BR0113590A - 7-oxo-piridopirimidinas - Google Patents
7-oxo-piridopirimidinasInfo
- Publication number
- BR0113590A BR0113590A BR0113590-2A BR0113590A BR0113590A BR 0113590 A BR0113590 A BR 0113590A BR 0113590 A BR0113590 A BR 0113590A BR 0113590 A BR0113590 A BR 0113590A
- Authority
- BR
- Brazil
- Prior art keywords
- oxopyridopyrimidines
- oxypyropyrypyrimidines
- prodrug
- disorders
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
"7-OXO-PIRIDOPIRIMIDINAS". A presente invenção fornece compostos da fórmula (I), uma prodroga ou um sal farmaceuticamente aceitável do mesmo, em que R^ 1^, R^ 2^, R^ 3^ e Ar^ 1^ são os definidos no presente, e processos para sua preparação e seu uso para o tratamento de distúrbios causados por p38.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22957700P | 2000-08-31 | 2000-08-31 | |
PCT/EP2001/009688 WO2002018379A2 (en) | 2000-08-31 | 2001-08-22 | 7-oxo pyridopyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0113590A true BR0113590A (pt) | 2003-07-22 |
Family
ID=22861834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0113590-2A BR0113590A (pt) | 2000-08-31 | 2001-08-22 | 7-oxo-piridopirimidinas |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1315727B1 (pt) |
JP (1) | JP4146721B2 (pt) |
KR (1) | KR100582325B1 (pt) |
CN (2) | CN1303072C (pt) |
AR (1) | AR033996A1 (pt) |
AT (1) | ATE298751T1 (pt) |
AU (2) | AU2002212147B2 (pt) |
BR (1) | BR0113590A (pt) |
CA (1) | CA2420122A1 (pt) |
DE (1) | DE60111752T2 (pt) |
ES (1) | ES2243568T3 (pt) |
GT (1) | GT200100190A (pt) |
MX (1) | MXPA03001733A (pt) |
PA (1) | PA8527401A1 (pt) |
PE (1) | PE20020524A1 (pt) |
UY (1) | UY26920A1 (pt) |
WO (1) | WO2002018379A2 (pt) |
ZA (1) | ZA200301078B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7629350B2 (en) * | 2002-04-19 | 2009-12-08 | Smithkline Beecham Corporation | Compounds |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
US20070020234A1 (en) * | 2003-07-07 | 2007-01-25 | Vande Woude George F | Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor |
WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
MXPA06014486A (es) * | 2004-06-15 | 2007-03-01 | Pfizer | Derivados de acido carboxilico de bencimidazolona. |
WO2006115237A1 (ja) * | 2005-04-25 | 2006-11-02 | Ube Industries, Ltd. | 4-アミノ-2-アルキルチオ-5-ピリミジンカルバルデヒドの製法 |
JP2006321749A (ja) * | 2005-05-19 | 2006-11-30 | Ube Ind Ltd | 2−シアノマロンアルデヒドのアルカリ金属塩の製法 |
CA2636981A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
WO2008055842A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
EP2158182A2 (en) | 2007-06-15 | 2010-03-03 | F. Hoffmann-Roche AG | A novel process for the preparation of 3-amino-pentan-1,5-diol |
JP2013507395A (ja) * | 2009-10-09 | 2013-03-04 | アフラクシス・インコーポレイテッド | Cns障害治療用の8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン |
US20120184542A1 (en) | 2011-01-19 | 2012-07-19 | Kevin Anderson | Pyrido pyrimidines |
CN104428298B (zh) * | 2012-03-22 | 2017-03-01 | 奥斯克技术有限公司 | 取代的吡啶并嘧啶化合物及其作为flt3抑制剂的用途 |
TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
US9663524B2 (en) | 2013-03-15 | 2017-05-30 | Celgene Car Llc | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors |
PL3691620T3 (pl) | 2017-10-05 | 2022-11-21 | Fulcrum Therapeutics, Inc. | Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
JP7152794B2 (ja) * | 2018-09-14 | 2022-10-13 | アビスコ セラピューティクス カンパニー リミテッド | Fgfr阻害剤、その製造方法および応用 |
CN115960098A (zh) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6183168A (ja) * | 1984-09-28 | 1986-04-26 | Ube Ind Ltd | 2−メルカプト−4−アミノ−5−ホルミルピリミジンおよびその製法 |
IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
AU706818B2 (en) * | 1996-05-20 | 1999-06-24 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
KR100571339B1 (ko) * | 2000-08-31 | 2006-04-17 | 에프. 호프만-라 로슈 아게 | 세포증식 억제제로서의 7-옥소 피리도피리미딘 |
-
2001
- 2001-08-22 DE DE60111752T patent/DE60111752T2/de not_active Expired - Fee Related
- 2001-08-22 CA CA002420122A patent/CA2420122A1/en not_active Abandoned
- 2001-08-22 AT AT01980258T patent/ATE298751T1/de not_active IP Right Cessation
- 2001-08-22 MX MXPA03001733A patent/MXPA03001733A/es active IP Right Grant
- 2001-08-22 JP JP2002523894A patent/JP4146721B2/ja not_active Expired - Fee Related
- 2001-08-22 WO PCT/EP2001/009688 patent/WO2002018379A2/en not_active Application Discontinuation
- 2001-08-22 EP EP01980258A patent/EP1315727B1/en not_active Expired - Lifetime
- 2001-08-22 AU AU2002212147A patent/AU2002212147B2/en not_active Ceased
- 2001-08-22 KR KR1020037002955A patent/KR100582325B1/ko not_active IP Right Cessation
- 2001-08-22 ES ES01980258T patent/ES2243568T3/es not_active Expired - Lifetime
- 2001-08-22 AU AU1214702A patent/AU1214702A/xx active Pending
- 2001-08-22 BR BR0113590-2A patent/BR0113590A/pt not_active Application Discontinuation
- 2001-08-22 CN CNB2005100835295A patent/CN1303072C/zh not_active Expired - Fee Related
- 2001-08-22 CN CNB018150276A patent/CN100358892C/zh not_active Expired - Fee Related
- 2001-08-28 PA PA20018527401A patent/PA8527401A1/es unknown
- 2001-08-28 PE PE2001000861A patent/PE20020524A1/es not_active Application Discontinuation
- 2001-08-30 UY UY26920A patent/UY26920A1/es not_active Application Discontinuation
- 2001-08-30 AR ARP010104131A patent/AR033996A1/es unknown
- 2001-09-18 GT GT200100190A patent/GT200100190A/es unknown
-
2003
- 2003-02-07 ZA ZA200301078A patent/ZA200301078B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR100582325B1 (ko) | 2006-05-22 |
CA2420122A1 (en) | 2002-03-07 |
CN1451004A (zh) | 2003-10-22 |
PA8527401A1 (es) | 2002-07-30 |
ES2243568T3 (es) | 2005-12-01 |
AU2002212147B2 (en) | 2007-10-18 |
GT200100190A (es) | 2002-05-23 |
ZA200301078B (en) | 2004-05-07 |
AU1214702A (en) | 2002-03-13 |
JP4146721B2 (ja) | 2008-09-10 |
DE60111752D1 (de) | 2005-08-04 |
PE20020524A1 (es) | 2002-06-18 |
DE60111752T2 (de) | 2006-05-04 |
EP1315727A2 (en) | 2003-06-04 |
CN1721412A (zh) | 2006-01-18 |
JP2004507540A (ja) | 2004-03-11 |
MXPA03001733A (es) | 2003-05-27 |
WO2002018379A2 (en) | 2002-03-07 |
WO2002018379A3 (en) | 2002-07-25 |
UY26920A1 (es) | 2002-02-28 |
ATE298751T1 (de) | 2005-07-15 |
CN100358892C (zh) | 2008-01-02 |
EP1315727B1 (en) | 2005-06-29 |
KR20030022423A (ko) | 2003-03-15 |
AR033996A1 (es) | 2004-01-21 |
CN1303072C (zh) | 2007-03-07 |
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