DE69720732T2 - Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren - Google Patents
Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren Download PDFInfo
- Publication number
- DE69720732T2 DE69720732T2 DE69720732T DE69720732T DE69720732T2 DE 69720732 T2 DE69720732 T2 DE 69720732T2 DE 69720732 T DE69720732 T DE 69720732T DE 69720732 T DE69720732 T DE 69720732T DE 69720732 T2 DE69720732 T2 DE 69720732T2
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- pyridazine derivatives
- gaba receptors
- substituted triazolo
- triazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- -1 triazolo-pyridazine derivative compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9615645.0A GB9615645D0 (en) | 1996-07-25 | 1996-07-25 | Therapeutic agents |
GBGB9625397.6A GB9625397D0 (en) | 1996-12-06 | 1996-12-06 | Therapeutic agents |
GBGB9714420.8A GB9714420D0 (en) | 1997-07-09 | 1997-07-09 | Therapeutic agents |
PCT/GB1997/001946 WO1998004559A2 (en) | 1996-07-25 | 1997-07-17 | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69720732D1 DE69720732D1 (de) | 2003-05-15 |
DE69720732T2 true DE69720732T2 (de) | 2004-01-29 |
Family
ID=27268403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69720732T Expired - Lifetime DE69720732T2 (de) | 1996-07-25 | 1997-07-17 | Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren |
Country Status (24)
Country | Link |
---|---|
US (1) | US6255305B1 (de) |
EP (1) | EP0915875B1 (de) |
JP (1) | JP4216905B2 (de) |
KR (1) | KR20000029548A (de) |
CN (1) | CN1251589A (de) |
AT (1) | ATE236904T1 (de) |
AU (1) | AU723098B2 (de) |
BG (1) | BG103112A (de) |
BR (1) | BR9710729A (de) |
CZ (1) | CZ18199A3 (de) |
DE (1) | DE69720732T2 (de) |
EA (1) | EA002436B1 (de) |
EE (1) | EE9900027A (de) |
ES (1) | ES2194205T3 (de) |
HU (1) | HUP0600527A2 (de) |
IL (1) | IL127911A0 (de) |
IS (1) | IS4949A (de) |
NO (1) | NO990304L (de) |
NZ (1) | NZ333768A (de) |
PL (1) | PL331072A1 (de) |
SK (1) | SK9399A3 (de) |
TR (1) | TR199900047T2 (de) |
WO (1) | WO1998004559A2 (de) |
YU (1) | YU2899A (de) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE221887T1 (de) | 1997-05-08 | 2002-08-15 | Merck Sharp & Dohme | Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden |
GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
GB9718254D0 (en) | 1997-08-28 | 1997-11-05 | Merck Sharp & Dohme | Therapeutic agents |
US6297235B1 (en) * | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
AU1041599A (en) * | 1997-11-13 | 1999-06-07 | Jose Luis Castro Pineiro | Therapeutic uses of triazolo-pyridazine derivatives |
GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
CA2315219A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
WO1999037644A1 (en) * | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9801202D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801210D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801208D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801397D0 (en) * | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
GB9801538D0 (en) * | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
GB9813006D0 (en) * | 1998-06-16 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic agents |
CA2334836A1 (en) * | 1998-06-16 | 1999-12-23 | Merck Sharp & Dohme Limited | Triazolo-pyridine derivatives as ligands for gaba receptors |
GB9813576D0 (en) * | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
GB9821179D0 (en) * | 1998-09-30 | 1998-11-25 | Merck Sharp & Dohme | Therapeutic use |
AU6003099A (en) * | 1998-10-06 | 2000-04-26 | Takeda Chemical Industries Ltd. | Fused pyridazine compounds, process for the preparation of the same and uses thereof |
DE69936998T2 (de) | 1998-10-16 | 2008-05-21 | Merck Sharp & Dohme Ltd., Hoddesdon | Pyrazolotriazinderivate als gaba-rezeptorliganden |
IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
GB9824897D0 (en) * | 1998-11-12 | 1999-01-06 | Merck Sharp & Dohme | Therapeutic compounds |
GB2345443A (en) * | 1999-01-08 | 2000-07-12 | Merck Sharp & Dohme | Use of triazolo-pyridazines for treating premenstrual syndrome |
CA2359008C (en) * | 1999-01-27 | 2008-05-20 | William Robert Carling | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9903119D0 (en) * | 1999-02-11 | 1999-04-07 | Merck Sharp & Dohme | Therapeutic agents |
US6737242B1 (en) | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
GB9919957D0 (en) | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
GB9921351D0 (en) * | 1999-09-09 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
US6355638B1 (en) * | 1999-11-25 | 2002-03-12 | Merck Sharp & Dohme Ltd. | Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition |
GB9929569D0 (en) * | 1999-12-14 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB9929687D0 (en) * | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB9929685D0 (en) * | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB0000564D0 (en) | 2000-01-11 | 2000-03-01 | Merck Sharp & Dohme | Therapeutic agents |
GB0008696D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
GB0017518D0 (en) | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
GB0018473D0 (en) * | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
GB0028583D0 (en) | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
AU2002251266A1 (en) * | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
WO2002083139A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
WO2002083140A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
JP2004527531A (ja) * | 2001-04-10 | 2004-09-09 | メルク エンド カムパニー インコーポレーテッド | 癌を治療する方法 |
