AR086864A1 - Derivados de polimixina utiles como agentes antibacterianos - Google Patents
Derivados de polimixina utiles como agentes antibacterianosInfo
- Publication number
- AR086864A1 AR086864A1 ARP120102028A ARP120102028A AR086864A1 AR 086864 A1 AR086864 A1 AR 086864A1 AR P120102028 A ARP120102028 A AR P120102028A AR P120102028 A ARP120102028 A AR P120102028A AR 086864 A1 AR086864 A1 AR 086864A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- useful
- polymixin
- derivatives
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Una clase de derivados de polimixina útiles para tratar infecciones bacterianas, en especial infecciones gramnegativas, que tienen reducida citotoxicidad renal.Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) o una de sus sales farmacéuticamente aceptables, donde L1 es un enlace, carbonilo, sulfonilo, -NHC(O)-, o -OC(O)-; R1 es alquilo C1-10, arilo C6-10, aril C6-10alquenilo C2-4, heteroarilo C5-12, o heteroarilo C5-12alquenilo C2-4; L2 está ausente, un enlace, -(CH2)n-, -(CH2)nO(CH2)p-, -(CH2)nS(CH2)p-, o -(CH2)nNR3(CH2)p-; R2 está ausente, arilo C6-10, o heteroarilo C5-12; R3 es H o alquilo C1-3; R4 es alquilo C1-6 o aril C6-10alquilo C1-6; R5 es H o CH3; R6 es H o CH3; donde R6 es H cuando R5 es CH3 y donde R6 es CH3 cuando R5 es H; R7 es H o CH3; n es 0, 1, 2, ó 3; y p es 0, 1, 2, ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494645P | 2011-06-08 | 2011-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086864A1 true AR086864A1 (es) | 2014-01-29 |
Family
ID=46395656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102028A AR086864A1 (es) | 2011-06-08 | 2012-06-07 | Derivados de polimixina utiles como agentes antibacterianos |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120316105A1 (es) |
| AR (1) | AR086864A1 (es) |
| TW (1) | TW201311729A (es) |
| UY (1) | UY34117A (es) |
| WO (1) | WO2012168820A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103946233A (zh) * | 2011-11-18 | 2014-07-23 | 诺瓦克塔生物系统有限公司 | 多黏菌素衍生物 |
| JP6316846B2 (ja) | 2013-01-11 | 2018-04-25 | クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ | ポリミキシン含有組成物 |
| EP2999711B1 (en) * | 2013-05-22 | 2022-06-29 | Spero Therapeutics, Inc. | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
| LT3116897T (lt) * | 2014-03-11 | 2022-05-10 | Spero Therapeutics, Inc. | Polimiksino dariniai ir jų panaudojimas kompleksinėje terapijoje kartu su skirtingais antibiotikais |
| CA2944550C (en) | 2014-04-01 | 2021-05-25 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| AU2015286956A1 (en) | 2014-07-09 | 2016-12-08 | Xellia Pharmaceuticals Aps | Low substituted polymyxins and compositions thereof |
| RU2702335C2 (ru) | 2014-10-03 | 2019-10-08 | Кселлия Фармасьютикалз Апс | Ингаляционное устройство |
| CA2961700C (en) * | 2014-10-03 | 2023-03-07 | Xellia Pharmaceuticals Aps | Aqueous solution of colistimethate sodium |
| JP7349773B2 (ja) * | 2014-11-26 | 2023-09-25 | スペロ・セラピューティクス・インコーポレーテッド | 化合物 |
| EP3233889B1 (en) | 2014-12-16 | 2022-07-06 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Antimicrobial polymyxins for treatment of bacterial infections |
| NZ741027A (en) * | 2015-09-29 | 2024-05-31 | Monash Univ | Antimicrobial polymyxin derivative compounds |
| US20190315806A1 (en) * | 2016-12-16 | 2019-10-17 | Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences | Polymyxin derivative, preparation method and application thereof |
| AU2018359018B2 (en) | 2017-11-02 | 2022-11-24 | The University Of Queensland | Peptide antibiotics |
| SI3810633T1 (sl) * | 2018-06-25 | 2024-04-30 | Spero Therapeutics, Inc. | Spojine |
| CN111254091B (zh) * | 2020-01-20 | 2022-04-19 | 浙江工业大学 | 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用 |
| CN115298198A (zh) | 2020-01-21 | 2022-11-04 | 上海盟科药业股份有限公司 | 用于肾相关癌症靶向治疗的新型化合物和组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| US8193148B2 (en) * | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| ES2334547B1 (es) * | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
-
2012
- 2012-05-25 WO PCT/IB2012/052644 patent/WO2012168820A1/en active Application Filing
- 2012-06-05 TW TW101120119A patent/TW201311729A/zh unknown
- 2012-06-06 UY UY0001034117A patent/UY34117A/es not_active Application Discontinuation
- 2012-06-07 US US13/490,887 patent/US20120316105A1/en not_active Abandoned
- 2012-06-07 AR ARP120102028A patent/AR086864A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY34117A (es) | 2013-01-31 |
| US20120316105A1 (en) | 2012-12-13 |
| WO2012168820A1 (en) | 2012-12-13 |
| TW201311729A (zh) | 2013-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |