MX2017007874A - Derivado de biarilo como agonista de gpr120. - Google Patents

Derivado de biarilo como agonista de gpr120.

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Publication number
MX2017007874A
MX2017007874A MX2017007874A MX2017007874A MX2017007874A MX 2017007874 A MX2017007874 A MX 2017007874A MX 2017007874 A MX2017007874 A MX 2017007874A MX 2017007874 A MX2017007874 A MX 2017007874A MX 2017007874 A MX2017007874 A MX 2017007874A
Authority
MX
Mexico
Prior art keywords
biaryl derivative
diabetes
chemical formula
gpr120 agonist
same
Prior art date
Application number
MX2017007874A
Other languages
English (en)
Inventor
Yup Paek Seung
Kwan Kim Young
Woo Joo Hyun
Sil Choi Eun
Yun PARK Sang
Wan Kang Seung
Gyu Kim Byung
Seok Lee Chang
Wook Kim Sung
Dae Lee Sang
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of MX2017007874A publication Critical patent/MX2017007874A/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

La presente invención se relaciona a un derivado de biarilo expresado por la fórmula química 1, un método para producir el derivado de biarilo, una composición farmacéutica que comprende el mismo, y uso del mismo, el derivado de biarilo expresado por la fórmula química 1, como un agonista de GPR120, que promueve la generación de GLP-1 en el tracto gastrointestinal, que reduce la resistencia a insulina en el hígado, músculos y los similares de la actividad anti-inflamatoria en el macrófago, células pancreáticas y los similares, y que permite el uso efectivo en la prevención o tratamiento de inflamación o enfermedades metabólicas tales como diabetes, complicaciones de diabetes, obesidad, enfermedad de hígado graso no alcohólico, enfermedad de hígado graso y osteoporosis.
MX2017007874A 2014-12-24 2015-12-23 Derivado de biarilo como agonista de gpr120. MX2017007874A (es)

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PCT/KR2015/014178 WO2016105118A2 (ko) 2014-12-24 2015-12-23 Gpr120 효능제로서의 바이아릴 유도체

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