FR2836143B1 - Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2836143B1
FR2836143B1 FR0202199A FR0202199A FR2836143B1 FR 2836143 B1 FR2836143 B1 FR 2836143B1 FR 0202199 A FR0202199 A FR 0202199A FR 0202199 A FR0202199 A FR 0202199A FR 2836143 B1 FR2836143 B1 FR 2836143B1
Authority
FR
France
Prior art keywords
amino acid
pharmaceutical compositions
same
preparation process
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0202199A
Other languages
English (en)
Other versions
FR2836143A1 (fr
Inventor
Nanteuil Guillaume De
Philippe Gloanec
Tony Verbeuren
Alain Rupin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0202199A priority Critical patent/FR2836143B1/fr
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to PCT/FR2003/000506 priority patent/WO2003070690A2/fr
Priority to MXPA04007988A priority patent/MXPA04007988A/es
Priority to BR0307776-4A priority patent/BR0307776A/pt
Priority to GEAP8409A priority patent/GEP20074100B/en
Priority to KR1020047013041A priority patent/KR100668194B1/ko
Priority to NZ534359A priority patent/NZ534359A/en
Priority to UA20040907682A priority patent/UA77763C2/uk
Priority to AU2003224198A priority patent/AU2003224198A1/en
Priority to EA200401011A priority patent/EA006389B1/ru
Priority to PL03370817A priority patent/PL370817A1/xx
Priority to CA002474785A priority patent/CA2474785A1/fr
Priority to EP03720618A priority patent/EP1476421A2/fr
Priority to CNB038041189A priority patent/CN1257889C/zh
Priority to JP2003569599A priority patent/JP4106337B2/ja
Priority to US10/505,005 priority patent/US7265220B2/en
Priority to ARP030100563A priority patent/AR038443A1/es
Publication of FR2836143A1 publication Critical patent/FR2836143A1/fr
Application granted granted Critical
Publication of FR2836143B1 publication Critical patent/FR2836143B1/fr
Priority to ZA200406027A priority patent/ZA200406027B/en
Priority to NO20043910A priority patent/NO20043910L/no
Priority to MA27865A priority patent/MA27110A1/fr
Priority to HK05111846A priority patent/HK1079764A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/28—Phenalenes; Hydrogenated phenalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FR0202199A 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2836143B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR0202199A FR2836143B1 (fr) 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003569599A JP4106337B2 (ja) 2002-02-21 2003-02-17 新規なアミノ酸誘導体、その製造方法及び該誘導体を含む薬剤組成物
CNB038041189A CN1257889C (zh) 2002-02-21 2003-02-17 新的氨基酸衍生物、它们的制备方法及含有它们的药物组合物
GEAP8409A GEP20074100B (en) 2002-02-21 2003-02-17 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising the same
MXPA04007988A MXPA04007988A (es) 2002-02-21 2003-02-17 Nuevos derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
NZ534359A NZ534359A (en) 2002-02-21 2003-02-17 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
UA20040907682A UA77763C2 (en) 2002-02-21 2003-02-17 Amino acids derivatives, a process for preparation thereof and pharmaceutical composition containing them
US10/505,005 US7265220B2 (en) 2002-02-21 2003-02-17 Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
EA200401011A EA006389B1 (ru) 2002-02-21 2003-02-17 Новые соединения аминокислоты, способ их получения и фармацевтические композиции, содержащие их
PL03370817A PL370817A1 (en) 2002-02-21 2003-02-17 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
PCT/FR2003/000506 WO2003070690A2 (fr) 2002-02-21 2003-02-17 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP03720618A EP1476421A2 (fr) 2002-02-21 2003-02-17 Nouveaux derives d acides amines, leur procede de preparatio n et les compositions pharmaceutiques qui les contiennent
BR0307776-4A BR0307776A (pt) 2002-02-21 2003-02-17 Derivados de ácidos aminados, o respectivo processo de preparo e as composições farmacêuticas que os contêm
KR1020047013041A KR100668194B1 (ko) 2002-02-21 2003-02-17 아미노산 유도체, 이의 제조 방법 및 이를 포함하는 약제조성물
AU2003224198A AU2003224198A1 (en) 2002-02-21 2003-02-17 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
CA002474785A CA2474785A1 (fr) 2002-02-21 2003-02-17 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ARP030100563A AR038443A1 (es) 2002-02-21 2003-02-21 Derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
ZA200406027A ZA200406027B (en) 2002-02-21 2004-07-28 Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative
NO20043910A NO20043910L (no) 2002-02-21 2004-09-20 Nye aminosyreforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
MA27865A MA27110A1 (fr) 2002-02-21 2004-09-20 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HK05111846A HK1079764A1 (en) 2002-02-21 2005-12-22 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202199A FR2836143B1 (fr) 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2836143A1 FR2836143A1 (fr) 2003-08-22
FR2836143B1 true FR2836143B1 (fr) 2004-04-16

