AR079451A1 - Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina - Google Patents
Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolinaInfo
- Publication number
- AR079451A1 AR079451A1 ARP100104617A ARP100104617A AR079451A1 AR 079451 A1 AR079451 A1 AR 079451A1 AR P100104617 A ARP100104617 A AR P100104617A AR P100104617 A ARP100104617 A AR P100104617A AR 079451 A1 AR079451 A1 AR 079451A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkoxy
- isoxazol
- oxazol
- oxadiazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- -1 pyrazol-4-yl Chemical group 0.000 abstract 17
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001359 1,2,3-triazol-4-yl group Chemical group [H]N1N=NC([*])=C1[H] 0.000 abstract 1
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 abstract 1
- 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 abstract 1
- 125000004516 1,2,4-thiadiazol-5-yl group Chemical group S1N=CN=C1* 0.000 abstract 1
- 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 abstract 1
- 125000004509 1,3,4-oxadiazol-2-yl group Chemical group O1C(=NN=C1)* 0.000 abstract 1
- 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 abstract 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 abstract 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 abstract 1
- 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 abstract 1
- 125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
Abstract
Composicion farmacéutica y uso como inhibidores de fosfodiesterasas 4 y 5. Reivindicacion 1: Un compuesto que tiene la formula (1) en donde A es S, S(O) o S(O)2, cualquiera de R1 es alcoxi C1-4, cicloalcoxi C3-7, cicloalquilmetoxi C3-7, o alcoxi C1-4 sustituido en forma predominante o sustituido por fluor y R2 es alcoxi C1-4, cicloalcoxi C3-7, cicloalquilmetoxi C3-7, o alcoxi C1-4 sustituido en forma predominante o sustituido por fluor, o R1 y R2 juntos forman un grupo alquilendioxi C1-2, R3 es un anillo heterocíclico de cinco miembros, que está sustituido por R4 y se selecciona de pirazol-3-ilo, pirazol-4-ilo, tiofen-2-ilo, tiofen-3-ilo, imidazol-2-ilo, imidazol-4-ilo, isoxazol-3-iIo, isoxazol-4-ilo, isoxazol-5-ilo, 1,3-oxazol-2-ilo, 1,3-oxazol-4-ilo, 1,3-oxazol-5-ilo, 1,3-tiazol-2-ilo, 1,3-tiazol-4-ilo, 1,3-tiazol-5-ilo, 1,2,3-triazol-4-ilo, 1,2,4-triazol-3-ilo, 1,2,4-oxadiazol-3-ilo, 1,2,4-oxadiazol-5-ilo, 1,3,4-oxadiazol-2-ilo, 1,2,4-tiadiazol-5-ilo, 1,2,4-tiadiazoi-3-iIo, 1,3,4-tiadiazol-2-ilo, tetrazol-2-ilo o tetrazol-5-ilo, en donde R4 es alquilo es C1-4, metoximetilo, metoxietilo, metoxipropilo, etoximetilo, propiloximetilo, etoxietilo, metilsulfanilmetilo, metilsulfaniletilo, metilsulfanil-propilo, etilsulfanilmetilo, propilsulfanilmetilo o etilsulfaniletilo, R5 es fenilo no sustituido, fenilo sustituido por R6 o fenilo sustituido por R6 y R7, en donde R6 es halogeno, alquilo C1-4 o alcoxi C1-4, y R7 es halogeno, alquilo C1-4 o alcoxi C1-4, o R6 y R7 juntos forman un grupo alquilendioxi C1-2, o un estereoisomero del compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179982 | 2009-12-18 | ||
| US31555210P | 2010-03-19 | 2010-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079451A1 true AR079451A1 (es) | 2012-01-25 |
Family
ID=41718903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104617A AR079451A1 (es) | 2009-12-18 | 2010-12-14 | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9018175B2 (es) |
| EP (2) | EP2813509B1 (es) |
| JP (1) | JP5645961B2 (es) |
| KR (1) | KR20120123313A (es) |
| CN (1) | CN102652136B (es) |
| AR (1) | AR079451A1 (es) |
| AU (1) | AU2010332955B8 (es) |
| BR (1) | BR112012014058A8 (es) |
| CA (1) | CA2784013A1 (es) |
| CO (1) | CO6551705A2 (es) |
| DK (1) | DK2513119T3 (es) |
| EA (1) | EA023212B1 (es) |
| ES (2) | ES2505290T3 (es) |
| GE (1) | GEP20146105B (es) |
| HR (1) | HRP20140893T1 (es) |
| ME (1) | ME01914B (es) |
| MX (1) | MX2012006696A (es) |
| NZ (1) | NZ601115A (es) |
| PH (1) | PH12012501125A1 (es) |
| PL (1) | PL2513119T3 (es) |
| PT (1) | PT2513119E (es) |
| RS (1) | RS53544B1 (es) |
| SG (2) | SG180824A1 (es) |
| SI (1) | SI2513119T1 (es) |
| SM (1) | SMT201400185B (es) |
| TW (1) | TWI468411B (es) |
| UA (1) | UA107689C2 (es) |
| WO (1) | WO2011073231A1 (es) |
| ZA (1) | ZA201204135B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101930561B1 (ko) | 2010-06-07 | 2018-12-18 | 사푸라스트 리써치 엘엘씨 | 재충전 가능한 고밀도 전기 화학 장치 |
| RU2013142268A (ru) * | 2011-02-17 | 2015-03-27 | Сипла Лимитед | Фармацевтическая композиция |
| US20140113877A1 (en) | 2011-06-15 | 2014-04-24 | Takeda Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c] isoquinoline compounds |
| WO2014016548A2 (en) * | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| US20150322049A1 (en) * | 2012-12-13 | 2015-11-12 | Ludwig Aigner | Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease |
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