AR038443A1 - Derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

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Publication number
AR038443A1
AR038443A1 ARP030100563A ARP030100563A AR038443A1 AR 038443 A1 AR038443 A1 AR 038443A1 AR P030100563 A ARP030100563 A AR P030100563A AR P030100563 A ARP030100563 A AR P030100563A AR 038443 A1 AR038443 A1 AR 038443A1
Authority
AR
Argentina
Prior art keywords
branched
linear
group
alkyl
optionally substituted
Prior art date
Application number
ARP030100563A
Other languages
English (en)
Inventor
Philippe Gloaenc
Tony Verbeuren
Nanteuil Guillaume De
Alain Rupin
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR038443A1 publication Critical patent/AR038443A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/28—Phenalenes; Hydrogenated phenalenes

Abstract

Sus isómeros ópticos así como sus sales de adición con un ácido farmacéuticamente aceptable. Medicamentos. Reivindicación 1: Compuesto de fórmula (1) en la cual: R1 representa un grupo arilo, heteroarilo, alquilo C1-6 lineal o ramificado, eventualmente sustituido por uno o varios grupos, idénticos o diferentes, elegidos entre arilo o heteroarilo, o bien R1 representa un grupo de fórmula -(CO)-CR6N7NR8R9 en el cual: R6 representa un átomo de hidrógeno o un grupo elegido entre arilo, heteroarilo, heterocicloalquilo, cicloalquilo C3-8 o alquilo C1-6 lineal o ramificado, eventualmente sustituido por uno o varios grupos, idénticos o diferentes, elegidos entre arilo, heteroarilo, heterocicloalquilo, cicloalquilo C3-8 o carboxi; R7 representa un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado; o bien R6 y R7 forman juntos un grupo cicloalquilo C3-8; R8 representa un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado; y R9 representa un átomo de hidrógeno o un grupo R'9 en el cual R'9 representa un grupo elegido entre: alquilo C1-6 lineal o ramificado, eventualmente sustituido por un grupo arilo, carboxi, alcoxicarbonilo C1-6 lineal o ramificado o carbamoilo, arilo, heteroarilo, o sulfonilo sustituido por un grupo elegido entre cicloalquilo C3-8, heterocicloalquilo, arilo (eventualmente sustituido por un grupo ariloxi o heteroariloxi), o alquilo C1-6 lineal o ramificado, eventualmente sustituido por un grupo arilo, heteroarilo, cicloalquilo C3-8 o heterocicloalquilo; R2 representa un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado; R3 representa un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado, eventualmente sustituido por uno o varios grupos arilo; R4 representa un grupo alquilo C1-6 lineal o ramificado eventualmente sustituido por uno o varios grupos arilo; o bien R3 y R4 forman juntos, con el átomo de carbono que los lleva, un sistema mono, bi- o tricíclico, saturado o insaturado, de 3 a 18 eslabones, que presenta eventualmente uno o varios heteroátomos elegidos entre O, S y N, y eventualmente sustituido por uno o varios grupos idénticos o diferentes, elegidos entre halógeno, alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, hidroxi, trihalogenoalquilo C1-6 lineal o ramificado, amino (sustituido eventualmente por uno o varios grupos alquilo C1-6 lineal o ramificado), o carboxi; n representa 0, 1 o 2; Ar representa un grupo arilo o heteroarilo; R5 representa un grupo elegido entre amino, guanidino, ciano y amidino eventualmente sustituido por un grupo hidroxi o alcoxicarbonilo C1-6 lineal o ramificado; sus isómeros ópticos así como sus sales de adición con un ácido farmacéuticamente aceptable, y se da por entendido que por grupo heterocicloalquilo, se entiende un grupo monocíclico, saturado, de 3 a 8 eslabones, que contiene 1, 2 o 3 heteroátomos elegidos entre oxígeno, nitrógeno o azufre, y se entiende que el heterociclo puede ser eventualmente sustituido por uno o varios grupos, idénticos o diferentes, elegidos entre halógeno, alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, oxo, hidroxi, trihalogenoalquilo C1-6 lineal o ramificado y amino (sustituido eventualmente por uno o varios grupos alquilo C1-6 lineal o ramificado), por un grupo arilo, se entiende fenilo, bifenilo o naftilo, y cada uno de esos grupos está eventualmente sustituido por uno o varios grupos, idénticos o diferentes, elegidos entre halógeno, alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, hidroxi, trihalogenoalquilo C1-6 lineal o ramificado, amino (sustituido eventualmente por uno o varios grupos alquilo C1-6 lineal o ramificado) o carboxi, y por grupo heteroarilo, se entiende un grupo aromático monocíclico o un grupo bicíclico en el cual al menos uno de los ciclos es aromático, compuesto por 5 a 12 eslabones, que contiene 1, 2 o 3 heteroátomos idénticos o diferentes elegidos entre oxígeno, nitrógeno o azufre, y se entiende que el heteroarilo puede ser eventualmente sustituido por uno o varios grupos idénticos o diferentes, elegidos entre halógeno, alquilo C1-6 lineal o ramificado, hidroxi, alcoxi C1-6 lineal o ramificado, trihalógenometilo, y amino (sustituido eventualmente por uno o varios grupos alquilo C1-6 lineal o ramificado).
ARP030100563A 2002-02-21 2003-02-21 Derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen AR038443A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202199A FR2836143B1 (fr) 2002-02-21 2002-02-21 Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
AR038443A1 true AR038443A1 (es) 2005-01-12

Family

ID=27636380

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100563A AR038443A1 (es) 2002-02-21 2003-02-21 Derivados de aminoacidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (21)

Country Link
US (1) US7265220B2 (es)
EP (1) EP1476421A2 (es)
JP (1) JP4106337B2 (es)
KR (1) KR100668194B1 (es)
CN (1) CN1257889C (es)
AR (1) AR038443A1 (es)
AU (1) AU2003224198A1 (es)
BR (1) BR0307776A (es)
CA (1) CA2474785A1 (es)
EA (1) EA006389B1 (es)
FR (1) FR2836143B1 (es)
GE (1) GEP20074100B (es)
HK (1) HK1079764A1 (es)
MA (1) MA27110A1 (es)
MX (1) MXPA04007988A (es)
NO (1) NO20043910L (es)
NZ (1) NZ534359A (es)
PL (1) PL370817A1 (es)
UA (1) UA77763C2 (es)
WO (1) WO2003070690A2 (es)
ZA (1) ZA200406027B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
US9290485B2 (en) * 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
WO2019152977A2 (en) 2018-02-05 2019-08-08 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
KR20210086682A (ko) * 2018-10-29 2021-07-08 화하이 유에스 인코퍼레이티드 신규한 디펩티드 화합물과 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648740B1 (en) 1993-04-28 1997-10-08 Kumiai Chemical Industry Co., Ltd. Amino acid amide derivative, agrohorticultural bactericide, and production process
WO1998022125A1 (en) * 1996-11-19 1998-05-28 Saulius Butenas Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties
US6358960B1 (en) * 1998-02-17 2002-03-19 Ono Pharmaceutical Co., Ltd. Amidino derivatives and drugs containing the same as the active ingredient

Also Published As

Publication number Publication date
US7265220B2 (en) 2007-09-04
JP4106337B2 (ja) 2008-06-25
JP2005517734A (ja) 2005-06-16
US20050085517A1 (en) 2005-04-21
KR100668194B1 (ko) 2007-01-11
KR20040085219A (ko) 2004-10-07
CN1633412A (zh) 2005-06-29
PL370817A1 (en) 2005-05-30
FR2836143B1 (fr) 2004-04-16
FR2836143A1 (fr) 2003-08-22
EA200401011A1 (ru) 2004-12-30
NZ534359A (en) 2005-12-23
GEP20074100B (en) 2007-05-10
AU2003224198A1 (en) 2003-09-09
WO2003070690A2 (fr) 2003-08-28
BR0307776A (pt) 2004-12-07
EA006389B1 (ru) 2005-12-29
HK1079764A1 (en) 2006-04-13
ZA200406027B (en) 2006-06-28
MA27110A1 (fr) 2004-12-20
CN1257889C (zh) 2006-05-31
WO2003070690A3 (fr) 2004-04-08
MXPA04007988A (es) 2004-11-26
CA2474785A1 (fr) 2003-08-28
UA77763C2 (en) 2007-01-15
NO20043910L (no) 2004-09-20
EP1476421A2 (fr) 2004-11-17

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