US3387001A
(en)
|
1964-10-19 |
1968-06-04 |
Lilly Co Eli |
Novel aminoacyl esters of desacetyl vincaleukoblastine
|
US3619371A
(en)
*
|
1967-07-03 |
1971-11-09 |
Nat Res Dev |
Production of a polymeric matrix having a biologically active substance bound thereto
|
SE343210B
(de)
*
|
1967-12-20 |
1972-03-06 |
Pharmacia Ab |
|
US3742955A
(en)
*
|
1970-09-29 |
1973-07-03 |
Fmc Corp |
Fibrous collagen derived product having hemostatic and wound binding properties
|
US3894000A
(en)
|
1971-01-27 |
1975-07-08 |
Upjohn Co |
Ara-cytidine derivatives and process of preparation
|
US4066650A
(en)
|
1971-02-11 |
1978-01-03 |
Egyud Laszlo G |
Keto-aldehyde-amine addition products and method of making same
|
CA955937A
(en)
|
1971-06-28 |
1974-10-08 |
Shionogi And Co. Ltd. |
Cyclic phosphamide derivatives
|
US3810473A
(en)
*
|
1972-12-04 |
1974-05-14 |
Avicon Inc |
Liquid-laid, non-woven, fibrous collagen derived surgical web having hemostatic and wound sealing properties
|
US3876501A
(en)
*
|
1973-05-17 |
1975-04-08 |
Baxter Laboratories Inc |
Binding enzymes to activated water-soluble carbohydrates
|
US3991045A
(en)
|
1973-05-30 |
1976-11-09 |
Asahi Kasei Kogyo Kabushiki Kaisha |
N4 -acylarabinonucleosides
|
GB1479268A
(en)
*
|
1973-07-05 |
1977-07-13 |
Beecham Group Ltd |
Pharmaceutical compositions
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
DE2360794C2
(de)
*
|
1973-12-06 |
1984-12-06 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur Herstellung von Peptiden
|
GB1529974A
(en)
|
1974-10-15 |
1978-10-25 |
Asahi Chemical Ind |
Nucleotide derivatives and process for preparing the same
|
US4012390A
(en)
|
1974-10-16 |
1977-03-15 |
Eli Lilly And Company |
Vinblastinoic acid
|
US3949073A
(en)
*
|
1974-11-18 |
1976-04-06 |
The Board Of Trustees Of Leland Stanford Junior University |
Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
|
CH596313A5
(de)
*
|
1975-05-30 |
1978-03-15 |
Battelle Memorial Institute |
|
US4279817A
(en)
|
1975-05-30 |
1981-07-21 |
The United States Of America As Represented By The Department Of Health & Human Services |
Method for producing dimer alkaloids
|
IL47468A
(en)
*
|
1975-06-12 |
1979-05-31 |
Rehovot Res Prod |
Process for the cross-linking of proteins using water soluble cross-linking agents
|
US4233360A
(en)
|
1975-10-22 |
1980-11-11 |
Collagen Corporation |
Non-antigenic collagen and articles of manufacture
|
US4488911A
(en)
|
1975-10-22 |
1984-12-18 |
Luck Edward E |
Non-antigenic collagen and articles of manufacture
|
US4057548A
(en)
|
1975-11-11 |
1977-11-08 |
Jacek Wiecko |
Process for preparing methotrexate or an N-substituted derivative thereof and/or a di (lower) alkyl ester thereof and precursor therefor
|
JPS5289680A
(en)
|
1976-01-22 |
1977-07-27 |
Mitsui Toatsu Chem Inc |
Preparation of 1-(2-tetrahydrofuryl)-5-flurouracil
|
US4002531A
(en)
*
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
AT352867B
(de)
*
|
1976-05-12 |
1979-10-10 |
Battelle Institut E V |
Knochenersatz-knochenverbund-oder prothesen- verankerungswerkstoff und verfahren zu seiner herstellung
|
DE2623420C2
(de)
|
1976-05-25 |
1978-07-06 |
Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg |
Verfahren zur Herstellung unsymmetrisch 13-disubstituierter Nitrosoharnstoffe
|
GB1578348A
(en)
*
|
1976-08-17 |
1980-11-05 |
Pharmacia Ab |
Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic
|
US4258052A
(en)
|
1976-08-17 |
1981-03-24 |
Yu Ruey J |
Treatment of psoriasis with nicotinamide analogues
|
USRE30561E
(en)
|
1976-12-06 |
1981-03-31 |
Eli Lilly And Company |
Vinca alkaloid intermediates
|
JPS5395917A
(en)
|
1977-02-03 |
1978-08-22 |
Tokyo Tanabe Co |
Process for preparing nitrosourea derivative of glucopyranose
|
JPS53149985A
(en)
|
1977-05-31 |
1978-12-27 |
Asahi Chem Ind Co Ltd |
Preparation of 5-fluorouracil derivatives
|
US4164559A
(en)
*
|
1977-09-21 |
1979-08-14 |
Cornell Research Foundation, Inc. |
Collagen drug delivery device
|
SE7903361L
(sv)
|
1978-04-20 |
1979-10-21 |
Johnson Matthey Co Ltd |
Kompositioner innehallande platina
|
US4404970A
(en)
*
|
1978-05-19 |
1983-09-20 |
Sawyer Philip Nicholas |
Hemostatic article and methods for preparing and employing the same
|
US4238480A
(en)
|
1978-05-19 |
1980-12-09 |
Sawyer Philip Nicholas |
Method for preparing an improved hemostatic agent and method of employing the same
|
US4390519A
(en)
*
|
1978-05-19 |
1983-06-28 |
Sawyer Philip Nicholas |
Bandage with hemostatic agent and methods for preparing and employing the same
|
US4215062A
(en)
|
1978-05-22 |
1980-07-29 |
University Of Kansas Endowment Association |
Anthracycline synthesis
|
US4296105A
(en)
|
1978-08-03 |
1981-10-20 |
Institut International De Pathologie Cellulaire Et Moleculaire |
Derivatives of doxorubicine, their preparation and use
|
US4259242A
(en)
|
1978-10-10 |
1981-03-31 |
Eli Lilly And Company |
Method of preparing vindesine sulfate
|
JPS5559173A
(en)
|
1978-10-27 |
1980-05-02 |
Kaken Pharmaceut Co Ltd |
Novel fluorouracil derivative
|
US4210584A
(en)
|
1979-01-15 |
1980-07-01 |
Eli Lilly And Company |
Vindesine synthesis
|
JPS6023084B2
(ja)
*
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
US4279812A
(en)
*
|
1979-09-12 |
1981-07-21 |
Seton Company |
Process for preparing macromolecular biologically active collagen
|
US4412947A
(en)
|
1979-09-12 |
1983-11-01 |
Seton Company |
Collagen sponge
|
US4371540A
(en)
|
1979-09-14 |
1983-02-01 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
|
DE2943520C2
(de)
*
|
1979-10-27 |
1982-05-19 |
Fa. Carl Freudenberg, 6940 Weinheim |
Verfahren zur Herstellung von Kollagenschwamm für medizinische oder kosmetische Zwecke
|
US4639456A
(en)
|
1980-06-10 |
1987-01-27 |
Omnichem S.A. |
Vinblastin-23-oyl amino acid derivatives
|
US4374414A
(en)
|
1980-06-26 |
1983-02-15 |
Gte Automatic Electric Labs Inc. |
Arbitration controller providing for access of a common resource by a duplex plurality of central processing units
|
CS216992B1
(en)
*
|
1980-07-21 |
1982-12-31 |
Miroslav Stol |
Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
|
US4299778A
(en)
|
1980-07-21 |
1981-11-10 |
Shell Oil Company |
N'Cyclopropyl-N-(fluorophenyl)-N-hydroxyureas
|
JPS5929199B2
(ja)
|
1980-08-25 |
1984-07-18 |
一丸フアルコス株式会社 |
脂溶性シルクペプタイドの製造法
|
US4314380A
(en)
*
|
1980-09-26 |
1982-02-09 |
Koken Co., Ltd. |
Artificial bone
|
US4367239A
(en)
|
1980-09-29 |
1983-01-04 |
Kefalas A/S |
Nitrosourea derivatives, pharmaceutical compositions thereof and method of preparation
|
US4301277A
(en)
|
1980-10-20 |
1981-11-17 |
Sri International |
3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
|
JPS5775993A
(en)
|
1980-10-30 |
1982-05-12 |
Tetsuo Suami |
Novel nitrosourea derivative and its preparation
|
JPS6041078B2
(ja)
|
1980-11-05 |
1985-09-13 |
日新製糖株式会社 |
ゲンチアノ−スニトロソ尿素誘導体
|
US4415665A
(en)
|
1980-12-12 |
1983-11-15 |
Pharmacia Fine Chemicals Ab |
Method of covalently binding biologically active organic substances to polymeric substances
|
US4314054A
(en)
|
1981-03-23 |
1982-02-02 |
Sri International |
3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin
|
US4494547A
(en)
|
1981-03-30 |
1985-01-22 |
North Carolina Central University |
2H-isoindolediones, their synthesis and use as radiosensitizers
|
US4414147A
(en)
|
1981-04-17 |
1983-11-08 |
Massachusetts Institute Of Technology |
Methods of decreasing the hydrophobicity of fibroblast and other interferons
|
US4375432A
(en)
|
1981-05-12 |
1983-03-01 |
Eli Lilly And Company |
Method of preparing vincristine
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
US4451568A
(en)
*
|
1981-07-13 |
1984-05-29 |
Battelle Memorial Institute |
Composition for binding bioactive substances
|
US4357274A
(en)
|
1981-08-06 |
1982-11-02 |
Intermedicat Gmbh |
Process for the manufacture of sclero protein transplants with increased biological stability
|
US4415628A
(en)
|
1981-10-26 |
1983-11-15 |
Seton Company |
Moisture vapor permeable sheet materials
|
JPS5896026A
(ja)
*
|
1981-10-30 |
1983-06-07 |
Nippon Chemiphar Co Ltd |
新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
|
US4424208A
(en)
*
|
1982-01-11 |
1984-01-03 |
Collagen Corporation |
Collagen implant material and method for augmenting soft tissue
|
US4462992A
(en)
|
1982-02-08 |
1984-07-31 |
Research Corporation |
Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
|
US4582640A
(en)
*
|
1982-03-08 |
1986-04-15 |
Collagen Corporation |
Injectable cross-linked collagen implant material
|
US4578067A
(en)
*
|
1982-04-12 |
1986-03-25 |
Alcon (Puerto Rico) Inc. |
Hemostatic-adhesive, collagen dressing for severed biological surfaces
|
JPS58180162A
(ja)
|
1982-04-19 |
1983-10-21 |
株式会社高研 |
抗血栓性医用材料
|
US4544516A
(en)
*
|
1982-07-28 |
1985-10-01 |
Battelle Development Corporation |
Collagen orientation
|
US4737544A
(en)
*
|
1982-08-12 |
1988-04-12 |
Biospecific Technologies, Inc. |
Biospecific polymers
|
US4973493A
(en)
|
1982-09-29 |
1990-11-27 |
Bio-Metric Systems, Inc. |
Method of improving the biocompatibility of solid surfaces
|
US4585859A
(en)
|
1983-05-24 |
1986-04-29 |
Sri International |
Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
|
JPS59219300A
(ja)
|
1983-05-27 |
1984-12-10 |
Nisshin Seito Kk |
シヨ糖ニトロソ尿素誘導体
|
JPS6028936A
(ja)
*
|
1983-07-27 |
1985-02-14 |
Koken:Kk |
アテロコラ−ゲン水溶液およびその製造方法
|
US4563351A
(en)
*
|
1983-08-01 |
1986-01-07 |
Forsyth Dental Infirmary For Children |
Self-gelling therapeutic compositions for topical application
|
US4902791A
(en)
|
1983-08-30 |
1990-02-20 |
Sanofi S.A. |
Nitrosourea derivatives, process for their preparation and medicaments containing them
|
US4490529A
(en)
|
1983-09-06 |
1984-12-25 |
Dana-Farber Cancer Institute, Inc. |
Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
|
US4894364A
(en)
|
1983-10-26 |
1990-01-16 |
Greer Sheldon B |
Method and materials for sensitizing neoplastic tissue to radiation
|
US4515637A
(en)
*
|
1983-11-16 |
1985-05-07 |
Seton Company |
Collagen-thrombin compositions
|
US4496689A
(en)
*
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
US4894366A
(en)
|
1984-12-03 |
1990-01-16 |
Fujisawa Pharmaceutical Company, Ltd. |
Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
|
CA1295796C
(en)
*
|
1984-03-27 |
1992-02-18 |
Conrad Whyne |
Biodegradable matrix and methods for producing same
|
JPS6110511A
(ja)
|
1984-06-26 |
1986-01-18 |
Sumitomo Chem Co Ltd |
低酸素細胞放射線増感剤
|
US4789663A
(en)
|
1984-07-06 |
1988-12-06 |
Collagen Corporation |
Methods of bone repair using collagen
|
US4681091A
(en)
|
1984-08-03 |
1987-07-21 |
Picker Donald H |
Combination modality cancer therapy
|
JPS6145765A
(ja)
*
|
1984-08-07 |
1986-03-05 |
宇部興産株式会社 |
血管補綴物及びその製造方法
|
US4553974A
(en)
|
1984-08-14 |
1985-11-19 |
Mayo Foundation |
Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
|
US4687820A
(en)
*
|
1984-08-22 |
1987-08-18 |
Cuno Incorporated |
Modified polypeptide supports
|
US4557764A
(en)
|
1984-09-05 |
1985-12-10 |
Collagen Corporation |
Process for preparing malleable collagen and the product thereof
|
US4563350A
(en)
*
|
1984-10-24 |
1986-01-07 |
Collagen Corporation |
Inductive collagen based bone repair preparations
|
US4588831A
(en)
|
1984-11-09 |
1986-05-13 |
Natec |
Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-naphthoquinone, and process for their production and use
|
GB8430252D0
(en)
*
|
1984-11-30 |
1985-01-09 |
Beecham Group Plc |
Compounds
|
US4600533A
(en)
*
|
1984-12-24 |
1986-07-15 |
Collagen Corporation |
Collagen membranes for medical use
|
SU1261253A1
(ru)
|
1984-12-27 |
1990-10-07 |
Отделение Института химической физики АН СССР |
Оксоаммониевые производные нитрозомочевины, про вл ющие противоопухолевую активность, и способ их получени
|
US4732863A
(en)
*
|
1984-12-31 |
1988-03-22 |
University Of New Mexico |
PEG-modified antibody with reduced affinity for cell surface Fc receptors
|
JPS61167616A
(ja)
|
1985-01-22 |
1986-07-29 |
Adeka Argus Chem Co Ltd |
放射線増感剤
|
US4841045A
(en)
|
1985-03-12 |
1989-06-20 |
University Of Vermont & State Agricultural College |
Synthesis of vinblastine and vincristine type compounds
|
US4642117A
(en)
*
|
1985-03-22 |
1987-02-10 |
Collagen Corporation |
Mechanically sheared collagen implant material and method
|
CA1260391A
(en)
*
|
1985-03-28 |
1989-09-26 |
Karl A. Piez |
Xenogeneic collagen/mineral preparations in bone repair
|
US5032617A
(en)
|
1985-05-03 |
1991-07-16 |
Sri International |
Substituted benzamide radiosensitizers
|
US5215738A
(en)
|
1985-05-03 |
1993-06-01 |
Sri International |
Benzamide and nicotinamide radiosensitizers
|
FR2582651B1
(fr)
|
1985-06-03 |
1987-08-28 |
Pf Medicament |
Procede de preparation de vincristine
|
DE3521684A1
(de)
*
|
1985-06-18 |
1986-12-18 |
Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg |
Verfahren zur beschichtung von polymeren
|
EP0206448B1
(de)
*
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
|
US4766106A
(en)
*
|
1985-06-26 |
1988-08-23 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using polymer conjugation
|
JPS6230768A
(ja)
|
1985-08-01 |
1987-02-09 |
Taisho Pharmaceut Co Ltd |
イミダゾ−ル誘導体
|
JPS6230777A
(ja)
|
1985-08-01 |
1987-02-09 |
Taisho Pharmaceut Co Ltd |
イミダゾ−ル誘導体
|
JPH0720864B2
(ja)
|
1985-08-15 |
1995-03-08 |
旭電化工業株式会社 |
放射線増感剤
|
JPH0723308B2
(ja)
|
1985-12-12 |
1995-03-15 |
旭電化工業株式会社 |
放射線増感剤
|
US4851513A
(en)
*
|
1985-09-06 |
1989-07-25 |
Minnesota Mining And Manufacturing Company |
Viscoelastic collagen solution for opthalmic use and method of preparation
|
SU1336489A1
(ru)
|
1985-10-24 |
1990-02-15 |
Отделение Института химической физики АН СССР |
Способ получени нитроксильных производных нитрозомочевины общей формулы
|
JPH0717518B2
(ja)
|
1985-11-28 |
1995-03-01 |
湧永製薬株式会社 |
制ガン作用調節剤
|
EP0232693A3
(de)
|
1985-12-16 |
1988-04-06 |
La Region Wallonne |
Konjugate des Vinblastins und seiner Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
|
JPS63502354A
(ja)
|
1986-01-06 |
1988-09-08 |
ザ ユニヴァーシティ オブ メルボルン |
コラ−ゲン生産物
|
US4774227A
(en)
*
|
1986-02-14 |
1988-09-27 |
Collagen Corporation |
Collagen compositions for bone repair containing autogeneic marrow
|
US4983580A
(en)
*
|
1986-04-04 |
1991-01-08 |
Allergan, Inc. |
Methods and materials for use in corneal wound healing
|
US4745180A
(en)
*
|
1986-06-27 |
1988-05-17 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using heparin fragments
|
US4841085A
(en)
|
1986-06-30 |
1989-06-20 |
Board Of Regents, University Of Texas System |
Aldophosphamides
|
US6432919B1
(en)
|
1986-07-01 |
2002-08-13 |
Genetics Institute, Inc. |
Bone morphogenetic protein-3 and compositions
|
US4877864A
(en)
|
1987-03-26 |
1989-10-31 |
Genetics Institute, Inc. |
Osteoinductive factors
|
US5013649A
(en)
|
1986-07-01 |
1991-05-07 |
Genetics Institute, Inc. |
DNA sequences encoding osteoinductive products
|
FR2601675B1
(fr)
|
1986-07-17 |
1988-09-23 |
Rhone Poulenc Sante |
Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
|
FR2601676B1
(fr)
|
1986-07-17 |
1988-09-23 |
Rhone Poulenc Sante |
Procede de preparation du taxol et du desacetyl-10 taxol
|
US5004606A
(en)
|
1986-09-24 |
1991-04-02 |
Hybritech Incorporated |
Non-covalent antibody-anthracycline immunocomplexes
|
US5175287A
(en)
|
1986-09-25 |
1992-12-29 |
S R I International |
Process for preparing 1,2,4-benzotriazine oxides
|
US5624925A
(en)
|
1986-09-25 |
1997-04-29 |
Sri International |
1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
|
US4979959A
(en)
|
1986-10-17 |
1990-12-25 |
Bio-Metric Systems, Inc. |
Biocompatible coating for solid surfaces
|
JPS63170375A
(ja)
|
1987-01-07 |
1988-07-14 |
Pola Chem Ind Inc |
ヘテロ環化合物誘導体、その製造法およびこれを有効成分とする放射線増感剤
|
GB8701381D0
(en)
|
1987-01-22 |
1987-02-25 |
Erba Farmitalia |
Antitumor agent
|
US5047528A
(en)
|
1987-01-22 |
1991-09-10 |
University Of Bristish Columbia |
Process of synthesis of vinblastine and vincristine
|
FR2611203B1
(fr)
|
1987-02-20 |
1989-06-09 |
Sturtz Georges |
Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
|
US5034320A
(en)
|
1987-03-31 |
1991-07-23 |
Allelix, Inc. |
Vinblastine synthesis
|
US4921963A
(en)
|
1987-04-13 |
1990-05-01 |
British Columbia Cancer Foundation |
Platinum complexes with one radiosensitizing ligand
|
EP0290280B1
(de)
|
1987-05-08 |
1994-01-19 |
Sankyo Company Limited |
Antitumor-Platinkomplexe, deren Herstellung und deren therapeutische Verwendung
|
JPS63310873A
(ja)
|
1987-06-09 |
1988-12-19 |
Taiho Yakuhin Kogyo Kk |
4,5−ジニトロイミダゾ−ル誘導体
|
CA1329206C
(en)
|
1987-06-10 |
1994-05-03 |
Tsutomu Kagiya |
Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
|
JP2602887B2
(ja)
|
1987-06-10 |
1997-04-23 |
京都大学長 |
新規含フッ素3−ニトロ−1,2,4−トリアゾールおよびそれを含む放射線増感剤
|
US5304654A
(en)
|
1987-06-10 |
1994-04-19 |
Yasunori Nishijima |
Fluorine-containing nitroimidazole compounds
|
US4797397A
(en)
|
1987-07-31 |
1989-01-10 |
Warner-Lambert Company |
2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
|
US5532220A
(en)
|
1987-08-31 |
1996-07-02 |
The Regents Of The University Of California |
Genetic mechanisms of tumor suppression
|
JPH01139596A
(ja)
|
1987-11-25 |
1989-06-01 |
Pola Chem Ind Inc |
ヘテロ環化合物誘導体、その製造法並びにこれを有効成分とする放射線増感剤、抗ウイルス剤及び抗癌剤
|
US5364622A
(en)
|
1987-12-04 |
1994-11-15 |
Dr. Karl Thomae Gmbh |
Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel
|
US4996152A
(en)
|
1987-12-04 |
1991-02-26 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Avian herpesvirus amplicon as a eucaryotic expression vector
|
US4950699A
(en)
*
|
1988-01-11 |
1990-08-21 |
Genetic Laboratories, Inc. |
Wound dressing incorporating collagen in adhesive layer
|
US4847325A
(en)
*
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
US5192316A
(en)
*
|
1988-02-16 |
1993-03-09 |
Allergan, Inc. |
Ocular device
|
US5024742A
(en)
*
|
1988-02-24 |
1991-06-18 |
Cedars-Sinai Medical Center |
Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
|
US4942184A
(en)
|
1988-03-07 |
1990-07-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
Water soluble, antineoplastic derivatives of taxol
|
US6133029A
(en)
|
1988-03-21 |
2000-10-17 |
Chiron Corporation |
Replication defective viral vectors for infecting human cells
|
US5716826A
(en)
|
1988-03-21 |
1998-02-10 |
Chiron Viagene, Inc. |
Recombinant retroviruses
|
US5591624A
(en)
|
1988-03-21 |
1997-01-07 |
Chiron Viagene, Inc. |
Retroviral packaging cell lines
|
US4923876A
(en)
|
1988-04-18 |
1990-05-08 |
Cetus Corporation |
Vinca alkaloid pharmaceutical compositions
|
US5290552A
(en)
*
|
1988-05-02 |
1994-03-01 |
Matrix Pharmaceutical, Inc./Project Hear |
Surgical adhesive material
|
US4908356A
(en)
|
1988-05-25 |
1990-03-13 |
Research Corporation Technologies, Inc. |
Aldophosphamide derivatives useful as antitumor agents
|
US5190929A
(en)
|
1988-05-25 |
1993-03-02 |
Research Corporation Technologies, Inc. |
Cyclophosphamide analogs useful as anti-tumor agents
|
US4950483A
(en)
*
|
1988-06-30 |
1990-08-21 |
Collagen Corporation |
Collagen wound healing matrices and process for their production
|
US5167960A
(en)
|
1988-08-03 |
1992-12-01 |
New England Deaconess Hospital Corporation |
Hirudin-coated biocompatible substance
|
US4906460A
(en)
|
1988-08-05 |
1990-03-06 |
Sorenco |
Additive for hair treatment compositions
|
US5665583A
(en)
|
1988-08-12 |
1997-09-09 |
Arch Dev Corp |
Methods and materials relating to IMPDH and GMP production
|
US5066658A
(en)
|
1988-11-10 |
1991-11-19 |
Ortho Pharmaceutical Corporation |
Substituted hydroxyureas
|
US5304595A
(en)
|
1988-11-21 |
1994-04-19 |
Collagen Corporation |
Collagen-polymer conjugates
|
US5475052A
(en)
|
1988-11-21 |
1995-12-12 |
