CR20140468A - Inhibidores de diacilglicerol aciltransferasa 2 - Google Patents

Inhibidores de diacilglicerol aciltransferasa 2

Info

Publication number
CR20140468A
CR20140468A CR20140468A CR20140468A CR20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A
Authority
CR
Costa Rica
Prior art keywords
diacilglicerol
aciltransferasa
inhibitors
compounds
formula
Prior art date
Application number
CR20140468A
Other languages
English (en)
Inventor
Kay Ahn
Markus Boehm
Shawn Cabral
Philip A Carpino
Kentaro Futatsugi
David Hepworth
Daniel W Kung
Suvi Orr
Jian Wang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140468(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CR20140468A publication Critical patent/CR20140468A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

En la presente se describen compuestos de la fórmula I.
CR20140468A 2012-04-06 2014-10-06 Inhibidores de diacilglicerol aciltransferasa 2 CR20140468A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06
PCT/IB2013/052404 WO2013150416A1 (en) 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors

Publications (1)

Publication Number Publication Date
CR20140468A true CR20140468A (es) 2014-11-17

Family

ID=48428540

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140468A CR20140468A (es) 2012-04-06 2014-10-06 Inhibidores de diacilglicerol aciltransferasa 2

Country Status (27)

Country Link
US (1) US9296745B2 (es)
EP (1) EP2834238B1 (es)
JP (1) JP2015515472A (es)
KR (1) KR20140137404A (es)
CN (1) CN104334557A (es)
AP (1) AP2014007953A0 (es)
AU (1) AU2013245353A1 (es)
CA (1) CA2869587A1 (es)
CL (1) CL2014002541A1 (es)
CO (1) CO7160030A2 (es)
CR (1) CR20140468A (es)
CU (1) CU20140115A7 (es)
DO (1) DOP2014000225A (es)
EA (1) EA201400990A1 (es)
EC (1) ECSP14021251A (es)
GT (1) GT201400213A (es)
HK (1) HK1206735A1 (es)
IL (1) IL234928A0 (es)
MA (1) MA37385B1 (es)
MD (1) MD20140103A2 (es)
MX (1) MX2014011373A (es)
NI (1) NI201400120A (es)
PE (1) PE20142164A1 (es)
PH (1) PH12014502057A1 (es)
SG (1) SG11201405477XA (es)
TN (1) TN2014000419A1 (es)
WO (1) WO2013150416A1 (es)

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SI3119757T1 (en) * 2014-03-17 2018-08-31 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
CN107567443B (zh) * 2014-12-24 2023-04-28 株式会社Lg化学 作为gpr120激动剂的联芳基衍生物
JP6413032B2 (ja) 2015-05-20 2018-10-24 イーライ リリー アンド カンパニー 新規ｄｇａｔ２阻害剤
AU2016294347B2 (en) * 2015-07-10 2022-07-28 Ionis Pharmaceuticals, Inc. Modulators of diacyglycerol acyltransferase 2 (DGAT2)
US20190055212A1 (en) * 2016-02-16 2019-02-21 Stephen Gwaltney Histone demethylase inhibitors
AR109179A1 (es) * 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
TWI841671B (zh) 2019-01-24 2024-05-11 日商第一三共股份有限公司 具有取代基之脲化合物
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
EP4153596A4 (en) * 2020-05-18 2024-08-14 Merck Sharp & Dohme LLC NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
CN116075510A (zh) * 2020-08-19 2023-05-05 百时美施贵宝公司 1H-苯并[d]咪唑衍生物作为TLR9抑制剂用于治疗纤维化
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
PE20240217A1 (es) 2020-10-08 2024-02-16 Merck Sharp And Dohme Llc Preparacion de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
TW202229243A (zh) 2020-10-08 2022-08-01 美商默沙東藥廠 作為新穎二醯基甘油酯o-醯基轉移酶2抑制劑之苯并咪唑酮衍生物的製備
UY39484A (es) * 2020-11-02 2022-06-30 Novartis Ag Inhibidores de interleucina-17
US12540132B2 (en) 2020-12-22 2026-02-03 Merck Sharp & Dohme Llc Preparation of tetrahydroindazole derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
IL314945A (en) * 2022-02-18 2024-10-01 Bristol Myers Squibb Co Substituted imidazopyridinyl compounds useful as inhibitors of tlr9
IL321166A (en) 2022-12-02 2025-07-01 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
WO2025194014A1 (en) * 2024-03-15 2025-09-18 Dem Biopharma, Inc. Hetero aryl modulators of apmap and uses thereof

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TN2014000419A1 (fr) 2016-03-30
MA37385A3 (fr) 2016-12-30
AU2013245353A1 (en) 2014-09-25
KR20140137404A (ko) 2014-12-02
GT201400213A (es) 2015-06-02
CN104334557A (zh) 2015-02-04
AP2014007953A0 (en) 2014-09-30
CA2869587A1 (en) 2013-10-10
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US9296745B2 (en) 2016-03-29
PE20142164A1 (es) 2014-12-27
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