SG10201906328RA - Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) - Google Patents
Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)Info
- Publication number
- SG10201906328RA SG10201906328RA SG10201906328RA SG10201906328RA SG10201906328RA SG 10201906328R A SG10201906328R A SG 10201906328RA SG 10201906328R A SG10201906328R A SG 10201906328RA SG 10201906328R A SG10201906328R A SG 10201906328RA SG 10201906328R A SG10201906328R A SG 10201906328RA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- csf1r
- antibodies
- receptor
- stimulating factor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
- G01N2333/96491—Metalloendopeptidases (3.4.24) with definite EC number
- G01N2333/96494—Matrix metalloproteases, e. g. 3.4.24.7
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
METHODS OF TREATING CONDITIONS WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating inflammatory conditions, such as rheumatoid arthritis. No Suitable Figure
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261695641P | 2012-08-31 | 2012-08-31 | |
US201361767989P | 2013-02-22 | 2013-02-22 | |
US201361778706P | 2013-03-13 | 2013-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201906328RA true SG10201906328RA (en) | 2019-08-27 |
Family
ID=50184395
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201501413YA SG11201501413YA (en) | 2012-08-31 | 2013-08-30 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
SG10201906328RA SG10201906328RA (en) | 2012-08-31 | 2013-08-30 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201501413YA SG11201501413YA (en) | 2012-08-31 | 2013-08-30 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
Country Status (14)
Country | Link |
---|---|
US (4) | US20140079699A1 (en) |
EP (2) | EP2890398A4 (en) |
JP (3) | JP2015533787A (en) |
KR (2) | KR20150047593A (en) |
CN (2) | CN104684582A (en) |
AU (2) | AU2013308635A1 (en) |
BR (1) | BR112015004426A2 (en) |
CA (1) | CA2882804A1 (en) |
HK (1) | HK1212214A1 (en) |
IL (1) | IL237351B (en) |
RU (1) | RU2718751C2 (en) |
SG (2) | SG11201501413YA (en) |
TW (2) | TWI713436B (en) |
WO (1) | WO2014036357A1 (en) |
Families Citing this family (192)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE026201T2 (en) | 2009-12-10 | 2016-05-30 | Hoffmann La Roche | Antibodies binding to human CSF1R extracellular domain 4 and their use |
ES2820517T3 (en) | 2010-05-04 | 2021-04-21 | Five Prime Therapeutics Inc | Antibodies that bind to CSF1R |
JP6242804B2 (en) | 2011-12-15 | 2017-12-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Antibody to human CSF-1R and use thereof |
US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
CN104684582A (en) | 2012-08-31 | 2015-06-03 | 戊瑞治疗有限公司 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
AR095882A1 (en) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST |
AR097584A1 (en) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1 |
UY35916A (en) | 2013-12-24 | 2015-06-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | TRICYCLIC COMPOUNDS AS BROMODOMINUM INHIBITING ANTINEOPLASTIC AGENTS |
WO2015160786A1 (en) * | 2014-04-14 | 2015-10-22 | Brigham And Women's Hospital, Inc. | Method of diagnosing, prognosing, and treating lupus nephritis |
EP3151921B1 (en) | 2014-06-06 | 2019-08-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
CA2951259A1 (en) | 2014-06-06 | 2015-12-10 | Flexus Biosciences, Inc. | Immunoregulatory agents |
EP3157957A1 (en) * | 2014-06-23 | 2017-04-26 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
JP6769948B2 (en) * | 2014-07-17 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | An isolated interleukin-34 polypeptide for use in the prevention of transplant rejection and the treatment of autoimmune diseases |