Collagen Corporation |
Collagen-synthetic polymer matrices prepared using a multiple step reaction
|
US5264214A
(en)
|
1988-11-21 |
1993-11-23 |
Collagen Corporation |
Composition for bone repair
|
US5936035A
(en)
*
|
1988-11-21 |
1999-08-10 |
Cohesion Technologies, Inc. |
Biocompatible adhesive compositions
|
US5614587A
(en)
*
|
1988-11-21 |
1997-03-25 |
Collagen Corporation |
Collagen-based bioadhesive compositions
|
US5162430A
(en)
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
US5109112A
(en)
|
1989-01-19 |
1992-04-28 |
Merck & Co., Inc. |
FK-506 cytosolic binding protein
|
EP0448650A4
(en)
|
1989-02-01 |
1992-05-13 |
The General Hospital Corporation |
Herpes simplex virus type i expression vector
|
US5457183A
(en)
|
1989-03-06 |
1995-10-10 |
Board Of Regents, The University Of Texas System |
Hydroxylated texaphyrins
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
WO1990011287A1
(en)
|
1989-03-21 |
1990-10-04 |
The United States Of America, Represented By The Secretary, United States Department Of Commerce |
Matrix metalloproteinase inhibitor peptides
|
US5641764A
(en)
|
1989-03-31 |
1997-06-24 |
Peter Maccallum Institute |
Halogenated DNA ligand radiosensitizers for cancer therapy
|
JPH04193900A
(ja)
|
1989-03-31 |
1992-07-13 |
Res Dev Found |
網膜芽腫遺伝子産物の抗体とその利用
|
US5122614A
(en)
*
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5324844A
(en)
*
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5141747A
(en)
*
|
1989-05-23 |
1992-08-25 |
Minnesota Mining And Manufacturing Company |
Denatured collagen membrane
|
US5200411A
(en)
|
1989-06-14 |
1993-04-06 |
Sandoz, Ltd. |
Heteroatoms-containing tricyclic compounds
|
DE3924424A1
(de)
|
1989-07-24 |
1991-01-31 |
Boehringer Mannheim Gmbh |
Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
|
US5100885A
(en)
|
1989-08-01 |
1992-03-31 |
Johnson Matthey, Inc. |
Copper radiosensitizers
|
NZ234718A
(en)
*
|
1989-08-11 |
1992-05-26 |
Saint Gobain Isover |
Decomposable glass fibres
|
US5166149A
(en)
|
1989-09-08 |
1992-11-24 |
Chemex Pharmaceuticals, Inc. |
Methotrexate compositions and methods of treatment using same
|
DE69028610T2
(de)
|
1989-12-19 |
1997-02-06 |
Pharmacia Spa |
Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte
|
KR927003539A
(ko)
|
1990-01-26 |
1992-12-18 |
스즈끼 쯔네시 |
2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
|
US5201764A
(en)
*
|
1990-02-28 |
1993-04-13 |
Autogenesis Technologies, Inc. |
Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
|
US5104957A
(en)
|
1990-02-28 |
1992-04-14 |
Autogenesis Technologies, Inc. |
Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
|
US5989894A
(en)
|
1990-04-20 |
1999-11-23 |
University Of Wyoming |
Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA
|
US5219564A
(en)
*
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
US5688678A
(en)
|
1990-05-16 |
1997-11-18 |
Genetics Institute, Inc. |
DNA encoding and methods for producing BMP-8 proteins
|
US5594158A
(en)
|
1990-06-22 |
1997-01-14 |
The Board Of Regents Of The University Of Nebraska |
Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin
|
US5210030A
(en)
|
1990-06-25 |
1993-05-11 |
Merck & Co., Inc. |
Process for selectively acylating immunomycin
|
AU8284991A
(en)
|
1990-06-29 |
1992-01-23 |
Regents Of The University Of Michigan, The |
Neurofibromatosis gene
|
US5147652A
(en)
|
1990-07-03 |
1992-09-15 |
Cell Research Corporation |
Autobiotics and their use in eliminating nonself cells in vivo
|
US5209776A
(en)
*
|
1990-07-27 |
1993-05-11 |
The Trustees Of Columbia University In The City Of New York |
Tissue bonding and sealing composition and method of using the same
|
US5059699A
(en)
|
1990-08-28 |
1991-10-22 |
Virginia Tech Intellectual Properties, Inc. |
Water soluble derivatives of taxol
|
US5278324A
(en)
|
1990-08-28 |
1994-01-11 |
Virginia Tech Intellectual Properties, Inc. |
Water soluble derivatives of taxol
|
SE466754B
(sv)
*
|
1990-09-13 |
1992-03-30 |
Berol Nobel Ab |
Saett att kovalent binda biopolymerer till hydrofila ytor
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
US5817491A
(en)
|
1990-09-21 |
1998-10-06 |
The Regents Of The University Of California |
VSV G pseusdotyped retroviral vectors
|
US5198421A
(en)
|
1991-04-26 |
1993-03-30 |
Merck & Co., Inc. |
Phosphorylated cyclic lipopeptide
|
US5410016A
(en)
*
|
1990-10-15 |
1995-04-25 |
Board Of Regents, The University Of Texas System |
Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
|
US5380536A
(en)
|
1990-10-15 |
1995-01-10 |
The Board Of Regents, The University Of Texas System |
Biocompatible microcapsules
|
US5626863A
(en)
*
|
1992-02-28 |
1997-05-06 |
Board Of Regents, The University Of Texas System |
Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
|
US5169754A
(en)
|
1990-10-31 |
1992-12-08 |
Coulter Corporation |
Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same
|
US5189178A
(en)
|
1990-11-21 |
1993-02-23 |
Galardy Richard E |
Matrix metalloprotease inhibitors
|
US5239078A
(en)
|
1990-11-21 |
1993-08-24 |
Glycomed Incorporated |
Matrix metalloprotease inhibitors
|
US5183900A
(en)
|
1990-11-21 |
1993-02-02 |
Galardy Richard E |
Matrix metalloprotease inhibitors
|
US5268384A
(en)
|
1990-11-21 |
1993-12-07 |
Galardy Richard E |
Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
|
US5892112A
(en)
|
1990-11-21 |
1999-04-06 |
Glycomed Incorporated |
Process for preparing synthetic matrix metalloprotease inhibitors
|
WO1993013663A1
(en)
|
1992-01-17 |
1993-07-22 |
Abbott Laboratories |
Method of directing biosynthesis of specific polyketides
|
US5116756A
(en)
|
1991-01-28 |
1992-05-26 |
Merck & Co., Inc. |
Process for producing FK-506
|
US5219895A
(en)
*
|
1991-01-29 |
1993-06-15 |
Autogenesis Technologies, Inc. |
Collagen-based adhesives and sealants and methods of preparation and use thereof
|
US5294715A
(en)
|
1991-02-01 |
1994-03-15 |
University Of Pittsburgh |
Acridine-intercalator based hypoxia selective cytotoxins
|
US5156613A
(en)
*
|
1991-02-13 |
1992-10-20 |
Interface Biomedical Laboratories Corp. |
Collagen welding rod material for use in tissue welding
|
GB9103430D0
(en)
|
1991-02-19 |
1991-04-03 |
Smithkline Beecham Plc |
Novel compound
|
TW197439B
(de)
|
1991-04-04 |
1993-01-01 |
Ueno Pharmaceutics Applic Res Co Ltd |
|
US5147877A
(en)
|
1991-04-18 |
1992-09-15 |
Merck & Co. Inc. |
Semi-synthetic immunosuppressive macrolides
|
US5093338A
(en)
|
1991-04-23 |
1992-03-03 |
Merck & Co., Inc. |
Lipophilic macrolide useful as an immunosuppressant
|
US5091389A
(en)
|
1991-04-23 |
1992-02-25 |
Merck & Co., Inc. |
Lipophilic macrolide useful as an immunosuppressant
|
US5140018A
(en)
|
1991-05-07 |
1992-08-18 |
Abbott Laboratories |
1,3,2-benzodithiazole-1-oxide compounds
|
US5889169A
(en)
|
1991-05-16 |
1999-03-30 |
Cold Spring Harbor Laboratory |
Cell cycle regulatory protein p16 gene
|
US5225403A
(en)
|
1991-06-25 |
1993-07-06 |
Merck & Co., Inc. |
C-21 hydroxylated FK-506 antagonist
|
ATE175441T1
(de)
|
1991-06-25 |
1999-01-15 |
Genetics Inst |
Bmp-9 zusammensetzungen
|
CA2071160A1
(en)
|
1991-07-31 |
1993-02-01 |
Vittorio Farina |
Asymmetric synthesis of taxol side chain
|
US5256657A
(en)
|
1991-08-19 |
1993-10-26 |
Sterling Winthrop, Inc. |
Succinamide derivative matrix-metalloprotease inhibitors
|
US5563172A
(en)
|
1991-09-05 |
1996-10-08 |
Abbott Laboratories |
Macrocyclic amide and urea immunomodulators
|
US5561137A
(en)
|
1991-09-05 |
1996-10-01 |
Abbott Laboratories |
Thio-heterocyclic macrolactam immunomodulators
|
WO1993004679A1
(en)
|
1991-09-05 |
1993-03-18 |
Abbott Laboratories |
Macrocyclic immunomodulators
|
US5541193A
(en)
|
1991-09-05 |
1996-07-30 |
Abbott Laboratories |
Heterocycle-containing macrocyclic immunomodulators
|
US5604234A
(en)
|
1991-09-05 |
1997-02-18 |
Abbott Laboratories |
Substituted thiol macrolactam immunomodulators
|
US5534632A
(en)
|
1991-09-05 |
1996-07-09 |
Abbott Laboratories |
Macrocyclic carbamate immunomodulators
|
US5252732A
(en)
|
1991-09-09 |
1993-10-12 |
Merck & Co., Inc. |
D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
|
US5247076A
(en)
|
1991-09-09 |
1993-09-21 |
Merck & Co., Inc. |
Imidazolidyl macrolides having immunosuppressive activity
|
US5208241A
(en)
|
1991-09-09 |
1993-05-04 |
Merck & Co., Inc. |
N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
|
US5283253A
(en)
|
1991-09-23 |
1994-02-01 |
Florida State University |
Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
|
US5350866A
(en)
|
1991-09-23 |
1994-09-27 |
Bristol-Myers Squibb Company |
10-desacetoxytaxol derivatives
|
US5837747A
(en)
|
1991-10-29 |
1998-11-17 |
Vivorx, Inc. |
Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
|
FR2683529B1
(fr)
|
1991-11-12 |
1994-02-04 |
Bretagne Occidentale Universite |
Composes pharmaceutiques gem-diphosphonates analogues du cis-platine.
|
US5164399A
(en)
|
1991-11-18 |
1992-11-17 |
American Home Products Corporation |
Rapamycin pyrazoles
|
WO1993010076A1
(en)
|
1991-11-22 |
1993-05-27 |
The University Of Mississippi |
Synthesis and optical resolution of the taxol side chain and related compounds
|
NZ240785A
(en)
|
1991-11-28 |
1995-08-28 |
Cancer Res Campaign Tech |
Substituted nitro aniline derivatives and medicaments
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
US5221625A
(en)
|
1992-01-10 |
1993-06-22 |
Merck & Co., Inc. |
Cyclcic FR-900520 microbial biotransformation agent
|
US5272171A
(en)
|
1992-02-13 |
1993-12-21 |
Bristol-Myers Squibb Company |
Phosphonooxy and carbonate derivatives of taxol
|
MX9301188A
(es)
|
1992-03-05 |
1994-07-29 |
American Home Prod |
Nuevos sulfonatos y 42-(n-carboalcoxi)sulfamatos en posicion 42 de la rapamicina, procedimiento para su preparacion y composicion farmaceutica que los comprende.
