UY27304A1 - Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación - Google Patents
Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificaciónInfo
- Publication number
- UY27304A1 UY27304A1 UY27304A UY27304A UY27304A1 UY 27304 A1 UY27304 A1 UY 27304A1 UY 27304 A UY27304 A UY 27304A UY 27304 A UY27304 A UY 27304A UY 27304 A1 UY27304 A1 UY 27304A1
- Authority
- UY
- Uruguay
- Prior art keywords
- inhibitors
- methods
- macrophages
- migration
- identification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Se proveen inhibidores del MI que tienen utilidad en el tratamiento de una variedad de trastornos, incluido el tratamiento de condiciones patológicas asociadas con la actividad del MIF. Los inhibidores del MIF tienen las siguientes estructuras (Ia), (Ib), incluidos estereoisómeros, prodrogas y sales farmacéuticamente aceptables de los mismos, donde n, R1, R2, R3, R4, X, Y y Z son como se los define en el presente. También se proveen composiciones que contengan un inhibidor del MIF en combinación con un vehículo farmacéuticamente aceptable, así como métodos para su uso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29364201P | 2001-05-24 | 2001-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27304A1 true UY27304A1 (es) | 2002-12-31 |
Family
ID=23129922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27304A UY27304A1 (es) | 2001-05-24 | 2002-05-23 | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
Country Status (24)
Country | Link |
---|---|
US (14) | US7105519B2 (es) |
EP (1) | EP1389110B1 (es) |
JP (1) | JP4346312B2 (es) |
KR (1) | KR100896973B1 (es) |
CN (1) | CN1523989A (es) |
AR (1) | AR036032A1 (es) |
AT (1) | ATE461920T1 (es) |
AU (2) | AU2002303906B2 (es) |
BR (1) | BR0209948A (es) |
CA (1) | CA2447103A1 (es) |
CZ (1) | CZ20033503A3 (es) |
DE (1) | DE60235750D1 (es) |
ES (1) | ES2342877T3 (es) |
HU (1) | HUP0500101A3 (es) |
IL (1) | IL158550A0 (es) |
MX (1) | MXJL03000038A (es) |
MY (1) | MY140679A (es) |
NZ (1) | NZ529244A (es) |
PL (1) | PL367127A1 (es) |
PT (1) | PT1389110E (es) |
RU (1) | RU2327695C2 (es) |
UY (1) | UY27304A1 (es) |
WO (1) | WO2002094203A2 (es) |
ZA (1) | ZA200309738B (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2352228T3 (es) | 2001-03-29 | 2011-02-16 | Cytokine Pharmasciences, Inc. | Procedimiento y composiciones para usar el polipéptido de cadena invariante de mhc de clase ii como receptor para el factor inhibidor de la migración de macrófagos. |
UY27304A1 (es) * | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
AU2003235122A1 (en) | 2002-04-26 | 2003-11-10 | Takeda Chemical Industries, Ltd. | Cell death inhibitor |
AU2003247772A1 (en) * | 2002-06-27 | 2004-01-19 | Schering Aktiengesellschaft | Substituted quinoline ccr5 receptor antagonists |
TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
US7364869B2 (en) * | 2003-07-29 | 2008-04-29 | The J. David Gladstone Institutes | Method of detecting antigen-specific T lymphocytes |
CN1839133A (zh) * | 2003-08-22 | 2006-09-27 | 阿文尼尔药品公司 | 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 |
US7592466B2 (en) | 2003-10-09 | 2009-09-22 | Abbott Laboratories | Ureas having antiangiogenic activity |
AU2011265309B2 (en) * | 2003-11-21 | 2014-06-05 | Array Biopharma, Inc. | AKT protein kinase inhibitors |
CN1882347A (zh) | 2003-11-21 | 2006-12-20 | 阿雷生物药品公司 | Akt蛋白激酶抑制剂 |
AU2005228426B2 (en) * | 2004-03-29 | 2010-07-15 | North Shore-Long Island Jewish Research Institute | Treatment of type 1 diabetes with inhibitors of macrophage migration inhibitory factor |
DE102004029573A1 (de) * | 2004-06-18 | 2005-12-29 | Gambro Lundia Ab | MIF-Adsorbent |
WO2006031199A1 (en) * | 2004-09-17 | 2006-03-23 | Alex Poh Teck Choong | System and method for batch conversion of rfid tag to rfid label |
WO2006102191A1 (en) * | 2005-03-24 | 2006-09-28 | Avanir Pharmaceuticals | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors |
DK1928438T3 (da) * | 2005-09-26 | 2013-04-22 | Avigen Inc | Anvendelse af ibudilast til behandling af stofafhængighed |
GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
WO2007112036A2 (en) | 2006-03-24 | 2007-10-04 | The Feinstein Institute For Medical Research | Modified macrophage migration inhibitory factor inhibitors |
CN100457895C (zh) * | 2006-05-24 | 2009-02-04 | 中国科学院生物物理研究所 | 鼠抗人巨噬细胞迁移抑制因子单克隆抗体及其应用 |
US7622256B2 (en) * | 2006-05-31 | 2009-11-24 | Avigen, Inc. | Method for selecting compounds that modulate MIF-induced expression of ICAM-1 and/or VCAM-1 |
WO2007142923A1 (en) * | 2006-05-31 | 2007-12-13 | Avigen, Inc. | Mif inhibitors for treating neuropathic pain and associated syndromes |
US7845914B2 (en) * | 2007-02-15 | 2010-12-07 | Deere & Company | Self-priming fast fill sprayer pump system |
US9272034B2 (en) * | 2007-10-04 | 2016-03-01 | The Regents Of The University Of California | Treatment of conditions related to shock |
US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
EP2198879A1 (en) | 2008-12-11 | 2010-06-23 | Institut Curie | CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell |
WO2012009649A1 (en) * | 2010-07-16 | 2012-01-19 | Anderson Gaweco | Mif inhibitors and their uses |
WO2012031383A1 (zh) | 2010-09-06 | 2012-03-15 | 中国科学院广州生物医药与健康研究院 | 酰胺类化合物 |
EP2621521A4 (en) | 2010-10-02 | 2014-04-23 | Univ California | MINIMAL REDUCTION OF INTESTINAL DYSFUNCTION |
WO2013050453A1 (en) | 2011-10-07 | 2013-04-11 | Baxter Healthcare S.A. | Oxmif as a diagnostic marker |
KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
CA3095012C (en) | 2012-05-01 | 2023-02-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
WO2014200872A1 (en) | 2013-06-09 | 2014-12-18 | Rjs Biologics Llc | Pharmaceutical compounds targeted by mif affinity-tethered moieties |
US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
EP3327004B1 (en) * | 2015-07-17 | 2020-11-04 | Fujifilm Corporation | Nitrogen-containing heterocyclic compound |
CN111518076B (zh) * | 2018-01-17 | 2021-06-01 | 杭州阿诺生物医药科技有限公司 | 具有吲哚胺-2,3-双加氧酶(ido)抑制剂的制备方法 |
JP2021521173A (ja) | 2018-04-11 | 2021-08-26 | オハイオ・ステイト・イノベーション・ファウンデーション | 眼内薬物送達用の持続放出微粒子のための方法及び組成物 |
DK3774817T3 (da) | 2018-04-13 | 2023-02-13 | Cancer Research Tech Ltd | Bcl6-hæmmere |
DK3814348T3 (da) | 2018-06-27 | 2023-10-30 | Bristol Myers Squibb Co | Substituerede naphthyridinonforbindelser, der er anvendelige som t-celleaktivatorer |
EA202190137A1 (ru) | 2018-06-27 | 2021-05-17 | Бристол-Маерс Сквибб Компани | Нафтиридиноновые соединения для применения в качестве активаторов t-клеток |
AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
CN113121435B (zh) * | 2021-04-20 | 2022-08-30 | 辽宁大学 | 一种2,4-二氯喹啉类化合物的合成方法 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4324893A (en) | 1979-04-18 | 1982-04-13 | American Home Products Corporation | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives |
US4299814A (en) | 1979-05-25 | 1981-11-10 | Monsanto Company | Radioimmunoassay of MIF |
US4284768A (en) * | 1980-07-02 | 1981-08-18 | American Home Products Corporation | 1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives |
NZ211191A (en) | 1984-02-22 | 1988-01-08 | Wellcome Found | Cloning of dna for protozoal antigens |
US5733524A (en) | 1984-03-19 | 1998-03-31 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
US5869534A (en) | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
US5733933A (en) | 1984-03-19 | 1998-03-31 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
