FR2611203B1 - Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2611203B1
FR2611203B1 FR8702449A FR8702449A FR2611203B1 FR 2611203 B1 FR2611203 B1 FR 2611203B1 FR 8702449 A FR8702449 A FR 8702449A FR 8702449 A FR8702449 A FR 8702449A FR 2611203 B1 FR2611203 B1 FR 2611203B1
Authority
FR
France
Prior art keywords
amethopterine
amethopterin
deaza
diphosphonic
gem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8702449A
Other languages
English (en)
Other versions
FR2611203A1 (fr
Inventor
Georges Louis Edmond Sturtz
Patricia Cecile Marie-L Voisin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR8702449A priority Critical patent/FR2611203B1/fr
Priority to PCT/FR1988/000088 priority patent/WO1988006158A1/fr
Publication of FR2611203A1 publication Critical patent/FR2611203A1/fr
Application granted granted Critical
Publication of FR2611203B1 publication Critical patent/FR2611203B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
FR8702449A 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent Expired FR2611203B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8702449A FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1988/000088 WO1988006158A1 (fr) 1987-02-20 1988-02-18 Analogues gem-diphosphoniques d'amethopterine et de deaza-n-10 amethopterine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8702449A FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2611203A1 FR2611203A1 (fr) 1988-08-26
FR2611203B1 true FR2611203B1 (fr) 1989-06-09

Family

ID=9348267

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8702449A Expired FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (2)

Country Link
FR (1) FR2611203B1 (fr)
WO (1) WO1988006158A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030634A (en) * 1990-03-29 1991-07-09 Krumdieck Carlos L 10-deazaaminopterin: a new arthritis remittive drug
FR2661179B1 (fr) * 1990-04-23 1992-08-21 Sturtz Georges Prodrogues gem-disphophoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine, compositions pharmaceutiques contenant de tels prodrogues, procedes d'obtention et produits intermediaires.
AU8495091A (en) * 1990-08-21 1992-03-17 Upjohn Company, The Bisphosphonic acid derivatives as anti-arthritic agents
FR2683528A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique.
FR2683527A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues gem-bisphosphonates de sterouides derives de la cortisone.
JP2746041B2 (ja) * 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体
AU4387893A (en) * 1992-07-16 1994-02-14 Upjohn Company, The Phosphono derivatives as antiinflammatory and antiarthritic agents
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che
IT1290444B1 (it) * 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
CA2481285A1 (fr) 2002-04-26 2003-11-06 Gilead Sciences, Inc. Inhibiteurs non nucleosidiques de la transcriptase inverse
ES2369640T3 (es) 2002-05-24 2011-12-02 Angiotech International Ag Composiciones y métodos para revestir implantes médicos.
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
WO2004096287A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
EA200501676A1 (ru) 2003-04-25 2006-04-28 Джилид Сайэнс, Инк. Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты)
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
WO2004096286A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Analogues de phosphonate antiviraux
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (fr) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Conjugues phosphonate / inhibiteur de purine nucleoside phosphorylase
AU2004286238A1 (en) 2003-10-24 2005-05-12 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
CA2548753A1 (fr) 2003-12-22 2005-07-14 Gilead Sciences, Inc. Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc
DK2258376T3 (en) 2004-07-27 2019-04-15 Gilead Sciences Inc Phosphonate analogues of HIV inhibitor compounds
EP2307435B1 (fr) 2008-07-08 2012-06-13 Gilead Sciences, Inc. Sels de composés inhibiteurs du vih
CA2933579A1 (fr) 2013-12-11 2015-06-18 University Of Massachusetts Compositions et procedes de traitement d'une maladie au moyen d'une proteine effectrice t3ss de salmonella (sipa)
ES2892402T3 (es) 2017-08-01 2022-02-04 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds

Also Published As

Publication number Publication date
FR2611203A1 (fr) 1988-08-26
WO1988006158A1 (fr) 1988-08-25

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