BRPI0408784A - método para usar um composto - Google Patents

método para usar um composto

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Publication number
BRPI0408784A
BRPI0408784A BRPI0408784-4A BRPI0408784A BRPI0408784A BR PI0408784 A BRPI0408784 A BR PI0408784A BR PI0408784 A BRPI0408784 A BR PI0408784A BR PI0408784 A BRPI0408784 A BR PI0408784A
Authority
BR
Brazil
Prior art keywords
compound
condition
administering
patient
treating
Prior art date
Application number
BRPI0408784-4A
Other languages
English (en)
Inventor
Yoshitaka Satoh
Shripad S Bhagwat
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of BRPI0408784A publication Critical patent/BRPI0408784A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D491/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
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  • Oncology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"MéTODO PARA USAR UM COMPOSTO". Esta invenção no geral diz respeito a métodos para tratar ou prevenir uma condição responsiva à inibição de JNK, tal como uma condição metabólica, que compreende administrar a um paciente em necessidade deste uma quantidade eficaz de um Derivado de Anilinopirimidina tendo a seguinte estrutura (I) ou um sal deste farmaceuticamente aceitável, em que R~ 1~ até R~ 6~ são como aqui definidos.
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US10/395,811 US7429599B2 (en) 2000-12-06 2003-03-24 Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
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AU2004224302A1 (en) 2004-10-07
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EP1608375A1 (en) 2005-12-28
JP2006521394A (ja) 2006-09-21
US7429599B2 (en) 2008-09-30
MXPA05010185A (es) 2005-11-08
CA2520440A1 (en) 2004-10-07
NZ543052A (en) 2009-01-31
KR20060025131A (ko) 2006-03-20
US20040106634A1 (en) 2004-06-03
CN1791410A (zh) 2006-06-21

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