LT3814348T - Pakeistieji naftiridinono junginiai, naudotini kaip t ląstelių aktyvatoriai - Google Patents
Pakeistieji naftiridinono junginiai, naudotini kaip t ląstelių aktyvatoriaiInfo
- Publication number
- LT3814348T LT3814348T LTEPPCT/US2019/039135T LTUS2019039135T LT3814348T LT 3814348 T LT3814348 T LT 3814348T LT US2019039135 T LTUS2019039135 T LT US2019039135T LT 3814348 T LT3814348 T LT 3814348T
- Authority
- LT
- Lithuania
- Prior art keywords
- compounds useful
- cell activators
- naphthyridinone compounds
- substituted naphthyridinone
- substituted
- Prior art date
Links
- 229940126530 T cell activator Drugs 0.000 title 1
- VHSIAYLBCLUAFT-UHFFFAOYSA-N n-[3-acetyl-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-methyl-2-oxo-1,8-naphthyridin-4-yl]acetamide Chemical class C=1C=C(Cl)C=CC=1C=1C=C2C(NC(=O)C)=C(C(C)=O)C(=O)N(C)C2=NC=1C1=CC=C(Cl)C=C1Cl VHSIAYLBCLUAFT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690439P | 2018-06-27 | 2018-06-27 | |
| US201962840459P | 2019-04-30 | 2019-04-30 | |
| PCT/US2019/039135 WO2020006018A1 (en) | 2018-06-27 | 2019-06-26 | Substituted naphthyridinone compounds useful as t cell activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3814348T true LT3814348T (lt) | 2023-10-10 |
Family
ID=67439335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2019/039135T LT3814348T (lt) | 2018-06-27 | 2019-06-26 | Pakeistieji naftiridinono junginiai, naudotini kaip t ląstelių aktyvatoriai |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10669272B2 (lt) |
| EP (1) | EP3814348B9 (lt) |
| JP (1) | JP7432532B2 (lt) |
| KR (1) | KR20210024586A (lt) |
| CN (1) | CN112654621B (lt) |
| AU (1) | AU2019291794B2 (lt) |
| BR (1) | BR112020026681A2 (lt) |
| CA (1) | CA3104654A1 (lt) |
| CL (1) | CL2020003260A1 (lt) |
| DK (1) | DK3814348T3 (lt) |
| ES (1) | ES2960754T3 (lt) |
| FI (1) | FI3814348T3 (lt) |
| HR (1) | HRP20231253T1 (lt) |
| HU (1) | HUE064531T2 (lt) |
| IL (1) | IL279728B2 (lt) |
| LT (1) | LT3814348T (lt) |
| MX (1) | MX2020013817A (lt) |
| PE (1) | PE20210469A1 (lt) |
| PL (1) | PL3814348T3 (lt) |
| PT (1) | PT3814348T (lt) |
| RS (1) | RS64641B1 (lt) |
| SG (1) | SG11202012972YA (lt) |
| SI (1) | SI3814348T1 (lt) |
| TW (1) | TW202019924A (lt) |
| WO (1) | WO2020006018A1 (lt) |
| ZA (1) | ZA202100555B (lt) |
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| CN111471059B (zh) * | 2019-01-23 | 2022-12-02 | 药捷安康(南京)科技股份有限公司 | Pde9抑制剂及其用途 |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| EP4065584A1 (en) | 2019-11-28 | 2022-10-05 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| CA3163105A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| CA3162767A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| AU2020407130A1 (en) * | 2019-12-19 | 2022-06-16 | Bristol-Myers Squibb Company | Combinations of DGK inhibitors and checkpoint antagonists |
| MX2022007372A (es) * | 2019-12-23 | 2022-07-12 | Bristol Myers Squibb Co | Compuestos de heteroarilo sustituidos utiles como activadores de celulas t. |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| US20230118629A1 (en) * | 2019-12-23 | 2023-04-20 | Bristol-Myers Squibb Company | Substituted piperazine derivatives useful as t cell activators |
| EP4081305B1 (en) | 2019-12-24 | 2024-09-18 | Carna Biosciences, Inc. | Diacylglycerol kinase modulating compounds |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| US20230167103A1 (en) * | 2020-04-24 | 2023-06-01 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| WO2021258010A1 (en) * | 2020-06-19 | 2021-12-23 | Gossamer Bio Services, Inc. | Oxime compounds useful as t cell activators |
| WO2022114812A1 (ko) * | 2020-11-26 | 2022-06-02 | 주식회사 엘지화학 | 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도 |
| AU2021389180A1 (en) | 2020-11-30 | 2023-06-29 | Astellas Pharma Inc. | Heteroaryl carboxamide compound |
| EP4262986A1 (en) | 2020-12-16 | 2023-10-25 | Gossamer Bio Services, Inc. | Compounds useful as t cell activators |
| CN117693508A (zh) | 2021-03-03 | 2024-03-12 | 朱诺治疗学股份有限公司 | T细胞疗法和dgk抑制剂的组合 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| AU2022297367A1 (en) | 2021-06-23 | 2023-12-07 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359411A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240025616A (ko) | 2021-06-23 | 2024-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 다이아실글리세롤 키나제 조절 화합물 |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| WO2023150186A1 (en) * | 2022-02-01 | 2023-08-10 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
| AR128669A1 (es) | 2022-03-01 | 2024-06-05 | Insilico Medicine Ip Ltd | INHIBIDORES DE DIACILGLICEROL CINASA (DGK) a Y USOS DE LOS MISMOS |
| WO2023165509A1 (en) * | 2022-03-01 | 2023-09-07 | Insilico Medicine Ip Limited | Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof |
| WO2023165525A1 (en) * | 2022-03-01 | 2023-09-07 | Insilico Medicine Ip Limited | Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023184327A1 (en) * | 2022-03-31 | 2023-10-05 | InventisBio Co., Ltd. | Kinase inhibitors, preparation methods and uses thereof |
| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
| WO2024165470A1 (en) | 2023-02-06 | 2024-08-15 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors |
| CN116375654A (zh) * | 2023-03-22 | 2023-07-04 | 湖北三峡实验室 | 一种由双甘肽制备2,5-二酮哌嗪的方法 |
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-
2019
- 2019-06-26 KR KR1020217002231A patent/KR20210024586A/ko not_active Application Discontinuation
- 2019-06-26 RS RS20230895A patent/RS64641B1/sr unknown
- 2019-06-26 PT PT197449234T patent/PT3814348T/pt unknown
- 2019-06-26 CN CN201980055715.8A patent/CN112654621B/zh active Active
- 2019-06-26 PE PE2020002111A patent/PE20210469A1/es unknown
- 2019-06-26 WO PCT/US2019/039135 patent/WO2020006018A1/en active Application Filing
- 2019-06-26 FI FIEP19744923.4T patent/FI3814348T3/fi active
- 2019-06-26 HU HUE19744923A patent/HUE064531T2/hu unknown
- 2019-06-26 JP JP2020572691A patent/JP7432532B2/ja active Active
- 2019-06-26 HR HRP20231253TT patent/HRP20231253T1/hr unknown
- 2019-06-26 DK DK19744923.4T patent/DK3814348T3/da active
- 2019-06-26 ES ES19744923T patent/ES2960754T3/es active Active
- 2019-06-26 US US16/452,679 patent/US10669272B2/en active Active
- 2019-06-26 SG SG11202012972YA patent/SG11202012972YA/en unknown
- 2019-06-26 BR BR112020026681-7A patent/BR112020026681A2/pt unknown
- 2019-06-26 CA CA3104654A patent/CA3104654A1/en active Pending
- 2019-06-26 SI SI201930609T patent/SI3814348T1/sl unknown
- 2019-06-26 LT LTEPPCT/US2019/039135T patent/LT3814348T/lt unknown
- 2019-06-26 PL PL19744923.4T patent/PL3814348T3/pl unknown
- 2019-06-26 MX MX2020013817A patent/MX2020013817A/es unknown
- 2019-06-26 AU AU2019291794A patent/AU2019291794B2/en active Active
- 2019-06-26 EP EP19744923.4A patent/EP3814348B9/en active Active
- 2019-06-27 TW TW108122537A patent/TW202019924A/zh unknown
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2020
- 2020-04-08 US US16/843,024 patent/US10954238B1/en active Active
- 2020-12-16 CL CL2020003260A patent/CL2020003260A1/es unknown
- 2020-12-23 IL IL279728A patent/IL279728B2/en unknown
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2021
- 2021-01-26 ZA ZA2021/00555A patent/ZA202100555B/en unknown
- 2021-02-01 US US17/164,009 patent/US11713316B2/en active Active
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