US20180113139A1 (en) * | 2014-07-28 | 2018-04-26 | Nogra Pharma Limited | Methods and compositions for diagnosing and treating inflammatory bowel disorders |
AU2015339306B2 (en) | 2014-10-29 | 2021-07-22 | Bristol-Myers Squibb Company | Combination therapy for cancer |
CN107074976B (en) * | 2014-11-04 | 2020-10-09 | 北京韩美药品有限公司 | Recombinant fusion protein capable of blocking B7/CD28 and IL6/IL6R/GP130 signal channel simultaneously |
EA201790806A1 (en) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | IMMUNOREGULATING AGENTS |
AR102537A1 (en) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | IMMUNOMODULATING AGENTS |
UY36390A (en) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
TWI758928B (en) | 2014-11-21 | 2022-03-21 | 美商必治妥美雅史谷比公司 | Antibodies against cd73 and uses thereof |
AR103232A1 (en) | 2014-12-22 | 2017-04-26 | Bristol Myers Squibb Co | TGFbR ANTAGONISTS |
TW201630937A (en) | 2014-12-22 | 2016-09-01 | 戊瑞治療有限公司 | Anti-CSF1R antibodies for treating PVNS |
US10983128B2 (en) | 2015-02-05 | 2021-04-20 | Bristol-Myers Squibb Company | CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy |
SG11201705821XA (en) | 2015-03-02 | 2017-08-30 | Rigel Pharmaceuticals Inc | TGF-ß INHIBITORS |
WO2016161286A1 (en) | 2015-04-03 | 2016-10-06 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer |
WO2016162505A1 (en) | 2015-04-08 | 2016-10-13 | F-Star Biotechnology Limited | Her2 binding agent therapies |
HUE053903T2 (en) * | 2015-04-13 | 2021-07-28 | Five Prime Therapeutics Inc | Combination therapy for cancer |
US10683290B2 (en) | 2015-05-11 | 2020-06-16 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
US9725449B2 (en) | 2015-05-12 | 2017-08-08 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
ES2770349T3 (en) | 2015-05-12 | 2020-07-01 | Bristol Myers Squibb Co | 5H-pyrido [3,2-b] indole compounds as antineoplastic agents |
LT3303396T (en) | 2015-05-29 | 2023-01-10 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
EA201890162A1 (en) | 2015-06-29 | 2018-07-31 | Бристол-Маерс Сквибб Компани | ANTIBODIES TO CD40 WITH ENHANCED AGONISTIC ACTIVITY |
CN104911168B (en) * | 2015-06-30 | 2018-03-30 | 中国人民解放军第三军医大学第一附属医院 | I-type collagen high-affinity polypeptide and its application |
EA039894B1 (en) * | 2015-07-10 | 2022-03-24 | Файв Прайм Терапьютикс, Инк. | Method of treating cancer, composition for treating cancer, use of the composition for preparation of a medicament for treating cancer characterized with presence of macrophages expressing csf1r |
US10399987B2 (en) | 2015-07-28 | 2019-09-03 | Bristol-Myer Squibb Company | TGF beta receptor antagonists |
KR20180042370A (en) | 2015-08-25 | 2018-04-25 | 브리스톨-마이어스 스큅 컴퍼니 | TGF beta receptor antagonist |
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MA44309A (en) * | 2015-11-25 | 2018-10-03 | Nogra Pharma Ltd | OLIGONUCLEOTIDES ANTISENS IL-34 AND THEIR USE METHODS |
WO2017106291A1 (en) | 2015-12-15 | 2017-06-22 | Bristol-Myers Squibb Company | Cxcr4 receptor antagonists |
US20190284293A1 (en) | 2016-03-04 | 2019-09-19 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
SG11201808821WA (en) | 2016-04-18 | 2018-11-29 | Celldex Therapeutics Inc | Agonistic antibodies that bind human cd40 and uses thereof |
WO2017192844A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
CN109415320A (en) | 2016-05-04 | 2019-03-01 | 百时美施贵宝公司 | The inhibitor and its application method of indole amine 2,3-dioxygenase |
JP2019516687A (en) | 2016-05-04 | 2019-06-20 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Indoleamine 2,3-dioxygenase inhibitors and methods of use thereof |
KR20190003686A (en) | 2016-05-04 | 2019-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | Inhibitors of indoleamine 2,3-dioxygenase and methods of use thereof |
