ECSP21080338A - Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) - Google Patents
Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)Info
- Publication number
- ECSP21080338A ECSP21080338A ECSENADI202180338A ECDI202180338A ECSP21080338A EC SP21080338 A ECSP21080338 A EC SP21080338A EC SENADI202180338 A ECSENADI202180338 A EC SENADI202180338A EC DI202180338 A ECDI202180338 A EC DI202180338A EC SP21080338 A ECSP21080338 A EC SP21080338A
- Authority
- EC
- Ecuador
- Prior art keywords
- hbv
- virus
- new
- oxalil
- piperazines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19172008 | 2019-04-30 | ||
EP19172402 | 2019-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP21080338A true ECSP21080338A (es) | 2021-12-30 |
Family
ID=70456795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202180338A ECSP21080338A (es) | 2019-04-30 | 2021-11-12 | Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220227737A1 (es) |
EP (1) | EP3962909B1 (es) |
JP (1) | JP2022533008A (es) |
KR (1) | KR20220003023A (es) |
CN (1) | CN113748111A (es) |
AU (1) | AU2020266258A1 (es) |
BR (1) | BR112021021652A2 (es) |
CA (1) | CA3138380A1 (es) |
CL (1) | CL2021002798A1 (es) |
CU (1) | CU20210090A7 (es) |
EC (1) | ECSP21080338A (es) |
IL (1) | IL287269A (es) |
MX (1) | MX2021013105A (es) |
SG (1) | SG11202111493WA (es) |
TW (1) | TWI753418B (es) |
UY (1) | UY38684A (es) |
WO (1) | WO2020221811A1 (es) |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
WO2000058302A1 (de) | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b |
DE60033657T2 (de) | 1999-04-23 | 2007-11-08 | Extenday IP Ltd., Kumeu | Foliebefestigungs- und verankerungsteil |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
PE20091158A1 (es) * | 2007-12-19 | 2009-08-28 | Genentech Inc | 5-anilinoimidazopiridinas y metodos de uso |
EP2726459B1 (en) | 2011-07-01 | 2019-09-11 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
ES2649410T3 (es) | 2011-12-21 | 2018-01-11 | Novira Therapeutics Inc. | Agentes antivirales para la hepatitis B |
JP6162144B2 (ja) | 2012-01-06 | 2017-07-19 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 4,4−二置換−1,4−ジヒドロピリミジン、及びb型肝炎の処置のための医薬としてのその使用 |
BR112015004161B8 (pt) | 2012-08-28 | 2022-11-08 | Janssen Sciences Ireland Uc | Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende |
TW201920090A (zh) | 2012-08-28 | 2019-06-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基-芳醯胺類及其做為治療b型肝炎之醫藥劑的用途 |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
RS57999B1 (sr) | 2013-05-17 | 2019-01-31 | Janssen Sciences Ireland Uc | Derivati sulfamoiltiofenamida i njihova primena kao lekovi za tretman hepatitisa b |
EA201592126A1 (ru) | 2013-05-17 | 2016-05-31 | Ф. Хоффманн-Ля Рош Аг | 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b |
AU2014294997B2 (en) | 2013-07-25 | 2018-03-22 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
CA2927560A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
KR20160127714A (ko) | 2013-11-14 | 2016-11-04 | 노비라 테라퓨틱스, 인코포레이티드 | 아제판 유도체 및 b형 간염 감염의 치료 방법 |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
LT3114128T (lt) | 2014-03-07 | 2019-03-25 | F. Hoffmann-La Roche Ag | Nauji 6 padėtyje kondensuoti heteroarildihidropirimidinai, skirti hepatito b virusinės infekcijos gydymui ir profilaktikai |
HUE046567T2 (hu) | 2014-03-13 | 2020-03-30 | Univ Indiana Res & Tech Corp | Hepatitis B mag protein allosztérikus modulátorok |
EP3122747B1 (en) | 2014-03-28 | 2020-05-20 | North & South Brother Pharmacy Investment Company Limited | Dihydropyrimidine compounds and their application in pharmaceuticals |
US20170266197A1 (en) | 2014-05-09 | 2017-09-21 | Indiana University Research And Technology Corporation | Methods and compositions for treating hepatitis b virus infections |
BR112017002970B1 (pt) | 2014-08-14 | 2023-04-11 | F. Hoffmann-La Roche Ag | Novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b |
JP2018504373A (ja) | 2014-12-02 | 2018-02-15 | ノヴィラ・セラピューティクス・インコーポレイテッド | Hbv治療用のスルフィドアルキル及びピリジルリバーススルホンアミド化合物 |
CA2972434A1 (en) | 2014-12-30 | 2016-07-07 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis b infections |
MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
CN107427514B (zh) | 2015-03-16 | 2021-07-13 | 豪夫迈·罗氏有限公司 | 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗 |
WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
WO2016168619A1 (en) | 2015-04-17 | 2016-10-20 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
JP6462155B2 (ja) | 2015-05-04 | 2019-01-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染症の治療用のHBsAg(HBV表面抗原)及びHBV DNA産生の阻害剤としてのテトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類 |
WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
WO2017013046A1 (en) | 2015-07-21 | 2017-01-26 | F. Hoffmann-La Roche Ag | Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
WO2017015451A1 (en) | 2015-07-22 | 2017-01-26 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
TWI721016B (zh) | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
JP6845231B2 (ja) | 2015-09-29 | 2021-03-17 | ノヴィラ・セラピューティクス・インコーポレイテッド | B型肝炎抗ウイルス薬の結晶形態 |
EP3372606B1 (en) | 2015-11-04 | 2020-04-08 | Qilu Pharmaceutical Co., Ltd | Crystal form, preparation method and intermediate of dihydropyrido ring compound |
WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
CN109311865B (zh) | 2016-04-06 | 2021-08-31 | 上海挚盟医药科技有限公司 | 抗乙肝病毒的吡唑-噁唑烷酮类化合物 |
EP3458455B1 (en) | 2016-05-20 | 2021-06-16 | F. Hoffmann-La Roche AG | Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases |
WO2018011162A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | Carboxy 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
WO2018011160A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
JP7051804B2 (ja) * | 2016-07-14 | 2022-04-11 | エフ.ホフマン-ラ ロシュ アーゲー | 感染症の治療のための6,7-ジヒドロ-4H-ピラゾロ[1,5-a]ピラジン化合物と6,7-ジヒドロ-4H-トリアゾロ[1,5-a]ピラジン化合物 |
JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
CA3036245C (en) | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
BR112019018230A2 (pt) | 2017-03-02 | 2020-07-21 | Assembly Biosciences, Inc. | compostos de sulfamida cíclica e métodos de sua utilização |
MA49014A (fr) | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
JP7123429B2 (ja) | 2017-05-04 | 2022-08-23 | シャンハイ ロングウッド バイオファルマシューティカルズ カンパニー リミテッド | 二環式縮合環系ヌクレオカプシド阻害剤および薬物としてb型肝炎を治療するためのその使用 |
JP2020528062A (ja) | 2017-07-27 | 2020-09-17 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ピペラジンヘテロアリール誘導体、その製造方法、およびその医薬での使用 |
TW201912153A (zh) | 2017-08-30 | 2019-04-01 | 加拿大商愛彼特生物製藥公司 | 用於治療b型肝炎的化合物、醫藥組合物及方法 |
US10759774B2 (en) | 2017-09-28 | 2020-09-01 | The Curators Of The University Of Missouri | Inhibitors of hepatitis B virus targeting capsid assembly |
-
2020
- 2020-04-29 JP JP2021564290A patent/JP2022533008A/ja active Pending
- 2020-04-29 MX MX2021013105A patent/MX2021013105A/es unknown
- 2020-04-29 CN CN202080032036.1A patent/CN113748111A/zh active Pending
- 2020-04-29 BR BR112021021652A patent/BR112021021652A2/pt unknown
- 2020-04-29 CU CU2021000090A patent/CU20210090A7/es unknown
- 2020-04-29 WO PCT/EP2020/061920 patent/WO2020221811A1/en unknown
- 2020-04-29 AU AU2020266258A patent/AU2020266258A1/en not_active Abandoned
- 2020-04-29 US US17/607,430 patent/US20220227737A1/en active Pending
- 2020-04-29 CA CA3138380A patent/CA3138380A1/en active Pending
- 2020-04-29 EP EP20721247.3A patent/EP3962909B1/en active Active
- 2020-04-29 KR KR1020217038550A patent/KR20220003023A/ko unknown
- 2020-04-29 SG SG11202111493WA patent/SG11202111493WA/en unknown
- 2020-04-30 TW TW109114651A patent/TWI753418B/zh active
- 2020-05-04 UY UY0001038684A patent/UY38684A/es unknown
-
2021
- 2021-10-14 IL IL287269A patent/IL287269A/en unknown
- 2021-10-25 CL CL2021002798A patent/CL2021002798A1/es unknown
- 2021-11-12 EC ECSENADI202180338A patent/ECSP21080338A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2021002798A1 (es) | 2022-06-10 |
MX2021013105A (es) | 2021-11-17 |
BR112021021652A2 (pt) | 2021-12-21 |
UY38684A (es) | 2020-11-30 |
IL287269A (en) | 2021-12-01 |
AU2020266258A1 (en) | 2021-12-23 |
TWI753418B (zh) | 2022-01-21 |
JP2022533008A (ja) | 2022-07-21 |
CN113748111A (zh) | 2021-12-03 |
US20220227737A1 (en) | 2022-07-21 |
WO2020221811A1 (en) | 2020-11-05 |
EP3962909A1 (en) | 2022-03-09 |
EP3962909B1 (en) | 2023-10-04 |
TW202106678A (zh) | 2021-02-16 |
CU20210090A7 (es) | 2022-06-06 |
KR20220003023A (ko) | 2022-01-07 |
SG11202111493WA (en) | 2021-11-29 |
AU2020266258A2 (en) | 2022-05-05 |
CA3138380A1 (en) | 2020-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020004838A (es) | Nuevas indol-2-carboxamidas sustituidas con pirazolopiperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb). | |
ECSP20029558A (es) | Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb) | |
UY38434A (es) | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv) | |
CL2021001116A1 (es) | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) | |
CL2021001117A1 (es) | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) | |
CL2020000487A1 (es) | Agentes antivirales contra la hepatitis b. | |
CO2019000069A2 (es) | Agentes antivirales contra la hepatitis b | |
ECSP21078893A (es) | Nuevas fenil y piridil ureas activas contra el virus de la hepatitis b (vhb) | |
UY38435A (es) | Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb) | |
UY38439A (es) | Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) | |
ECSP21080338A (es) | Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) | |
ECSP21079317A (es) | Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) | |
UY38681A (es) | Nuevas indolizina-2-carboxamidas activas contra el virus de la hepatitis b (vhb) | |
EA202192969A1 (ru) | Новые оксалилпиперазины, активные против вируса гепатита b (вгв) | |
EA202192967A1 (ru) | Новые индол-2-карбоксамиды, активные против вируса гепатита b (вгв) | |
EA202192965A1 (ru) | Новые индолизин-2-карбоксамиды, активные против вируса гепатита b (вгв) | |
BR112022020820A2 (pt) | Análogos de nucleosídeos alquinílicos para o tratamento de hepatite e |