CR20140468A - Inhibidores de diacilglicerol aciltransferasa 2 - Google Patents

Inhibidores de diacilglicerol aciltransferasa 2

Info

Publication number
CR20140468A
CR20140468A CR20140468A CR20140468A CR20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A CR 20140468 A CR20140468 A CR 20140468A
Authority
CR
Costa Rica
Prior art keywords
diacilglicerol
aciltransferasa
inhibitors
compounds
formula
Prior art date
Application number
CR20140468A
Other languages
English (en)
Inventor
Kay Ahn
Markus Boehm
Shawn Cabral
Philip A Carpino
Kentaro Futatsugi
David Hepworth
Daniel W Kung
Suvi Orr
Jian Wang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140468(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CR20140468A publication Critical patent/CR20140468A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
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Abstract

En la presente se describen compuestos de la fórmula I.
CR20140468A 2012-04-06 2014-10-06 Inhibidores de diacilglicerol aciltransferasa 2 CR20140468A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06
PCT/IB2013/052404 WO2013150416A1 (en) 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors

Publications (1)

Publication Number Publication Date
CR20140468A true CR20140468A (es) 2014-11-17

Family

ID=48428540

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140468A CR20140468A (es) 2012-04-06 2014-10-06 Inhibidores de diacilglicerol aciltransferasa 2

Country Status (27)

Country Link
US (1) US9296745B2 (es)
EP (1) EP2834238B1 (es)
JP (1) JP2015515472A (es)
KR (1) KR20140137404A (es)
CN (1) CN104334557A (es)
AP (1) AP2014007953A0 (es)
AU (1) AU2013245353A1 (es)
CA (1) CA2869587A1 (es)
CL (1) CL2014002541A1 (es)
CO (1) CO7160030A2 (es)
CR (1) CR20140468A (es)
CU (1) CU20140115A7 (es)
DO (1) DOP2014000225A (es)
EA (1) EA201400990A1 (es)
EC (1) ECSP14021251A (es)
GT (1) GT201400213A (es)
HK (1) HK1206735A1 (es)
IL (1) IL234928A0 (es)
MA (1) MA37385B1 (es)
MD (1) MD20140103A2 (es)
MX (1) MX2014011373A (es)
NI (1) NI201400120A (es)
PE (1) PE20142164A1 (es)
PH (1) PH12014502057A1 (es)
SG (1) SG11201405477XA (es)
TN (1) TN2014000419A1 (es)
WO (1) WO2013150416A1 (es)

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AU2015233094B2 (en) 2014-03-17 2017-04-27 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
MX385777B (es) * 2014-12-24 2025-03-04 Lg Chemical Ltd Derivado de biarilo como agonista de gpr120.
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US20180312845A1 (en) * 2015-07-10 2018-11-01 Ionis Pharmaceuticals, Inc. Modulators of diacyglycerol acyltransferase 2 (dgat2)
WO2017143011A1 (en) * 2016-02-16 2017-08-24 Chrysalis, Inc. Histone demethylase inhibitors
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
TWI841671B (zh) 2019-01-24 2024-05-11 日商第一三共股份有限公司 具有取代基之脲化合物
TWI771766B (zh) * 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
US20230174521A1 (en) 2020-05-18 2023-06-08 Merck Sharp & Dohme Llc Novel diacylglyceride o-acyltransferase 2 inhibitors
KR20230053645A (ko) 2020-08-19 2023-04-21 브리스톨-마이어스 스큅 컴퍼니 섬유증의 치료를 위한 tlr9 억제제로서의 1h-벤조[d]이미다졸 유도체
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
CN116457346A (zh) 2020-10-08 2023-07-18 默沙东有限责任公司 作为新型二酰基甘油酯o-酰基转移酶2抑制剂的吲哚酮衍生物的制备
CA3195014A1 (en) 2020-10-08 2022-04-14 Yeon-Hee Lim Preparation of benzimidazolone derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
UY39484A (es) * 2020-11-02 2022-06-30 Novartis Ag Inhibidores de interleucina-17
KR20230124989A (ko) 2020-12-22 2023-08-28 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의테트라히드로인다졸 유도체의 제조
US20250066337A1 (en) 2021-08-26 2025-02-27 Pfizer Inc. Amorphous Form of (S)-2-(5-((3-Ethoxypyridin-2-YL)Oxy)Pyridin-3-YL)-N-(Tetrahydrofuran-3-YL)Pyrimidine-5-Carboxamide
MX2024009441A (es) * 2022-02-18 2024-08-14 Bristol Myers Squibb Co Compuestos de imidazopiridinilo sustituidos utiles como inhibidores del receptor tipo toll 9 (tlr9).
GEAP202516792A (en) 2022-12-02 2025-10-10 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
WO2025194014A1 (en) * 2024-03-15 2025-09-18 Dem Biopharma, Inc. Hetero aryl modulators of apmap and uses thereof

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EP2834238B1 (en) 2017-02-01
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WO2013150416A1 (en) 2013-10-10
MD20140103A2 (ro) 2015-01-31
SG11201405477XA (en) 2014-11-27
TN2014000419A1 (fr) 2016-03-30
CA2869587A1 (en) 2013-10-10
MA37385A3 (fr) 2016-12-30
MA201637385A2 (fr) 2016-03-31
EP2834238A1 (en) 2015-02-11
MA37385B1 (fr) 2019-09-30
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HK1206735A1 (en) 2016-01-15
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AP2014007953A0 (en) 2014-09-30
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DOP2014000225A (es) 2014-11-30
AU2013245353A1 (en) 2014-09-25
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US9296745B2 (en) 2016-03-29

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