BR112015016264A2 - composições de crescimento ósseo termo-sensível - Google Patents

composições de crescimento ósseo termo-sensível

Info

Publication number
BR112015016264A2
BR112015016264A2 BR112015016264A BR112015016264A BR112015016264A2 BR 112015016264 A2 BR112015016264 A2 BR 112015016264A2 BR 112015016264 A BR112015016264 A BR 112015016264A BR 112015016264 A BR112015016264 A BR 112015016264A BR 112015016264 A2 BR112015016264 A2 BR 112015016264A2
Authority
BR
Brazil
Prior art keywords
bone
thermosensitive
injectable
osteogenic
formulation
Prior art date
Application number
BR112015016264A
Other languages
English (en)
Inventor
Shiedlin Aviva
M Mcpherson John
T Sampath Kuber
Philbrook Michael
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of BR112015016264A2 publication Critical patent/BR112015016264A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physics & Mathematics (AREA)

Abstract

resumo patente de invenção: "composições de crescimento ósseo termo-sensível". a presente invenção refere-se à uma composição injetável não invasiva que contém colágeno tipo i, um fator de crescimento osteogênico (osf), tal como, uma proteína morfogenética do osso e um polímero biodegradável termosensível reverse, tal como, poloxâmero 407 em um veículo aquoso. a formulação pode ser administrada não invessamente, por exemplo, por meio de injeção, deste modo, circundando as limitações de muitos produtos de indução óssea atualmente comercializados. a formulação osteogênica injetável efetivamente induz a formação óssea na localidade desejada. esta suspensão injetável pode ser empregada com compostos minerais ósseos bioresorvíveis. (por exemplo, hidroxiapatita, fosfato de tri-cácio) e/ ou glicosaminolicanos (por exemplo, ácido hialurônico, sulfato de heparina) para moldar assim a massa de vidraceiro e/ chapa grossa como implantes substitutos de enxerto de osso para causar nova formação óssea nos procedimentos de fusão da espinha dorsal e cura de fratura.
BR112015016264A 2013-03-14 2014-03-13 composições de crescimento ósseo termo-sensível BR112015016264A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783803P 2013-03-14 2013-03-14
PCT/US2014/025355 WO2014159863A1 (en) 2013-03-14 2014-03-13 Thermo-sensitive bone growth compositions

Publications (1)

Publication Number Publication Date
BR112015016264A2 true BR112015016264A2 (pt) 2017-07-11

Family

ID=51527876

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015016264A BR112015016264A2 (pt) 2013-03-14 2014-03-13 composições de crescimento ósseo termo-sensível

Country Status (14)

Country Link
US (2) US20140271471A1 (pt)
EP (1) EP2970421A4 (pt)
JP (1) JP2016514030A (pt)
KR (1) KR20150129717A (pt)
CN (1) CN105209484A (pt)
AU (1) AU2014244369A1 (pt)
BR (1) BR112015016264A2 (pt)
CA (1) CA2905455A1 (pt)
HK (1) HK1220216A1 (pt)
IL (1) IL241402A0 (pt)
MX (1) MX2015011820A (pt)
RU (1) RU2015144004A (pt)
SG (1) SG11201507280TA (pt)
WO (1) WO2014159863A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105496943B (zh) * 2015-12-16 2018-11-27 白艳洁 纳米羟基磷灰石-PGE2-PLGA-MSs杂化在位凝胶及其制备方法
EP3381479A1 (de) * 2017-03-29 2018-10-03 ARTOSS GmbH Trägerzusammensetzung für knochenersatzmaterialien
WO2019099860A2 (en) * 2017-11-17 2019-05-23 Medline Industries, Inc. Wound treatment containing collagen and a gelatin-reducing agent, and method for promoting wound healing
TN2018000307A1 (fr) * 2018-09-03 2020-01-16 Ghidhaoui Abir Injection osseuse & cartilagineuse à base de kératine béta.
IT201900013311A1 (it) 2019-07-30 2021-01-30 Tecnoss S R L Nuova composizione riempitiva tissutale
CN113908341A (zh) * 2021-10-26 2022-01-11 深圳市迈捷生命科学有限公司 一种可注射型骨诱导修复材料及其制备方法
WO2024184800A1 (en) * 2023-03-07 2024-09-12 Delim Cosmetics & Pharma S.r.l. Mucoadhesive thermoreversible compositions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674500B2 (en) * 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3604710B2 (ja) * 1993-10-08 2004-12-22 マルハ株式会社 骨粗鬆症予防及び治療剤
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US6281195B1 (en) * 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7572440B2 (en) * 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
ATE253385T1 (de) * 1999-02-04 2003-11-15 Sdgi Holdings Inc Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US20020176893A1 (en) * 2001-02-02 2002-11-28 Wironen John F. Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue
JP2003055238A (ja) * 2001-08-09 2003-02-26 Katsumichi Matsushige 抗骨粗鬆活性を有する組成物
WO2003043576A2 (en) * 2001-11-20 2003-05-30 Depuy Products, Inc. Flowable osteogenic and chondrogenic compositions
US20040091462A1 (en) * 2002-08-20 2004-05-13 Lin Steve T. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
ITPD20030286A1 (it) * 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US7951880B2 (en) * 2004-12-10 2011-05-31 University Of Iowa Research Foundation Compositions for breast implant filling and methods of use
US7427293B2 (en) * 2006-03-28 2008-09-23 Sdgi Holdings, Inc. Osteochondral plug graft, kit and method
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US20080058954A1 (en) * 2006-08-22 2008-03-06 Hai Trieu Methods of treating spinal injuries using injectable flowable compositions comprising organic materials
US20120071437A1 (en) * 2007-07-30 2012-03-22 Allergan, Inc. Tunable crosslinked polysaccharide compositions
RU2504360C2 (ru) * 2008-08-12 2014-01-20 Новартис Аг Фармацевтические композиции
KR101001855B1 (ko) * 2008-10-22 2010-12-17 한국과학기술연구원 생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 플루로닉 유도체 하이드로겔 및 이의 제조방법
JP5885206B2 (ja) * 2010-09-15 2016-03-15 江崎グリコ株式会社 グリコーゲンを含有する骨形成促進剤
AU2012243410B8 (en) * 2011-04-11 2016-11-17 Red Rock Regeneration Inc. System and method for multiphasic release of growth factors

Also Published As

Publication number Publication date
AU2014244369A1 (en) 2015-11-05
US20180104180A1 (en) 2018-04-19
US20140271471A1 (en) 2014-09-18
KR20150129717A (ko) 2015-11-20
SG11201507280TA (en) 2015-10-29
RU2015144004A (ru) 2017-04-19
WO2014159863A1 (en) 2014-10-02
EP2970421A4 (en) 2016-11-02
JP2016514030A (ja) 2016-05-19
MX2015011820A (es) 2016-01-25
IL241402A0 (en) 2015-11-30
CN105209484A (zh) 2015-12-30
CA2905455A1 (en) 2014-10-02
HK1220216A1 (zh) 2017-04-28
EP2970421A1 (en) 2016-01-20

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements