UY34523A - Derivados de betulina - Google Patents

Derivados de betulina

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Publication number
UY34523A
UY34523A UY0001034523A UY34523A UY34523A UY 34523 A UY34523 A UY 34523A UY 0001034523 A UY0001034523 A UY 0001034523A UY 34523 A UY34523 A UY 34523A UY 34523 A UY34523 A UY 34523A
Authority
UY
Uruguay
Prior art keywords
betulin derivatives
betulin
derivatives
página
escanear
Prior art date
Application number
UY0001034523A
Other languages
English (en)
Inventor
Brian Alvin Johns
Mark Andrew Hatcher
Michael Tolar Martin
Elie Amine Tabet
Tang Jun
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201161576448P priority Critical
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of UY34523A publication Critical patent/UY34523A/es

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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
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    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002Carbocyclic rings fused
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/52Ortho- or ortho- and peri-condensed systems containing five condensed rings

Abstract

La presente invención se refiere a compuestos caracterizados por tener una estructura de acuerdo con la siguiente fórmula I:o una sal farmacéuticamente aceptable de los mismos. Los compuestos de la presente invención son útiles para el tratamiento o la prevención de VIH.
UY0001034523A 2011-12-16 2012-12-17 Derivados de betulina UY34523A (es)

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US20130184263A1 (en) 2013-07-18
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JP2018065867A (ja) 2018-04-26
SG11201402707PA (en) 2014-09-26
US20170348324A1 (en) 2017-12-07
ES2644578T3 (es) 2017-11-29
US9102685B2 (en) 2015-08-11
AU2012352110A1 (en) 2014-07-10
PH12014501362B1 (en) 2014-09-22
EP2791103A1 (en) 2014-10-22
US20150218142A1 (en) 2015-08-06
ME02895B (me) 2018-04-20
MX360679B (es) 2018-11-13
TW201336862A (zh) 2013-09-16
HUE034877T2 (hu) 2018-03-28
EP2791103A4 (en) 2015-05-06
EP3263580A1 (en) 2018-01-03
MA35833B1 (fr) 2014-12-01
PL2791103T3 (pl) 2018-02-28
DK2791103T3 (en) 2017-10-02
AR089285A1 (es) 2014-08-13
MX2014007280A (es) 2014-07-22
JP2015501845A (ja) 2015-01-19
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HK1210180A1 (en) 2016-04-15
LT2791103T (lt) 2017-10-25
BR112014014769A2 (pt) 2017-06-13
EA201490919A1 (ru) 2014-11-28
ZA201404135B (en) 2019-04-24
RS56373B1 (sr) 2017-12-29
CL2014001585A1 (es) 2015-02-27
JP6300730B2 (ja) 2018-03-28
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CA2859030A1 (en) 2013-06-20
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EA027363B1 (ru) 2017-07-31
US20160120878A1 (en) 2016-05-05
IL233081D0 (en) 2014-08-03
CY1119422T1 (el) 2018-03-07
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US20140357643A1 (en) 2014-12-04
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