CR20130349A - COMPUESTOS SUSTITUIDOS DE N-(1H- INDAZOL-4-IL) IMIDAZO [1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III - Google Patents

COMPUESTOS SUSTITUIDOS DE N-(1H- INDAZOL-4-IL) IMIDAZO [1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III

Info

Publication number
CR20130349A
CR20130349A CR20130349A CR20130349A CR20130349A CR 20130349 A CR20130349 A CR 20130349A CR 20130349 A CR20130349 A CR 20130349A CR 20130349 A CR20130349 A CR 20130349A CR 20130349 A CR20130349 A CR 20130349A
Authority
CR
Costa Rica
Prior art keywords
type
kinosa
piridin
indazol
imidazo
Prior art date
Application number
CR20130349A
Other languages
English (en)
Inventor
Mark Laurence Boys
Robert Kirk Delisle
Erik James Hicken
April L Kennedy
David A Mareska
Fredrik P Marmsater
Mark C Munson
Brad Newhouse
Bryson Rast
James P Rizzi
Martha E Rodriguez
George T Topalov
Qian Zhao
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CR20130349A publication Critical patent/CR20130349A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

COMPUESTOS DE FÓRMULA I.-
CR20130349A 2010-12-13 2013-07-15 COMPUESTOS SUSTITUIDOS DE N-(1H- INDAZOL-4-IL) IMIDAZO [1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III CR20130349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42254710P 2010-12-13 2010-12-13
PCT/US2011/064549 WO2012082689A1 (en) 2010-12-13 2011-12-13 SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
CR20130349A true CR20130349A (es) 2013-08-09

Family

ID=45478484

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130349A CR20130349A (es) 2010-12-13 2013-07-15 COMPUESTOS SUSTITUIDOS DE N-(1H- INDAZOL-4-IL) IMIDAZO [1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III

Country Status (32)

Country Link
US (3) US9174981B2 (es)
EP (1) EP2651939B1 (es)
JP (3) JP5868996B2 (es)
KR (1) KR101974665B1 (es)
CN (3) CN109608449A (es)
AU (3) AU2011344001B2 (es)
BR (1) BR112013014854B1 (es)
CA (2) CA3027814A1 (es)
CL (1) CL2013001712A1 (es)
CO (1) CO6751248A2 (es)
CR (1) CR20130349A (es)
DK (1) DK2651939T3 (es)
ES (1) ES2540996T3 (es)
HK (1) HK1190709A1 (es)
HR (1) HRP20150571T1 (es)
HU (1) HUE025416T2 (es)
IL (1) IL226911A (es)
ME (1) ME02172B (es)
MX (1) MX2013006763A (es)
MY (1) MY172110A (es)
NZ (1) NZ613235A (es)
PL (1) PL2651939T3 (es)
PT (1) PT2651939E (es)
RS (1) RS54070B1 (es)
RU (1) RU2591195C2 (es)
SG (1) SG191129A1 (es)
SI (1) SI2651939T1 (es)
SM (1) SMT201500165B (es)
TW (1) TWI527813B (es)
UA (1) UA112425C2 (es)
UY (1) UY33801A (es)
WO (1) WO2012082689A1 (es)

