EA201591915A1 - Соединения феноксиэтил дигидро-1h-изохинолина - Google Patents

Соединения феноксиэтил дигидро-1h-изохинолина

Info

Publication number
EA201591915A1
EA201591915A1 EA201591915A EA201591915A EA201591915A1 EA 201591915 A1 EA201591915 A1 EA 201591915A1 EA 201591915 A EA201591915 A EA 201591915A EA 201591915 A EA201591915 A EA 201591915A EA 201591915 A1 EA201591915 A1 EA 201591915A1
Authority
EA
Eurasian Patent Office
Prior art keywords
izohinolina
compounds
phenoxyethyl
dihydro
phenoxyethyl dihydro
Prior art date
Application number
EA201591915A
Other languages
English (en)
Other versions
EA027306B1 (ru
Inventor
Джереми Шуленбург Йорк
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201591915A1 publication Critical patent/EA201591915A1/ru
Publication of EA027306B1 publication Critical patent/EA027306B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

В настоящем изобретении предложено соединение формулы Iгде R представляет собой Н или F; или его фармацевтически приемлемая соль.
EA201591915A 2013-05-17 2014-05-09 Соединения феноксиэтил дигидро-1h-изохинолина в качестве селективных антагонистов ер4 EA027306B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824436P 2013-05-17 2013-05-17
PCT/US2014/037416 WO2014186218A1 (en) 2013-05-17 2014-05-09 Phenoxyethyl dihydro-1h-isoquinoline compounds

Publications (2)

Publication Number Publication Date
EA201591915A1 true EA201591915A1 (ru) 2016-04-29
EA027306B1 EA027306B1 (ru) 2017-07-31

Family

ID=50877688

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591915A EA027306B1 (ru) 2013-05-17 2014-05-09 Соединения феноксиэтил дигидро-1h-изохинолина в качестве селективных антагонистов ер4

Country Status (17)

Country Link
US (1) US9371289B2 (ru)
EP (1) EP2997015B1 (ru)
JP (1) JP6148400B2 (ru)
KR (1) KR101798315B1 (ru)
CN (1) CN105209438B (ru)
BR (1) BR112015026967B1 (ru)
CA (1) CA2908400C (ru)
EA (1) EA027306B1 (ru)
ES (1) ES2626976T3 (ru)
HU (1) HUE033574T2 (ru)
MX (1) MX2015015841A (ru)
PL (1) PL2997015T3 (ru)
PT (1) PT2997015T (ru)
SA (1) SA515370035B1 (ru)
TW (1) TWI636046B (ru)
WO (1) WO2014186218A1 (ru)
ZA (1) ZA201507566B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014366361B2 (en) * 2013-12-17 2017-04-20 Eli Lilly And Company Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
HRP20211532T1 (hr) 2017-05-18 2022-01-07 Idorsia Pharmaceuticals Ltd N-supstituirani derivati indola
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
CN110612296A (zh) 2017-05-18 2019-12-24 爱杜西亚药品有限公司 作为pge2受体调节剂的苯基衍生物
KR102626982B1 (ko) 2017-05-18 2024-01-18 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 피리미딘 유도체
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500157C2 (de) 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
IT1270615B (it) 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
AU2002359364A1 (en) 2001-11-09 2003-05-26 Enzon, Inc. Polymeric thiol-linked prodrugs employing benzyl elimination systems
US6649606B1 (en) * 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
EP1558253A4 (en) * 2002-10-30 2007-07-25 Merck & Co Inc PIPERIDINYL ALPHA AMINOAMIDE MODULATORS DERCHEMOKIN RECEPTOR ACTIVITY
EP1660439A2 (en) * 2003-08-08 2006-05-31 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
BRPI0414130B8 (pt) 2003-09-03 2021-05-25 Askat Inc compostos de fenilamida ou piridilamida, seu uso e composições farmacêuticas que os compreendem.
KR20070006891A (ko) 2004-05-04 2007-01-11 화이자 인코포레이티드 치환된 메틸 아릴 또는 헤테로아릴 아미드 화합물
ATE435198T1 (de) 2004-05-04 2009-07-15 Raqualia Pharma Inc Orthosubstituierte aryl- oder heteroarylamidverbindungen
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
WO2007121578A1 (en) 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
WO2007143825A1 (en) 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Indoline amide derivatives as ep4 receptor ligands
AU2009247262B2 (en) * 2008-05-14 2013-01-31 Astellas Pharma Inc. Amide compound
CA2733247C (en) 2008-08-14 2018-04-03 Beta Pharma Canada Inc. Heterocyclic amide derivatives as ep4 receptor antagonists
JP6152643B2 (ja) 2010-02-22 2017-06-28 株式会社ＡｓｋＡｔ Ｉｌ−２３媒介疾患を治療するためのｅｐ４受容体拮抗薬の使用
ES2564353T3 (es) 2011-07-04 2016-03-22 Rottapharm Biotech S.R.L. Derivados de aminas cíclicas como agonistas de los receptores EP4
ES2559513T3 (es) * 2011-07-04 2016-02-12 Rottapharm Biotech S.R.L. Derivados de amina cíclica como antagonistas del receptor EP4
EP2572746A1 (en) * 2011-09-23 2013-03-27 Sanofi-Aventis Deutschland GmbH Needle safety device
JO3296B1 (ar) * 2012-06-29 2018-09-16 Lilly Co Eli مركبات فينوكسي إيثيل بيبريدين
TWI572597B (zh) 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基－苯甲酸化合物

Also Published As

Publication number Publication date
ES2626976T3 (es) 2017-07-26
KR101798315B1 (ko) 2017-11-15
EP2997015A1 (en) 2016-03-23
WO2014186218A1 (en) 2014-11-20
EA027306B1 (ru) 2017-07-31
SA515370035B1 (ar) 2018-01-04
PT2997015T (pt) 2017-04-24
AU2014265762A1 (en) 2015-10-15
TWI636046B (zh) 2018-09-21
JP2016519140A (ja) 2016-06-30
JP6148400B2 (ja) 2017-06-14
CN105209438B (zh) 2017-04-12
CN105209438A (zh) 2015-12-30
TW201534588A (zh) 2015-09-16
BR112015026967A2 (pt) 2017-07-25
PL2997015T3 (pl) 2017-09-29
US20160052889A1 (en) 2016-02-25
EP2997015B1 (en) 2017-04-05
US9371289B2 (en) 2016-06-21
HUE033574T2 (hu) 2017-12-28
CA2908400C (en) 2017-04-11
MX2015015841A (es) 2016-03-04
BR112015026967A8 (pt) 2018-01-30
ZA201507566B (en) 2017-06-28
KR20150140831A (ko) 2015-12-16
BR112015026967B1 (pt) 2023-01-10
CA2908400A1 (en) 2014-11-20

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM