ES2194205T3 - Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba. - Google Patents
Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.Info
- Publication number
- ES2194205T3 ES2194205T3 ES97931960T ES97931960T ES2194205T3 ES 2194205 T3 ES2194205 T3 ES 2194205T3 ES 97931960 T ES97931960 T ES 97931960T ES 97931960 T ES97931960 T ES 97931960T ES 2194205 T3 ES2194205 T3 ES 2194205T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- triazolo
- substituted
- piridazina
- ligandos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA CLASE DE DERIVADOS DE LA 1,2,4 - TRIAZOLO [4,3 - B] PIRIDAZINA SUSTITUIDOS O UNIDOS A ANILLOS 7,8. DICHOS DERIVADOS POSEEN UN SUSTITUYENTE HETEROARILO, FENILO O CICLOALQUILO SUSTITUIDO OPCIONALMENTE EN LA POSICION 3 Y UNA FRACCION ALCOXI SUSTITUIDA EN LA POSICION 6. DICHOS DERIVADOS SON LIGANDOS SELECTIVOS PARA LOS RECEPTORES GABA A , EN PARTICULAR, POSEEN ALTA AFINIDAD POR LAS SUBUNI DADES AL 2 Y/O AL 3 DE DICHOS RECEPTORES. DICHOS DERIVADOS SON POR CONSIGUIENTE UTILES EN EL TRATAMIENTO Y/O PREVENCION DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, INCLUYENDO LA ANSIEDAD Y LAS CONVULSIONES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9615645.0A GB9615645D0 (en) | 1996-07-25 | 1996-07-25 | Therapeutic agents |
GBGB9625397.6A GB9625397D0 (en) | 1996-12-06 | 1996-12-06 | Therapeutic agents |
GBGB9714420.8A GB9714420D0 (en) | 1997-07-09 | 1997-07-09 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194205T3 true ES2194205T3 (es) | 2003-11-16 |
Family
ID=27268403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97931960T Expired - Lifetime ES2194205T3 (es) | 1996-07-25 | 1997-07-17 | Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba. |
Country Status (24)
Country | Link |
---|---|
US (1) | US6255305B1 (es) |
EP (1) | EP0915875B1 (es) |
JP (1) | JP4216905B2 (es) |
KR (1) | KR20000029548A (es) |
CN (1) | CN1251589A (es) |
AT (1) | ATE236904T1 (es) |
AU (1) | AU723098B2 (es) |
BG (1) | BG103112A (es) |
BR (1) | BR9710729A (es) |
CZ (1) | CZ18199A3 (es) |
DE (1) | DE69720732T2 (es) |
EA (1) | EA002436B1 (es) |
EE (1) | EE9900027A (es) |
ES (1) | ES2194205T3 (es) |
HU (1) | HUP0600527A2 (es) |
IL (1) | IL127911A0 (es) |
IS (1) | IS4949A (es) |
NO (1) | NO990304L (es) |
NZ (1) | NZ333768A (es) |
PL (1) | PL331072A1 (es) |
SK (1) | SK9399A3 (es) |
TR (1) | TR199900047T2 (es) |
WO (1) | WO1998004559A2 (es) |
YU (1) | YU2899A (es) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69807074T2 (de) * | 1997-05-08 | 2003-04-03 | Merck Sharp & Dohme | Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden |
GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
GB9718254D0 (en) | 1997-08-28 | 1997-11-05 | Merck Sharp & Dohme | Therapeutic agents |
US6297235B1 (en) * | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
AU1041599A (en) * | 1997-11-13 | 1999-06-07 | Jose Luis Castro Pineiro | Therapeutic uses of triazolo-pyridazine derivatives |
GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
JP2002509150A (ja) * | 1998-01-14 | 2002-03-26 | メルク シャープ エンド ドーム リミテッド | Gaba受容体のリガンドとしてのトリアゾロピリダジン誘導体 |
GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801202D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801210D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
YU43800A (sh) * | 1998-01-21 | 2002-12-10 | Merck Sharp & Dohme Limited | Triazolo-piridazin derivati kao ligandi za gaba receptore |
GB9801397D0 (en) * | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801538D0 (en) * | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
GB9813006D0 (en) | 1998-06-16 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic agents |
EP1087968A1 (en) * | 1998-06-16 | 2001-04-04 | MERCK SHARP & DOHME LTD. | Triazolo-pyridine derivatives as ligands for gaba receptors |
GB9813576D0 (en) * | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
GB9821179D0 (en) * | 1998-09-30 | 1998-11-25 | Merck Sharp & Dohme | Therapeutic use |
WO2000020417A1 (fr) * | 1998-10-06 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Composes de pyridazine condenses, leur procede de preparation et leur utilisation |
AU760688B2 (en) | 1998-10-16 | 2003-05-22 | Merck Sharp & Dohme Limited | Pyrazolo-triazine derivatives as ligands for GABA receptors |
IT1303272B1 (it) | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
GB9824897D0 (en) * | 1998-11-12 | 1999-01-06 | Merck Sharp & Dohme | Therapeutic compounds |
GB2345443A (en) * | 1999-01-08 | 2000-07-12 | Merck Sharp & Dohme | Use of triazolo-pyridazines for treating premenstrual syndrome |
US6500828B1 (en) * | 1999-01-27 | 2002-12-31 | Merck Sharp & Dohme Ltd. | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9903119D0 (en) * | 1999-02-11 | 1999-04-07 | Merck Sharp & Dohme | Therapeutic agents |
US6737242B1 (en) | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
GB9919957D0 (en) * | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
GB9921351D0 (en) * | 1999-09-09 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
US6355638B1 (en) * | 1999-11-25 | 2002-03-12 | Merck Sharp & Dohme Ltd. | Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition |
GB9929569D0 (en) | 1999-12-14 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB9929687D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB9929685D0 (en) * | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB0000564D0 (en) | 2000-01-11 | 2000-03-01 | Merck Sharp & Dohme | Therapeutic agents |
GB0008696D0 (en) * | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
GB0017518D0 (en) * | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
GB0028583D0 (en) | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
AU2002251266A1 (en) * | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
WO2002083140A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
WO2002083139A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
AU2002307163B2 (en) * | 2001-04-10 | 2006-06-29 | Merck & Co., Inc. | A method of treating cancer |
GB0122696D0 (en) | 2001-09-20 | 2001-11-14 | Merck Sharp & Dohme | Therapeutic agents |
GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
EP1496981A2 (en) * | 2002-04-08 | 2005-01-19 | Merck & Co., Inc. | Method of treating cancer |
CA2495285A1 (en) * | 2002-08-13 | 2004-02-19 | Merck Sharp & Dohme Limited | Phenylpyridazine derivatives as ligands for gaba receptors |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
US7268136B2 (en) * | 2002-12-18 | 2007-09-11 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
PL1697371T3 (pl) | 2003-12-19 | 2007-09-28 | Bristol Myers Squibb Co | Azabicykliczne heterocykle jako modulatory receptora kanabinoidowego |
DE602005021894D1 (de) * | 2004-09-02 | 2010-07-29 | Nycomed Gmbh | Triazolophthalazine |
WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
US7671050B2 (en) | 2005-01-05 | 2010-03-02 | Nycomed Gmbh | Triazolophthalazines |
ES2397080T3 (es) | 2005-01-05 | 2013-03-04 | Nycomed Gmbh | Triazoloftalazinas como agentes inhibidores de la PDE2 |
US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
KR20100033419A (ko) * | 2007-07-19 | 2010-03-29 | 메타볼렉스, 인코포레이티드 | 당뇨병 및 대사 장애의 치료를 위한 rup3 또는 gpr119 수용체의 작용제로서 n-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체 |
EP2288612B1 (en) * | 2008-04-04 | 2015-07-29 | Gabather AB | Gabaa receptor modulators |
ES2451542T3 (es) | 2008-08-29 | 2014-03-27 | Concert Pharmaceuticals Inc. | Derivados de triazolo-piridazina sustituidos |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011005520A1 (en) | 2009-06-23 | 2011-01-13 | Concert Pharmaceuticals, Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス, インコーポレーテッド | 置換テトラゾール−1−イルフェノキシメチルチアゾール−2−イルピペリジニルピリミジン塩 |
US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
CN102791715B (zh) | 2009-12-31 | 2016-04-27 | 卡洛斯三世国家癌症研究中心基金会 | 用作激酶抑制剂的三环化合物 |
WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
WO2013005057A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | New compounds |
WO2013005041A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Tricyclic heterocyclic compounds as kinase inhibitors |
WO2013004984A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Tricyclic compounds for use as kinase inhibitors |
ES2603931T3 (es) * | 2012-11-07 | 2017-03-02 | F. Hoffmann-La Roche Ag | Compuestos de triazolo |
EP3407886A1 (en) * | 2016-01-27 | 2018-12-05 | Universität Zürich | Use of gabaa receptor modulators for treatment of itch |
CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
CN107344938B (zh) * | 2016-05-06 | 2022-05-06 | 上海赛默罗生物科技有限公司 | 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途 |
CN109862896A (zh) | 2016-08-03 | 2019-06-07 | 西玛贝医药公司 | 用于治疗炎症性胃肠疾病或胃肠病症的氧亚甲基芳基化合物 |
WO2019226820A1 (en) | 2018-05-22 | 2019-11-28 | Neurocycle Therapeutics, Inc. | Gabaa positive allosteric modulator compounds for treatment of itch and/ or dermatitis |
AU2020369597A1 (en) * | 2019-10-23 | 2022-05-12 | Neurocycle Therapeutics, Inc. | Treatment of epileptic conditions with GABAA receptor modulators |
WO2023150377A1 (en) * | 2022-02-07 | 2023-08-10 | The Regents Of The University Of Colorado, A Body Corporate | Small molecule cxcr4 agonists, method of synthesis, and method of use |
CN114591352B (zh) * | 2022-05-11 | 2022-09-09 | 上海赛默罗生物科技有限公司 | 一种三唑并哒嗪类化合物及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1080712A (en) | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
FI81350C (fi) * | 1982-01-18 | 1990-10-10 | Lepetit Spa | Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. |
US4487930A (en) | 1982-09-07 | 1984-12-11 | The Dow Chemical Company | 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines |
IT1194310B (it) | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
US4578464A (en) | 1983-11-22 | 1986-03-25 | Merrell Dow Pharmaceuticals Inc. | 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds |
FR2562071B1 (fr) * | 1984-03-30 | 1986-12-19 | Sanofi Sa | Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
GB9321162D0 (en) | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
GB9507348D0 (en) * | 1995-04-08 | 1995-05-31 | Knoll Ag | Therapeutic agents |
GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
-
1997
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Application Discontinuation
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en active IP Right Grant
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
-
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EE9900027A (et) | 1999-08-16 |
YU2899A (sh) | 2000-03-21 |
AU723098B2 (en) | 2000-08-17 |
JP4216905B2 (ja) | 2009-01-28 |
NO990304D0 (no) | 1999-01-22 |
IL127911A0 (en) | 1999-11-30 |
KR20000029548A (ko) | 2000-05-25 |
ATE236904T1 (de) | 2003-04-15 |
CN1251589A (zh) | 2000-04-26 |
EP0915875B1 (en) | 2003-04-09 |
EA199900164A1 (ru) | 2000-04-24 |
SK9399A3 (en) | 2000-04-10 |
WO1998004559A2 (en) | 1998-02-05 |
NZ333768A (en) | 2000-09-29 |
BG103112A (en) | 1999-09-30 |
DE69720732D1 (de) | 2003-05-15 |
EP0915875A2 (en) | 1999-05-19 |
EA002436B1 (ru) | 2002-04-25 |
AU3553997A (en) | 1998-02-20 |
DE69720732T2 (de) | 2004-01-29 |
HUP0600527A2 (en) | 2006-11-28 |
US6255305B1 (en) | 2001-07-03 |
IS4949A (is) | 1999-01-19 |
NO990304L (no) | 1999-03-25 |
JP2002514169A (ja) | 2002-05-14 |
TR199900047T2 (xx) | 1999-03-22 |
PL331072A1 (en) | 1999-06-21 |
BR9710729A (pt) | 1999-08-17 |
CZ18199A3 (cs) | 1999-06-16 |
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---|---|---|
ES2194205T3 (es) | Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba. | |
ES2151652T3 (es) | Derivados de indol como antagonistas del receptor 5ht. | |
PA8510001A1 (es) | Antagonistas del factor liberador de corticotropina | |
ES2101063T3 (es) | Derivados monofluorados de n-propargil-1-amino-indano y su utilizacion como inhibidores de la monoamin-oxidasa. | |
ES2188793T3 (es) | Agente para el tratamiento de las enfermedades neurodegenerativas. | |
HN2001000192A (es) | Derivados de pirazol | |
ES2076303T3 (es) | Derivados de decahidro isoquinoleina, procedimiento para su preparacion y su uso como medicinas. | |
MX9305294A (es) | Compuestos de decahidroisoquinolina, procedimiento para su preparacion y formulacion farmaceutica que los comprende. | |
PA8468501A1 (es) | Compuestos heterociclicos como inhibidores de enzimas rotamasas | |
AR002289A1 (es) | Derivados de acetamida, procedimiento para prepararlos, las composiciones farmaceuticas que los contienen y las aplicaciones de dichos compuestos comoansioliticos y en el tratamiento de enfermedades inmuno-inflamatorias. | |
GT199900146A (es) | Derivados de 4,4-biarilpiperidina. | |
SV1998000029A (es) | Compuestos de pirazina ref. pg3186 | |
ES2159760T3 (es) | Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina. | |
ES2132223T3 (es) | Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4. | |
PA8457001A1 (es) | Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol | |
ES2175386T3 (es) | Derivados de 2,3-benzodiazepina y su utilizacion como inhibidores de receptores de ampa. | |
UY27232A1 (es) | Nuevos compuestos de dihidropirimidina ciano substituidos y su uso para tratar padecimientos | |
EA200100071A1 (ru) | Замещенное производное триазоло-пиридазина, фармацевтические композиции, приготовленные на его основе | |
ES2149504T3 (es) | Imidazo(1,2-a)quinoxalin-4-aminas activas como antagonistas de la adenosina, procedimiento para su preparacion y composiciones farmaceuticas de las mismas. | |
UY27998A1 (es) | Piperazinas sustituidas sustituidas heterocíclicas para el tratamiento de la esquizofrenia | |
DE69824195D1 (de) | Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems | |
ES2057341T3 (es) | Ciclohexenos substituidos como agentes para el sistema nervioso central. | |
ES2167721T3 (es) | Utilizacion de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica. | |
ES2156889T3 (es) | Compuestos biciclicos antagonistas de receptores de aminoacidos excitativos. | |
ES2162686T3 (es) | Nuevos derivados carboxamidas ciclicos sustituidos por carboxi. |