TR201904327T4 - Dimetilbenzoik asit bileşikleri. - Google Patents

Dimetilbenzoik asit bileşikleri. Download PDF

Info

Publication number
TR201904327T4
TR201904327T4 TR2019/04327T TR201904327T TR201904327T4 TR 201904327 T4 TR201904327 T4 TR 201904327T4 TR 2019/04327 T TR2019/04327 T TR 2019/04327T TR 201904327 T TR201904327 T TR 201904327T TR 201904327 T4 TR201904327 T4 TR 201904327T4
Authority
TR
Turkey
Prior art keywords
acid compounds
dimethylbenzoic acid
dimethylbenzoic
receptor
inhibitor
Prior art date
Application number
TR2019/04327T
Other languages
English (en)
Inventor
Blanco-Pillado Maria-Jesus
Rudolph Manninen Peter
Allen Schiffler Matthew
Natali Vetman Tatiana
M Warshawsky Alan
Schulenburg York Jeremy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TR201904327T4 publication Critical patent/TR201904327T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mevcut buluşta, EP4 reseptörünün bir inhibitörü olarak kullanım için Formül I'in bir bileşiği veya onun farmasötik açıdan kabul edilebilir bir tuzu sağlanmakta olup, burada A, :'dir ve W, Y, X, R1, R2, R3 ve R4 burada tanımlandığı gibidir.
TR2019/04327T 2013-12-17 2014-12-11 Dimetilbenzoik asit bileşikleri. TR201904327T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361916824P 2013-12-17 2013-12-17

Publications (1)

Publication Number Publication Date
TR201904327T4 true TR201904327T4 (tr) 2019-04-22

Family

ID=52355186

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/04327T TR201904327T4 (tr) 2013-12-17 2014-12-11 Dimetilbenzoik asit bileşikleri.

Country Status (23)

Country Link
US (1) US10005721B2 (tr)
EP (1) EP3083554B1 (tr)
JP (1) JP6200596B2 (tr)
KR (1) KR101937186B1 (tr)
CN (1) CN105793236B (tr)
AU (1) AU2014366371B2 (tr)
CA (1) CA2929562A1 (tr)
CY (1) CY1121677T1 (tr)
DK (1) DK3083554T3 (tr)
EA (1) EA028675B1 (tr)
ES (1) ES2727329T3 (tr)
HR (1) HRP20190793T1 (tr)
HU (1) HUE043614T2 (tr)
LT (1) LT3083554T (tr)
ME (1) ME03398B (tr)
MX (1) MX368178B (tr)
PL (1) PL3083554T3 (tr)
PT (1) PT3083554T (tr)
RS (1) RS58594B1 (tr)
SA (1) SA516371324B1 (tr)
SI (1) SI3083554T1 (tr)
TR (1) TR201904327T4 (tr)
WO (1) WO2015094912A1 (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2960324A1 (en) 2014-09-09 2016-03-17 Bayer Pharma Aktiengesellschaft Substituted n,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents
US10745382B2 (en) * 2015-10-15 2020-08-18 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2017153235A1 (de) * 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung
TWI770157B (zh) 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
JP7107963B2 (ja) 2017-04-10 2022-07-27 バイエル・アクチエンゲゼルシヤフト 置換されたｎ－アリールエチル－２－アリールキノリン－４－カルボキサミド類及びそれの使用
CA3060597A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
ES2929309T3 (es) 2017-05-18 2022-11-28 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor PGE2
EP3625228B1 (en) 2017-05-18 2021-07-07 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as pge2 receptor modulators
AU2018269667B2 (en) 2017-05-18 2022-02-03 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
EP3889134A4 (en) * 2019-01-22 2022-02-16 Keythera (Suzhou) Pharmaceuticals Co. Ltd. COMPOUND INHIBITING PGE2/EP4 SIGNAL TRANSDUCTION, METHOD FOR PREPARATION AND THERAPEUTIC APPLICATIONS
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
TW502026B (en) * 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
ES2246830T3 (es) * 1999-03-17 2006-03-01 Astrazeneca Ab Derivados de amida.
CA2536870C (en) * 2003-09-03 2009-10-27 Pfizer Inc. Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
ES2317052T3 (es) 2003-09-22 2009-04-16 Euro-Celtique S.A. Agentes terapeuticos utiles para el tratamiento del dolor.
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US7326732B2 (en) 2004-02-12 2008-02-05 Pharmagene Laboratories Limited EP2 receptor agonists
JP4054369B2 (ja) * 2004-05-04 2008-02-27 ファイザー株式会社 オルト置換アリールまたはヘテロアリールアミド化合物
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
AU2007260529B2 (en) * 2006-06-12 2012-04-19 Merck Canada Inc. Indoline amide derivatives as EP4 receptor ligands
CA2692265A1 (en) * 2007-07-03 2009-01-08 Astellas Pharma Inc. Amide compounds
WO2010043592A1 (en) 2008-10-15 2010-04-22 Revotar Biopharmaceuticals Ag Lipase inhibitors for use for the treatment of obesity
NZ594195A (en) * 2009-01-30 2013-04-26 Toyama Chemical Co Ltd N-acyl anthranilic acid derivative or salt thereof
EP2607348B8 (en) * 2009-03-31 2021-04-21 Renascience Inc. Plasminogen Activator Inhibitor-1 Inhibitor
WO2012004293A2 (de) 2010-07-08 2012-01-12 Bayer Cropscience Ag Insektizide und fungizide wirkstoffkombinationen
WO2012117097A1 (en) 2011-03-03 2012-09-07 Universität des Saarlandes Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors
SG11201400117QA (en) * 2011-08-31 2014-03-28 Amakem Nv Novel soft rock inhibitors
CA2848229C (en) * 2011-09-16 2019-08-27 Fovea Pharmaceuticals Aniline derivatives, their preparation and their therapeutic application
TWI572597B (zh) 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基－苯甲酸化合物
EP2765128A1 (en) * 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors

Also Published As

Publication number Publication date
CA2929562A1 (en) 2015-06-25
RS58594B1 (sr) 2019-05-31
ES2727329T3 (es) 2019-10-15
LT3083554T (lt) 2019-05-10
AU2014366371A1 (en) 2016-05-19
EA028675B1 (ru) 2017-12-29
SI3083554T1 (sl) 2019-04-30
EA201690911A1 (ru) 2016-09-30
MX2016007861A (es) 2017-01-11
KR101937186B1 (ko) 2019-01-10
CN105793236A (zh) 2016-07-20
AU2014366371B2 (en) 2017-02-16
US20160251306A1 (en) 2016-09-01
KR20160086905A (ko) 2016-07-20
MX368178B (es) 2019-09-23
JP2017500309A (ja) 2017-01-05
HUE043614T2 (hu) 2019-08-28
EP3083554B1 (en) 2019-03-13
WO2015094912A1 (en) 2015-06-25
EP3083554A1 (en) 2016-10-26
HRP20190793T1 (hr) 2019-06-28
JP6200596B2 (ja) 2017-09-20
ME03398B (me) 2020-01-20
CN105793236B (zh) 2017-10-10
SA516371324B1 (ar) 2018-03-22
PT3083554T (pt) 2019-06-11
DK3083554T3 (da) 2019-05-13
PL3083554T3 (pl) 2019-08-30
CY1121677T1 (el) 2020-07-31
US10005721B2 (en) 2018-06-26

Similar Documents

Publication Publication Date Title
TR201904327T4 (tr) Dimetilbenzoik asit bileşikleri.
CY1120635T1 (el) Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης
RS54526B1 (en) USE OF PIRAZOLOSPIROKETONE DERIVATIVES AS ACETYL-COA CARBOXYLASE INHIBITORS
EA201690223A1 (ru) Ингибиторы фактора в комплемента на основе производных пиперидинилиндола и их применение
EA201591503A1 (ru) Производные нафтиридина, полезные в качестве антагонистов альфа-v-бета-6 интегрина
MA38050B1 (fr) Inhibiteurs de gdf-8
RS54730B1 (sr) Inhibitori beta sekretaze
EA201590224A1 (ru) Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы
TR201810944T4 (tr) Fgfr4 inhibitörleri olarak halka-füzyonlu bisiklik piridil türevleri.
EA201391239A1 (ru) Пирроло[2,3-d]пиримидиновые производные в качестве ингибиторов тропомиозин-связанных киназ
ATE542813T1 (de) 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
RS54207B1 (en) CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS
EA201691119A1 (ru) Производные мочевины или их фармакологически приемлемые соли
JO3318B1 (ar) مثبطات bace
MA38583A1 (fr) Dérivés de dolastatine 10 et d'auristatines
PH12015501752B1 (en) Substituted bisphenyl butanoic phosphonic acid derivatives as nep inhibitors
EA201690894A1 (ru) Феноксиэтилы
EA201400822A1 (ru) Производные гетероциклических амидов в качестве антагонистов p2xрецептора
TR201902057T4 (tr) Tetrasiklin bileşikleri.
RS54716B1 (en) HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
EA201591915A1 (ru) Соединения феноксиэтил дигидро-1h-изохинолина
UA113086C2 (xx) Піразольні сполуки як інгібітори sglt1
EA201600123A1 (ru) Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона
MX359399B (es) Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
WO2014160177A3 (en) Quinazoline inhibitors of pi3k