EA200901157A1 - Конденсированные кольцевые гетероциклические модуляторы киназы - Google Patents

Конденсированные кольцевые гетероциклические модуляторы киназы

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Publication number
EA200901157A1
EA200901157A1 EA200901157A EA200901157A EA200901157A1 EA 200901157 A1 EA200901157 A1 EA 200901157A1 EA 200901157 A EA200901157 A EA 200901157A EA 200901157 A EA200901157 A EA 200901157A EA 200901157 A1 EA200901157 A1 EA 200901157A1
Authority
EA
Eurasian Patent Office
Prior art keywords
condensed ring
ring heterocyclic
modulators
kinase modulators
heterocyclic kinase
Prior art date
Application number
EA200901157A
Other languages
English (en)
Inventor
Чиксу Чен
Брайан Истман
Андреас Госберг
Стефан Н. Градл
Гэвин Херст
Стефани Хопкинс
Кхан Ти Туонг Нгуйен
Ричард Праситто
Пол А. Спренгелер
Роу У. Стинсма
Original Assignee
ЭсДжиИкс ФАРМАСЬЮТИКАЛЗ, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЭсДжиИкс ФАРМАСЬЮТИКАЛЗ, ИНК. filed Critical ЭсДжиИкс ФАРМАСЬЮТИКАЛЗ, ИНК.
Publication of EA200901157A1 publication Critical patent/EA200901157A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

Abstract

В настоящем изобретении предложены конденсированные кольцевые гетероциклы в качестве модуляторов киназы, фармацевтические композиции, содержащие эти модуляторы, и способы применения указанных модуляторов для лечения заболеваний, обусловленных активностью киназы.
EA200901157A 2007-04-10 2008-04-10 Конденсированные кольцевые гетероциклические модуляторы киназы EA200901157A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91106007P 2007-04-10 2007-04-10
PCT/US2008/059962 WO2008124848A1 (en) 2007-04-10 2008-04-10 Fused ring heterocycle kinase modulators

Publications (1)

Publication Number Publication Date
EA200901157A1 true EA200901157A1 (ru) 2010-04-30

Family

ID=39831449

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901157A EA200901157A1 (ru) 2007-04-10 2008-04-10 Конденсированные кольцевые гетероциклические модуляторы киназы

Country Status (12)

Country Link
US (1) US8242280B2 (ru)
EP (1) EP2078020A4 (ru)
JP (1) JP2010524858A (ru)
KR (1) KR20100066419A (ru)
CN (1) CN101679436A (ru)
AU (1) AU2008237019A1 (ru)
BR (1) BRPI0809500A2 (ru)
CA (1) CA2683398A1 (ru)
EA (1) EA200901157A1 (ru)
MX (1) MX2009010984A (ru)
NO (1) NO20093009L (ru)
WO (1) WO2008124848A1 (ru)

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Publication number Publication date
KR20100066419A (ko) 2010-06-17
EP2078020A1 (en) 2009-07-15
WO2008124848A1 (en) 2008-10-16
BRPI0809500A2 (pt) 2014-09-23
MX2009010984A (es) 2010-01-15
EP2078020A4 (en) 2011-10-19
US8242280B2 (en) 2012-08-14
CN101679436A (zh) 2010-03-24
AU2008237019A1 (en) 2008-10-16
NO20093009L (no) 2009-12-17
US20080261921A1 (en) 2008-10-23
JP2010524858A (ja) 2010-07-22
CA2683398A1 (en) 2008-10-16

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