MX9700486A - Ligando para receptor de cinasa transmembranal de hepatoma. - Google Patents

Ligando para receptor de cinasa transmembranal de hepatoma.

Info

Publication number
MX9700486A
MX9700486A MX9700486A MX9700486A MX9700486A MX 9700486 A MX9700486 A MX 9700486A MX 9700486 A MX9700486 A MX 9700486A MX 9700486 A MX9700486 A MX 9700486A MX 9700486 A MX9700486 A MX 9700486A
Authority
MX
Mexico
Prior art keywords
htk ligand
htk
ligand
Prior art date
Application number
MX9700486A
Other languages
English (en)
Inventor
Brian D Bennett
William Matthews
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23062090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9700486(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX9700486A publication Critical patent/MX9700486A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Se describe un ligando para receptor de liga transmembranal de hepatoma novedoso (ligando HtK) el cual se une a, y activa al receptor de HtK. Como ejemplos, se han identificado ligandos de HtK de raton y de humano en diversos tejidos utilizando una proteína de fusion soluble HtK-Fc. Los ligandos se han clonado y se han determinado su secuencia. La invencion también se relaciona con ácidos nucleicos que codifican para el ligando, métodos para la produccion y uso del ligando, y anticuerpos dirigidos hacia el mismo.
MX9700486A 1994-07-20 1995-07-14 Ligando para receptor de cinasa transmembranal de hepatoma. MX9700486A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27772294A 1994-07-20 1994-07-20
PCT/US1995/008812 WO1996002645A2 (en) 1994-07-20 1995-07-14 Htk ligand

Publications (1)

Publication Number Publication Date
MX9700486A true MX9700486A (es) 1997-04-30

Family

ID=23062090

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700486A MX9700486A (es) 1994-07-20 1995-07-14 Ligando para receptor de cinasa transmembranal de hepatoma.

Country Status (11)

Country Link
US (2) US5864020A (es)
EP (1) EP0773997B2 (es)
JP (1) JPH10501701A (es)
AT (1) ATE324441T1 (es)
AU (1) AU705107B2 (es)
CA (1) CA2194955A1 (es)
DE (1) DE69534962T3 (es)
ES (1) ES2264127T5 (es)
IL (1) IL114668A (es)
MX (1) MX9700486A (es)
WO (1) WO1996002645A2 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932214A (en) * 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
WO1996026958A2 (en) * 1995-02-27 1996-09-06 President And Fellows Of Harvard College Eph RECEPTOR LIGAND ELF-2
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
US6291210B1 (en) 1996-07-16 2001-09-18 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
AUPO754997A0 (en) * 1997-06-25 1997-07-17 Leukaemia Foundation Of Queensland, The Receptor-ligand system and assay therefor
EP1019080A2 (en) 1997-10-02 2000-07-19 Leukosite, Inc. Modulation of lerk-2-mediated cell adhesion
US6864227B1 (en) 1998-04-13 2005-03-08 California Institute Of Technology Artery-and vein-specific proteins and uses therefor
US6887674B1 (en) 1998-04-13 2005-05-03 California Institute Of Technology Artery- and vein-specific proteins and uses therefor
WO2000030673A1 (en) * 1998-11-20 2000-06-02 Genentech, Inc. Uses for eph receptor antagonists and agonists to treat vascular disorders
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
EP1978110B1 (en) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-based method and system for screening genomic DNA
WO2002026827A1 (en) * 2000-09-29 2002-04-04 Novartis Ag Extracellular polypeptides of eph b receptors and ephrin b ligands and the corresponding nucleic acid molecules
ES2377720T3 (es) * 2002-05-10 2012-03-30 Purdue Research Foundation Anticuerpos monoclonales agon�?sticos epha2 y métodos de uso de los mismos.
US20050152899A1 (en) * 2002-05-10 2005-07-14 Kinch Michael S. EphA2 agonistic monoclonal antibodies and methods of use thereof
US20040028685A1 (en) * 2002-05-10 2004-02-12 Kinch Michael S. EphA2 monoclonal antibodies and methods of use thereof
WO2004012660A2 (en) * 2002-08-02 2004-02-12 Wyeth Mk2 interacting proteins
EP1553963A4 (en) * 2002-09-24 2006-05-03 Burnham Inst NEW MEANS FOR MODULATING EPH RECEPTOR ACTIVITY
US7381410B2 (en) * 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
JP2006521111A (ja) * 2003-03-12 2006-09-21 バスジーン セラピューティクス， インコーポレイテッド 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用
AU2004230539A1 (en) * 2003-04-11 2004-10-28 Medimmune, Llc EphA2, hypoproliferative cell disorders and epithelial and endothelial reconstitution
JP2006524693A (ja) * 2003-04-11 2006-11-02 メディミューン，インコーポレーテッド ＥｐｈＡ２および非腫瘍性過増殖性細胞障害
US7977463B2 (en) * 2004-03-12 2011-07-12 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
CN102718867A (zh) 2004-03-12 2012-10-10 瓦斯基因治疗公司 结合ephb4、抑制血管发生和肿瘤生长的抗体
EP1602928A1 (en) * 2004-06-01 2005-12-07 Universiteit Maastricht Process and kit for determining binding parameters of bioaffinity binding reactions
JP2008514925A (ja) * 2004-09-23 2008-05-08 バスジーン セラピューティクス， インコーポレイテッド 腫瘍を検出し且つ治療するための組成物及び方法
US20060204512A1 (en) * 2004-09-23 2006-09-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
ATE486890T1 (de) * 2005-01-27 2010-11-15 Burnham Inst Ephb-rezeptorbindende peptide
CA2623387A1 (en) * 2005-09-23 2007-04-05 Vasgene Therapeutics, Inc. Use of ephrinb2 directed agents for the treatment or prevention of viral infections
CA2623563A1 (en) * 2005-10-05 2007-04-19 Aqumen Biopharmaceuticals K.K. Method of inhibiting angiogenesis by using ephrin b2
SI1973950T1 (sl) * 2006-01-05 2015-01-30 Genentech, Inc. Anti-EphB4 protitelesa in postopki njihove uporabe
US8975377B2 (en) * 2007-08-13 2015-03-10 Vasgene Therapeutics, Inc Cancer treatment using humanized antibodies that bind to EphB4
EP2697257B1 (en) * 2011-04-13 2016-10-19 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
WO2013065343A1 (ja) * 2011-10-31 2013-05-10 株式会社 島津製作所 非ペプチドヒンジ部含有フレキシブル抗体様分子

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128722A1 (en) * 1992-01-22 1993-08-05 William I. Wood Novel protein tyrosine kinases
US5635177A (en) * 1992-01-22 1997-06-03 Genentech, Inc. Protein tyrosine kinase agonist antibodies
EP0669929B1 (en) * 1992-11-13 2007-01-03 Immunex Corporation Elk ligand, a cytokine
IL113252A0 (en) * 1994-04-04 1995-07-31 Regeneration Pharmaceuticals I Eph receptors binding ligands
US6303769B1 (en) * 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna

Also Published As

Publication number Publication date
DE69534962T2 (de) 2007-02-08
US5864020A (en) 1999-01-26
EP0773997A2 (en) 1997-05-21
IL114668A (en) 2007-07-24
AU3008995A (en) 1996-02-16
CA2194955A1 (en) 1996-02-01
IL114668A0 (en) 1995-11-27
DE69534962T3 (de) 2012-10-04
JPH10501701A (ja) 1998-02-17
ES2264127T3 (es) 2006-12-16
WO1996002645A3 (en) 1996-02-15
AU705107B2 (en) 1999-05-13
ATE324441T1 (de) 2006-05-15
US5624899A (en) 1997-04-29
EP0773997B1 (en) 2006-04-26
EP0773997B2 (en) 2012-04-25
ES2264127T5 (es) 2012-07-04
DE69534962D1 (en) 2006-06-01
WO1996002645A2 (en) 1996-02-01

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