|
US5200534A
(en)
|
1992-03-13 |
1993-04-06 |
University Of Florida |
Process for the preparation of taxol and 10-deacetyltaxol
|
US5324634A
(en)
|
1992-03-31 |
1994-06-28 |
The Research Foundation Of State University Of New York |
Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
|
US5440056A
(en)
|
1992-04-17 |
1995-08-08 |
Abbott Laboratories |
9-deoxotaxane compounds
|
WO1993021942A2
(en)
|
1992-05-01 |
1993-11-11 |
British Biotech Pharmaceuticals Limited |
Use of mmp inhibitors
|
CA2136213A1
(en)
|
1992-05-21 |
1993-11-25 |
Richard N. Arteca |
Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
WO1993024476A1
(en)
|
1992-06-04 |
1993-12-09 |
Clover Consolidated, Limited |
Water-soluble polymeric carriers for drug delivery
|
WO1993025533A1
(en)
|
1992-06-05 |
1993-12-23 |
Abbott Laboratories |
Methods and reagents for the determination of immunosuppressive agents
|
US5248796A
(en)
|
1992-06-18 |
1993-09-28 |
Bristol-Myers Squibb Company |
Taxol derivatives
|
GB9213077D0
(en)
|
1992-06-19 |
1992-08-05 |
Erba Carlo Spa |
Polymerbound taxol derivatives
|
US5274137A
(en)
|
1992-06-23 |
1993-12-28 |
Nicolaou K C |
Intermediates for preparation of taxols
|
US5254580A
(en)
|
1993-01-19 |
1993-10-19 |
Bristol-Myers Squibb Company |
7,8-cyclopropataxanes
|
US5294637A
(en)
|
1992-07-01 |
1994-03-15 |
Bristol-Myers Squibb Company |
Fluoro taxols
|
AU677789B2
(en)
|
1992-07-02 |
1997-05-08 |
Collagen Corporation |
Biocompatible polymer conjugates
|
US5385606A
(en)
|
1992-07-06 |
1995-01-31 |
Kowanko; Nicholas |
Adhesive composition and method
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
ZA935110B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
GB9215665D0
(en)
|
1992-07-23 |
1992-09-09 |
British Bio Technology |
Compounds
|
US5324644A
(en)
|
1992-07-28 |
1994-06-28 |
Merck & Co., Inc. |
Process for producing immunosuppressant agent
|
MX9304399A
(es)
|
1992-07-31 |
1994-02-28 |
Warner Lambert Co |
Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
|
US5514379A
(en)
*
|
1992-08-07 |
1996-05-07 |
The General Hospital Corporation |
Hydrogel compositions and methods of use
|
MX9304868A
(es)
|
1992-08-13 |
1994-05-31 |
American Home Prod |
27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene.
|
US5202448A
(en)
|
1992-08-14 |
1993-04-13 |
Napro Biotherapeutics, Inc. |
Processes of converting taxanes into baccatin III
|
US5614549A
(en)
*
|
1992-08-21 |
1997-03-25 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
WO1994005282A1
(en)
|
1992-09-04 |
1994-03-17 |
The Scripps Research Institute |
Water soluble taxol derivatives
|
CA2100808A1
(en)
|
1992-10-01 |
1994-04-02 |
Vittorio Farina |
Deoxy paclitaxels
|
US5318895A
(en)
|
1992-10-05 |
1994-06-07 |
Merck & Co., Inc. |
Aspergillus niger mutants
|
FR2696464B1
(fr)
|
1992-10-05 |
1994-11-10 |
Rhone Poulenc Rorer Sa |
Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
|
FR2696463B1
(fr)
|
1992-10-05 |
1994-11-25 |
Rhone Poulenc Rorer Sa |
Procédé d'obtention de la désacétyl-10 baccatine III.
|
FR2696461B1
(fr)
|
1992-10-05 |
1994-11-10 |
Rhone Poulenc Rorer Sa |
Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
|
FR2696462B1
(fr)
|
1992-10-05 |
1994-11-25 |
Rhone Poulenc Rorer Sa |
Procédé d'obtention de la désacétyl-10 baccatine III.
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
US5411984A
(en)
|
1992-10-16 |
1995-05-02 |
Virginia Tech Intellectual Properties, Inc. |
Water soluble analogs and prodrugs of taxol
|
US5552156A
(en)
|
1992-10-23 |
1996-09-03 |
Ohio State University |
Liposomal and micellular stabilization of camptothecin drugs
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
ZA938349B
(en)
|
1992-11-10 |
1994-08-01 |
Smithkline Beecham Corp |
Rapamycin derivatives.
|
US5858679A
(en)
|
1992-11-12 |
1999-01-12 |
Fornace, Jr.; Albert J. |
Method for determining the presence of functional p53 by measuring GADD45 protein expression
|
GB9223904D0
(en)
|
1992-11-13 |
1993-01-06 |
British Bio Technology |
Inhibition of cytokine production
|
US5661033A
(en)
|
1992-11-25 |
1997-08-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Gene transfer using herpes virus vectors as a tool for neuroprotection
|
US5380751A
(en)
|
1992-12-04 |
1995-01-10 |
Bristol-Myers Squibb Company |
6,7-modified paclitaxels
|
US5279949A
(en)
|
1992-12-07 |
1994-01-18 |
Board Of Trustees Operating Michigan State University |
Process for the isolation and purification of taxol and taxanes from Taxus spp
|
US5298643A
(en)
*
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
JPH06203767A
(ja)
|
1992-12-28 |
1994-07-22 |
Matsushita Electron Corp |
偏向ヨーク
|
US5349001A
(en)
*
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
GB9302016D0
(en)
|
1993-02-02 |
1993-03-17 |
Sandoz Ltd |
Compounds
|
US5321095A
(en)
*
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
US6284513B1
(en)
|
1993-02-03 |
2001-09-04 |
Warner-Lambert Company |
Process for the production of stromelysin catalytic domain protein
|
GB9302569D0
(en)
|
1993-02-10 |
1993-03-24 |
Smithkline Beecham Plc |
Novel compound
|
US5310903A
(en)
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
Imidazolidyl rapamycin derivatives
|
US5310901A
(en)
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
|
WO1994020089A1
(en)
|
1993-03-09 |
1994-09-15 |
Enzon, Inc. |
Taxol-based compositions with enhanced bioactivity
|
US5457194A
(en)
|
1993-03-17 |
1995-10-10 |
Abbott Laboratories |
Substituted aliphatic amine-containing macrocyclic immunomodulators
|
WO1994021253A1
(en)
|
1993-03-17 |
1994-09-29 |
Abbott Laboratories |
Substituted aliphatic amine-containing macrocyclic immunomodulators
|
US5594006A
(en)
|
1993-03-18 |
1997-01-14 |
Otsuka Pharmaceutical Co., Ltd. |
Carbostyril derivatives as matrix metalloproteinases inhibitors
|
US5382582A
(en)
|
1993-03-26 |
1995-01-17 |
Chan; Carcy L. |
Methotrexate analogs and methods of using same
|
GB9307956D0
(en)
|
1993-04-17 |
1993-06-02 |
Walls Alan J |
Hydroxamic acid derivatives
|
DE69435044T2
(de)
|
1993-04-23 |
2008-09-18 |
Wyeth |
Rapamycin - Konjugate und Antikörper
|
US5412092A
(en)
|
1993-04-23 |
1995-05-02 |
Bristol-Myers Squibb Company |
N-substituted 2-azetidinones
|
US5306727A
(en)
|
1993-04-30 |
1994-04-26 |
Research Corporation Technologies, Inc. |
Phosphoramidates useful as antitumor agents
|
US5380897A
(en)
|
1993-05-25 |
1995-01-10 |
Hoeschele; James D. |
Tri(platinum) complexes
|
FR2705686B1
(fr)
|
1993-05-28 |
1995-08-18 |
Transgene Sa |
Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
|
US5549904A
(en)
*
|
1993-06-03 |
1996-08-27 |
Orthogene, Inc. |
Biological adhesive composition and method of promoting adhesion between tissue surfaces
|
DE69434447T2
(de)
|
1993-06-07 |
2006-05-18 |
Vical, Inc., San Diego |
Für die gentherapie verwendbare plasmide
|
DE69433299T2
(de)
|
1993-06-15 |
2004-09-09 |
E.I. Du Pont De Nemours And Co., Wilmington |
Rekombinante spinnerseide analoge
|
JPH07107058B2
(ja)
|
1993-06-22 |
1995-11-15 |
旭電化工業株式会社 |
ニトロトリアゾール化合物
|
US6140087A
(en)
|
1993-06-24 |
2000-10-31 |
Advec, Inc. |
Adenovirus vectors for gene therapy
|
US6080569A
(en)
|
1993-06-24 |
2000-06-27 |
Merck & Co., Inc. |
Adenovirus vectors generated from helper viruses and helper-dependent vectors
|
ES2139746T3
(es)
|
1993-07-20 |
2000-02-16 |
Pfizer |
Heteroaril cicloalquenil hidroxiureas.
|
GB9315914D0
(en)
|
1993-07-31 |
1993-09-15 |
Smithkline Beecham Plc |
Novel compound
|
US5773428A
(en)
|
1993-08-05 |
1998-06-30 |
Syntex (U.S.A.) Inc. |
Matrix metalloprotease inhibitors
|
US6013792A
(en)
|
1993-08-05 |
2000-01-11 |
Syntex (U.S.A.), Inc. |
Matrix metalloprotease inhibitors
|
US5387680A
(en)
|
1993-08-10 |
1995-02-07 |
American Home Products Corporation |
C-22 ring stabilized rapamycin derivatives
|
GB9318612D0
(en)
|
1993-09-08 |
1993-10-27 |
Sandoz Ltd |
An assay
|
US5409915A
(en)
|
1993-09-14 |
1995-04-25 |
The University Of Vermont And State Agricultural College |
Bis-platinum (IV) complexes as chemotherapeutic agents
|
US6015686A
(en)
|
1993-09-15 |
2000-01-18 |
Chiron Viagene, Inc. |
Eukaryotic layered vector initiation systems
|
US5455262A
(en)
|
1993-10-06 |
1995-10-03 |
Florida State University |
Mercaptosulfide metalloproteinase inhibitors
|
US5470834A
(en)
|
1993-10-06 |
1995-11-28 |
Florida State University |
Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
|
US5650442A
(en)
|
1993-10-08 |
1997-07-22 |
The United States Of America As Represented By The Department Of Health And Human Services |
Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
|
US6210939B1
(en)
|
1993-10-25 |
2001-04-03 |
Canji, Inc. |
Recombinant adenoviral vector and methods of use
|
US5605976A
(en)
*
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
US5643575A
(en)
*
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US6037472A
(en)
|
1993-11-04 |
2000-03-14 |
Syntex (U.S.A.) Inc. |
Matrix metalloprotease inhibitors
|
WO1995013375A1
(en)
|
1993-11-10 |
1995-05-18 |
The Johns Hopkins University |
Tumor suppressor waf1
|
GB9323165D0
(en)
|
1993-11-10 |
1994-01-05 |
Chiros Ltd |
Compounds
|
WO1995014023A1
(en)
|
1993-11-19 |
1995-05-26 |
Abbott Laboratories |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
US5527907A
(en)
|
1993-11-19 |
1996-06-18 |
Abbott Laboratories |
Macrolide immunomodulators
|
WO1995015328A1
(en)
|
1993-11-30 |
1995-06-08 |
Abbott Laboratories |
Macrocyclic immunomodulators with novel cyclohexyl ring replacements
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
EP0734389B1
(de)
|
1993-12-17 |
2000-03-29 |
Novartis AG |
Rapamycin-derivate als immunosuppressoren
|
GB9401129D0
(en)
|
1994-01-21 |
1994-03-16 |
British Bio Technology |
Hydroxamic acid derivatives as metalloproteinase inhibitors
|
CA2181709A1
(en)
|
1994-01-22 |
1995-07-27 |
Raymond Paul Beckett |
Hydroxamic acid derivatives as metalloproteinase inhibitors
|
US5457182A
(en)
|
1994-02-15 |
1995-10-10 |
Merck & Co., Inc. |
FK-506 cytosolic binding protein, FKBP12.6
|
US5444072A
(en)
|
1994-02-18 |
1995-08-22 |
Syntex (U.S.A.) Inc. |
6-substituted mycophenolic acid and derivatives
|
US5362735A
(en)
|
1994-02-23 |
1994-11-08 |
Smithkline Beecham Corporation |
Rapamycin derivatives
|
US5514716A
(en)
|
1994-02-25 |
1996-05-07 |
Sterling Winthrop, Inc. |
Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
|
FR2716893B1
(fr)
|
1994-03-03 |
1996-04-12 |
Rhone Poulenc Rorer Sa |
Virus recombinants, leur préparation et leur utilisation thérapeutique.