KR20190003685A (en) | 2016-05-04 | 2019-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | Inhibitors of indoleamine 2,3-dioxygenase and methods of use thereof |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
RU2769282C2 (en) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Anti-pd-l1 and il-2 cytokines |
CN117683135A (en) | 2016-07-14 | 2024-03-12 | 百时美施贵宝公司 | Antibodies against TIM3 and uses thereof |
US20190292179A1 (en) | 2016-07-21 | 2019-09-26 | Bristol-Myers Squibb Company | TGF Beta RECEPTOR ANTAGONISTS |
WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
EP3503916A1 (en) | 2016-08-26 | 2019-07-03 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
CN109843293A (en) | 2016-08-26 | 2019-06-04 | 百时美施贵宝公司 | The inhibitor and its application method of indole amine 2,3-dioxygenase |
US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
US10961239B2 (en) | 2017-01-05 | 2021-03-30 | Bristol-Myers Squibb Company | TGF beta receptor antagonists |
FI3570844T3 (en) | 2017-01-20 | 2023-11-10 | Arcus Biosciences Inc | Azolopyrimidine for the treatment of cancer-related disorders |
JP7121029B2 (en) * | 2017-02-27 | 2022-08-17 | シャタック ラボ,インコーポレイテッド | CSF1R-based chimeric protein |
TWI788340B (en) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | Anti-icos agonist antibodies and uses thereof |
JP2020517256A (en) | 2017-04-19 | 2020-06-18 | エルスター セラピューティクス, インコーポレイテッド | Multispecific molecules and uses thereof |
MX2019012431A (en) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Indole ahr inhibitors and uses thereof. |
WO2018209049A1 (en) | 2017-05-12 | 2018-11-15 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
WO2018209298A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
CN110636846B (en) | 2017-05-17 | 2023-05-16 | 艾库斯生物科学有限公司 | Quinazoline pyrazole derivatives for the treatment of cancer-related diseases |
IL271601B1 (en) | 2017-06-30 | 2024-01-01 | Bristol Myers Squibb Co | Amorphous and crystalline forms of ido inhibitors |
CN110997691B (en) | 2017-07-28 | 2023-11-07 | 百时美施贵宝公司 | Cyclic dinucleotides as anticancer agents |
WO2019036657A1 (en) | 2017-08-17 | 2019-02-21 | Kyn Therapeutics | Ahr inhibitors and uses thereof |
ES2945140T3 (en) | 2017-08-31 | 2023-06-28 | Bristol Myers Squibb Co | Cyclic dinucleotides as anticancer agents |
WO2019046496A1 (en) | 2017-08-31 | 2019-03-07 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
CN111051328B (en) | 2017-08-31 | 2023-11-03 | 百时美施贵宝公司 | Cyclic dinucleotides as anticancer agents |
BR112020004879A2 (en) | 2017-09-13 | 2020-09-15 | Five Prime Therapeutics, Inc. | methods to treat pancreatic cancer, to treat cancer and to determine the responsiveness of a subject with cancer |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
AU2018338314A1 (en) | 2017-09-22 | 2020-04-09 | Kymera Therapeutics, Inc | Protein degraders and uses thereof |
WO2019074822A1 (en) | 2017-10-09 | 2019-04-18 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
US11203592B2 (en) | 2017-10-09 | 2021-12-21 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
US11660311B2 (en) | 2017-10-10 | 2023-05-30 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
CN111406063B (en) | 2017-10-16 | 2023-09-15 | 百时美施贵宝公司 | Cyclic dinucleotides as anticancer agents |
JP2021501801A (en) | 2017-11-01 | 2021-01-21 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Immunostimulatory agonist antibody for use in the treatment of cancer |
KR20200085303A (en) | 2017-11-06 | 2020-07-14 | 브리스톨-마이어스 스큅 컴퍼니 | Isofuranone compounds useful as HPK1 inhibitors |
US20190142722A1 (en) * | 2017-11-10 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for promoting or inducing hair growth |
JP7348899B2 (en) | 2017-12-08 | 2023-09-21 | マレンゴ・セラピューティクス,インコーポレーテッド | Multispecific molecules and their uses |
IL275649B2 (en) | 2017-12-26 | 2023-12-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
WO2019133747A1 (en) | 2017-12-27 | 2019-07-04 | Bristol-Myers Squibb Company | Anti-cd40 antibodies and uses thereof |
WO2019136112A1 (en) | 2018-01-05 | 2019-07-11 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
KR20200108870A (en) | 2018-01-12 | 2020-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | Antibodies to TIM3 and uses thereof |
US20210077832A1 (en) | 2018-01-26 | 2021-03-18 | Celldex Therapeutics, Inc. | Methods of treating cancer with dendritic cell mobilizing agents |
AU2019212969A1 (en) | 2018-01-29 | 2020-08-13 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
SG11202006701TA (en) | 2018-01-29 | 2020-08-28 | Merck Patent Gmbh | Gcn2 inhibitors and uses thereof |
US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
WO2019165315A1 (en) | 2018-02-23 | 2019-08-29 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists alone or in combination |
JP7250808B2 (en) | 2018-03-08 | 2023-04-03 | ブリストル-マイヤーズ スクイブ カンパニー | Cyclic dinucleotides as anticancer agents |
CA3092589A1 (en) | 2018-03-21 | 2019-09-26 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
CN111886256A (en) | 2018-03-23 | 2020-11-03 | 百时美施贵宝公司 | anti-MICA and/or MICB antibodies and uses thereof |
CN112154153A (en) | 2018-03-28 | 2020-12-29 | 百时美施贵宝公司 | Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use |
CA3096674A1 (en) | 2018-04-12 | 2019-10-17 | Bristol-Myers Squibb Company | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
CN112292128A (en) | 2018-04-16 | 2021-01-29 | 阿瑞斯医疗有限公司 | EP4 inhibitors and uses thereof |
WO2019213340A1 (en) | 2018-05-03 | 2019-11-07 | Bristol-Myers Squibb Company | Uracil derivatives as mer-axl inhibitors |
US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
SI3814347T1 (en) | 2018-06-27 | 2023-07-31 | Bristol-Myers Squibb Company | Naphthyridinone compounds useful as t cell activators |
SG11202012972YA (en) | 2018-06-27 | 2021-01-28 | Bristol Myers Squibb Co | Substituted naphthyridinone compounds useful as t cell activators |
EP3817748A4 (en) | 2018-07-06 | 2022-08-24 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
JP7411627B2 (en) | 2018-07-09 | 2024-01-11 | ファイヴ プライム セラピューティクス インク | Antibody that binds to ILT4 |
MX2021000213A (en) | 2018-07-11 | 2021-03-25 | Five Prime Therapeutics Inc | Antibodies binding to vista at acidic ph. |
US20210355113A1 (en) | 2018-07-23 | 2021-11-18 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
WO2020023355A1 (en) | 2018-07-23 | 2020-01-30 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
US10959986B2 (en) | 2018-08-29 | 2021-03-30 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
US11253525B2 (en) | 2018-08-29 | 2022-02-22 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
CN113286817A (en) | 2018-09-25 | 2021-08-20 | 哈普恩治疗公司 | DLL3 binding proteins and methods of use |
US20220242957A1 (en) | 2018-09-27 | 2022-08-04 | Marengo Therapeutics, Inc. | Csf1r/ccr2 multispecific antibodies |
US11130802B2 (en) | 2018-10-10 | 2021-09-28 | Tilos Therapeutics, Inc. | Anti-lap antibody variants |
TW202033555A (en) | 2018-11-16 | 2020-09-16 | 美商必治妥美雅史谷比公司 | Anti-nkg2a antibodies and uses thereof |
CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
US20220016168A1 (en) | 2018-12-11 | 2022-01-20 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
EP3670659A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Biomarkers, and uses in treatment of viral infections, inflammations, or cancer |
