MX2012006696A - Derivados de 3, 4, 4a, 10b-tetrahidro-1h-tiopirano-[4, 3-c]-isoqunolina. - Google Patents
Derivados de 3, 4, 4a, 10b-tetrahidro-1h-tiopirano-[4, 3-c]-isoqunolina.Info
- Publication number
- MX2012006696A MX2012006696A MX2012006696A MX2012006696A MX2012006696A MX 2012006696 A MX2012006696 A MX 2012006696A MX 2012006696 A MX2012006696 A MX 2012006696A MX 2012006696 A MX2012006696 A MX 2012006696A MX 2012006696 A MX2012006696 A MX 2012006696A
- Authority
- MX
- Mexico
- Prior art keywords
- thiopyrano
- tetrahydro
- isoquinoline derivatives
- isoquinoline
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
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- Cardiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
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Abstract
Los compuestos de la fórmula (1), en donde A, R1, R2, R3 y R5 tienen los significados como se dan en la descripción, son novedosos inhibidores efectivos de la fosfodiesterasa tipo 4 y 5 (Ver Formula).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179982 | 2009-12-18 | ||
| US31555210P | 2010-03-19 | 2010-03-19 | |
| PCT/EP2010/069704 WO2011073231A1 (en) | 2009-12-18 | 2010-12-15 | 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4, 3-c] ISOQUINOLINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012006696A true MX2012006696A (es) | 2012-07-17 |
Family
ID=41718903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012006696A MX2012006696A (es) | 2009-12-18 | 2010-12-15 | Derivados de 3, 4, 4a, 10b-tetrahidro-1h-tiopirano-[4, 3-c]-isoqunolina. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9018175B2 (es) |
| EP (2) | EP2813509B1 (es) |
| JP (1) | JP5645961B2 (es) |
| KR (1) | KR20120123313A (es) |
| CN (1) | CN102652136B (es) |
| AR (1) | AR079451A1 (es) |
| AU (1) | AU2010332955B8 (es) |
| BR (1) | BR112012014058A8 (es) |
| CA (1) | CA2784013A1 (es) |
| CO (1) | CO6551705A2 (es) |
| DK (1) | DK2513119T3 (es) |
| EA (1) | EA023212B1 (es) |
| ES (2) | ES2505290T3 (es) |
| GE (1) | GEP20146105B (es) |
| HK (1) | HK1174326A1 (es) |
| HR (1) | HRP20140893T1 (es) |
| ME (1) | ME01914B (es) |
| MX (1) | MX2012006696A (es) |
| NZ (1) | NZ601115A (es) |
| PL (1) | PL2513119T3 (es) |
| PT (1) | PT2513119E (es) |
| RS (1) | RS53544B1 (es) |
| SG (2) | SG196785A1 (es) |
| SI (1) | SI2513119T1 (es) |
| SM (1) | SMT201400185B (es) |
| TW (1) | TWI468411B (es) |
| UA (1) | UA107689C2 (es) |
| WO (1) | WO2011073231A1 (es) |
| ZA (1) | ZA201204135B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102947976B (zh) | 2010-06-07 | 2018-03-16 | 萨普拉斯特研究有限责任公司 | 可充电、高密度的电化学设备 |
| CN103501776A (zh) * | 2011-02-17 | 2014-01-08 | 西普拉有限公司 | 甘罗铵与β2激动剂的组合物 |
| WO2012171903A1 (en) | 2011-06-15 | 2012-12-20 | Nycomed Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds |
| WO2014016548A2 (en) * | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| US20150322049A1 (en) * | 2012-12-13 | 2015-11-12 | Ludwig Aigner | Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease |
| WO2014117947A1 (en) | 2013-02-04 | 2014-08-07 | Grünenthal GmbH | 4-amino substituted condensed pyrimidine compounds as pde4 inhibitors |
| AP2015008663A0 (en) | 2013-02-19 | 2015-08-31 | Pfizer | Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of cns and other disorders |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| CU20170007A7 (es) | 2014-08-06 | 2017-06-05 | Pfizer | Compuestos de imidazopiridazina |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
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| US3899494A (en) | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| DE2047465A1 (de) | 1970-09-26 | 1972-03-30 | Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt | Neue Oxdiazole und Verfahren zu lh rer Herstellung |
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| JPH01213284A (ja) | 1988-02-22 | 1989-08-28 | Sankyo Co Ltd | チエノピリミジン−２，４−ジオン誘導体 |
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| EP0407028B2 (en) | 1989-05-31 | 1999-07-07 | FISONS plc | Medicament inhalation device and formulation |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| DE69131867T2 (de) | 1990-03-23 | 2000-05-18 | Minnesota Mining & Mfg | Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe |
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| GB9306703D0 (en) | 1993-03-31 | 1993-05-26 | Fisons Plc | Inhalation device |
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| EP1102579B1 (de) | 1998-08-04 | 2003-03-19 | Jago Research Ag | Medizinische aerosolformulierungen |
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| ZA200609228B (en) | 2004-04-23 | 2008-05-28 | Celgene Corp | Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension |
| JP5009799B2 (ja) * | 2004-09-08 | 2012-08-22 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の３−オキサ−１０−アザ−フェナントレン |
| WO2006027345A2 (en) * | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
| WO2006054560A1 (ja) | 2004-11-17 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途 |
| CA2599368A1 (en) | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| MX2009011089A (es) * | 2007-04-23 | 2009-10-30 | Sanofi Aventis | Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. |
| WO2012171903A1 (en) * | 2011-06-15 | 2012-12-20 | Nycomed Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds |
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