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RU2562977C2 (ru) * 2009-12-21 2015-09-10 Эррэй Биофарма Инк. СОЕДИНЕНИЯ ЗАМЕЩЕННОГО N-(1Н-ИНДАЗОЛ-4-ИЛ)ИМИДАЗОЛ[1,2-a]ПИРИДИН-3-КАРБОКСАМИДА КАК ИНГИБИТОРЫ cFMS
CA3027814A1 (en) * 2010-12-13 2012-06-21 Array Biopharma Inc. Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as intermediates for type iii receptor tyrosine kinase inhibitors
GB201315486D0 (en) * 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
CN104496891A (zh) * 2014-12-06 2015-04-08 哈尔滨工业大学 吡啶衍生物2-叔丁氧基-6-亚甲基氯吡啶的合成方法
CN104974078A (zh) * 2015-06-25 2015-10-14 黄荣辉 一种2-甲基-6-氯甲基吡啶盐酸盐的制备方法
US10501438B2 (en) 2015-08-11 2019-12-10 Neomed Institute Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
US10836742B2 (en) 2015-08-11 2020-11-17 Neomed Institute N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
ES2904258T3 (es) 2015-08-12 2022-04-04 Neomed Inst Bencimidazoles sustituidos, su preparación y su uso como productos farmacéuticos
WO2017066876A1 (en) 2015-10-21 2017-04-27 Neomed Institute Substituted imidazopyridines, their preparation and their use as pharmaceuticals
EP3371172B1 (en) 2015-11-02 2021-10-20 Genase Therapeutics B.V. Tetrahydroindazoles and medical uses thereof
CN105198799A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-6-氯甲基吡啶盐酸盐的制备方法
WO2017127930A1 (en) 2016-01-28 2017-08-03 Neomed Institute Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals
ES2810852T3 (es) * 2016-06-14 2021-03-09 Novartis Ag Compuestos y composiciones para inhibir la actividad de shp2
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
WO2018019291A1 (en) * 2016-07-29 2018-02-01 The Hong Kong University Of Science And Technology C(sp3)-c(sp2) cross-coupling reaction of organozinc reagents and heterocyclic (pseudo)halides
WO2018083635A2 (en) 2016-11-04 2018-05-11 Auckland Uniservices Limited Tricyclic heterocyclic derivatives and uses thereof
JP6346368B1 (ja) * 2016-11-28 2018-06-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 インダゾール誘導体の塩及びその結晶
UA125317C2 (uk) 2017-07-28 2022-02-16 Юхан Корпорейшн Удосконалений спосіб отримання похідних амінопіримідину
CA3093802A1 (en) 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
CN111410654B (zh) * 2019-01-19 2022-05-17 江苏新元素医药科技有限公司 3-溴-5-(2-乙基咪唑并[1,2-a]吡啶-3-羰基)-2-羟基苯甲腈的合成
TW202043239A (zh) 2019-01-24 2020-12-01 日商第一三共股份有限公司 具有取代基之脲化合物
EP4031547A1 (en) 2019-09-18 2022-07-27 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof
EP4031245A1 (en) 2019-09-18 2022-07-27 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors

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BRPI0809998B8 (pt) * 2007-04-03 2021-05-25 Array Biopharma Inc composto de imidazo[1,2-a] piridina como inibidores do receptor tirosina quinase, seus usos, seus processos de preparação e composições farmacêuticas
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Also Published As

Publication number Publication date
US9809590B2 (en) 2017-11-07
ES2540996T3 (es) 2015-07-15
TW201305156A (zh) 2013-02-01
CA2821712C (en) 2019-02-12
AU2018201903B2 (en) 2019-09-19
JP2013545808A (ja) 2013-12-26
JP5868996B2 (ja) 2016-02-24
US10669269B2 (en) 2020-06-02
KR20140014109A (ko) 2014-02-05
UA112425C2 (uk) 2016-09-12
SI2651939T1 (sl) 2015-07-31
US20130274244A1 (en) 2013-10-17
SMT201500165B (it) 2015-09-07
PL2651939T3 (pl) 2015-10-30
CN103347882B (zh) 2016-05-11
NZ613235A (en) 2015-04-24
CA3027814A1 (en) 2012-06-21
BR112013014854B1 (pt) 2020-12-08
BR112013014854A8 (pt) 2018-03-27
MY172110A (en) 2019-11-14
AU2016222468A1 (en) 2016-09-22
PT2651939E (pt) 2015-08-04
RS54070B1 (en) 2015-10-30
HRP20150571T1 (en) 2015-07-03
KR101974665B1 (ko) 2019-05-02
US20160002232A1 (en) 2016-01-07
CO6751248A2 (es) 2013-09-16
US9174981B2 (en) 2015-11-03
US20180086758A1 (en) 2018-03-29
CL2013001712A1 (es) 2013-12-06
CN105924437B (zh) 2018-11-30
UY33801A (es) 2013-06-28
IL226911A (en) 2016-09-29
TWI527813B (zh) 2016-04-01
JP2016040303A (ja) 2016-03-24
AU2018201903A1 (en) 2018-04-12
AU2016222468B2 (en) 2017-12-21
EP2651939A1 (en) 2013-10-23
HK1190709A1 (en) 2014-07-11
CA2821712A1 (en) 2012-06-21
CN103347882A (zh) 2013-10-09
RU2591195C2 (ru) 2016-07-10
HUE025416T2 (en) 2016-02-29
DK2651939T3 (en) 2015-06-01
BR112013014854A2 (pt) 2016-10-18
ME02172B (me) 2015-10-20
RU2013132758A (ru) 2015-01-20
SG191129A1 (en) 2013-07-31
WO2012082689A1 (en) 2012-06-21
AU2011344001B2 (en) 2016-06-30
CN105924437A (zh) 2016-09-07
CN109608449A (zh) 2019-04-12
JP2018065835A (ja) 2018-04-26
MX2013006763A (es) 2014-01-08
EP2651939B1 (en) 2015-04-08

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