HUE064531T2 - Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorok - Google Patents
Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorokInfo
- Publication number
- HUE064531T2 HUE064531T2 HUE19744923A HUE19744923A HUE064531T2 HU E064531 T2 HUE064531 T2 HU E064531T2 HU E19744923 A HUE19744923 A HU E19744923A HU E19744923 A HUE19744923 A HU E19744923A HU E064531 T2 HUE064531 T2 HU E064531T2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds useful
- cell activators
- naphthyridinone compounds
- substituted naphthyridinone
- substituted
- Prior art date
Links
- 229940126530 T cell activator Drugs 0.000 title 1
- VHSIAYLBCLUAFT-UHFFFAOYSA-N n-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,8-naphthyridin-4-yl]acetamide Chemical class C=1C=C(Cl)C=CC=1C=1C=C2C(NC(=O)C)=C(C(C)=O)C(=O)N(C)C2=NC=1C1=CC=C(Cl)C=C1Cl VHSIAYLBCLUAFT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690439P | 2018-06-27 | 2018-06-27 | |
| US201962840459P | 2019-04-30 | 2019-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE064531T2 true HUE064531T2 (hu) | 2024-04-28 |
Family
ID=67439335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE19744923A HUE064531T2 (hu) | 2018-06-27 | 2019-06-26 | Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorok |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10669272B2 (hu) |
| EP (1) | EP3814348B9 (hu) |
| JP (1) | JP7432532B2 (hu) |
| KR (1) | KR20210024586A (hu) |
| CN (1) | CN112654621B (hu) |
| AU (1) | AU2019291794B2 (hu) |
| BR (1) | BR112020026681A2 (hu) |
| CA (1) | CA3104654A1 (hu) |
| CL (1) | CL2020003260A1 (hu) |
| DK (1) | DK3814348T3 (hu) |
| ES (1) | ES2960754T3 (hu) |
| FI (1) | FI3814348T3 (hu) |
| HR (1) | HRP20231253T1 (hu) |
| HU (1) | HUE064531T2 (hu) |
| IL (1) | IL279728B2 (hu) |
| LT (1) | LT3814348T (hu) |
| MX (1) | MX2020013817A (hu) |
| PE (1) | PE20210469A1 (hu) |
| PL (1) | PL3814348T3 (hu) |
| PT (1) | PT3814348T (hu) |
| RS (1) | RS64641B1 (hu) |
| SG (1) | SG11202012972YA (hu) |
| SI (1) | SI3814348T1 (hu) |
| TW (1) | TW202019924A (hu) |
| WO (1) | WO2020006018A1 (hu) |
| ZA (1) | ZA202100555B (hu) |
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| WO2021105115A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| WO2021105116A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| WO2021127554A1 (en) * | 2019-12-19 | 2021-06-24 | Bristol-Myers Squibb Company | Combinations of dgk inhibitors and checkpoint antagonists |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| CN114846015B (zh) * | 2019-12-23 | 2024-07-30 | 百时美施贵宝公司 | 用作t细胞激活剂的经取代的杂芳基化合物 |
| CN115175907B (zh) * | 2019-12-23 | 2024-08-02 | 百时美施贵宝公司 | 可用作t细胞激活剂的经取代的哌嗪衍生物 |
| CN117736207A (zh) | 2019-12-24 | 2024-03-22 | 卡尔那生物科学株式会社 | 二酰基甘油激酶调节化合物 |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| EP4139287A1 (en) | 2020-04-24 | 2023-03-01 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
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| TWI793877B (zh) * | 2020-11-26 | 2023-02-21 | 南韓商Ｌｇ化學股份有限公司 | 作為甘油二酯激酶抑制劑的雜環化合物及其用途 |
| KR20230116838A (ko) * | 2020-11-30 | 2023-08-04 | 아스테라스 세이야쿠 가부시키가이샤 | 헤테로아릴카르복시아미드 화합물 |
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| JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法およびｄｇｋ阻害剤の組合せ |
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| US11932634B2 (en) * | 2021-06-23 | 2024-03-19 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| CN117396478A (zh) | 2021-06-23 | 2024-01-12 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
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| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
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| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
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2019
- 2019-06-26 HU HUE19744923A patent/HUE064531T2/hu unknown
- 2019-06-26 US US16/452,679 patent/US10669272B2/en active Active
- 2019-06-26 JP JP2020572691A patent/JP7432532B2/ja active Active
- 2019-06-26 PT PT197449234T patent/PT3814348T/pt unknown
- 2019-06-26 DK DK19744923.4T patent/DK3814348T3/da active
- 2019-06-26 HR HRP20231253TT patent/HRP20231253T1/hr unknown
- 2019-06-26 SG SG11202012972YA patent/SG11202012972YA/en unknown
- 2019-06-26 WO PCT/US2019/039135 patent/WO2020006018A1/en active Application Filing
- 2019-06-26 MX MX2020013817A patent/MX2020013817A/es unknown
- 2019-06-26 RS RS20230895A patent/RS64641B1/sr unknown
- 2019-06-26 BR BR112020026681-7A patent/BR112020026681A2/pt unknown
- 2019-06-26 AU AU2019291794A patent/AU2019291794B2/en active Active
- 2019-06-26 CN CN201980055715.8A patent/CN112654621B/zh active Active
- 2019-06-26 LT LTEPPCT/US2019/039135T patent/LT3814348T/lt unknown
- 2019-06-26 EP EP19744923.4A patent/EP3814348B9/en active Active
- 2019-06-26 FI FIEP19744923.4T patent/FI3814348T3/fi active
- 2019-06-26 CA CA3104654A patent/CA3104654A1/en active Pending
- 2019-06-26 ES ES19744923T patent/ES2960754T3/es active Active
- 2019-06-26 PL PL19744923.4T patent/PL3814348T3/pl unknown
- 2019-06-26 KR KR1020217002231A patent/KR20210024586A/ko not_active Application Discontinuation
- 2019-06-26 PE PE2020002111A patent/PE20210469A1/es unknown
- 2019-06-26 SI SI201930609T patent/SI3814348T1/sl unknown
- 2019-06-27 TW TW108122537A patent/TW202019924A/zh unknown
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2020
- 2020-04-08 US US16/843,024 patent/US10954238B1/en active Active
- 2020-12-16 CL CL2020003260A patent/CL2020003260A1/es unknown
- 2020-12-23 IL IL279728A patent/IL279728B2/en unknown
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2021
- 2021-01-26 ZA ZA2021/00555A patent/ZA202100555B/en unknown
- 2021-02-01 US US17/164,009 patent/US11713316B2/en active Active
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