CL2014002541A1 - Compuestos derivados de imidazol fusionado con heterociclos, como inhibidores de diacilglicerol aciltransferasa 2; composicion farmaceutica que los comprende, util para el tratamiento de diabetes tipo i y ii, enfermedad cardiaca coronaria, artritis, trombosis, alzheimer, entre otras enfermedades. - Google Patents

Compuestos derivados de imidazol fusionado con heterociclos, como inhibidores de diacilglicerol aciltransferasa 2; composicion farmaceutica que los comprende, util para el tratamiento de diabetes tipo i y ii, enfermedad cardiaca coronaria, artritis, trombosis, alzheimer, entre otras enfermedades.

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Publication number
CL2014002541A1
CL2014002541A1 CL2014002541A CL2014002541A CL2014002541A1 CL 2014002541 A1 CL2014002541 A1 CL 2014002541A1 CL 2014002541 A CL2014002541 A CL 2014002541A CL 2014002541 A CL2014002541 A CL 2014002541A CL 2014002541 A1 CL2014002541 A1 CL 2014002541A1
Authority
CL
Chile
Prior art keywords
thrombosis
alzheimer
arthritis
diabetes
inhibitors
Prior art date
Application number
CL2014002541A
Other languages
English (en)
Inventor
Jian Wang
Kay Ahn
Markus Boehm
Shawn Cabral
Philip A Carpino
Kentaro Futatsugi
David Hepworth
Daniel W Kung
Suvi Orr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002541(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CL2014002541A1 publication Critical patent/CL2014002541A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
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  • Biomedical Technology (AREA)
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  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
CL2014002541A 2012-04-06 2014-09-25 Compuestos derivados de imidazol fusionado con heterociclos, como inhibidores de diacilglicerol aciltransferasa 2; composicion farmaceutica que los comprende, util para el tratamiento de diabetes tipo i y ii, enfermedad cardiaca coronaria, artritis, trombosis, alzheimer, entre otras enfermedades. CL2014002541A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06

Publications (1)

Publication Number Publication Date
CL2014002541A1 true CL2014002541A1 (es) 2015-01-16

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ID=48428540

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CL2014002541A CL2014002541A1 (es) 2012-04-06 2014-09-25 Compuestos derivados de imidazol fusionado con heterociclos, como inhibidores de diacilglicerol aciltransferasa 2; composicion farmaceutica que los comprende, util para el tratamiento de diabetes tipo i y ii, enfermedad cardiaca coronaria, artritis, trombosis, alzheimer, entre otras enfermedades.

Country Status (27)

Country Link
US (1) US9296745B2 (es)
EP (1) EP2834238B1 (es)
JP (1) JP2015515472A (es)
KR (1) KR20140137404A (es)
CN (1) CN104334557A (es)
AP (1) AP2014007953A0 (es)
AU (1) AU2013245353A1 (es)
CA (1) CA2869587A1 (es)
CL (1) CL2014002541A1 (es)
CO (1) CO7160030A2 (es)
CR (1) CR20140468A (es)
CU (1) CU20140115A7 (es)
DO (1) DOP2014000225A (es)
EA (1) EA201400990A1 (es)
EC (1) ECSP14021251A (es)
GT (1) GT201400213A (es)
HK (1) HK1206735A1 (es)
IL (1) IL234928A0 (es)
MA (1) MA37385B1 (es)
MD (1) MD20140103A2 (es)
MX (1) MX2014011373A (es)
NI (1) NI201400120A (es)
PE (1) PE20142164A1 (es)
PH (1) PH12014502057A1 (es)
SG (1) SG11201405477XA (es)
TN (1) TN2014000419A1 (es)
WO (1) WO2013150416A1 (es)

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TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
EP4153596A1 (en) 2020-05-18 2023-03-29 Merck Sharp & Dohme LLC Novel diacylglyceride o-acyltransferase 2 inhibitors
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
AR123700A1 (es) 2020-10-08 2023-01-04 Merck Sharp & Dohme Preparación de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
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PH12014502057A1 (en) 2014-12-10
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HK1206735A1 (en) 2016-01-15
ECSP14021251A (es) 2015-09-30
EA201400990A1 (ru) 2015-01-30
EP2834238A1 (en) 2015-02-11
MA201637385A2 (fr) 2016-03-31
MX2014011373A (es) 2014-10-14
MA37385A3 (fr) 2016-12-30
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AU2013245353A1 (en) 2014-09-25
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US9296745B2 (en) 2016-03-29
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