CO2019000069A2 - Agentes antivirales contra la hepatitis b - Google Patents

Agentes antivirales contra la hepatitis b

Info

Publication number
CO2019000069A2
CO2019000069A2 CONC2019/0000069A CO2019000069A CO2019000069A2 CO 2019000069 A2 CO2019000069 A2 CO 2019000069A2 CO 2019000069 A CO2019000069 A CO 2019000069A CO 2019000069 A2 CO2019000069 A2 CO 2019000069A2
Authority
CO
Colombia
Prior art keywords
antiviral agents
present
hepatitis
compounds
agents against
Prior art date
Application number
CONC2019/0000069A
Other languages
English (en)
Inventor
Yao-Ling Qiu
Xuri Gao
Wei Li
Hui Cao
Meizhong Jin
Jorden Kass
Xiaowen Peng
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CO2019000069A2 publication Critical patent/CO2019000069A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

La presente invención describe compuestos de Fórmula (I), o sales aceptables farmacéuticamente de estos: que inhiben la(s) proteína(s) codificada(s) por el virus de la hepatitis B (VHB) o interfieren con la función del ciclo de vida del virus de la hepatitis B y son útiles además como agentes antivirales. La presente invención se relaciona además con las composiciones farmacéuticas que comprenden los compuestos antes mencionados para la administración a un sujeto que padece de infección por el VHB. La invención se refiere, además, a métodos para tratar una infección por VHB en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.
CONC2019/0000069A 2016-06-10 2019-01-04 Agentes antivirales contra la hepatitis b CO2019000069A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662348419P 2016-06-10 2016-06-10
US201762443245P 2017-01-06 2017-01-06
PCT/US2017/036553 WO2017214395A1 (en) 2016-06-10 2017-06-08 Hepatitis b antiviral agents

Publications (1)

Publication Number Publication Date
CO2019000069A2 true CO2019000069A2 (es) 2019-02-08

Family

ID=60573663

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0000069A CO2019000069A2 (es) 2016-06-10 2019-01-04 Agentes antivirales contra la hepatitis b

Country Status (15)

Country Link
US (3) US10189846B2 (es)
EP (1) EP3468561A4 (es)
JP (1) JP2019521972A (es)
KR (1) KR20190027814A (es)
CN (1) CN109843296A (es)
AU (1) AU2017277664A1 (es)
BR (1) BR112018075465A2 (es)
CA (1) CA3028228A1 (es)
CL (1) CL2018003492A1 (es)
CO (1) CO2019000069A2 (es)
IL (1) IL263535A (es)
MX (1) MX2018015315A (es)
PH (1) PH12018550201A1 (es)
SG (1) SG11201810834WA (es)
WO (1) WO2017214395A1 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
KR20190027814A (ko) 2016-06-10 2019-03-15 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CA3040143A1 (en) 2016-10-14 2018-04-19 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
AU2018254577A1 (en) 2017-04-21 2019-12-05 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
MX2020002191A (es) 2017-08-28 2020-10-05 Enanta Pharm Inc Agentes antivirales contra la hepatitis b.
TW201936192A (zh) 2017-12-06 2019-09-16 美商因那塔製藥公司 B 型肝炎抗病毒試劑
WO2019113173A1 (en) * 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CN111566120B (zh) 2017-12-20 2023-09-29 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
WO2019123339A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
PL3759109T3 (pl) * 2018-02-26 2024-03-04 Gilead Sciences, Inc. Podstawione związki pirolizyny jako inhibitory replikacji hbv
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3774883A1 (en) 2018-04-05 2021-02-17 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 ２，２，─環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
JP7296398B2 (ja) 2018-04-06 2023-06-22 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． ３’３’－環状ジヌクレオチド
TW201945388A (zh) 2018-04-12 2019-12-01 美商精密生物科學公司 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶
TW202014193A (zh) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 包含碳環核苷酸之2’3’－環二核苷酸
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
JP2022500466A (ja) 2018-09-21 2022-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としての官能化複素環
MX2021005047A (es) 2018-10-31 2021-09-08 Gilead Sciences Inc Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1.
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
US11198693B2 (en) 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US20220143061A1 (en) 2019-03-07 2022-05-12 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
EP3935065A1 (en) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
DK3934757T3 (da) 2019-03-07 2023-04-17 Inst Of Organic Chemistry And Biochemistry Ascr V V I 2'3'-cykliske dinukleotider og prodrugs deraf
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247561A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) * 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
BR112021026376A2 (pt) 2019-06-25 2022-05-10 Gilead Sciences Inc Proteínas de fusão flt3l-fc e métodos de uso
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021031997A1 (zh) * 2019-08-16 2021-02-25 西藏天晟泰丰药业有限公司 二氢嘧啶衍生物及其用途
WO2021034804A1 (en) 2019-08-19 2021-02-25 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
PE20221111A1 (es) 2019-09-30 2022-07-11 Gilead Sciences Inc Vacunas para vhb y metodos de tratamiento de vhb
WO2021113765A1 (en) 2019-12-06 2021-06-10 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN115605493A (zh) 2020-03-20 2023-01-13 吉利德科学公司（Us） 4′-c-取代的-2-卤代-2′-脱氧腺苷核苷的前药及其制备和使用方法
WO2022031894A1 (en) 2020-08-07 2022-02-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
CN115003673B (zh) * 2020-12-09 2023-08-11 上海维申医药有限公司 一种二氢嘧啶类化合物、其制备方法及应用
KR20240006683A (ko) 2021-05-13 2024-01-15 길리애드 사이언시즈, 인코포레이티드 TLR8 조절 화합물과 항-HBV siRNA 치료제의 조합물
CA3222595A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
US20230046340A1 (en) 2021-06-23 2023-02-16 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3220923A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325353A (en) 1965-06-07 1967-06-13 Monsanto Co Gastropodicidally effective 2', 5-dichloro-4'-cyanosalicylanilides
US3975532A (en) 1973-06-14 1976-08-17 Ici United States Inc. Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain
DE2853220A1 (de) 1978-12-09 1980-07-03 Hoechst Ag Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
US4507481A (en) * 1983-07-29 1985-03-26 Pennwalt Corporation Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
US4917826A (en) 1985-10-18 1990-04-17 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
EP0630644A4 (en) 1992-11-16 1996-02-28 Leonidov Nikolai B ANTIMICROBIAL AND INTERFERON INDUCING PHARMACEUTICAL COMPOUND.
GB9315595D0 (en) 1993-07-28 1993-09-08 Res Inst Medicine Chem New compounds
FR2765577A1 (fr) 1997-07-02 1999-01-08 Hoechst Schering Agrevo Sa Nouveaux amides aromatiques, leur procede de preparation et leur application comme pesticides
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
DE19817262A1 (de) * 1998-04-18 1999-10-21 Bayer Ag Neue 2-heterocyclisch substituierte Dihydropyrimidine
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6498165B1 (en) 1999-06-30 2002-12-24 Merck & Co., Inc. Src kinase inhibitor compounds
DE10012549A1 (de) 2000-03-15 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
EP1505966A4 (en) 2002-05-10 2006-08-30 Bristol Myers Squibb Co 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER
US20040209930A1 (en) 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
US7232825B2 (en) 2003-05-02 2007-06-19 Guoqing P Chen Phenylaminopyrimidine derivatives and methods of use
JP2007505137A (ja) 2003-09-10 2007-03-08 シンタ ファーマシューティカルズ コーポレイション 代謝性障害を処置または予防するためのジヒドロピリジン化合物
WO2005055928A2 (en) 2003-12-02 2005-06-23 The Ohio State University Research Foundation Zn2+ -chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
BRPI0511834A (pt) 2004-07-14 2008-01-08 Ptc Therapeutics Inc métodos por tratar hepatite c
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
KR20080032188A (ko) 2005-07-14 2008-04-14 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
JP5261176B2 (ja) 2005-08-16 2013-08-14 アイカジェン， インコーポレイテッド 電位作動型ナトリウムチャンネル阻害剤
US20070219239A1 (en) 2006-02-10 2007-09-20 Mjalli Adnan M Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
WO2008042639A1 (en) 2006-10-02 2008-04-10 Irm Llc Compounds and compositions as protein kinase inhibitors
US20080120759A1 (en) 2006-11-27 2008-05-29 Tolton Gary A Waterproof cuff assembly for outer wear garment
WO2008120759A1 (ja) 2007-03-30 2008-10-09 Japan Tobacco Inc. ウレア化合物およびその用途
TWI394575B (zh) 2007-07-09 2013-05-01 Golden Biotechnology Corp Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus
CA2693588C (en) 2007-07-13 2015-11-17 Icagen, Inc. Sodium channel inhibitors
WO2009064848A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
ES2527589T3 (es) 2008-04-24 2015-01-27 Msd K.K. Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo
US20110281950A1 (en) 2010-05-11 2011-11-17 Baiocchi Robert A Compositions and methods for reducing proliferation and viability of lymphoblastoid cells
JP5977347B2 (ja) 2011-07-01 2016-08-24 バルーク エス．ブルームバーグ インスティテュート Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
BR112014015197A2 (pt) 2011-12-21 2017-06-13 Novira Therapeutics Inc agentes antivirais de hepatite b
EA026977B1 (ru) * 2012-01-06 2017-06-30 Янссен Сайенсиз Айрлэнд Юси 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b
AU2013226013B2 (en) 2012-02-29 2016-08-11 Baruch S. Blumberg Institute Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation and Their Method of Use
KR20140143160A (ko) 2012-03-31 2014-12-15 에프. 호프만-라 로슈 아게 B형 간염 바이러스 감염의 치료 및 예방을 위한 신규한 4-메틸-다이하이드로피리미딘
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
JP6431478B2 (ja) 2012-06-01 2018-11-28 ドレクセル ユニバーシティ Ｂ型肝炎ウイルスのｃｃｃｄｎａの転写の調節
MX2015002511A (es) 2012-08-24 2016-03-08 Sunshine Lake Pharma Co Ltd Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
CR20210079A (es) 2012-08-28 2021-06-10 Janssen Sciences Ireland Uc Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
WO2014037480A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
EP2912019B1 (en) * 2012-10-25 2021-03-24 Tetra Discovery Partners LLC Heteroaryl inhibitors of pde4
AU2013370300B2 (en) 2012-12-27 2018-11-15 Arbutus Biopharma, Inc. Novel antiviral agents against HBV infection
JP6533217B2 (ja) 2013-05-17 2019-06-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための６−架橋ヘテロアリールジヒドロピリミジン類
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
PL2997019T3 (pl) 2013-05-17 2019-03-29 Janssen Sciences Ireland Uc Pochodne sulfamoilotiofenamidu i ich zastosowanie jako leków do leczenia wirusowego zapalenia wątroby typu B
MX2016006564A (es) 2013-11-19 2017-09-12 Sunshine Lake Pharma Co Ltd Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos.
KR102284938B1 (ko) 2013-11-27 2021-08-02 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP2017504633A (ja) 2014-01-30 2017-02-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染の治療及び予防のための新規なジヒドロキノリジノン
PE20161338A1 (es) 2014-03-07 2016-12-12 Hoffmann La Roche Nuevas heteroarildihidropirimidinas 6-fusionadas para el tratamiento y la profilaxis de la infeccion por virus de la hepatitis b
CN104945395B (zh) 2014-03-28 2018-01-23 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
MX2016014728A (es) 2014-05-13 2017-03-23 Hoffmann La Roche Dihidroquinolizidinonas novedosas para el tratamiento y profilaxis de la infeccion con virus de la hepatitis b.
CN106459061B (zh) 2014-05-30 2020-01-21 齐鲁制药有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
WO2016016370A1 (en) 2014-07-31 2016-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Flt3 receptor antagonists
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
US9550779B2 (en) 2014-12-30 2017-01-24 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
CN107207505B (zh) 2015-02-11 2018-12-14 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的 2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017013046A1 (en) 2015-07-21 2017-01-26 F. Hoffmann-La Roche Ag Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
JP6506880B2 (ja) 2015-07-27 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウィルス感染症の治療および予防のための新規な四環式４−オキソ−ピリジン−３−カルボン酸誘導体
CN107835813B (zh) 2015-07-28 2020-04-24 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的6,7-二氢吡啶并[2,1-a]酞嗪-2-酮类化合物
ES2794639T3 (es) 2015-11-04 2020-11-18 Qilu Pharmaceutical Co Ltd Forma cristalina, método de preparación y compuesto intermedio de compuesto con anillo dihidropirido
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
UY37128A (es) 2016-02-19 2017-09-29 Novartis Ag Compuestos tetracíclicos de piridona como antivirales
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
BR102017010009A2 (pt) 2016-05-27 2017-12-12 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
KR20190027814A (ko) 2016-06-10 2019-03-15 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
WO2017216685A1 (en) 2016-06-16 2017-12-21 Novartis Ag Pentacyclic pyridone compounds as antivirals
WO2017216686A1 (en) 2016-06-16 2017-12-21 Novartis Ag 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals
WO2018019297A1 (zh) 2016-07-29 2018-02-01 银杏树药业(苏州)有限公司 异喹啉酮类化合物及其制备抗病毒药物的应用
JP6991213B2 (ja) 2016-07-29 2022-01-14 グアンジョウ・ルペン・ファーマシューティカル・カンパニー・リミテッド Ｈｂｖ感染の治療のための新規治療薬
TW201811788A (zh) 2016-09-09 2018-04-01 瑞士商諾華公司 作為抗病毒劑之多環吡啶酮化合物
WO2018073753A1 (en) 2016-10-18 2018-04-26 Novartis Ag Fused tetracyclic pyridone compounds as antivirals
US10821103B2 (en) 2016-11-07 2020-11-03 Arbutus Biopharma Corporation Substituted pyridinone-containing trycyclic compounds, and methods using same
CN106810548B (zh) 2017-01-13 2019-02-15 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物
CN106928245B (zh) 2017-03-06 2019-06-11 河南春风医药科技有限公司 一种喹嗪酮类化合物及其制备方法和应用
CN106928215B (zh) 2017-03-06 2019-03-22 河南春风医药科技有限公司 一种喹嗪酮类化合物的制备方法
CN108794481A (zh) 2017-04-28 2018-11-13 齐鲁制药有限公司 化合物的多晶型、其制备方法和用途
WO2019113173A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TW201936192A (zh) 2017-12-06 2019-09-16 美商因那塔製藥公司 B 型肝炎抗病毒試劑