Family

ID=27636380

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0202199A Expired - Fee Related FR2836143B1 (fr) 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (21)

Country Link
US (1) US7265220B2 (fr)
EP (1) EP1476421A2 (fr)
JP (1) JP4106337B2 (fr)
KR (1) KR100668194B1 (fr)
CN (1) CN1257889C (fr)
AR (1) AR038443A1 (fr)
AU (1) AU2003224198A1 (fr)
BR (1) BR0307776A (fr)
CA (1) CA2474785A1 (fr)
EA (1) EA006389B1 (fr)
FR (1) FR2836143B1 (fr)
GE (1) GEP20074100B (fr)
HK (1) HK1079764A1 (fr)
MA (1) MA27110A1 (fr)
MX (1) MXPA04007988A (fr)
NO (1) NO20043910L (fr)
NZ (1) NZ534359A (fr)
PL (1) PL370817A1 (fr)
UA (1) UA77763C2 (fr)
WO (1) WO2003070690A2 (fr)
ZA (1) ZA200406027B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
US9290485B2 (en) * 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
EP3749697A4 (fr) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. Résine de chromatographie ayant un ligand mode mixte échange anionique/hydrophobe
AU2019371209A1 (en) * 2018-10-29 2021-05-27 Huahai Us Inc Novel dipeptide compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69406083T2 (de) 1993-04-28 1998-02-26 Kumiai Chemical Industry Co Aminosäureamide, bakterizide für gartenbau und landwirtschaft sowie herstellungverfahren
JP2001504492A (ja) * 1996-11-19 2001-04-03 ブテナス、 ザウリアス ６―ペプチジルアミノ―１―ナフタレンスルホンアミド・モエッティを含むペプチドミメティック体
AU2300699A (en) * 1998-02-17 1999-08-30 Ono Pharmaceutical Co. Ltd. Amidino derivatives and drugs containing the same as the active ingredient

Also Published As

Publication number Publication date
WO2003070690A2 (fr) 2003-08-28
KR100668194B1 (ko) 2007-01-11
US20050085517A1 (en) 2005-04-21
CA2474785A1 (fr) 2003-08-28
EA200401011A1 (ru) 2004-12-30
WO2003070690A3 (fr) 2004-04-08
JP2005517734A (ja) 2005-06-16
EP1476421A2 (fr) 2004-11-17
NZ534359A (en) 2005-12-23
US7265220B2 (en) 2007-09-04
ZA200406027B (en) 2006-06-28
MA27110A1 (fr) 2004-12-20
FR2836143A1 (fr) 2003-08-22
CN1633412A (zh) 2005-06-29
PL370817A1 (en) 2005-05-30
AR038443A1 (es) 2005-01-12
MXPA04007988A (es) 2004-11-26
GEP20074100B (en) 2007-05-10
KR20040085219A (ko) 2004-10-07
CN1257889C (zh) 2006-05-31
BR0307776A (pt) 2004-12-07
EA006389B1 (ru) 2005-12-29
NO20043910L (no) 2004-09-20
JP4106337B2 (ja) 2008-06-25
HK1079764A1 (en) 2006-04-13
UA77763C2 (en) 2007-01-15
AU2003224198A1 (en) 2003-09-09

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