ATE236904T1 - Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren - Google Patents

Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren

Info

Publication number
ATE236904T1
ATE236904T1 AT97931960T AT97931960T ATE236904T1 AT E236904 T1 ATE236904 T1 AT E236904T1 AT 97931960 T AT97931960 T AT 97931960T AT 97931960 T AT97931960 T AT 97931960T AT E236904 T1 ATE236904 T1 AT E236904T1
Authority
AT
Austria
Prior art keywords
ligands
pyridazine derivatives
gaba receptors
substituted triazolo
triazolo
Prior art date
Application number
AT97931960T
Other languages
English (en)
Inventor
Howard Barff Broughton
William Robert Carling
Pineiro Jose Luis Castro
Alexander Richard Guiblin
Andrew Madin
Kevin William Moore
Michael Geoffrey Russell
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en
Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en
Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE236904T1 publication Critical patent/ATE236904T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97931960T 1996-07-25 1997-07-17 Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren ATE236904T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9615645.0A GB9615645D0 (en) 1996-07-25 1996-07-25 Therapeutic agents
GBGB9625397.6A GB9625397D0 (en) 1996-12-06 1996-12-06 Therapeutic agents
GBGB9714420.8A GB9714420D0 (en) 1997-07-09 1997-07-09 Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en) 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE236904T1 true ATE236904T1 (de) 2003-04-15

Family

ID=27268403

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931960T ATE236904T1 (de) 1996-07-25 1997-07-17 Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren

Country Status (24)

Country Link
US (1) US6255305B1 (de)
EP (1) EP0915875B1 (de)
JP (1) JP4216905B2 (de)
KR (1) KR20000029548A (de)
CN (1) CN1251589A (de)
AT (1) ATE236904T1 (de)
AU (1) AU723098B2 (de)
BG (1) BG103112A (de)
BR (1) BR9710729A (de)
CZ (1) CZ18199A3 (de)
DE (1) DE69720732T2 (de)
EA (1) EA002436B1 (de)
EE (1) EE9900027A (de)
ES (1) ES2194205T3 (de)
HU (1) HUP0600527A2 (de)
IL (1) IL127911A0 (de)
IS (1) IS4949A (de)
NO (1) NO990304L (de)
NZ (1) NZ333768A (de)
PL (1) PL331072A1 (de)
SK (1) SK9399A3 (de)
TR (1) TR199900047T2 (de)
WO (1) WO1998004559A2 (de)
YU (1) YU2899A (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2288789C (en) * 1997-05-08 2009-07-21 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9718254D0 (en) 1997-08-28 1997-11-05 Merck Sharp & Dohme Therapeutic agents
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
AU1041599A (en) * 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (de) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazin-derivate als liganden für gaba-rezeptoren
GB9801208D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
US6579875B1 (en) * 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) * 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) * 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
EP1087968A1 (de) 1998-06-16 2001-04-04 MERCK SHARP & DOHME LTD. Triazolo-pyridin-derivate als liganden für gabarezeptoren
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9813576D0 (en) * 1998-06-24 1998-08-19 Merck Sharp & Dohme Therapeutic agents
GB9821179D0 (en) * 1998-09-30 1998-11-25 Merck Sharp & Dohme Therapeutic use
AU6003099A (en) * 1998-10-06 2000-04-26 Takeda Chemical Industries Ltd. Fused pyridazine compounds, process for the preparation of the same and uses thereof
JP2002527519A (ja) * 1998-10-16 2002-08-27 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体のリガンドとしてのピラゾロトリアジン誘導体
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) * 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
DE60016566T2 (de) 1999-01-27 2005-12-15 Merck Sharp & Dohme Ltd., Hoddesdon Triazolopyridazinderivate als liganden für gaba-rezeptoren
GB9903119D0 (en) * 1999-02-11 1999-04-07 Merck Sharp & Dohme Therapeutic agents
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) 1999-08-23 1999-10-27 Merck Sharp & Dohme Therapeutic agents
GB9921351D0 (en) 1999-09-09 1999-11-10 Merck Sharp & Dohme Therapeutic agents
US6355638B1 (en) * 1999-11-25 2002-03-12 Merck Sharp & Dohme Ltd. Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en) 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929685D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
GB0008696D0 (en) * 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
GB0017518D0 (en) 2000-07-17 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
US6960584B2 (en) 2001-04-10 2005-11-01 Merck & Co., Inc. Inhibitors of Akt activity
US6958334B2 (en) 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
WO2002083064A2 (en) * 2001-04-10 2002-10-24 Merck & Co., Inc. A method of treating cancer
GB0122696D0 (en) * 2001-09-20 2001-11-14 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
WO2003084473A2 (en) * 2002-04-08 2003-10-16 Merck & Co., Inc. Method of treating cancer
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
EP1532120B1 (de) * 2002-08-13 2009-01-14 MERCK SHARP & DOHME LTD. Phenylpyridazin derivative als liganden für gaba-rezeptoren
ATE473980T1 (de) * 2002-12-18 2010-07-15 Vertex Pharma Triazolopyridazine als proteinkinase-inhibitoren
CA2550375A1 (en) 2003-12-19 2005-07-14 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
KR101368093B1 (ko) 2004-09-02 2014-03-14 다케다 게엠베하 트리아졸로프탈라진
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
WO2006072615A2 (en) 2005-01-05 2006-07-13 Nycomed Gmbh Triazolophthalazines as pde2-inhibitors
ES2397082T3 (es) 2005-01-05 2013-03-04 Nycomed Gmbh Triazoloftalazinas como inhibidores de PDE2
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CA2693169C (en) * 2007-07-19 2016-01-12 Metabolex, Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
CN102046627B (zh) * 2008-04-04 2013-09-04 瑞典创新专利公司 Gabaa受体调节剂
EP2328414B1 (de) * 2008-08-29 2013-12-11 Concert Pharmaceuticals Inc. Substituierte triazolo-pyridazin-derivate
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (de) 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modifizierte triazolpyridinderivate als gaba-rezeptormodulatoren
CN102666553B (zh) 2009-10-01 2015-05-06 赛马拜制药公司 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
CN104768554B (zh) * 2012-11-07 2018-04-17 霍夫曼-拉罗奇有限公司 三唑并化合物
AU2017213154B2 (en) 2016-01-27 2023-02-02 Universität Zürich Use of GABAA receptor modulators for treatment of itch
CN107344938B (zh) * 2016-05-06 2022-05-06 上海赛默罗生物科技有限公司 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
JP2019527693A (ja) 2016-08-03 2019-10-03 サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物
EP3796907A4 (de) 2018-05-22 2021-11-03 Neurocycle Therapeutics, Inc. Gabaa-positive allosterische modulatorverbindungen zur behandlung von jucken und/oder dermatitis
BR112022007648A2 (pt) * 2019-10-23 2022-10-11 Neurocycle Therapeutics Inc Tratamento de condições epilépticas com moduladores do receptor gabaa
WO2023150377A1 (en) * 2022-02-07 2023-08-10 The Regents Of The University Of Colorado, A Body Corporate Small molecule cxcr4 agonists, method of synthesis, and method of use
CN120172921A (zh) * 2022-04-15 2025-06-20 内蒙古京科医药科技有限公司 一种1-甲基-1,2,4-三氮唑-3-甲醇及其制备方法
CN114591352B (zh) * 2022-05-11 2022-09-09 上海赛默罗生物科技有限公司 一种三唑并哒嗪类化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
PH21834A (en) 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4578464A (en) * 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9321162D0 (en) 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
GB9507348D0 (en) * 1995-04-08 1995-05-31 Knoll Ag Therapeutic agents
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use

Also Published As

Publication number Publication date
PL331072A1 (en) 1999-06-21
SK9399A3 (en) 2000-04-10
IL127911A0 (en) 1999-11-30
EE9900027A (et) 1999-08-16
HUP0600527A2 (en) 2006-11-28
NZ333768A (en) 2000-09-29
IS4949A (is) 1999-01-19
NO990304D0 (no) 1999-01-22
JP4216905B2 (ja) 2009-01-28
WO1998004559A2 (en) 1998-02-05
JP2002514169A (ja) 2002-05-14
EP0915875B1 (de) 2003-04-09
EA002436B1 (ru) 2002-04-25
EP0915875A2 (de) 1999-05-19
CN1251589A (zh) 2000-04-26
US6255305B1 (en) 2001-07-03
TR199900047T2 (xx) 1999-03-22
BG103112A (en) 1999-09-30
DE69720732D1 (de) 2003-05-15
AU723098B2 (en) 2000-08-17
CZ18199A3 (cs) 1999-06-16
AU3553997A (en) 1998-02-20
KR20000029548A (ko) 2000-05-25
DE69720732T2 (de) 2004-01-29
EA199900164A1 (ru) 2000-04-24
NO990304L (no) 1999-03-25
ES2194205T3 (es) 2003-11-16
BR9710729A (pt) 1999-08-17
YU2899A (sh) 2000-03-21

Similar Documents

Publication Publication Date Title
DE69720732D1 (de) Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren
ATE234323T1 (de) N6-heterocyclisch substituierte adenosin-derivate
AR006390A1 (es) Derivados de lactama
NO20000935D0 (no) Fremgangsmåte for inhibering av komplementaktivering via den alternative reaksjonsvei
DE59711733D1 (de) 3-thiocarbamoylpyrazol-derivate als pestiziden
DE69602638D1 (de) Naphthylverbindungen, Zwischenprodukte, Zusammensetzungen und Methoden
TR199800011T1 (xx) Benzo$g] kuinolin t�revleri
DE69807074D1 (de) Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
ES2145915T3 (es) Derivados estereoquimicos de la wortmannina.
ATE297928T1 (de) Verbesserte verfahren zur herstellung von vernetzt verbrückten macropolycyclen
MA26504A1 (fr) Derives benzimidazole.
ATE216999T1 (de) Pyrimidin-4-on derivate als pestizidesmittel
TR199901057T2 (de)
NO975293D0 (no) Fremgangsmåte for mottaking, samt mottaker
EA199800867A1 (ru) Соединения тетрагидробетакарболина
ATE273307T1 (de) Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren
DE69628458D1 (de) 25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
DE3873278D1 (de) Aryl-substituierte thiophen-3-ole, ihre derivate und analoge als lipoxygenase-inhibitoren.
TR199701613T1 (xx) Selim prostatik hiperplasyan�n tedavisi i�in melatonin agonistleri.
DE59701008D1 (de) Polymere von 2,7-dioxa-bicyclo 3.2.1]octanderivaten
EA199800597A1 (ru) Производные морфина с анальгетической активностью
BG102318A (en) Epoxy-azetidinons, their preparation and application
NO994180D0 (no) Fremgangsmåte for mottaking, samt mottaker

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties