IT1270615B - Uso di derivati di chinolina - Google Patents

Uso di derivati di chinolina

Info

Publication number
IT1270615B
IT1270615B ITMI941466A ITMI941466A IT1270615B IT 1270615 B IT1270615 B IT 1270615B IT MI941466 A ITMI941466 A IT MI941466A IT MI941466 A ITMI941466 A IT MI941466A IT 1270615 B IT1270615 B IT 1270615B
Authority
IT
Italy
Prior art keywords
quinoline derivatives
formula
endowed
lung
skin
Prior art date
Application number
ITMI941466A
Other languages
English (en)
Inventor
Carlo Farina
Giuseppe Giardina
Mario Grugni
Luca Raveglia
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Priority to ITMI941466A priority Critical patent/IT1270615B/it
Publication of ITMI941466A0 publication Critical patent/ITMI941466A0/it
Priority to PCT/EP1995/002638 priority patent/WO1996002509A1/en
Publication of ITMI941466A1 publication Critical patent/ITMI941466A1/it
Application granted granted Critical
Publication of IT1270615B publication Critical patent/IT1270615B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

I composti di formula (I) (FORMULA I) dove Ar, R, R1, R2 e R3 hanno i significati dati nella descrizione, sono dotati di attività antagonista del recettore NK3 e pertanto utili nel trattamento di disturbi polmonari, della pelle, dell'infiammazione neurogenica e dei disturbi del SNC.
ITMI941466A 1994-07-14 1994-07-14 Uso di derivati di chinolina IT1270615B (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina
PCT/EP1995/002638 WO1996002509A1 (en) 1994-07-14 1995-07-06 Quinoline derivatives as nk3 antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina

Publications (3)

Publication Number Publication Date
ITMI941466A0 ITMI941466A0 (it) 1994-07-14
ITMI941466A1 ITMI941466A1 (it) 1996-01-14
IT1270615B true IT1270615B (it) 1997-05-07

Family

ID=11369274

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941466A IT1270615B (it) 1994-07-14 1994-07-14 Uso di derivati di chinolina

Country Status (2)

Country Link
IT (1) IT1270615B (it)
WO (1) WO1996002509A1 (it)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL124522A0 (en) * 1995-11-24 1998-12-06 Smithkline Beecham Spa Quinoline derivatives
GB9524104D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
GB9524137D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
WO1998041506A1 (en) * 1997-03-14 1998-09-24 Smithkline Beecham Corporation Novel quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
JP2002535274A (ja) * 1999-01-25 2002-10-22 スミスクライン・ビーチャム・コーポレイション 抗アンドロゲン剤および疾病の治療方法
JP2002540203A (ja) * 1999-03-29 2002-11-26 ニューロゲン コーポレイション Ｎｋ−３および／またはｇａｂａ（ａ）受容体リガンドとしての４−置換キノリン誘導体
WO2000064877A1 (en) 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
US6511987B1 (en) 1999-11-12 2003-01-28 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
US6310212B1 (en) 2000-03-28 2001-10-30 Neurogen Corporation 4-substituted quinoline derivatives
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
WO2004000208A2 (en) 2002-05-24 2003-12-31 Maier Nathan C System and method for inhibiting cellular proliferation with tachykinins
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
GB0303086D0 (en) 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
KR101238525B1 (ko) * 2004-12-31 2013-02-28 레디 유에스 테라퓨틱스 인코포레이티드 Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체
US20080200500A1 (en) * 2005-06-03 2008-08-21 Astrazeneca Ab Quinoline Derivatives as Nk3 Antagonists
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
EP1915363A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Oxopyridyl quinoline amides as nk3 receptor modulators
JP2009504640A (ja) * 2005-08-11 2009-02-05 アストラゼネカ・アクチエボラーグ Ｎｋ−３受容体の調節剤としてのアミドアルキルピリジルキノリン
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
WO2007086799A1 (en) * 2006-01-27 2007-08-02 Astrazeneca Ab Amide substituted quinolines
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
KR101803866B1 (ko) 2011-09-27 2017-12-04 닥터 레디스 레보러터리즈 리미티드 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체
TWI572597B (zh) 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基－苯甲酸化合物
CA2909752A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
CA2929562A1 (en) 2013-12-17 2015-06-25 Eli Lilly And Company Dimethylbenzoic acid compounds
WO2016037954A1 (de) 2014-09-09 2016-03-17 Bayer Pharma Aktiengesellschaft Substituierte n,2-diarylchinolin-4-carboxamide und ihre anti-inflammatorische verwendung
JP2018512404A (ja) 2015-03-18 2018-05-17 バイエル ファーマ アクチエンゲゼルシャフト 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用
WO2017153235A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung
WO2017153231A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung
WO2017153234A1 (de) 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung
CA3059273A1 (en) * 2017-04-10 2018-10-18 Bayer Aktiengesellschaft Substituted n-arylethyl-2-arylquinoline-4-carboxamides and use thereof
TWI770157B (zh) 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
CN110105279B (zh) * 2019-04-15 2022-09-16 中山大学 一种喹啉类stat3特异性抑制剂及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
WO1996002509A1 (en) 1996-02-01
ITMI941466A0 (it) 1994-07-14
ITMI941466A1 (it) 1996-01-14

Similar Documents

Publication Publication Date Title
IT1270615B (it) Uso di derivati di chinolina
TR200101859T2 (tr) Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
FI931250A (fi) Sulfonamido- och sulfonamidokarbonyl-pyridin-2-karboxylsyraamider och deras pyridin-n-oxider, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
DE69027057D1 (de) Retinal, dessen Derivate und deren therapeutische Verwendung
ATE177099T1 (de) Diazabicyclische neurokinin antagonisten
NO954453D0 (no) Nye pyridin-, pyrimidin- og benzenderivater som adreno-ceptorantagonister
ATE302606T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
IT1285770B1 (it) Composti corticoidei
DE69523155D1 (de) Benzimidazolonderivate mit zentraler dopaminerger aktivität
FI970469A (fi) Bentsimidatsolijohdannaisia, joilla on dopaminerginen aktiivisuus
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
AU5614198A (en) Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
DE69623819T2 (de) Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten
NO953892L (no) Imidazolokinoksalinon-derivater som EAA-antagonister
NO991734L (no) Pyrazolinoner for behandling av potensforstyrrelser
ATE28188T1 (de) Antikonvulsive mittel.
DE3879985D1 (de) Anticonvulsive agenzien.
ATE57526T1 (de) P-acylaminobenzamide.
AR021502A1 (es) Uso de derivados de azabicicloalcanos n-sustituidos para el tratamiento de enfermedades del sistema central nervioso
SU1417444A1 (ru) 2,4-Дифенил-3(4-ацетокси-4-метилгексин-2-ил)-3-азабицикло [3,3,1]нонан-9-он, проявляющий противовоспалительную активность
SU1549026A1 (ru) 4-Карбэтокси-4-(2-п-толиламинотиазолил-4)-гексановая кислота, проявляющая противовоспалительную активность
UA11675A1 (uk) 1-БЕtА-ОКСИЕТИЛАМІHО-3-КЕТО-5,5-ДИМЕТИЛЦИКЛОГЕКСЕH -1, ЯКИЙ МАЄ АHАЛЬГЕТИЧHУ АКТИВHІСТЬ

Legal Events

Date Code Title Description
0001 Granted