|
US5395850A
(en)
|
1994-03-10 |
1995-03-07 |
Bristol-Myers Squibb Company |
6,7-epoxy paclitaxels
|
GB9405076D0
(en)
|
1994-03-16 |
1994-04-27 |
Inst Of Ophtalmology |
A medical use of matrix metalloproteinase inhibitors
|
FI951367A
(fi)
|
1994-03-28 |
1995-09-29 |
Japan Energy Corp |
Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit)
|
EP0755454B1
(de)
|
1994-04-13 |
2008-02-13 |
The Rockefeller University |
Aav-vermittelte überbringung von dna in zellen des nervensystems
|
US6013517A
(en)
|
1994-05-09 |
2000-01-11 |
Chiron Corporation |
Crossless retroviral vectors
|
US6140099A
(en)
|
1994-05-20 |
2000-10-31 |
The Trustees Of The University Of Pennsylvania |
Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity
|
US5641636A
(en)
|
1994-05-20 |
1997-06-24 |
University Of Pennsylvania |
Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity
|
GB9411088D0
(en)
|
1994-06-03 |
1994-07-27 |
Hoffmann La Roche |
Hydroxylamine derivatives
|
EP1548118A2
(de)
|
1994-06-10 |
2005-06-29 |
Genvec, Inc. |
Komplementäre adenovirale Vektor-Systeme und Zelllinien
|
AU690703B2
(en)
|
1994-06-22 |
1998-04-30 |
British Biotech Pharmaceuticals Limited |
Metalloproteinase inhibitors
|
US5622866A
(en)
|
1994-06-23 |
1997-04-22 |
Merck & Co., Inc. |
Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
|
US5583114A
(en)
|
1994-07-27 |
1996-12-10 |
Minnesota Mining And Manufacturing Company |
Adhesive sealant composition
|
NZ291168A
(en)
|
1994-07-27 |
1998-06-26 |
Novartis Ag |
Cyclopeptolides which inhibit expression of adhesion molecules (icam-1, vcam and e-selectin)
|
GB9416897D0
(en)
|
1994-08-20 |
1994-10-12 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
CN1193978A
(zh)
|
1994-10-05 |
1998-09-23 |
奇罗斯恩有限公司 |
肽基化合物和它们作为金属蛋白酶抑制剂的医疗用途
|
EP0787200B1
(de)
|
1994-10-28 |
2005-04-20 |
The Trustees Of The University Of Pennsylvania |
Rekombinanter adenovirus und methoden zu dessen verwendung
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
US5789434A
(en)
|
1994-11-15 |
1998-08-04 |
Bayer Corporation |
Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
|
IL115995A0
(en)
|
1994-11-15 |
1996-01-31 |
Bayer Ag |
Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
|
EP0713707A1
(de)
|
1994-11-23 |
1996-05-29 |
Collagen Corporation |
Injizierbare, in Situ vernetzbare Kollagenszusammensetzung für die Weichgewebevermehrung
|
GB9423914D0
(en)
|
1994-11-26 |
1995-01-11 |
British Biotech Pharm |
Polyether derivatives as metalloproteinase inhibitors
|
US5532265A
(en)
|
1994-11-30 |
1996-07-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
|
US5639746A
(en)
|
1994-12-29 |
1997-06-17 |
The Procter & Gamble Company |
Hydroxamic acid-containing inhibitors of matrix metalloproteases
|
US5602142A
(en)
|
1994-12-21 |
1997-02-11 |
Evanston Hospital Corporation |
DNA-affinic hypoxia selective cytotoxins
|
JP2902318B2
(ja)
|
1994-12-28 |
1999-06-07 |
呉羽化学工業株式会社 |
エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤
|
US6033847A
(en)
|
1995-02-06 |
2000-03-07 |
St. Jude Children's Research Hospital |
InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof
|
US5672598A
(en)
|
1995-03-21 |
1997-09-30 |
The Procter & Gamble Company |
Lactam-containing hydroxamic acids
|
US5900245A
(en)
*
|
1996-03-22 |
1999-05-04 |
Focal, Inc. |
Compliant tissue sealants
|
WO1996029370A2
(en)
|
1995-03-23 |
1996-09-26 |
Focal, Inc. |
Redox and photoinitiator systems for priming for improved adherence of gels to substrates
|
EP0871755A1
(de)
|
1995-03-23 |
1998-10-21 |
Cantab Pharmaceuticals Research Limited |
Vektoren zur verabreichung von genen
|
US6025480A
(en)
|
1995-04-03 |
2000-02-15 |
Sloan-Kettering Institute For Cancer Research |
Isolated nucleic acid molecules encoding P57KIP2
|
US5691381A
(en)
|
1995-04-18 |
1997-11-25 |
The Dupont Merck Pharmaceutical Company |
Hydroxamic and carbocyclic acids as metalloprotease inhibitors
|
PT821671E
(pt)
|
1995-04-20 |
2001-04-30 |
Pfizer |
Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
|
EP0832875B1
(de)
|
1995-04-25 |
2004-06-30 |
Daiichi Fine Chemical Co., Ltd. |
In wasser hochlöslicher metalloproteinase-inhibitor
|
EP0826000B1
(de)
|
1995-05-10 |
2002-10-23 |
Darwin Discovery Limited |
Peptide, die metallproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
|
JPH11504934A
(ja)
|
1995-05-10 |
1999-05-11 |
カイロサイエンス・リミテッド |
金属プロテアーゼとtnfの放出を抑制するペプチジル化合物およびその治療的使用
|
WO1996035687A1
(en)
|
1995-05-10 |
1996-11-14 |
Chiroscience Limited |
Peptidyl compounds and their therapeutic use
|
JPH11505532A
(ja)
|
1995-05-10 |
1999-05-21 |
カイロサイエンス・リミテッド |
金属プロテアーゼとtnfの放出を抑制するペプチド化合物およびその治療的使用
|
GB9509631D0
(en)
|
1995-05-12 |
1995-07-05 |
Sandoz Ltd |
Antifungal combination
|
JP3133642B2
(ja)
|
1995-05-19 |
2001-02-13 |
花王株式会社 |
毛髪化粧料
|
US5627206A
(en)
|
1995-06-02 |
1997-05-06 |
Warner-Lambert Company |
Tricyclic inhibitor of matrix metalloproteinases
|
US5665764A
(en)
|
1995-06-02 |
1997-09-09 |
Warner-Lambert Company |
Tricyclic inhibitors of matrix metalloproteinases
|
US5886022A
(en)
|
1995-06-05 |
1999-03-23 |
Bayer Corporation |
Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
US5677282A
(en)
|
1995-06-07 |
1997-10-14 |
Proscript, Inc. |
Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
|
ES2187660T3
(es)
|
1995-06-09 |
2003-06-16 |
Novartis Ag |
Derivados de rapamicina.
|
DE69638058D1
(de)
|
1995-06-15 |
2009-11-26 |
Crucell Holland Bv |
Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie
|
US5917090A
(en)
|
1995-06-30 |
1999-06-29 |
British Biotech Pharmaceuticals Ltd. |
Matrix metalloproteinase inhibitors
|
GB9514867D0
(en)
|
1995-07-20 |
1995-09-20 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
KR980009238A
(ko)
|
1995-07-28 |
1998-04-30 |
우에노 도시오 |
설포닐아미노산 유도체
|
AUPN477695A0
(en)
|
1995-08-14 |
1995-09-07 |
Commonwealth Scientific And Industrial Research Organisation |
Gene therapy
|
JP2000501171A
(ja)
|
1995-09-15 |
2000-02-02 |
メルク エンド カンパニー インコーポレーテッド |
融合タンパク質を用いるハイスループットアッセイ
|
US5723313A
(en)
|
1995-09-27 |
1998-03-03 |
St. Jude Children's Research Hospital |
ARF-p19, a novel regulator of the mammalian cell cycle
|
US5684152A
(en)
|
1995-09-28 |
1997-11-04 |
Merck & Co., Inc. |
Preparation of carboxyalkyl derivatives as inhibitors of matrix metalloproteinases
|
US5665777A
(en)
|
1995-11-14 |
1997-09-09 |
Abbott Laboratories |
Biphenyl hydroxamate inhibitors of matrix metalloproteinases
|
ATE225779T1
(de)
|
1995-11-17 |
2002-10-15 |
Warner Lambert Co |
Sulfonamidinhibitoren von matrix metalloproteinasen
|
US5830727A
(en)
|
1995-11-18 |
1998-11-03 |
Human Gene Therapy Research Institute |
Herpes simplex virus amplicon mini-vector gene transfer system
|
US6127427A
(en)
|
1995-11-23 |
2000-10-03 |
British Biotech Pharmaceuticals Limited |
Metalloproteinase inhibitors
|
US5843903A
(en)
|
1995-11-27 |
1998-12-01 |
The Administrators Of The Tulane Educational Fund |
Targeted cytotoxic anthracycline analogs
|
US6117633A
(en)
|
1995-12-08 |
2000-09-12 |
University Technologies International Inc. |
DNA sequence encoding the tumor suppressor gene ING1
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
DE69636289T2
(de)
|
1995-12-18 |
2007-05-10 |
Angiodevice International Gmbh |
Vernetzten polymerisatmassen und verfahren für ihre verwendung
|
US5752974A
(en)
*
|
1995-12-18 |
1998-05-19 |
Collagen Corporation |
Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Hoffmann La Roche |
Matrix-metalloprotease Inhibitoren
|
CZ287868B6
(en)
|
1995-12-22 |
2001-02-14 |
Warner Lambert Co |
Aromatic keto-acids and their derivatives functioning as inhibitors of matrix metalloproteinases
|
DE19548624A1
(de)
|
1995-12-23 |
1997-06-26 |
Boehringer Mannheim Gmbh |
Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
|
DE69728375T2
(de)
|
1996-01-02 |
2005-02-10 |
Aventis Pharmaceuticals Inc. |
Substituierte (aryl, heteroaryl, arylmethyl oder heteroarylmethyl) hydroxamisaeureverbindungen
|
US6054472A
(en)
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
US5807876A
(en)
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
US5744349A
(en)
|
1996-03-05 |
1998-04-28 |
Washington University |
DNA sequences encoding human Myt1 kinase
|
GB9607119D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
GB9607249D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
GB9607120D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
WO1997038091A1
(en)
|
1996-04-10 |
1997-10-16 |
Sloan-Kettering Institute For Cancer Research |
METHODS FOR ENHANCING ANIMAL GROWTH AND CELL PROLIFERATION BY ELIMINATION OF FUNCTIONAL p27?Kip1¿
|
TR199802136T2
(xx)
|
1996-04-23 |
2001-06-21 |
Vertex Pharmaceuticals Incorporated |
�MPDH enzimi inhibit�rleri olarak �re t�revleri.
|
US6128582A
(en)
|
1996-04-30 |
2000-10-03 |
Vertex Pharmaceuticals Incorporated |
Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
|
US5932577A
(en)
|
1996-05-15 |
1999-08-03 |
Bayer Corporation |
Substituted oxobutyric acids as matrix metalloprotease inhibitors
|
US5968795A
(en)
|
1996-05-15 |
1999-10-19 |
Bayer Corporation |
Biaryl acetylenes as inhibitors of matrix metalloproteases
|
US5863915A
(en)
|
1996-05-15 |
1999-01-26 |
Bayer Corporation |
Substituted 4-arylbutyric acid derivatives as matrix metalloprotease
|
US5925637A
(en)
|
1997-05-15 |
1999-07-20 |
Bayer Corporation |
Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids
|
AU736316B2
(en)
|
1996-05-20 |
2001-07-26 |
Signal Pharmaceuticals, Inc. |
Mitogen-activated protein kinase p38-2 and methods of use therefor
|
DE69719385T2
(de)
|
1996-06-21 |
2003-12-18 |
Upjohn Co |
Mmp-hemmende thiadiazolylamide
|
US5852213A
(en)
|
1996-07-10 |
1998-12-22 |
American Cyanamid Company |
Mercaptoketones and mercaptoalcohols and a process for their preparation
|
AU735648B2
(en)
|
1996-07-12 |
2001-07-12 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
KR20000067904A
(ko)
|
1996-07-18 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
매트릭스 메탈로프로테아제의 포스피네이트계 억제제
|
CZ16799A3
(cs)
|
1996-07-22 |
1999-06-16 |
Monsanto Company |
Thiolsulfonové inhibitory metaloproteázy
|
US6566384B1
(en)
|
1996-08-07 |
2003-05-20 |
Darwin Discovery Ltd. |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
|
IT1284876B1
(it)
|
1996-08-07 |
1998-05-22 |
Applied Research Systems |
Hcg come inibitore della collagenasi
|
DE69729007T2
(de)
|
1996-08-07 |
2005-04-07 |
Darwin Discovery Ltd., Slough |
Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
|
GB9616643D0
(en)
|
1996-08-08 |
1996-09-25 |
Chiroscience Ltd |
Compounds
|
JP2000516607A
(ja)
|
1996-08-16 |
2000-12-12 |
ワーナー―ランバート・コンパニー |
酪酸マトリックスメタロプロテイナーゼ阻害剤
|
PL331854A1
(en)
|
1996-08-28 |
1999-08-16 |
Procter & Gamble |
Phosphinamides as inhibitors of metaloprotease matrix
|
AU4159197A
(en)
|
1996-09-04 |
1998-03-26 |
Warner-Lambert Company |
Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
US6624177B1
(en)
|
1996-09-04 |
2003-09-23 |
Warner-Lambert Company |
Matrix metalloproteinase inhibitors and their therapeutic uses
|
AU736347B2
(en)
|
1996-09-04 |
2001-07-26 |
Warner-Lambert Company |
Compounds for and a method of inhibiting matrix metalloproteinases
|
US6022948A
(en)
|
1996-09-17 |
2000-02-08 |
Washington University |
Method of cell surface activation and inhibition
|
CA2266478C
(en)
|
1996-09-23 |
2002-11-12 |
Focal, Inc. |
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
|
IL128900A0
(en)
|
1996-09-27 |
2000-01-31 |
Upjohn Co |
Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitor
|
US5977408A
(en)
|
1996-10-16 |
1999-11-02 |
American Cyanamid Company |
Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
US5929097A
(en)
|
1996-10-16 |
1999-07-27 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
US6548524B2
(en)
|
1996-10-16 |
2003-04-15 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
US5962481A
(en)
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
US6228869B1
(en)
|
1996-10-16 |
2001-05-08 |
American Cyanamid Company |
Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
GB9621814D0
(en)
|
1996-10-19 |
1996-12-11 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
ATE212619T1
(de)
|
1996-10-22 |
2002-02-15 |
Upjohn Co |
Alpha-amino sulfonyl hydroxamsäure als matrix metalloproteinase inhibitoren
|
US5994132A
(en)
|
1996-10-23 |
1999-11-30 |
University Of Michigan |
Adenovirus vectors
|
MY117687A
(en)
|
1996-10-31 |
2004-07-31 |
Bayer Corp |
Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors
|
JPH10130217A
(ja)
|
1996-11-01 |
1998-05-19 |
Kotobuki Seiyaku Kk |
カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物
|
US5965441A
(en)
|
1996-11-13 |
1999-10-12 |
The General Hospital Coporation |
HSV/AAV hybrid amplicon vectors
|
EP0968284B1
(de)
|
1996-11-20 |
2006-12-13 |
Introgen Therapeutics, Inc. |
Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren
|
IL128545A0
(en)
|
1996-12-09 |
2000-01-31 |
Warner Lambert Co |
Method for treating and preventing heart failure and ventricular dilatation
|
ZA9711121B
(en)
|
1996-12-13 |
1998-06-23 |
Handelman Joseph H |
Reduction of hair growth.
|
KR20000057595A
(ko)
|
1996-12-17 |
2000-09-25 |
후지야마 아키라 |
Mmp 또는 tnf의 억제제로서 피페라진 화합물
|
NZ334925A
(en)
|
1996-12-17 |
2001-06-29 |
Warner Lambert Co |
Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing using 2-(4'-bromobiphenyl-4-sulfonylamino)-3-methyl-butyric acid and 4-(4'-chloro-biphenyl-4-yl)-4-hydroxyimino-butyric acid
|
US5985911A
(en)
|
1997-01-07 |
1999-11-16 |
Abbott Laboratories |
C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
|
US5952320A
(en)
|
1997-01-07 |
1999-09-14 |
Abbott Laboratories |
Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
|
US6153436A
(en)
|
1997-01-10 |
2000-11-28 |
The Board Of Trustees Of The University Of Arkansas |
Method of gene delivery using wildtype adeno associated viral (AAV) vectors with insertions
|
AU720615B2
(en)
|
1997-01-17 |
2000-06-08 |
Pharmacia & Upjohn Company |
Bis-sulfonomides hydroxamic acids as MMP inhibitors
|
GB9702088D0
(en)
|
1997-01-31 |
1997-03-19 |
Pharmacia & Upjohn Spa |
Matrix metalloproteinase inhibitors
|
WO1998035022A1
(en)
|
1997-02-06 |
1998-08-13 |
Osiris Therapeutics, Inc. |
p21?CIP1 OR p27KIP1¿ EFFECTS ON THE REGULATION OF DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS
|
AU737376B2
(en)
|
1997-02-25 |
2001-08-16 |
Regents Of The University Of Michigan, The |
Methods and compositions for preventing and treating chronological aging in human skin
|
US6197791B1
(en)
|
1997-02-27 |
2001-03-06 |
American Cyanamid Company |
N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
|
US6172057B1
(en)
|
1997-02-27 |
2001-01-09 |
American Cyanamid Company |
N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
|
DE69828783T2
(de)
|
1997-03-04 |
2006-01-12 |
Pharmacia Corp. |
Hydroxamsäure-sulfonamid-derivate mit amidiertem aromatischen ring
|
EA199900792A1
(ru)
|
1997-03-04 |
2000-04-24 |
Монсанто Компани |
Сульфонильные двухвалентные арильные или гетероарильные соединения гидроксамовой кислоты
|
WO1998039315A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
|
US6362183B1
(en)
|
1997-03-04 |
2002-03-26 |
G. D. Searle & Company |
Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
|
US6087359A
(en)
|
1997-03-04 |
2000-07-11 |
Getman; Daniel P. |
Thioaryl sulfonamide hydroxamic acid compounds
|
US6476027B1
(en)
|
1997-03-04 |
2002-11-05 |
Monsanto Company |
N-hydroxy 4-sulfonyl butanamide compounds
|
US5932600A
(en)
|
1997-03-14 |
1999-08-03 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
AU6701598A
(en)
|
1997-03-14 |
1998-09-29 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
US20020111495A1
(en)
|
1997-04-04 |
2002-08-15 |
Pfizer Inc. |
Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
|
GB9707333D0
(en)
|
1997-04-11 |
1997-05-28 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
US6020191A
(en)
|
1997-04-14 |
2000-02-01 |
Genzyme Corporation |
Adenoviral vectors capable of facilitating increased persistence of transgene expression
|
US5756545A
(en)
|
1997-04-21 |
1998-05-26 |
Warner-Lambert Company |
Biphenysulfonamide matrix metal alloproteinase inhibitors
|
FR2762315B1
(fr)
|
1997-04-22 |
1999-05-28 |
Logeais Labor Jacques |
Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha
|
JP4390860B2
(ja)
|
1997-05-13 |
2009-12-24 |
ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
レンチウイルスをベースにした遺伝子転移ベクター
|
US5932763A
(en)
|
1997-05-15 |
1999-08-03 |
Bayer Corporation |
Inhibition of matrix metalloproteases by 2-(ω-arolalkyl)-4-biaryl-4-oxobutyric acids
|
US5804581A
(en)
|
1997-05-15 |
1998-09-08 |
Bayer Corporation |
Inhibition of matrix metalloproteases by substituted phenalkyl compounds
|
GB9710490D0
(en)
|
1997-05-21 |
1997-07-16 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
TWI234467B
(en)
|
1997-06-04 |
2005-06-21 |
Univ Michigan |
Composition for inhibiting photoaging of skin
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
US6300514B1
(en)
|
1997-06-25 |
2001-10-09 |
Ono Pharmaceutical Co., Ltd. |
Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
|
GB9713726D0
(en)
|
1997-06-30 |
1997-09-03 |
Ciba Geigy Ag |
Organic compounds
|
AU8479498A
(en)
|
1997-07-08 |
1999-02-08 |
Cold Spring Harbor Laboratory |
Dual specificity phosphatase and methods of use
|
US6482827B1
(en)
|
1997-07-10 |
2002-11-19 |
Pharmacia & Upjohn S.P.A. |
Matrix metalloproteinase inhibitors
|
GB9714971D0
(en)
|
1997-07-16 |
1997-09-24 |
Cancer Res Campaign Tech |
Assays,therapeutic methods and means
|
GB9715030D0
(en)
|
1997-07-18 |
1997-09-24 |
British Biotech Pharm |
Metalloproteinase inhibitors
|
US6221646B1
(en)
|
1997-07-31 |
2001-04-24 |
Chiron Corporation |
Materials and methods for simplified AAV production
|
US6235786B1
(en)
|
1997-08-06 |
2001-05-22 |
Abbott Laboratories |
Reverse hydroxamate inhibitors of matrix metalloproteinases
|
US6162241A
(en)
|
1997-08-06 |
2000-12-19 |
Focal, Inc. |
Hemostatic tissue sealants
|
US6294573B1
(en)
|
1997-08-06 |
2001-09-25 |
Abbott Laboratories |
Reverse hydroxamate inhibitors of matrix metalloproteinases
|
US5854382A
(en)
*
|
1997-08-18 |
1998-12-29 |
Meadox Medicals, Inc. |
Bioresorbable compositions for implantable prostheses
|
EP0897908A1
(de)
|
1997-08-19 |
1999-02-24 |
Roche Diagnostics GmbH |
3-Aryl-Succinamido-Hydroxamsäuren, Prozesse zu ihrer Herstellung und diese Substanzen enthaltende Medikamente
|
US6342507B1
(en)
|
1997-09-05 |
2002-01-29 |
Isotechnika, Inc. |
Deuterated rapamycin compounds, method and uses thereof
|
US6448058B1
(en)
|
1997-09-12 |
2002-09-10 |
Versicor, Inc. |
Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
|
GB9719426D0
(en)
|
1997-09-13 |
1997-11-12 |
Johnson Matthey Plc |
Novel process
|
US5997895A
(en)
|
1997-09-16 |
1999-12-07 |
Integra Lifesciences Corporation |
Dural/meningeal repair product using collagen matrix
|
WO2000000600A2
(en)
|
1997-09-22 |
2000-01-06 |
Chang Lung Ji |
Lentiviral vectors, comprising modified major donor splice sites and major packaging signals
|
DE69830663T2
(de)
|
1997-09-24 |
2006-05-11 |
The Regents Of The University Of California, Oakland |
Nicht-Primaten-Lentivirus-Vektoren und Verpackungssysteme
|
US6080874A
(en)
|
1997-09-25 |
2000-06-27 |
Abbott Laboratories |
Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea
|
JPH11106775A
(ja)
|
1997-10-03 |
1999-04-20 |
Taiho Kogyo Co Ltd |
固体潤滑被膜組成物及びそれを用いた滑り軸受材料
|
US6399612B1
(en)
|
1997-10-06 |
2002-06-04 |
Warner-Lambert Company |
Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
US6420427B1
(en)
|
1997-10-09 |
2002-07-16 |
Ono Pharmaceutical Co., Ltd. |
Aminobutyric acid derivatives
|
NZ503685A
(en)
|
1997-10-20 |
2002-05-31 |
F |
Fused pyrrole compounds as kinase inhibitors
|
WO1999024464A1
(en)
|
1997-11-10 |
1999-05-20 |
Dana-Farber Cancer Institute, Inc |
Glycosylated modified primate lentivirus envelope polypeptides
|
JP2001522843A
(ja)
|
1997-11-12 |
2001-11-20 |
ダーウィン・ディスカバリー・リミテッド |
Mmpおよびtnf抑制作用を有するヒドロキサム酸およびカルボン酸誘導体
|
US6063786A
(en)
|
1997-11-12 |
2000-05-16 |
Darwin Discovery, Ltd. |
Heterocyclic compounds having MMP and TNF inhibitory activity
|
US6187924B1
(en)
|
1997-11-12 |
2001-02-13 |
Darwin Discovery, Ltd. |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
|
TR200001391T2
(tr)
|
1997-11-21 |
2000-11-21 |
Pharmacia & Upjohn Company |
Matris metaloproteinaz önleyicileri olarak beta-sülfonil hidroksamik asitlerin alfa-hidroksi, -amino ve halo türevleri.
