EA201170396A1 - 2-оксо-1,2-дигидрохинолиновые модуляторы иммунной функции - Google Patents
2-оксо-1,2-дигидрохинолиновые модуляторы иммунной функцииInfo
- Publication number
- EA201170396A1 EA201170396A1 EA201170396A EA201170396A EA201170396A1 EA 201170396 A1 EA201170396 A1 EA 201170396A1 EA 201170396 A EA201170396 A EA 201170396A EA 201170396 A EA201170396 A EA 201170396A EA 201170396 A1 EA201170396 A1 EA 201170396A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydroquinoline
- modulators
- oxo
- immune function
- new
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
Настоящее изобретение относится к новым 2-оксо-1,2-дигидрохинолиновым модуляторам иммунной функции, их фармацевтическим композициям и способам их применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9394308P | 2008-09-03 | 2008-09-03 | |
PCT/US2009/055692 WO2010028015A2 (en) | 2008-09-03 | 2009-09-02 | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201170396A1 true EA201170396A1 (ru) | 2011-10-31 |
EA021227B1 EA021227B1 (ru) | 2015-05-29 |
Family
ID=41725771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170396A EA021227B1 (ru) | 2008-09-03 | 2009-09-02 | 2-оксо-1,2-дигидрохинолиновые модуляторы иммунной функции |
Country Status (16)
Country | Link |
---|---|
US (1) | US8252933B2 (ru) |
EP (1) | EP2337779B1 (ru) |
JP (4) | JP2012502038A (ru) |
KR (2) | KR20160079147A (ru) |
CN (2) | CN102143949A (ru) |
AU (1) | AU2009288108B2 (ru) |
BR (1) | BRPI0913518A2 (ru) |
CA (1) | CA2736091A1 (ru) |
EA (1) | EA021227B1 (ru) |
ES (1) | ES2633658T3 (ru) |
IL (1) | IL211341A (ru) |
MX (1) | MX2011002033A (ru) |
NZ (1) | NZ591315A (ru) |
UA (1) | UA104005C2 (ru) |
WO (1) | WO2010028015A2 (ru) |
ZA (1) | ZA201101403B (ru) |
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ME02414B (me) * | 2009-07-30 | 2016-09-20 | Teva Pharma | Tretman kronove bolesti lakvinimodom |
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BR112012022187A2 (pt) * | 2010-03-03 | 2015-09-22 | Teva Pharma | tratamento de artrite reumatóide com a combinação de laquinimod e metotrexato |
KR20130036217A (ko) * | 2010-03-03 | 2013-04-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 관절염의 치료 |
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CN103249306A (zh) | 2010-11-28 | 2013-08-14 | Mapi医药公司 | 中间体化合物以及用于制备喹啉衍生物如拉喹莫德钠的方法 |
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HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
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KR20140054166A (ko) * | 2011-07-28 | 2014-05-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드 및 글라티라머 아세테이트의 병용에 의한 다발성 경화증의 치료 |
KR20140101333A (ko) | 2011-10-12 | 2014-08-19 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드 및 핑골리모드의 조합을 이용한 다발성 경화증의 치료 |
AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
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SG11201404419WA (en) | 2012-02-16 | 2014-10-30 | Teva Pharma | N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof |
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ME02414B (me) | 2009-07-30 | 2016-09-20 | Teva Pharma | Tretman kronove bolesti lakvinimodom |
ES2586843T3 (es) | 2009-08-10 | 2016-10-19 | Teva Pharmaceutical Industries Ltd. | Tratamiento de trastornos relacionados con BDNF usando laquinimod |
KR20130036217A (ko) | 2010-03-03 | 2013-04-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 관절염의 치료 |
WO2011109526A1 (en) | 2010-03-03 | 2011-09-09 | Teva Pharmaceutical Industries Ltd. | Treatment of lupus nephritis using laquinimod |
BR112012022187A2 (pt) | 2010-03-03 | 2015-09-22 | Teva Pharma | tratamento de artrite reumatóide com a combinação de laquinimod e metotrexato |
-
2009
- 2009-09-02 KR KR1020167016924A patent/KR20160079147A/ko not_active Application Discontinuation
- 2009-09-02 WO PCT/US2009/055692 patent/WO2010028015A2/en active Application Filing
- 2009-09-02 CN CN2009801350071A patent/CN102143949A/zh active Pending
- 2009-09-02 EA EA201170396A patent/EA021227B1/ru not_active IP Right Cessation
- 2009-09-02 MX MX2011002033A patent/MX2011002033A/es active IP Right Grant
- 2009-09-02 ES ES09812145.2T patent/ES2633658T3/es active Active
- 2009-09-02 NZ NZ591315A patent/NZ591315A/xx unknown
- 2009-09-02 BR BRPI0913518A patent/BRPI0913518A2/pt active Search and Examination
- 2009-09-02 UA UAA201103798A patent/UA104005C2/ru unknown
- 2009-09-02 JP JP2011526143A patent/JP2012502038A/ja not_active Withdrawn
- 2009-09-02 CN CN201410527963.7A patent/CN104311486A/zh active Pending
- 2009-09-02 EP EP09812145.2A patent/EP2337779B1/en active Active
- 2009-09-02 CA CA2736091A patent/CA2736091A1/en not_active Abandoned
- 2009-09-02 AU AU2009288108A patent/AU2009288108B2/en not_active Ceased
- 2009-09-02 KR KR1020117007125A patent/KR20110048571A/ko not_active Application Discontinuation
- 2009-09-02 US US12/552,663 patent/US8252933B2/en not_active Expired - Fee Related
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2011
- 2011-02-22 IL IL211341A patent/IL211341A/en not_active IP Right Cessation
- 2011-02-22 ZA ZA2011/01403A patent/ZA201101403B/en unknown
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2014
- 2014-07-25 JP JP2014152341A patent/JP2015007060A/ja active Pending
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2016
- 2016-04-11 JP JP2016078660A patent/JP2016183158A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
JP2015007060A (ja) | 2015-01-15 |
JP2016183158A (ja) | 2016-10-20 |
KR20110048571A (ko) | 2011-05-11 |
CA2736091A1 (en) | 2010-03-11 |
EP2337779A2 (en) | 2011-06-29 |
AU2009288108A1 (en) | 2010-03-11 |
MX2011002033A (es) | 2011-05-02 |
JP2012502038A (ja) | 2012-01-26 |
WO2010028015A2 (en) | 2010-03-11 |
CN102143949A (zh) | 2011-08-03 |
US8252933B2 (en) | 2012-08-28 |
NZ591315A (en) | 2012-08-31 |
ES2633658T3 (es) | 2017-09-22 |
US20100055072A1 (en) | 2010-03-04 |
KR20160079147A (ko) | 2016-07-05 |
CN104311486A (zh) | 2015-01-28 |
EA021227B1 (ru) | 2015-05-29 |
ZA201101403B (en) | 2012-05-30 |
EP2337779A4 (en) | 2011-09-14 |
AU2009288108B2 (en) | 2013-10-17 |
WO2010028015A3 (en) | 2010-06-24 |
JP2018048146A (ja) | 2018-03-29 |
UA104005C2 (ru) | 2013-12-25 |
IL211341A (en) | 2013-08-29 |
EP2337779B1 (en) | 2017-04-19 |
BRPI0913518A2 (pt) | 2016-07-26 |
IL211341A0 (en) | 2011-05-31 |
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