IT1270615B - Uso di derivati di chinolina - Google Patents

Uso di derivati di chinolina

Info

Publication number
IT1270615B
IT1270615B ITMI941466A ITMI941466A IT1270615B IT 1270615 B IT1270615 B IT 1270615B IT MI941466 A ITMI941466 A IT MI941466A IT MI941466 A ITMI941466 A IT MI941466A IT 1270615 B IT1270615 B IT 1270615B
Authority
IT
Italy
Prior art keywords
quinoline derivatives
formula
endowed
lung
skin
Prior art date
Application number
ITMI941466A
Other languages
English (en)
Inventor
Carlo Farina
Giuseppe Giardina
Mario Grugni
Luca Raveglia
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Priority to ITMI941466A priority Critical patent/IT1270615B/it
Publication of ITMI941466A0 publication Critical patent/ITMI941466A0/it
Priority to PCT/EP1995/002638 priority patent/WO1996002509A1/en
Publication of ITMI941466A1 publication Critical patent/ITMI941466A1/it
Application granted granted Critical
Publication of IT1270615B publication Critical patent/IT1270615B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

I composti di formula (I) (FORMULA I) dove Ar, R, R1, R2 e R3 hanno i significati dati nella descrizione, sono dotati di attività antagonista del recettore NK3 e pertanto utili nel trattamento di disturbi polmonari, della pelle, dell'infiammazione neurogenica e dei disturbi del SNC.
ITMI941466A 1994-07-14 1994-07-14 Uso di derivati di chinolina IT1270615B (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina
PCT/EP1995/002638 WO1996002509A1 (en) 1994-07-14 1995-07-06 Quinoline derivatives as nk3 antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina

Publications (3)

Publication Number Publication Date
ITMI941466A0 ITMI941466A0 (it) 1994-07-14
ITMI941466A1 ITMI941466A1 (it) 1996-01-14
IT1270615B true IT1270615B (it) 1997-05-07

Family

ID=11369274

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina

Country Status (2)

Country Link
IT (1) IT1270615B (it)
WO (1) WO1996002509A1 (it)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE289994T1 (de) * 1995-11-24 2005-03-15 Glaxosmithkline Spa Chinolin-derivate
GB9524104D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
GB9524137D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
EP0983243B1 (en) * 1997-03-14 2004-06-16 Smithkline Beecham Corporation Novel quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
EP1146873B1 (en) * 1999-01-25 2005-03-16 Smithkline Beecham Corporation Anti-androgens and methods for treating disease
EP1165542B1 (en) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
ES2195943T3 (es) 1999-11-12 2003-12-16 Neurogen Corp Compuestos heteroaromaticos biciclicos y triciclicos.
US6310212B1 (en) 2000-03-28 2001-10-30 Neurogen Corporation 4-substituted quinoline derivatives
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
AU2003269877A1 (en) 2002-05-24 2004-01-06 Amiel G. Jarstfer System and method for inhibiting cellular proliferation with tachykinins
GB0303086D0 (en) 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
US9040558B2 (en) * 2004-12-31 2015-05-26 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
WO2006130080A2 (en) * 2005-06-03 2006-12-07 Astrazeneca Ab Quinoline derivatives as nk3 anatgonists
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
JP2009504642A (ja) * 2005-08-11 2009-02-05 アストラゼネカ・アクチエボラーグ Ｎｋ−３受容体の調節剤としてのオキソピリジルキノリンアミド
WO2007018465A1 (en) * 2005-08-11 2007-02-15 Astrazeneca Ab Amide alkyl pyridiyl quinolines as nk3 receptor modulators
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
JP2009524656A (ja) * 2006-01-27 2009-07-02 アストラゼネカ・アクチエボラーグ アミド置換キノリン
WO2013024358A2 (en) 2011-08-18 2013-02-21 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
MX352074B (es) 2011-09-27 2017-11-08 Dr Reddys Laboratories Ltd Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.
TWI572597B (zh) 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基－苯甲酸化合物
CA2909752A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
DK3083554T3 (da) 2013-12-17 2019-05-13 Lilly Co Eli Dimethylbenzoesyreforbindelser
CN107074773A (zh) 2014-09-09 2017-08-18 拜耳制药股份公司 取代的n,2‑二芳基喹啉‑4‑甲酰胺及其用途
JP2018512404A (ja) 2015-03-18 2018-05-17 バイエル ファーマ アクチエンゲゼルシャフト 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用
WO2017153234A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung
WO2017153231A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung
WO2017153235A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung
AU2018251758B2 (en) * 2017-04-10 2021-11-18 Bayer Aktiengesellschaft Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
TWI770157B (zh) 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
CN110105279B (zh) * 2019-04-15 2022-09-16 中山大学 一种喹啉类stat3特异性抑制剂及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
ITMI941466A0 (it) 1994-07-14
ITMI941466A1 (it) 1996-01-14
WO1996002509A1 (en) 1996-02-01

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