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
CA2314683A1
(en)
|
1997-12-12 |
1999-06-24 |
Luigi Naldini |
Therapeutic use of lentiviral vectors
|
US6335156B1
(en)
|
1997-12-18 |
2002-01-01 |
The Johns Hopkins University School Of Medicine |
14-3-3σ arrests the cell cycle
|
KR20010033473A
(ko)
|
1997-12-23 |
2001-04-25 |
로즈 암스트롱, 크리스틴 에이. 트러트웨인 |
Ace 저해제-mmp 저해제의 병용 제제
|
US5994099A
(en)
|
1997-12-31 |
1999-11-30 |
The University Of Wyoming |
Extremely elastic spider silk protein and DNA coding therefor
|
AU736511B2
(en)
|
1998-01-09 |
2001-07-26 |
Pfizer Inc. |
Matrix metalloprotease inhibitors
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
US6071903A
(en)
|
1998-01-27 |
2000-06-06 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
|
GB9804504D0
(en)
|
1998-03-03 |
1998-04-29 |
Leo Pharm Prod Ltd |
Matrix metalloproteinase inhibitors
|
US6169103B1
(en)
|
1998-03-03 |
2001-01-02 |
Warner-Lambert |
Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
US6037361A
(en)
|
1998-03-09 |
2000-03-14 |
Warner-Lambert Company |
Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
IL131217A0
(en)
*
|
1998-03-10 |
2001-01-28 |
Napro Biotherapeutics Inc |
Novel methods and compositions for delivery of taxanes
|
US6100032A
(en)
|
1998-03-13 |
2000-08-08 |
Johns Hopkins University |
Human Smad3 and Smad4 are sequence-specific transcription activators
|
FI980604A0
(fi)
|
1998-03-18 |
1998-03-18 |
Univ Helsinki Licensing |
Nya matrismetalloproteinasinhibitorer och -regulatorer
|
EP1064389B1
(de)
|
1998-03-27 |
2007-05-02 |
The Scripps Research Institute |
Zusammensetzungen mit fusionsproteinen der kinase wee1, nukleotidsequenzen, expressionsysteme und verfahren zu deren verwendung
|
US6277061B1
(en)
|
1998-03-31 |
2001-08-21 |
The Research Foundation Of State University Of New York |
Method of inhibiting membrane-type matrix metalloproteinase
|
WO1999051754A1
(en)
|
1998-04-02 |
1999-10-14 |
Dana-Farber Cancer Institute, Inc. |
Infectious pseudotyped lentiviral vectors lacking matrix protein and uses thereof
|
GT199900044A
(es)
|
1998-04-10 |
2000-09-14 |
|
Procedimientos para preparar haluros de fenoxifenilsulfonilo.
|
PA8469601A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Procedimiento para alquilar sulfonamidas impedidas estericamente
|
DE69917124T2
(de)
|
1998-04-10 |
2005-05-12 |
Pfizer Products Inc., Groton |
Cyclobutyl-Aryloxysulfonylamin-Hydroxamsäurederivate
|
AU3665199A
(en)
|
1998-04-29 |
1999-11-16 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
JPH11313675A
(ja)
|
1998-04-30 |
1999-11-16 |
Hoechst Marion Roussel Kk |
ヒトbmp−7プロモーターおよびこれを用いた骨関連物質の探索法
|
US6316466B1
(en)
|
1998-05-05 |
2001-11-13 |
Syntex (U.S.A.) Llc |
Pyrazole derivatives P-38 MAP kinase inhibitors
|
US20020156114A1
(en)
|
1998-05-05 |
2002-10-24 |
Goldstein David Michael |
Pyrazole derivatives - p38 MAP kinase inhibitors
|
US6376527B1
(en)
|
1998-05-05 |
2002-04-23 |
Syntex (U.S.A.) Llc |
Pyrazole derivatives-p38 map kinase inhibitors
|
AU3859999A
(en)
|
1998-05-14 |
1999-11-29 |
G.D. Searle & Co. |
1,5-diaryl substituted pyrazoles as p38 kinase inhibitors
|
US6288063B1
(en)
|
1998-05-27 |
2001-09-11 |
Bayer Corporation |
Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
|
US6113913A
(en)
|
1998-06-26 |
2000-09-05 |
Genvec, Inc. |
Recombinant adenovirus
|
US6168807B1
(en)
|
1998-07-23 |
2001-01-02 |
Les Laboratoires Aeterna Inc. |
Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
|
WO2000006560A1
(en)
|
1998-07-30 |
2000-02-10 |
Warner-Lambert Company |
Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
|
AU758619B2
(en)
|
1998-07-30 |
2003-03-27 |
Warner-Lambert Company |
Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
|
US6117869A
(en)
|
1998-08-04 |
2000-09-12 |
Warner-Lambert Company |
Compounds for and methods of inhibiting matrix metalloproteinases
|
US6514534B1
(en)
|
1998-08-14 |
2003-02-04 |
Incept Llc |
Methods for forming regional tissue adherent barriers and drug delivery systems
|
JP2002523492A
(ja)
|
1998-08-29 |
2002-07-30 |
ブリティッシュ バイオテック ファーマシューティカルズ リミテッド |
タンパク質分解酵素阻害剤としてのヒドロキサム酸誘導体
|
US6509337B1
(en)
|
1998-09-17 |
2003-01-21 |
Pfizer Inc. |
Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
|
WO2000017162A1
(fr)
|
1998-09-21 |
2000-03-30 |
Takeda Chemical Industries, Ltd. |
Nouveaux derives de thiol, leur procede de production et leur utilisation
|
WO2000024725A1
(en)
|
1998-10-26 |
2000-05-04 |
Vertex Pharmaceuticals Incorporated |
Pentacyclic compounds useful as inhibitors of hepatitis c virus ns3 helicase
|
CA2348234A1
(en)
|
1998-10-29 |
2000-05-11 |
Chunjian Liu |
Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
|
US6596747B2
(en)
|
1998-10-29 |
2003-07-22 |
Bristol-Myers Squibb Company |
Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
|
AU1707700A
(en)
|
1998-10-29 |
2000-05-22 |
Bristol-Myers Squibb Company |
Novel inhibitors of impdh enzyme
|
US6420403B1
(en)
|
1998-10-29 |
2002-07-16 |
Edwin J. Iwanowicz |
Inhibitors of IMPDH enzyme
|
US6210922B1
(en)
|
1998-11-30 |
2001-04-03 |
National Research Council Of Canada |
Serum free production of recombinant proteins and adenoviral vectors
|
WO2000032765A2
(en)
|
1998-12-04 |
2000-06-08 |
Immusol, Inc. |
Ribozyme therapy for the treatment and/or prevention of restenosis
|
EP1137373A4
(de)
|
1998-12-04 |
2004-05-19 |
Chandrashekhar P Pathak |
Biokompatible, vernetzte polymere
|
US6328229B1
(en)
|
1998-12-18 |
2001-12-11 |
Cohesion Technologies, Inc. |
Low volume mixing spray head for mixing and dispensing of two reactive fluid components
|
US6288261B1
(en)
|
1998-12-18 |
2001-09-11 |
Abbott Laboratories |
Inhibitors of matrix metalloproteinases
|
US6544980B2
(en)
|
1998-12-31 |
2003-04-08 |
Aventis Pharmaceuticals Inc. |
N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
|
US6486193B2
(en)
|
1998-12-31 |
2002-11-26 |
Aventis Pharmaceuticals Inc. |
3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
|
US6329550B1
(en)
|
1998-12-31 |
2001-12-11 |
Aventis Pharmaceuticals Inc. |
Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase
|
US6262080B1
(en)
|
1998-12-31 |
2001-07-17 |
Avantis Pharmaceuticals Inc. |
3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
|
US6352976B1
(en)
|
1998-12-31 |
2002-03-05 |
Aventis Pharmaceuticals Inc. |
Selective inhibitors of MMP-12
|
US6294539B1
(en)
|
1999-01-19 |
2001-09-25 |
Advanced Syntech, Llc |
Heterocyclic hydroxamic acid derivatives as MMP inhibitors
|
BR0007784A
(pt)
|
1999-01-27 |
2002-02-05 |
American Cyanamid Co |
Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto
|
SK11352001A3
(sk)
|
1999-02-08 |
2002-09-10 |
G. D. Searle & Co. |
Metaloproteázový inhibítor kyselina sulfamátohydroxámová
|
GB9903598D0
(en)
|
1999-02-18 |
1999-04-07 |
Univ Manchester |
Connective tissue healing
|
US6514979B1
(en)
|
1999-03-03 |
2003-02-04 |
University Of Maryland Biotechnology Institute |
Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
|
EE200100492A
(et)
|
1999-03-19 |
2002-12-16 |
Vertex Pharmaceuticals Incorporated |
Ensüümi IMPDH inhibiitorid
|
AU4181000A
(en)
|
1999-04-02 |
2000-10-23 |
Du Pont Pharmaceuticals Company |
Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
|
JP2002541138A
(ja)
|
1999-04-02 |
2002-12-03 |
デュポン ファーマシューティカルズ カンパニー |
マトリックスメタロプロテアーゼ、TNF−α、およびアグレカナーゼの阻害剤としての新規アミド誘導体
|
EP1167346A4
(de)
|
1999-04-06 |
2003-07-23 |
Ono Pharmaceutical Co |
Derivate der 4-aminobutansäure und medikamente die diese derivate als aktive wirkstoffe enthalten
|
CO5170501A1
(es)
|
1999-04-14 |
2002-06-27 |
Novartis Ag |
AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
|
US6312725B1
(en)
|
1999-04-16 |
2001-11-06 |
Cohesion Technologies, Inc. |
Rapid gelling biocompatible polymer composition
|
EP1172361A4
(de)
|
1999-04-19 |
2002-05-08 |
Shionogi & Co |
Sulfonamidderivate mit oxadiazolringen
|
US6287588B1
(en)
*
|
1999-04-29 |
2001-09-11 |
Macromed, Inc. |
Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
|
ATE368122T1
(de)
|
1999-04-29 |
2007-08-15 |
Cell Genesys Inc |
Verfahren und mittel für die herstellung von sicheren rekombinanten lentiviralen vektoren mit hohem titer
|
US6509361B1
(en)
|
1999-05-12 |
2003-01-21 |
Pharmacia Corporation |
1,5-Diaryl substituted pyrazoles as p38 kinase inhibitors
|
US6583299B1
(en)
|
1999-05-20 |
2003-06-24 |
G.D. Searle & Co. |
α-amino-β-sulfonyl hydroxamic acid compounds
|
JP4070409B2
(ja)
|
1999-05-24 |
2008-04-02 |
塩野義製薬株式会社 |
マトリックスメタロプロテアーゼ阻害活性の評価方法
|
AU5031200A
(en)
|
1999-05-28 |
2000-12-18 |
Vertex Pharmaceuticals Incorporated |
Method for preparing 5-substituted oxazoles
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
JP3362778B2
(ja)
|
1999-06-03 |
2003-01-07 |
独立行政法人農業生物資源研究所 |
結晶性絹超微粉末の製造方法
|
US6294694B1
(en)
|
1999-06-04 |
2001-09-25 |
Wisconsin Alumni Research Foundation |
Matrix metalloproteinase inhibitors and method of using same
|
MXPA02000294A
(es)
|
1999-06-25 |
2002-06-21 |
Vertex Pharma |
Profarmacos de carbamatos inhibidores de impdh.
|
US6541521B1
(en)
|
1999-07-12 |
2003-04-01 |
Warner-Lambert Company |
Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
|
KR20010010393A
(ko)
*
|
1999-07-20 |
2001-02-05 |
김윤 |
소수성 고분자와 친수성 고분자의 생분해성 블록 공중합체 및이를 포함하는 약물 전달체 조성물
|
AU6866700A
(en)
|
1999-09-01 |
2001-03-26 |
Ajinomoto Co., Inc. |
Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof
|
IL138686A0
(en)
|
1999-10-01 |
2001-10-31 |
Pfizer Prod Inc |
α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS
|
SE9904177D0
(sv)
|
1999-11-18 |
1999-11-18 |
Astra Ab |
Novel compounds
|
GB9929979D0
(en)
|
1999-12-17 |
2000-02-09 |
Darwin Discovery Ltd |
Hydroxamic acid derivatives
|
US6380253B1
(en)
|
2000-01-05 |
2002-04-30 |
Efa Sciences Llc |
Method of stabilizing and potentiating the action of anti-angiogenic substances
|
NZ519726A
(en)
|
2000-01-31 |
2004-05-28 |
Pfizer Prod Inc |
Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes
|
PT1252158E
(pt)
|
2000-01-31 |
2005-09-30 |
Pfizer Prod Inc |
Derivados heterociclilo benzo-condensado de nicotinamida uteis como inibidores selectivos de isozimas pde4
|
EP1257257B1
(de)
|
2000-02-17 |
2018-10-31 |
Neomend, Inc. |
Verfahren zur herstellung von abgabesystemen verwendend zusammensetzungen aus vorgeformtem biologisch abbaubarem polymer
|
US6867299B2
(en)
|
2000-02-24 |
2005-03-15 |
Hoffmann-La Roche Inc. |
Oxamide IMPDH inhibitors
|
US6465508B1
(en)
|
2000-02-25 |
2002-10-15 |
Wyeth |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
|
CA2399921A1
(en)
|
2000-03-03 |
2001-09-13 |
Human Genome Sciences, Inc. |
Protein tyrosine phosphatase polynucleotides, polypeptides, and antibodies
|
US6458822B2
(en)
|
2000-03-13 |
2002-10-01 |
Pfizer Inc. |
2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
|
EP1263756B1
(de)
|
2000-03-17 |
2004-02-25 |
Bristol-Myers Squibb Pharma Company |
Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren
|
WO2001074811A2
(en)
|
2000-03-30 |
2001-10-11 |
Takeda Chemical Industries, Ltd. |
Substituted 1,3-thiazole compounds, their production and use
|
US20020019539A1
(en)
|
2000-03-31 |
2002-02-14 |
Bailey Anne E. |
Process for the preparation of matrix metalloproteinase inhibitors
|
WO2001077092A1
(en)
|
2000-04-07 |
2001-10-18 |
Samsung Electronics Co., Ltd. |
Sulfonamide derivative as a matrix metalloproteinase inhibitor
|
KR20100003313A
(ko)
|
2000-04-13 |
2010-01-07 |
파마셋 인코포레이티드 |
간염 바이러스 감염 치료를 위한 3'- 또는 2'-하이드록시메틸 치환된 뉴클레오시드 유도체
|
AU2001255538B2
(en)
|
2000-04-24 |
2006-03-30 |
Bristol-Myers Squibb Company |
Heterocycles that are inhibitors of IMPDH enzyme
|
US6503892B2
(en)
|
2000-04-26 |
2003-01-07 |
New England Medical Center Hospitals Inc. |
Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve
|
JP2004514409A
(ja)
|
2000-05-10 |
2004-05-20 |
ブリストル−マイヤーズ スクイブ カンパニー |
修飾イノシン5’−一リン酸デヒドロゲナーゼポリペプチドおよびその用途
|
WO2001087883A1
(en)
|
2000-05-15 |
2001-11-22 |
Darwin Discovery Limited |
Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
|
CN1443190A
(zh)
|
2000-07-18 |
2003-09-17 |
里奥制药有限公司 |
基质金属蛋白酶抑制剂
|
CZ2003460A3
(cs)
|
2000-08-22 |
2003-10-15 |
Ribapharm Inc. |
Způsob zvýšení selektivity, snížení cytoxicity a dávky léčebného prostředku
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
KR100582325B1
(ko)
|
2000-08-31 |
2006-05-22 |
에프. 호프만-라 로슈 아게 |
7-옥소 피리도피리미딘
|
US6455570B1
(en)
|
2000-10-06 |
2002-09-24 |
The Trustees Of The University Of Pennsylvania |
Polypyrrolinone based inhibitors of matrix metalloproteases
|
US20020151491A1
(en)
|
2000-11-28 |
2002-10-17 |
Jian-Dong Li |
Composition and method for treating the over-production of mucin in diseases such as otitis media using an inhibitor of MUC5AC
|
CA2432287A1
(en)
|
2000-12-15 |
2002-09-06 |
Triangle Pharmaceuticals, Inc. |
Dapd combination therapy with inosine monophosphate dehydrogenase inhibitor
|
DE10064997A1
(de)
|
2000-12-23 |
2002-06-27 |
Merck Patent Gmbh |
Benzoylpyridazine
|
US6600057B2
(en)
|
2000-12-29 |
2003-07-29 |
Kimberly-Clark Worldwide, Inc. |
Matrix metalloproteinase inhibitors
|
EP1355648A2
(de)
|
2001-01-11 |
2003-10-29 |
Bristol-Myers Squibb Pharma Company |
ZWEIFACH in 1,2-POSITION SUBSTITUIERTE CYCLISCHE HEMMER VON MATRIXMETALLOPROTEASEN UND TNF-$g(a)
|
SK286630B6
(sk)
|
2001-01-22 |
2009-02-05 |
Merck & Co., Inc. |
Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
|
HUP0400637A2
(hu)
|
2001-01-31 |
2004-06-28 |
Pfizer Products Inc. |
Nikotinamid-biaril-származékok, amelyek PDE4 izozimek inhibitoraiként alkalmazhatók és ezeket tartalmazó gyógyszerkészítmények
|
EE200300362A
(et)
|
2001-01-31 |
2003-12-15 |
Pfizer Products Inc. |
PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid
|
NZ526531A
(en)
|
2001-01-31 |
2005-02-25 |
Pfizer Prod Inc |
Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
|
AU2002256615B2
(en)
|
2001-02-12 |
2007-09-13 |
F. Hoffmann-La Roche Ag |
6-substituted pyrido-pyrimidines
|
MXPA01013172A
(es)
|
2001-02-14 |
2002-08-21 |
Warner Lambert Co |
Inhibidores sulfonamida de metaloproteinasa de matriz.
|
MXPA01013171A
(es)
|
2001-02-14 |
2004-05-21 |
Warner Lambert Co |
Inhibidores triciclicos de sulfonamida de metaloproteinasa de matriz.
|
CA2440935A1
(en)
|
2001-03-13 |
2002-09-19 |
Richard Liggins |
Micellar drug delivery vehicles and precursors thereto and uses thereof
|
US20030073832A1
(en)
|
2001-04-10 |
2003-04-17 |
Havez Sophie Elisabeth |
Novel aminophenyl ketone derivatives
|
US20030012818A1
(en)
*
|
2001-04-25 |
2003-01-16 |
Eidgenossische Technische Hochschule Zurich And Universitat Zurich |
Drug delivery matrices to enhance wound healing
|
US20030166201A1
(en)
|
2001-04-30 |
2003-09-04 |
Jensen Michael C. |
Selection systems for genetically modified cells
|
AU2002257456A1
(en)
|
2001-05-24 |
2002-12-03 |
University Of Western Ontario |
Control of myogenesis by modulation of p38 map kinase activity
|
CA2447475A1
(en)
|
2001-05-25 |
2002-12-05 |
Chu-Biao Xue |
Hydantion derivatives as inhibitors of matrix metalloproteinases
|
EP1407005A4
(de)
|
2001-06-11 |
2006-05-31 |
Interleukin Genetics Inc |
Integrative assays zur überwachung molekularer zusammenbauereignisse
|
WO2002103000A2
(en)
|
2001-06-15 |
2002-12-27 |
National Research Council Of Canada |
Methods for modulating gap junctions
|
GB0117506D0
(en)
|
2001-07-18 |
2001-09-12 |
Bayer Ag |
Imidazopyridinones
|
WO2003016248A2
(en)
|
2001-08-17 |
2003-02-27 |
Bristol-Myers Squibb Company Patent Department |
Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
|
US6824769B2
(en)
|
2001-08-28 |
2004-11-30 |
Vertex Pharmaceuticals Incorporated |
Optimal compositions and methods thereof for treating HCV infections
|
AU2002331179B2
(en)
|
2001-08-30 |
2008-04-17 |
F. Hoffmann-La Roche Ag |
Aminopyrrole compounds as antiinflammatory agents
|
EP1427408A4
(de)
|
2001-09-17 |
2005-10-26 |
Bristol Myers Squibb Co |
ZYKLISCHE HYDROXAMINSÄUREN ALS HEMMER VON MATRIX-METALLOPROTEINASEN UND/ODER VON TNF-a-KONVERTASE (TACE TNF-a-CONVERTING ENZYM)
|
US7015217B2
(en)
|
2001-10-09 |
2006-03-21 |
Bristol-Myers Squibb Company |
Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
|
WO2003035066A1
(en)
|
2001-10-23 |
2003-05-01 |
Celltech R & D Limited |
2-aminoquinolone derivatives for use as impdh inhibitors
|
JP2005515975A
(ja)
|
2001-10-31 |
2005-06-02 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
4型ホスホジエステラーゼ阻害剤およびこれらの使用
|
US20030212056A1
(en)
|
2001-11-02 |
2003-11-13 |
Jingwu Duan |
Beta-sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
|
PL369738A1
(en)
|
2001-11-05 |
2005-05-02 |
Merck Patent Gmbh |
Hydrazono-malonitriles
|
ATE481135T1
(de)
|
2001-11-09 |
2010-10-15 |
Intarcia Therapeutics Inc |
Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen
|
WO2003053958A1
(en)
|
2001-12-20 |
2003-07-03 |
Celltech R & D Limited |
Quinazolinedione derivatives
|
AU2002346729A1
(en)
|
2001-12-20 |
2003-07-09 |
Bristol-Myers Squibb Company |
Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
|
AU2002357312A1
(en)
|
2001-12-20 |
2003-07-09 |
Bristol-Myers Squibb Company |
Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases
|
TW200301698A
(en)
|
2001-12-21 |
2003-07-16 |
Bristol Myers Squibb Co |
Acridone inhibitors of IMPDH enzyme
|
MXPA04007124A
(es)
|
2002-02-01 |
2004-10-29 |
Omeros Corp |
Composiciones y metodos para la inhibicion sistemica de la degradacion del cartilago.
|
WO2003079986A2
(en)
|
2002-03-18 |
2003-10-02 |
Bristol-Myers Squibb Company |
Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases
|
JP4611641B2
(ja)
|
2002-03-20 |
2011-01-12 |
エラン ファーマ インターナショナル,リミティド |
Mapキナーゼ阻害剤のナノ粒子組成物
|
AU2003214231A1
(en)
|
2002-03-22 |
2003-10-13 |
Bristol-Myers Squibb Company |
Dpc 333 formulation having unique biopharmaceutical characteristics
|
GB0208224D0
(en)
|
2002-04-10 |
2002-05-22 |
Celltech R&D Ltd |
Chemical compounds
|
GB0208223D0
(en)
|
2002-04-10 |
2002-05-22 |
Celltech R&D Ltd |
Chemical compounds
|
US6620813B1
(en)
|
2002-06-21 |
2003-09-16 |
Medinox, Inc. |
Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
|
AU2003295432A1
(en)
|
2002-11-12 |
2004-06-03 |
Enzon Pharmaceuticals, Inc. |
Prodrugs of vancomycin with hydrolysis resistant polymer linkers
|
DE60331367D1
(de)
|
2002-12-30 |
2010-04-01 |
Angiotech Int Ag |
Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
|