UY34117A - Derivados de polimixina útiles como agentes antibacterianos - Google Patents

Derivados de polimixina útiles como agentes antibacterianos

Info

Publication number
UY34117A
UY34117A UY0001034117A UY34117A UY34117A UY 34117 A UY34117 A UY 34117A UY 0001034117 A UY0001034117 A UY 0001034117A UY 34117 A UY34117 A UY 34117A UY 34117 A UY34117 A UY 34117A
Authority
UY
Uruguay
Prior art keywords
polymixin
derivatives
useful
antibacterial agents
antibacterial
Prior art date
Application number
UY0001034117A
Other languages
English (en)
Inventor
Jinshan Michael Chen
Zhengong B Li
Thomas Victor Magee
Carlos Alberto Martinez
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY34117A publication Critical patent/UY34117A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona una nueva clase de derivados de polimixina útiles para tratar infecciones bacterianas, en especial infecciones gramnegativas, que tienen reducida citotoxicidad renal.
UY0001034117A 2011-06-08 2012-06-06 Derivados de polimixina útiles como agentes antibacterianos UY34117A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161494645P 2011-06-08 2011-06-08

Publications (1)

Publication Number Publication Date
UY34117A true UY34117A (es) 2013-01-31

Family

ID=46395656

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034117A UY34117A (es) 2011-06-08 2012-06-06 Derivados de polimixina útiles como agentes antibacterianos

Country Status (5)

Country Link
US (1) US20120316105A1 (es)
AR (1) AR086864A1 (es)
TW (1) TW201311729A (es)
UY (1) UY34117A (es)
WO (1) WO2012168820A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物
JP6316846B2 (ja) 2013-01-11 2018-04-25 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ ポリミキシン含有組成物
EP2999711B1 (en) * 2013-05-22 2022-06-29 Spero Therapeutics, Inc. Polymyxin derivatives and their use in combination therapy together with different antibiotics
LT3116897T (lt) * 2014-03-11 2022-05-10 Spero Therapeutics, Inc. Polimiksino dariniai ir jų panaudojimas kompleksinėje terapijoje kartu su skirtingais antibiotikais
CA2944550C (en) 2014-04-01 2021-05-25 Monash University Polymyxin derivatives as antimicrobial compounds
AU2015286956A1 (en) 2014-07-09 2016-12-08 Xellia Pharmaceuticals Aps Low substituted polymyxins and compositions thereof
RU2702335C2 (ru) 2014-10-03 2019-10-08 Кселлия Фармасьютикалз Апс Ингаляционное устройство
CA2961700C (en) * 2014-10-03 2023-03-07 Xellia Pharmaceuticals Aps Aqueous solution of colistimethate sodium
JP7349773B2 (ja) * 2014-11-26 2023-09-25 スペロ・セラピューティクス・インコーポレーテッド 化合物
EP3233889B1 (en) 2014-12-16 2022-07-06 Shanghai MicuRx Pharmaceutical Co., Ltd. Antimicrobial polymyxins for treatment of bacterial infections
NZ741027A (en) * 2015-09-29 2024-05-31 Monash Univ Antimicrobial polymyxin derivative compounds
US20190315806A1 (en) * 2016-12-16 2019-10-17 Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences Polymyxin derivative, preparation method and application thereof
AU2018359018B2 (en) 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
SI3810633T1 (sl) * 2018-06-25 2024-04-30 Spero Therapeutics, Inc. Spojine
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
US8193148B2 (en) * 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) * 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.

Also Published As

Publication number Publication date
US20120316105A1 (en) 2012-12-13
AR086864A1 (es) 2014-01-29
WO2012168820A1 (en) 2012-12-13
TW201311729A (zh) 2013-03-16

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20201020