ZA200406027B - Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative - Google Patents

Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative Download PDF

Info

Publication number
ZA200406027B
ZA200406027B ZA200406027A ZA200406027A ZA200406027B ZA 200406027 B ZA200406027 B ZA 200406027B ZA 200406027 A ZA200406027 A ZA 200406027A ZA 200406027 A ZA200406027 A ZA 200406027A ZA 200406027 B ZA200406027 B ZA 200406027B
Authority
ZA
South Africa
Prior art keywords
formula
group
branched
linear
amino
Prior art date
Application number
ZA200406027A
Other languages
English (en)
Inventor
Guillaume De Nanteuil
Philippe Gloanec
Tony Verbeuren
Alain Rupin
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200406027B publication Critical patent/ZA200406027B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/28—Phenalenes; Hydrogenated phenalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200406027A 2002-02-21 2004-07-28 Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative ZA200406027B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202199A FR2836143B1 (fr) 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA200406027B true ZA200406027B (en) 2006-06-28

Family

ID=27636380

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200406027A ZA200406027B (en) 2002-02-21 2004-07-28 Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative

Country Status (21)

Country Link
US (1) US7265220B2 (fr)
EP (1) EP1476421A2 (fr)
JP (1) JP4106337B2 (fr)
KR (1) KR100668194B1 (fr)
CN (1) CN1257889C (fr)
AR (1) AR038443A1 (fr)
AU (1) AU2003224198A1 (fr)
BR (1) BR0307776A (fr)
CA (1) CA2474785A1 (fr)
EA (1) EA006389B1 (fr)
FR (1) FR2836143B1 (fr)
GE (1) GEP20074100B (fr)
HK (1) HK1079764A1 (fr)
MA (1) MA27110A1 (fr)
MX (1) MXPA04007988A (fr)
NO (1) NO20043910L (fr)
NZ (1) NZ534359A (fr)
PL (1) PL370817A1 (fr)
UA (1) UA77763C2 (fr)
WO (1) WO2003070690A2 (fr)
ZA (1) ZA200406027B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
US9290485B2 (en) * 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
WO2019152977A2 (fr) 2018-02-05 2019-08-08 Bio-Rad Laboratories, Inc. Résine de chromatographie ayant un ligand mode mixte échange anionique/hydrophobe
CN116813691B (zh) * 2018-10-29 2024-04-12 丽珠医药集团股份有限公司 新的二肽类化合物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL175906B1 (pl) * 1993-04-28 1999-03-31 Ihara Chemical Ind Co Pochodne amidów aminokwasów,sposób wytwarzania pochodnych amidów aminokwasów oraz środki grzybobójcze do stosowania w rolnictwie i ogrodnictwie.
AU735722B2 (en) * 1996-11-19 2001-07-12 Saulius Butenas Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties
AU2300699A (en) * 1998-02-17 1999-08-30 Ono Pharmaceutical Co. Ltd. Amidino derivatives and drugs containing the same as the active ingredient

Also Published As

Publication number Publication date
BR0307776A (pt) 2004-12-07
JP4106337B2 (ja) 2008-06-25
PL370817A1 (en) 2005-05-30
GEP20074100B (en) 2007-05-10
EP1476421A2 (fr) 2004-11-17
EA006389B1 (ru) 2005-12-29
FR2836143A1 (fr) 2003-08-22
CA2474785A1 (fr) 2003-08-28
NO20043910L (no) 2004-09-20
CN1257889C (zh) 2006-05-31
WO2003070690A2 (fr) 2003-08-28
AU2003224198A1 (en) 2003-09-09
MXPA04007988A (es) 2004-11-26
US7265220B2 (en) 2007-09-04
UA77763C2 (en) 2007-01-15
FR2836143B1 (fr) 2004-04-16
CN1633412A (zh) 2005-06-29
US20050085517A1 (en) 2005-04-21
KR20040085219A (ko) 2004-10-07
AR038443A1 (es) 2005-01-12
KR100668194B1 (ko) 2007-01-11
MA27110A1 (fr) 2004-12-20
HK1079764A1 (en) 2006-04-13
NZ534359A (en) 2005-12-23
JP2005517734A (ja) 2005-06-16
EA200401011A1 (ru) 2004-12-30
WO2003070690A3 (fr) 2004-04-08

Similar Documents

Publication Publication Date Title
KR100612795B1 (ko) 결정성 에파비렌즈
AU2009202389B2 (en) Perindopril
CA2581674A1 (fr) Inhibiteurs de la indoleamine 2,3-dioxygenase (ido)
JP2002504095A (ja) Ｈｉｖ逆転写酵素阻害剤として有用な４，４−二置換−３，４−ジヒドロ−２（１ｈ）−キナゾリノン
EP0524553A1 (fr) Acylmercaptoalcanoyldipeptides, procédés de leur préparation et leur utilisation thérapeutique
NZ509400A (en) Inhibitors of urokinase and blood vessel formation
DE69127681T2 (de) Neue trizyklische Amino- und Nitro Verbindungen mit ACE-hemmenden Eigenschaften
PL188411B1 (pl) Nowe inhibitory trombiny i ich zastosowanie
AU6094098A (en) Quinoxaline in triple combination with protease inhibitors and reverse transcriptase inhibitors as medicines for treating aids
JPH08109131A (ja) Ｈｉｖプロテアーゼ抑制因子組成物
ZA200406027B (en) Novel amino acid derivatives method for productionthereof and pharmaceutical compositions comprisin g said derivative
EP4043467A1 (fr) Classe de molécules fonctionnelles ciblant des voies de protéolyse, préparation et utilisation associées
WO2007027742A2 (fr) Antagonistes de l'integrine $g(a)2$g(b)1/gpia-iia a petites molecules
US6673772B2 (en) Dipeptide compounds and their use as antiviral agents
EP1049673A1 (fr) Amidines heterocycliques utilisees comme inhibiteurs de la kallicreine
HU203770B (en) Process for producing histidine derivatives and pharmaceutical compositions containing them as active components
KR20080014017A (ko) (5ｚ)-5-(6-퀴녹살리닐메틸리덴)-2-[(2,6-디클로로페닐)아미노]-1,3-티아졸-4(5ｈ)-온
AU779356B2 (en) Novel dipeptide compound and medicinal use thereof
US6649593B1 (en) Modulators of SREBP processing
RU2780249C1 (ru) Применение производного 1,3,5-триазин-2,4-диамина для ингибирования репликации бета-коронавирусов, включая sars-cov-2
US5308841A (en) Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US20090131668A1 (en) 4-oxo-4,6,7,8-Tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
US6451999B2 (en) 1-(3-aminoindazol-5-yl)-3-butyl-cyclic urea useful as a HIV protease inhibitor
RU2780247C1 (ru) ПРИМЕНЕНИЕ ТРИЦИКЛИЧЕСКОГО СЕРУСОДЕРЖАЩЕГО ПРОИЗВОДНОГО 1,2-ДИГИДРОХИНОЛИНА ДЛЯ ИНГИБИРОВАНИЯ РЕПЛИКАЦИИ БЕТА-КОРОНАВИРУСОВ, ВКЛЮЧАЯ SARS-CoV-2
JPH08259532A (ja) ペプチド様化合物又はその薬理的に許容される塩