EP1390052A4 - Inhibition of jun kinase - Google Patents

Inhibition of jun kinase

Info

Publication number
EP1390052A4
EP1390052A4 EP02764295A EP02764295A EP1390052A4 EP 1390052 A4 EP1390052 A4 EP 1390052A4 EP 02764295 A EP02764295 A EP 02764295A EP 02764295 A EP02764295 A EP 02764295A EP 1390052 A4 EP1390052 A4 EP 1390052A4
Authority
EP
European Patent Office
Prior art keywords
inhibition
jun kinase
kinase
jun
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP02764295A
Other languages
German (de)
French (fr)
Other versions
EP1390052A1 (en
Inventor
Gokhan S Hotamisligil
Michael Karin
Lufen Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
University of California
Original Assignee
Harvard College
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, University of California filed Critical Harvard College
Publication of EP1390052A1 publication Critical patent/EP1390052A1/en
Publication of EP1390052A4 publication Critical patent/EP1390052A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02764295A 2001-04-24 2002-04-24 Inhibition of jun kinase Ceased EP1390052A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28596601P 2001-04-24 2001-04-24
US285966P 2001-04-24
PCT/US2002/012687 WO2002085396A1 (en) 2001-04-24 2002-04-24 Inhibition of jun kinase

Publications (2)

Publication Number Publication Date
EP1390052A1 EP1390052A1 (en) 2004-02-25
EP1390052A4 true EP1390052A4 (en) 2008-10-08

Family

ID=23096452

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02764295A Ceased EP1390052A4 (en) 2001-04-24 2002-04-24 Inhibition of jun kinase

Country Status (3)

Country Link
EP (1) EP1390052A4 (en)
CA (1) CA2477842A1 (en)
WO (1) WO2002085396A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072888A1 (en) 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
US7119114B1 (en) 1999-08-19 2006-10-10 Signal Pharmaceuticals, Llc Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US7429599B2 (en) 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US6987184B2 (en) 2001-02-15 2006-01-17 Signal Pharmaceuticals, Llc Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related
CA2546493A1 (en) 2003-11-19 2005-06-09 Signal Pharmaceuticals, Llc Indazole compounds and methods of use thereof as protein kinase inhibitors
JP4686704B2 (en) 2004-08-24 2011-05-25 国立大学法人山口大学 Aneurysm prophylactic and / or therapeutic agent
CN101056656A (en) * 2004-09-15 2007-10-17 哈佛大学校长及研究员协会 Reducing ER stress in the treatment of obesity and diabetes
US20060223807A1 (en) 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
WO2008016995A2 (en) * 2006-08-01 2008-02-07 Joslin Diabetes Center, Inc. Methods of identifying modulators of insulin signalling
US20080194575A1 (en) * 2006-10-04 2008-08-14 Naiara Beraza Treatment for non-alcoholic-steatohepatitis
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
CN102676466A (en) * 2011-03-17 2012-09-19 南京大学 Mutant jun N-terminal 1 (JNK1) sequence and plasmid application thereof
WO2015048331A1 (en) 2013-09-25 2015-04-02 Cornell University Compounds for inducing anti-tumor immunity and methods thereof
US10036018B2 (en) 2014-03-10 2018-07-31 Carlo M. Croce Compositions and methods for treating cachexia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053927A1 (en) * 1998-04-17 1999-10-28 Trustees Of Tufts College Methods for treating and preventing insulin resistance and related disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2160371A1 (en) * 1993-04-16 1994-10-27 The Trustees Of Tufts College Method for treatment of menopausal and premenstrual symptoms
US5506211A (en) * 1994-05-09 1996-04-09 The Uab Research Foundation Genistein for use in inhibiting osteroclasts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053927A1 (en) * 1998-04-17 1999-10-28 Trustees Of Tufts College Methods for treating and preventing insulin resistance and related disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AGUIRRE V; UCHIDA T; YENUSH L; DAVIS R; WHITE M F: "The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 12, 24 March 2000 (2000-03-24), pages 9047 - 9054, XP002493212, ISSN: 0021-9258 *
BENNETT B ET AL: "A SELECTIVE INHIBITOR OF JNK THAT MODULATES THE ACTIVATION AND DIFFERENTIATION OF CD4+ CELLS", IMFLAMMATION RESEARCH, BIRKHAEUSER VERLAG, BASEL, vol. 49, no. SUPPL. 02, 1 August 2000 (2000-08-01), pages S102, XP008014580, ISSN: 1023-3830 *
See also references of WO02085396A1 *

Also Published As

Publication number Publication date
EP1390052A1 (en) 2004-02-25
CA2477842A1 (en) 2002-10-31
WO2002085396A1 (en) 2002-10-31

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Legal Events

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Inventor name: CHANG, LUFEN

Inventor name: KARIN, MICHAEL

Inventor name: HOTAMISLIGIL, GOKHAN, S.

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Effective date: 20080905

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