DOP2011000022A - Nuevos compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatorias - Google Patents
Nuevos compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatoriasInfo
- Publication number
- DOP2011000022A DOP2011000022A DO2011000022A DO2011000022A DOP2011000022A DO P2011000022 A DOP2011000022 A DO P2011000022A DO 2011000022 A DO2011000022 A DO 2011000022A DO 2011000022 A DO2011000022 A DO 2011000022A DO P2011000022 A DOP2011000022 A DO P2011000022A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- diseases
- conditions
- involve
- treatment
- cartilage
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003412 degenerative effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 206010052779 Transplant rejections Diseases 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 239000002158 endotoxin Substances 0.000 abstract 2
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000028004 allergic respiratory disease Diseases 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000008355 cartilage degradation Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000036244 malformation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 206010039083 rhinitis Diseases 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K31/4965—Non-condensed pyrazines
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- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describe un nuevo compuesto de [1,2,4]Triazolo[1,5- alpiridina que tiene la fórmula representada por la fórmula (I). Este compuesto puede prepararse como un composición farmacéutica, y puede utilizarse para la prevención o tratamiento de una variedad de afecciones en mamíferos incíuyendo humanos, incluyendo a manera de ejemplo no limitante, enfermedades que involucran degradación de cartílago, degradación de hueso y/o articulaciones, por ejemplo osteoartritis; y/o afecciones que involucran inflamación o respuestas inmunitarias, tales como enfermedad de Crohn, artritis reumatoide, psoriasis, enfermedad alérgica de las vías respiratorias, (por ejempio, asma, rinitis), artritis idiopática juvenii, coiitis, enfermedades inflamatorias del intestino, estados de enfermedades concluidos por endotoxina (por ejemplo, complicaciones despues de cirujia de baipas o estados de endotoxina crónicos que contribuyen a, por ejemplo, falla cardiaca crónìca), enfermedades que involucran la disfunción de Ia funcionalidad de los cartilagos (por ejemplo, enfermedades que involucran estimuíación anabóíica de condrocitos), malformaciones de cartílago congénitas, enferrnedades asociadas con Ia hipersecrecion de 1L6 y rechazo al trasplante (por ejemplo, rechazo al trasplante de órgano) y enfermedades proliferativas
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US13592008P | 2008-07-25 | 2008-07-25 | |
US22068509P | 2009-06-26 | 2009-06-26 |
Publications (1)
Publication Number | Publication Date |
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DOP2011000022A true DOP2011000022A (es) | 2011-03-31 |
Family
ID=41021059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DO2011000022A DOP2011000022A (es) | 2008-07-25 | 2011-01-18 | Nuevos compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatorias |
Country Status (36)
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US (5) | US8853240B2 (es) |
EP (2) | EP2346864B1 (es) |
JP (2) | JP5480261B2 (es) |
KR (2) | KR101711911B1 (es) |
CN (2) | CN102105471B (es) |
AR (1) | AR072875A1 (es) |
AU (2) | AU2009273143B2 (es) |
BR (2) | BRPI0916862B8 (es) |
CA (2) | CA2730762C (es) |
CL (1) | CL2009001637A1 (es) |
CO (1) | CO6361925A2 (es) |
CR (1) | CR20110092A (es) |
CY (2) | CY1113945T1 (es) |
DK (2) | DK2346864T3 (es) |
DO (1) | DOP2011000022A (es) |
EA (2) | EA018587B1 (es) |
ES (2) | ES2406691T3 (es) |
HK (2) | HK1158634A1 (es) |
HR (2) | HRP20130357T1 (es) |
IL (2) | IL210262A (es) |
JO (1) | JO3041B1 (es) |
MA (1) | MA32551B1 (es) |
ME (1) | ME02046B (es) |
MX (2) | MX2011000756A (es) |
MY (1) | MY157615A (es) |
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- 2014-07-29 CY CY20141100572T patent/CY1115569T1/el unknown
- 2014-10-06 US US14/507,396 patent/US9415037B2/en active Active
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2016
- 2016-08-15 US US15/236,578 patent/US10206907B2/en active Active
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