AU2020242284A1 (en) | 2019-03-19 | 2021-09-16 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Combination therapy for the treatment of cancer |
WO2020201753A1 (en) | 2019-04-02 | 2020-10-08 | Bicycletx Limited | Bicycle toxin conjugates and uses thereof |
EP3946360A4 (en) | 2019-04-05 | 2023-05-10 | Kymera Therapeutics, Inc. | Stat degraders and uses thereof |
WO2020231766A1 (en) | 2019-05-13 | 2020-11-19 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
US20230242478A1 (en) | 2019-05-13 | 2023-08-03 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
EP3976192A1 (en) | 2019-05-31 | 2022-04-06 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
US20220306630A1 (en) | 2019-08-06 | 2022-09-29 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
AR119821A1 (en) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | SUBSTITUTED PYRIDOPYRIMIDINOL COMPOUNDS USEFUL AS T-CELL ACTIVATORS |
BR112022004451A2 (en) | 2019-09-13 | 2022-06-21 | Nimbus Saturn Inc | hpk1 antagonists and uses thereof |
JP2022548292A (en) | 2019-09-19 | 2022-11-17 | ブリストル-マイヤーズ スクイブ カンパニー | Antibodies that bind VISTA at acidic pH |
AU2020387392A1 (en) | 2019-11-19 | 2022-07-14 | Bristol-Myers Squibb Company | Compounds useful as inhibitors of Helios protein |
MX2022006308A (en) | 2019-11-26 | 2022-06-22 | Ikena Oncology Inc | Polymorphic carbazole derivatives and uses thereof. |
CN115151306A (en) | 2019-11-26 | 2022-10-04 | 百时美施贵宝公司 | Salts/co-crystals of (R) -N- (4-chlorophenyl) -2- ((1S, 4S) -4- (6-fluoroquinolin-4-yl) cyclohexyl) propanamide |
JP2023509366A (en) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス, インコーポレイテッド | IRAK dissolving agents and their uses |
WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
CN115103841A (en) | 2019-12-23 | 2022-09-23 | 百时美施贵宝公司 | Substituted quinolinonyl piperazine compounds useful as T cell activators |
KR20220151160A (en) | 2019-12-23 | 2022-11-14 | 카이메라 쎄라퓨틱스 인코포레이티드 | SMARCA disintegrant and its uses |
MX2022007372A (en) | 2019-12-23 | 2022-07-12 | Bristol Myers Squibb Co | Substituted heteroaryl compounds useful as t cell activators. |
BR112022012179A2 (en) | 2019-12-23 | 2022-09-06 | Bristol Myers Squibb Co | SUBSTITUTED QUINAZOLINE COMPOUNDS USEFUL AS T-CELL ACTIVATORS |
AR120823A1 (en) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T-CELL ACTIVATORS |
AU2020412698A1 (en) | 2019-12-23 | 2022-08-18 | Bristol-Myers Squibb Company | Substituted piperazine derivatives useful as T cell activators |
BR112022013424A2 (en) | 2020-01-06 | 2022-12-13 | Hifibio Hk Ltd | ANTI-TNFR2 ANTIBODY AND ITS USES |
MX2022008421A (en) | 2020-01-07 | 2022-09-23 | Hifibio Hk Ltd | Anti-galectin-9 antibody and uses thereof. |
WO2021178488A1 (en) | 2020-03-03 | 2021-09-10 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
KR20220151189A (en) | 2020-03-09 | 2022-11-14 | 브리스톨-마이어스 스큅 컴퍼니 | Antibodies to CD40 with enhanced agonist activity |
CA3173831A1 (en) | 2020-03-19 | 2021-09-23 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
WO2021188948A1 (en) | 2020-03-19 | 2021-09-23 | Kymera Therapeutics, Inc. | Mdm2 degraders and uses thereof |
TW202140441A (en) | 2020-03-23 | 2021-11-01 | 美商必治妥美雅史谷比公司 | Substituted oxoisoindoline compounds |
EP4132971A1 (en) | 2020-04-09 | 2023-02-15 | Merck Sharp & Dohme LLC | Affinity matured anti-lap antibodies and uses thereof |
US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
MX2022015157A (en) | 2020-06-02 | 2023-01-16 | Arcus Biosciences Inc | Antibodies to tigit. |
TW202210483A (en) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Crystalline forms of irak degraders |
JP2023530456A (en) | 2020-06-17 | 2023-07-18 | アーカス バイオサイエンシズ インコーポレイティド | Crystal forms of CD73 inhibitors and uses thereof |
