UY34374A - Benzilindazoles sustituidos - Google Patents

Benzilindazoles sustituidos

Info

Publication number
UY34374A
UY34374A UY0001034374A UY34374A UY34374A UY 34374 A UY34374 A UY 34374A UY 0001034374 A UY0001034374 A UY 0001034374A UY 34374 A UY34374 A UY 34374A UY 34374 A UY34374 A UY 34374A
Authority
UY
Uruguay
Prior art keywords
benzilindazoles
replaced
página
sgdd
escanear
Prior art date
Application number
UY0001034374A
Other languages
English (en)
Inventor
Hans Dr Briem
Volker Dr Schulze
Antje Margret Dr Wengner
Gerhard Dr Siemeister
Philip Dr Lienau
Mark Jean Dr Gnoth
Marion Dr Hitchcock
Anne Dr Mengel
Vera Puetter
Knut Dr Eis
Amaury Ernesto Dr Fernandez-Montalvan
Stefan Dr Prechtl
Simon Dr Holton
Joerg Dr Fanghaenel
Preusse Cornelia
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of UY34374A publication Critical patent/UY34374A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/36—Ericaceae, e.g. azalea, cranberry or blueberry
    • A01H6/368—Vaccinium, e.g. cranberry, blueberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compuestos de la fórmula (I) que son inhibidores de Bub1 quinasa; procesos para su producción y su uso como fármacos.
UY0001034374A 2011-10-06 2012-10-05 Benzilindazoles sustituidos UY34374A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11184061 2011-10-06

Publications (1)

Publication Number Publication Date
UY34374A true UY34374A (es) 2013-05-31

Family

ID=46968229

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034374A UY34374A (es) 2011-10-06 2012-10-05 Benzilindazoles sustituidos

Country Status (38)

Country Link
US (3) US20140249133A1 (es)
EP (1) EP2763982B1 (es)
JP (1) JP6140170B2 (es)
KR (1) KR102007056B1 (es)
CN (1) CN103974948B (es)
AP (1) AP3847A (es)
AR (1) AR088449A1 (es)
AU (1) AU2012320582B2 (es)
BR (1) BR112014008045A2 (es)
CA (1) CA2851037A1 (es)
CO (1) CO6930363A2 (es)
CR (1) CR20140161A (es)
CU (1) CU20140043A7 (es)
CY (1) CY1120318T1 (es)
DK (1) DK2763982T3 (es)
DO (1) DOP2014000062A (es)
EA (1) EA201400412A1 (es)
EC (1) ECSP14013284A (es)
ES (1) ES2665036T3 (es)
GT (1) GT201400063A (es)
HK (1) HK1200449A1 (es)
HR (1) HRP20180546T1 (es)
HU (1) HUE037154T2 (es)
IL (1) IL231591A (es)
LT (1) LT2763982T (es)
MX (1) MX361279B (es)
NO (1) NO2763982T3 (es)
PE (1) PE20141203A1 (es)
PL (1) PL2763982T3 (es)
PT (1) PT2763982T (es)
RS (1) RS57099B1 (es)
SG (1) SG11201400616YA (es)
SI (1) SI2763982T1 (es)
TN (1) TN2014000138A1 (es)
TW (1) TWI588141B (es)
UA (1) UA111754C2 (es)
UY (1) UY34374A (es)
WO (1) WO2013050438A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA111754C2 (uk) 2011-10-06 2016-06-10 Байєр Фарма Акцієнгезелльшафт Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань
WO2013092512A1 (en) 2011-12-21 2013-06-27 Bayer Intellectual Property Gmbh Substituted benzylpyrazoles
JP2015520143A (ja) * 2012-05-11 2015-07-16 バイエル ファーマ アクチエンゲゼルシャフト 癌を治療するためのｂｕｂ１阻害薬としての置換されているシクロアルケノピラゾール類
JP2016514719A (ja) * 2013-03-21 2016-05-23 バイエル ファーマ アクチエンゲゼルシャフト ヘテロアリール置換インダゾール
JP2016514717A (ja) * 2013-03-21 2016-05-23 バイエル ファーマ アクチエンゲゼルシャフト ジアミノヘテロアリール置換インダゾール
CN105209455A (zh) * 2013-03-21 2015-12-30 拜耳制药股份公司 3-杂芳基取代的吲唑
CN105452236A (zh) * 2013-06-21 2016-03-30 拜耳制药股份公司 取代的苄基吡唑
EP3010911A1 (en) * 2013-06-21 2016-04-27 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
CN105408324A (zh) * 2013-06-21 2016-03-16 拜耳制药股份公司 取代的苄基吡唑
US9745285B2 (en) 2013-06-21 2017-08-29 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
EP3010907A1 (en) * 2013-06-21 2016-04-27 Bayer Pharma Aktiengesellschaft Diaminoheteroaryl substituted pyrazoles
CA2928998A1 (en) 2013-10-30 2015-05-07 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
JP6545199B2 (ja) * 2014-06-17 2019-07-17 バイエル ファーマ アクチエンゲゼルシャフト ３−アミノ−１，５，６，７−テトラヒドロ−４ｈ−インドール−４−オン類
BR112017005444A2 (pt) * 2014-09-19 2018-04-24 Bayer Pharma AG indazoles substituídos por benzil como inibidores bub1.
CN107148420A (zh) * 2014-09-19 2017-09-08 拜耳制药股份公司 苄基取代的吲唑类化合物
EP3194381A1 (en) * 2014-09-19 2017-07-26 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 kinase inhibitors
US20170305882A1 (en) * 2014-09-19 2017-10-26 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 kinase inhibitors
GB201419264D0 (en) * 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
CU20170094A7 (es) 2015-01-28 2017-12-08 Bayer Pharma AG Derivados de 4h-pirrol[3,2-c]piridin-4-0na
PL3307734T3 (pl) * 2015-06-09 2020-05-18 Abbvie Inc. Modulatory receptora jądrowego (ror) do leczenia stanu zapalnego i chorób autoimmunologicznych
JP2018522847A (ja) 2015-06-17 2018-08-16 バイエル ファーマ アクチエンゲゼルシャフト ３−アミノ−１，５，６，７−テトラヒドロ−４ｈ−インドール−４−オン類
CA3008393A1 (en) * 2015-12-16 2017-06-22 Bayer Pharma Aktiengesellschaft Hetero-1,5,6,7-tetrahydro-4h-indol-4-ones
WO2017148995A1 (en) 2016-03-04 2017-09-08 Bayer Pharma Aktiengesellschaft 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity
WO2017157992A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders
WO2017157991A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases
WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
WO2018158175A1 (en) 2017-02-28 2018-09-07 Bayer Pharma Aktiengesellschaft Combination of bub1 inhibitors
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors
KR102048050B1 (ko) * 2019-08-29 2020-01-22 대한민국 Adb-푸비나카의 대사체 합성 방법
CN110684016A (zh) * 2019-09-27 2020-01-14 上海应用技术大学 一种含氟的azd9291衍生物及其制备方法和应用
IL301532A (en) 2020-09-23 2023-05-01 Scorpion Therapeutics Inc History Pyrrolo[2,3-C]pyridin-4-one is useful in cancer treatment
WO2022072634A1 (en) 2020-09-30 2022-04-07 Scorpion Therapeutics, Inc. Bicyclic compounds for use in the treatment cancer
WO2022072645A2 (en) 2020-09-30 2022-04-07 Scorpion Therapeutics, Inc. Methods for treating cancer
WO2022094271A1 (en) 2020-10-30 2022-05-05 Scorpion Therapeutics, Inc. Methods for treating cancer
WO2022098992A1 (en) 2020-11-05 2022-05-12 Scorpion Therapeutics, Inc. Use of macrocyclic compounds in methods of treating cancer
WO2022197913A1 (en) 2021-03-18 2022-09-22 Scorpion Therapeutics, Inc. Bicyclic derivatives which can be used to treat cancer
WO2023173083A1 (en) 2022-03-11 2023-09-14 Scorpion Therapeutics, Inc. Tetrahydroindole derivatives as egfr and/or her2 inhibtors useful for the treatment of cancer

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5470862A (en) 1995-02-03 1995-11-28 Ohmeda Pharmaceutical Products Division Inc. Substituted pyrazolyl compounds and methods employing such compounds
BR9712523A (pt) 1996-10-14 2000-05-09 Bayer Ag Novos derivados de pirazol heterociclilmetil-substituìdos
DE19834047A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19846514A1 (de) * 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
US7569592B2 (en) 2001-12-18 2009-08-04 Merck & Co., Inc. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
US7166293B2 (en) 2002-03-29 2007-01-23 Carlsbad Technology, Inc. Angiogenesis inhibitors
US20040132730A1 (en) 2002-09-10 2004-07-08 Jonathan Axon Inhibitors of TGFbeta
DE10244810A1 (de) 2002-09-26 2004-04-08 Bayer Ag Neue Morpholin-überbrückte Indazolderivate
US8748601B2 (en) 2003-04-11 2014-06-10 The Regents Of The University Of California Selective serine/threonine kinase inhibitors
CA2553513A1 (en) 2004-01-22 2005-08-04 Altana Pharma Ag N-4-(6- (heteo) aryl-pyrimidin-4-ylaminophenyl) -bezenesulfonamides as kinase inhibitors
WO2007065010A2 (en) * 2005-12-02 2007-06-07 Hif Bio, Inc. Anti-angiogenesis compounds
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
RU2009146851A (ru) 2007-05-18 2011-06-27 Байер Шеринг Фарма Акциенгезельшафт (DE) Гетероарил-замещенные пиразольные производные, которые могут использоваться для лечения гиперпролиферативных нарушений и заболеваний, связанных с ангиогенезом
JP2010111624A (ja) * 2008-11-06 2010-05-20 Shionogi & Co Ltd Ｔｔｋ阻害作用を有するインダゾール誘導体
WO2010069966A1 (en) 2008-12-18 2010-06-24 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
CN102666537A (zh) 2009-10-20 2012-09-12 艾格尔生物制药股份有限公司 治疗黄病毒科病毒感染的氮杂吲唑
PT2604608E (pt) 2009-11-27 2015-11-26 Adverio Pharma Gmbh Processo para a preparação de metil-{4,6-diamino-2-[1-(2- fluorobenzil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5- il}metilcarbamato e sua purificação para a utilização como princípio ativo farmacêutico
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CA2829790C (en) 2010-03-30 2018-06-05 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
AR088020A1 (es) 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
UA111754C2 (uk) * 2011-10-06 2016-06-10 Байєр Фарма Акцієнгезелльшафт Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань
WO2013092512A1 (en) 2011-12-21 2013-06-27 Bayer Intellectual Property Gmbh Substituted benzylpyrazoles
WO2013101830A1 (en) 2011-12-27 2013-07-04 Ironwood Pharmaceuticals, Inc. 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators
JP2015520143A (ja) 2012-05-11 2015-07-16 バイエル ファーマ アクチエンゲゼルシャフト 癌を治療するためのｂｕｂ１阻害薬としての置換されているシクロアルケノピラゾール類
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9487508B2 (en) 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
WO2014047662A2 (en) 2012-09-24 2014-03-27 Whitehead Institute For Biomedical Research Indazole derivatives and uses thereof
JP2016514719A (ja) 2013-03-21 2016-05-23 バイエル ファーマ アクチエンゲゼルシャフト ヘテロアリール置換インダゾール
JP2016514717A (ja) 2013-03-21 2016-05-23 バイエル ファーマ アクチエンゲゼルシャフト ジアミノヘテロアリール置換インダゾール
CN105209455A (zh) 2013-03-21 2015-12-30 拜耳制药股份公司 3-杂芳基取代的吲唑
US9745285B2 (en) 2013-06-21 2017-08-29 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
CN105408324A (zh) 2013-06-21 2016-03-16 拜耳制药股份公司 取代的苄基吡唑
EP3010907A1 (en) 2013-06-21 2016-04-27 Bayer Pharma Aktiengesellschaft Diaminoheteroaryl substituted pyrazoles
EP3010911A1 (en) 2013-06-21 2016-04-27 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
CN105452236A (zh) 2013-06-21 2016-03-30 拜耳制药股份公司 取代的苄基吡唑
CA2928998A1 (en) 2013-10-30 2015-05-07 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles
BR112017005444A2 (pt) 2014-09-19 2018-04-24 Bayer Pharma AG indazoles substituídos por benzil como inibidores bub1.
US20170305882A1 (en) 2014-09-19 2017-10-26 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 kinase inhibitors
EP3194381A1 (en) 2014-09-19 2017-07-26 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as bub1 kinase inhibitors
CN107148420A (zh) 2014-09-19 2017-09-08 拜耳制药股份公司 苄基取代的吲唑类化合物
WO2017148995A1 (en) 2016-03-04 2017-09-08 Bayer Pharma Aktiengesellschaft 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity
WO2017157992A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders
WO2017157991A1 (en) 2016-03-18 2017-09-21 Bayer Pharma Aktiengesellschaft 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases
WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
WO2018158175A1 (en) 2017-02-28 2018-09-07 Bayer Pharma Aktiengesellschaft Combination of bub1 inhibitors
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors

Also Published As

Publication number Publication date
HRP20180546T1 (hr) 2018-05-04
US10604532B2 (en) 2020-03-31
LT2763982T (lt) 2018-04-25
CY1120318T1 (el) 2019-07-10
MX361279B (es) 2018-12-03
CA2851037A1 (en) 2013-04-11
US20140249133A1 (en) 2014-09-04
IL231591A (en) 2016-09-29
EA201400412A1 (ru) 2014-08-29
CN103974948A (zh) 2014-08-06
RS57099B1 (sr) 2018-06-29
WO2013050438A1 (en) 2013-04-11
ES2665036T3 (es) 2018-04-24
US10266548B2 (en) 2019-04-23
CU20140043A7 (es) 2014-08-28
SG11201400616YA (en) 2014-09-26
KR102007056B1 (ko) 2019-08-02
AU2012320582B2 (en) 2017-06-15
MX2014004122A (es) 2014-06-04
EP2763982B1 (en) 2018-01-10
US20170260198A1 (en) 2017-09-14
TW201321370A (zh) 2013-06-01
UA111754C2 (uk) 2016-06-10
PL2763982T3 (pl) 2018-07-31
AP3847A (en) 2016-09-30
AR088449A1 (es) 2014-06-11
CN103974948B (zh) 2017-07-28
CO6930363A2 (es) 2014-04-28
PE20141203A1 (es) 2014-10-01
NO2763982T3 (es) 2018-06-09
NZ623098A (en) 2016-09-30
IL231591A0 (en) 2014-05-28
DK2763982T3 (en) 2018-04-23
AU2012320582A1 (en) 2014-04-17
AP2014007533A0 (en) 2014-03-31
SI2763982T1 (en) 2018-06-29
CR20140161A (es) 2014-06-03
GT201400063A (es) 2015-12-07
TN2014000138A1 (en) 2015-09-30
ECSP14013284A (es) 2014-05-31
TWI588141B (zh) 2017-06-21
JP6140170B2 (ja) 2017-05-31
BR112014008045A2 (pt) 2017-04-11
HUE037154T2 (hu) 2018-08-28
PT2763982T (pt) 2018-04-16
EP2763982A1 (en) 2014-08-13
US20190284206A1 (en) 2019-09-19
HK1200449A1 (en) 2015-08-07
KR20140075775A (ko) 2014-06-19
JP2014531465A (ja) 2014-11-27
DOP2014000062A (es) 2014-07-15

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