BRPI0406883A - Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto - Google Patents
Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um compostoInfo
- Publication number
- BRPI0406883A BRPI0406883A BR0406883-1A BRPI0406883A BRPI0406883A BR PI0406883 A BRPI0406883 A BR PI0406883A BR PI0406883 A BRPI0406883 A BR PI0406883A BR PI0406883 A BRPI0406883 A BR PI0406883A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treating
- disorder
- pharmaceutical composition
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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- C07F7/08—Compounds having one or more C—Si linkages
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
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- Immunology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
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- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Transplantation (AREA)
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- Child & Adolescent Psychology (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO DE TRATAR UM DISTúRBIO, E, USO DE UM COMPOSTO". A presente invenção fornece um composto da fórmula I ou um sal farmaceuticamente aceitável deste, composições farmacêuticas que compreendem uma quantidade eficaz de um composto da Fórmula I em combinação com um veículo, diluente ou excipiente adequados e, métodos para tratar distúrbios fisiológicos, particularmente doença congestiva cardíaca, que compreende administrar a um paciente em necessidade deste, uma quantidade eficaz de um composto da Fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44194703P | 2003-01-22 | 2003-01-22 | |
PCT/US2004/000017 WO2004067529A1 (en) | 2003-01-22 | 2004-01-20 | Indole-derivative modulators of steroid hormone nuclear receptors |
Publications (1)
Publication Number | Publication Date |
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BRPI0406883A true BRPI0406883A (pt) | 2006-01-03 |
Family
ID=32825176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0406883-1A BRPI0406883A (pt) | 2003-01-22 | 2004-01-20 | Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto |
Country Status (9)
Country | Link |
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US (1) | US20060235222A1 (pt) |
EP (1) | EP1597254A1 (pt) |
JP (1) | JP2007500253A (pt) |
CN (1) | CN1742007A (pt) |
AU (1) | AU2004207740A1 (pt) |
BR (1) | BRPI0406883A (pt) |
CA (1) | CA2511806A1 (pt) |
MX (1) | MXPA05007857A (pt) |
WO (1) | WO2004067529A1 (pt) |
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EP1723105B1 (en) | 2004-03-03 | 2013-05-15 | Eli Lilly And Company | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators |
DE102004021637A1 (de) * | 2004-05-03 | 2005-12-01 | Merck Patent Gmbh | Dihydrobenzothiophene |
EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
CN101321726A (zh) * | 2005-09-30 | 2008-12-10 | 大日本住友制药株式会社 | 新型稠合吡咯衍生物 |
TWI385161B (zh) | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
JP5099814B2 (ja) * | 2006-02-02 | 2012-12-19 | 田辺三菱製薬株式会社 | 含窒素複素二環式化合物 |
RS20090208A (en) | 2006-10-31 | 2010-06-30 | Pfizer Products Inc. | Pyrazoline compounds as mineralocorticoid receptor antagonists |
JP2010138072A (ja) * | 2007-03-29 | 2010-06-24 | Dainippon Sumitomo Pharma Co Ltd | 新規な縮合ピロール誘導体 |
CN101801965B (zh) * | 2007-08-17 | 2014-07-30 | 株式会社Lg生命科学 | 作为细胞坏死抑制剂的吲哚化合物 |
DE102008030207A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
WO2011137220A1 (en) * | 2010-04-28 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Small molecule neuropeptide s antagonists for the treatment of addictive disorders, mood, anxiety and sleep disorders |
EP3238781B1 (en) | 2010-05-10 | 2019-07-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
WO2011153192A2 (en) * | 2010-06-01 | 2011-12-08 | Angion Biomedica Corp. | Cytochrome p450 inhibitors and uses thereof |
US10414760B2 (en) | 2016-11-29 | 2019-09-17 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
JP6180930B2 (ja) | 2010-06-16 | 2017-08-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 創傷治癒過程における再上皮化を刺激するための方法及び組成物 |
US8933113B2 (en) * | 2011-01-20 | 2015-01-13 | Merck Sharp & Dohme Corp. | Mineralocorticoid receptor antagonists |
WO2012139495A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | Mineralocorticoid receptor antagonists |
AR091731A1 (es) * | 2012-07-19 | 2015-02-25 | Merck Sharp & Dohme | Antagonistas del receptor de mineralocorticoides |
EP2935284A4 (en) * | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
US9988374B2 (en) | 2014-08-11 | 2018-06-05 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
WO2016094260A1 (en) | 2014-12-10 | 2016-06-16 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
JP2018501279A (ja) | 2014-12-31 | 2018-01-18 | アンギオン バイオメディカ コーポレイション | 疾患を治療するための方法及び薬剤 |
ES2906778T3 (es) | 2015-03-30 | 2022-04-20 | Corcept Therapeutics Inc | Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal |
CN107922396B (zh) * | 2015-07-20 | 2022-08-05 | 建新公司 | 集落刺激因子-1受体(csf-1r)抑制剂 |
CN109053736A (zh) * | 2018-08-08 | 2018-12-21 | 青岛科技大学 | 一种吡咯并[1,2-α]吲哚-3-醇衍生物的制备方法 |
CN109293550B (zh) * | 2018-11-23 | 2020-09-25 | 南京林业大学 | 一种含三氟甲基3,6’-非对称双吲哚化合物及其合成方法 |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
CN115894330A (zh) * | 2022-09-06 | 2023-04-04 | 吉林医药学院 | 一种1-乙酰基-1h-吲哚-3-基乙酸酯衍生物的合成方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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DE2750283C2 (de) * | 1977-11-10 | 1985-08-22 | Bayer Ag, 5090 Leverkusen | Druck- und wärmeempfindliches Aufzeichnungsmaterial |
JPS62503194A (ja) * | 1985-07-03 | 1987-12-17 | ポラロイド コ−ポレ−シヨン | カラー拡散転写写真フィルム単位 |
US5041547A (en) * | 1986-08-28 | 1991-08-20 | Appleton Papers Inc. | Chromogenic substituted 4,7-diazaphthalides |
GB9609641D0 (en) * | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
CN1492863A (zh) * | 2000-12-22 | 2004-04-28 | 作为5-羟色胺-6配基的杂环基烷基-吲哚或氮杂吲哚化合物 |
-
2004
- 2004-01-20 CN CNA2004800026858A patent/CN1742007A/zh active Pending
- 2004-01-20 JP JP2006536489A patent/JP2007500253A/ja active Pending
- 2004-01-20 BR BR0406883-1A patent/BRPI0406883A/pt not_active IP Right Cessation
- 2004-01-20 US US10/542,621 patent/US20060235222A1/en not_active Abandoned
- 2004-01-20 WO PCT/US2004/000017 patent/WO2004067529A1/en active Application Filing
- 2004-01-20 MX MXPA05007857A patent/MXPA05007857A/es unknown
- 2004-01-20 AU AU2004207740A patent/AU2004207740A1/en not_active Abandoned
- 2004-01-20 CA CA002511806A patent/CA2511806A1/en not_active Abandoned
- 2004-01-20 EP EP04703558A patent/EP1597254A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
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CA2511806A1 (en) | 2004-08-12 |
CN1742007A (zh) | 2006-03-01 |
MXPA05007857A (es) | 2005-10-18 |
JP2007500253A (ja) | 2007-01-11 |
US20060235222A1 (en) | 2006-10-19 |
WO2004067529A1 (en) | 2004-08-12 |
EP1597254A1 (en) | 2005-11-23 |
AU2004207740A1 (en) | 2004-08-12 |
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