GB0122696D0 (en) | 2001-09-20 | 2001-11-14 | Merck Sharp & Dohme | Therapeutic agents |
GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
EP1496981A2 (de) * | 2002-04-08 | 2005-01-19 | Merck & Co., Inc. | Verfahren zur behandlung von krebs |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
US20060235021A1 (en) * | 2002-08-13 | 2006-10-19 | Wesley Blackaby | Phenylpyridazine derivatives as ligands for gaba receptors |
AU2003297161B8 (en) | 2002-12-18 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
KR20060103265A (ko) * | 2003-12-19 | 2006-09-28 | 브리스톨-마이어스 스큅 컴퍼니 | 카나비노이드 수용체 조절제인 아자비시클릭 헤테로사이클 |
AU2005279221C9 (en) * | 2004-09-02 | 2012-08-23 | Takeda Gmbh | Triazolophthalazines |
WO2006061428A2 (en) * | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
CN101103033B (zh) | 2005-01-05 | 2010-08-04 | 尼科梅德有限责任公司 | 作为pde2抑制剂的三唑并酞嗪 |
JP5130053B2 (ja) | 2005-01-05 | 2013-01-30 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアゾロフタラジン |
US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
EP2275095A3 (de) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
BRPI0814294A2 (pt) | 2007-07-19 | 2015-02-03 | Metabolex Inc | Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas. |
CA2720464C (en) * | 2008-04-04 | 2017-05-02 | Forskarpatent I Syd Ab | Gabaa receptor modulators |
EA020071B1 (ru) | 2008-08-29 | 2014-08-29 | Консерт Фармасьютикалс Инк. | Замещенные производные триазолопиридазина |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
JP2012531419A (ja) | 2009-06-23 | 2012-12-10 | コンサート ファーマシューティカルズ インコーポレイテッド | Gaba−a受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体 |
WO2011041154A1 (en) | 2009-10-01 | 2011-04-07 | Metabolex, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
CN102791715B (zh) | 2009-12-31 | 2016-04-27 | 卡洛斯三世国家癌症研究中心基金会 | 用作激酶抑制剂的三环化合物 |
WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
WO2013004984A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Tricyclic compounds for use as kinase inhibitors |
WO2013005057A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | New compounds |
WO2013005041A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Tricyclic heterocyclic compounds as kinase inhibitors |
EP2916842B1 (de) * | 2012-11-07 | 2016-10-19 | F. Hoffmann-La Roche AG | Triazolo-verbindungen |
CN108697694B (zh) * | 2016-01-27 | 2022-12-09 | 苏黎世大学 | Gabaa受体调节剂用于治疗发痒的用途 |
CN107344938B (zh) * | 2016-05-06 | 2022-05-06 | 上海赛默罗生物科技有限公司 | 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途 |
CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
KR20190035752A (ko) | 2016-08-03 | 2019-04-03 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 염증성 위장 질환 또는 위장 상태를 치료하기 위한 옥시메틸렌 아릴 화합물 |
EP3796907A4 (de) | 2018-05-22 | 2021-11-03 | Neurocycle Therapeutics, Inc. | Gabaa-positive allosterische modulatorverbindungen zur behandlung von jucken und/oder dermatitis |
IL292343A (en) * | 2019-10-23 | 2022-06-01 | Neurocycle Therapeutics Inc | Treatment of epileptic states with gabaa receptor modulators |
WO2023150377A1 (en) * | 2022-02-07 | 2023-08-10 | The Regents Of The University Of Colorado, A Body Corporate | Small molecule cxcr4 agonists, method of synthesis, and method of use |
CN114591352B (zh) * | 2022-05-11 | 2022-09-09 | 上海赛默罗生物科技有限公司 | 一种三唑并哒嗪类化合物及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
PH21834A (en) * | 1982-01-18 | 1988-03-17 | Lepetit Spa | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives |
US4487930A (en) | 1982-09-07 | 1984-12-11 | The Dow Chemical Company | 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines |
IT1194310B (it) | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
US4578464A (en) | 1983-11-22 | 1986-03-25 | Merrell Dow Pharmaceuticals Inc. | 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds |
FR2562071B1 (fr) * | 1984-03-30 | 1986-12-19 | Sanofi Sa | Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
GB9321162D0 (en) * | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
GB9507348D0 (en) * | 1995-04-08 | 1995-05-31 | Knoll Ag | Therapeutic agents |
GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
-
1997
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 EP EP97931960A patent/EP0915875B1/de not_active Expired - Lifetime
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en active IP Right Grant
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Application Discontinuation
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
-
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO990304L (no) | 1999-03-25 |
KR20000029548A (ko) | 2000-05-25 |
TR199900047T2 (xx) | 1999-03-22 |
EA002436B1 (ru) | 2002-04-25 |
ES2194205T3 (es) | 2003-11-16 |
EE9900027A (et) | 1999-08-16 |
YU2899A (sh) | 2000-03-21 |
JP2002514169A (ja) | 2002-05-14 |
BG103112A (en) | 1999-09-30 |
CN1251589A (zh) | 2000-04-26 |
IS4949A (is) | 1999-01-19 |
WO1998004559A2 (en) | 1998-02-05 |
SK9399A3 (en) | 2000-04-10 |
BR9710729A (pt) | 1999-08-17 |
US6255305B1 (en) | 2001-07-03 |
AU723098B2 (en) | 2000-08-17 |
AU3553997A (en) | 1998-02-20 |
ATE236904T1 (de) | 2003-04-15 |
NZ333768A (en) | 2000-09-29 |
IL127911A0 (en) | 1999-11-30 |
EP0915875B1 (de) | 2003-04-09 |
CZ18199A3 (cs) | 1999-06-16 |
NO990304D0 (no) | 1999-01-22 |
PL331072A1 (en) | 1999-06-21 |
HUP0600527A2 (en) | 2006-11-28 |
DE69720732D1 (de) | 2003-05-15 |
EP0915875A2 (de) | 1999-05-19 |
EA199900164A1 (ru) | 2000-04-24 |
JP4216905B2 (ja) | 2009-01-28 |
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