PL3759109T3 - Podstawione związki pirolizyny jako inhibitory replikacji hbv - Google Patents

Podstawione związki pirolizyny jako inhibitory replikacji hbv

Info

Publication number
PL3759109T3
PL3759109T3 PL19710245.2T PL19710245T PL3759109T3 PL 3759109 T3 PL3759109 T3 PL 3759109T3 PL 19710245 T PL19710245 T PL 19710245T PL 3759109 T3 PL3759109 T3 PL 3759109T3
Authority
PL
Poland
Prior art keywords
hbv replication
replication inhibitors
pyrrolizine compounds
substituted
substituted pyrrolizine
Prior art date
Application number
PL19710245.2T
Other languages
English (en)
Inventor
David Alan Gutierrez
Tetsuya Kobayashi
Scott E. Lazerwith
Rick Andrew LEE
Philip Anthony Morganelli
Hyung-Jung Pyun
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of PL3759109T3 publication Critical patent/PL3759109T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
PL19710245.2T 2018-02-26 2019-02-25 Podstawione związki pirolizyny jako inhibitory replikacji hbv PL3759109T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862635262P 2018-02-26 2018-02-26
PCT/US2019/019428 WO2019165374A1 (en) 2018-02-26 2019-02-25 Substituted pyrrolizine compounds as hbv replication inhibitors

Publications (1)

Publication Number Publication Date
PL3759109T3 true PL3759109T3 (pl) 2024-03-04

Family

ID=65724563

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19710245.2T PL3759109T3 (pl) 2018-02-26 2019-02-25 Podstawione związki pirolizyny jako inhibitory replikacji hbv

Country Status (11)

Country Link
US (3) US10836769B2 (pl)
EP (1) EP3759109B1 (pl)
JP (1) JP7050165B2 (pl)
KR (1) KR102526964B1 (pl)
CN (1) CN111788204B (pl)
AU (1) AU2019223182B2 (pl)
CA (1) CA3091142C (pl)
ES (1) ES2962605T3 (pl)
PL (1) PL3759109T3 (pl)
TW (1) TWI731309B (pl)
WO (1) WO2019165374A1 (pl)

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CN115974754A (zh) 2018-03-30 2023-04-18 正大天晴药业集团股份有限公司 含有n杂五元环化合物和用途
CN111247151B (zh) * 2018-05-25 2021-08-10 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
KR20210019489A (ko) * 2018-06-11 2021-02-22 베나토알엑스 파마슈티컬스, 인크. B형 간염 캡시드 조립 조절제
EA202092159A1 (ru) * 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение
CN113365999B (zh) * 2019-01-31 2023-04-14 正大天晴药业集团股份有限公司 含有吡咯并杂环的衣壳蛋白装配抑制剂
CN114430736A (zh) * 2019-09-29 2022-05-03 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂的晶型及其应用
WO2021058001A1 (zh) * 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 N杂五元环化合物的晶型及其应用
WO2021063856A1 (en) * 2019-09-30 2021-04-08 F. Hoffmann-La Roche Ag Substituted 3,4-dihydroquinazoline for the treatment and prophylaxis of hepatitis b virus infection
JP7285027B2 (ja) 2019-11-13 2023-06-01 西安新通薬物研究股▲フン▼有限公司 化合物、その薬学的に許容される塩又は立体異性体、その使用、及び薬物組成物
CN114728973A (zh) * 2019-11-22 2022-07-08 正大天晴药业集团股份有限公司 一种核蛋白抑制剂的晶型及其应用
WO2021119081A1 (en) * 2019-12-10 2021-06-17 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
EP4241770A1 (en) * 2020-11-05 2023-09-13 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pharmaceutical combination containing capsid protein inhibitor and nucleoside analog

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