choc neurogénique
WO2019106126A1 (fr) 2017-12-01 2019-06-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Modulateurs mdm2 pour le diagnostic et le traitement du liposarcome
PE20210554A1 (es) 2017-12-01 2021-03-17 Pfizer Anticuerpos anti-cxcr5 y composiciones y usos de los mismos
EP3716993A1 (fr) 2017-12-03 2020-10-07 Yeda Research and Development Co. Ltd Traitement d'une maladie cardiaque ischémique
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
EP3720974A1 (fr) 2017-12-07 2020-10-14 Institut National de la Sante et de la Recherche Medicale (INSERM) Procédés de dépistage d'un cancer chez un sujet
WO2019118652A1 (fr) 2017-12-12 2019-06-20 Essenlix Corporation Manipulation d'échantillon et dosage avec changement de température rapide
UY38003A (es) 2017-12-12 2019-06-28 Amgen Inc Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
WO2019118550A1 (fr) 2017-12-13 2019-06-20 Gen-Probe Incorporated Procédés de traitement d'un échantillon biologique
JP2021506274A (ja) 2017-12-15 2021-02-22 ジェン−プローブ・インコーポレーテッド 毒素産生Clostridium difficileを検出するための組成物および方法
WO2019118925A1 (fr) 2017-12-15 2019-06-20 Grail, Inc. Procédés d'enrichissement de lectures de duplex pour le séquençage et la correction d'erreurs
WO2019116376A1 (fr) 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Modulateurs du complexe signalosome cop9 (csn) et leurs utilisations
AU2018388484A1 (en) 2017-12-18 2020-07-30 Alnylam Pharmaceuticals, Inc. High mobility group box-1 (HMGB1) iRNA compositions and methods of use thereof
CN112218885B (zh) 2017-12-20 2024-06-18 波赛达治疗公司 Vcar组合物和使用方法
WO2019121872A1 (fr) 2017-12-20 2019-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de diagnostic et de traitement du cancer du foie
WO2019126803A1 (fr) 2017-12-22 2019-06-27 Grail, Inc. Suppression des erreurs par des méthodes améliorées de préparation de bibliothèques
EP3505181B1 (fr) 2017-12-28 2021-07-07 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Préparation de thérapie de remplacement d'enzymes pour mucopolysaccharidose iiid
EP3731965A1 (fr) 2017-12-28 2020-11-04 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Procédé pour reproduire des rythmes circadiens sur une puce microfluidique
WO2019135567A1 (fr) 2018-01-05 2019-07-11 Seegene, Inc. . Procédé de détermination de la présence ou de l'absence de m. tuberculosis, m. bovis et m. bovis bcg dans un échantillon
WO2019140009A1 (fr) 2018-01-09 2019-07-18 Cibus Us Llc Gènes de résistance à l'égrenage et mutations
CA3127176A1 (fr) 2018-01-25 2019-08-01 Mia Levite Procedes d'immunotherapie amelioree
IL257225A (en) 2018-01-29 2018-04-09 Yeda Res & Dev Treatment of sarcoma
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
JP2021517825A (ja) 2018-01-30 2021-07-29 チルドレンズ メディカル センター コーポレーションChildren’S Medical Center Corporation Bacillus系を用いたボツリヌスニューロトキシンの生産
EP4324962A3 (fr) 2018-01-31 2024-05-08 Bio-Rad Laboratories, Inc. Procédés et compositions pour déconvolutionner des codes à barres de partition
WO2019152747A1 (fr) 2018-01-31 2019-08-08 Juno Therapeutics, Inc. Méthodes et réactifs d'évaluation de la présence ou de l'absence d'un virus compétent pour la réplication
IL257269A (en) 2018-01-31 2018-04-09 Olender Tsviya Signaling is directed to the endoplasmic reticulum
PE20210708A1 (es) 2018-02-01 2021-04-16 Pfizer Anticuerpos especificos para cd70 y sus usos
AU2019215063A1 (en) 2018-02-01 2020-09-03 Bioverativ Therapeutics, Inc. Use of lentiviral vectors expressing Factor VIII
CN112020518A (zh) 2018-02-01 2020-12-01 辉瑞公司 靶向cd70的嵌合抗原受体
US20220128557A1 (en) 2018-02-08 2022-04-28 Phenofast Ltd. Appartatus and methods for real-time cell monitoring
WO2019155465A1 (fr) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Procédés d'identification et d'utilisation d'agents pour traiter des maladies associées à un dysfonctionnement de la barrière intestinale
WO2019155459A1 (fr) 2018-02-08 2019-08-15 Yeda Research And Development Co. Ltd. Inhibiteurs du protéasome 20s
US20220372572A1 (en) 2018-02-09 2022-11-24 Genincode Uk, Ltd. Prediction of pregnancy loss
CA3090785A1 (fr) 2018-02-14 2019-08-22 John Daniel Dobak Iii Nouveaux classificateurs de genes et leurs utilisations dans des cancers de la peau sans melanome
US11970786B2 (en) 2018-02-15 2024-04-30 Bioo Scientific Corporation Methods and kits for detecting contamination and sample misidentification
US20210087630A1 (en) 2018-02-18 2021-03-25 Yissum Research Development Company Of The Hebrew University Of Jerusalmem Ltd. Cell free dna deconvolusion and use thereof
WO2019162945A1 (fr) 2018-02-23 2019-08-29 Carmel Haifa University Economic Corporation Ltd. Méthodes de traitement d'un trouble de la mémoire et d'un dysfonctionnement cognitif
WO2019166946A1 (fr) 2018-02-28 2019-09-06 Pfizer Inc. Variants d'il-15 et leurs utilisations
EP3759493A1 (fr) 2018-02-28 2021-01-06 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Méthodes de diagnostic et de traitement du cancer de la vessie
CN111819192A (zh) 2018-03-02 2020-10-23 艾洛基治疗公司 可诱导的嵌合细胞激素受体
WO2019168697A1 (fr) 2018-03-02 2019-09-06 Northwestern University Surexpression de foxc1 pour traiter la vascularisation cornéenne
WO2019171252A1 (fr) 2018-03-05 2019-09-12 Janssen Biotech, Inc. Méthodes de traitement de la maladie de crohn avec un anticorps spécifique anti-il23
IT201800003299A1 (it) 2018-03-06 2019-09-06 Centro Di Sperimentazione Laimburg Oligonucleotidi e metodi per il controllo interno di reazioni di amplificazione degli acidi nucleici.
SG11202008659TA (en) 2018-03-07 2020-10-29 Poseida Therapeutics Inc Cartyrin compositions and methods for use
EP3765034A1 (fr) 2018-03-12 2021-01-20 Yeda Research and Development Co. Ltd Traitement d'une maladie cardiaque
CN112119166A (zh) 2018-03-13 2020-12-22 耶路撒冷希伯来大学伊萨姆研发有限公司 无细胞dna染色质免疫沉淀的诊断应用
JP2021517152A (ja) 2018-03-15 2021-07-15 ビオンド バイオロジクス リミテッド 可溶性免疫受容体cd28を減少させるための方法および組成物
ES2960914T3 (es) 2018-03-16 2024-03-07 Gopath Laboratories Llc Métodos para la detección personalizada de la reaparición del cáncer o de la metástasis y/o evaluación de la respuesta al tratamiento
KR20200135986A (ko) 2018-03-19 2020-12-04 멀티비르 인코포레이티드 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물
US11530432B2 (en) 2018-03-19 2022-12-20 Northwestern University Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
US20190292596A1 (en) 2018-03-21 2019-09-26 Roche Molecular Systems, Inc. Modified nucleoside phosphates with high thermal stability
WO2019180137A1 (fr) 2018-03-21 2019-09-26 F. Hoffmann-La Roche Ag Adn polymérases pour incorporation efficiente et efficace de dntp méthylés
WO2019183582A1 (fr) 2018-03-23 2019-09-26 Life Technologies Corporation Surveillance du répertoire immun
WO2019191122A1 (fr) 2018-03-26 2019-10-03 Qiagen Sciences, Llc Préparations de bibliothèques intégrées d'adn et d'arn et leurs utilisations
TW202003551A (zh) 2018-03-28 2020-01-16 美商必治妥美雅史谷比公司 介白素-2/介白素-2受體阿法融合蛋白及其使用方法
CN112236446A (zh) 2018-03-29 2021-01-15 弗埃塞股份有限公司 Lfa3变体及其组合物与用途
KR20210005031A (ko) 2018-03-29 2021-01-13 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. Pten 억제제를 포함하는 소포 및 이의 용도
EP3774047A1 (fr) 2018-03-29 2021-02-17 Yeda Research and Development Co. Ltd Utilisation de gradients de champ électrique pour commander l'expression génique
IL258467A (en) 2018-03-29 2018-07-04 Ilana Kolodkin Gal Methods of disrupting a biofilm and/or preventing formation of same
WO2019185778A1 (fr) 2018-03-29 2019-10-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction du risque de développer une colonisation/infection pulmonaire par pseudomonas aeruginosa
CN111936520A (zh) 2018-04-02 2020-11-13 百时美施贵宝公司 抗trem-1抗体及其用途
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
WO2019198084A1 (fr) 2018-04-12 2019-10-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions anti-âge et procédés d'utilisation
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
US11725224B2 (en) 2018-04-16 2023-08-15 Northwestern University Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates
WO2019202536A1 (fr) 2018-04-18 2019-10-24 St. Jude Children's Research Hospital Essais de génotypage pour identifier des mutations dans xaf1
CN112004941B (zh) 2018-04-20 2023-10-27 Seegene株式会社 用于检测样品中的多个靶核酸序列的方法及装置
EP3784787A1 (fr) 2018-04-27 2021-03-03 Pioneer Hi-Bred International, Inc. Événement de maïs dp-032218-9 et procédés de détection de celui-ci
EP3788626A1 (fr) 2018-04-29 2021-03-10 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Procédé de sélection d'une thérapie spécifique à un patient
EP3787748A1 (fr) 2018-05-01 2021-03-10 OrfoNeuro ApS Traitement de la céroïde-lipofuscinose neuronale
GB201807192D0 (en) 2018-05-01 2018-06-13 Tropic Biosciences Uk Ltd Compositions and methods for reducing caffeine content in coffee beans
TW202016304A (zh) 2018-05-14 2020-05-01 美商阿尼拉製藥公司 血管收縮素原(AGT)iRNA組成物及其使用方法
WO2019220441A1 (fr) 2018-05-15 2019-11-21 Hadasit Medical Research Services And Development Ltd. Compositions et méthodes de traitement du cancer résistant à un agent anticancéreux
IL259392A (en) 2018-05-15 2018-08-01 Yeda Res & Dev Vaccination with cancer neo-antigens
MX2020012297A (es) 2018-05-16 2021-03-25 Centre Hospitalier Regional Et Univ De Brest Biomarcadores sanguíneos de accidente cerebrovascular.
KR102447811B1 (ko) 2018-05-17 2022-09-27 일루미나, 인코포레이티드 감소된 증폭 편향을 갖는 고속대량 단일 세포 서열분석
WO2019222682A1 (fr) 2018-05-18 2019-11-21 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a
WO2019222036A1 (fr) 2018-05-18 2019-11-21 Insideoutbio, Inc. Protéines argonautes génétiquement modifiées présentant une activité d'extinction génique améliorée et leurs méthodes d'utilisation
US11434292B2 (en) 2018-05-23 2022-09-06 Pfizer Inc. Antibodies specific for CD3 and uses thereof
AU2019274655B2 (en) 2018-05-23 2023-03-09 Pfizer Inc. Antibodies specific for GUCY2c and uses thereof
EP3802880A1 (fr) 2018-05-25 2021-04-14 Illumina, Inc. Signatures d'arn circulants spécifiques de la prééclampsie
EP3691635B1 (fr) 2018-05-25 2023-07-05 Arca Biopharma, Inc. Procédés et compositions impliquant du bucindolol pour le traitement de la fibrillation auriculaire
EP3801614A1 (fr) 2018-05-27 2021-04-14 BioLineRx Ltd. Agi-134 combinée à un inhibiteur de point de contrôle pour le traitement de tumeurs solides
TW202015726A (zh) 2018-05-30 2020-05-01 瑞士商諾華公司 Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814621B2 (en) 2018-06-01 2023-11-14 Northwestern University Expanding the chemical substrates for genetic code reprogramming
BR112019027750A2 (pt) 2018-06-04 2022-06-14 Illumina Inc Bibliotecas transcriptônicas de célula única altorendimento, e métodos de fabricação e de usos
US20210238289A1 (en) 2018-06-04 2021-08-05 Biogen Ma Inc. Anti-vla-4 antibodies having reduced effector function
CA3102975A1 (fr) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Procedes de regeneration et de transformation de cannabis
CA3102978A1 (fr) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Constructions d'acide nucleique et procedes d'utilisation de celles-ci
GB201809449D0 (en) * 2018-06-08 2018-07-25 Imperial Innovations Ltd Method for detecting a single nucleotide polymorphism(SNP)
WO2019234221A1 (fr) 2018-06-08 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de stratification et de traitement d'un patient souffrant de leucémie lymphoïde chronique
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
US11873322B2 (en) 2018-06-25 2024-01-16 Yeda Research And Development Co. Ltd. Systems and methods for increasing efficiency of genome editing
WO2020002621A2 (fr) 2018-06-29 2020-01-02 F. Hoffmann-La Roche Ag Détection améliorée d'instabilité microsatellitaire
EP3817720A2 (fr) 2018-07-03 2021-05-12 Bristol-Myers Squibb Company Formulations de fgf21
AU2019297677A1 (en) 2018-07-04 2021-02-25 Ukko Inc. Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease
US20210269860A1 (en) 2018-07-08 2021-09-02 Yeda Research And Development Co. Ltd. Person-specific assessment of probiotics responsiveness
WO2020014400A1 (fr) 2018-07-10 2020-01-16 Gen-Probe Incorporated Procédés et systèmes de détection et de quantification d'acides nucléiques
EA202190249A1 (ru) 2018-07-11 2021-05-21 Иммунити Фарма Лтд. Пептидные соединения и их терапевтическое применение
KR20210044220A (ko) 2018-07-11 2021-04-22 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
US20210278406A1 (en) 2018-07-13 2021-09-09 Varct Diagnostic Aps Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
MX2018008742A (es) 2018-07-16 2020-01-17 Sigma Alimentos Sa De Cv Metodo y kit de diagnostico para detectar multiple y simultaneamente una combinacion de bacterias gram positivas y/o bacterias gram negativas.
WO2020018715A1 (fr) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Protéines de fusion à base d'échafaudage d'immunoglobuline multimère soluble et leurs utilisations
EP3824295A4 (fr) 2018-07-18 2022-04-27 Janssen Biotech, Inc. Prédicteurs de réponse prolongée après le traitement avec un anticorps spécifique anti-il23
WO2020018837A1 (fr) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions et méthodes pour le séquençage du répertoire immunitaire
US20220073983A1 (en) 2018-07-18 2022-03-10 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
WO2020016377A1 (fr) 2018-07-19 2020-01-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinaison pour le traitement du cancer
WO2020028194A1 (fr) 2018-07-30 2020-02-06 Readcoor, Inc. Procédés et systèmes de traitement ou d'analyse d'échantillons
JP7479343B2 (ja) 2018-07-31 2024-05-08 コルプラント リミテッド タバコのトランスジェニックイベント、並びにその検出方法およびその使用
US11339395B2 (en) 2018-08-01 2022-05-24 Massachusetts Institute Of Technology RNA-based regulatory technologies for miRNA sensors
CA3106975A1 (fr) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions et procedes de detection d'acides nucleiques du virus d'epstein-barr
WO2020028609A1 (fr) 2018-08-01 2020-02-06 Massachusetts Institute Of Technology Capteur de micro-arn utilisant la phosphorylation
CA3108105A1 (fr) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, procedes et kits pour la detection de mycoplasma genitalium
SG11202101157VA (en) 2018-08-09 2021-03-30 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof for non-viral gene therapy
CN113166736A (zh) 2018-08-13 2021-07-23 奥尔胡斯大学 具有改变的激动剂特异性和亲和性的基因改变的LysM受体
US20210163976A1 (en) 2018-08-13 2021-06-03 Aarhus Universitet Genetically altered plants expressing heterologous receptors that recognize lipo-chitooligosaccharides
AU2019321375A1 (en) 2018-08-13 2021-03-11 Alnylam Pharmaceuticals, Inc. Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof
IL261156A (en) 2018-08-14 2020-02-27 Fass Deborah Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same
MX2021001709A (es) 2018-08-15 2021-05-27 Illumina Inc Composiciones y metodos para mejorar el enriquecimiento de genotecas.