Also Published As

Publication number Publication date
US20200317678A1 (en) 2020-10-08
CL2018003492A1 (es) 2019-04-05
IL263535A (en) 2019-01-31
JP2019521972A (ja) 2019-08-08
US10189846B2 (en) 2019-01-29
SG11201810834WA (en) 2018-12-28
AU2017277664A1 (en) 2019-01-24
US10640511B2 (en) 2020-05-05
US20170355701A1 (en) 2017-12-14
MX2018015315A (es) 2019-04-25
US20190119288A1 (en) 2019-04-25
CA3028228A1 (en) 2017-12-14
EP3468561A1 (en) 2019-04-17
KR20190027814A (ko) 2019-03-15
BR112018075465A2 (pt) 2019-03-19
CN109843296A (zh) 2019-06-04
EP3468561A4 (en) 2019-12-04
WO2017214395A1 (en) 2017-12-14
PH12018550201A1 (en) 2019-04-08

Similar Documents

Publication Publication Date Title
CO2019000069A2 (es) Agentes antivirales contra la hepatitis b
CO2018010748A2 (es) Agentes antivirales contra la hepatitis b
CO2021008055A2 (es) Heterociclos funcionalizados como agentes antivirales
UY37997A (es) Agentes antivirales contra la hepatitis b
UY37998A (es) Agentes antivirales contra la hepatitis b
CO2020002980A2 (es) Agentes antivirales contra la hepatitis b.
UY38059A (es) Heterociclos sustituidos como agentes antivirales
ECSP18069924A (es) Compuestos tetracíclicos de piridona como antivirales
UY38383A (es) Heterociclos funcionalizados como agentes antivirales
DOP2019000201A (es) Compuestos inhibidores del vih
CL2018002549A1 (es) Eliminación del virus de la hepatitis b con agentes antivirales
CO6571891A2 (es) Inhibidores del virus de la hepatitis c.
CL2020001146A1 (es) Nuevas indol-2-carboxamidas sustituidas con pirazolopiperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb).
CU20150096A7 (es) Compuestos de amida y composición farmacéutica para el tratamiento de vih
UY35263A (es) Compuestos terapéuticos
EA201490254A1 (ru) Комбинированное лечение гепатита с
CL2020001145A1 (es) Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb).
CL2021001388A1 (es) Compuestos útiles en la terapia para el vih
CO2019004004A2 (es) Composición farmacéutica y método para el tratamiento de la enfermedad del hígado graso no alcohólico
UY37166A (es) Nucleósidos ánalogos de alquinilo como inhibidores de rinovirus humano
EA201892004A1 (ru) Противовирусные средства для лечения гепатита b
EA201892732A1 (ru) Противовирусные средства для лечения гепатита в
EA202092602A2 (ru) -d-2'-дезокси-2'--фтор-2'--c-замещенные-2-модифицированные-n6-замещенные пуриновые нуклеотиды для лечения вызванных hcv заболеваний