EP4178611A1 (en) | 2020-07-07 | 2023-05-17 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
CA3187255A1 (en) | 2020-07-30 | 2022-02-03 | Duncan Walker | Methods of treating mutant lymphomas |
JP2023537131A (en) | 2020-08-10 | 2023-08-30 | シャンハイ・シュンバイフイ・バイオテクノロジー・カンパニー・リミテッド | Compositions and methods for treating autoimmune diseases and cancer by targeting IGSF8 |
CA3186504A1 (en) | 2020-08-17 | 2022-02-24 | Stephen J. Blakemore | Bicycle conjugates specific for nectin-4 and uses thereof |
CN117015531A (en) | 2020-12-02 | 2023-11-07 | 医肯纳肿瘤学公司 | TEAD inhibitors and uses thereof |
WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
TW202245808A (en) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | Therapeutic rna for treating cancer |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
AU2022206395A1 (en) | 2021-01-11 | 2023-08-17 | Bicycletx Limited | Methods for treating cancer |
BR112023015584A2 (en) | 2021-02-02 | 2023-10-24 | Liminal Biosciences Ltd | GPR84 ANTAGONISTS AND USES THEREOF |
WO2022167457A1 (en) | 2021-02-02 | 2022-08-11 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
WO2022169921A1 (en) | 2021-02-04 | 2022-08-11 | Bristol-Myers Squibb Company | Benzofuran compounds as sting agonists |
IL304905A (en) | 2021-02-15 | 2023-10-01 | Kymera Therapeutics Inc | Irak4 degraders and uses thereof |
EP4301756A1 (en) | 2021-03-05 | 2024-01-10 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
WO2022197641A1 (en) | 2021-03-15 | 2022-09-22 | Rapt Therapeutics, Inc. | 1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine derivatives as hematopoietic progenitor kinase 1 (hpk1) modulators and/or inhibitors for the treatment of cancer and other diseases |
JP2024514530A (en) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Antibodies against truncated CDCP1 and uses thereof |
IL307338A (en) | 2021-04-05 | 2023-11-01 | Bristol Myers Squibb Co | Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer |
BR112023020077A2 (en) | 2021-04-06 | 2023-11-14 | Bristol Myers Squibb Co | OXOISOINDOLINE COMPOUNDS REPLACED BY PYRIDINYL |
CA3215081A1 (en) | 2021-04-16 | 2022-10-20 | Alfredo C. Castro | Mek inhibitors and uses thereof |
CN117295741A (en) | 2021-05-21 | 2023-12-26 | 艾库斯生物科学有限公司 | AXL compounds |
EP4341262A1 (en) | 2021-05-21 | 2024-03-27 | Arcus Biosciences, Inc. | Axl inhibitor compounds |
AU2022312698A1 (en) | 2021-07-13 | 2024-01-25 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
WO2023028238A1 (en) | 2021-08-25 | 2023-03-02 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
TW202315621A (en) | 2021-08-25 | 2023-04-16 | 美商皮克醫療公司 | Eif4e inhibitors and uses thereof |
TW202333802A (en) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | Therapeutic rna for lung cancer |
WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
WO2023150186A1 (en) | 2022-02-01 | 2023-08-10 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
WO2024028363A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Heteroaryl carboxamide and related gpr84 antagonists and uses thereof |
WO2024028364A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Aryl-triazolyl and related gpr84 antagonists and uses thereof |
WO2024036100A1 (en) | 2022-08-08 | 2024-02-15 | Bristol-Myers Squibb Company | Substituted tetrazolyl compounds useful as t cell activators |
WO2024036101A1 (en) | 2022-08-09 | 2024-02-15 | Bristol-Myers Squibb Company | Tertiary amine substituted bicyclic compounds useful as t cell activators |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JP2518911B2 (en) | 1987-10-23 | 1996-07-31 | 森永乳業株式会社 | Compositions and methods for the treatment of cancer characterized by overexpression of the c-fms protooncogene |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ATE195553T1 (en) | 1992-06-09 | 2000-09-15 | Chiron Corp | CRYSTALLIZATION OF M-CSF |