US5801200A (en) | 1984-03-19 | 1998-09-01 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
US5700447A (en) | 1992-05-21 | 1997-12-23 | The Picowder Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
AU592753B2 (en) | 1984-05-24 | 1990-01-25 | Ciba-Geigy Ag | Lymphokine in pure foem, novel monoclonal antibodies hybridoma cell lines, processes and applications |
JPH0672158B2 (ja) | 1984-05-24 | 1994-09-14 | チバ−ガイギ− アクチエンゲゼルシヤフト | 精製されたヒトマクロファージ遊走阻止因子 |
US4708937A (en) | 1984-10-15 | 1987-11-24 | Brigham & Women's Hospital | Purified migration inhibitory factor also having colony stimulating factor activity |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
GB8602626D0 (en) | 1986-02-04 | 1986-03-12 | Ciba Geigy Ag | Neurite-promoting factor |
ES2052602T3 (es) | 1986-10-03 | 1994-07-16 | Ciba Geigy Ag | Nuevos peptidos afines a las linfocinas. |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0463037A1 (en) | 1989-03-17 | 1992-01-02 | Genetics Institute, Inc. | Human macrophage migration inhibitory factor |
FI82144C (fi) | 1989-03-22 | 1991-01-10 | Wallac Oy | Foerfarande foer samtidig bestaemning av flera ligander. |
GB8915414D0 (en) | 1989-07-05 | 1989-08-23 | Ciba Geigy | Novel cytokines |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5328990A (en) | 1991-04-26 | 1994-07-12 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of macrophage migration inhibition factor from ocular lens |
CA2054602C (en) | 1991-10-31 | 2003-04-22 | Anthony Pawson | Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system |
US5624804A (en) | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
EP0702566B1 (en) | 1993-05-17 | 2010-07-21 | Cytokine Pharmasciences, Inc | Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity |
US6030615A (en) | 1993-05-17 | 2000-02-29 | The Picower Institute For Medical Research | Combination method for treating diseases caused by cytokine-mediated toxicity |
US6774227B1 (en) | 1993-05-17 | 2004-08-10 | Cytokine Pharmasciences, Inc. | Therapeutic uses of factors which inhibit or neutralize MIF activity |
US5650295A (en) | 1995-06-02 | 1997-07-22 | Human Genone Sciences, Inc. | Macrophage migration inhibitory factor-3 |
US6080408A (en) | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
SI9400363A (en) | 1994-09-19 | 1996-08-31 | Mozetic Francky Bojana | Human macrophage migration inhibitory factor of nonlymphoid origin, expression of mif in e. coli and purification of recombinant protein |
US5955203A (en) | 1994-10-05 | 1999-09-21 | Simpson Timber Company | Resin-coated overlays for solid substrates |
AU4365796A (en) | 1994-11-16 | 1996-06-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor |
DE19601697A1 (de) | 1996-01-18 | 1997-07-24 | Wacker Chemie Gmbh | Redispergierbare Tackifierpulver |
US6492428B1 (en) | 2000-07-26 | 2002-12-10 | The Picower Institute For Medical Research | Compounds having MIF antagonist activity |
US6420188B1 (en) | 1996-02-16 | 2002-07-16 | The Picower Institute For Medical Research | Screening assay for the identification of inhibitors for macrophage migration inhibitory factor |
US6599938B1 (en) * | 1999-10-29 | 2003-07-29 | The Picower Institute Of Medical Research | Compounds having MIF antagonist activity |
AU727108B2 (en) | 1996-04-18 | 2000-11-30 | Ariad Pharmaceuticals, Inc. | In vitro fluorescence polarization assay |
US5883224A (en) | 1996-04-19 | 1999-03-16 | Cytokine Sciences, Inc. | Characterization of transfer factors and methods of use |
US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
JPH1171351A (ja) * | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
US6413939B1 (en) | 1997-10-31 | 2002-07-02 | The Picower Institute For Medical Research | Inducible phosphofructokinase and the Warburg effect |
WO2000007007A1 (en) | 1998-07-28 | 2000-02-10 | Biometric Imaging, Inc. | Device and method for cell motility assay |
ES2353637T3 (es) * | 1998-08-07 | 2011-03-03 | Immunex Corporation | Moléculas denominadas ldcam. |
US6214343B1 (en) | 1999-05-24 | 2001-04-10 | Ophidian Pharmaceuticals, Inc. | Prevention and treatment of necrotizing enterocolitis |
CA2434671A1 (en) | 2001-01-12 | 2002-09-06 | The Picower Institute For Medical Research | Methods and compositions for modulating regulation of the cytotoxic lymphocyte response by macrophage migration inhibitory factor |
ES2352228T3 (es) | 2001-03-29 | 2011-02-16 | Cytokine Pharmasciences, Inc. | Procedimiento y composiciones para usar el polipéptido de cadena invariante de mhc de clase ii como receptor para el factor inhibidor de la migración de macrófagos. |
UY27304A1 (es) | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
CA2459224C (en) | 2001-09-03 | 2012-05-08 | Takeda Chemical Industries, Ltd. | 1,3-benzothiazinone derivatives and the use thereof |
FR2829491B1 (fr) | 2001-09-12 | 2005-09-30 | Diverchim | Procede de preparation des hydroxy-acides gras insatures et de leurs esters, leur utilisation comme agent anti-collagenase |
AU2002365941A1 (en) | 2001-12-05 | 2003-09-02 | North Shore-Long Island Jewish Research Institute | Methods of diagnosis, monitoring and treatment of fertility |
US20040019921A1 (en) | 2001-12-19 | 2004-01-29 | Fingerle-Rowson Gunter R. | Non-human mammal with disrupted or modified MIF gene, and uses thereof |
AU2003235122A1 (en) | 2002-04-26 | 2003-11-10 | Takeda Chemical Industries, Ltd. | Cell death inhibitor |
NZ537301A (en) | 2002-06-07 | 2006-06-30 | Cortical Pty Ltd | Therapeutic molecules and methods-1 |
US20060106102A1 (en) | 2002-06-07 | 2006-05-18 | Eric Morand | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) |
CA2497971A1 (en) | 2002-09-18 | 2004-04-01 | Pfizer Products Inc. | Triazole derivatives as transforming growth factor (tgf) inhibitors |
WO2004060881A1 (ja) | 2002-12-05 | 2004-07-22 | Takeda Pharmaceutical Company Limited | 1,3−ベンゾチアジノン誘導体、その製造法および用途 |
TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
US7361474B2 (en) | 2003-02-24 | 2008-04-22 | United States Of America As Represented By The Department Of Veterans Affairs | Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer |
CN1839133A (zh) | 2003-08-22 | 2006-09-27 | 阿文尼尔药品公司 | 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 |
WO2006102191A1 (en) | 2005-03-24 | 2006-09-28 | Avanir Pharmaceuticals | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors |
-
2002
- 2002-05-23 UY UY27304A patent/UY27304A1/es not_active Application Discontinuation
- 2002-05-23 MY MYPI20021922A patent/MY140679A/en unknown
- 2002-05-24 PL PL02367127A patent/PL367127A1/xx unknown
- 2002-05-24 HU HU0500101A patent/HUP0500101A3/hu unknown
- 2002-05-24 CA CA002447103A patent/CA2447103A1/en not_active Abandoned
- 2002-05-24 AR ARP020101966A patent/AR036032A1/es unknown
- 2002-05-24 JP JP2002590924A patent/JP4346312B2/ja not_active Expired - Fee Related
- 2002-05-24 AU AU2002303906A patent/AU2002303906B2/en not_active Ceased
- 2002-05-24 IL IL15855002A patent/IL158550A0/xx unknown
- 2002-05-24 US US10/156,650 patent/US7105519B2/en not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033503A patent/CZ20033503A3/cs unknown
- 2002-05-24 RU RU2003132534/04A patent/RU2327695C2/ru not_active IP Right Cessation
- 2002-05-24 ES ES02731971T patent/ES2342877T3/es not_active Expired - Lifetime
- 2002-05-24 MX MXJL03000038A patent/MXJL03000038A/es active IP Right Grant
