EA202091114A1 - Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv) - Google Patents

Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv)

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Publication number
EA202091114A1
EA202091114A1 EA202091114A EA202091114A EA202091114A1 EA 202091114 A1 EA202091114 A1 EA 202091114A1 EA 202091114 A EA202091114 A EA 202091114A EA 202091114 A EA202091114 A EA 202091114A EA 202091114 A1 EA202091114 A1 EA 202091114A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hbv
virus
pyrazolopiperidine
carboxamides
active
Prior art date
Application number
EA202091114A
Other languages
English (en)
Inventor
Аластэр Дональд
Андреас Урбан
Зузанне Бонсманн
Анита Вегерт
Яспер Спрингер
Original Assignee
Айкурис Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айкурис Гмбх Унд Ко. Кг filed Critical Айкурис Гмбх Унд Ко. Кг
Publication of EA202091114A1 publication Critical patent/EA202091114A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Настоящее изобретение относится главным образом к новым противовирусным средствам. В частности, настоящее изобретение относится к соединениям, которые могут ингибировать белок (белки), кодируемый вирусом гепатита B (HBV), или препятствовать функционированию цикла репликации HBV, композициям, включающим такие соединения, способам ингибирования репликации вируса HBV, способам лечения или профилактики HBV инфекции и способам и промежуточным соединениям для получения соединений.
EA202091114A 2017-11-02 2018-11-02 Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv) EA202091114A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17199676 2017-11-02
PCT/EP2018/000503 WO2019086142A1 (en) 2017-11-02 2018-11-02 Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)

Publications (1)

Publication Number Publication Date
EA202091114A1 true EA202091114A1 (ru) 2020-07-24

Family

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Family Applications (1)

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EA202091114A EA202091114A1 (ru) 2017-11-02 2018-11-02 Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv)

Country Status (22)

Country Link
US (1) US11236087B2 (ru)
EP (1) EP3704119A1 (ru)
JP (1) JP2021501768A (ru)
KR (1) KR20200083552A (ru)
CN (1) CN111527087A (ru)
AR (1) AR115131A1 (ru)
AU (1) AU2018361365C1 (ru)
BR (1) BR112020008765A2 (ru)
CA (1) CA3081399A1 (ru)
CL (1) CL2020001146A1 (ru)
CU (1) CU20200045A7 (ru)
EA (1) EA202091114A1 (ru)
EC (1) ECSP20029569A (ru)
GE (1) GEP20227374B (ru)
IL (1) IL274297A (ru)
MA (1) MA50520A (ru)
MX (1) MX2020004838A (ru)
PH (1) PH12020550531A1 (ru)
SG (1) SG11202003746UA (ru)
TW (1) TW201925199A (ru)
UY (1) UY37961A (ru)
WO (1) WO2019086142A1 (ru)

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Publication number Publication date
CU20200045A7 (es) 2021-03-11
SG11202003746UA (en) 2020-05-28
TW201925199A (zh) 2019-07-01
CN111527087A (zh) 2020-08-11
JP2021501768A (ja) 2021-01-21
WO2019086142A1 (en) 2019-05-09
AU2018361365B2 (en) 2021-04-01
EP3704119A1 (en) 2020-09-09
IL274297A (en) 2020-06-30
US11236087B2 (en) 2022-02-01
MA50520A (fr) 2020-09-09
UY37961A (es) 2019-05-31
AR115131A1 (es) 2020-12-02
KR20200083552A (ko) 2020-07-08
MX2020004838A (es) 2020-10-16
ECSP20029569A (es) 2020-07-31
CL2020001146A1 (es) 2020-10-09
US20210179608A1 (en) 2021-06-17
GEP20227374B (en) 2022-04-25
CA3081399A1 (en) 2019-05-09
BR112020008765A2 (pt) 2020-10-20
AU2018361365C1 (en) 2021-08-05
AU2018361365A1 (en) 2020-05-21
PH12020550531A1 (en) 2021-03-22

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