FR2869611B1 - Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique - Google Patents
Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutiqueInfo
- Publication number
- FR2869611B1 FR2869611B1 FR0404713A FR0404713A FR2869611B1 FR 2869611 B1 FR2869611 B1 FR 2869611B1 FR 0404713 A FR0404713 A FR 0404713A FR 0404713 A FR0404713 A FR 0404713A FR 2869611 B1 FR2869611 B1 FR 2869611B1
- Authority
- FR
- France
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0404713A FR2869611B1 (fr) | 2004-05-03 | 2004-05-03 | Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
AU2005238142A AU2005238142B2 (en) | 2004-05-03 | 2005-04-06 | Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof |
ES05730245T ES2293563T3 (es) | 2004-05-03 | 2005-04-06 | Derivados del acido hexenoico, procesos para su preparacion, composiciones farmaceuticas que los contengan y su aplicacion terapeutica. |
EP05730245A EP1742902B1 (fr) | 2004-05-03 | 2005-04-06 | Derives de l'acide hexenoique, procedes de preparation de ces derives, compositions pharmaceutiques les contenant et applications therapeutiques associees |
PCT/EP2005/003606 WO2005105724A1 (fr) | 2004-05-03 | 2005-04-06 | Derives de l'acide hexenoique, procedes de preparation de ces derives, compositions pharmaceutiques les contenant et applications therapeutiques associees |
JP2007511902A JP4819801B2 (ja) | 2004-05-03 | 2005-04-06 | ヘキセン酸誘導体、その調製方法、それらを含む医薬組成物およびその治療用途 |
CA2565187A CA2565187C (fr) | 2004-05-03 | 2005-04-06 | Derives de l'acide hexenoique, procedes de preparation de ces derives, compositions pharmaceutiques les contenant et applications therapeutiques associees |
DE602005002647T DE602005002647T2 (de) | 2004-05-03 | 2005-04-06 | Hexensäurederivate, verfahren zu deren herstellung, pharmazeutische zusammensetzungen, die diese enthalten, und therapeutische anwendungen davon |
AT05730245T ATE374172T1 (de) | 2004-05-03 | 2005-04-06 | Hexensäurederivate, verfahren zu deren herstellung, pharmazeutische zusammensetzungen, die diese enthalten, und therapeutische anwendungen davon |
US11/579,361 US7632846B2 (en) | 2004-05-03 | 2005-04-06 | Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof |
ARP050101702A AR048717A1 (es) | 2004-05-03 | 2005-04-29 | Derivados de acido hexenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y sus aplicaciones terapeuticas |
US12/507,880 US8063067B2 (en) | 2004-05-03 | 2009-07-23 | Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0404713A FR2869611B1 (fr) | 2004-05-03 | 2004-05-03 | Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2869611A1 FR2869611A1 (fr) | 2005-11-04 |
FR2869611B1 true FR2869611B1 (fr) | 2006-07-28 |
Family
ID=34944690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0404713A Expired - Fee Related FR2869611B1 (fr) | 2004-05-03 | 2004-05-03 | Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
Country Status (11)
Country | Link |
---|---|
US (2) | US7632846B2 (fr) |
EP (1) | EP1742902B1 (fr) |
JP (1) | JP4819801B2 (fr) |
AR (1) | AR048717A1 (fr) |
AT (1) | ATE374172T1 (fr) |
AU (1) | AU2005238142B2 (fr) |
CA (1) | CA2565187C (fr) |
DE (1) | DE602005002647T2 (fr) |
ES (1) | ES2293563T3 (fr) |
FR (1) | FR2869611B1 (fr) |
WO (1) | WO2005105724A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2880887B1 (fr) * | 2005-01-14 | 2009-01-30 | Merck Sante Soc Par Actions Si | Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
AU2007239283B2 (en) * | 2006-04-18 | 2013-02-07 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor delta |
