SI3083554T1 - Spojine dimetilbenzojske kisline - Google Patents
Spojine dimetilbenzojske kislineInfo
- Publication number
- SI3083554T1 SI3083554T1 SI201431139T SI201431139T SI3083554T1 SI 3083554 T1 SI3083554 T1 SI 3083554T1 SI 201431139 T SI201431139 T SI 201431139T SI 201431139 T SI201431139 T SI 201431139T SI 3083554 T1 SI3083554 T1 SI 3083554T1
- Authority
- SI
- Slovenia
- Prior art keywords
- acid compounds
- dimethylbenzoic acid
- dimethylbenzoic
- compounds
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361916824P | 2013-12-17 | 2013-12-17 | |
| EP14827908.6A EP3083554B1 (en) | 2013-12-17 | 2014-12-11 | Dimethylbenzoic acid compounds |
| PCT/US2014/069783 WO2015094912A1 (en) | 2013-12-17 | 2014-12-11 | Dimethylbenzoic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3083554T1 true SI3083554T1 (sl) | 2019-04-30 |
Family
ID=52355186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431139T SI3083554T1 (sl) | 2013-12-17 | 2014-12-11 | Spojine dimetilbenzojske kisline |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10005721B2 (sl) |
| EP (1) | EP3083554B1 (sl) |
| JP (1) | JP6200596B2 (sl) |
| KR (1) | KR101937186B1 (sl) |
| CN (1) | CN105793236B (sl) |
| AU (1) | AU2014366371B2 (sl) |
| CA (1) | CA2929562A1 (sl) |
| CY (1) | CY1121677T1 (sl) |
| DK (1) | DK3083554T3 (sl) |
| EA (1) | EA028675B1 (sl) |
| ES (1) | ES2727329T3 (sl) |
| HR (1) | HRP20190793T1 (sl) |
| HU (1) | HUE043614T2 (sl) |
| LT (1) | LT3083554T (sl) |
| ME (1) | ME03398B (sl) |
| MX (1) | MX368178B (sl) |
| PL (1) | PL3083554T3 (sl) |
| PT (1) | PT3083554T (sl) |
| RS (1) | RS58594B1 (sl) |
| SA (1) | SA516371324B1 (sl) |
| SI (1) | SI3083554T1 (sl) |
| TR (1) | TR201904327T4 (sl) |
| WO (1) | WO2015094912A1 (sl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10189788B2 (en) | 2014-09-09 | 2019-01-29 | Bayer Pharma Aktiengesellschaft | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents |
| US10745382B2 (en) * | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| WO2017153235A1 (de) * | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| EA201992386A1 (ru) | 2017-04-10 | 2020-03-27 | Байер Акциенгезельшафт | Замещенные n-арилэтил-2-арилхинолин-4-карбоксамиды и их применение |
| TWI770157B (zh) | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
| US11446298B2 (en) | 2017-05-18 | 2022-09-20 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| AU2018268311B2 (en) | 2017-05-18 | 2022-02-10 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as PGE2 receptor modulators |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| AR111941A1 (es) | 2017-05-18 | 2019-09-04 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| BR112019024114A2 (pt) | 2017-05-18 | 2020-06-02 | Idorsia Pharmaceuticals Ltd | Composto, e, métodos de modulação de uma resposta imune e de profilaxia ou tratamento de uma condição |
| CA3126484A1 (en) * | 2019-01-22 | 2020-07-30 | Keythera (Suzhou) Pharmaceuticals Co. Ltd. | Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof |
| KR20230107228A (ko) | 2020-11-13 | 2023-07-14 | 오노 야꾸힝 고교 가부시키가이샤 | Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| TW502026B (en) * | 1995-06-20 | 2002-09-11 | Zeneca Ltd | Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates |
| CA2361819A1 (en) * | 1999-03-17 | 2000-09-21 | Astrazeneca Ab | Amide derivatives |
| ES2441206T3 (es) * | 2003-09-03 | 2014-02-03 | Raqualia Pharma Inc. | Compuestos de fenil o piridilamida como antagonistas de la prostaglandina E2 |
| SI1664016T1 (sl) | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Terapevtska sredstva, uporabna za zdravljenje bolečine |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2005080367A1 (en) * | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
| EA200601830A1 (ru) * | 2004-05-04 | 2007-04-27 | Пфайзер Инк. | Ортозамещённые арильные или гетероарильные амидные соединения |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| EP2035376B1 (en) * | 2006-06-12 | 2014-08-27 | Merck Canada Inc. | Indoline amide derivatives as ep4 receptor ligands |