US20210169908A1 (en) 2018-08-16 2021-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment for gene reactivation
US11566066B2 (en) 2018-08-20 2023-01-31 Pfizer Inc. Anti-GDF15 antibodies, compositions and methods of use
EP3841202B1 (fr) 2018-08-20 2023-10-04 Bio-Rad Laboratories, Inc. Génération de séquences nucléotidiques par co-localisation de billes à code-barres dans des partitions
WO2020041360A1 (fr) 2018-08-21 2020-02-27 Quidel Corporation Anticorps dbpa et leurs utilisations
EP3841224A1 (fr) 2018-08-21 2021-06-30 Gen-Probe Incorporated Compositions et procédés d'amplification, de détection ou de quantification de cytomégalovirus humain
EP3613855A1 (fr) 2018-08-23 2020-02-26 Clariant Produkte (Deutschland) GmbH Procédé de production d'une bibliothèque d'acide nucléique
KR20210063347A (ko) 2018-08-24 2021-06-01 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
EP3841201A1 (fr) 2018-08-24 2021-06-30 Yeda Research and Development Co. Ltd Procédés de modulation de la polarisation de macrophages m2 et leur utilisation en thérapie
EP3844306A2 (fr) 2018-08-28 2021-07-07 10X Genomics, Inc. Augmentation de la résolution d'un réseau spatial
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
EP3844308A1 (fr) 2018-08-28 2021-07-07 10X Genomics, Inc. Résolution de réseaux spatiaux
CA3111076A1 (fr) 2018-08-30 2020-03-05 Tenaya Therapeutics, Inc. Reprogrammation de cellules cardiaques avec la myocardine et ascl1
JP2021534807A (ja) 2018-09-05 2021-12-16 マックス−デルブリュック−ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ−ゲマインシャフト 合成シス調節dnaを操作する方法
US20220389077A1 (en) 2018-09-05 2022-12-08 Poseida Therapeutics, Inc. Allogeneic cell compositions and methods of use
WO2020051301A1 (fr) 2018-09-06 2020-03-12 Hygiena, Llc Séquences et leur utilisation pour la détection et la caractérisation de e. coli o157:h7
CA3107467A1 (fr) 2018-09-07 2020-03-12 Sequenom, Inc. Procedes et systemes pour detecter un rejet de greffe
BR112021004287A2 (pt) 2018-09-07 2021-08-03 Pfizer Inc. anticorpos anti-avss8 e composições e usos dos mesmos
US11408030B2 (en) 2018-09-10 2022-08-09 Andy Madrid Test for detecting Alzheimer's disease
JP7320601B2 (ja) 2018-09-11 2023-08-03 上▲海▼市公共▲衛▼生▲臨▼床中心 広域スペクトルな抗インフルエンザワクチン免疫原及びその使用
EP3850086A1 (fr) 2018-09-13 2021-07-21 F. Hoffmann-La Roche AG Adn polymérase mutant(s) à capacité de déplacement de brin améliorée
CA3112792A1 (fr) 2018-09-14 2020-03-19 Prelude Corporation Methode de selection pour le traitement d'individus presentant un risque de cancer du sein invasif
WO2020060948A1 (fr) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production de cannabinoïdes dans une levure à l'aide d'une charge d'alimentation d'acides gras
CA3105385A1 (fr) 2018-09-18 2020-03-26 Alnylam Pharmaceuticals, Inc. Compositions d'arni de cetohexokinase (khk) et leurs procedes d'utilisation
JP2022501381A (ja) 2018-09-20 2022-01-06 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドYeda Research And Development Co.Ltd. 筋萎縮性側索硬化症の治療方法
SG11202102546XA (en) 2018-09-21 2021-04-29 Janssen Pharmaceutica Nv Treatment of cholangiocarcinoma
EP3856225A1 (fr) 2018-09-25 2021-08-04 BioLineRx Ltd. Procédés de sélection d'un traitement contre un cancer associé aux récepteurs cxcr4
WO2020069029A1 (fr) 2018-09-26 2020-04-02 Emendobio Inc. Nouvelles nucléases crispr
AU2019350777A1 (en) 2018-09-27 2021-05-20 Gen-Probe Incorporated Compositions and methods for detecting Bordetella pertussis and Bordetellaparapertussis nucleic acid
SG11202100935TA (en) 2018-09-28 2021-02-25 Massachusetts Inst Technology Collagen-localized immunomodulatory molecules and methods thereof
TW202028465A (zh) 2018-09-28 2020-08-01 美商阿尼拉製藥公司 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關眼部疾病之使用方法
US20220017980A1 (en) 2018-10-01 2022-01-20 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
AU2019355194A1 (en) 2018-10-05 2021-04-22 Research Institute At Nationwide Children's Hospital Compositions and methods for enzymatic disruption of bacterial biofilms
MX2021003999A (es) 2018-10-08 2021-06-23 Univ Michigan Regents Moleculas de bajo peso molecular degradadoras de la proteina mdm2.
EP3863636A1 (fr) 2018-10-08 2021-08-18 Revolution Medicines, Inc. Compositions d'inhibiteurs de shp2 destinées à être utilisées dans le traitement du cancer
EP3864165A4 (fr) 2018-10-09 2022-08-03 Genecentric Therapeutics, Inc. Détection d'une cellule cancéreuse d'origine
US20220411783A1 (en) 2018-10-12 2022-12-29 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
CA3116539C (fr) 2018-10-18 2023-10-03 Oklahoma Medical Research Foundation Biomarqueurs d'indice immunitaire d'activite de maladie du lupus erythemateux dissemine (sle) qui caracterise une activite de maladie
US20220111031A1 (en) 2018-10-22 2022-04-14 Evaxion Biotech Aps Vaccines targeting M. catharrhalis
JP2022508954A (ja) 2018-10-22 2022-01-19 ジェン-プローブ・インコーポレーテッド ヒトポリオーマウイルスbkウイルスを増幅、検出または定量化するための組成物および方法
IL262658A (en) 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
WO2020092140A2 (fr) 2018-11-02 2020-05-07 Insideoutbio, Inc. Méthodes et compositions d'induction ou de suppression de réponses immunitaires par l'utilisation de produits divisés de complément liés à une membrane
US20210395690A1 (en) 2018-11-08 2021-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anchorage-independent cells and use thereof
EP4357022A2 (fr) 2018-11-13 2024-04-24 The University of North Carolina at Chapel Hill Systèmes d'analyse avec dispositifs microfluidiques, dispositifs microfluidiques et procédés associés
WO2020104482A1 (fr) 2018-11-20 2020-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de prédiction de potentiel métastatique chez des patients souffrant de parapangliome à mutation dans sdhb
WO2020104943A2 (fr) 2018-11-20 2020-05-28 Janssen Biotech, Inc. Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique anti-il-23
CN113891934A (zh) 2018-11-21 2022-01-04 因达普塔治疗公司 扩增天然杀伤(nk)细胞子集的方法以及相关组合物和方法
IL263184A (en) 2018-11-21 2020-05-31 Yarden Yosef Method of treating cancer and compositions for same
AU2019389175A1 (en) 2018-11-30 2021-06-10 Caris Mpi, Inc. Next-generation molecular profiling
JP7478734B2 (ja) 2018-12-03 2024-05-07 エフ. ホフマン-ラ ロシュ アーゲー カンジダ・アウリス(candida auris)の検出のための組成物および方法
AU2019392735A1 (en) 2018-12-06 2021-06-17 Wageningen Universiteit Methods of genetically altering a plant NIN-gene to be responsive to cytokinin
US20220018853A1 (en) 2018-12-07 2022-01-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of gilz as a biomarker in sepsis
WO2020123508A2 (fr) 2018-12-10 2020-06-18 Amgen Inc. Constructions d'arni permettant d'inhiber l'expression de pnpla3 et leurs méthodes d'utilisation
WO2020123319A2 (fr) 2018-12-10 2020-06-18 10X Genomics, Inc. Procédés d'utilisation de réseaux maître/copie pour la détection spatiale
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
CN113286883A (zh) 2018-12-18 2021-08-20 格里尔公司 使用rna分析以检测疾病的方法
WO2020128864A1 (fr) 2018-12-18 2020-06-25 Janssen Biotech, Inc. Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23
WO2020128033A1 (fr) 2018-12-20 2020-06-25 Institut Pasteur Métabolisme cellulaire de l'ensemencement d'un réservoir de vih-1 dans des lymphocytes t cd4+
WO2020132607A1 (fr) 2018-12-20 2020-06-25 Life Technologies Corporation Colorant de rhodamine asymétrique et son utilisation dans des dosages biologiques
SG11202106124UA (en) 2018-12-20 2021-07-29 Life Technologies Corp Modified rhodamine dye and use thereof in biological assays
KR20210105947A (ko) 2018-12-20 2021-08-27 포세이다 테라퓨틱스, 인크. 나노트랜스포존 조성물 및 사용 방법
WO2020127620A1 (fr) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Détection d'acide nucléique cible par molographie en phase solide
CN113631709A (zh) 2018-12-20 2021-11-09 普拉克西斯精密药物股份有限公司 用于治疗kcnt1相关病症的组合物和方法
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
BR112021011571A2 (pt) 2018-12-26 2021-08-31 Janssen Pharmaceutica Nv Compostos de tienopiridinona
CA3125435A1 (fr) 2018-12-31 2020-07-09 Abbott Molecular Inc. Amplification amelioree d'acides nucleiques
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
EP3884071A4 (fr) 2019-01-03 2022-04-06 Boreal Genomics, Inc. Capture de cible liée
KR20210111262A (ko) 2019-01-03 2021-09-10 디엔에이 스크립트 올리고뉴클레오티드 세트의 원 포트 합성
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3126148A1 (fr) 2019-01-10 2020-07-16 Travera LLC Etalonnage d'un instrument de biomarqueur fonctionnel
US20220153827A1 (en) 2019-01-15 2022-05-19 Janssen Biotech, Inc. Anti-TNF Antibody Compositions and Methods for the Treatment of Juvenile Idiopathic Arthritis
AU2020208190B2 (en) 2019-01-15 2022-07-28 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
SG11202107670TA (en) 2019-01-18 2021-08-30 Univ California Dna methylation measurement for mammals based on conserved loci
ES2954675T3 (es) 2019-01-22 2023-11-23 Vipergen Aps Un método de cribado de una biblioteca de presentación in vitro dentro de una célula
EP3914698A1 (fr) 2019-01-23 2021-12-01 Yeda Research and Development Co. Ltd Milieux de culture pour cellules souches pluripotentes
US20220064278A1 (en) 2019-01-23 2022-03-03 Janssen Biotech, Inc. Anti-TNF Antibody Compositions for Use in Methods for the Treatment of Psoriatic Arthritis
WO2020185312A2 (fr) 2019-01-25 2020-09-17 President And Fellows Of Harvard College Compositions et procédé de synthèse d'acides nucléiques
JP2020117502A (ja) 2019-01-28 2020-08-06 ファイザー・インク 変形性関節症の徴候および症状を処置する方法
EP3923974A4 (fr) 2019-02-06 2023-02-08 Synthorx, Inc. Conjugués d'il-2 et méthodes d'utilisation de ceux-ci
IL264768A (en) 2019-02-10 2020-08-31 Sagi Irit ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use
IL264854A (en) 2019-02-14 2020-08-31 Bahat Anat Spt5 inhibitors and methods of use thereof
EP3924485A1 (fr) 2019-02-14 2021-12-22 DuPont Nutrition Biosciences ApS Bactérie lactique avec réduction de la sensibilité aux bactériophages de type cos
EP3927430A1 (fr) 2019-02-18 2021-12-29 Pfizer Inc. Procédé de traitement de la lombalgie chronique
WO2020172164A1 (fr) 2019-02-19 2020-08-27 Sequenom, Inc. Compositions, procédés et systèmes pour détecter un état de transplantation de cellules souches hématopoïétiques
WO2020171889A1 (fr) 2019-02-19 2020-08-27 University Of Rochester Blocage de l'accumulation des lipides ou de l'inflammation dans la maladie oculaire thyroïdienne
WO2020170239A1 (fr) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés de génération d'organoïdes pour criblage à haut rendement de médicaments
WO2020170240A1 (fr) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédé de réduction d'une néphrotoxicité induite par des médicaments
WO2020174044A1 (fr) 2019-02-27 2020-09-03 Evaxion Biotech Aps Vaccins ciblant h. influenzae
KR20210120127A (ko) 2019-02-27 2021-10-06 주식회사 씨젠 광모듈
EP3931354A1 (fr) 2019-02-28 2022-01-05 10X Genomics, Inc. Profilage d'analytes biologiques avec des réseaux d'oligonucléotides à codes-barres spatiaux
EP3837365A1 (fr) 2019-03-01 2021-06-23 Illumina, Inc. Banques de noyaux uniques et à cellule unique à haut rendement et leurs procédés de production et d'utilisation
US20200283796A1 (en) 2019-03-05 2020-09-10 Massachusetts Institute Of Technology Dna launched rna replicon system (drep) and uses thereof
KR20210137499A (ko) 2019-03-05 2021-11-17 더 스테이트 오브 이스라엘, 미니스트리 오브 애그리컬처 & 루럴 디벨로프먼트, 애그리컬처럴 리서치 오거니제이션, (에이.알.오.), 볼카니 센터 게놈-편집 조류
CN113543773B (zh) 2019-03-08 2023-07-14 塔罗制药工业有限公司 稳定的局部用非诺多泮组合物
WO2020185790A1 (fr) 2019-03-10 2020-09-17 Ultima Genomics, Inc. Méthodes et systèmes d'appel de séquence
GB201903520D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
JP2022525145A (ja) 2019-03-14 2022-05-11 ヤンセン バイオテツク,インコーポレーテツド 抗il12/il23抗体組成物を生成するための製造方法
GB201903519D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
GB201903521D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd No title
WO2020185298A1 (fr) 2019-03-14 2020-09-17 Massachusetts Institute Of Technology Vecteurs du virus de l'herpès simplex (hsv-1) modifiés et leurs utilisations
US20220169974A1 (en) 2019-03-14 2022-06-02 Dupont Nutrition Biosciences Aps New lactic acid bacteria
JP2022525407A (ja) 2019-03-14 2022-05-13 ビオンド バイオロジクス リミテッド 低分子脱落遮断剤
US20220144934A1 (en) 2019-03-14 2022-05-12 Janssen Biotech, Inc. Methods for Producing Anti-TNF Antibody Compositions
CN113840838A (zh) 2019-03-14 2021-12-24 詹森生物科技公司 用于产生抗tnf抗体组合物的制造方法
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ, インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
WO2020183271A1 (fr) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Procédés de production de compositions d'anticorps anti-tnf
EP3938538A1 (fr) 2019-03-15 2022-01-19 10X Genomics, Inc. Méthodes d'utilisation de matrices spatiales pour le séquençage d'organismes unicellulaires
IL265486A (en) 2019-03-19 2020-09-30 Yeda Res & Dev Bistable type ii opsins and uses thereof
BR112021018680A2 (pt) 2019-03-21 2021-11-23 Univ Of Essex Enterprises Limited Métodos para aumentar a biomassa em uma planta através da estimulação da regeneração de rubp e transporte de elétrons
EP3887542A1 (fr) 2019-03-22 2021-10-06 10X Genomics, Inc. Analyse spatiale tridimensionnelle
EP4389916A2 (fr) 2019-03-22 2024-06-26 Gen-Probe Incorporated Compositions et procédés de détection de streptocoques du groupe a
EP3948290A4 (fr) 2019-03-26 2023-08-09 Dermtech, Inc. Nouveaux classificateurs de gènes et leurs utilisations pour des cancers de la peau
WO2020193769A1 (fr) 2019-03-27 2020-10-01 Diagenode S.A. Procédé et kit de séquençage à haut débit
EP3798318A1 (fr) 2019-09-30 2021-03-31 Diagenode S.A. Procédé et kit de séquençage à haut débit
WO2020194317A1 (fr) 2019-03-28 2020-10-01 Yeda Research And Development Co. Ltd. Méthode de traitement de troubles liés aux lipides
MA55486A (fr) 2019-03-29 2022-02-09 Janssen Pharmaceutica Nv Inhibiteurs de la tyrosine kinase fgfr pour le traitement du carcinome urothélial
CA3130460A1 (fr) 2019-03-29 2020-10-08 Anne Elizabeth O'HAGAN Inhibiteurs de tyrosine kinase fgfr pour le traitement du carcinome urothelial
US20220175807A1 (en) 2019-03-31 2022-06-09 Yeda Research And Development Co. Ltd. Anti-viral and anti-tumoral compounds
WO2020202162A1 (fr) 2019-04-03 2020-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Amorces pour pcr multiplex
WO2020205491A1 (fr) 2019-04-05 2020-10-08 Hygiena, Llc Séquences et leur utilisation pour la détection et la caractérisation du genre cronobacter
WO2020210420A1 (fr) 2019-04-09 2020-10-15 Sigma-Aldrich Co. Llc Réaction accélérée en chaîne par polymérase basée sur le thermocyclage activé par le chauffage par ondes millimétriques
US20200325472A1 (en) 2019-04-09 2020-10-15 Massachusetts Institute Of Technology Mutant subgenomic promoter library and uses thereof
WO2020212992A2 (fr) 2019-04-17 2020-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Marqueurs de méthylation de cellules cancéreuses et utilisation associée
WO2020215017A1 (fr) 2019-04-17 2020-10-22 Impossible Foods Inc. Substances et procédés pour la production de protéines
WO2020212580A1 (fr) 2019-04-17 2020-10-22 Igenomix, S.L. Méthodes améliorées de diagnostic précoce de léiomyomes utérins et de léiomyosarcomes
AU2020263580A1 (en) 2019-04-25 2021-11-18 Impossible Foods Inc. Strains and methods for production of heme-containing proteins
WO2020223121A1 (fr) 2019-04-30 2020-11-05 Dana-Farber Cancer Institute, Inc. Méthodes de traitement du cancer à l'aide de combinaisons d'agents anti-cx3cr1 et d'agents de blocage de points de contrôle immunitaires
SG11202111824UA (en) 2019-04-30 2021-11-29 Larimar Therapeutics Inc Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
IL266433B (en) 2019-05-02 2020-11-30 Sagi Irit Compositions comprising the propeptide of lysyl oxidase and uses thereof
EP3963102A1 (fr) 2019-05-02 2022-03-09 F. Hoffmann-La Roche AG Utilisation de ditp pour une amplification préférentielle/sélective d'arn par rapport à des cibles d'adn sur la base de la température de séparation de brin
CA3176696C (fr) 2019-05-03 2024-06-11 Gen-Probe Incorporated Systeme de transport de receptacle pour systeme analytique
CN113795596A (zh) 2019-05-07 2021-12-14 豪夫迈·罗氏有限公司 用于检测淋病奈瑟氏球菌的组合物和方法
WO2020225779A1 (fr) 2019-05-09 2020-11-12 Istituto Pasteur Italia - Fondazione Cenci Bolognetti Agonistes de rig-i pour le traitement du cancer et l'immunothérapie
WO2020230133A1 (fr) 2019-05-13 2020-11-19 Yeda Research And Development Co. Ltd. Biomarqueurs de micro-adn acellulaire pour le pronostic et le diagnostic de maladies neurodégénératives
WO2020232319A1 (fr) 2019-05-15 2020-11-19 Insideoutbio, Inc. Agents thérapeutiques modulaires pour le traitement de maladies inflammatoires et du cancer
US20200362345A1 (en) 2019-05-17 2020-11-19 Massachusetts Institute Of Technology Engineered post-poly a signal rna and uses thereof
IL266728B (en) 2019-05-19 2020-11-30 Yeda Res & Dev Identification of recurrent mutant neopeptides
JP2022533745A (ja) 2019-05-22 2022-07-25 ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド ヒト多能性細胞を培養する方法
EP3972690A4 (fr) 2019-05-23 2023-07-05 Janssen Biotech, Inc. Méthode de traitement de maladie intestinale inflammatoire au moyen d'une polythérapie d'anticorps dirigés contre il -23 et tnf alpha
WO2020243579A1 (fr) 2019-05-30 2020-12-03 10X Genomics, Inc. Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique
BR112021024080A2 (pt) 2019-05-30 2022-02-08 Amgen Inc Construtos de rnai para inibir a expressão de scap e métodos de uso dos mesmos
US20220228988A1 (en) 2019-05-31 2022-07-21 Seegene, Inc. Device and method for detecting light
WO2020245677A1 (fr) 2019-06-03 2020-12-10 Janssen Biotech, Inc. Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active
WO2020245676A1 (fr) 2019-06-03 2020-12-10 Janssen Biotech, Inc. Compositions d'anticorps anti-tnf et méthodes pour le traitement de l'arthrite psoriasique
CA3142662A1 (fr) 2019-06-06 2020-12-10 Sitokine Limited Compositions et methodes de traitement des carcinomes pulmonaires, colorectaux et mammaires
IT201900008376A1 (it) 2019-06-07 2020-12-07 Univ Degli Studi Di Modena E Reggio Emilia Anticorpi ad attività antitumorale
CA3141414A1 (fr) 2019-06-12 2020-12-17 Vanderbilt University Dibenzylamines utilisables comme inhibiteurs du transport des acides amines
EP3983084A1 (fr) 2019-06-12 2022-04-20 Vanderbilt University Inhibiteurs de transport d'acides aminés et utilisations associées
JP2022536326A (ja) 2019-06-12 2022-08-15 ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド オリゴデンドロサイトの産生方法
BR112021024853A2 (pt) 2019-06-14 2022-01-18 Seegene Inc Método implementado por computador para o desenvolvimento colaborativo de reagentes para a detecção de ácidos nucleicos-alvo
WO2020249769A1 (fr) 2019-06-14 2020-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pour le traitement de maladies oculaires associées à la maintenance d'adn mitochondrial
JP2022538784A (ja) 2019-06-14 2022-09-06 ザ スクリプス リサーチ インスティテュート 半合成生物における複製、転写および翻訳のための試薬ならびに方法
EP3983540A1 (fr) 2019-06-16 2022-04-20 Yeda Research and Development Co. Ltd Méthode de stabilisation de l'arn intracellulaire
WO2020255008A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (hbv) et d'arni ciblant le hbv
WO2020263399A1 (fr) 2019-06-26 2020-12-30 Massachusetts Institute Of Technology Complexes protéine de fusion-hydroxyde métallique immunomodulateurs et leurs procédés
WO2020261281A1 (fr) 2019-06-27 2020-12-30 Ramot At Tel-Aviv University Ltd. Anticorps semaphorine 3a et leurs utilisations
US20220380756A1 (en) * 2019-06-28 2022-12-01 Asc Therapeutics Inc. Methods and compositions for treating thalassemia or sickle cell disease
CN114938647A (zh) 2019-07-04 2022-08-23 乌科公司 去表位的α-麦醇溶蛋白及其在乳糜泻和麸质敏感性管理中的用途
JP2022540083A (ja) 2019-07-08 2022-09-14 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムを破壊するための抗体組成物
KR20220044284A (ko) 2019-07-11 2022-04-07 카 메디컬 리미티드 이종이량체 및 이의 사용방법
US20230137971A1 (en) 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
IL268111A (en) 2019-07-16 2021-01-31 Fainzilber Michael Methods of treating pain
US20220281960A1 (en) 2019-07-16 2022-09-08 Ramot At Tel-Aviv University Ltd. Compositions and methods for the treatment of tuberculosis
WO2021016062A1 (fr) 2019-07-19 2021-01-28 The Children's Hospital Of Philadelphia Récepteurs antigéniques chimériques contenant des domaines de liaison au glypicane 2
EP4004240B1 (fr) 2019-07-25 2024-03-13 F. Hoffmann-La Roche AG Compositions et procédés pour la détection du virus epstein-barr (ebv)
EP4004548A1 (fr) 2019-07-29 2022-06-01 Yeda Research and Development Co. Ltd Procédés de traitement et de diagnostic du cancer du poumon
US11572546B2 (en) 2019-07-29 2023-02-07 Ginkgo Bioworks, Inc. Methods and compositions involving promoters derived from Yarrowia lipolytica
WO2021019536A1 (fr) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Méthodes de régulation de la synthèse de cannabinoïdes chez la plante ou dans des cellules et plantes et cellules ainsi produites
WO2021022109A1 (fr) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. Compositions d'arni de la famille des serpines 2 (serpinf2) et leurs procedes d'utilisation
EP4007811A2 (fr) 2019-08-01 2022-06-08 Alnylam Pharmaceuticals, Inc. Compositions d'arni de carboxypeptidase b2 (cpb2) et leurs procédés d'utilisation
GB201911068D0 (en) 2019-08-02 2019-09-18 Univ Edinburgh Modified higher plants
CA3145892A1 (fr) 2019-08-02 2021-02-11 Martin C. JONIKAS Motifs proteiques de liaison a rubisco et leurs utilisations
WO2021028909A1 (fr) 2019-08-12 2021-02-18 Yeda Research And Development Co. Ltd. Test sanguin de réparation de l'adn pour prédire la réponse de patients atteints d'un cancer du poumon à une immunothérapie
BR112022002579A2 (pt) 2019-08-12 2022-06-14 Biond Biologics Ltd Anticorpos contra ilt2 e uso dos mesmos
WO2021028469A1 (fr) 2019-08-12 2021-02-18 Sitokine Limited Compositions et méthodes de traitement du syndrome de libération de cytokines et de neurotoxicité
CA3150758A1 (fr) 2019-08-13 2021-02-18 Amgen Inc. Constructions d'arni pour inhiber l'expression de slc30a8 et leurs procedes d'utilisation
EP4013870A1 (fr) 2019-08-13 2022-06-22 Alnylam Pharmaceuticals, Inc. Compositions d'agent d'arni à sous-unité de protéine ribosomale 25 (rps25) et leurs procédés d'utilisation
EP4375382A2 (fr) 2019-08-14 2024-05-29 Lavie Bio Ltd. Souches bactériennes ayant une activité fongicide, compositions les comprenant et leur utilisation
WO2021028752A1 (fr) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anticorps anti-tfn pour le traitement du diabète de type i
JP2022545675A (ja) 2019-08-19 2022-10-28 オーフス ウニベルシテット 微生物叢を認識および構築させるための改変菌体外多糖受容体
GB201911928D0 (en) 2019-08-20 2019-10-02 Otsuka Pharma Co Ltd Pharmaceutical compounds
US11788091B2 (en) 2019-08-21 2023-10-17 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
WO2021033176A1 (fr) 2019-08-22 2021-02-25 Ariel Scientific Innovations Ltd. Procédés mis à l'échelle de purification d'anticorps
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
WO2021038569A1 (fr) 2019-08-27 2021-03-04 Yeda Research And Development Co. Ltd. Traitement de la vaginose bactérienne
US11739382B2 (en) 2019-08-27 2023-08-29 Roche Molecular Systems, Inc. Compositions and methods for amplification and detection of hepatitis B virus RNA, including HBV RNA transcribed from cccDNA
US11447832B2 (en) 2019-08-30 2022-09-20 Life Technologies Corporation Compositions and methods for oncology precision assays
EP4025698A1 (fr) 2019-09-03 2022-07-13 Sana Biotechnology, Inc. Particules associées à cd24 et procédés associés et leurs utilisations
AU2020343334A1 (en) 2019-09-05 2022-04-07 Gen-Probe Incorporated Detection of Chlamydia trachomatis nucleic acid variants
WO2021046261A1 (fr) 2019-09-05 2021-03-11 Poseida Therapeutics, Inc. Compositions de cellules allogéniques et procédés d'utilisation
US20220280427A1 (en) 2019-09-06 2022-09-08 Generation Bio Co. Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof
WO2021048852A1 (fr) 2019-09-11 2021-03-18 Yeda Research And Development Co. Ltd. Méthodes de traitement du cancer du sein
US20220334129A1 (en) 2019-09-13 2022-10-20 Evaxion Biotech A/S Method for identifying T-cell epitopes
EP4028517A1 (fr) 2019-09-13 2022-07-20 Danisco US Inc. Variants thermostables de glucose isomérase
WO2021048381A1 (fr) 2019-09-13 2021-03-18 Evaxion Biotech Aps Procédé d'identification de peptides de liaison au cmh stable par spectrométrie de masse
EP4031649A4 (fr) 2019-09-17 2023-09-20 Longhorn Vaccines and Diagnostics, LLC Compositions multifonctionnelles pour collecter et transporter un matériau biologique
JP2022548881A (ja) 2019-09-18 2022-11-22 ノバルティス アーゲー Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與entpd2抗體之組合療法
CA3151579A1 (fr) 2019-09-23 2021-04-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Traitement de maladies genetiques caracterisees par des arnm instables
WO2021062037A1 (fr) 2019-09-24 2021-04-01 Auburn University Constructions de phage-peptides pour la stimulation d'une réponse immunitaire anticancéreuse contre cd47
IL269674B (en) 2019-09-25 2020-08-31 Roy Bar Ziv Assembling protein complexes on a chip
WO2021062092A1 (fr) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Arn fonctionnel trans-activé par déplacement de brin et ses utilisations
WO2021062096A1 (fr) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Portes logiques à base de microarn et leurs utilisations
GB201913921D0 (en) 2019-09-26 2019-11-13 Sentinel Oncology Ltd Pharmaceutical compounds
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
CA3155930A1 (fr) 2019-09-27 2021-04-01 Starkage Therapeutics Domaines de liaison a l'antigene associes a des cellules senescentes, anticorps et recepteurs antigeniques chimeriques les comprenant, et leurs utilisations
EP4038182A1 (fr) 2019-09-30 2022-08-10 Bioverativ Therapeutics Inc. Formulations de vecteur lentiviral
EP3798319A1 (fr) 2019-09-30 2021-03-31 Diagenode S.A. Procédé de diagnostic et/ou de séquençage amélioré et kit
EP3828283A1 (fr) 2019-11-28 2021-06-02 Diagenode S.A. Procédé et kit de séquençage améliorés
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
EP4041918A1 (fr) 2019-10-11 2022-08-17 Life Technologies Corporation Compositions et procédés pour évaluer des populations microbiennes
WO2021072031A1 (fr) 2019-10-11 2021-04-15 Insideoutbio, Inc. Procédés et compositions pour la fabrication et l'utilisation d'agents thérapeutiques codés par de l'adn circulaire dans des troubles génétiques et d'autres maladies
CN115175680A (zh) 2019-10-18 2022-10-11 加利福尼亚大学董事会 Plxdc激活剂及其用于治疗血管病症的用途
WO2021076346A1 (fr) 2019-10-18 2021-04-22 Pioneer Hi-Bred International, Inc. Événement de maïs dp-202216-6 et empilement dp-023211-2
WO2021076828A1 (fr) 2019-10-18 2021-04-22 Alnylam Pharmaceuticals, Inc. Compositions d'arni de membre de la famille des transporteurs de solutés et leurs procédés d'utilisation
EP4048793A1 (fr) 2019-10-22 2022-08-31 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant du complément c3 et leurs méthodes d'utilisation
IL270306A (en) 2019-10-30 2021-05-31 Yeda Res & Dev Prevention and treatment of pre-myeloid and myeloid malignancies
KR20220092561A (ko) 2019-10-31 2022-07-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 난소암 검출
EP4051695A1 (fr) 2019-10-31 2022-09-07 Yeda Research and Development Co., Ltd. Bactéries autotrophes génétiquement modifiées pour la conversion de co2 en matériaux organiques
MX2022004388A (es) 2019-11-01 2022-05-06 Alnylam Pharmaceuticals Inc Composiciones de agentes de arni de huntingtina (htt) y metodos de uso de las mismas.
WO2021089643A1 (fr) 2019-11-04 2021-05-14 Mirnax Biosens, S.L. Amorce inverse bivalente
EP3901286A1 (fr) 2020-04-24 2021-10-27 Mirnax Biosens, S.L. Amorce inverse bivalente
WO2021092145A1 (fr) 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Composition d'arni de la transthyrétine (ttr) et ses procédés d'utilisation pour le traitement ou la prévention de maladies oculaires associées à ttr
WO2021091611A1 (fr) 2019-11-08 2021-05-14 10X Genomics, Inc. Agents de capture d'analytes marqués spatialement pour le multiplexage d'analytes
EP4025711A2 (fr) 2019-11-08 2022-07-13 10X Genomics, Inc. Amélioration de la spécificité de la liaison d'un analyte
AU2020384953A1 (en) 2019-11-11 2022-06-23 Ibi-Ag Innovative Bio Insecticides Ltd. Insect control nanobodies and uses thereof
JP2023502038A (ja) 2019-11-13 2023-01-20 アルナイラム ファーマシューティカルズ, インコーポレイテッド アンギオテンシノーゲン(agt)関連障害を処置するための方法および組成物
CA3159392A1 (fr) 2019-11-14 2021-05-20 Gen-Probe Incorporated Compositions et procedes de capture d'acides nucleiques cibles
US20230022576A1 (en) 2019-11-19 2023-01-26 Protalix Ltd. Removal of constructs from transformed cells
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
IL270800A (en) 2019-11-20 2021-05-31 Yeda Res & Dev A method for treating Alzheimer's disease
US20220411880A1 (en) 2019-11-21 2022-12-29 Inserm (Institut National De La Santéet De La Recherche Médicale) Methods and compositions for diagnosing and treating chronic myelomonocytic leukemia (cmml)
JP2023502576A (ja) 2019-11-22 2023-01-25 ジェネレーション バイオ カンパニー イオン化可能な脂質およびそれらのナノ粒子組成物
AU2020387423A1 (en) 2019-11-22 2021-09-30 Illumina, Inc. Circulating RNA signatures specific to preeclampsia
WO2021102373A1 (fr) 2019-11-22 2021-05-27 Alnylam Pharmaceuticals, Inc. Compositions d'agent arni d'ataxine 3 (atxn3) et leurs procédés d'utilisation
JP2023504270A (ja) 2019-12-02 2023-02-02 カリス エムピーアイ インコーポレイテッド 汎がんのプラチナ反応予測子
EP4010489A1 (fr) 2019-12-04 2022-06-15 Illumina, Inc. Préparation de bibliothèques de séquençage d'adn pour la détection d'agents pathogènes d'adn dans le plasma
WO2021113644A1 (fr) 2019-12-05 2021-06-10 Multivir Inc. Combinaisons comprenant un activateur de lymphocytes t cd8+, un inhibiteur de point de contrôle immunitaire et une radiothérapie en vue d'obtenir des effets ciblés et abscopal pour le traitement du cancer
WO2021118976A1 (fr) 2019-12-09 2021-06-17 University Of Georgia Research Foundation, Inc. Protéines ag85 de m. tuberculosis et procédés d'utilisation
US20230050863A1 (en) 2019-12-09 2023-02-16 Roche Molecular Systems, Inc. Dicationic fluorescent dyes
WO2021119402A1 (fr) 2019-12-12 2021-06-17 President And Fellows Of Harvard College Compositions et méthodes pour le codage à barres biomoléculaire dirigé par la lumière
AU2020401286A1 (en) 2019-12-13 2022-06-23 Inspirna, Inc. Metal salts and uses thereof
WO2021118927A1 (fr) 2019-12-13 2021-06-17 Insideoutbio, Inc. Méthodes et compositions pour l'administration ciblée d'agents thérapeutiques par l'acide nucléique
WO2021119226A1 (fr) 2019-12-13 2021-06-17 Alnylam Pharmaceuticals, Inc. Agents et compositions d'arni ciblant c9orf72 - cadre de lecture ouvert 72 sur le chromosome 9 - humain et procédés d'utilisation
WO2021126734A1 (fr) 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Compositions d'arni du gène codant pour la protéine 3 contenant un domaine phospholipase de type patatine (pnpla3) et leurs méthodes d'utilisation
IL293926A (en) 2019-12-17 2022-08-01 Pfizer Antibodies unique to d47, pd-l1 and their uses
US20220356461A1 (en) 2019-12-19 2022-11-10 Illumina, Inc. High-throughput single-cell libraries and methods of making and of using
JP2023507083A (ja) 2019-12-19 2023-02-21 クイデル コーポレーション モノクローナル抗体融合物
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021123387A1 (fr) 2019-12-20 2021-06-24 Da Volterra Prédiction de manifestations cliniques d'une dysbiose de microbiote intestinal
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021127505A1 (fr) 2019-12-20 2021-06-24 Poseida Therapeutics, Inc. Compositions anti-muc1 et méthodes d'utilisation
WO2021130753A1 (fr) 2019-12-22 2021-07-01 Yeda Research And Development Co. Ltd. Diagnostic de la démence frontotemporale
IL271656A (en) 2019-12-22 2021-06-30 Yeda Res & Dev System and methods for identifying cells that have undergone genome editing
EP4219754B1 (fr) 2019-12-23 2024-05-15 10X Genomics, Inc. Procédés d'analyse spatiale à l'aide d'une ligature à matrice d'arn
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
EP4081532A1 (fr) 2019-12-23 2022-11-02 Abbott Laboratories Compositions et procédés de détection de picobirnavirus
US11060141B1 (en) 2019-12-23 2021-07-13 Stilla Technologies Multiplex drop-off digital polymerase chain reaction methods
JP2023508100A (ja) 2019-12-27 2023-02-28 エフ. ホフマン-ラ ロシュ エージー. メチシリン耐性黄色ブドウ球菌を検出するための組成物および方法
WO2021138325A1 (fr) 2019-12-30 2021-07-08 Abbott Laboratories Compositions et procédés pour la détection du bunyavirus
WO2021137231A1 (fr) 2019-12-31 2021-07-08 Kahr Medical Ltd. Procédés de culture de lymphocytes t avec un polypeptide de fusion 4-1bbl et leurs utilisations
WO2021137230A1 (fr) 2019-12-31 2021-07-08 Kahr Medical Ltd. Procédés de culture de lymphocytes t et leurs utilisations
WO2021136752A1 (fr) 2019-12-31 2021-07-08 F. Hoffmann-La Roche Ag Criblage par pcr quantitative de prophages inductibles à partir d'isolats bactériens
IL271778A (en) 2019-12-31 2021-06-30 Ichilov Tech Ltd Methods for treating atopic dermatitis
EP4084815A1 (fr) 2020-01-02 2022-11-09 Edity Therapeutics Ltd. Compositions et méthodes d'administration
EP4087593A1 (fr) 2020-01-06 2022-11-16 Evaxion Biotech A/S Vaccins ciblant neisseria gonorrhoeae
CN114929279A (zh) 2020-01-07 2022-08-19 锐新医药公司 Shp2抑制剂给药和治疗癌症的方法
IL272074A (en) 2020-01-15 2021-07-29 Immunity Pharma Ltd Peptide compounds and their use in methods of treating diseases
JP2023510395A (ja) 2020-01-16 2023-03-13 ディーエヌエイイー ダイアグノスティックス リミテッド 標的ポリヌクレオチドを単離するための組成物、キットおよび方法
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
JP2023511200A (ja) 2020-01-22 2023-03-16 ライフ テクノロジーズ コーポレーション 自己免疫疾患および免疫不全疾患における免疫レパートリーバイオマーカー
IL272194A (en) 2020-01-22 2021-07-29 Yeda Res & Dev Multi-target antibodies for use in the treatment of diseases
AU2021210669A1 (en) 2020-01-24 2022-08-18 Pfizer Inc. Anti-E-selectin antibodies, compositions and methods of use
WO2021152584A1 (fr) 2020-01-28 2021-08-05 Ariel Scientific Innovations Ltd. Procédés d'analyse de membranes cellulaires
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021152586A1 (fr) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Procédés d'analyse du microbiome, du profil d'immunoglobuline et de l'état physiologique
IL272390A (en) 2020-01-30 2021-08-31 Yeda Res & Dev Cancer treatment methods
IL272389A (en) 2020-01-30 2021-08-31 Yeda Res & Dev Kits containing antibodies to PD-L1 and their uses in therapy
EP4096647A1 (fr) 2020-01-30 2022-12-07 Yeda Research and Development Co. Ltd Traitement d'une maladie hépatique aiguë à l'aide d'inhibiteurs de tlr-mik
WO2021154941A1 (fr) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Compositions d'arni du composant c5 du complément destinées à être utilisées dans le traitement de la sclérose latérale amyotrophique (sla)
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
EP3859012A1 (fr) 2020-02-03 2021-08-04 Albert-Ludwigs-Universität Freiburg Procédés pour l'amplification d'adn génomique et la préparation de bibliothèques de séquençage
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
IL295500A (en) 2020-02-09 2022-10-01 Nlc Pharma Ltd Rapid detection test for sars-cov-2
IL272586A (en) 2020-02-10 2021-08-31 Yeda Res & Dev A method for cell cluster analysis
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
TW202140012A (zh) 2020-02-12 2021-11-01 比利時商健生藥品公司 用於治療尿路上皮癌的fgfr酪胺酸激酶抑制劑和抗pd1藥劑
CN115103678A (zh) 2020-02-12 2022-09-23 詹森药业有限公司 用于治疗高风险非肌层浸润性膀胱癌的fgfr酪氨酸激酶抑制剂
US20210254140A1 (en) 2020-02-17 2021-08-19 10X Genomics, Inc. Situ analysis of chromatin interaction
BR112022016324A2 (pt) 2020-02-18 2022-10-11 Alnylam Pharmaceuticals Inc Composições de irna de apolipoproteína c3 (apoc3) e métodos de uso das mesmas
CA3168202A1 (fr) 2020-02-21 2021-08-26 Felice Alessio BAVA Methodes et compositions pour dosage spatial in situ integre
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
AR121460A1 (es) 2020-02-28 2022-06-08 Cambridge Entpr Ltd Métodos, plantas y composiciones para superar la supresión de nutrientes de microrrizas
IL295964A (en) 2020-02-28 2022-10-01 Takeda Pharmaceuticals Co A method for producing natural killer cells from pluripotent stem cells
US20230103731A1 (en) 2020-03-02 2023-04-06 Tenaya Therapeutics, Inc. Gene vector control by cardiomyocyte-expressed micrornas
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
AU2021230341A1 (en) 2020-03-04 2022-10-27 Gen-Probe Incorporated Compositions and methods for detecting SARS-CoV-2 nucleic acid
EP4114469A1 (fr) 2020-03-04 2023-01-11 Poseida Therapeutics, Inc. Compositions et méthodes pour le traitement de troubles hépatiques métaboliques
WO2021178607A1 (fr) 2020-03-05 2021-09-10 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant c3 du complément et leurs procédés d'utilisation pour le traitement ou la prévention de maladies associées au composant c3 du complément
WO2021176099A1 (fr) 2020-03-05 2021-09-10 Institut Pasteur Procédés et réactifs pour la détection spécifique et sensible du sras-cov-2
EP4114948A1 (fr) 2020-03-06 2023-01-11 Alnylam Pharmaceuticals, Inc. Compositions d'arni de cétohexokinase (khk) et leurs procédés d'utilisation
EP4118239A1 (fr) 2020-03-09 2023-01-18 F. Hoffmann-La Roche AG Compositions et méthodes de détection du coronavirus 2 du syndrome respiratoire aigu sévère (sras-cov-2), de la grippe a et de la grippe b
CA3174908A1 (fr) 2020-03-09 2021-09-16 Pfizer Inc. Proteines de fusion et leurs utilisations
IL296319A (en) 2020-03-09 2022-11-01 Janssen Biotech Inc Compositions and Methods for Quantifying Recombinant Vector Nucleic Acid Incorporation
WO2021181388A1 (fr) 2020-03-09 2021-09-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthodes de diagnostic et de traitement du cancer mutant p53
EP4118107A1 (fr) 2020-03-11 2023-01-18 Poseida Therapeutics, Inc. Récepteurs stimulateurs chimériques et procédés d'utilisation dans l'activation et la différenciation de lymphocytes t
WO2021186431A1 (fr) 2020-03-16 2021-09-23 Yeda Research And Development Co. Ltd. Analogues peptidiques et leur utilisation dans le traitement de maladies, troubles ou états associés à une protéine p53 mutante
EP4121534A1 (fr) 2020-03-18 2023-01-25 Alnylam Pharmaceuticals, Inc. Compositions et méthodes pour traiter des sujets ayant un variant de gène d'alanine-glyoxylate aminotransférase hétérozygote (agxt)
JP2023520764A (ja) 2020-03-24 2023-05-19 ジェネレーション バイオ カンパニー 第ix因子治療薬を発現するための非ウイルス性dnaベクター及びその使用
IL296662A (en) 2020-03-24 2022-11-01 Generation Bio Co Non-viral DNA vectors and their use for expression of Gauche cure
EP4127148A1 (fr) 2020-03-25 2023-02-08 Erasmus University Rotterdam Medical Center Système rapporteur pour imagerie de radionucléides
WO2021195307A1 (fr) 2020-03-26 2021-09-30 Alnylam Pharmaceuticals, Inc. Compositions d'arni de coronavirus et leurs procédés d'utilisation
EP4126226A1 (fr) 2020-03-29 2023-02-08 Yeda Research and Development Co. Ltd Variants de bêta-glucocérébrosidase destinés à être utilisés dans le traitement de la maladie de gaucher
US20230287505A1 (en) 2020-03-30 2023-09-14 Rophelbio Co., Ltd. Biomarker for cancer immunotherapy and use thereof
CN115484836A (zh) 2020-03-31 2022-12-16 百欧穆斯有限公司 用于预防和治疗烟雾诱发的肺部损伤的细菌
JP2023521663A (ja) 2020-03-31 2023-05-25 サナ バイオテクノロジー,インコーポレイテッド 標的化脂質粒子及び組成物ならびにその使用
US11149320B1 (en) 2020-03-31 2021-10-19 Diasorin S.P.A. Assays for the detection of SARS-CoV-2
WO2021205444A1 (fr) 2020-04-06 2021-10-14 Yeda Research And Development Co. Ltd. Méthodes de diagnostic du cancer et de prédiction de la réactivité à une thérapie
WO2021205453A1 (fr) 2020-04-07 2021-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés de détection d'acide nucléique
IT202000007357A1 (it) 2020-04-07 2021-10-07 Elitechgroup S P A Metodo per il rilevamento e la quantificazione di citomegalovirus umano attraverso RNA virionici.