- 2002-05-24 DE DE60235750T patent/DE60235750D1/de not_active Expired - Lifetime
- 2002-05-24 BR BR0209948-9A patent/BR0209948A/pt not_active Application Discontinuation
- 2002-05-24 KR KR1020037015359A patent/KR100896973B1/ko not_active IP Right Cessation
- 2002-05-24 NZ NZ529244A patent/NZ529244A/en unknown
- 2002-05-24 CN CNA02810501XA patent/CN1523989A/zh active Pending
- 2002-05-24 PT PT02731971T patent/PT1389110E/pt unknown
- 2002-05-24 WO PCT/US2002/016963 patent/WO2002094203A2/en active IP Right Grant
- 2002-05-24 EP EP02731971A patent/EP1389110B1/en not_active Expired - Lifetime
- 2002-05-24 AT AT02731971T patent/ATE461920T1/de active
-
2003
- 2003-12-17 ZA ZA200309738A patent/ZA200309738B/xx unknown
-
2005
- 2005-07-15 US US11/182,360 patent/US7514225B2/en not_active Expired - Fee Related
- 2005-07-15 US US11/182,241 patent/US7732146B2/en not_active Expired - Fee Related
- 2005-11-07 US US11/268,375 patent/US7084141B2/en not_active Expired - Fee Related
-
2006
- 2006-01-31 US US11/344,938 patent/US7202248B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,842 patent/US7238809B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,628 patent/US7192961B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,552 patent/US7235565B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/416,004 patent/US7157469B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,785 patent/US7192955B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/415,998 patent/US7129236B2/en not_active Expired - Fee Related
- 2006-05-02 US US11/416,165 patent/US7230106B2/en not_active Expired - Fee Related
- 2006-12-07 US US11/635,319 patent/US7435737B2/en not_active Expired - Fee Related
-
2007
- 2007-03-16 US US11/687,611 patent/US7432374B2/en not_active Expired - Fee Related
- 2007-04-04 AU AU2007201493A patent/AU2007201493A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY27304A1 (es) | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación | |
UY28187A1 (es) | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación | |
UY28483A1 (es) | Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migración de macrófagos y su uso en el tratamiento de enfermedades en el hombre | |
UY28514A1 (es) | Nuevos compuestos | |
ECSP055864A (es) | Derivados sustituidos del pirrolo-pirazol como inhibidores de la quinasa | |
UY27222A1 (es) | Pirazolopirimidinas como agentes terapéuticos | |
ECSP034750A (es) | Derivados de espirociclicos nuevos y su uso como inhibidores de fosfodiesterasa-7 | |
UY29246A1 (es) | Nuevos compuestos | |
UY27729A1 (es) | Inhibidores de quinasas. | |
SV2010003567A (es) | Derivados bis-(sulfonilamino) en terapia 066 | |
PA8501801A1 (es) | Inhibidores triciclicos de polimerasas (adp - polirribosas) | |
UY26958A1 (es) | Nuevos agentes anticolinérgicos que se pueden emplear como medicamentos así como procedimiento para su preparación | |
ECSP044992A (es) | Inhibidores de la alquín-aril fosfodiesterasa-4 | |
ES2192213T3 (es) | Arilalquil-diazinonas como inhibidores de fosfodiesterasa iv. | |
UY27774A1 (es) | Inhibidores de metaloproteinas de triaril-oxi-aril-espiropirimidina-2,4,6-triona | |
UY27872A1 (es) | Inhibidores de caspasa y usos de los mismos. | |
UY28360A1 (es) | Nuevos compuestos | |
AR024998A1 (es) | Nuevos retinoides para el tratamiento del enfisema | |
AR025351A1 (es) | Agonistas retinoides selectivos par | |
SE0202461D0 (sv) | Novel compounds | |
AR045727A1 (es) | Fluorocombretastatina y derivados de la misma | |
SE9904676D0 (sv) | Novel compounds | |
ATE491709T1 (de) | Pyrrolidinohydrochinazoline | |
SE9901901D0 (sv) | Compounds | |
UY27560A1 (es) | Compuestos hexaciclicos- |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20141202 |