ATE221887T1 - Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden - Google Patents

Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden

Info

Publication number
ATE221887T1
ATE221887T1 AT98920635T AT98920635T ATE221887T1 AT E221887 T1 ATE221887 T1 AT E221887T1 AT 98920635 T AT98920635 T AT 98920635T AT 98920635 T AT98920635 T AT 98920635T AT E221887 T1 ATE221887 T1 AT E221887T1
Authority
AT
Austria
Prior art keywords
triazolo
ligands
substituted
gaba
alpha
Prior art date
Application number
AT98920635T
Other languages
English (en)
Inventor
William Robert Carling
Tamara Ladduwahetty
Angus Murray Macleod
Kevin John Merchant
Kevin William Moore
Francine Sternfeld
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9709368.6A external-priority patent/GB9709368D0/en
Priority claimed from GBGB9714508.0A external-priority patent/GB9714508D0/en
Priority claimed from GBGB9723741.6A external-priority patent/GB9723741D0/en
Priority claimed from GBGB9803992.8A external-priority patent/GB9803992D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE221887T1 publication Critical patent/ATE221887T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT98920635T 1997-05-08 1998-05-06 Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden ATE221887T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9709368.6A GB9709368D0 (en) 1997-05-08 1997-05-08 GABA-A Alpha 5 selective inverse agonists for cognition enhancement
GBGB9714508.0A GB9714508D0 (en) 1997-07-10 1997-07-10 Therapeutic agents
GBGB9723741.6A GB9723741D0 (en) 1997-11-11 1997-11-11 Therapeutic agents
GBGB9803992.8A GB9803992D0 (en) 1998-02-25 1998-02-25 Therapeutic agents
PCT/GB1998/001307 WO1998050385A1 (en) 1997-05-08 1998-05-06 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS

Publications (1)

Publication Number Publication Date
ATE221887T1 true ATE221887T1 (de) 2002-08-15

Family

ID=27451643

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98920635T ATE221887T1 (de) 1997-05-08 1998-05-06 Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden

Country Status (9)

Country Link
US (2) US6200975B1 (de)
EP (1) EP0986562B1 (de)
JP (1) JP4672820B2 (de)
AT (1) ATE221887T1 (de)
AU (1) AU732455C (de)
CA (1) CA2288789C (de)
DE (1) DE69807074T2 (de)
ES (1) ES2179490T3 (de)
WO (1) WO1998050385A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2288789C (en) 1997-05-08 2009-07-21 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9718254D0 (en) * 1997-08-28 1997-11-05 Merck Sharp & Dohme Therapeutic agents
EP1047697A1 (de) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazin-derivate als liganden für gaba-rezeptoren
WO1999043677A1 (en) * 1998-02-25 1999-09-02 Merck Sharp & Dohme Limited SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PYRIDAZINE
CZ291302B6 (cs) 1998-02-25 2003-01-15 Merck Sharp & Dohme Limited Substituovaný 1,2,4-triazolo[3,4-a]ftalazinový derivát
GB9805557D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
GB9824897D0 (en) * 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
AU1816900A (en) * 1998-11-12 2000-05-29 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
US6440967B1 (en) * 1998-11-12 2002-08-27 Merck & Co., Inc. Combination of a GABAA alpha 5 inverse agonist and COX-2 inhibitor, NSAID, estrogen or vitamin E
WO2000027382A2 (en) * 1998-11-12 2000-05-18 Merck & Co., Inc. Combination of a gaba-a alpha 5 inverse agonist and cox-2 inhibitor, nsaid, estrogen or vitamin e
GB9911804D0 (en) * 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
GB9911802D0 (en) * 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
GB9911803D0 (en) * 1999-05-20 1999-07-21 Merck Sharp & Dohme Therapeutic combination
CA2389280C (en) * 1999-11-15 2009-01-27 Janssen Pharmaceutica N.V. Triazoles as farnesyl transferase inhibitors
GB9929569D0 (en) 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
US6528649B2 (en) 2000-05-30 2003-03-04 Neurogen Corporation Imidazoloisoquinolines
US6653471B2 (en) 2000-08-07 2003-11-25 Neurogen Corporation Heterocyclic compounds as ligands of the GABAA receptor
GB0028583D0 (en) * 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
KR101368093B1 (ko) 2004-09-02 2014-03-14 다케다 게엠베하 트리아졸로프탈라진
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
ES2397082T3 (es) 2005-01-05 2013-03-04 Nycomed Gmbh Triazoloftalazinas como inhibidores de PDE2
WO2006072615A2 (en) 2005-01-05 2006-07-13 Nycomed Gmbh Triazolophthalazines as pde2-inhibitors
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2008035726A1 (en) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
EP2226320A4 (de) * 2007-12-26 2012-07-11 Eisai R&D Man Co Ltd Herstellungsverfahren für heterocyclus-substituiertes pyridinderivat
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011020044A1 (en) * 2009-08-14 2011-02-17 Concert Pharmaceuticals, Inc. Substituted triazolophthalazine derivatives
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
ES2603032T3 (es) 2010-07-15 2017-02-23 Bayer Intellectual Property Gmbh Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas
US20150374705A1 (en) * 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN106854207B (zh) 2015-12-08 2019-10-29 上海赛默罗生物科技有限公司 呔嗪类衍生物、其制备方法、药物组合物和用途
CN110256440B (zh) * 2018-03-12 2023-05-23 上海赛默罗生物科技有限公司 酞嗪异噁唑烷氧基衍生物、其制备方法、药物组合物和用途
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators
CN112279802B (zh) * 2020-10-12 2022-03-08 江苏美迪克化学品有限公司 一种2-氯甲基-3-三氟甲基吡啶的制备方法
KR20240005848A (ko) 2021-05-05 2024-01-12 유니버시티 칼리지 카디프 컨설턴츠 리미티드 인지 장애의 치료에 유용한 헤테로아릴 화합물
CN114591352B (zh) * 2022-05-11 2022-09-09 上海赛默罗生物科技有限公司 一种三唑并哒嗪类化合物及其应用
CN114773352B (zh) * 2022-06-20 2023-03-17 上海赛默罗生物科技有限公司 制备取代的烟酰胺的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5182290A (en) 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
US5212310A (en) 1991-12-19 1993-05-18 Neurogen Corporation Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
JPH05229946A (ja) * 1992-02-20 1993-09-07 Sapporo Breweries Ltd トリアゾロフタラジン誘導体を含有する抗潰瘍剤
US5306819A (en) 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
GB9503601D0 (en) 1995-02-23 1995-04-12 Merck Sharp & Dohme Method of treatment and method of manufacture of medicament
DE19617862A1 (de) * 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
EP0915877A1 (de) 1996-07-25 1999-05-19 MERCK SHARP & DOHME LTD. Substituierte triazolo-pyridazinderivate als inverse agonisten des gaba-a alpha-5 rezeptor subtyps
ATE236904T1 (de) * 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren
CA2288789C (en) 1997-05-08 2009-07-21 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands

Also Published As

Publication number Publication date
DE69807074T2 (de) 2003-04-03
AU732455C (en) 2002-09-05
EP0986562A1 (de) 2000-03-22
AU7342898A (en) 1998-11-27
DE69807074D1 (de) 2002-09-12
US6200975B1 (en) 2001-03-13
ES2179490T3 (es) 2003-01-16
US6310203B1 (en) 2001-10-30
JP4672820B2 (ja) 2011-04-20
CA2288789C (en) 2009-07-21
WO1998050385A1 (en) 1998-11-12
CA2288789A1 (en) 1998-11-12
JP2001525802A (ja) 2001-12-11
EP0986562B1 (de) 2002-08-07
AU732455B2 (en) 2001-04-26

Similar Documents

Publication Publication Date Title
ATE221887T1 (de) Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden
BR9808491A (pt) Compostos calcilìticos
TR199901653T2 (xx) Fitalazinonlar.
TR199902400T2 (xx) Fungusit etkinlik g�steren terkiplerin birle�imleri.
ES2184077T3 (es) Nuevas fenantridinas sustituidas en la posicion 6.
DE59709437D1 (de) Neue phenanthridine
BG102616A (en) Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
DE69805643D1 (de) Membrane-elektroden-anordnung
ATE293618T1 (de) 4, 5, 6, 7-tetrahydroindazolderivate als antitumormittel
MX9700486A (es) Ligando para receptor de cinasa transmembranal de hepatoma.
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
IT1285770B1 (it) Composti corticoidei
ID21413A (id) Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
RU95101375A (ru) Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, их получение и применение в терапии
TR199800988A3 (tr) 5' Deoksi-Sitidin türevleri.
FI98970B (fi) Käsipuhelimen lisävahvistinjärjestely
GB2324091A (en) Metalloproteinase inhibitors
TR199701202T1 (xx) Yeni hidroksimik asit t�revleri.
TR199701298T1 (xx) Tetralinler.
HRP20000866B1 (en) A reference compound for use in the analysis of levosimendan batches
DE69610778D1 (de) Pyridiniminyl-1,2-benzisoxazole und- benzisothiazole als antipsychotika
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
DE60003560D1 (de) 1,2-dihydro-1-oxo-pyrazino[1,2-]indolederivate
PT1104419E (pt) Derivados de azabicicloheptano substituidos no azoto sua preparacao e utilizacao
TR199701011A2 (xx) 1-karba-(detia)-sefalosforin t�revleri.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties