AR045471A1 - Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre - Google Patents

Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre

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Publication number
AR045471A1
AR045471A1 ARP040102991A ARP040102991A AR045471A1 AR 045471 A1 AR045471 A1 AR 045471A1 AR P040102991 A ARP040102991 A AR P040102991A AR P040102991 A ARP040102991 A AR P040102991A AR 045471 A1 AR045471 A1 AR 045471A1
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Argentina
Prior art keywords
substituted
group
nr4r5
heterocycle
aryl
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ARP040102991A
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English (en)
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Jagadish Sircar
K C Sunil Kumar
Wenbin Ying
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Avanir Pharmaceuticals
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Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of AR045471A1 publication Critical patent/AR045471A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
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Abstract

Se proveen inhibidores del factor inhibidor de la migración de macrófagos (MIF) con una estructura principal de naftiridina que son de utilidad en el tratamiento de una variedad de trastornos, incluyendo el tratamiento de afecciones patológicas asociadas con la actividad del MIF. Los inhibidores del MIF tienen las estructuras de las fórmulas (1), que incluyen estereoisómeros, prodrogas y sales aceptables para uso farmacéutico de los mismos. También se proveen composiciones que contienen un inhibidor de MIF en combinación con un vehículo aceptable para uso farmacéutico, así como métodos para utilizarlos. Reivindicación 1: Un compuesto donde, R se selecciona entre el grupo que consiste en hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, heterociclo sustituido, -(CH2)mC(=O)Ar, y -(CH2)mNR4R5; R1 se selecciona entre el grupo que consiste en -CN, -NO, -NO2, -C(=O)R3, -C(=O)OH, -NHC(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -SO2NR4R5, -NR3SO2R3, -NHSO2R3, -S(O)mR3, -(CH2)mNR4R5, y -(CH2)mC(=O)Ar; R2 se selecciona entre el grupo que consiste en - CH2R3, -NR4R5, -OR3, y -R3; R3 se selecciona independientemente entre el grupo que consiste en alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, heterociclo sustituido; R4 y R5 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, y heterociclo sustituido, o R4 y R5 tomados juntos comprenden heterociclo o heterociclo sustituido; X se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Y se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Z se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Ar se selecciona entre el grupo que consiste en arilo y arilo sustituido; m es independientemente 0, 1, 2, 3 ó 4; y n es 0, 1 ó 2.
ARP040102991A 2003-08-22 2004-08-20 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre AR045471A1 (es)

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Application Number Priority Date Filing Date Title
US49744303P 2003-08-22 2003-08-22

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AR045471A1 true AR045471A1 (es) 2005-10-26

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ARP040102991A AR045471A1 (es) 2003-08-22 2004-08-20 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre

Country Status (13)

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US (2) US20050124604A1 (es)
EP (1) EP1656376A1 (es)
JP (1) JP2007503388A (es)
CN (1) CN1839133A (es)
AR (1) AR045471A1 (es)
AU (1) AU2004268941A1 (es)
BR (1) BRPI0413695A (es)
CA (1) CA2531506A1 (es)
MX (1) MXJL06000006A (es)
PE (1) PE20051112A1 (es)
TW (1) TW200524928A (es)
UY (1) UY28483A1 (es)
WO (1) WO2005021546A1 (es)

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US20070191388A1 (en) 2007-08-16
US7361760B2 (en) 2008-04-22
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US20050124604A1 (en) 2005-06-09
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PE20051112A1 (es) 2006-02-03
UY28483A1 (es) 2005-03-31
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BRPI0413695A (pt) 2006-10-24
MXJL06000006A (es) 2006-05-04

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