JO3041B1 - مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية - Google Patents

مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية

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Publication number
JO3041B1
JO3041B1 JOP/2009/0259A JOP20090259A JO3041B1 JO 3041 B1 JO3041 B1 JO 3041B1 JO P20090259 A JOP20090259 A JO P20090259A JO 3041 B1 JO3041 B1 JO 3041B1
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JO
Jordan
Prior art keywords
diseases
disease
treatment
cartilage
involving
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Application number
JOP/2009/0259A
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English (en)
Inventor
Blanc Javier
Jeanne Marie Menet Christel
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Galapagos Nv
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Publication of JO3041B1 publication Critical patent/JO3041B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

يوضح الاختراع الحالي مركب مبتكر من (1 ،2 ،3) تراي ازولو (1،5، a) بيريدين ويحمل الصيغة التي تتمثل بما يلي : يمكن تحضير هذا المركب على اساس انه مركب دوائي ويمكن ان يستخدم في علاج عدد من الحالات المرضية والوقاية منها لدى الثدييات بما في ذلك الانسان وتشمل على سبيل المثال لا الحصر الامراض المتعلقة بالتاكل الغضروفي و/او العظام على سبيل المثال هشاشة العظام و او الحالات المرتبطة باستجابات المناعة والالتهابات مثل مرض كرون ومرض التهاب المفاصل الروماتيزمي و الصدفية ومرض التهاب المجاري التنفسية التحسية مثل الربو والتهاب الجيوب الانفية، والتهاب المفاصل مجهول السبب والتهاب القولون وامراض التهاب المعدة وحالات امراض الوهن الداخلي( مثل التعقيدات المصاحبة لما بعد العمليات الجراحية او الحالات المتعلقة بالوهن المزمن والمساهمه على سبيل المثال امراض قصور القلب المزمنة) امراض تتعلق بخلل في الغضروف وانتكاسه( مثل امراض متعلقة بتحفيز بناء الخلايا الغضروفية ) والتشوهات الخلفية للغضروف والامراض المتعلقة برفض الزراعه ومستقبل انترلوكين (6) IL6 ( على سبيل المثال رفض زراعة الاعضاء
JOP/2009/0259A 2008-07-25 2009-07-12 مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية JO3041B1 (ar)

Applications Claiming Priority (2)

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US13592008P 2008-07-25 2008-07-25
US22068509P 2009-06-26 2009-06-26

Publications (1)

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JO3041B1 true JO3041B1 (ar) 2016-09-05

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JOP/2009/0259A JO3041B1 (ar) 2008-07-25 2009-07-12 مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية

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US (5) US8853240B2 (ar)
EP (2) EP2361251B1 (ar)
JP (2) JP5559168B2 (ar)
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