CO6551705A2 - Derivados de 3.4.4a.10b- tetrahidro-1h-tiopirano-[4.3-c]- isoquinolina - Google Patents
Derivados de 3.4.4a.10b- tetrahidro-1h-tiopirano-[4.3-c]- isoquinolinaInfo
- Publication number
- CO6551705A2 CO6551705A2 CO12085785A CO12085785A CO6551705A2 CO 6551705 A2 CO6551705 A2 CO 6551705A2 CO 12085785 A CO12085785 A CO 12085785A CO 12085785 A CO12085785 A CO 12085785A CO 6551705 A2 CO6551705 A2 CO 6551705A2
- Authority
- CO
- Colombia
- Prior art keywords
- tiopirano
- isoquinolina
- tetrahidro
- derivatives
- meanings
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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Abstract
Los compuestos de la fórmula (I), en donde A, R1, R2, R3 y R5 tienen los significados como se dan en la descripción, son novedosos inhibidores efectivos de la fosfodiesterasa tipo 4 y 5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179982 | 2009-12-18 | ||
| US31555210P | 2010-03-19 | 2010-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6551705A2 true CO6551705A2 (es) | 2012-10-31 |
Family
ID=41718903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12085785A CO6551705A2 (es) | 2009-12-18 | 2012-05-24 | Derivados de 3.4.4a.10b- tetrahidro-1h-tiopirano-[4.3-c]- isoquinolina |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9018175B2 (es) |
| EP (2) | EP2813509B1 (es) |
| JP (1) | JP5645961B2 (es) |
| KR (1) | KR20120123313A (es) |
| CN (1) | CN102652136B (es) |
| AR (1) | AR079451A1 (es) |
| AU (1) | AU2010332955B8 (es) |
| BR (1) | BR112012014058A8 (es) |
| CA (1) | CA2784013A1 (es) |
| CO (1) | CO6551705A2 (es) |
| DK (1) | DK2513119T3 (es) |
| EA (1) | EA023212B1 (es) |
| ES (2) | ES2621291T3 (es) |
| GE (1) | GEP20146105B (es) |
| HK (1) | HK1174326A1 (es) |
| HR (1) | HRP20140893T1 (es) |
| ME (1) | ME01914B (es) |
| MX (1) | MX2012006696A (es) |
| NZ (1) | NZ601115A (es) |
| PL (1) | PL2513119T3 (es) |
| PT (1) | PT2513119E (es) |
| RS (1) | RS53544B1 (es) |
| SG (2) | SG196785A1 (es) |
| SI (1) | SI2513119T1 (es) |
| SM (1) | SMT201400185B (es) |
| TW (1) | TWI468411B (es) |
| UA (1) | UA107689C2 (es) |
| WO (1) | WO2011073231A1 (es) |
| ZA (1) | ZA201204135B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013528912A (ja) | 2010-06-07 | 2013-07-11 | インフィニット パワー ソリューションズ， インコーポレイテッド | 再充電可能高密度電気化学素子 |
| EP2675439A2 (en) * | 2011-02-17 | 2013-12-25 | Cipla Limited | Combination of glycopyrrolate and a beta2 -agonist |
| US20140113877A1 (en) | 2011-06-15 | 2014-04-24 | Takeda Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c] isoquinoline compounds |
| WO2014016548A2 (en) * | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| US20150322049A1 (en) * | 2012-12-13 | 2015-11-12 | Ludwig Aigner | Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease |
| AU2014211755B2 (en) | 2013-02-04 | 2017-07-06 | Grunenthal Gmbh | 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors |
| MX2015010714A (es) | 2013-02-19 | 2016-06-14 | Pfizer | Compuestos de azabencimidazol. |
| EP3172210B1 (en) | 2014-07-24 | 2020-01-15 | Pfizer Inc | Pyrazolopyrimidine compounds |
| KR102061952B1 (ko) | 2014-08-06 | 2020-01-02 | 화이자 인코포레이티드 | 이미다조피리다진 화합물 |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
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| US3899494A (en) | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| DE2047465A1 (de) | 1970-09-26 | 1972-03-30 | Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt | Neue Oxdiazole und Verfahren zu lh rer Herstellung |
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| JPH01213284A (ja) | 1988-02-22 | 1989-08-28 | Sankyo Co Ltd | チエノピリミジン−２，４−ジオン誘導体 |
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| ATE111364T1 (de) | 1989-05-31 | 1994-09-15 | Fisons Plc | Medikament und inhalationsvorrichtung dafür. |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
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| WO2006027344A2 (en) | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
| EP1813603A1 (en) | 2004-11-17 | 2007-08-01 | Kissei Pharmaceutical Co., Ltd. | Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both |
| AU2006221957A1 (en) | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| KR20100015886A (ko) | 2007-04-23 | 2010-02-12 | 사노피-아벤티스 | Ｐ2ｙ12 길항제로서의 퀴놀린-카복스아미드 유도체 |
| US20140113877A1 (en) * | 2011-06-15 | 2014-04-24 | Takeda Gmbh | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c] isoquinoline compounds |
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