EP4132479A1 (fr) 2020-04-07 2023-02-15 Ramot at Tel-Aviv University Ltd. Compositions contenant du cannabidiol et leurs utilisations
WO2021206922A1 (fr) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. Compositions d'arni de la serine protease 2 transmembranaire (tmprss2) et leurs procédés d'utilisation
WO2021206917A1 (fr) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. Compositions arni d'enzyme de conversion de l'angiotensine 2 (eca2) et procédés d'utilisation associés
WO2021205325A1 (fr) 2020-04-08 2021-10-14 Pfizer Inc. Anticorps anti-gucy2c et leurs utilisations
WO2021205013A1 (fr) 2020-04-09 2021-10-14 Sitokine Limited Compositions et méthodes de traitement de la covid-19
WO2021209993A1 (fr) 2020-04-13 2021-10-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Utilisation de régulateurs métaboliques pour le traitement de la covid-19
CN115666619A (zh) 2020-04-13 2023-01-31 埃索普罗瑟医疗有限公司 用于抗病毒治疗的包含野生型p53蛋白的细胞衍生囊泡
IL297025A (en) 2020-04-14 2022-12-01 Poseida Therapeutics Inc Preparations and methods for use in cancer treatment
US20210322483A1 (en) 2020-04-16 2021-10-21 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
US20230149536A1 (en) 2020-04-17 2023-05-18 Vyriad, Inc. Compositions for treating and/or preventing coronavirus infections
CA3180508A1 (fr) 2020-04-17 2021-10-21 Regeneron Pharmaceuticals, Inc. Dosages de detection pour des anticorps neutralisant le coronavirus
CN116368221A (zh) 2020-04-22 2023-06-30 因达普塔治疗公司 自然杀伤(nk)细胞组合物及其生成方法
EP4139485B1 (fr) 2020-04-22 2023-09-06 10X Genomics, Inc. Procédés d'analyse spatiale utilisant un appauvrissement d'arn ciblée
US11702689B2 (en) 2020-04-24 2023-07-18 Microsoft Technology Licensing, Llc Homopolymer primers for amplification of polynucleotides created by enzymatic synthesis
WO2021222065A1 (fr) 2020-04-27 2021-11-04 Alnylam Pharmaceuticals, Inc. Compositions d'agent d'arni de l'apolipoprotéine e (apoe) et leurs procédés d'utilisation
US20230235379A1 (en) 2020-04-30 2023-07-27 Dimensiongen Devices and methods for macromolecular manipulation
BR112022021136A2 (pt) 2020-04-30 2022-11-29 Alnylam Pharmaceuticals Inc Composições de irna de fator b de complemento (cfb) e métodos de uso das mesmas
AU2021265602A1 (en) 2020-05-01 2023-01-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. E protein channel blockers and ORF3 inhibitors as anti-covid-19 agents
WO2022113069A1 (fr) 2020-11-24 2022-06-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Bloqueurs de canal de la protéine e et inhibiteurs de l'orf3 utilisés en tant qu'agents anti-covid-19
US11739359B2 (en) 2020-05-01 2023-08-29 Microsoft Technology Licensing, Llc Universal template strands for enzymatic polynucleotide synthesis
EP4146821A1 (fr) 2020-05-07 2023-03-15 Grifols Diagnostic Solutions Inc. Procédés et compositions pour la détection d'acide nucléique sras-cov-2
EP3907301A1 (fr) 2020-05-08 2021-11-10 Istituto Europeo di Oncologia S.r.l. Méthodes et trousses pour déterminer le risque de récurrence du cancer du sein
EP3909601A1 (fr) 2020-05-11 2021-11-17 LeukoCom GmbH Nouvel anticorps se liant spécifiquement au ceacam 1/3/5 humain et son utilisation
WO2021229577A1 (fr) 2020-05-12 2021-11-18 Collplant Ltd. Collagène utilisé comme outil d'administration d'agents antiviraux à base de métaux
EP4150077A1 (fr) 2020-05-15 2023-03-22 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar de la protéine 1 de type canal transmembranaire (tmc1)
WO2021231698A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar d'argininosuccinate lyase (asl)
WO2021231675A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar d'argininosuccinate synthétase (ass1)
EP4150076A1 (fr) 2020-05-15 2023-03-22 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar de la protéine 2 de liaison méthyl-cpg (mecp2)
WO2021231673A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar de la kinase 2 à répétition riche en leucine (lrrk2)
WO2021231692A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar d'otoferline (otof)
WO2021231679A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar de la protéine bêta 2 de jonction lacunaire (gjb2)
WO2021231691A1 (fr) 2020-05-15 2021-11-18 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar de rétinoschisine 1 (rs1)
EP4153192A1 (fr) 2020-05-19 2023-03-29 Institut Curie Méthodes de diagnostic et de traitement du syndrome de libération de cytokines
BR112022023269A2 (pt) 2020-05-19 2022-12-20 Univ Aarhus Motivos do receptor de lysm
US10941453B1 (en) 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
US20230190871A1 (en) 2020-05-20 2023-06-22 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
IL274811B (en) 2020-05-20 2021-05-31 Yeda Res & Dev Spatial information is developed for the analysis of individual cells
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (fr) 2020-05-22 2023-03-29 10X Genomics, Inc. Mesure spatio-temporelle simultanée de l'expression génique et de l'activité cellulaire
WO2021242834A1 (fr) 2020-05-26 2021-12-02 10X Genomics, Inc. Procédé de réinitialisation d'un réseau
WO2021243203A1 (fr) 2020-05-29 2021-12-02 FUJIFILM Cellular Dynamics, Inc. Bicouche d'épithélium pigmentaire rétinien et de photorécepteurs et son utilisation
WO2021243256A1 (fr) 2020-05-29 2021-12-02 FUJIFILM Cellular Dynamics, Inc. Agrégats cellulaires doubles de photorécepteurs et d'épithélium pigmenté rétinien et leurs procédés d'utilisation
CN116234907A (zh) 2020-06-01 2023-06-06 美国安进公司 用于抑制hsd17b13表达的rnai构建体及其使用方法
EP4158054A1 (fr) 2020-06-02 2023-04-05 10X Genomics, Inc. Trancriptomique spatiale pour les récepteurs d'antigènes
WO2021247543A2 (fr) 2020-06-02 2021-12-09 10X Genomics, Inc. Procédés de banques d'acides nucléiques
AR122534A1 (es) 2020-06-03 2022-09-21 Triplet Therapeutics Inc Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
EP4161653A1 (fr) 2020-06-03 2023-04-12 Bionecure Therapeutics, Inc. Anticorps de l'antigène 2 de surface cellulaire du trophoblaste (trop-2)
KR20230007464A (ko) 2020-06-05 2023-01-12 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
WO2021252499A1 (fr) 2020-06-08 2021-12-16 10X Genomics, Inc. Méthodes de détermination de marge chirurgicale et méthodes d'utilisation associées
EP4162050A1 (fr) 2020-06-09 2023-04-12 Alnylam Pharmaceuticals, Inc. Compositions d'arni et leurs procédés d'utilisation pour une administration par inhalation
WO2021252617A1 (fr) 2020-06-09 2021-12-16 Illumina, Inc. Procédés pour augmenter le rendement de bibliothèques de séquençage
WO2021252574A1 (fr) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Biomarqueurs d'acide nucléique pour un dysfonctionnement placentaire
EP4165207A1 (fr) 2020-06-10 2023-04-19 10X Genomics, Inc. Procédés de détermination d'un emplacement d'un analyte dans un échantillon biologique
US11952637B2 (en) 2020-06-12 2024-04-09 Arizona Board Of Regents On Behalf Of Arizona State University Rapid low-cost detection of SARS-CoV-2 using isothermal amplification and sensing methods
MX2022015149A (es) 2020-06-18 2023-01-11 Alnylam Pharmaceuticals Inc Composiciones de acido ribonucleico de interferencia (arni) de xantina dehidrogenasa (xdh) y metodos de uso de las mismas.
WO2021260675A1 (fr) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents pour sensibiliser des tumeurs solides à un traitement
WO2021263111A1 (fr) 2020-06-25 2021-12-30 10X Genomics, Inc. Analyse spatiale de la méthylation de l'adn
CN115989415A (zh) 2020-06-30 2023-04-18 健肺生命人工智能公司 用于检测肺癌的方法
EP4176050A1 (fr) 2020-07-03 2023-05-10 enGenes Biotech GmbH Variants de pyrrolysyl-arnt synthétase et leurs utilisations
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US20230249178A1 (en) 2020-07-08 2023-08-10 Roche Sequencing Solutions, Inc. Split-pool synthesis apparatus and methods of performing split-pool synthesis
CN111534576B (zh) 2020-07-08 2020-10-02 圣湘生物科技股份有限公司 用于荧光定量pcr的方法、组合物、试剂盒及其用途
JP2023533271A (ja) 2020-07-08 2023-08-02 エフ. ホフマン-ラ ロシュ アーゲー 次世代シーケンシングライブラリーの標的捕捉中の、ポイズンプライマーを使用した非標的ライブラリー分子の標的化された枯渇
US20240018524A1 (en) 2020-07-10 2024-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating epilepsy
WO2022013874A1 (fr) 2020-07-14 2022-01-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composition comprenant des cannabinoïdes, des terpènes et des flavonoïdes pour le traitement de la dépression
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
PE20231565A1 (es) 2020-07-17 2023-10-04 Pfizer Anticuerpos terapeuticos y sus usos
CA3188657A1 (fr) 2020-07-17 2022-01-20 Gen-Probe Incorporated Detection du mycoplasma genitalium resistant aux macrolides
EP4182458A2 (fr) 2020-07-20 2023-05-24 Dana-Farber Cancer Institute, Inc. Méthodes et compositions pour le traitement et la prévention d'une infection par un coronavirus
CA3185197A1 (fr) 2020-07-21 2022-01-27 Allogene Therapeutics, Inc. Recepteurs antigeniques chimeriques a activites et signalisations ameliorees et leurs utilisations
CA3186950A1 (fr) 2020-07-23 2022-01-27 Scott Benson Compositions, systemes et methodes d'analyse biologique impliquant des conjugues de colorants a transfert d'energie et analytes comprenant ceux-ci
EP4185596A1 (fr) 2020-07-23 2023-05-31 Life Technologies Corporation Conjugués de colorant de transfert d'énergie destinés à être utilisés dans des dosages biologiques
EP4189093A1 (fr) 2020-07-30 2023-06-07 Pfizer Inc. Cellules ayant des duplications de gènes et leurs utilisations
WO2022022662A1 (fr) 2020-07-31 2022-02-03 百奥泰生物制药股份有限公司 Anticorps contre le cd47 et son application
IL276599A (en) 2020-08-09 2022-03-01 Yeda Res & Dev T cell receptor unique to mage-a1 and its uses
IL276627A (en) 2020-08-10 2022-03-01 Yeda Res & Dev Compositions for diagnosis and treatment of coronavirus infections
TW202221035A (zh) 2020-08-12 2022-06-01 以色列商拜恩德生物製品有限公司 抗ilt2抗體及其用途
CA3190414A1 (fr) 2020-08-12 2022-02-17 Phylos Bioscience, Inc. Marqueurs de varine
WO2022038536A1 (fr) 2020-08-18 2022-02-24 International Rice Research Institute Procédés d'augmentation des taux de croisement de gramineae
US20230357852A1 (en) 2020-08-19 2023-11-09 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
CA3181715A1 (fr) 2020-08-27 2022-03-03 Otsuka Pharmaceutical Co., Ltd. Biomarqueurs pour la therapie anticancereuse utilisant des antagonistes de mdm2
US20230303665A1 (en) 2020-08-28 2023-09-28 Sana Biotechnology, Inc. Modified anti-viral binding agents
WO2022047359A1 (fr) 2020-08-31 2022-03-03 Berg Llc Biomarqueurs protéiques du cancer du pancréas
CA3194028A1 (fr) 2020-09-04 2022-03-10 Cardio Diagnostics, Inc. Methodes et compositions visant a predire et/ou a surveiller une maladie cardiovasculaire et traitements associes
CN116669763A (zh) 2020-09-14 2023-08-29 詹森药业有限公司 Fgfr抑制剂联合疗法
EP3971303A1 (fr) 2020-09-21 2022-03-23 ETH Zurich Porte-échantillon métallique, sonde pour réaliser des réactions de détection et appareil pour recevoir le porte-échantillon
IL277488A (en) 2020-09-21 2022-04-01 Yeda Res & Dev Weight regulation method
IL301503A (en) 2020-09-23 2023-05-01 Yeda res & development co ltd Methods and preparations for the treatment of the disease caused by the corona virus
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
EP4217489A1 (fr) 2020-09-24 2023-08-02 Alnylam Pharmaceuticals, Inc. Compositions d'arni de dipeptidyle peptidase 4 (dpp4) et leurs procédés d'utilisation
GB202015187D0 (en) 2020-09-25 2020-11-11 Sentinel Oncology Ltd A pharmaceutical salt
IL277743A (en) 2020-10-01 2022-04-01 Yeda Res & Dev A method for diagnosing breast cancer
GB202015772D0 (en) 2020-10-05 2020-11-18 Univ Newcastle Pngase enzymes
EP4225902A1 (fr) 2020-10-05 2023-08-16 Protalix Ltd. Cellules végétales inactivées de type dicer
JP2023544413A (ja) 2020-10-05 2023-10-23 アルナイラム ファーマシューティカルズ, インコーポレイテッド Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
WO2022074656A1 (fr) 2020-10-07 2022-04-14 Protalix Ltd. Dnase à action prolongée
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
MX2023003929A (es) 2020-10-09 2023-06-22 Pfizer Anticuerpos cd1a y su uso.
US12006550B2 (en) 2020-10-12 2024-06-11 University Of South Carolina Targeting treatment for ADAM30 in pathological cells
CN116710571A (zh) 2020-10-15 2023-09-05 卡帕生物系统公司 用于下一代测序文库制备的电泳装置和方法
EP4228637A1 (fr) 2020-10-15 2023-08-23 Yeda Research and Development Co. Ltd Méthode de traitement des cancers myéloïdes
WO2022079224A1 (fr) 2020-10-15 2022-04-21 Institut Pasteur Méthodes et kits de détection de sars-cov-2
WO2022087148A1 (fr) 2020-10-21 2022-04-28 Poseida Therapeutics, Inc. Compositions et procédés d'administration d'acides nucléiques
US11730133B2 (en) 2020-10-21 2023-08-22 Equi-Nom Ltd High yield sesame
WO2022087257A2 (fr) 2020-10-21 2022-04-28 Gen-Probe Incorporated Système de gestion de conteneurs de fluide
EP4232582A1 (fr) 2020-10-23 2023-08-30 Alnylam Pharmaceuticals, Inc. Compositions d'arni de la mucine 5b (muc5b) et leurs méthodes d'utilisation
IL278401A (en) 2020-10-29 2022-05-01 Yeda Res & Dev Polynucleotides for editing RNA and a method for using them
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CA3194255A1 (fr) 2020-11-05 2022-05-12 Becton, Dickinson And Company Detection multiplex d'agents pathogenes respiratoires bacteriens
CN116964226A (zh) 2020-11-05 2023-10-27 贝克顿迪金森公司 副溶血弧菌的快速鉴定和分型
EP4240876A1 (fr) 2020-11-05 2023-09-13 Becton, Dickinson and Company Détection multiplex et typage de vibrio cholerae
US20230416750A1 (en) 2020-11-09 2023-12-28 1E Therapeutics Ltd. Catalytic sequence based methods of treating or preventing bacterial infections
AU2021380809A1 (en) 2020-11-13 2023-06-22 Alnylam Pharmaceuticals, Inc. COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2022104391A1 (fr) 2020-11-16 2022-05-19 Life Technologies Corporation Compositions et procédés pour le suivi du répertoire immunitaire
EP4247976A1 (fr) 2020-11-17 2023-09-27 Life Technologies Corporation Compositions et procédés pour la supervision du répertoire immunitaire
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022112284A1 (fr) 2020-11-25 2022-06-02 Dupont Nutrition Biosciences Aps Bactérie présentant une sensibilité réduite au bactériophages
JP2023550979A (ja) 2020-11-26 2023-12-06 ウッコ インコーポレイテッド 改変された高分子量グルテニンサブユニット及びその使用
EP4256053A1 (fr) 2020-12-01 2023-10-11 Alnylam Pharmaceuticals, Inc. Méthodes et compositions pour l'inhibition de l'expression du gène de l'hao1 (hydroxyacide oxydase 1 (glycolate oxydase))
WO2022120019A2 (fr) 2020-12-02 2022-06-09 Massachusetts Institute Of Technology Régulateur de rétroaction basé sur une phosphorylation adaptable de l'expression génique de mammifères
JP2023552546A (ja) 2020-12-04 2023-12-18 エフ. ホフマン-ラ ロシュ アーゲー マラリアを検出するための組成物および方法
WO2022125490A1 (fr) 2020-12-08 2022-06-16 Alnylam Pharmaceuticals, Inc. Compositions d'arni du facteur de coagulation x (f10) et leurs méthodes d'utilisation
EP4012046A1 (fr) 2020-12-11 2022-06-15 10X Genomics, Inc. Procédés et compositions pour l'analyse multimodale in situ
IL279559A (en) 2020-12-17 2022-07-01 Yeda Res & Dev Controlling the ubiquitination process of mlkl for disease treatment
WO2022140028A1 (fr) 2020-12-21 2022-06-30 10X Genomics, Inc. Procédés, compositions et systèmes pour capturer des sondes et/ou des codes à barres
AU2021409801A1 (en) 2020-12-21 2023-06-22 Allogene Therapeutics, Inc. Protease-activating cd45-gate car
WO2022136477A1 (fr) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Procédés pour réaliser une pcr multiplex en temps réel avec utilisation de colorants fluorescents à grand déplacement de stokes
EP4267760A1 (fr) 2020-12-23 2023-11-01 10X Genomics, Inc. Procédés et compositions pour une détection d'analyte
WO2022140793A1 (fr) 2020-12-24 2022-06-30 Life Technologies Corporation Compositions et procédés de détection hautement sensible de séquences cibles dans des réactions multiplex
CA3206360A1 (fr) 2020-12-24 2022-06-30 Integrated Dna Technologies, Inc. Mutants de rnase h2 reduisant les dimeres d'amorce et l'amplification hors cible dans le sequencage d'amplicon base sur la rhpcr avec des polymerases d'adn haute fidelite
EP4267742A2 (fr) 2020-12-28 2023-11-01 1E Therapeutics, Ltd. Arnm de p21 ciblant des dnazymes
EP4267741A2 (fr) 2020-12-28 2023-11-01 1E Therapeutics, Ltd. Zones cibles de l'arnm p21 pour le silençage
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4271834A1 (fr) 2020-12-31 2023-11-08 Ingénierie et Analyse en Génétique Environnementale Détection de pathogènes dans une matrice liquide
WO2022147468A1 (fr) 2020-12-31 2022-07-07 Tempus Labs, Inc. Systèmes et procédés de détection de biomarqueurs multimoléculaires
WO2022144903A1 (fr) 2021-01-03 2022-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Diagnostic de mutations conductrices du cancer
EP4274896A1 (fr) 2021-01-05 2023-11-15 Alnylam Pharmaceuticals, Inc. Compositions d'arni du composant du complément 9 (c9) et leurs méthodes d'utilisation
JP2024502377A (ja) 2021-01-10 2024-01-18 スーパーミート ザ エッセンス オブ ミート リミテッド 培養肉産業用の多能性幹細胞凝集体及びそれから得られる微小組織
US20240083843A1 (en) 2021-01-14 2024-03-14 Yeda Research And Development Co. Ltd. Methods of producing vitamin d
EP4277658A1 (fr) 2021-01-15 2023-11-22 Board of Regents, The University of Texas System Système de trans-complémentation pour le sars-cov-2
MX2023008604A (es) 2021-01-21 2023-10-10 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Nanopartículas de arni y métodos de uso de las mismas en agricultura.
IL280340B (en) 2021-01-21 2022-04-01 Yeda Res & Dev Antibodies, peptides and their combinations for the treatment and prevention of corona virus infections
WO2022159874A1 (fr) 2021-01-25 2022-07-28 Life Technologies Corporation Compositions, kits et méthodes de détection de séquences de variants viraux
US20220235403A1 (en) 2021-01-26 2022-07-28 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
EP4284947A1 (fr) 2021-01-29 2023-12-06 Institut National de la Santé et de la Recherche Médicale (INSERM) Procedes d'évaluation du risque de développement d'une leuco-entéphalopathie multifocale progressive chez les patients traités par des antagonistes de la vla-4
WO2022165233A1 (fr) 2021-01-29 2022-08-04 Allogene Therapeutics, Inc. INACTIVATION OU INVALIDATION D'UN OU PLUSIEURS PARMI TAP2, NLRC5, β2M, TRAC, RFX5, RFXAP ET RFXANK POUR ATTÉNUER LA RECONNAISSANCE PAR LES LYMPHOCYTES T DES PRODUITS DE CELLULES ALLOGÉNIQUES
CN116806268A (zh) 2021-02-05 2023-09-26 豪夫迈·罗氏有限公司 用于检测人副流感病毒1-4(hpiv 1-4)的组合物和方法
JP2024508088A (ja) 2021-02-09 2024-02-22 ユニバーシティ オブ ヒューストン システム 全身送達及び抗腫瘍活性の向上のための腫瘍溶解性ウイルス
WO2022171685A1 (fr) 2021-02-10 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Agent bloquant le tnf-alpha pour prévenir, soulager et/ou retarder l'apparition du diabète de type 1
BR112023015761A2 (pt) 2021-02-12 2023-11-07 Alnylam Pharmaceuticals Inc Superóxido dismutase 1 (sod1) composições de irna e métodos de uso das mesmas para tratar ou prevenir doenças neurodegenerativas associadas a superóxido dismutase 1 (sod1)
US20240132964A1 (en) 2021-02-17 2024-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale Methods of predicting multisystem inflammatory syndrome (mis-c) with severe myocarditis in subjects suffering from a sars-cov2 infection or disease severity following sars-cov-2 infection or myocarditis post-vaccination against sars-cov-2
IL305314A (en) 2021-02-18 2023-10-01 Yeda res & development co ltd A genetically engineered bacterium for vaccine production
CA3208982A1 (fr) 2021-02-18 2022-08-25 Ravid STRAUSSMAN Procede de generation de vaccins
AU2022223409A1 (en) 2021-02-19 2023-09-21 Theripion, Inc. Dnase fusion polypeptides and related compositions and methods
CA3208993A1 (fr) 2021-02-23 2022-09-01 Joshua RYCHAK Compositions et procedes d'administration d'acides nucleiques
US20240060090A1 (en) 2021-02-23 2024-02-22 Poseida Therapeutics, Inc. Genetically modified induced pluripotent stem cells and methods of use thereof
CN117222739A (zh) 2021-02-25 2023-12-12 阿尔尼拉姆医药品有限公司 朊病毒蛋白(prnp)irna组合物和其使用方法
IL305153A (en) 2021-02-26 2023-10-01 Alnylam Pharmaceuticals Inc Ketohexokinase (KHK) iRNA compositions and methods of using them
US20240083995A1 (en) 2021-03-02 2024-03-14 Laurie H. Glimcher Methods of treating red blood cell disorders
EP4301772A1 (fr) 2021-03-04 2024-01-10 Allogene Therapeutics, Inc. Expression de fasl et inactivation du gène fasr pour protéger les cellules thérapeutiques contre le rejet allogénique et la mort cellulaire induite par activation
IL305418A (en) 2021-03-04 2023-10-01 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
EP4301863A1 (fr) 2021-03-04 2024-01-10 Poseida Therapeutics, Inc. Compositions et méthodes de traitement de l'hémophilie
EP4305169A1 (fr) 2021-03-12 2024-01-17 Alnylam Pharmaceuticals, Inc. Compositions d'arni de la glycogène synthase kinase 3 alpha (gsk3a) et leurs procédés d'utilisation
AU2022233792A1 (en) 2021-03-12 2023-10-26 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
JP2024510588A (ja) 2021-03-12 2024-03-08 ヤンセン バイオテツク,インコーポレーテツド 抗il23特異的抗体による、tnf療法に対する不十分な応答を有する乾癬性関節炎患者を治療する方法
EP4308723A1 (fr) 2021-03-15 2024-01-24 F. Hoffmann-La Roche AG Séquençage ciblé de nouvelle génération par l'intermédiaire d'une extension d'amorce ancrée
US20240158834A1 (en) 2021-03-15 2024-05-16 Gen-Probe Incorporated Compositions and methods for biological sample processing
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
IL281561A (en) 2021-03-16 2022-10-01 Yeda Res & Dev Methods and devices for growing mouse embryos outside the uterus
AU2022238446A1 (en) 2021-03-18 2023-09-07 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2022195504A1 (fr) 2021-03-19 2022-09-22 Pfizer Inc. Méthode de traitement de la douleur due à l'arthrose avec un anticorps anti-ngf
WO2022203748A1 (fr) 2021-03-23 2022-09-29 Life Technologies Corporation Compositions, kits et procédés de détection de séquences virales cibles résistant à des variants
WO2022200485A1 (fr) 2021-03-26 2022-09-29 F. Hoffmann-La Roche Ag Formulations de tampons d'hybridation
CA3214499A1 (fr) 2021-03-29 2022-10-06 Alnylam Pharmaceuticals, Inc. Compositions d'agents d'arni de la huntingtine (htt) et leurs procedes d'utilisation
EP4313091A1 (fr) 2021-03-30 2024-02-07 Biomx Ltd. Bactériophage de pseudomonas et ses utilisations
AU2022252302A1 (en) 2021-03-31 2023-09-14 Illumina, Inc. Blocking oligonucleotides for the selective depletion of non-desirable fragments from amplified libraries
EP4314293A1 (fr) 2021-04-01 2024-02-07 Alnylam Pharmaceuticals, Inc. Compositions d'arni de proline déshydrogénase 2 (prodh2) et procédés d'utilisation associés
WO2022216841A1 (fr) 2021-04-06 2022-10-13 Berg Llc Marqueurs protéiques pour un cancer du sein positif au récepteur des œstrogènes (er) de type luminal a (la) et de type luminal b1 (lb1)
CA3214833A1 (fr) 2021-04-06 2022-10-13 Bpgbio, Inc. Marqueurs proteiques pour le pronostic de la progression du cancer du sein
WO2022216846A1 (fr) 2021-04-06 2022-10-13 Berg Llc Marqueurs protéiques pour le cancer du sein du type positif aux récepteurs des oestrogènes (er) et du type négatif aux récepteurs des oestrogènes (er)
IL282188A (en) 2021-04-08 2022-11-01 Yeda Res & Dev Combined use of ketamine and bretigabine for the treatment of psychiatric disorders
CA3214688A1 (fr) 2021-04-08 2022-10-13 Andrzej KROLEWSKI Procedes de diagnostic et de prediction de declin renal
AU2022260842B2 (en) 2021-04-20 2024-03-14 Biond Biologics Ltd. Intracellular delivery compositions
AU2022262606A1 (en) 2021-04-21 2023-11-09 Indapta Therapeutics, Inc. Methods of treatment and dosing of natural killer cell compositions
CA3216106A1 (fr) 2021-04-26 2022-11-03 Alnylam Pharmaceuticals, Inc. Compositions d'arni de protease transmembranaire, de serine 6 (tmprss6) et leurs procedes d'utilisation
EP4329884A1 (fr) 2021-04-27 2024-03-06 Generation Bio Co. Vecteurs d'adn non viraux exprimant des anticorps anti-coronavirus et leurs utilisations
KR20240011714A (ko) 2021-04-27 2024-01-26 제너레이션 바이오 컴퍼니 치료용 항체를 발현하는 비바이러스성 dna 벡터 및 이의 용도
EP4330396A1 (fr) 2021-04-29 2024-03-06 Alnylam Pharmaceuticals, Inc. Transducteur de signal et activateur de compositions d'arni du facteur de transcription 6 (stat6) et procédés d'utilisation correspondants
WO2022229846A1 (fr) 2021-04-29 2022-11-03 Pfizer Inc. Traitement du cancer à l'aide d'un inhibiteur du récepteur du facteur de croissance transformant bêta de type 1
MX2023013079A (es) 2021-05-03 2023-11-16 Astellas Inst For Regenerative Medicine Metodos de generacion de celulas maduras del endotelio corneal.
WO2022235929A1 (fr) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Modèle animal ayant une recombinaison homologue du récepteur pth1 de souris
EP4334354A1 (fr) 2021-05-06 2024-03-13 Dana-Farber Cancer Institute, Inc. Anticorps anti-alk et leurs procédés d'utilisation
EP4334472A1 (fr) 2021-05-06 2024-03-13 F. Hoffmann-La Roche AG Compositions et procédés de détection d'un virus de l'hépatite delta par un dosage à double cible
KR20240005887A (ko) 2021-05-07 2024-01-12 아스텔라스 인스티튜트 포 리제너러티브 메디슨 성숙한 간세포를 발생시키는 방법
CA3218291A1 (fr) 2021-05-12 2022-11-17 Lior Moshe ZELCBUCH Bacteriophage de staphylococcus et ses utilisations
CA3218222A1 (fr) 2021-05-14 2022-11-17 Gen-Probe Incorporated Compositions et procedes de detection d'acide nucleique d'adenovirus humain
WO2022245583A1 (fr) 2021-05-18 2022-11-24 Alnylam Pharmaceuticals, Inc. Compositions d'arni de cotransporteur-2 de sodium-glucose (sglt2) et leurs procédés d'utilisation
BR112023024014A2 (pt) 2021-05-19 2024-02-06 Seqstant Gmbh Método para análise de sequência em tempo real de fragmentos de dna, oligonucleotídeo adaptador e kit para sequenciamento paralelo em tempo real e uso destes
BR112023023935A2 (pt) 2021-05-19 2024-01-30 Janssen Pharmaceutica Nv Inibidores de tirosina quinase de fgfr para o tratamento de tumores sólidos avançados
EP4341405A1 (fr) 2021-05-20 2024-03-27 Korro Bio, Inc. Procédés et compositions pour l'édition médiée par adar
CN118019982A (zh) 2021-05-25 2024-05-10 耶路撒冷希伯来大学伊萨姆研发有限公司 通过多组学平台诊断孤独症谱系障碍
EP4347796A1 (fr) 2021-05-26 2024-04-10 Fujifilm Cellular Dynamics, Inc. Procédés pour empêcher le silençage rapide de gènes dans des cellules souches pluripotentes
WO2022248531A1 (fr) 2021-05-26 2022-12-01 Evaxion Biotech A/S Vaccination ciblant des pathogènes intracellulaires
BR112023024446A2 (pt) 2021-05-26 2024-02-06 Univ Illinois Plantas c4 com aumento de eficiência fotossintética
WO2022251712A1 (fr) 2021-05-28 2022-12-01 Sana Biotechnology, Inc. Particules lipidiques contenant une glycoprotéine d'enveloppe de rétrovirus endogène de babouin (baev) tronquée et méthodes et utilisations associées
IL283563A (en) 2021-05-30 2022-12-01 Yeda Res & Dev Profiling of amps for the diagnosis, monitoring and treatment of microbiome-related diseases
EP4347877A1 (fr) 2021-06-01 2024-04-10 10X Genomics, Inc. Procédés et compositions pour la détection d'analytes et la résolution de sondes
TW202317762A (zh) 2021-06-02 2023-05-01 美商艾拉倫製藥股份有限公司 含有類PATATIN磷脂酶結構域3(PNPLA3)的iRNA組成物及其使用方法
US20220387581A1 (en) 2021-06-03 2022-12-08 Mazen Animal Health Inc. Oral administration of coronavirus spike protein for altering cytokine levels and providing passive immunity to newborn pigs
KR20240017911A (ko) 2021-06-04 2024-02-08 알닐람 파마슈티칼스 인코포레이티드 인간 염색체 9 개방 해독 프레임 72(C9orf72) iRNA 제제 조성물 및 이의 사용 방법
WO2022259242A1 (fr) 2021-06-06 2022-12-15 Yeda Research And Development Co. Ltd. Traitement combiné du cancer
CN117642516A (zh) 2021-06-07 2024-03-01 株式会社日立高新技术 Dna检测方法和dna检测系统
WO2022261183A2 (fr) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions et procédés de traitement et/ou d'identification d'un agent pour le traitement de cancers intestinaux
WO2022260939A2 (fr) 2021-06-08 2022-12-15 Alnylam Pharmaceuticals, Inc. Compositions et méthodes de traitement ou de prévention de la maladie de stargardt et/ou de troubles associés à la protéine 4 de liaison du rétinol (rbp4)
CA3230677A1 (fr) 2021-06-13 2022-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procede de reprogrammation de cellules humaines
WO2022265965A1 (fr) 2021-06-14 2022-12-22 10X Genomics, Inc. Variants de la transcriptase inverse pour une performance améliorée
AU2022291742A1 (en) 2021-06-14 2023-12-21 Generation Bio Co. Cationic lipids and compositions thereof
US20220409665A1 (en) 2021-06-15 2022-12-29 Allogene Therapeutics, Inc. Selective targeting of host cd70+ alloreactive cells to prolong allogeneic car t cell persistence
WO2022264033A1 (fr) 2021-06-15 2022-12-22 Takeda Pharmaceutical Company Limited Procédé de production de cellules tueuses naturelles à partir de cellules souches pluripotentes
NL2028466B1 (en) 2021-06-16 2022-12-21 Sakata Holland B V Methods of sorting matthiola seeds
EP4355502A1 (fr) 2021-06-16 2024-04-24 Seedx Technologies Inc. Procédés de tri de graines de matthiola
WO2022269023A1 (fr) 2021-06-25 2022-12-29 F. Hoffmann-La Roche Ag Procédés pour réaliser une pcr multiplexée en température avec une sensibilité accrue
EP4363574A1 (fr) 2021-06-29 2024-05-08 Korro Bio, Inc. Procédés et compositions pour édition médiée par adar
US20230194709A9 (en) 2021-06-29 2023-06-22 Seagate Technology Llc Range information detection using coherent pulse sets with selected waveform characteristics
WO2023275590A1 (fr) 2021-06-29 2023-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Détection de phosphoinositides dans des cellules sanguines en tant que biomarqueur pour des pathologies associées à l'alpha-synucléine et procédé de traitement de la maladie de parkinson et des neurodégénérescences associées
CA3225469A1 (fr) 2021-06-30 2023-01-05 Alnylam Pharmaceuticals, Inc. Procedes et compositions pour le traitement d'un trouble associe a l'angiotensinogene (agt)
AU2022305653A1 (en) 2021-06-30 2024-01-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for enrichment of nucleic acids using light-mediated cross-linking
WO2023278811A1 (fr) 2021-07-01 2023-01-05 Indapta Therapeutics, Inc. Cellules tueuses naturelles (nk) modifiées et méthodes associées
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
KR20240031315A (ko) 2021-07-02 2024-03-07 트로픽 바이오사이언시즈 유케이 리미티드 바나나 과실의 갈변 지연 또는 예방
EP4366762A1 (fr) 2021-07-05 2024-05-15 Evaxion Biotech A/S Vaccins ciblant neisseria gonorrhoeae
WO2023281463A1 (fr) 2021-07-09 2023-01-12 Janssen Biotech, Inc. Procédés de fabrication pour produire des compositions d'anticorps anti-tnf
AU2022306144A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
EP4367138A1 (fr) 2021-07-09 2024-05-15 Janssen Biotech, Inc. Procédés de fabrication permettant de produire des compositions d'anticorps anti-il12/il23
US20230012607A1 (en) 2021-07-09 2023-01-19 10X Genomics, Inc. Methods for detecting analytes using sparse labelling
WO2023283452A2 (fr) 2021-07-09 2023-01-12 Cepheid Récipient de réaction de multiplexage à haut niveau, dispositif d'application de réactif et procédés associés
IL310226A (en) 2021-07-18 2024-03-01 Gamida Cell Ltd NK cell populations for treatment
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
EP4373937A1 (fr) 2021-07-21 2024-05-29 Alnylam Pharmaceuticals, Inc. Compositions d'arni de gène cible associé à un trouble métabolique et leurs méthodes d'utilisation
CA3227000A1 (fr) 2021-07-21 2023-01-26 Seegene, Inc. Systeme d'analyse assemble, procede et support d'enregistrement lisible par ordinateur
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
EP4373965A1 (fr) 2021-07-21 2024-05-29 DNAe Diagnostics Limited Procédé et système comprenant une cartouche pour le séquençage de polynucléotides cibles
WO2023002492A1 (fr) 2021-07-22 2023-01-26 Yeda Research And Development Co. Ltd. Optimisation de codon d'acides nucléiques
EP4373933A1 (fr) 2021-07-23 2024-05-29 Alnylam Pharmaceuticals, Inc. Compositions d'arni de bêta-caténine (ctnnb1) et leurs méthodes d'utilisation
CA3226812A1 (fr) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions et procedes de detection d'agents pathogenes gastro-intestinaux
WO2023007374A1 (fr) 2021-07-27 2023-02-02 Pfizer Inc. Méthode de traitement de la douleur liée au cancer à l'aide de tanézumab
WO2023009687A1 (fr) 2021-07-29 2023-02-02 Alnylam Pharmaceuticals, Inc. Compositions d'arni de 3-hydroxy-3-méthylglutaryle-coa réductase (hmgcr) et leurs procédés d'utilisation
WO2023007468A1 (fr) 2021-07-30 2023-02-02 Helaina, Inc. Procédés et compositions pour la synthèse et la sécrétion de protéines
EP4380973A2 (fr) 2021-08-02 2024-06-12 Yeda Research and Development Co. Ltd. Anticorps pour le traitement du cancer
CA3227875A1 (fr) 2021-08-02 2023-02-09 Pfizer Inc. Vecteurs d'expression ameliores et leurs utilisations
WO2023014729A1 (fr) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits et procédés de détection de charges de séquences d'acides nucléiques
EP4130028A1 (fr) 2021-08-03 2023-02-08 Rhazes Therapeutics Ltd Complexe tcr modifié et leurs procédés d'utilisation
CA3226947A1 (fr) 2021-08-03 2023-02-09 Muhammad YASSIN Complexe tcr modifie et ses procedes d'utilisation
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
AU2022323090A1 (en) 2021-08-03 2024-02-01 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof
GB202111193D0 (en) 2021-08-03 2021-09-15 Phoremost Ltd Pharmaceutical compounds
AU2022324003A1 (en) 2021-08-04 2024-02-08 Alnylam Pharmaceuticals, Inc. iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
EP4380352A1 (fr) 2021-08-06 2024-06-12 KWS Vegetables B.V. Résistance durable au mildiou chez l'épinard
IL310716A (en) 2021-08-10 2024-04-01 Gamida Cell Ltd Transgenic NK cells, their production and use
TW202334413A (zh) 2021-08-13 2023-09-01 美商艾拉倫製藥股份有限公司 第十二因子(F12)iRNA組成物及其使用方法
EP4134450A1 (fr) 2021-08-13 2023-02-15 Genincode Uk Limited Prédiction de la thrombo-embolie veineuse associée au cancer
WO2023021330A1 (fr) 2021-08-16 2023-02-23 University Of Oslo Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
CN117858958A (zh) 2021-08-16 2024-04-09 10X基因组学有限公司 包含分割条形码区的探针和使用方法
EP4388315A1 (fr) 2021-08-18 2024-06-26 Life Technologies Corporation Biomarqueurs de répertoire immunitaire pour la prédiction d'une réponse au traitement dans une maladie auto-immune
EP4196605A1 (fr) 2021-09-01 2023-06-21 10X Genomics, Inc. Procédés, compositions et kits pour bloquer une sonde de capture sur un réseau spatial
CA3230990A1 (fr) 2021-09-06 2023-03-09 Anna FRIDMAN-DROR Agents de blocage du decollement de cd28
GB202112866D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to fusarium wilt in a banana
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
IL286430A (en) 2021-09-14 2023-04-01 Yeda Res & Dev Multispecific antibodies for use in the treatment of diseases
US11395470B1 (en) 2021-09-14 2022-07-26 Equi-Nom Ltd. Sesame with high oil content and/or high yield
WO2023044370A2 (fr) 2021-09-17 2023-03-23 Alnylam Pharmaceuticals, Inc. Compositions d'arni et procédés de silençage de composant du complément 3 (c3)
AU2022345881A1 (en) 2021-09-20 2024-03-21 Alnylam Pharmaceuticals, Inc. Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
US20230193406A1 (en) 2021-09-22 2023-06-22 Herbalife International Of America, Inc. Methods and compositions for processing botanical materials
US20230101083A1 (en) 2021-09-30 2023-03-30 Microsoft Technology Licensing, Llc Anti-counterfeit tags using base ratios of polynucleotides
US20230101409A1 (en) 2021-09-30 2023-03-30 Microsoft Technology Licensing, Llc Anti-counterfeit tags using high-complexity polynucleotides
WO2023054848A1 (fr) 2021-09-30 2023-04-06 주식회사 씨젠 Procédé de traitement et d'analyse d'échantillon dans un système de diagnostic moléculaire
CN118076752A (zh) 2021-10-01 2024-05-24 凯杰有限公司 检查核酸扩增产物的方法
CA3234642A1 (fr) 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases et leurs utilisations
WO2023060088A1 (fr) 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Compositions de transposons et leurs procédés d'utilisation
US20230121442A1 (en) 2021-10-06 2023-04-20 Johnson & Johnson Consumer Inc. Method of Quantifying Product Impact on Human Microbiome
CA3235311A1 (fr) 2021-10-12 2023-04-20 Taris Biomedical Llc Formulations d'erdafitinib et systemes d'administration intravesicale
IL311864A (en) 2021-10-15 2024-06-01 Alnylam Pharmaceuticals Inc IRNA compositions for extrahepatic administration and methods of using them
IL312140A (en) 2021-10-18 2024-06-01 Belgian Volition Srl Using nanoporous tiling to determine the source of DNA in the bloodstream
WO2023069604A1 (fr) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits et procédés pour la quantification de séquences d'acides nucléiques à l'aide d'une norme quantitative interne
WO2023068823A1 (fr) 2021-10-21 2023-04-27 주식회사 씨젠 Dispositif et procédé pour lire un résultat positif/négatif par rapport à une substance d'essai cible dans un échantillon
CA3235262A1 (fr) 2021-10-22 2023-04-27 Amgen Inc. Constructions d'arni pour inhiber l'expression de gpam et leurs methodes d'utilisation
NL2030206B1 (en) 2021-10-25 2023-05-16 Sestina Bio Llc Heterologous expression of enzymes for increased b-farnesene production
TW202334418A (zh) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 杭丁頓(HTT)iRNA劑組成物及其使用方法
IL312399A (en) 2021-10-29 2024-06-01 Alnylam Pharmaceuticals Inc Complement factor B (CFB) iRNA compositions and methods of using them
WO2023075394A1 (fr) 2021-10-29 2023-05-04 주식회사 씨젠 Outil d'écouvillon de prélèvement d'échantillon et méthode de détection d'un agent pathogène respiratoire
IL312401A (en) 2021-10-29 2024-06-01 Janssen Biotech Inc Methods for treating Crohn's disease with a specific anti-IL23 antibody
WO2023079430A1 (fr) 2021-11-02 2023-05-11 Pfizer Inc. Méthodes de traitement de myopathies mitochondriales à l'aide d'anticorps anti-gdf15
WO2023081221A1 (fr) 2021-11-02 2023-05-11 Life Technologies Corporation Compositions et procédés pour réduire la contamination de mélange maître
CA3237102A1 (fr) 2021-11-03 2023-05-11 Biond Biologics Ltd. Compositions pour administration intracellulaire
CN118202069A (zh) 2021-11-05 2024-06-14 豪夫迈·罗氏有限公司 用于检测疟疾的组合物和方法
WO2023084488A1 (fr) 2021-11-15 2023-05-19 Janssen Biotech, Inc. Méthodes de traitement de la maladie de crohn au moyen d'un anticorps spécifique anti-il23
WO2023089186A1 (fr) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions et procédés pour la détection des gènes vana et/ou vanb associés à la multirésistance aux médicaments
CA3239216A1 (fr) 2021-11-23 2023-06-01 Janssen Biotech, Inc. Methode de traitement de la rectocolite hemorragique avec un anticorps specifique anti-il23
WO2023097119A2 (fr) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Méthodes et compositions pour moduler riok2
GB202117405D0 (en) 2021-12-02 2022-01-19 Univ London Queen Mary Peptide
GB2613386A (en) 2021-12-02 2023-06-07 Apis Assay Tech Limited Diagnostic test
CA3240113A1 (fr) 2021-12-08 2023-06-15 Yeda Research And Development Co. Ltd. Cellules progenitrices pulmonaires multipotentes pour la regeneration pulmonaire
WO2023104812A1 (fr) 2021-12-09 2023-06-15 F. Hoffmann-La Roche Ag Détection basée sur la masse d'amplicons de pcr
EP4194568A1 (fr) 2021-12-10 2023-06-14 Genincode Uk Limited Thromboembolie veineuse associée à la covid-19
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
CA3241030A1 (fr) 2021-12-15 2023-06-22 Daryl C Drummond Inhibiteurs d'exocytose des neutrophiles
TW202342757A (zh) 2021-12-17 2023-11-01 美商薩那生物科技公司 經修飾副黏液病毒科附著醣蛋白
WO2023114543A2 (fr) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Plateforme pour découverte d'anticorps
WO2023114544A1 (fr) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Anticorps et leurs utilisations
TW202342498A (zh) 2021-12-17 2023-11-01 美商薩那生物科技公司 經修飾副黏液病毒科融合醣蛋白
WO2023122762A1 (fr) 2021-12-22 2023-06-29 Camp4 Therapeutics Corporation Modulation de la transcription génique à l'aide d'oligonucléotides antisens ciblant des arn régulateurs
WO2023122758A1 (fr) 2021-12-22 2023-06-29 Cornell University Signature de cancer du sein épigénétique pronostique/prédictive
WO2023118399A1 (fr) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Détection améliorée de produits d'amplification lamp
WO2023119301A1 (fr) 2021-12-26 2023-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédés de criblage et de traitement du syndrome x fragile
WO2023129898A2 (fr) 2021-12-27 2023-07-06 10X Genomics, Inc. Procédés et compositions pour l'amplification par cercle roulant
WO2023141588A1 (fr) 2022-01-21 2023-07-27 10X Genomics, Inc. Signaux de lecture multiples pour analyser un échantillon
WO2023141576A1 (fr) 2022-01-21 2023-07-27 Poseida Therapeutics, Inc. Compositions et procédés d'administration d'acides nucléiques
WO2023141314A2 (fr) 2022-01-24 2023-07-27 Alnylam Pharmaceuticals, Inc. Compositions d'agent d'arni d'enzyme de voie de biosynthèse de sulfate d'héparine et leurs méthodes d'utilisation
WO2023144798A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Lipides cationiques ionisables pour nanoparticules lipidiques
WO2023144792A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Conjugués poly(alkyloxazoline)-lipide et particules lipidiques les contenant
WO2023148732A1 (fr) 2022-02-01 2023-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédé de sélection d'une plante génétiquement modifiée améliorée
WO2023148598A1 (fr) 2022-02-02 2023-08-10 Pfizer Inc. Prototrophie cystéinique
WO2023154678A1 (fr) 2022-02-08 2023-08-17 Amgen Inc. Acides nucléiques à optimisation de codons codant pour ocrélizumab
WO2023152568A2 (fr) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions et méthodes de caractérisation du cancer du poumon
WO2023157003A1 (fr) 2022-02-16 2023-08-24 Yeda Research And Development Co. Ltd. Procédés de raccourcissement de la durée de phase de latence dans des micro-organismes
WO2023158732A1 (fr) 2022-02-16 2023-08-24 Dana-Farber Cancer Institute, Inc. Procédés de diminution de l'alpha-synucléine pathologique à l'aide d'agents qui modulent fndc5 ou des fragments biologiquement actifs de celui-ci
WO2023159216A1 (fr) 2022-02-18 2023-08-24 Taris Biomedical Llc Formulations d'erdafitinib et systèmes osmotiques pour administration intravésicale
WO2023164573A1 (fr) 2022-02-23 2023-08-31 Poseida Therapeutics, Inc. Cellules modifiées et leurs procédés d'utilisation
US20240117030A1 (en) 2022-03-03 2024-04-11 Pfizer Inc. Multispecific antibodies and uses thereof
WO2023172694A1 (fr) 2022-03-09 2023-09-14 Dana-Farber Cancer Institute, Inc. Lymphocytes b génétiquement modifiés et procédés d'utilisation associés
WO2023177655A1 (fr) 2022-03-14 2023-09-21 Generation Bio Co. Compositions vaccinales prime-boost hétérologues et méthodes d'utilisation
US20230295661A1 (en) 2022-03-16 2023-09-21 University Of Houston System Persistent hsv gene delivery system
WO2023192895A1 (fr) 2022-03-29 2023-10-05 Allogene Therapeutics Inc. Récepteurs de commutateurs chimériques pour la conversion de signaux immunoréactifs en signaux de costimulation
GB202204595D0 (en) 2022-03-30 2022-05-11 Univ Newcastle Methods dor determining mitochondrial DNA damage
WO2023192616A1 (fr) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions et procédés de masquage ciblé d'autofluorescence
WO2023187760A1 (fr) 2022-04-01 2023-10-05 Genevant Sciences Gmbh Compositions ciblées sur le mannose
WO2023196526A1 (fr) 2022-04-06 2023-10-12 10X Genomics, Inc. Procédés d'analyse multiplex de cellules
WO2023196476A1 (fr) 2022-04-06 2023-10-12 University Of Massachusetts Compositions et procédés de complexes arn guide/marqueur de séquençage pour éditeur primaire
WO2023196884A1 (fr) 2022-04-06 2023-10-12 Juno Therapeutics, Inc. Dosage pour la détection du papillomavirus humain (vph) de type 16 (hpv-16)
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023195009A1 (fr) 2022-04-07 2023-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Bactéries génétiquement modifiées et leur utilisation
WO2023196572A1 (fr) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Cytidine désaminases modifiées et méthodes d'utilisation
WO2023201230A1 (fr) 2022-04-11 2023-10-19 The Regents Of The University Of California Procédés de criblage de gain de plante de mutations de fonction et compositions associées
TW202404993A (zh) 2022-04-11 2024-02-01 美商特納亞治療股份有限公司 具經工程化蛋白殼之腺相關病毒
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
WO2023209708A1 (fr) 2022-04-25 2023-11-02 Yeda Research And Development Co. Ltd. Compositions pour modifier la signalisation de messager secondaire de l'adp-ribose cyclique
WO2023209716A1 (fr) 2022-04-25 2023-11-02 Biond Biologics Ltd. Anticorps anti-ilt3 et leur utilisation
WO2023209070A1 (fr) 2022-04-29 2023-11-02 Novozymes A/S Production d'esters alkyliques d'acides gras
WO2023214405A1 (fr) 2022-05-01 2023-11-09 Yeda Research And Development Co. Ltd. Réexpression de hnf4a pour atténuer la cachexie associée au cancer
WO2023215860A1 (fr) 2022-05-05 2023-11-09 University Of Rochester Bactéries modifiées et procédés d'utilisation pour des microlentilles en bioverre
WO2023214346A1 (fr) 2022-05-06 2023-11-09 Novartis Ag Nouveaux polypeptides de fusion vp2 d'aav recombinants
WO2023218450A1 (fr) 2022-05-09 2023-11-16 Yeda Research And Development Co. Ltd. Champignon commensal et ses utilisations
US20240059799A1 (en) 2022-05-11 2024-02-22 Pfizer Inc. Anti-tl1a antibodies and methods of use thereof
WO2023225515A1 (fr) 2022-05-17 2023-11-23 Life Technologies Corporation Compositions et procédés pour dosages oncologiques
WO2023223265A1 (fr) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Méthode d'évaluation et de traitement de l'arthrite psoriasique avec un anticorps il23
WO2023223092A1 (fr) 2022-05-18 2023-11-23 Institut Pasteur Identification d'un circovirus humain
EP4282980A1 (fr) 2022-05-23 2023-11-29 Mobidiag Oy Procédés d'amplification d'un acide nucléique
WO2023230531A1 (fr) 2022-05-24 2023-11-30 Lunglife Ai, Inc. Procédés de détection de cellules génétiquement anormales circulantes
GB202208171D0 (en) 2022-06-01 2022-07-13 Institute Of Cancer Res Method
WO2023233413A1 (fr) 2022-06-01 2023-12-07 Yeda Research And Development Co. Ltd. Inhibiteurs de liaison eif4g1-eif1 et leur utilisation
US20230392207A1 (en) 2022-06-03 2023-12-07 Illumina, Inc. Circulating rna biomarkers for preeclampsia
WO2023238131A1 (fr) 2022-06-07 2023-12-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Méthodes de traitement de maladies génétiques liées à l'x
WO2023240201A1 (fr) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Marqueurs sensibles à la frataxine pour surveiller la progression et le traitement du syndrome de leigh
WO2023240218A1 (fr) 2022-06-09 2023-12-14 Allogene Therapeutics Inc. Procédés de détection d'anomalies génomiques dans des cellules
WO2023240277A2 (fr) 2022-06-10 2023-12-14 Camp4 Therapeutics Corporation Méthodes de modulation de l'expression de progranuline à l'aide d'oligonucléotides antisens ciblant des arn régulateurs
US20240010742A1 (en) 2022-06-10 2024-01-11 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
WO2023248220A1 (fr) 2022-06-20 2023-12-28 Yeda Research And Development Co. Ltd. Particules comprenant de l'arn double brin et leur utilisation en agriculture
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
WO2024002924A2 (fr) 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Colorants fluorescents présentant d'importants décalages de stokes
US20240003871A1 (en) 2022-06-29 2024-01-04 FUJIFILM Cellular Dynamics, Inc. Ipsc-derived astrocytes and methods of use thereof
WO2024006924A1 (fr) 2022-06-29 2024-01-04 Life Technologies Corporation Systèmes et procédés de détection d'analyte à partir de dosages multiplexés
WO2024006477A1 (fr) 2022-06-29 2024-01-04 Life Technologies Corporation Composés de colorants multiplex
WO2024003260A1 (fr) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Compositions et procédés de détection de sérovars de chlamydia trachomatis provoquant un lymphogranulome vénérien (lgv)
WO2024007020A1 (fr) 2022-06-30 2024-01-04 Indapta Therapeutics, Inc. Combinaison de cellules tueuses naturelles (nk) modifiées et d'une thérapie par anticorps et méthodes associées
WO2024003332A1 (fr) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Régulation de la taille des inserts de la banque de séquençage par tagmentation à l'aide de protéines de type histone d'origine archéenne
WO2024013742A1 (fr) 2022-07-11 2024-01-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Amélioration du traitement de la thérapie par transfert adoptif de cellules (act)
WO2024015766A1 (fr) 2022-07-12 2024-01-18 Topogene Inc. Réplication évolutive de puces adn avec une résolution inférieure au micron
WO2024020360A1 (fr) 2022-07-18 2024-01-25 Pairwise Plants Services, Inc. Plantes vertes de moutarde nommées 'pwrg-1', 'pwrg-2,' et 'pwsgc'
US20240042030A1 (en) 2022-07-29 2024-02-08 Allogene Therapeutics, Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition
WO2024030345A1 (fr) 2022-08-05 2024-02-08 Life Technologies Corporation Compositions, kits et procédés de détection de souches variantes du virus de la peste porcine africaine
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
WO2024040041A1 (fr) 2022-08-15 2024-02-22 Dicerna Pharmaceuticals, Inc. Régulation de l'activité de molécules d'arni
WO2024040060A1 (fr) 2022-08-16 2024-02-22 10X Genomics, Inc. Ap50 polymérases et leurs utilisations
WO2024038457A1 (fr) 2022-08-18 2024-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procédé pour déterminer le tissu ou la cellule d'origine de l'adn
WO2024039776A2 (fr) 2022-08-18 2024-02-22 Alnylam Pharmaceuticals, Inc. Compositions d'arnsi universelles ne ciblant pas et procédés d'utilisation associés
WO2024040222A1 (fr) 2022-08-19 2024-02-22 Generation Bio Co. Adn à extrémités fermées clivable (adnce) et ses procédés d'utilisation
WO2024042042A1 (fr) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions et méthodes de détection du virus de l'orthopoxvirose simienne
WO2024050308A1 (fr) 2022-08-29 2024-03-07 Microgenics Corporation Témoins d'acides nucléiques totaux acellulaires
WO2024046992A1 (fr) 2022-09-02 2024-03-07 F. Hoffmann-La Roche Ag Amélioration de la performance de l'enrichissement des cibles de nouvelle génération
WO2024054924A1 (fr) 2022-09-08 2024-03-14 Gen-Probe Incorporated Procédé de détection d'analytes d'acides nucléiques à l'aide d'amorces à double spécificité
WO2024054925A1 (fr) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits et méthodes de détection de séquences de variants viraux
WO2024057190A2 (fr) 2022-09-12 2024-03-21 Genevant Sciences Gmbh Compositions ciblées
WO2024064838A1 (fr) 2022-09-21 2024-03-28 Sana Biotechnology, Inc. Particules lipidiques comprenant des glycoprotéines fixant des paramyxovirus variants et leurs utilisations
WO2024073047A1 (fr) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine désaminases et procédés d'utilisation dans la cartographie de nucléotides cytosine modifiés
WO2024069581A1 (fr) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Complexes hélicase-cytidine désaminase et procédés d'utilisation
WO2024073043A1 (fr) 2022-09-30 2024-04-04 Illumina, Inc. Procédés d'utilisation de protéines de liaison cpg dans la cartographie de nucléotides cytosine modifiés
WO2024077152A1 (fr) 2022-10-06 2024-04-11 Illumina, Inc. Sondes servant à appauvrir un petit arn non codant abondant
WO2024077202A2 (fr) 2022-10-06 2024-04-11 Illumina, Inc. Sondes pour améliorer la surveillance d'échantillons environnementaux
WO2024077162A2 (fr) 2022-10-06 2024-04-11 Illumina, Inc. Sondes pour améliorer la surveillance d'échantillons de coronavirus
WO2024079078A1 (fr) 2022-10-10 2024-04-18 Uniqure France Méthodes et compositions pour le traitement de l'épilepsie
WO2024081776A1 (fr) 2022-10-13 2024-04-18 Gen-Probe Incorporated Contrôle de la cellularité pour dosages d'acides nucléiques
WO2024081820A1 (fr) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Particules virales ciblant des cellules souches hématopoïétiques
WO2024092158A1 (fr) 2022-10-27 2024-05-02 Microgenics Corporation Stabilisation d'acides nucléiques dans des liquides corporels
KR20240060504A (ko) 2022-10-28 2024-05-08 주식회사 씨젠 타깃 분석물 검출 카트리지
WO2024102283A1 (fr) 2022-11-09 2024-05-16 Illumina, Inc. Procédés de séquençage de polynucléotides longs
WO2024099985A1 (fr) 2022-11-10 2024-05-16 Bayer Aktiengesellschaft Application ciblée de produits de protection de cultures basée sur des profils génétiques
WO2024107993A1 (fr) 2022-11-16 2024-05-23 Dicerna Pharmaceuticals, Inc. Oligonucléotides de ciblage de stat3 et leurs utilisations
WO2024110898A1 (fr) 2022-11-22 2024-05-30 Janssen Biotech, Inc. Méthode de traitement de la rectocolite hémorragique avec un anticorps spécifique anti-il23
WO2024118903A1 (fr) 2022-11-30 2024-06-06 Illumina, Inc. Correction chimio-enzymatique de transformations d'uracile faux positives
WO2024119074A1 (fr) 2022-12-01 2024-06-06 Generation Bio Co. Compositions de nanoparticules lipidiques furtives pour le ciblage cellulaire
WO2024119145A1 (fr) 2022-12-01 2024-06-06 Camp4 Therapeutics Corporation Modulation de la transcription du gène syngap1 à l'aide d'oligonucléotides antisens ciblant les arn régulateurs
WO2024119157A1 (fr) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Particules lipidiques avec cofusogènes et leurs procédés de production et d'utilisation
WO2024123672A1 (fr) 2022-12-05 2024-06-13 Life Technologies Corporation Suppression de signal hors cible dans des réactions d'amplification d'acide nucléique
EP4389911A1 (fr) 2022-12-21 2024-06-26 Mobidiag Oy Procédés et systèmes pour isoler un analyte
EP4389887A1 (fr) 2022-12-21 2024-06-26 Mobidiag Oy Isolation et lyse de cellules
EP4389913A1 (fr) 2022-12-23 2024-06-26 Universität Heidelberg Procédé de détection d'un acide nucléique cible dans un échantillon sans anticorps analogue à la pcr- elisa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4351901A (en) * 1980-03-24 1982-09-28 Cetus Corporation Method for single nucleotide alteration
EP0138242A1 (fr) * 1983-09-07 1985-04-24 Duphar International Research B.V Procédé pour la préparation d'ADN complémentaire du génome des coronavirus
JPS61501186A (ja) * 1983-10-11 1986-06-19 インターナシヨナル ジネテイツク エンジニアリング インコーポレイテツド タウマチン(Thaumatin)遺伝子の作製と発現
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

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DE3650679T3 (de) 2004-10-21
EP0505012B2 (fr) 2004-01-21
HK1010791A1 (en) 1999-06-25
ES8706822A1 (es) 1987-06-16
IE930229L (en) 1986-09-28
KR900008742B1 (ko) 1990-11-29
KR910008641B1 (ko) 1991-10-19
DE3650679T2 (de) 1999-01-14
DE3650679D1 (de) 1998-06-10
ATE165869T1 (de) 1998-05-15
DE505012T1 (de) 1993-11-04
EP0201184B2 (fr) 2004-08-04
IE62098B1 (en) 1994-12-14
AU5532286A (en) 1986-10-02
US4683202A (en) 1987-07-28
IE930228L (en) 1986-09-28
SG111193G (en) 1994-02-25
EP0502589A2 (fr) 1992-09-09
AU586233B2 (en) 1989-07-06
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KR860007380A (ko) 1986-10-10
EP0509612A3 (fr) 1994-01-19
EP0505012A3 (fr) 1994-01-19
ES553464A0 (es) 1987-06-16
US4683202B1 (fr) 1990-11-27
DK144886A (da) 1986-09-29
EP0201184B1 (fr) 1992-12-16
EP0502588A3 (fr) 1994-01-19
EP0502589B1 (fr) 2001-09-26
EP0505012B1 (fr) 1998-05-06
DE3687287D1 (de) 1993-01-28
DK144886D0 (da) 1986-03-26
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IE860842L (en) 1986-09-28
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CA1237685A (fr) 1988-06-07
HK84094A (en) 1994-08-26
EP0505012A2 (fr) 1992-09-23
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JP2622327B2 (ja) 1997-06-18
DE201184T1 (de) 1992-04-09
IL78281A0 (en) 1986-07-31
DK171160B1 (da) 1996-07-08
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EP0502588A2 (fr) 1992-09-09
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