PE20171341A1 - Compuestos de pirazina para el tratamiento de enfermedades infecciosas - Google Patents

Compuestos de pirazina para el tratamiento de enfermedades infecciosas

Info

Publication number
PE20171341A1
PE20171341A1 PE2017001212A PE2017001212A PE20171341A1 PE 20171341 A1 PE20171341 A1 PE 20171341A1 PE 2017001212 A PE2017001212 A PE 2017001212A PE 2017001212 A PE2017001212 A PE 2017001212A PE 20171341 A1 PE20171341 A1 PE 20171341A1
Authority
PE
Peru
Prior art keywords
compounds
phenyl
treatment
pyrazine
heteroaryl
Prior art date
Application number
PE2017001212A
Other languages
English (en)
Inventor
taishan Hu
Xingchun Han
Buyu Kou
Hong Shen
Shixiang Yan
Zhisen Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20171341A1 publication Critical patent/PE20171341A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Se refiere a compuestos de formula I, donde: R1 es heterociclilo, heteroarilo o fenilo, donde cada anillo se encuentran opcionalmente sustituidos; R2 y R3 son hidrogeno o alquilo C1-C6; R4 es heteroarilo, arilo, fenil-alquilo C1-C6 o cicloalquilo C3-C7, donde cada heteroarilo, arilo o fenil-alquilo C1-C6 se encuentran opcionalmente sustituidos; Y y Q son CH o N. Son compuestos preferidos: N-(3-ciano-4-fluoro-fenil)-3-(2,4-difluorofenil)-6-metil-6,7-dihidro-4H-pirazolo[1,5-a]pirazin-5-carboxamida; N-(3-cloro-4-fluoro-fenil)-3-(2,4-difluorofenil)-6-metil-6,7-dihidro-4H-pirazolo[1,5-a]pirazin-5-carboxamida; entre otros. Tambien se refiere a un procedimiento de obtencion y una composicion farmaceutica. Dichos compuestos son derivados de pirazina utiles en el tratamiento de infecciones causadas por el virus de la hepatitis B
PE2017001212A 2015-01-16 2016-01-13 Compuestos de pirazina para el tratamiento de enfermedades infecciosas PE20171341A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015070896 2015-01-16
CN2015077356 2015-04-24
CN2015097403 2015-12-15

Publications (1)

Publication Number Publication Date
PE20171341A1 true PE20171341A1 (es) 2017-09-13

Family

ID=55135220

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017001212A PE20171341A1 (es) 2015-01-16 2016-01-13 Compuestos de pirazina para el tratamiento de enfermedades infecciosas

Country Status (32)

Country Link
US (2) US9890167B2 (es)
EP (1) EP3245206B1 (es)
JP (1) JP6445708B2 (es)
KR (1) KR102073197B1 (es)
CN (1) CN107207515B (es)
AU (1) AU2016208095B2 (es)
BR (1) BR112017015242A2 (es)
CA (1) CA2973760A1 (es)
CL (1) CL2017001798A1 (es)
CO (1) CO2017007355A2 (es)
CR (1) CR20170316A (es)
DK (1) DK3245206T3 (es)
EA (1) EA032260B1 (es)
ES (1) ES2722548T3 (es)
HK (1) HK1244280B (es)
HR (1) HRP20190763T1 (es)
HU (1) HUE044188T2 (es)
IL (1) IL253062B (es)
LT (1) LT3245206T (es)
MA (1) MA41338B1 (es)
MX (1) MX2017009244A (es)
MY (1) MY192300A (es)
PE (1) PE20171341A1 (es)
PH (1) PH12017501258A1 (es)
PL (1) PL3245206T3 (es)
PT (1) PT3245206T (es)
RS (1) RS58680B1 (es)
SG (1) SG11201705796YA (es)
SI (1) SI3245206T1 (es)
TW (1) TWI583686B (es)
UA (1) UA122219C2 (es)
WO (1) WO2016113273A1 (es)

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