| EP2460787A1 (en) * | 2007-07-03 | 2012-06-06 | Astellas Pharma Inc. | Amide compounds and their use as PGE2 antagonists. |
| WO2010043592A1 (en) | 2008-10-15 | 2010-04-22 | Revotar Biopharmaceuticals Ag | Lipase inhibitors for use for the treatment of obesity |
| BRPI1007302A2 (pt) * | 2009-01-30 | 2019-09-24 | Toyama Chemical Co Ltd | composto, inibidor da produção de colágeno, e, agente para tratar doenças associadas com a produção excessiva de colágeno |
| DK2607348T3 (da) * | 2009-03-31 | 2021-05-25 | Renascience Inc | Inhibitor af plasminogenaktivatorinhibitor-1 |
| WO2012004293A2 (de) | 2010-07-08 | 2012-01-12 | Bayer Cropscience Ag | Insektizide und fungizide wirkstoffkombinationen |
| WO2012117097A1 (en) | 2011-03-03 | 2012-09-07 | Universität des Saarlandes | Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors |
| CN103874682A (zh) * | 2011-08-31 | 2014-06-18 | 阿玛克姆股份有限公司 | 作为rock激酶抑制剂的联苯基羧酰胺 |
| KR20140097127A (ko) * | 2011-09-16 | 2014-08-06 | 포비어 파마수티칼스 | 아닐린 유도체, 그의 제조법 및 그의 치료 용도 |
| TWI572597B (zh) * | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | 二甲基－苯甲酸化合物 |
| EP2765128A1 (en) * | 2013-02-07 | 2014-08-13 | Almirall, S.A. | Substituted benzamides with activity towards EP4 receptors |
-
2014
- 2014-12-11 WO PCT/US2014/069783 patent/WO2015094912A1/en active Application Filing
- 2014-12-11 DK DK14827908.6T patent/DK3083554T3/da active
- 2014-12-11 CA CA2929562A patent/CA2929562A1/en not_active Abandoned
- 2014-12-11 KR KR1020167015772A patent/KR101937186B1/ko active IP Right Grant
- 2014-12-11 PL PL14827908T patent/PL3083554T3/pl unknown
- 2014-12-11 EA EA201690911A patent/EA028675B1/ru not_active IP Right Cessation
- 2014-12-11 RS RS20190469A patent/RS58594B1/sr unknown
- 2014-12-11 ES ES14827908T patent/ES2727329T3/es active Active
- 2014-12-11 ME MEP-2019-106A patent/ME03398B/me unknown
- 2014-12-11 AU AU2014366371A patent/AU2014366371B2/en not_active Ceased
- 2014-12-11 HU HUE14827908A patent/HUE043614T2/hu unknown
- 2014-12-11 CN CN201480066576.6A patent/CN105793236B/zh not_active Expired - Fee Related
- 2014-12-11 EP EP14827908.6A patent/EP3083554B1/en active Active
- 2014-12-11 LT LTEP14827908.6T patent/LT3083554T/lt unknown
- 2014-12-11 SI SI201431139T patent/SI3083554T1/sl unknown
- 2014-12-11 MX MX2016007861A patent/MX368178B/es active IP Right Grant
- 2014-12-11 US US15/030,891 patent/US10005721B2/en not_active Expired - Fee Related
- 2014-12-11 JP JP2016538636A patent/JP6200596B2/ja not_active Expired - Fee Related
- 2014-12-11 TR TR2019/04327T patent/TR201904327T4/tr unknown
- 2014-12-11 PT PT14827908T patent/PT3083554T/pt unknown
-
2016
- 2016-06-14 SA SA516371324A patent/SA516371324B1/ar unknown
-
2019
- 2019-04-29 HR HRP20190793TT patent/HRP20190793T1/hr unknown
- 2019-05-08 CY CY20191100495T patent/CY1121677T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10005721B2 (en) | 2018-06-26 |
| ES2727329T3 (es) | 2019-10-15 |
| US20160251306A1 (en) | 2016-09-01 |
| JP6200596B2 (ja) | 2017-09-20 |
| EA028675B1 (ru) | 2017-12-29 |
| CA2929562A1 (en) | 2015-06-25 |
| HUE043614T2 (hu) | 2019-08-28 |
| MX368178B (es) | 2019-09-23 |
| KR20160086905A (ko) | 2016-07-20 |
| RS58594B1 (sr) | 2019-05-31 |
| MX2016007861A (es) | 2017-01-11 |
| AU2014366371A1 (en) | 2016-05-19 |
| PT3083554T (pt) | 2019-06-11 |
| ME03398B (me) | 2020-01-20 |
| CY1121677T1 (el) | 2020-07-31 |
| WO2015094912A1 (en) | 2015-06-25 |
| CN105793236B (zh) | 2017-10-10 |
| EA201690911A1 (ru) | 2016-09-30 |
| AU2014366371B2 (en) | 2017-02-16 |
| CN105793236A (zh) | 2016-07-20 |
| DK3083554T3 (da) | 2019-05-13 |
| HRP20190793T1 (hr) | 2019-06-28 |
| JP2017500309A (ja) | 2017-01-05 |
| EP3083554B1 (en) | 2019-03-13 |
| TR201904327T4 (tr) | 2019-04-22 |
| SA516371324B1 (ar) | 2018-03-22 |
| PL3083554T3 (pl) | 2019-08-30 |
| LT3083554T (lt) | 2019-05-10 |
| EP3083554A1 (en) | 2016-10-26 |
| KR101937186B1 (ko) | 2019-01-10 |
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