BRPI0413695A - derivados de naftiridina substituìda como inibidores do fator inibidor da migração de macrófagos e seu uso no tratamento de doenças humanas - Google Patents

derivados de naftiridina substituìda como inibidores do fator inibidor da migração de macrófagos e seu uso no tratamento de doenças humanas

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Publication number
BRPI0413695A
BRPI0413695A BRPI0413695-0A BRPI0413695A BRPI0413695A BR PI0413695 A BRPI0413695 A BR PI0413695A BR PI0413695 A BRPI0413695 A BR PI0413695A BR PI0413695 A BRPI0413695 A BR PI0413695A
Authority
BR
Brazil
Prior art keywords
treatment
inhibitors
macrophage migration
mif
human disease
Prior art date
Application number
BRPI0413695-0A
Other languages
English (en)
Inventor
Jagadish C Sircar
Sunil K C Kumar
Wenbin Ying
Timothy James Davis
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0413695(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of BRPI0413695A publication Critical patent/BRPI0413695A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

"DERIVADOS DE NAFTIRIDINA SUBSTITUìDA COMO INIBIDORES DO FATOR INIBIDOR DA MIGRAçãO DE MACRóFAGOS E SEU USO NO TRATAMENTO DE DOENçAS HUMANAS". São fornecidos inibidores de MIF tendo uma cadeia principal de naftiridina, que têm utilidade no tratamento de uma variedade de distúrbios, incluindo o tratamento de condições patológicas associadas à atividade do MIF. Os inibidores de MIF têm as seguintes estruturas: (Ia) , (Ib) , (Ic), (Id) , incluindo estereoisómeros, pró-drogas e sais farmaceuticamente aceitáveis destes, em que n, R, R~ 1~, R~ 2~, X, Y e Z são como definidos aqui. Composições contendo um inibidor de MIF em combinação com um veículo farmaceuticamente aceitável, bem como métodos para uso das mesmas são também fornecidos.
BRPI0413695-0A 2003-08-22 2004-08-09 derivados de naftiridina substituìda como inibidores do fator inibidor da migração de macrófagos e seu uso no tratamento de doenças humanas BRPI0413695A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49744303P 2003-08-22 2003-08-22
PCT/US2004/025683 WO2005021546A1 (en) 2003-08-22 2004-08-09 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases

Publications (1)

Publication Number Publication Date
BRPI0413695A true BRPI0413695A (pt) 2006-10-24

Family

ID=34272569

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413695-0A BRPI0413695A (pt) 2003-08-22 2004-08-09 derivados de naftiridina substituìda como inibidores do fator inibidor da migração de macrófagos e seu uso no tratamento de doenças humanas

Country Status (13)

Country Link
US (2) US20050124604A1 (pt)
EP (1) EP1656376A1 (pt)
JP (1) JP2007503388A (pt)
CN (1) CN1839133A (pt)
AR (1) AR045471A1 (pt)
AU (1) AU2004268941A1 (pt)
BR (1) BRPI0413695A (pt)
CA (1) CA2531506A1 (pt)
MX (1) MXJL06000006A (pt)
PE (1) PE20051112A1 (pt)
TW (1) TW200524928A (pt)
UY (1) UY28483A1 (pt)
WO (1) WO2005021546A1 (pt)

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CA2531506A1 (en) 2005-03-10
EP1656376A1 (en) 2006-05-17
CN1839133A (zh) 2006-09-27
US20070191388A1 (en) 2007-08-16
US7361760B2 (en) 2008-04-22
AU2004268941A1 (en) 2005-03-10
US20050124604A1 (en) 2005-06-09
JP2007503388A (ja) 2007-02-22
PE20051112A1 (es) 2006-02-03
AR045471A1 (es) 2005-10-26
UY28483A1 (es) 2005-03-31
TW200524928A (en) 2005-08-01
MXJL06000006A (es) 2006-05-04

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