ES2176245T3 - Anticuerpos de ramapicinas de ciclo abierto. - Google Patents
Anticuerpos de ramapicinas de ciclo abierto.Info
- Publication number
- ES2176245T3 ES2176245T3 ES94915854T ES94915854T ES2176245T3 ES 2176245 T3 ES2176245 T3 ES 2176245T3 ES 94915854 T ES94915854 T ES 94915854T ES 94915854 T ES94915854 T ES 94915854T ES 2176245 T3 ES2176245 T3 ES 2176245T3
- Authority
- ES
- Spain
- Prior art keywords
- rapamycin
- antibodies
- ramapicin
- same
- open cycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PROPORCIONAN CONJUGADOS DE RAPAMICINA QUE SON UTILES COMO MOLECULAS INMUNOGENETICAS PARA LA GENERACION DE ANTICUERPOS ESPECIFICOS PARA RAPAMICINA O UN DERIVADO DE LA MISMA, PARA MEDIR NIVELES DE RAPAMICINA O DERIVADOS DE LA MISMA; PARA AISLAR PROTEINAS QUE ENLAZAN RAPAMICINA; Y DETECTAR ANTICUERPOS ESPECIFICOS PARA RAPAMICINA O DERIVADOS DE LA MISMA. ESTA INVENCION TAMBIEN PROPORCIONA ANTICUERPOS MONOCLONALES ESPECIFICOS PARA RAPAMICINA O UN DERIVADO ABIERTO DE ANILLO DE RAPAMICINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5303093A | 1993-04-23 | 1993-04-23 | |
US22420594A | 1994-04-14 | 1994-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176245T3 true ES2176245T3 (es) | 2002-12-01 |
Family
ID=26731364
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01120777T Expired - Lifetime ES2295093T3 (es) | 1993-04-23 | 1994-04-22 | Conjugados y anticuerpos de rapamicina. |
ES94915854T Expired - Lifetime ES2176245T3 (es) | 1993-04-23 | 1994-04-22 | Anticuerpos de ramapicinas de ciclo abierto. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01120777T Expired - Lifetime ES2295093T3 (es) | 1993-04-23 | 1994-04-22 | Conjugados y anticuerpos de rapamicina. |
Country Status (8)
Country | Link |
---|---|
US (2) | US6328970B1 (es) |
EP (2) | EP1181938B1 (es) |
JP (3) | JPH08509499A (es) |
AU (1) | AU686629B2 (es) |
CA (1) | CA2161101A1 (es) |
DE (2) | DE69435044T2 (es) |
ES (2) | ES2295093T3 (es) |
WO (1) | WO1994025022A1 (es) |
Families Citing this family (66)
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---|---|---|---|---|
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
US7279561B1 (en) * | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
DE69435044T2 (de) | 1993-04-23 | 2008-09-18 | Wyeth | Rapamycin - Konjugate und Antikörper |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
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US7078495B1 (en) * | 1999-08-03 | 2006-07-18 | Dade Behring Inc. | Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
ES2219388T3 (es) | 1999-08-24 | 2004-12-01 | Ariad Gene Therapeutics, Inc. | 28-epi-rapalogos. |
ATE427948T1 (de) * | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
CN100522967C (zh) | 2002-02-01 | 2009-08-05 | 阿里亚德基因治疗公司 | 含磷化合物及其应用 |
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DK1592457T3 (da) | 2003-01-27 | 2012-10-22 | Endocyte Inc | Folat-vinblastin-konjugat som lægemiddel |
US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
EP1730525B1 (en) * | 2004-03-10 | 2013-06-19 | Seradyn, Inc. | Immunoassays for everolimus |
DE602005010228D1 (de) | 2004-04-14 | 2008-11-20 | Wyeth Corp | Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper |
CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
EP1776370A1 (en) * | 2004-08-10 | 2007-04-25 | Wyeth a Corporation of the State of Delaware | Cci-779 derivatives and methods of making same |
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JP2008524232A (ja) | 2004-12-20 | 2008-07-10 | ワイス | ラパマイシン誘導体及び神経障害の治療におけるその使用 |
US7276498B2 (en) | 2004-12-20 | 2007-10-02 | Wyeth | Rapamycin analogues and uses thereof in the treatment of neurological disorders |
JP5289935B2 (ja) * | 2005-03-16 | 2013-09-11 | エンドサイト,インコーポレイテッド | プテロイン酸およびその結合体の合成と精製 |
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US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
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ES2574606T3 (es) * | 2009-11-26 | 2016-06-21 | National Taiwan University | Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma |
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JP6525971B2 (ja) | 2013-06-11 | 2019-06-05 | タカラ バイオ ユーエスエー, インコーポレイテッド | タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法 |
TW201511785A (zh) | 2013-07-17 | 2015-04-01 | Sanofi Sa | 顯示器總成及施配裝置 |
US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
CN105461738B (zh) * | 2014-06-03 | 2019-03-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种雷帕霉素衍生物、其制备方法、其药物组合物及用途 |
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US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
DE69435044T2 (de) | 1993-04-23 | 2008-09-18 | Wyeth | Rapamycin - Konjugate und Antikörper |
US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5391730A (en) * | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
SK78196A3 (en) | 1993-12-17 | 1997-02-05 | Sandoz Ag | Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them |
CA2219659C (en) | 1995-06-09 | 2008-03-18 | Novartis Ag | Rapamycin derivatives |
-
1994
- 1994-04-22 DE DE69435044T patent/DE69435044T2/de not_active Expired - Lifetime
- 1994-04-22 AU AU67720/94A patent/AU686629B2/en not_active Expired
- 1994-04-22 WO PCT/US1994/004434 patent/WO1994025022A1/en active IP Right Grant
- 1994-04-22 JP JP6524408A patent/JPH08509499A/ja active Pending
- 1994-04-22 EP EP01120777A patent/EP1181938B1/en not_active Expired - Lifetime
- 1994-04-22 ES ES01120777T patent/ES2295093T3/es not_active Expired - Lifetime
- 1994-04-22 EP EP94915854A patent/EP0710110B1/en not_active Expired - Lifetime
- 1994-04-22 DE DE69430060T patent/DE69430060T2/de not_active Expired - Lifetime
- 1994-04-22 CA CA002161101A patent/CA2161101A1/en not_active Abandoned
- 1994-04-22 ES ES94915854T patent/ES2176245T3/es not_active Expired - Lifetime
-
2000
- 2000-05-24 US US09/576,952 patent/US6328970B1/en not_active Expired - Fee Related
-
2001
- 2001-02-02 US US09/773,562 patent/US6541612B2/en not_active Expired - Fee Related
-
2003
- 2003-12-10 JP JP2003412072A patent/JP2004149542A/ja active Pending
- 2003-12-10 JP JP2003412071A patent/JP2004168782A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1181938A2 (en) | 2002-02-27 |
DE69435044D1 (de) | 2007-12-27 |
DE69435044T2 (de) | 2008-09-18 |
EP0710110A4 (en) | 1997-06-18 |
CA2161101A1 (en) | 1994-11-10 |
US6541612B2 (en) | 2003-04-01 |
DE69430060T2 (de) | 2002-11-07 |
EP1181938B1 (en) | 2007-11-14 |
JP2004168782A (ja) | 2004-06-17 |
AU6772094A (en) | 1994-11-21 |
AU686629B2 (en) | 1998-02-12 |
US6328970B1 (en) | 2001-12-11 |
DE69430060D1 (de) | 2002-04-11 |
EP0710110B1 (en) | 2002-03-06 |
JP2004149542A (ja) | 2004-05-27 |
ES2295093T3 (es) | 2008-04-16 |
EP1181938A3 (en) | 2002-03-20 |
WO1994025022A1 (en) | 1994-11-10 |
JPH08509499A (ja) | 1996-10-08 |
EP0710110A1 (en) | 1996-05-08 |
US20010010920A1 (en) | 2001-08-02 |
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