UY34445A - Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a - Google Patents
Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10aInfo
- Publication number
- UY34445A UY34445A UY0001034445A UY34445A UY34445A UY 34445 A UY34445 A UY 34445A UY 0001034445 A UY0001034445 A UY 0001034445A UY 34445 A UY34445 A UY 34445A UY 34445 A UY34445 A UY 34445A
- Authority
- UY
- Uruguay
- Prior art keywords
- phosphodiesterase
- type
- inhibiting compounds
- new
- new inhibiting
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Compuestos de fórmula I, inhibidores de la fosfodiesterasa del tipo 10A apropiados para tratar o co ntrolar trastornos neurológicos y psiquiátricos, y para reducir el riesgo de que se desarrollen. Do nde los sustituyentes son como se los define en las reivindicaciones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161557874P | 2011-11-09 | 2011-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34445A true UY34445A (es) | 2013-06-28 |
Family
ID=47178004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001034445A UY34445A (es) | 2011-11-09 | 2012-11-09 | Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a |
Country Status (25)
Country | Link |
---|---|
US (3) | US20130116241A1 (es) |
EP (1) | EP2776418B1 (es) |
JP (1) | JP2014534976A (es) |
KR (1) | KR20140097318A (es) |
CN (1) | CN104053654A (es) |
AR (1) | AR088801A1 (es) |
AU (1) | AU2012334074A1 (es) |
BR (1) | BR112014011284A2 (es) |
CA (1) | CA2852604A1 (es) |
CL (1) | CL2014001212A1 (es) |
CO (1) | CO7030959A2 (es) |
CR (1) | CR20140223A (es) |
DO (1) | DOP2014000097A (es) |
ES (1) | ES2620531T3 (es) |
GT (1) | GT201400089A (es) |
HK (1) | HK1201519A1 (es) |
IL (1) | IL232358A0 (es) |
MX (1) | MX2014005714A (es) |
PE (1) | PE20141938A1 (es) |
RU (1) | RU2014123316A (es) |
SG (1) | SG11201402142VA (es) |
TW (1) | TW201326153A (es) |
UY (1) | UY34445A (es) |
WO (1) | WO2013068470A1 (es) |
ZA (1) | ZA201402966B (es) |
Families Citing this family (35)
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US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
US9200005B2 (en) * | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
KR20160007598A (ko) | 2013-05-10 | 2016-01-20 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
MX2015015416A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
KR20160005364A (ko) | 2013-05-10 | 2016-01-14 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
JP6434498B2 (ja) | 2013-05-10 | 2018-12-05 | ギリアド アポロ, エルエルシー | Acc阻害剤及びその使用 |
US9249163B2 (en) | 2013-06-11 | 2016-02-02 | Janssen Pharmaceutica Nv. | PDE10a inhibitors for the treatment of type II diabetes |
WO2014200882A1 (en) | 2013-06-11 | 2014-12-18 | Janssen Pharmaceutica Nv | PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES |
US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
CR20160463A (es) * | 2014-04-04 | 2017-03-06 | H Lundbeck As | Quinazolin-thf-aminas halogenadas como inhibidores de pde1 |
JP6626449B2 (ja) * | 2014-04-23 | 2019-12-25 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | PDE2阻害剤としての置換[1,2,4]トリアゾロ[1,5−a]ピリミジン−7−イル化合物 |
GB201416352D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
TWI770525B (zh) | 2014-12-30 | 2022-07-11 | 美商瓦洛健康公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
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WO2016126929A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
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CN105669680B (zh) * | 2016-03-24 | 2018-02-23 | 南京药捷安康生物科技有限公司 | 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂 |
CA3026578A1 (en) | 2016-06-22 | 2017-12-28 | Vanderbilt Universtiy | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
CN109890388B (zh) * | 2016-11-07 | 2023-03-28 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
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CN109863139B (zh) | 2016-11-07 | 2023-02-17 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
CN108084199A (zh) * | 2017-06-13 | 2018-05-29 | 长沙理工大学 | 一种合成呋喃并[3,2-c]吡啶-4(5H)-酮衍生物的方法 |
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IL272667B (en) | 2017-10-18 | 2022-09-01 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
US11459338B2 (en) | 2017-11-24 | 2022-10-04 | Jubilant Episcribe Llc | Heterocyclic compounds as PRMT5 inhibitors |
JP2021505581A (ja) | 2017-12-05 | 2021-02-18 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターm4のポジティブアロステリック調節因子 |
TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
KR20200131845A (ko) | 2018-03-13 | 2020-11-24 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 상호작용/활성화 억제제로서의 비사이클릭 화합물 |
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-
2012
- 2012-10-25 US US13/660,524 patent/US20130116241A1/en not_active Abandoned
- 2012-10-29 US US13/663,008 patent/US9273068B2/en not_active Expired - Fee Related
- 2012-11-08 AU AU2012334074A patent/AU2012334074A1/en not_active Abandoned
- 2012-11-08 BR BR112014011284A patent/BR112014011284A2/pt not_active IP Right Cessation
- 2012-11-08 CA CA2852604A patent/CA2852604A1/en not_active Abandoned
- 2012-11-08 AR ARP120104208A patent/AR088801A1/es unknown
- 2012-11-08 EP EP12784578.2A patent/EP2776418B1/en not_active Not-in-force
- 2012-11-08 JP JP2014540459A patent/JP2014534976A/ja active Pending
- 2012-11-08 RU RU2014123316/04A patent/RU2014123316A/ru not_active Application Discontinuation
- 2012-11-08 CN CN201280052929.8A patent/CN104053654A/zh active Pending
- 2012-11-08 ES ES12784578T patent/ES2620531T3/es active Active
- 2012-11-08 WO PCT/EP2012/072150 patent/WO2013068470A1/en active Application Filing
- 2012-11-08 KR KR1020147015427A patent/KR20140097318A/ko not_active Application Discontinuation
- 2012-11-08 MX MX2014005714A patent/MX2014005714A/es unknown
- 2012-11-08 SG SG11201402142VA patent/SG11201402142VA/en unknown
- 2012-11-08 PE PE2014000642A patent/PE20141938A1/es not_active Application Discontinuation
- 2012-11-09 TW TW101141932A patent/TW201326153A/zh unknown
- 2012-11-09 UY UY0001034445A patent/UY34445A/es not_active Application Discontinuation
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2014
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- 2014-04-29 IL IL232358A patent/IL232358A0/en unknown
- 2014-05-07 GT GT201400089A patent/GT201400089A/es unknown
- 2014-05-08 CL CL2014001212A patent/CL2014001212A1/es unknown
- 2014-05-08 DO DO2014000097A patent/DOP2014000097A/es unknown
- 2014-05-14 CR CR20140223A patent/CR20140223A/es unknown
- 2014-06-04 CO CO14119455A patent/CO7030959A2/es unknown
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2015
- 2015-02-23 HK HK15101856.4A patent/HK1201519A1/xx unknown
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2016
- 2016-01-18 US US14/997,997 patent/US9657034B2/en active Active
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AU2012334074A1 (en) | 2014-05-01 |
EP2776418B1 (en) | 2017-01-04 |
AR088801A1 (es) | 2014-07-10 |
ZA201402966B (en) | 2017-08-30 |
CR20140223A (es) | 2014-09-09 |
WO2013068470A1 (en) | 2013-05-16 |
US20160137668A1 (en) | 2016-05-19 |
RU2014123316A (ru) | 2015-12-20 |
CN104053654A (zh) | 2014-09-17 |
GT201400089A (es) | 2015-09-30 |
SG11201402142VA (en) | 2014-06-27 |
CL2014001212A1 (es) | 2014-11-28 |
US20130116241A1 (en) | 2013-05-09 |
KR20140097318A (ko) | 2014-08-06 |
TW201326153A (zh) | 2013-07-01 |
CA2852604A1 (en) | 2013-05-16 |
PE20141938A1 (es) | 2014-12-28 |
NZ623727A (en) | 2016-06-24 |
HK1201519A1 (en) | 2015-09-04 |
ES2620531T3 (es) | 2017-06-28 |
CO7030959A2 (es) | 2014-08-21 |
MX2014005714A (es) | 2014-09-04 |
US9657034B2 (en) | 2017-05-23 |
JP2014534976A (ja) | 2014-12-25 |
BR112014011284A2 (pt) | 2017-05-02 |
IL232358A0 (en) | 2014-07-01 |
DOP2014000097A (es) | 2014-07-15 |
US9273068B2 (en) | 2016-03-01 |
US20130116233A1 (en) | 2013-05-09 |
EP2776418A1 (en) | 2014-09-17 |
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