US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US6972323B1 (en) | 1997-04-01 | 2005-12-06 | Sankyo Company, Limited | Anti-Fas antibodies |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
WO1999029345A1 (en) | 1997-12-05 | 1999-06-17 | La Jolla Institute For Experimental Medicine | Inhibition of tumor growth by macrophage intervention |
AU6366999A (en) | 1998-10-30 | 2000-05-22 | Takeda Chemical Industries Ltd. | Betacellulin protein-containing preparations |
ES2197885T3 (en) | 1999-10-28 | 2004-01-16 | Hofbauer, Reinhold | USE OF CSF-1 INHIBITORS. |
WO2001034177A2 (en) | 1999-11-08 | 2001-05-17 | The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth & Human Services, The National Institutes Of Health | Method of treating a viral infection using antagonists of macrophage colony stimulating factor |
US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
US7455836B2 (en) | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
US6773895B2 (en) | 2000-09-01 | 2004-08-10 | Boehringer Ingelheim Pharma Kg | Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases |
US7247618B2 (en) | 2001-04-30 | 2007-07-24 | Tripathi Rajavashisth | Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling |
WO2002102972A2 (en) | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
JP4727992B2 (en) | 2002-11-15 | 2011-07-20 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
ES2393555T3 (en) | 2003-10-22 | 2012-12-26 | Keck Graduate Institute | Methods for the synthesis of hetero-multimeric polypeptides in yeasts using a haploid mating strategy. |
GB0325836D0 (en) | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
WO2005070447A2 (en) | 2004-01-21 | 2005-08-04 | Chiron Corporation | M-csf muteins and uses thereof |
US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
WO2005113596A2 (en) | 2004-05-14 | 2005-12-01 | Receptor Biologix, Inc. | Cell surface receptor isoforms and methods of identifying and using the same |
EP2287310B1 (en) | 2004-07-22 | 2015-05-06 | Five Prime Therapeutics, Inc. | Compositions and methods using MGD-CSF in disease treatment |
WO2006076288A2 (en) | 2005-01-11 | 2006-07-20 | Five Prime Therapeutics, Inc. | Dna constructs for long-term expression of intravascularly injected naked dna |
WO2006081430A2 (en) | 2005-01-27 | 2006-08-03 | Five Prime Therapeutics, Inc. | Leader sequences for directing secretion of polypeptides and methods for production thereof |
US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
WO2007064437A2 (en) | 2005-11-10 | 2007-06-07 | Receptor Biologix, Inc. | Methods for production of receptor and ligand isoforms |
WO2007075933A2 (en) | 2005-12-21 | 2007-07-05 | Cell Signaling Technology, Inc. | Translocation and mutant csf1r kinase in human leukemia |
EP1977238B1 (en) | 2005-12-22 | 2016-09-28 | Novartis AG | Soluble human m-csf receptor and uses thereof |
EP1984024A2 (en) | 2006-01-05 | 2008-10-29 | Novartis AG | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
WO2008042611A2 (en) | 2006-09-29 | 2008-04-10 | Centocor, Inc. | Method of using il6 antagonists with mitoxantrone for prostate cancer |
CA2669599A1 (en) | 2006-11-17 | 2008-05-22 | Biogen Idec Ma Inc. | Systemic administration of colony stimulating factors to treat amyloid associated disorders |
WO2008100995A1 (en) | 2007-02-14 | 2008-08-21 | Vaccinex, Inc. | Humanized anti-cd100 antibodies |
WO2008124858A2 (en) | 2007-04-11 | 2008-10-23 | F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. | Targeted receptor |
US20100298217A1 (en) | 2007-05-30 | 2010-11-25 | Evan Richard Stanley | Csf-1r mutants |
DK2188313T3 (en) | 2007-08-21 | 2017-12-11 | Amgen Inc | HUMAN C-FMS ANTI-BINDING PROTEINS |
US7981415B2 (en) | 2007-09-07 | 2011-07-19 | Cisthera, Inc. | Humanized PAI-1 antibodies |
WO2009058968A2 (en) | 2007-10-31 | 2009-05-07 | Janssen Pharmaceutica N.V. | Biomarker for assessing response to fms treatment |
EP2241333A1 (en) | 2007-12-12 | 2010-10-20 | National Cancer Center | Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof |
US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
JP5805393B2 (en) | 2008-03-14 | 2015-11-04 | トランジェーヌ、ソシエテ、アノニムTransgene S.A. | Antibody to CSF-1R |
US8242074B2 (en) * | 2008-09-12 | 2012-08-14 | Xbiotech, Inc. | Modulation of the amount or function of pathogenic CD14+CD16+ monocytes |
WO2010062401A2 (en) * | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using csf1r extracellular domain fusion molecules |
US8080246B2 (en) | 2008-11-26 | 2011-12-20 | Five Prime Therapeutics, Inc. | Colony stimulating factor 1 receptor (CSF1R) extracellular domain fusion molecules |
EP2504030A4 (en) * | 2009-11-24 | 2013-06-26 | Alderbio Holdings Llc | Antagonists of il-6 to raise albumin and/or lower crp |
HUE026201T2 (en) | 2009-12-10 | 2016-05-30 | Hoffmann La Roche | Antibodies binding to human CSF1R extracellular domain 4 and their use |
US9169323B2 (en) | 2010-03-05 | 2015-10-27 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
BR112012022046A2 (en) | 2010-03-05 | 2017-02-14 | F Hoffamann-La Roche Ag | "antibody, pharmaceutical composition, nucleic acid, expression vectors, host cell and method for producing a recombinant antibody". |
AR080698A1 (en) | 2010-04-01 | 2012-05-02 | Imclone Llc | ANTIBODY OR FRAGMENT OF THE SAME THAT SPECIFICALLY LINKS THE VARIOUS OF HUMAN CSF -1R, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER AND METHOD TO DETERMINE IF A BASED SUBJECT MATTER AND |
ES2820517T3 (en) * | 2010-05-04 | 2021-04-21 | Five Prime Therapeutics Inc | Antibodies that bind to CSF1R |
TW201307845A (en) * | 2010-12-13 | 2013-02-16 | Novartis Ag | Predictive methods and methods of treating arthritis using IL-17 antagonists |
WO2013057290A1 (en) | 2011-10-21 | 2013-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A m-dc8+ monocyte depleting agent for the prevention or the treatment of a condition associated with a chronic hyperactivation of the immune system |
CN103958546B (en) | 2011-10-21 | 2017-10-27 | 特朗斯吉有限公司 | The regulation of macrophage activation |
US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
KR20200011616A (en) | 2012-05-11 | 2020-02-03 | 파이브 프라임 테라퓨틱스, 인크. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csfir) |
CN104684582A (en) | 2012-08-31 | 2015-06-03 | 戊瑞治疗有限公司 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
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US20160326254A1 (en) | 2016-11-10 |
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TWI713436B (en) | 2020-12-21 |
BR112015004426A2 (en) | 2018-08-28 |
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US10221243B2 (en) | 2019-03-05 |
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KR20200140400A (en) | 2020-12-15 |
EP2890398A1 (en) | 2015-07-08 |
TW201919691A (en) | 2019-06-01 |
KR20150047593A (en) | 2015-05-04 |
TW201414492A (en) | 2014-04-16 |
IL237351B (en) | 2020-03-31 |
CN104684582A (en) | 2015-06-03 |
US20190248908A1 (en) | 2019-08-15 |
WO2014036357A1 (en) | 2014-03-06 |
JP2015533787A (en) | 2015-11-26 |
RU2015111563A (en) | 2016-10-20 |
AU2018204331A1 (en) | 2018-07-05 |
IL237351A0 (en) | 2015-04-30 |
US20210107986A1 (en) | 2021-04-15 |
US10822421B2 (en) | 2020-11-03 |
CA2882804A1 (en) | 2014-03-06 |
RU2718751C2 (en) | 2020-04-14 |
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