FR2909379B1 (fr) * | 2006-11-30 | 2009-01-16 | Servier Lab | Nouveaux derives heterocycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
EP2125711B1 (fr) | 2007-03-08 | 2013-11-06 | Albireo Ab | Derives de l'acide 3-phenylpropionique et leur utilisation dans le traitement des maladies intestinales inflammatoires |
LT2277874T (lt) * | 2008-04-15 | 2018-10-10 | Nippon Chemiphar Co., Ltd. | Peroksisomų proliferatoriaus aktyvuotų receptorių aktyvatorius |
CA2770494A1 (fr) * | 2009-08-14 | 2011-02-17 | Ronald Barbaras | Utilisation des ligands ppar? dans le traitement ou la prevention d'inflammations ou de maladies associees au metabolisme/production energetique |
KR101307494B1 (ko) * | 2010-07-07 | 2013-09-11 | 주식회사 엘지화학 | 광반응성 작용기를 갖는 화합물, 광반응성 중합체 및 이를 포함하는 배향막 |
CA2912747C (fr) | 2013-06-27 | 2021-05-04 | Lg Life Sciences Ltd. | Derives de biaryle en tant qu'agonistes de gpr120 |
WO2016105118A2 (fr) | 2014-12-24 | 2016-06-30 | 주식회사 엘지생명과학 | Dérivé de biaryle utilisable en tant qu'agoniste du gpr120 |
KR20200092971A (ko) * | 2017-11-15 | 2020-08-04 | 닛뽕 케미파 가부시키가이샤 | 페르옥시솜 증식제 응답성 수용체 활성화제 |
US11730714B2 (en) * | 2017-12-14 | 2023-08-22 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
US11591284B2 (en) | 2017-12-14 | 2023-02-28 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3378582A (en) * | 1964-03-20 | 1968-04-16 | Merck & Co Inc | (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids |
US4335249A (en) * | 1975-09-03 | 1982-06-15 | Rohm And Haas Company | Herbicidal diphenyl ethers, sulfides, sulfoxides and sulfones |
IT1212821B (it) * | 1983-06-03 | 1989-11-30 | Scharper Spa | Derivati dell'acido fenil-etil-acetico ad attivita'antiinfiammatoria. |
FR2869610B1 (fr) * | 2004-05-03 | 2006-07-28 | Merck Sante Soc Par Actions Si | Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques |
-
2004
- 2004-05-03 FR FR0404713A patent/FR2869611B1/fr not_active Expired - Fee Related
-
2005
- 2005-04-06 WO PCT/EP2005/003606 patent/WO2005105724A1/fr active IP Right Grant
- 2005-04-06 JP JP2007511902A patent/JP4819801B2/ja not_active Expired - Fee Related
- 2005-04-06 CA CA2565187A patent/CA2565187C/fr not_active Expired - Fee Related
- 2005-04-06 ES ES05730245T patent/ES2293563T3/es active Active
- 2005-04-06 AT AT05730245T patent/ATE374172T1/de not_active IP Right Cessation
- 2005-04-06 EP EP05730245A patent/EP1742902B1/fr not_active Not-in-force
- 2005-04-06 DE DE602005002647T patent/DE602005002647T2/de active Active
- 2005-04-06 US US11/579,361 patent/US7632846B2/en not_active Expired - Fee Related
- 2005-04-06 AU AU2005238142A patent/AU2005238142B2/en not_active Ceased
- 2005-04-29 AR ARP050101702A patent/AR048717A1/es unknown
-
2009
- 2009-07-23 US US12/507,880 patent/US8063067B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4819801B2 (ja) | 2011-11-24 |
AU2005238142A1 (en) | 2005-11-10 |
FR2869611A1 (fr) | 2005-11-04 |
CA2565187A1 (fr) | 2005-11-10 |
JP2007536290A (ja) | 2007-12-13 |
ES2293563T3 (es) | 2008-03-16 |
AU2005238142B2 (en) | 2011-01-27 |
DE602005002647D1 (de) | 2007-11-08 |
US7632846B2 (en) | 2009-12-15 |
US8063067B2 (en) | 2011-11-22 |
CA2565187C (fr) | 2012-12-18 |
AR048717A1 (es) | 2006-05-17 |
EP1742902A1 (fr) | 2007-01-17 |
US20080194564A1 (en) | 2008-08-14 |
ATE374172T1 (de) | 2007-10-15 |
DE602005002647T2 (de) | 2008-07-17 |
EP1742902B1 (fr) | 2007-09-26 |
WO2005105724A1 (fr) | 2005-11-10 |
US20090286776A1 (en) | 2009-11-19 |
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