ECSP21031082A - Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) - Google Patents

Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)

Info

Publication number
ECSP21031082A
ECSP21031082A ECSENADI202131082A ECDI202131082A ECSP21031082A EC SP21031082 A ECSP21031082 A EC SP21031082A EC SENADI202131082 A ECSENADI202131082 A EC SENADI202131082A EC DI202131082 A ECDI202131082 A EC DI202131082A EC SP21031082 A ECSP21031082 A EC SP21031082A
Authority
EC
Ecuador
Prior art keywords
hbv
virus
pirazolo
dihidro
pyrazines
Prior art date
Application number
ECSENADI202131082A
Other languages
English (en)
Inventor
Susanne Bonsmann
Andreas Urban
Alastair Donald
Original Assignee
Aicuris Gmbh Co Kg [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh Co Kg [De/De] filed Critical Aicuris Gmbh Co Kg [De/De]
Publication of ECSP21031082A publication Critical patent/ECSP21031082A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden dichos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
ECSENADI202131082A 2018-11-02 2021-04-29 Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) ECSP21031082A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000877 2018-11-02

Publications (1)

Publication Number Publication Date
ECSP21031082A true ECSP21031082A (es) 2021-05-31

Family

ID=64362287

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202131082A ECSP21031082A (es) 2018-11-02 2021-04-29 Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)

Country Status (19)

Country Link
US (1) US20210355129A1 (es)
EP (1) EP3873908A1 (es)
JP (1) JP2022512870A (es)
KR (1) KR20210098986A (es)
CN (1) CN113039186A (es)
AR (1) AR117188A1 (es)
AU (1) AU2019370735A1 (es)
BR (1) BR112021008360A2 (es)
CA (1) CA3118387A1 (es)
CL (1) CL2021001116A1 (es)
CU (1) CU20210037A7 (es)
EA (1) EA202191219A1 (es)
EC (1) ECSP21031082A (es)
IL (1) IL282587A (es)
MX (1) MX2021004987A (es)
SG (1) SG11202104126UA (es)
TW (1) TW202031662A (es)
UY (1) UY38437A (es)
WO (1) WO2020089459A1 (es)

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CA3100731A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
TWI829716B (zh) 2018-07-05 2024-01-21 美商英塞特公司 作為a2a/a2b 抑制劑之稠合吡嗪衍生物
UY38436A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
AR117189A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CA3138384A1 (en) * 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)

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Also Published As

Publication number Publication date
UY38437A (es) 2020-05-29
EP3873908A1 (en) 2021-09-08
BR112021008360A2 (pt) 2021-08-03
CN113039186A (zh) 2021-06-25
JP2022512870A (ja) 2022-02-07
CU20210037A7 (es) 2021-12-08
TW202031662A (zh) 2020-09-01
KR20210098986A (ko) 2021-08-11
EA202191219A1 (ru) 2021-07-28
US20210355129A1 (en) 2021-11-18
AR117188A1 (es) 2021-07-21
CA3118387A1 (en) 2020-05-07
CL2021001116A1 (es) 2021-11-05
IL282587A (en) 2021-06-30
MX2021004987A (es) 2021-06-15
WO2020089459A1 (en) 2020-05-07
SG11202104126UA (en) 2021-05-28
AU2019370735A1 (en) 2021-05-27

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